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A tiny scrap of genetic information determines our sex; it also consigns many of us to a life of disease, directs or disrupts the everyday working of our bodies, and forces women to live as genetic chimeras. The culprit--so necessary and yet the source of such upheaval--is the X chromosome, and this is its story. An enlightening and entertaining tour of the cultural and natural history of this intriguing member of the genome, The X in Sex traces the journey toward our current understanding of the nature of X. From its chance discovery in the nineteenth century to the promise and implications of ongoing research, David Bainbridge shows how the X evolved and where it and its counterpart Y are going, how it helps assign developing human babies their sex--and maybe even their sexuality--and how it affects our lives in infinitely complex and subtle ways. X offers cures for disease, challenges our cultural, ethical, and scientific assumptions about maleness and femaleness, and has even reshaped our views of human evolution and human nature.



Table of Contents:

Prologue

1. Making a Difference
Interlude: What Is It, Exactly?
2. The Duke of Kent's Testicles
Interlude: How Sexy Is X?
3. The Double Life of Women

Epilogue: The Chosen One

Further Reading
Glossary
Index



Reviews of this book:
The author of Making Babies takes a lively, witty tour of the X chromosome, creator of "a delicious symmetry between men and women"...Entertaining and informative...A fine demonstration of science made accessible.
--Kirkus Reviews

Reviews of this book:
A well-written, well-researched, easy-to-read study that explains what has been learned about the X and Y chromosomes using DNA sequencing and other molecular biology techniques. British biologist Bainbridge...has pulled together historical and current scientific research about how the X and Y chromosomes affect us and what the genes on these chromosomes actually do, like causing sex-linked diseases and color blindness...An excellent example of good science writing...Recommended.
--Margaret Henderson, Library Journal

Reviews of this book:
Bainbridge is an essentialist, interested in understanding what aspects of gender are biologically driven, and why...He has a central question he wants to answer. The question is not so much why men and women are different (a worn topic that's the subject of too many Mars-and-Venus bestsellers) but, far more specific and far more interesting: Why are men and women more different than they need to be?
--Liza Mundy, Washington Post

Reviews of this book:
Bainbridge summarizes our knowledge of the genetic information that determines one's sex by recounting the ancients' speculations about the genesis of gender, following with modern biologists' discovery of the X and Y chromosomes about a century ago, and of the sex-determining gene Sry in the 1990s. In a discussion rich with history, evolution, and philosophy, Bainbridge points out the dramatic effect that gender selection has on people's lives...A fascinating, often humorous analysis of the science of sexuality.
--Gilbert Taylor, Booklist

Reviews of this book:
In The X in Sex, David Bainbridge explains the far-reaching effects of X. Bainbridge...moves with ease between straightforward accounts of biology and historical stories about its effect, like the chapter describing the progression of hemophilia through the royal houses of Europe. Bainbridge discusses cultural history as well as natural history, and his wit enlivens every page.
--Christine Kenneally, New York Times Book Review

Reviews of this book:
There are many literary stars (such as Stephen Jay Gould, Richard Dawkins and Matt Ridley) in the firmament of writers on evolution, and to a man they write with dash and persuasive logic. David Bainbridge is one such and in his latest book he takes the reader through the glories of the X chromosome at a cracking pace.
--Miriam Stoppard, Times Higher Education Supplement (UK)

Reviews of this book:
The truth is that the behaviours of [chromosomes] X and Y are inextricably linked. Bainbridge explores this link in a compelling tale that takes in how the sex chromosomes became sex chromosomes, and the very different consequences of this for women and men. Along the way we encounter the Duke of Kent's testicles, calico cats and non-identical identical twin girls. His story weaves science, history and the history of science (with a little religion for good measure) in a straightforward, anecdotal fashion that will appeal to scientists and non-scientists alike.
--Mark T. Ross, New Scientist (UK)

Reviews of this book:
In his structure/function analysis of the X chromosome, Bainbridge provides a tongue-in-cheek, yet informative, description of one of the two human sex chromosomes.
--R. Adler, Choice

Reviews of this book:
If you have ever been intrigued by some of the puzzles of genetics--why boys tend to get haemophilia or colour blindness while girls are more likely to have an identical twin or to develop rheumatoid arthritis later in life--then The X in Sex is for you.
--Chris Tyler-Smith, Times Literary Supplement

David Bainbridge takes us on a fascinating tour of X chromosomes and explains what the possession of these intricately folded, infinitessimally narrow, two-inch long strings of genetic codes weighing almost nothing, means for their bearers--that is for each one of us, male and female. History and personal anecdotes are woven together with up-to-date summaries of the science, punctuated with Bainbridge's zany--and very British--humor, so that this information-packed book is pure pleasure to read.
--Sarah Blaffer Hrdy author of Mother Nature: A History of Mothers, Infants, and Natural Selection

The X in Sex is absolutely fascinating, so intriguing, in fact, that I found myself unwilling to put it down. David Bainbridge surveys an astonishing amount of new information from recent genomic studies of the X chromosome, clearly explaining the findings in a way the average person can easily follow. The science is presented via amusing and highly appropriate metaphors and clever turns of phrase, all of which serve to brighten the prose and present the reader with catchy ways to think about complex ideas. This is an informative, authoritative, and thoroughly enjoyable read: one of the best books I have read in recent years.
--Jane Lancaster, University of New Mexico

This is wonderful stuff--beautifully written, clear, jargon-free, with anecdotes sure to hold the attention.
--other hupauthorTim Birkhead, author of Promiscuity: An Evolutionary History of Sperm Competition
How to Build a Digital Library reviews knowledge and tools to construct and maintain a digital library, regardless of the size or purpose. A resource for individuals, agencies, and institutions wishing to put this powerful tool to work in their burgeoning information treasuries.

The Second Edition reflects developments in the field as well as in the Greenstone Digital Library open source software. In Part I, the authors have added an entire new chapter on user groups, user support, collaborative browsing, user contributions, and so on. There is also new material on content-based queries, map-based queries, cross-media queries. There is an increased emphasis placed on multimedia by adding a "digitizing" section to each major media type. A new chapter has also been added on "internationalization," which will address Unicode standards, multi-language interfaces and collections, and issues with non-European languages (Chinese, Hindi, etc.).

Part II, the software tools section, has been completely rewritten to reflect the new developments in Greenstone Digital Library Software, an internationally popular open source software tool with a comprehensive graphical facility for creating and maintaining digital libraries.

Outlines the history of libraries on both traditional and digitalWritten for both technical and non-technical audiences and covers the entire spectrum of media, including text, images, audio, video, and related XML standardsWeb-enhanced with software documentation, color illustrations, full-text index, source code, and more
In the new ‘knowledge-intensive economies’ Intellectual assets increasingly play a key part on balance sheets. There is an increasing global awareness that in order to promote innovation and the growth of the economy, businesses must fully recognise and exploit their intellectual assets. A company’s ability to innovate rapidly and successfully is now regarded as essential and most breakthroughs are made by Small and Medium-sized Enterprises (SMEs), usually with no in-house legal professionals to help them. It is essential that those working with or creating intellectual property rights (IPR) are aware of the basics of Intellectual Property Law.

Intellectual Property Asset Management provides business and management students at all levels with an accessible-straight-forward explanation of what the main Intellectual Property rights are and how these rights are protected. Locating the subject squarely in a business context and using case studies and examples throughout drawn from a wide range of business organisations, it explains how an organisation can exploit their rights through licensing, franchising and other means in order to make the best possible use of their IP assets.

This book will provide students with:
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• the tools and understanding to assess an IP breach
• the ability to identify where the problem cannot be solved in house and where expert legal assistance is required
• the knowledge required to work effectively with lawyers and other legal professionals to achieve the desired outcome

A lavishly illustrated compendium of the art and history of animal anatomy from antiquity to today

For more than two thousand years, comparative anatomy—the study of anatomical variation among different animal species—has been used to make arguments in natural philosophy, reinforce religious dogma, and remind us of our own mortality. This stunningly illustrated compendium traces the intertwined intellectual and artistic histories of comparative anatomy from antiquity to today.

Stripped Bare brings together some of the most arresting images ever produced, from the earliest studies of animal form to the technicolor art of computer-generated anatomies. David Bainbridge draws on representative illustrations from different eras to discuss the philosophical, scientific, and artistic milieus from which they emerged. He vividly describes the unique aesthetics of each phase of anatomical endeavor, providing new insights into the exquisite anatomical drawings of Leonardo and Albrecht Dürer in the era before printing, Jean Héroard’s cutting and cataloging of the horse during the age of Louis XIII, the exotic pictorial menageries of the Comte de Buffon in the eighteenth century, anatomical illustrations from Charles Darwin’s voyages, the lavish symmetries of Ernst Haeckel’s prints, and much, much more.

Featuring a wealth of breathtaking color illustrations throughout, Stripped Bare is a panoramic tour of the intricacies of vertebrate life as well as an expansive history of the peculiar and beautiful ways humans have attempted to study and understand the natural world.

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