HIV infection in humans is considered pandemic by the World Health Organization (WHO). Nevertheless, complacency about HIV may play a key role in HIV risk. From its discovery in 1981 to 2006, AIDS killed more than 25 million people. HIV infects about 0.6% of the world's population. In 2005, AIDS claimed an estimated 2.4–3.3 million lives, of which more than 570,000 were children. A third of these deaths occurred in Sub-Saharan Africa, retarding economic growth and increasing poverty. At that time, it was estimated that HIV would infect 90 million people in Africa, resulting in a minimum estimate of 18 million orphans. Antiretroviral treatment reduces both the mortality and the morbidity of HIV infection, but routine access to antiretroviral medication is not available in all countries.
HIV infects primarily vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: First, direct viral killing of infected cells; second, increased rates of apoptosis in infected cells; and third, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.
Most untreated people infected with HIV-1 eventually develop AIDS. These individuals mostly die from opportunistic infections or malignancies associated with the progressive failure of the immune system. HIV progresses to AIDS at a variable rate affected by viral, host, and environmental factors; most will progress to AIDS within 10 years of HIV infection: some will have progressed much sooner, and some will take much longer. Treatment with anti-retrovirals increases the life expectancy of people infected with HIV. Even after HIV has progressed to diagnosable AIDS, the average survival time with antiretroviral therapy was estimated to be more than 5 years as of 2005. Without antiretroviral therapy, someone who has AIDS typically dies within a year.
The glossary app includes the following features:
• Toggle button to switch between English and Spanish terms and definitions
• Audio feature to hear correct pronunciation of terms in English and Spanish
• "Random" button that signals the app to display a randomly selected term and definition
AIDSinfo, a service of the U.S. Department of Health and Human Services (HHS), offers health care providers and consumers access to the latest, federally approved HIV/AIDS medical practice guidelines, HIV treatment and prevention clinical trials, and other HIV-related research information. AIDSinfo is collectively sponsored by the Office of AIDS Research (OAR), the National Institute of Allergy and Infectious Diseases (NIAID), and the National Library of Medicine (NLM)—three entities within the National Institutes of Health (NIH); the Health Resources and Services Administration (HRSA); and the Centers for Disease Control and Prevention (CDC).
- Browse Knowledge Base of HIV/AIDS related topics
- Ask our experts your HIV/AIDS-related questions
- View promotional videos
- View photo albums from recent events
- Get up-to-the-minute notifications of HIV/AIDS related news & events
- Find HIV/AIDS testing centres in your area
The program provides continuing professional development certificate programs, practice guidelines, and drug reference information, as well as referral clinical support. inPractice® Africa is also available as downloadable apps for tablets, smartphones, and Windows PCs.
How It Works
inPractice® Africa content can be accessed in 2 ways:
• Easy-to-search point-of-care reference information as you treat your patients
• Review complete modules and earn credit
Accredited curricula offered through inPractice® Africa consist of learning modules to complete in any order, and when all are successfully completed you receive your program certificate. CPD credit is also offered for each learning module.
Applying South Africa National Guidelines on Antiretroviral Therapy
Comprehensive 10-chapter curriculum on the use of antiretroviral therapy in South Africa:
• Identify and prepare patients for treatment, recommended regimens, monitoring treatment, managing adverse effects, treatment failure, and considerations in specific populations including women, children, and patients with advanced disease.
Management of Tuberculosis in HIV-Coinfected Patients
5 chapters detailing:
• The prevention, diagnosis, and treatment of drug-sensitive and drug-resistant tuberculosis in HIV-infected patients in South Africa.
Nursing Care of HIV-Infected Patients
A 10-chapter comprehensive curriculum designed to:
• Provide nurses and nurse managers with guidance on diverse aspects of HIV care, including models of service delivery, management of antiretroviral therapy, and on-treatment considerations such as adverse events, adherence, and care of specific populations including women, children, and tuberculosis-coinfected patients.
inPractice® Africa offers South Africa–specific resources available through search, keyword, or by index that include.
• Drug Database
• Clinical Support (hotline for further clinical questions and support)
This program was developed in cooperation with two leading South African organizations involved in HIV/AIDS medical education: the Foundation for Professional Development and the University of the Witwatersrand.
inPractice® Africa is made possible by a public–private partnership grant from US Agency for International Development (USAID) and grants from Abbott, Gilead Sciences, Janssen, and Merck pharmaceutical companies.
This Manual is the third edition involving the contribution of 32 reviewer-authors drawn from The Chinese University of Hong Kong, The University of Hong Kong, Department of Health Integrated Treatment Centre, Social Hygiene Service and Tuberculosis and Chest Service, as well as three HIV services under Hospital Authority – Queen Elizabeth Hospital, Princess Margaret Hospital, and Prince of Wales Hospital.
- Chapters are grouped under 6 sections – basics of HIV medicine, public health management, clinical management, opportunistic and concurrent infections, neoplasia, Special settings & the community.
- Algorithms continue to be a key component in many chapters.
- References are linked to the sources.
- Link to interactive tool giving useful information of each registered antiretroviral compound, from its basic characteristics, formulation, dosage to side effects and cautions for prescribing doctors.
- All important local guidelines on HIV management are appendiced. This is important for frontline professionals as a one-stop resource when it comes to HIV management.
- An HIV/AIDS Report form can be downloaded.
- Local perspective to HIV management.
- Also useful to students in medicine, nursing, public health and other health care subjects.
Editor and Project Coordinator
Shui Shan LEE
Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong
Anti-HIV Med is developed by the HIV Research Team at Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong as an independent tool. This is also currently accessible as a supplement appended to HIV Manual 3rd Edition.
This application has been developed for exclusive use by health professionals. If you are not biomedical personnel you should not download this application.
Management of HIV and viral hepatitis infections are ever-changing fields and
resistance to antiviral agents represents one major issue for the management of infected
This application provides instant and easy access to regularly updated information about
specific HIV, HCV and HBV mutations related to resistance to antiviral drugs. Both
in vitro and in vivo information is provided for each specific drug resistance mutation
selected by users.
This is an “offline” application that is downloaded to your device. An internet
connection is not required to use the application.
The application has been developed by Lluita contra la Sida Foundation through support
from MSD, Gilead and BMS.
Payment will be charged to your Google Play Account at confirmation of purchase. Subscriptions automatically renew unless auto-renew is turned off at least 24-hours before the end of the current subscription period. Your Google Play Account will be charged for renewal within 24-hours prior to the end of the current subscription period. The cost of renewal will be the same as the initial subscription cost. Subscriptions may be managed by the user and auto-renewal may be turned off by going to the Google Play Store app and searching for the Sanford Guide app detail page. No cancellation of a current subscription is allowed during the active subscription period.
Subscriptions include monthly updates. With this App, your Sanford Guide will never be out-of date. You decide when to subscribe and your subscription runs for 12 months from the date of purchase.
The Sanford Guide to Antimicrobial Therapy is the leading reference for health care professionals engaged in the treatment of infectious diseases. Subscribe for access to comprehensive, treatment-focused coverage of bacterial, fungal, mycobacterial, parasitic, viral infections, and HIV/AIDS; anti-infective drug information, prevention and useful tables and tools, including activity spectra for antibacterial, antifungal and antiviral agents, and calculators to assist with dosing.
The Sanford Guide to HIV/AIDS Therapy has provided health care professionals with up-to-date recommendations for diagnosis and treatment of HIV disease, AIDS, and AIDS-related complications since 1992.
The Sanford Guide to Hepatitis Diagnosis and Treatment provides comprehensive coverage of Hepatitis A, B and C infections.
The Sanford Guides are edited by leading experts from foremost academic centers. Monthly content updates include new literature references and updated recommendations based on recently published reports and feedback from users.
For HIV In Children, registration is required on www.hivinchildren.org to log in and use this tool.
*Data services are required to access all sections of the application.
*Supports API levels 8 & above (Android 2.2 and above)
TAGS: hiv, children, hiv in children, grand rounds, ask doctor, pediatriconcall
inPractice provides insight and practical recommendations for HIV patient care.
Subject Matter: HIV
Physicians and other healthcare professionals including:
• Infectious disease specialists
• Primary care practitioners managing patients with HIV
• Other specialists managing patients with HIV
• Nurses, nurse practitioners, and physician assistants caring for patients with HIV
• Expert-authored, comprehensive HIV reference work
• Continuously updated to incorporate latest findings and best practices
• Complete drug database (by Lexi-Comp; includes all FDA-approved drugs)
• Practice guidelines
• Relevant PubMed abstracts (MEDLINE)
In Practice—Not Just in Theory
Translates the constant stream of latest developments in HIV into clinically applicable information.
• Search and find targeted recommendations for your patient care questions
• Know that the evidence supports your decisions
Integrates insightful Conference Coverage, drug developments, journal citations, and guidelines to keep you abreast of the developments you can apply to practice.
Education With Relevance
Earn CME credit for the topics you’re searching anyway. (To claim credit, just visit the free, companion Web site.)
• Easily share information with colleagues or trainees
• Integrated bookmark function for quick return access to key topics
• Companion Web site included
How to Gain Access:
Free, one-time registration or use your existing Clinical Care Options member ID. (Your information will not be shared or sold to third parties.)