論文 1. Uemura O, Nagai T, Ishikura K, et al: Creatinine-based equation to estimate the glomerular filtration rate in Japanese children and adolescents with chronic kidney disease. Clin Exp Nephrol. 2013 Sep 7. [Epub ahead of print] 2. Uemura O, Nagai T, Ishikura K, et al: Cystatin C-based equation to estimate glomerular filtration rate in Japanese children and adolescents. Clin Exp Nephrol. 2013 Nov 20. [Epub ahead of print]
Inulin clearance is the gold standard glomerular filtration rate (GFR) calculated, inspection procedure is complicated, especially in children. So far, we've used the (eGFR) GFR estimating equation in order to evaluate the renal function in children easily in daily practice. However, the former Schwartz estimating equation, which is a general-purpose so far, there is a problem that the Jaffé method rather than the enzymatic method in which serum creatinine (s-Cr) measurements have been used in Japan now, new Schwartz estimating equation in the enzyme method It was amended, but there was a problem of using a common factor in the 1-year-old to 16-year-old, including puberty to increase rapidly in muscle mass. There is also a difference in muscle mass and renal function by race. Therefore, we made a eGFR creation of two Japanese-specific.
EGFR of using the s-Cr I. The Japanese children For 2 years to 18 years, divided into men and women, determine serum creatinine reference value (ref Cr) from height as described below. I have shown below the article. When Ht (m) and the height for the boys, ref Cr =-1.259Ht5 +7.815 Ht4-18.57Ht3 +21.39 Ht2-11.71Ht +2.628 When Ht (m) and the height for girls, ref Cr =-4.536Ht5 +27.16 Ht4-63.47Ht3 +72.43 Ht2-40.06Ht +8.778 Did on the calculation, eGFR (ml/min/1.73m2) = 110.2 × (ref Cr / s-Cr) +2.93 EGFR will be 5101. Unfortunately, you will not be able to use the eGFR of using the s-Cr in 2 years.
EGFR of using the cysC of II. Japanese children I have created a eGFR using cysC. EGFR will be calculated by the following formula for one month to 18 years. I have shown below the article. eGFR (mL/min/1.73 m2) = 104.1 × 1/serum cysC (mg / L) - 7.80
In addition, in order to know whether the abnormal GFR that is required whether the normal reference value of GFR is required. You have created a GFR reference value table by putting in estimating equation of the data when you create a reference value of cysC and s-Cr of Japanese children previously. 18 years and under 2 years of age or older in the eGFR using the s-Cr, and as it was calculated in eGFR of using the cysC 2 years 3 months or more, there is no reference value of less than three months. Alert of yellow character has become so out of alert deficit, if less than 75% if less than 50% of normal renal function. I think this application is utilized, pediatric CKD patients is early detection and early treatment, and if Tsunagare happiness of his sons.
Paper . 1 Uemura O, Nagai T, Ishikura K, et al:... Creatinine-based equation to estimate the glomerular filtration rate in Japanese children and adolescents with chronic kidney disease Clin Exp Nephrol 2013 Sep 7 [Epub ahead of print] . 2 Uemura O, Nagai T, Ishikura K, et al:... Cystatin C-based equation to estimate glomerular filtration rate in Japanese children and adolescents Clin Exp Nephrol 2013 Nov 20 [Epub ahead of print]