This is the first book that offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors, biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, prophylactic, therapeutic and countermeasures, and the role of homeland security.Presents a comprehensive look at all aspects of chemical warfare toxicology in one reference work. This saves researchers time in quickly accessing the very latest definitive details on toxicity of specific agents used in chemical warfare as opposed to searching through thousands of journal articles. Will include the most agent-specific information on the marketIncludes detailed coverage of the most exhaustive list of agents possibly used as chemical warfare agents in one source. Section 4: Agents That Can Be Used as Weapons of Mass Destruction ? 25 chapters long. Other books on the market only include a sample selection of specific agents. Offering all possible agents detailed under one cover makes this appealing to a wider audience and saves researchers timeThe Forward will be written by Dr. Tetsuo Satoh, Chiba University, Japan. He is one of the most respected, recognizable authorities on chemical warfare agents which will set the authoritative tone for the bookCovers risk to humans, animals and the environment equally. Researchers involved in assessing the risks involved with a possible chemical warfare attack and those who are developing response plans to such attacks must look at not only the risks to human health but to our wildlife and environment as well. The holistic approach taken in this book ensures that the researchers have ready access to the details no matter which aspect of the effects of CWA's they might be concerned with
In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides.Describes everything you need to know about Organophosphates and CarbamatesExtensively covers pesticides, nerve agents, therapeutic drugs, and flame retardantsDescribes epidemiology of the world's major disasters involving Organophosphates and CarbamatesCovers animal, human, aquatic, and wildlife toxicity of AnticholinesterasesInsights into in-depth cholinergic and noncholinergic mechanisms of toxicityDescribes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesisProvides in vitro and in vivo models for neurotoxicity testingIntegrates knowledge of studies in lab animals and humansOffers risk/safety assessment and national/international guidelines for permissible levels of pesticide residuesDescribes management of Anticholinesterase poisoning in humans
This essential reference then discusses the mechanism of action for the judicious use of these nutraceuticals and the best tools for their evaluation before detailing the safety and toxicity of nutraceuticals and their interactions with other therapeutic drugs.
Finally, and crucially, regulatory aspects from around the world are covered, providing a comprehensive overview of the most effective tools for the evaluation, safety, and toxicity of nutraceuticals, prebiotics, probiotics, and alternative medicines.Grants an overview of the current state-of-the-science of nutraceuticals, their use and applications, and known adverse effectsProvides effective tools to evaluate the potential toxicity of any nutraceuticalIncludes details of regulatory issues as written by international experts
While most comparable texts are primarily directed toward the field of human toxicology, this is the one text needed to thoroughly prepare future veterinarians on the newest approaches for diagnosing poisoning cases in all animals from chemicals and plants of a diverse nature as a result of inadvertent, accidental, or malicious intents. It is thoroughly updated with new chapters and the latest coverage of topics not tackled in any previous books such as target organ toxicity, radiation and radioactive materials, FDA regulatory issues, and ethics in veterinary toxicology. There are also expanded discussions on international topics such as epidemiology of animal poisonings and regulatory guidelines and poisonous plants in Europe. Problem solving strategies are offered for treatment.
This volume will be of interest to practitioners, professors and students of veterinary medicine and veterinary toxicology, poison control centers, marine biologists, environmentalists and animal scientists.Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences librariesNew chapters covering important and timely topics such as melamine and cyanuric acid, toxicogenomics, toxic gases and veterinary medical geologyExpanded look at international topics, such as epidemiology of animal poisonings, regulatory guidelines and poisonous plants in EuropeHeavily contributed book with chapters written by qualified and well-experienced authorities across all areas of veterinary toxicologyProblem solving strategies are offered for treatment as well as in-depth knowledge of the basic mechanisms of veterinary toxicology
Expanding on the ground-breaking first edition, Handbook of Toxicology of Chemical Warfare Agents has been completely updated, presenting the most recent advances in field. Brand new chapters include a case study of the Iran-Iraq war, an overview of chemical weapons of mass destruction, explosives, ricin, the human respiratory system, alternative testing methods, brain injuries, and more.Unites world-leading experts to present cutting-edge, agent-specific information on chemical warfare agents and their adverse effects on human and animal health and the environment.Covers all aspects of chemical warfare agent modes of action, detection, prevention, therapeutic treatment and countermeasures.Features a full update on the first edition to reflect the most recent advances in the field as well as nine new chapters.
With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, also including discussions on reproductive and developmental toxicity in domestic animals, fish, and wildlife.
Completely revised and updated to include the most recent developments in the field, the book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies.Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and developmentIncludes new chapters covering significant developments, such as dose-response assessment for developmental toxicity, juvenile toxicity, and neural tube defects, as well as emerging science, such as stem cell application, toxicoproteomics, metabolomics, endocrine disruption, surveillance and regulatory considerations, and risk assessmentOffers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis