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The study of stem cell biology is under intensive investigations. Because stem cells have the unique capability to self-renew and differentiate into one or several cell types, they play a critical role in development, tissue homeostasis and regeneration. Stem cells also constitute promising cell candidates for cell therapy.

 

The aim of this book is to provide an accurate knowledge on stem cell biology and regenerative medicine. This book will cover many topics in the field and is based on seminars given by recognized scientists involved the international master program on stem cell biology at the University Pierre and Marie Curie (UPMC) in Paris.

Content

 

Preface. Pierre Charbord and Charles Durand.

 

1) General concepts 

 

1.Stem cell concepts. Charles Durand and Pierre Charbord.

2.Transcriptional regulation in stem cells. Eric Soler and Frank Grosveld.

3.DNA repair in stem cells. Leyla Vahidi Ferdousi and Miria Ricchetti.

4. Stem cells and epigenetic regulation. Emma L. Walton and Claire Francastel.

5. Hydra and the evolution of stem cells. Alexander Klimovich, Anna Marei Böhm and Thomas C.G. Bosch.

6. Ontogeny of stem cells. Thierry Jaffredo.

7. Regeneration in anamniotic vertebrates. Dunja Knapp.

8. Computational models of spatio-temporal stem cell organization. Peter Buske and Joerg Galle.

 

 

2) Pluripotent stem cells 

 

9. X chromosome inactivation in stem cells and development. Agnese Loda, Friedemann Loos and Joost Gribnau.

10. Molecular machinery of reprogramming. Romain Desprat, Ollivier Milhavet and Jean-Marc Lemaitre.

11. Modeling human genetic disorders using induced pluripotent stem cells. Franck Lebrin.

 

 

3) Adult stem cells 

 

12. Developmental biology of hematopoietic stem cells : Cellular aspects. Laurent Yvernogeau, Jean-Charles Boisset and Catherine Robin.

13. Developmental biology of haematopoietic stem cells: Cell intrinsic and extrinsic regulators of their emergence. Katrin Ottersbach.

14. Biology of hematopoietic stem cells in the adult. Marie-Laure Arcangeli, Rima Haddad, Francoise Pflumio.

15. Epithelial stem cells in the skin. Romain Fontaine, Mathieu Castela and Selim Aractingi.

16. Skeletal muscle stem cells. Elisa Negroni, Maximilien Bencze, Stéphanie Duguez, Gillian Butler-Browne and Vincent Mouly.

17. Mammary stem cells. Marie-Ange Deugnier, Marisa M. Faraldo and Marina A. Glukhova.

18. Intestinal stem cells. Silvia Fre.

19. Neural stem cells. Nathalie Kubis and Martin Catala.

20. Dental stem cells. Anne Poliard.

21. Bone marrow Mesenchymal Stem Cells: from stemness to stromal property of hematopoietic support. Pierre Charbord and Bruno Delorme.

22. Retinal stem cells. Olivier Goureau, Angélique Terray, Katherine S. Matho, Sacha Reichman, and Gael Orieux.

 

 

4) Stem cell-related diseases and therapy using stem cells

 

23. Leukemic stem cells: what the concept brings to disease and patient management. Berent Lunden and Christine Chomienne.

24. Stem cells for cardiac repair. Philippe Menasché.

25. Stem cells for red blood cell production. Christelle Mazurier, Guillaume F Rousseau, Luc Douay and Hélène Lapillonne.

26. Prospectives for therapy with stem cells in skeletal muscular diseases. Maximilien Bencze, Elisa Negroni, Vincent Mouly and Gillian Butler-Browne.

 

 

5) Regulatory and philosophical aspects

 

27. Legal framework for research on Human Embryonic Stem Cells in France and in Europe. Arnaud de Guerra, Emmanuelle Prada-Bordenave

28. Stem cell epistemological issues. Lucie Laplane.

29. Future outlook. Pierre Charbord and Charles Durand.

 

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