The use of cellular transplantation to treat retinal disease has recently become a viable and exciting therapeutic approach. The visibility of the retina and its laminar cellular architecture render it an ideal organ for the development of surgically delivered cellular therapies. Having an in-depth understanding of the current state of cell therapy for the eye is an essential first step toward utilizing similar approaches in other organs. Ophthalmologists, translational clinician-scientists, stem cell scientists, and researchers interested in eye disease will find Cellular Therapies for Retinal Disease: A Strategic Approach essential reading and it is also suitable for workshops or courses at the undergraduate or Ph.D. level.
This volume, as part of the Reliable Lab Solutions series, delivers busy researchers a handy, time-saving source for the best methods and protocols in stem cells.
* Provides powerful research opportunities for those interested in perusing work in pluripotent stem cells, disease modeling, and other aspects of basic stem cell research
* Refines, organizes and updates popular methods from flagship series, Methods in Enzymology
*Highlights top downloads, enhanced with author tips and tricks and pitfalls to avoid
This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and other emerging technologies –such as brain-machine interfaces for controlling bionics and neuroprostheses– is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production. The result is a comprehensive textbook that will be useful to students and experts alike.Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valvesOffers expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systemsFull-color presentation throughout
* Provides complete coverage spanning from derivation/isolation of stem cells, and including differentiation protocols, characterization and maintenance of derivatives and tissue engineering
* Presents the latest most innovative technologies
* Addresses therapeutic relevance including FDA compliance and tissue engineering
* First and most comprehensive book on animal cloning
* Chapters written by the world' expert in each area
* From the early experiments in amphibia to the latest one in mammals, everything is included in this book and told by the researcher that did it and how they did it
* Basic biological mechanisms on how cloning works and all their current and potential applications
* Cloning applications on basic biology, agriculture, biotechnology and medicine are included
* Editors are the pioneers in the field
The organization of the book remains largely unchanged, combining the prerequisites for a general understanding of adult and embryonic stem cells; the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations; as well as a presentation by the world's experts of what is currently known about each specific organ system.
* Full-color presentation througout
* Each chapter begins with 3-5 defined glossary terms, and all of the terms are collected in a comprehensive list within the book
* References have been eliminated - now there are about 10 bibliographic entries per chapter
* Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology
* The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine
* New discoveries from leading researchers on restoration of diseased tissues and organs
But that was just the beginning.
In Beyond Biocentrism, acclaimed biologist Robert Lanza, one of TIME Magazine’s "100 Most Influential People in 2014," and leading astronomer Bob Berman, take the reader on an intellectual thrill-ride as they re-examine everything we thought we knew about life, death, the universe, and the nature of reality itself.
The first step is acknowledging that our existing model of reality is looking increasingly creaky in the face of recent scientific discoveries. Science tells us with some precision that the universe is 26.8 percent dark matter, 68.3 percent dark energy, and only 4.9 percent ordinary matter, but must confess that it doesn’t really know what dark matter is and knows even less about dark energy. Science is increasingly pointing toward an infinite universe but has no ability to explain what that really means. Concepts such as time, space, and even causality are increasingly being demonstrated as meaningless.
All of science is based on information passing through our consciousness but science hasn’t the foggiest idea what consciousness is, and it can’t explain the linkage between subatomic states and observation by conscious observers. Science describes life as an random occurrence in a dead universe but has no real understanding of how life began or why the universe appears to be exquisitely designed for the emergence of life.
The biocentrism theory isn’t a rejection of science. Quite the opposite. Biocentrism challenges us to fully accept the implications of the latest scientific findings in fields ranging from plant biology and cosmology to quantum entanglement and consciousness.
By listening to what the science is telling us, it becomes increasingly clear that life and consciousness are fundamental to any true understanding of the universe. This forces a fundamental rethinking of everything we thought we knew about life, death, and our place in the universe.
This two-volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations, as well as a presentation by the world's experts of what is currently known about each specific organ system.
The editors of the Handbook of Stem Cells include: Robert Lanza, Helen Blau, John Gearhart, Brigid Hogan, Douglas Melton, Malcolm Moore, Roger Pedersen, E. Donnall Thomas, James Thomson, Catherine Verfaillie, Irving Weissman, and Michael West. The Editorial Board includes: W. French Anderson, Peter Andrews, Anthony Atala, Jose Cibelli, Giulio Cossu, Robert Edwards, Martin Evans, Elaine Fuchs, Margaret Fuller, Fred Gage, Richard Gardner, Margaret Goodell, Ronald Green, William Haseltine, Joseph Itskovitz-Eldor, Rudolf Jaenisch, Ihor Lemischka, Dame Anne McLaren, Richard Mulligan, Stuart Orkin, Martin Pera, Benjamin Reubinoff, Janet Rossant, Hans Scholer, Austin Smith, Evan Snyder, Davor Solter, Alan Trounson, and Leonard Zon.
This comprehensive set should be a much-needed addition to the library of students and researchers alike.
* Provides comprehensive coverage on this highly topical subject
* Contains contributions by the foremost authorities and premiere names in the field of stem cell research
* The accompanying CD-ROM includes over 250 color figures
This edition includes greatly expanded focus on stem cells, including adult and embryonic stem cells and progenitor populations that may soon lead to new tissue engineering therapies for heart disease, diabetes, and a wide variety of other diseases that afflict humanity. This up-to-date coverage of stem cell biology and other emerging technologies is complemented by a series of new chapters on recent clinical experience in applying tissue engineering. The result is a comprehensive textbook that we believe will be useful to students and experts alike.
New to this edition:
*Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves
*Expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems
* Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves
* Essential to anyone working in the field
* Educates and directs both the novice and advanced researcher
* Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves
* Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell
* Considered the definitive reference in the field
* List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others
Every now and then a simple yet radical idea shakes the very foundations of knowledge. The startling discovery that the world was not flat challenged and ultimately changed the way people perceived themselves and their relationship with the world. For most humans of the 15th century, the notion of Earth as ball of rock was nonsense. The whole of Western, natural philosophy is undergoing a sea change again, increasingly being forced upon us by the experimental findings of quantum theory, and at the same time, towards doubt and uncertainty in the physical explanations of the universe’s genesis and structure. Biocentrism completes this shift in worldview, turning the planet upside down again with the revolutionary view that life creates the universe instead of the other way around.
In this paradigm, life is not an accidental byproduct of the laws of physics. Biocentrism takes the reader on a seemingly improbable but ultimately inescapable journey through a foreign universe—our own—from the viewpoints of an acclaimed biologist and a leading astronomer. Switching perspective from physics to biology unlocks the cages in which Western science has unwittingly managed to confine itself. Biocentrism will shatter the reader’s ideas of life—time and space, and even death. At the same time it will release us from the dull worldview of life being merely the activity of an admixture of carbon and a few other elements; it suggests the exhilarating possibility that life is fundamentally immortal.
The 21st century is predicted to be the Century of Biology, a shift from the previous century dominated by physics. It seems fitting, then, to begin the century by turning the universe outside-in and unifying the foundations of science with a simple idea discovered by one of the leading life-scientists of our age. Biocentrism awakens in readers a new sense of possibility, and is full of so many shocking new perspectives that the reader will never see reality the same way again.