Molecular Pathology of Gynecologic Cancer focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. The volume begins with an explication of the editors’ hypothesis that cancer is mainly a disease of the cell cycle, based on the deregulation of the physiological process of cell reproduction. The following eleven chapters focus on specific issues in gynecologic cancers, including: a proposed model of ovarian serous carcinogenesis, molecular markers for ovarian epithelial cancer, an overview of the pathology of endometrial cancer, molecular genetic aspects of endometrial carcinoma and cervical cancer, a natural history of Human Papilloma Virus (HPV) as it relates to cervical cancer, and hereditary issues in gynecologic cancers. The concluding chapter proposes and outlines a holistic approach to the treatment of female cancer patients. This new volume in Humana’s Current Clinical OncologyTM series will be necessary reading for clinicians and experimental researchers alike.
DIAGNOSIS OF ENDOMETRIAL BIOPSIES, Second Edition, revised and now with color illustrations, continues the tradition as being the most concise and complete diagnostic guide to the endometrial biopsy. A review from MODERN PATHOLOGY praises it as being "extremely useful for the practicing pathologist because it outlines criteria for diagnosis, helps in solving diagnostic diagnostic dilemmas, and clarifies controversial issues." The text is structured to present a logical approach to formulating a pathologic diagnosis from the diverse array of tissue received in the surgical pathology laboratory. Color illustrations show typical artifacts and distortion and explain their impact on diagnostic interpretation. Each chapter includes a section on "Clinical Queries and Reporting" that summarizes the features that must be discussed in the final pathology report. The authors are two prominent gynecologic pathologists, and this book is derived from their long-running Short Course presented at the International Academy of Pathology.
The Bethesda System (TBS) for Reporting CervicaVVaginal Cytologic Diagnoses was developed at a National Cancer Institute (NCI)-sponsored workshop in December 1988 to provide uniform diagnostic terminology that would facilitate communication between the laboratory and the clinician. The format ofTBS report includes a descriptive diagnosis and an evaluation of specimen adequacy. TBS was designed to be flexible so that it could evolve in response to changing needs in cervical cancer screening as well as to advances in the field of cervical pathology. Subsequently, a second workshop was held in April 1991 to evaluate the impact of TBS in actual practice and to amend and modify it where needed. One of the major recommendations of this second meeting was that precise criteria should be formulated for both the diagnostic terms and for the descriptors of specimen adequacy. That is the intended purpose of this monograph. The classification used in TBS is not a histogenetic one, but rather a nomenclature designed to facilitate categorization and reporting of cyto logic diagnoses. The overall diagnosis, as in the World Health Organiza tion (WHO) system, is based on the most abnormal cells present regardless of their number. In addition, it should be noted that the site of origin of an abnormality detected in a cervicaVvaginal cytologic sample cannot always be specified because morphologically identical tumors may arise in the vagina, cervix, endometrium, or ovary.
DIAGNOSIS OF ENDOMETRIAL BIOPSIES presents a logical approach to formulating a pathologic diagnosis from the diverse array of tissue received in the surgical pathology laboratory. The authors are two prominent gynecologic pathologists, and this book is derived from their long-running Short Course presented at the International Academy of Pathology. Illustrations show typical artifacts and distortion and explain their impact on diagnostic interpretation. Each chapter includes a section on "Clinical Queries and Reporting" that summarizes the features that must be discussed in the final pathology report.
Since the publication of the 1/e in 1977, BLAUSTEIN'S PATHOLOGY OF THE FEMALE GENITAL TRACT has consolidated its position as the leading textbook of GYN pathology. It is an essential reference for all pathologists, and an important review aid for GYN residents preparing for their Boards. Includes all-new chapters on cytology, immunohistochemistry, flow cytometry, molecular biology, and epidemiology and biostatistics. Chapters include: Embryology and disorders of abnormal sexual development; nonneoplastic disease of the vulva; neoplastic disease of the vulva; diseases of the vagina; anatomy and histology of the cervix; benign disease of the cervix; HPV infection and precancerous lesions of the cervix; malignant tumors of the cervix; anatomy and histology of the uterine corpus; benign diseases of the endometrium; endometrial hyperplasia and metaplasia; endometrial carcinoma; mesenchymal tumors of the uterus; diseases of the fallopian tube; anatomy and histology of the ovary; nonneoplastic lesions of the ovary; diseases of the peritoneum; common epithelial tumors of the ovary; sex cord-stromal; steroid cell, and other ovarian tumors with endocrine, paraendocrine, and paraneoplastic manifestations; germ cell tumors of the ovary; nonspecific tumors of the ovary, including mesenchylmal tumors and malignant lymphoma; metastatic tumors of the ovary; diseases of the placenta; gestational trophoblastic disease; cytology; immunohistochemistry; flow cytometry; molecular biology; epidemiology and biostatistics; gross description, processing, and reporting of specimens.
This is the third edition of the widely acclaimed Blaustein's Pathology of the Female Genital Tract. The fully illustrated work is an authoritative, comprehensive, and up-to-date textbook and standard reference source in gynecologic and obstetric pathology. It is aimed at practicing pathologists, obstetricians and gynecologists, and residents in these specialties. The book emphasizes the correlation between clinical and pathologic features of female genital tract disease by examining the pathophysiology of individual organ systems. New adjunctive techniques such as immunohistochemistry and molecular DNA analysis are introduced when useful, for example, in the study of premalignant and malignant tumors of cervix and vulva. Blaustein's Pathology of the Female Genital Tract discusses the anatomy, histology and pathology of uterine corpus and ovary, and describes morphologic changes in relation to serum hormone and tissue receptor concentrations; endometrial hyperplasia, metaplasia, and carcinoma; and neoplasia of vulva, vagina, and cervix in connection with human papillomavirus. This book also explores such topics as tract embryology, disorders of normal sexual development, diseases of the placenta, and gestational trophoblastic disease.