So explore the human body like never before! With hundreds of interactive anatomy information and descriptions of thousands of objects in the body, this app will help you discover what you want to know about human anatomy.
Axis 1: pharmacological target and mode of action – Brings state of the art knowledge on targeted neurotransmitter / molecule / system being modified + relevant mode / mechanism of action
Axis 2: approved indications – Is based on the recommendations of major regulatory bodies (e.g. FDA, EMA, etc.)
Axis 3: efficacy and side effects – Together with the “practical notes”, summarizes the "collective clinical wisdom" of the committee
Axis 4: neurobiology – Is derived from empirical data
NbN, which currently encompasses 108 compounds, includes all the widely used psychotropic.
1. Medication Included.
In principle, medication with approved CNS indications are included. In this app you will find the medications that we were aware of. The taskforce welcome proposals to include medications that for one reason or another were omitted. (Please check our website, www.ecnp.eu/nomenclature).
1a. Fixed combination of medication.
The taskforce decided not to include them. This decision reflects the critical view of the taskforce on this type of practice.
2. Inclusion criteria for the efficacy section.
Positive single, large, RCT and/or "heavy solid weight" clinical data.
3. Inclusion criteria for the side effects section.
Only prevalent or life-threatening side effects were included.
4. The committee note (Practical Note)
Presented in a nutshellclinical knowledge that has been "filtered" through the taskforce clinical "sieve".
This axis is focused on the biology. It is divided into preclinical and clinical sections, with the emphasis on the latter.
Included only were it is clinically relevant and if human data is available. Please note that it is incomplete in this edition but we intend to complete it for the next edition.
7. Uptake Inhibitors.
Figures for the SERT/NET or NET/SERT uptake inhibition have been taken from studies of uptake inhibition which use human transporters. If there is more than one study we have taken a mean. If there are only rat transporter studies, we have used these in the same way but added (rat) to the description.
This app has been developed by the taskforce of 5 well respected international organizations:
ECNP - European College of Neuropsychopharmacology
ACNP - American College of Neuropsychopharmacology
AsCNP - Asian College of Neuropsychopharmacology
CINP - International College of Neuropsychopharmacology
IUPHAR - International Union of Basic and Clinical Pharmacology
The taskforce did its best to ensure a balanced, cutting edge, scientific based document. Although the product that you see is the result of 6 years work, we do realize that it is not perfect and that there are mistakes and significant omissions. We rely on you to help us to improve this imperfect, this beta 1 version (draft if you wish) of this app. Integral part of the NbN and a key for its development and success is the feedback element. The taskforce has put forward a Wikipedia kind of approach (emphasizing the importance and strength of the clinicians / pharmacologist's "collective wisdom") as one of the corner stones. Accordingly, we will more than welcome any feedback and promise to take it into account while preparing the 2015 edition.
* Please drop me an email if you see bugs or if you have ideas for specific extensions. *
This completely free app offers a set of various dedicated tools grouped in four sections helping scientists and students:
--Solutions (Solutions & Buffers)--
This section covers general applications in chemistry and biochemistry laboratories like making of solutions with defined molarity and diluting a stock solution to a working solution. It also facilitates the selection of buffer substances for given a pH.
--Proteins (Proteins, Peptides & Amino Acids)--
This set of tools covers the work with amino acids, peptides and Proteins. It allows looking up structures and properties of all amino acids as well as user defined peptides. It also calculates the different fragment masses of specific peptides subjected to mass spectrometry. As chemicals like small molecules or peptides can be modified or may undergo fragment loss in mass spectrometry, one of the available tools tries to identify these mass shifts. A last tool facilitates the accession of protein information from Uniprot (internet connection needed).
The peptide synthesis section provides various information on solid phase peptide synthesis (SPPS). Coupling methods and resin loading protocols as well as their concomitant colorimetric tests are explained. Additionally, resin cleavage and deprotection strategies are given. A detailed list of coupling reagent properties completes the section.
--Chemicals (Chemicals & Elements)--
This extract of utilities covers the work with chemicals, metabolites and elements. It allows the calculation of molecular weight using chemical formulas or built-in substances. Chemical formulas from masses measured in mass spectrometry can be found which are linked to representative metabolites (small molecules). One tool allows the lookup of detergent properties sorted and filtered by different characteristics. A last tool lists all elements of the periodic table of elements with detailed and relevant information about them.
The four main menu sections MAIN, TREND, SETTINGS and ALARM provide easy navigation and control of the process.
- Overview of all system critical parameters.
- Access to controllers of single system parameters. Measurement and control capabilities feature temperature, stirrer speed, pH, DO, gas flow control, foam control, level control as well as possibilities for substrate addition and control for fed batch processes. PID settings may be adjusted by the user as well.
- Access to calibration of probes.
- Overview on process parameter course.
- Up to six process parameters may be displayed at the same time.
- All parameters are displayed in a different colour for easy overview and navigation.
- User management: Multiple users with individual password
- Data logger
- Culture vessel selection with automatic parameter adjustment
- Network settings
- For process parameters
- For setpoint overshoots
- Listing of all occurred alarms