This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle. The individual chapters will appeal to scientists and clinicians alike.
Discussions of the basic structural, nanotechnology, and system engineering principles, as well as an introductory overview of essential concepts and methods in biotechnology, will be included.Â Text is presented side-by-side with extensive use of high-quality illustrations prepared using cutting edge computer graphics techniques.Â Includes numerous examples, such applications in genetic engineering.Â Represents the only available introduction and overview of this interdisciplinary field, merging the physical and biological sciences.Â Concludes with the authors' expert assessment of the future promise of nanotechnology, from molecular "tinkertoys" to nanomedicine.Â David Goodsell is author of two trade books, Machinery of Life and Our Molecular Nature, and Arthur Olson is the world's leader in molecular graphics and nano-scale representation.
Molecular Nature is a richly illustrated guide to the extraordinary diversity of molecules that are responsible for life. David Goodsell, author of the highly-praised book, The Machinery of Life, has synthesized a vast amount of data in a manner that is accessible to the general reader. Molecular Nature examines topics ranging from the shape of cells to the molecules responsible for digestion, immunity, and thought. The author's unique combination of scientific and artistic talents make this a readable, stimulating and highly evocative book. About the Author: David Goodsell is in the Department of Molecular Biology at the Research Institute of Scripps Clinic in La Jolla, California. His research involves computer graphics and X-ray crystallography. He is the author of The Machinery of Life (Springer-Verlag, 1992), and his artwork has been shown at exhibitions on science and art.
All living cells are made up of an extraordinary collection of tiny molecular machines, which orchestrate the millions of tasks needed for life. Cells build these machines for a variety of purposes: to digest food, to propel them to fertile feeding grounds or away from predators, to store the genetic blueprint, and to fight disease-causing invaders. The Machinery of Life is a journey into the sub-microscopic world of molecular machines. The reader is first introduced to the types of molecules built by cells: proteins, nucleic acids, lipids, and polysaccharides. In a series of distinctive illustrations, the reader is then guided through the interior world of cells, exploring the ways in which molecules work in concert to perform the processes of living. Finally, the book shows how vitamins, viruses, poisons, and drugs each have their effects on the molecules in our bodies. The author and illustrator, David Goodsell, has prepared a fascinating introduction to biochemistry for the nonspecialist. This book combines a clear text with an abundance of drawings and computer graphics that present the world of cells and their components in a new and unique way.
Dieses Buch lädt ein zu einer Reise in das Innere der Zelle. Es zeigt die Vielfalt der Moleküle, die wie die Rädchen einer Maschine ineinandergreifen. Sie sind die Grundlage allen Lebens, von ihrem Funktionieren hängen Gesundheit und Krankheit, Leben und Tod ab. David Goodsell erklärt, was Biochemiker über den Ablauf der lebenswichtigen Prozesse im Körper herausgefunden haben. Den ungeheuren Größenunterschied von unserer vertrauten Welt zur mikroskopisch kleinen Welt der Moleküle überbrückt er dabei durch faszinierende Bilder. Seine Zeichnungen bieten sachliche Informationen über die molekulare Struktur der Zellen und sind zugleich von hohem ästhetischem Reiz.
This book will take an evidence-based approach to current knowledge about biomolecules and their place in our lives, inviting readers to explore how we know what we know, and how current gaps in knowledge may influence the way we approach the information. Biomolecular science is increasingly important in our everyday life, influencing the choices we make about our diet, our health, and our wellness. Often, however, information about biomolecular science is presented as a list of immutable facts, discouraging critical thought. The book will introduce the basic tools of structural biology, supply real-life examples, and encourage critical thought about aspects of biology that are still not fully understood.
Imagine that we had some way to look directly at the molecules in a living organism. An x-ray microscope would do the trick, or since we’re dreaming, perhaps an Asimov-style nanosubmarine (unfortunately, neither is currently feasible). Think of the wonders we could witness firsthand: antibodies atta- ing a virus, electrical signals racing down nerve fibers, proteins building new strands of DNA. Many of the questions puzzling the current cadre of sci- tists would be answered at a glance. But the nanoscale world of molecules is separated from our everyday world of experience by a daunting million-fold difference in size, so the world of molecules is completely invisible. I created the illustrations in this book to help bridge this gulf and allow us to see the molecular structure of cells, if not directly, then in an artistic rendition. I have included two types of illustrations with this goal in mind: watercolor paintings which magnify a small portion of a living cell by one million times, showing the arrangement of molecules inside, and comput- generated pictures, which show the atomic details of individual molecules. In this second edition of The Machinery of Life, these illustrations are presented in full color, and they incorporate many of the exciting scientific advances of the 15 years since the first edition.