Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls.
Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features:Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discoveryStep-by-step descriptions of synthetic methods and practical techniquesExamination of the physical properties for each heterocycle, including NMR data and quantum calculationsDetailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles
Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.
Name Reactions in Heterocyclic Chemistry II presents acomprehensive treatise on name reactions in heterocyclic chemistry,one of the most exciting—and important—fields withinorganic chemistry today.
The book not only covers fresh ground, but also providesextensive information on new and/or expanded reactions in:
Three- and four-membered heterocycles
Five-membered heterocycles (pyrroles and pyrrolidines, indoles,furans, thiophenes, and oxazoles)
Six-membered heterocycles, including pyridines, quinolines, andisoquinolines
Featuring contributions from the leading authorities inheterocyclic chemistry. Each section includes a description of thegiven reaction, as well as the relevant historical perspective,mechanism, variations and improvements, synthetic utilities,experimental details, and references to the current primaryliterature.
The reactions covered in Name Reactions in HeterocyclicChemistry have been widely adopted in all areas of organicsynthesis, from the medicinal/pharmaceutical field, to agriculture,to fine chemicals, and the book brings the most cutting-edgeknowledge to practicing synthetic chemists and students, along withthe tools needed to synthesize new and useful molecules.
This book is an invaluable tool for organic, medicinal and analytical chemists, including those working in biochemistry as well as the petroleum, plastics and pharmaceutical industries. It is also suitable for upper level undergraduates and graduates in organic chemistry, biochemistry and medicinal chemistry.
Unlike other books on name reactions in organic chemistry, Name Reactions, A Collection of Detailed Reaction Mechanisms and Synthetic Applications focuses on the reaction mechanisms. It covers over 320 classical as well as contemporary name reactions.