While there are a number of texts dedicated to individual aspectsof pharmaceutical research and development, this unique contributedwork takes a holistic and integrative approach to the use ofcomputers in all phases of drug discovery, development, andmarketing. It explains how applications are used at various stages,including bioinformatics, data mining, predicting human response todrugs, and high-throughput screening. By providing a comprehensiveview, the book offers readers a unique framework and systemsperspective from which they can devise strategies to thoroughlyexploit the use of computers in their organizations during allphases of the discovery and development process.
Chapters are organized into the following sections:
* Computers in pharmaceutical research and development: a generaloverview
* Understanding diseases: mining complex systems forknowledge
* Scientific information handling and enhancing productivity
* Computers in drug discovery
* Computers in preclinical development
* Computers in development decision making, economics, and marketanalysis
* Computers in clinical development
* Future applications and future development
Each chapter is written by one or more leading experts in the fieldand carefully edited to ensure a consistent structure and approachthroughout the book. Figures are used extensively to illustratecomplex concepts and multifaceted processes. References areprovided in each chapter to enable readers to continueinvestigating a particular topic in depth. Finally, tables ofsoftware resources are provided in many of the chapters.
This is essential reading for IT professionals and scientists inthe pharmaceutical industry as well as researchers involved ininformatics and ADMET, drug discovery, and technology development.The book's cross-functional, all-phases approach provides a uniqueopportunity for a holistic analysis and assessment of computerapplications in pharmaceutics.
It is believed that selecting the "right" drug candidate fordevelopment is the key to success. In the last decade,pharmaceutical R&D departments have integrated pharmacokineticsand drug metabolism, pharmaceutics, and toxicology into early drugdiscovery to improve the assessment of potential drug compounds.Now, Evaluation of Drug Candidates for Preclinical Developmentprovides a complete view and understanding of whyabsorption-distribution-metabolism-excretion-toxicology (ADMET)plays a pivotal role in drug discovery and development.
Encompassing the three major interrelated areas in whichoptimization and evaluation of drug developability is mostcritical—pharmacokinetics and drug metabolism, pharmaceutics,and safety assessment—this unique resource encouragesintegrated thinking in drug discovery. The contributors to thisvolume:
Cover drug transporters, cytochrome P-450 and drug-druginteractions, plasma protein binding, stability, drug formulation,preclinical safety assessment, toxicology, and toxicokinetics
Address developability issues that challenge pharma companies,moving beyond isolated experimental results
Reveal connections between the key scientific areas that arecritical for successful drug discovery and development
Inspire forward-thinking strategies and decision-makingprocesses in preclinical evaluation to maximize the potential ofdrug candidates to progress through development efficiently andmeet the increasing demands of the marketplace
Evaluation of Drug Candidates for Preclinical Development servesas an introductory reference for those new to the pharmaceuticalindustry and drug discovery in particular. It is especially wellsuited for scientists and management teams in small- to mid-sizedpharmaceutical companies, as well as academic researchers andgraduate students concerned with the practical aspects related tothe evaluation of drug developability.
Providing a comprehensive overview of chemosensors—organicmolecules designed to bind and sense small molecules or metalions—and their applications, Chemosensors: Principles,Strategies, and Applications is an accessible one-stop resource foranalysts, clinicians, and graduate students studying advancedchemistry and chemosensing.
Chemosensors function on a molecular level, generating a signalupon binding. The book reviews their synthesis, design, andapplications for detecting biological and organic molecules as wellas metal ions. The text highlights applications in drug discoveryand catalyses that have not been well covered elsewhere.
Covering such topics as molecular recognition, detectionmethods, design strategies, and important biological issues, thebook is broken into four sections that examine intermolecularinteractions, strategies in sensor design, detection methods, andcase studies in metal, saccharide, and amino acid sensing.
An indispensable source of information for chemical andbiomedical experts using sensors, Chemosensors includes casestudies to make the material both accessible and understandable tochemists of all backgrounds.
• Helps readers understand progress in drug delivery research and applications
• Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics
• Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics
• Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery
The second most abundant transition element in living organisms,zinc spans all areas of metabolism, with zinc-containing proteinsoffering both established and potential drug targets. DrugDesign of Zinc-Enzyme Inhibitors brings together functional andstructural information relevant to these zinc-containing targets.With up-to-date overviews of the latest developments field, thisunique and comprehensive text enables readers to understand zincenzymes and evaluate them in a drug design context.
With contributions from the leaders of today's research, DrugDesign of Zinc-Enzyme Inhibitors covers such key topics as:
Major drug targets like carbonic anhydrases, matrixmetalloproteinases, bacterial proteases, angiotensin-convertingenzyme, histone deacetylase, and APOBEC3G
Roles of recently discovered zinc-containing isozymes in cancer,obesity, epilepsy, pain management, malaria, and otherconditions
Cross reactivity of zinc-enzyme inhibitors and activators
The extensive use of X-ray crystallography and QSAR studies forunderstanding zinc-containing proteins
An essential resource for the discovery and development of newdrug molecules, Drug Design of Zinc-Enzyme Inhibitors givesresearchers, professionals, students, and academics the foundationto understand and work with zinc enzyme inhibitors andactivators.
• Describes drug transporter families, mechanisms,and clinical implications along with experimental methods forstudying and characterizing drug transporters
• Includes new chapters on multidrug and toxin extrusionproteins, placental transport and in silico approaches in drugdiscovery
• Has a new chapter covering regulatory guidance for theevaluation of drug transport in drug development with globalcriteria used for drug transporters in clinical trials
• Arranges material to go from fundamental mechanisms toclinical outcomes, making the book useful for novice and expertreaders