Modification of existing therapies based on the pursuit of leads arising from mechanistic studies is also being applied clinically on a wide scale. Greater understanding should follow from the studies of reversal of the multidrug resistant phenotype, on the use of hydroxyurea to reverse resistance mediated by extrachromosomal DNA, and on various aspects of the fluoropyrimidine pathways.
Successful applications of chemotherapy to the treatment of specific diseases include the growing applications of systemic therapy using various skin malignancies. In prostate cancer, estramustine phosphate will likely play an expanding role. Taxanes are restructuring treatment regimens in breast cancer, and high-dose strategies are described with peripheral blood progenitor autografting in the treatment of ovarian and breast cancers.
Bleomycin is an integral component of one of the great triumphs of medical oncology—the curative treatment of metastatic testicular carcinomas. Similar curative potential has been demonstrated for bleomycin in combination with cisplatin and vinblastine in germ-cell cancers of the ovary. Bleomycin is included in several important treatment regimens for Hodgkin's disease and non-Hodgkin's lymphomas. The drug also has clinical activity against squamous carcinomas of various sites. These uses and other aspects, including the development of new bleomycin analogs, are discussed in the following chapters, which were first presented at a symposium jointly sponsored by the Northern California Cancer Program and Bristol Laboratories in San Francisco, California, 14-15 September 1984.
Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body.
Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.
Over the past half century, deaths from heart disease, stroke, and so many other killers have fallen dramatically. But cancer continues to kill with abandon. In 2013, despite a four-decade “war” against the disease that has cost hundreds of billions of dollars, more than 1.6 million Americans will be diagnosed with cancer and nearly six hundred thousand will die from it.
A decade ago, Clifton Leaf, a celebrated journalist and a cancer survivor himself, began to investigate why we had made such limited progress fighting this terrifying disease. The result is a gripping narrative that reveals why the public’s immense investment in research has been badly misspent, why scientists seldom collaborate and share their data, why new drugs are so expensive yet routinely fail, and why our best hope for progress—brilliant young scientists—are now abandoning the search for a cure. “Through flowing prose Leaf delivers, alongside facts and data, stories on personalities involved in research, the fascinating process of solving an unusual and highly deadly cancer in Africa, and the heartbreaking realities of cancer treatment in children today. Leaf’s extensively investigated treatise will resonate with researchers and patients frustrated by the bureaucratic woes he delineates. Public policy makers, grant reviewers, and pharmaceutical researchers alike must consider Leaf’s indictment and proposed solutions” (Publishers Weekly). The Truth in Small Doses is that rare tale that will both outrage readers and inspire conversation and change.
The AJCC Cancer Staging Atlas, 2nd Edition, is an official publication of the American Joint Committee on Cancer, the recognized international leader in state-of-the-art information on cancer staging. This Atlas has been created as a companion to the updated 7th Edition of the AJCC Cancer Staging Manual, which continues to disseminate the importance of anatomical and pathological staging in the management of cancer. This state-of-the-art, invaluable 2nd Edition includes a CD containing PowerPoint slides of all illustrations, additional color, and a user-friendly, easy-to-read layout. The AJCC Cancer Staging Atlas, 2nd Edition will serve as an indispensable reference for clinicians, registrars, students, trainees, and patients.
50 Critical Cancer Answers provides the essential information a person needs to create a personal action plan to deal with cancer effectively. Each of the 50 short, easy-to-digest chapters includes a concise explanation of the most effective and sought after cancer treatment in the realms of traditional medicine, natural medicine, emotional support and spiritual care. A succinct commentary is provided to help the reader understand potential benefits, and if it is a realistic treatment option or not. Each chapter includes:
- An interview with an expert in the field of the chapter's topic
- A "smartphone scannable" QR code linking the reader to You Tube video containing author commentary on the relevant topic
- 5 tips from cancer survivors--all 50 cancer survivors have received treatment from the authors' Oasis of Hope cancer centers.
Don't let a cancer diagnosis define your circumstances. Instead, develop a plan to identify, attack, and beat cancer.
Gather step-by-step techniques for assessing and implementing radiotherapeutic options with this comprehensive, full-color, clinically oriented text.
Review the basic principles behind the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, and more.Use new imaging techniques to anatomically locate tumors before and during treatment.
Apply multidisciplinary treatments with advice from experts in medical, surgical, and radiation oncology.
Explore new treatment options such as proton therapy, which can facilitate precise tumor-targeting and reduce damage to healthy tissue and organs.
Stay on the edge of technology with new chapters on IGRT, DNA damage and repair, and molecularly targeted therapies.
Faithful to its title, this text espouses a truly multidisciplinary approach, integrating information from the fields of oncology, neurosurgery, radiation oncology, and neurology. Experts in each specialty have gathered that information which is most important for all physicians caring for patients with brain metastasis.
Brain Metastasis includes complete discussions for all situations in which radiosurgery might be recommended, including for the treatment of gross brain metastasis; for the prevention of tumor-related injury of brain function; and as an alternative to whole-brain radiotherapy.
Features of this uniquely accessible guide include:
A timely discussion of exciting recent developments in aggressive care An emphasis on quality-of-life issues and palliative care Special chapters on radiosurgery for both brain metastasis and spinal tumors Full color insert of high-quality images
This concise and comprehensive text provides a multidisciplinary information source for brain metastasis. It is an essential resource for any practitioner who cares for patients with this devastating yet surprisingly common condition.
Dr. Otis Brawley is the chief medical and scientific officer of The American Cancer Society, an oncologist with a dazzling clinical, research, and policy career. How We Do Harm pulls back the curtain on how medicine is really practiced in America. Brawley tells of doctors who select treatment based on payment they will receive, rather than on demonstrated scientific results; hospitals and pharmaceutical companies that seek out patients to treat even if they are not actually ill (but as long as their insurance will pay); a public primed to swallow the latest pill, no matter the cost; and rising healthcare costs for unnecessary—and often unproven—treatments that we all pay for. Brawley calls for rational healthcare, healthcare drawn from results-based, scientifically justifiable treatments, and not just the peddling of hot new drugs.
Brawley's personal history – from a childhood in the gang-ridden streets of black Detroit, to the green hallways of Grady Memorial Hospital, the largest public hospital in the U.S., to the boardrooms of The American Cancer Society—results in a passionate view of medicine and the politics of illness in America - and a deep understanding of healthcare today. How We Do Harm is his well-reasoned manifesto for change.
Taking a unique multi-disciplinary approach, the book covers conventional histopathology and cytopathology, as well as all important complementary diagnostic tests, such as immunophenotyping (immunohistochemical stains and flow cytometry), karyotyping, FISH and DNA/molecular studies. It offers concise textual and extensive visual coverage of both neoplastic and non-neoplastic hematology disorders, with the neoplastic hematology sections presented according to the most recent WHO classifications. There is also an introduction to the normal structures of hematopoietic tissues and the various multidisciplinary techniques.
The atlas contains more than 900 high-quality color images that mirror the findings that fellows and clinicians encounter in practice. It provides information in a quick, simple and user-friendly manner, attracting those who are in training or are not considered experts in the field. Residents, fellows, practicing clinicians, and researchers in pathology, hematology, hematology/oncology, as well as graduate students in pathology and other clinicians workings in clinical hematology laboratories will all find it useful.Saves clinicians and researchers time in quickly accessing the very latest details on the diverse clinical and scientific aspects of hematopathology, as opposed to searching through thousands of journal articles For clinicians, fellows, and residents, correct diagnosis (and therefore correct treatment) of diseases depends on a strong understanding of the molecular basis for the disease – hematologists, pathologists, oncologists, and other clinicians will benefit from this clear, focused, annotated format
Companion web site features over 900 images from the book!
Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.
Written in joint collaboration by residents and staff radiation oncologists at the Department of Radiation Oncology at the Cleveland Clinic Taussig Cancer Institute, the book contains more than 900 questions addressing the full gamut of the science and practice of radiation oncology today.
Radiation Oncology Self-Assessment Guide Features: Comprehensive coverage of radiation oncologyFlash-card" format facilitates recall of key data, treatment assessment and patient management, and important original studiesOrganized by the major subject areas in radiation oncology, the question sets feature structured questions and nswers designed to test recall and sharpen skillsAuthors are from the Department of Radiation Oncology at the Cleveland Clinic Taussig Cancer Institute
Did you know that you can have breast cancer without having a lump?
Did you know that all breast cancers do not show up on a mammogram or an ultrasound?
Have you ever heard of Inflammatory Breast Cancer?
Nina Anderson, the author of this book, would have answered no to all of the above questions. If she had known some of these facts, she would have been more suspicious about her symptoms. She was a very health conscious individual. She had a mammogram and Pap test every year and did monthly self breast examinations. When she started having swelling, an inverted nipple, redness and a fever in her right breast, the last thing she ever suspected was that she might have breast cancer. She had hardly ever been sick in her entire life until she was diagnosed with this very aggressive and lethal form of breast cancer known as Inflammatory Breast Cancer. This book is the story of her dreadful ordeal and miraculous survival.
Nina considers the sequence of events that led to her early diagnosis a miracle that saved her life. Many women do not survive IBC because there is no lump involved and it cannot be detected by a mammogram or ultrasound. The only way to get a conclusive diagnosis is to perform a surgical biopsy of the breast and skin tissue. The symptoms of Inflammatory Breast Cancer (abbreviated as IBC) are similar to a breast infection known as mastitis. Most women are diagnosed with mastitis or cellulitis and treated with antibiotics for two to three months. By that time IBC is so aggressive that it has spread to other organs of the body and is in the final stage of breast cancer. The details of her diagnosis and the eleven months of treatment that followed are chronicled in this amazing story of survival.
During her very first chemotherapy treatment, an incident involving a bumble bee instilled a hope in Nina that would help to sustain her during the long, grueling months of treatment. She shares her experience in an effort to inform every woman about the symptoms of Inflammatory Breast Cancer and how to cope and fight the disease. It is her hope that this book will save lives. No woman should have to suffer the consequences of this disease because she has never heard of IBC or didnt know about the symptoms. Nina also wants to give every woman who is diagnosed with IBC the hope that YOU CAN SURVIVE.
Here is an excerpt from her book:
CHAPTER ONE THE MONTH OF APRIL
RARE ENCOUNTERS OF THE INTIMATE KIND
You know how when you get past fifty years old, those intimate moments with your spouse are few and far between? Well thats kind of how it was with us. But it was one of those rare evenings when things just seemed to fall in place and it happened! Afterwards my husband, Richard, said that something wasnt right with my right breast. I told him that I had already noticed it and that I thought I might have mastitis. He had no idea what that was, so I explained that it was an infection of the mammary glands which you can sometimes have when you are breastfeeding. I had some redness and swelling and the breast had felt kind of feverish for about a week or two. I told him I guess I would have to make an appointment with my gynecologist and get some antibiotics. It was kind of aggravating to be going through menopause and have to deal with a breast infection. I promised that as much as I hated going to the doctor, I would make an appointment the next day.
When I woke up the next morning, the breast was so swollen that the nipple had inverted. I remembered when I was breast feeding that this same thing had happened when it was feeding time. The breasts would fill with milk and the right nipple would become an inny instead of an outy. I would have to use a nipple shield in order for the baby to be able to n
• Comprehensive information on the many treatment options currently available
• The latest updates on an exciting number of therapies undergoing testing now
• Suggestions to patients to lessen or eliminate treatment side effects
• “Question-and-Answer” format gives direct responses to patient queries
• Health and wellness tips included throughout the book
Arm yourself with a wealth of new information to discuss with your healthcare provider!
* Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors
* Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement
* Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
* Discusses utility of adenoviral vectors in animal disease models
* Considers Federal Drug Administration regulations for human clinical trials
Immunotherapy of Cancerprovides information on cancer research related to inflammation and immunity, containing outstanding reviews by experts in the field. It is suitable for researchers and students who have an interest in cancer immunobiology.Provides information on cancer research, including outstanding and original reviewsCovers the current progress and emerging concepts in cancer inflammation, immunology, and immunotherapy Suitable for researchers and students studying, and interested in, the field of immunotherapy for cancerIdeal for those studying cancer inflammation, tumor immunology, cancer immunotherapy, dendritic cell, antigen presentation, immune checkpoint, myeloid-derived suppressor cells, macrophages, and tumor environments
Since its discovery in 1953 by Watson and Crick, the DNA double helix has been thought of as the language of God. From that point on, throughout the ensuing decades, research has decoded much of that language, giving scientists a more respectable insight into the paradox of life itself. Now, furthering that insight, Dr. Luksas has determined a means of using that language to address cancer and perhaps other diseases.
Providing a wealth of information on DNA and how it functions in the body, as well as other processes important to the replication of cancerous bodies such as cell respiration and metastasis, Dr. Luksas explains his findings with the common reader in mind.
Everything seemed to go on as usual, but nothing was normal anymore. I wanted to shout at everyone, Dont you see life has changed? It will never be the same again?
After surgery, I opted for prosthetics and early on was using the fiber-filled breasts. There was only one problem, and it was major! These things were too light. They kept moving up my body and hitting my chin. This was not going to work.
The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer.Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancerChapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and disseminationFocuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance
Edited by Mukesh G. Harisinghani, MD, with chapter contributions from staff members of the Department of Radiology at Massachusetts General Hospital.
Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer.Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teamsNutritionists and dietitians will gain an understanding of cell signaling, and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods
"...should serve as a standard against which all future atlases will be measured..." -- The New England Journal of Medicine review of an earlier edition
This compact, diagnosis-speeding guide has virtually defined the field of dermatology for thousands of physicians, dermatology residents, and medical students across the globe. Spanning the entire spectrum of skin problems, it combines laser-precise color images of skin lesions with a concise summary outline of dermatologic disorders, along with the cutaneous signs of systemic disease. A color-coded 4-part organization facilitates review at a glance and features helpful icons denoting the incidence and morbidity of disease.
FEATURESMore than 1,000 full-color images--many new to this edition New sections reflect the very latest clinical perspectives on the diagnosis and treatment of all skin disorders shown F ocus on a wide range of skin types highlights skin disease in different ethnic populations Thoroughly updated coverage of etiology, pathogenesis, management, and therapy ICD 9/10 codes included for each disease
Trying to chart a course through the complex task of keeping patient records? Here's your lifeline! Medical Charting Demystified gives you the tools you need to prepare and update both computerized and written charts.
You'll learn about chart components, what to write in a chart, and how to correct errors. Medical Charting Demystified covers entering vital signs, assessments, test results, medications, procedures, patient care plans, and more. Details on the legal aspects of medical charting, including confidentiality, HIPAA, malpractice, and informed consent, are also included. Hundreds of examples and illustrations make it easy to understand the material, and end-of-chapter quizzes and a final exam help reinforce learning.
This fast and easy guide offers:Coverage of the five common charting systems--narrative, problem-oriented, problem-intervention-evaluation, FOCUS, and charting by exception Details on the MAR and the KARDEX An overview of computer charting software A time-saving approach to performing better on an exam or at work
Simple enough for a beginner, but challenging enough for an advanced student, Medical Charting Demystified is your key to mastering this vital nursing skill.
Current, concise, and engagingly written, Morgan & Mikhail’s Clinical Anesthesiology, Fifth Edition is a true essential for all anesthesia students and practitioners. This trusted classic delivers comprehensive coverage of the field’s must-know basic science and clinical topics in a clear, easy-to-understand presentation. Indispensable for coursework, exam review, and as a clinical refresher, this trusted text has been extensively updated to reflect the latest research and developments.
Here’s why Clinical Anesthesiology is the best anesthesiology resource:NEW full-color presentation NEW chapters on the most pertinent topics in anesthesiology, including anesthesia outside of the operating room and a revamped peripheral nerve blocks chapter that details ultrasound-guided regional anesthesia Up-to-date discussion of all relevant areas within anesthesiology, including equipment, pharmacology, regional anesthesia, pathophysiology, pain management, and critical care Case discussions promote application of the concepts to real-world practice Numerous tables and figures encapsulate important information and facilitate memorization
Includes 6 online-only chapters at no additional cost! Go to: www.AccessMedicine.com/CMDT
The book that puts the latest research where it belongs . . . into your practiceWritten by clinicians renowned in their respective fields, CMDT offers the most current insight into symptoms, signs, epidemiology, and treatment for more than 1,000 diseases and disorders. For each topic, you’ll find concise, evidence-based answers to questions about hospital and ambulatory medicine. This streamlined clinical companion is the fastest and easiest way to keep abreast of the latest medical advances, prevention strategies, and cost-effective treatments.
Features and content critical to clinical practice: Strong emphasis on the practical aspects of clinical diagnosis and patient management in all fields of internal medicine Full review of all internal medicine and primary care topics, including gynecology and obstetrics, dermatology, neurology, ophthalmology, geriatrics, and palliative care The only text with an annual review of advances in HIV treatment Specific disease prevention information Drug treatment tables, with indexed trade names and updated prices – plus helpful diagnostic and treatment algorithms Recent references with PMID numbers Six online-only chapters available at no additional cost Full-color photographs and illustrations
NEW TO THIS EDITION: New chapter on Sports Medicine & Outpatient Orthopedics Extensive revision of medical and surgical conditions of pregnancy Updated coverage of evaluating fertility in women, immunization requirements, and the use and safety of nonsteroidal and anti-inflammatory drugs Extensive revision of Kidney Disease chapter New topics include snoring a selection of common musculoskeletal problems such as subacromial impingement syndrome, rotator cuff tear, anterior cruciate ligament and meniscus injuries, patellofemoral pain syndrome, and inversion and eversion ankle sprains New online-only chapter on Women’s Health Issues S.I. units used throughout
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