When twenty-four-year-old Susannah Cahalan woke up alone in a hospital room, strapped to her bed and unable to move or speak, she had no memory of how she’d gotten there. Days earlier, she had been on the threshold of a new, adult life: at the beginning of her first serious relationship and a promising career at a major New York newspaper. Now she was labeled violent, psychotic, a flight risk. What happened?
In a swift and breathtaking narrative, Susannah tells the astonishing true story of her descent into madness, her family’s inspiring faith in her, and the lifesaving diagnosis that nearly didn’t happen. “A fascinating look at the disease that…could have cost this vibrant, vital young woman her life” (People), Brain on Fire is an unforgettable exploration of memory and identity, faith and love, and a profoundly compelling tale of survival and perseverance that is destined to become a classic.
the drama of the front lines.”
-Richard Danzig, former secretary of the navy
The first major bioterror event in the United States-the anthrax attacks in October 2001-was a clarion call for scientists who work with “hot” agents to find ways of protecting civilian populations against biological weapons. In The Demon in the Freezer, his first nonfiction book since The Hot Zone, a #1 New York Times bestseller, Richard Preston takes us into the heart of Usamriid, the United States Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland, once the headquarters of the U.S. biological weapons program and now the epicenter of national biodefense.
Peter Jahrling, the top scientist at Usamriid, a wry virologist who cut his teeth on Ebola, one of the world’s most lethal emerging viruses, has ORCON security clearance that gives him access to top secret information on bioweapons. His most urgent priority is to develop a drug that will take on smallpox-and win. Eradicated from the planet in 1979 in one of the great triumphs of modern science, the smallpox virus now resides, officially, in only two high-security freezers-at the Centers for Disease Control in Atlanta and in Siberia, at a Russian virology institute called Vector. But the demon in the freezer has been set loose. It is almost certain that illegal stocks are in the possession of hostile states, including Iraq and North Korea. Jahrling is haunted by the thought that biologists in secret labs are using genetic engineering to create a new superpox virus, a smallpox resistant to all vaccines.
Usamriid went into a state of Delta Alert on September 11 and activated its emergency response teams when the first anthrax letters were opened in New York and Washington, D.C. Preston reports, in unprecedented detail, on the government’s response to the attacks and takes us into the ongoing FBI investigation. His story is based on interviews with top-level FBI agents and with Dr. Steven Hatfill.
Jahrling is leading a team of scientists doing controversial experiments with live smallpox virus at CDC. Preston takes us into the lab where Jahrling is reawakening smallpox and explains, with cool and devastating precision, what may be at stake if his last bold experiment fails.
• Are you constantly exhausted?
• Do you frequently feel sick?
• Are you hot when others are cold, or cold when everyone else is warm?
• Do you have trouble thinking clearly, aka “brain fog”?
• Do you often feel irritable?
• Are you experiencing hair loss, dry skin, or unexplained weight fluctuation?
• Do your joints ache or swell but you don’t know why?
• Do you have an overall sense of not feeling your best, but it has been going on so long it’s actually normal to you?
IF you answered yes to any of these questions, you may have an autoimmune disease, and this book is the “medicine” you need. Among the most prevalent forms of chronic illness in this country, autoimmune disease affects nearly 23.5 million Americans. This epidemic—a result of the toxins in our diet; exposure to chemicals, heavy metals, and antibiotics; and unprecedented stress levels—has caused millions to suffer from autoimmune conditions such as Graves’ disease, rheumatoid arthritis, Crohn’s disease, celiac disease, lupus, and more. In The Immune System Recovery Plan, Dr. Susan Blum, one of the most sought-after experts in the field of functional medicine, shares the four-step program she used to treat her own serious autoimmune condition and help countless patients reverse their symptoms, heal their immune systems, and prevent future illness.
DR. BLUM’S INNOVATIVE METHOD FOCUSES ON:
• Using food as medicine
• Understanding the stress connection
• Healing your gut and digestive system
• Optimizing liver function
Each of these sections includes an interactive workbook to help you determine and create your own personal treatment program. Also included are recipes for simple, easy-to-prepare dishes to jump-start the healing process.
The Immune System Recovery Plan is a revolutionary way for people to balance their immune systems, transform their health, and live fuller, happier lives.
For more than three decades, millions of consumers have trusted The Pill Book to provide official, FDA-approved information on more than 1,800 of the most commonly prescribed drugs in the United States with guidelines from leading pharmacists. Each drug is profiled in a concise, readable, easy-to-understand entry, making The Pill Book the perfect reference when you have questions about the medications your doctor prescribes. Inside you’ll discover
• generic and brand-name listings that can help you save money
• What each drug is for, and how it works
• usual dosages, and what to do if a dose is skipped
• side effects and possible adverse reactions, highlighted for quick reference
• interactions with other drugs and food
• overdose and addiction potential
• alcohol-free and sugar-free medications
• the most popular self-injected medications and their safe handling
• information for seniors, pregnant and breast-feeding women, children, and others with special needs
• cautions and warnings, and when to call your doctor
• 32 pages of actual-size color photographs of prescription pills*
No home should be without this book!
*Not all ereading devices will show the images in color and at the exact size.
The most up-to-date information about the more than 1,800 most commonly prescribed drugs in the United States:
• Generic and brand-name listings that can help you save money
• What the drug is for, and how it works
• Usual dosages, and what to do if a dose is skipped
• Side effects and possible adverse reactions, highlighted for quick reference
• Interactions with other drugs and food
• Overdose and addiction potential
• Alcohol-free and sugar-free medications
• The most popular self-injected medications and their safe handling
• Information for seniors, pregnant and breast-feeding women, children, and others with special needs
• Cautions and warnings, and when to call your doctor
• 32 pages of actual-size color photographs of prescription pills
From the Trade Paperback edition.
All these problems have been shielded from public scrutiny because they're too complex to capture in a sound bite. But Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct in the medical industry affects us on a global scale.
With Goldacre's characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for regulation. This is the pharmaceutical industry as it has never been seen before.
In this astonishing and startling book, award-winning science and history writer Robert Whitaker investigates a medical mystery: Why has the number of disabled mentally ill in the United States tripled over the past two decades? Every day, 1,100 adults and children are added to the government disability rolls because they have become newly disabled by mental illness, with this epidemic spreading most rapidly among our nation’s children. What is going on?
Anatomy of an Epidemic challenges readers to think through that question themselves. First, Whitaker investigates what is known today about the biological causes of mental disorders. Do psychiatric medications fix “chemical imbalances” in the brain, or do they, in fact, create them? Researchers spent decades studying that question, and by the late 1980s, they had their answer. Readers will be startled—and dismayed—to discover what was reported in the scientific journals.
Then comes the scientific query at the heart of this book: During the past fifty years, when investigators looked at how psychiatric drugs affected long-term outcomes, what did they find? Did they discover that the drugs help people stay well? Function better? Enjoy good physical health? Or did they find that these medications, for some paradoxical reason, increase the likelihood that people will become chronically ill, less able to function well, more prone to physical illness?
This is the first book to look at the merits of psychiatric medications through the prism of long-term results. Are long-term recovery rates higher for medicated or unmedicated schizophrenia patients? Does taking an antidepressant decrease or increase the risk that a depressed person will become disabled by the disorder? Do bipolar patients fare better today than they did forty years ago, or much worse? When the National Institute of Mental Health (NIMH) studied the long-term outcomes of children with ADHD, did they determine that stimulants provide any benefit?
By the end of this review of the outcomes literature, readers are certain to have a haunting question of their own: Why have the results from these long-term studies—all of which point to the same startling conclusion—been kept from the public?
In this compelling history, Whitaker also tells the personal stories of children and adults swept up in this epidemic. Finally, he reports on innovative programs of psychiatric care in Europe and the United States that are producing good long-term outcomes. Our nation has been hit by an epidemic of disabling mental illness, and yet, as Anatomy of an Epidemic reveals, the medical blueprints for curbing that epidemic have already been drawn up.
Doctors have generally overlooked the connections among the 4-A disorders, despite their concurrent rise and the presence of many medical clues. For years the medical establishment has considered autism medically untreatable and utterly incurable, and has limited ADHD treatment mainly to symptom suppression. Dr. Bock and his colleagues, however, have discovered a solution – one that goes to the root of the problem. They have found that deadly modern toxins, nutritional deficiencies, metabolic imbalances, genetic vulnerabilities and assaults on the immune and gastrointestinal systems trigger most of the symptoms of the 4-A disorders, resulting in frequent misdiagnosis and untold misery.
Dr. Bock’s remarkable Healing Program, drawing on medical research and based on years of clinical success, offers a safe, sensible solution that is individualized to each child to help remedy these root causes. The biomedical approach to autism, ADHD, and the other 4-A epidemics, as innovated by Dr. Bock and some of America’s finest integrative physicians, is one of the most promising and exciting medical movements of our time.
In this eminently readable account, written by Dr. Bock in collaboration with critically acclaimed author Cameron Stauth, you will meet children and parents whose dramatic stories will inspire you to change the life of your own child. This program may be the help that you have been praying for.
From the Hardcover edition.
World-renowned endocrinologist Dr. Ridha Arem has treated hundreds of patients successfully for hormone-related weight problems—and almost every weight problem has an accompanying hormone problem. Now for the first time in The Thyroid Solution Diet, Dr. Arem makes his comprehensive hormone-balancing nutrition and weight-loss plan available to the public. With it, you will restore your health and feel better— mentally and physically—as you get slimmer.
Dr. Arem perfected his unique diet after extensive research, modifying the Mediterranean Diet so that his plan is higher in protein, higher in fiber, and also low-glycemic. This way your meals are both satisfying and filling. Specific combinations of proteins and essential supplements at each meal rev your metabolism and reverse hormonal imbalances. And you can further personalize your weight-loss plan by choosing from Dr. Arem’s extensive lists of Favorite Foods and from 48 delicious recipes created especially for this book.
Before you even start the diet, Dr. Arem takes you through a weeklong detox plan to rid your body of the environmental toxins that compromise your hormone functions and contribute to making you fat. You’ll make his carefully formulated smoothie and also start to work with the illustrated 20/10 Exercise program—twenty minutes of aerobics and ten minutes of strength training—to generate energy and vitality.
Retrain your body, ramp up your energy, sleep better, reduce stress, and—finally—lose weight and keep it off. This comprehensive mind-body health and diet plan can help you.
From The Thyroid Solution Diet
Do you want to lose weight? Have you tried diet after diet and yet the stubborn pounds remain? Regardless of why you gained weight, once you’re wearing those extra pounds, your metabolism shifts gears, triggering multiple hormonal changes that perpetuate weight gain by making your body resistant to losing weight. The only way to lose weight is to rebalance your hormone systems, and the Thyroid Solution Diet is meticulously crafted to do just that.
Ask yourself these questions: Are you always tired? Do you have dry skin and dry hair? Is your hair thinning? Are your hands and feet always cold? Do you have a lack of motivation or are you moody, anxious, irritable, or depressed? A thyroid imbalance could be causing any of these symptoms . . . and your weight gain, too. For decades, researchers knew that the thyroid, a butterfly-shaped gland at the front of the neck, governed metabolism, mood, body fat, brain function, and even hearing and vision. But the details on how thyroid hormones control appetite, energy, and weight weren’t clear until recently. Even if you haven’t been diagnosed with a thyroid condition, or your doctor has told you your blood tests are normal, you might have a subclinical thyroid imbalance, meaning your blood tests are minimally abnormal or borderline. Many doctors ignore these small abnormalities, but losing weight with a borderline low thyroid condition is extremely difficult.
Each chapter of this engaging and unique book focuses on one inevitable ingredient of childhood--everything from pizza to laundry to homework to the "Big Talk"--and explores the underlying social, political, and ecological forces behind it. Through these everyday moments, Steingraber demonstrates how closely the private, intimate world of parenting connects to the public world of policy-making and how the ongoing environmental crisis is, fundamentally, a crisis of family life.
PTCE (Pharmacy Technician Certification Exam) Flashcard Book
400 Questions & Answers You Need to Know
Written by a seasoned pharmacy technician instructor, this PTCE study supplement covers everything you need to know for the exam: assisting the pharmacist in serving patients, maintaining medication and inventory control systems, and participating in the management of pharmacy practice.
The 400 flashcards are broken down by PTCE test topics and include multiple-choice questions with detailed answers. We give you:
100 flashcards focused on the top 100 brand/generic drug names including their drug classes, indications, side effects, and special considerations;
50 flashcards focused on pharmaceutical terms and abbreviations and
250 flashcards focused on PTCE review material: Assisting the Pharmacist in Serving Patients (165 flashcards), Maintaining Medication and Inventory Control Systems (50 flashcards), and Participating in the Administration and Management of Pharmacy Practice (30 flashcards).
After studying with the book, review what you've learned at REA's online Study Center. Customizable e-flashcards and 3 practice quizzes let you create your own PTCE study plan and study anywhere, anytime. You can also make your own flashcards for any topics that give you difficulty.
If you're a pharmacy tech student and want extra practice and review before the exam, REA's PTCE Flashcard Book is the right Rx for your study needs.
· cope with the diagnosis and adjust to the disease’s progression
· help the patient talk about the illness
· face the issue of driving
· make meals and bath times as pleasant as possible
· adjust room design for the patient’s comfort
· deal with wandering, paranoia, and aggression
This remarkable medical parallel launched Natterson-Horowitz on a journey of discovery that reshaped her entire approach to medicine. She began to search for other connections between the human and animal worlds: Do animals get breast cancer, anxiety-induced fainting spells, sexually transmitted diseases? Do they suffer from obsessive-compulsive disorder, bulimia, addiction?
The answers were astonishing. Dinosaurs suffered from brain cancer. Koalas catch chlamydia. Reindeer seek narcotic escape in hallucinogenic mushrooms. Stallions self-mutilate. Gorillas experience clinical depression.
Joining forces with science journalist Kathryn Bowers, Natterson-Horowitz employs fascinating case studies and meticulous scholarship to present a revelatory understanding of what animals can teach us about the human body and mind. “Zoobiquity” is the term the authors have coined to refer to a new, species-spanning approach to health. Delving into evolution, anthropology, sociology, biology, veterinary science, and zoology, they break down the walls between disciplines, redefining the boundaries of medicine.
Zoobiquity explores how animal and human commonality can be used to diagnose, treat, and heal patients of all species. Both authoritative and accessible, offering cutting-edge research through captivating narratives, this provocative book encourages us to see our essential connection to all living beings.
This plain-English guide is fully updated with the latest fibromyalgia treatment options, and evaluations of new medications that have shown great promise in reducing pain. You'll discover how to spot an array of symptoms and their possible causes, work with your physician to develop a treatment plan, and manage your pain at home and in the office. You'll learn how to:Identify your FMS trigger points Cope with chronic pain and sleep problems Find medications that work for you Locate a physician who can really help you Make healing lifestyle changes Use hands-on therapies to alleviate pain Find effective over-the-counter and prescription medications Choose among alternative therapies and treatments Reduce the emotional distress caused by FMS Help a child with FMS
Featuring moving and inspiring stories from fellow FMS sufferers who share their stories and offer invaluable tips on working your way back to wellness, Fibromyalgia for Dummies, Second Edition offers serious and sensitive guidance to help you overcome FMS and start being yourself again.
You may not know that you have Lyme. It can mimic every disease process including Chronic Fatigue Syndrome, Fibromyalgia, autoimmune conditions like MS, psychiatric conditions like depression and anxiety, and cause significant memory and concentration problems, mimicking early dementia. It is called the "Great Imitator," and inaccurate testing-combined with a fierce, ongoing debate that questions chronic infection-makes it difficult for sufferers to find effective care.
When Dr. Richard Horowitz moved to the Hudson Valley over two decades ago to start his own medical practice, he had no idea that he was jumping into a hotbed of Lyme disease. He would soon realize that many of the chronic disease diagnoses people were receiving were also the result of Lyme-and he would discover how once-treatable infections, in the absence of timely intervention, could cause disabling conditions. In a field where the number of cases is growing exponentially around the world and answers remain elusive, Dr. Horowitz has treated over 12,000 patients and made extraordinary progress. His plan represents a crucial paradigm shift, without which the suffering will continue.
In this book, Dr. Horowitz:
- Breaks new ground with a 16 Point Differential Diagnostic Map, the basis for his revolutionary Lyme treatment plan, and an overarching approach to treating all chronic illness.
- Introduces MSIDS, or Multiple Systemic Infectious Disease Syndrome, a new lens on chronic illness that may prove to be an important missing link.
- Covers in detail Lyme's leading symptoms and co-infections, including immune dysfunction, sleep disorders, chronic pain and neurodegenerative disorders - providing a unique functional and integrative health care model, based on the most up-to-date scientific research, for physicians and health care providers to effectively treat Lyme and other chronic illnesses.
Cutting through the frustration, misinformation and endless questions, Dr. Horowitz's enlightening story of medical discovery, science and politics is an all-in-one source for patients of chronic illness to identify their own symptoms and work with their doctors for the best possible treatment outcome.
The book will affect readers on rational and emotional planes. It is grounded in both a New Age spiritual sensibility and hard science. While some of the author's claims may strike traditional thinkers as outlandish, Buhner presents his arguments with such authority and documentation that the scientific underpinnings, however unconventional, are completely credible.
The overall impact is a powerful, eye-opening expos' of the threat that our allopathic Western medical system, in combination with our unquestioning faith in science and technology, poses to the primary life-support systems of the planet. At a time when we are preoccupied with the terrorist attacks and the possibility of biological warfare, perhaps it is time to listen to the planet. This book is essential reading for anyone concerned about the state of the environment, the state of health care, and our cultural sanity.
Wheat Belly Total Health is about regaining full metabolic well being, reflected in blood sugar and other measures that may require additional steps beyond grain elimination. This book is your guide on the journey to long-term health and vitality--and it will be the only book you ever need to break the grip of wheat, lose weight for good, and achieve vibrant, lasting health.
The last thing Lisa Lynch had expected to put on her 'things to do before you're 30' list was beating breast cancer, but them's the breaks. So with her life on hold, and her mind stuffed with unspoken fears, questions and emotions, she turned to her computer and started blogging about the frustrating, life-altering, sheer pain-in-the-arse inconvenience of getting breast cancer at the age of 28.
The C-Word is an unflinchingly honest and darkly humorous account of Lisa's battle with The Bullshit, as she came to call it. From the good days when she could almost pretend it wasn't happening, to the bad days, when she couldn't bear to wake up, Lisa's story is emotional, heartbreaking and often hilarious. The C-Word will make you laugh and cry, and ultimately reaffirm your faith in life.
NEW TO THIS EDITION:Three new chapters including new information on men’s health, women’s health, and pharmacogenomics and laboratory tests.Mini-cases embedded in each chapter provide therapy-related examples and reinforce important points made in the text.Quickview Charts give an overview of important clinical information including reference ranges and critical values.Learning Points focus on a clinical application of a major concept present in the chapter.
TechPrep™ contains more than 1,000 review questions to help readers prepare for national technician certification exams. A robust Practice Session feature allows users to create custom quizzes by setting topic area, time, and number of questions. The Simulated Exam function lets readers practice their test skills by providing a 90 question, 120 minute test, with questions weighted to mimic national certification exams. Students using TechPrep™ receive instant, automated scoring, and can quickly identify areas they’ve mastered, or practice subjects where they need improvement. Alone or with the new edition of the Manual for Pharmacy Technicians, 4th Edition andall-new Workbook for the Manual for Pharmacy Technicians, the Pharmacy Technician Review Guide and Practice Exam offers the most comprehensive review to help you achieve certification!
Includes DVD with image bank
A Doody's Core Title ESSENTIAL PURCHASE for 2011!
4 STAR DOODY'S REVIEW!
"This 12th edition of the most authoritative book in pharmacology is the best both in content and physical appearance....This edition of Goodman & Gilman's continues to be the most authoritative and widely used resource bridging the discipline of pharmacology with therapeutics. Moreover, readers will find this edition to be substantially improved from past editions in both content and physical appearance."--Doody's Review Service
The most universally respected and read medical text in all of pharmacology, Goodman & Gilman’s The Pharmacological Basis of Therapeutics represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease.
Enriched by a new full-color presentation and updated to reflect all critical new developments in drug action and drug-disease interaction, the twelfth edition includes more than 440 color illustrations depicting key principles and actions of specific pathways and therapeutic agents. The companion DVD includes all the images and tables in the text along with narrated animations.
Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12e is divided into nine sections, covering:
More than a textbook, Goodman & Gilman's is a working template for the effective and rational prescribing of drugs in daily practice.
updated and streamlined for today’s students and clinicians
The only place you can get ALL the great content found in the two print volumes AND the acclaimed DVD in one convenient resource!
Through six decades, no resource has matched the authority, esteemed scholarship, and scientific rigor of Harrison’s Principles of Internal Medicine. Capturing the countless advances and developments across the full span of medicine, the new 19th edition of Harrison’s provides a complete update of essential content related to disease pathogenesis, clinical trials, current diagnostic methods and imaging approaches, evidence-based practice guidelines, and established and newly approved treatment methods.
Here are just a few of the outstanding features of the new Nineteenth Edition:Content is practically organized around two basic themes: education and clinical practice The teaching and learning sections cover foundational principles, cardinal manifestations of disease and approach to differential diagnosis; the content devoted to clinical practice focuses on disease pathogenesis and treatment NEW chapters on important topics such as Men’s Health, The Impact of Global Warming on Infectious Diseases, Fatigue, and many more Critical updates in management and therapeutics in Hepatitis, Coronary Artery Disease, Ebola Virus Disease, Multiple Sclerosis, Diabetes, Hypertension, Deep Vein Thrombosis and Pulmonary Embolism, Acute and Chronic Kidney Disease, Inflammatory Bowel Disease, Lipoprotein Disorders, HIV and AIDS, and more. Increased number of the popular Harrison’s clinical algorithms; clinically relevant radiographic examples spanning hundreds of diseases; clinical-pathological images in full color; crystal clear, full color drawings and illustrations and helpful tables and summary lists that make clinical application of the content faster than ever Outstanding multi-media resources including practical videos demonstrating essential bedside procedures, physical examination techniques, endoscopic findings, cardiovascular findings, are available for easy download
Supporting the renowned coverage are supplemental resources that reflect and assist modern medical practice: more than 1,000 full-color photographs to aid visual recognition skills, hundreds of state-of-the-art radiographs, from plain film to 3D CT to PET Scans; beautiful illustrations that bring applied anatomy and processes to life; the renowned Harrison’s patient-care algorithms, essential summary tables, and practical demonstrative videos. In addition, several digital atlases highlight noninvasive imaging, percutaneous revascularization, gastrointestinal endoscopy, diagnosis and management of vasculitis, and numerous other issues commonly encountered in clinical practice.
Acclaim for Harrison’s:
“Covering nearly every possible topic in the field of medicine, the book begins with a phenomenal overview of clinical medicine, discussing important topics such as global medicine, decision-making in clinical practice, the concepts of disease screening and prevention, as well as the importance of medical disorders in specific groups (e.g. women, surgical patients, end of life). The extensive chapters that follow focus on a symptom-based presentation of disease and then illness organized by organ system. Numerous tables, graphs, and figures add further clarity to the text."
...Written by experts in the field, this book is updated with the latest advances in pathophysiology and treatment. It is organized in a way that makes reading from beginning to end a logical journey, yet each chapter can stand alone as a quick reference on a particular topic. “
Doody’s Review Service reviewing the previous edition of Harrison’s
Government Is Us 2.0 picks up where the previous edition left off. It addresses the bigger questions that are being asked and discussed about the relationships among and between citizens and their governments, how individuals and agencies govern, and the institutional elements that keep us from engendering long-term, socially just participatory change.
The central argument of Government Is Us 2.0 is that much can be done to bridge the gulf between citizens and their governments. The chapter authors offer practical suggestions on how public administrators can productively involve citizens in government work, with steps that will increase citizens' trust in government through opportunities for direct connection and collaboration.
In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group.
Key features include:
• Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups.
• How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism.
• Numerous examples and expanded discussions for complex concepts.
• Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice.
• An overview of structure activity relationships (SARs) and concepts that govern drug design.
• Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix.
Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry.
About the Authors
Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy.
Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.
Your biography becomes your biology. The emotional trauma we suffer as children not only shapes our emotional lives as adults, but it also affects our physical health, longevity, and overall wellbeing. Scientists now know on a bio-chemical level exactly how parents’ chronic fights, divorce, death in the family, being bullied or hazed, and growing up with a hypercritical, alcoholic, or mentally ill parent can leave permanent, physical “fingerprints” on our brains.
When children encounter sudden or chronic adversity, stress hormones cause powerful changes in the body, altering the body’s chemistry. The developing immune system and brain react to this chemical barrage by permanently resetting children’s stress response to “high,” which in turn can have a devastating impact on their mental and physical health as they grow up.
Donna Jackson Nakazawa shares stories from people who have recognized and overcome their adverse experiences, shows why some children are more immune to stress than others, and explains why women are at particular risk. “Groundbreaking” (Tara Brach, PhD, author of Radical Acceptance) in its research, inspiring in its clarity, Childhood Disrupted explains how you can reset your biology—and help your loved ones find ways to heal. “A truly important gift of understanding—illuminates the heartbreaking costs of childhood trauma and like good medicine offers the promising science of healing and prevention” (Jack Kornfield, author of A Path With Heart).
In his new book, The Simple Heart Cure, you’ll find this top doc’s groundbreaking approach to preventing and reversing heart disease — an approach honed by his study of foreign cultures free of heart disease and decades of experience helping patients achieve a healthier heart at any age.
Dr. Crandall is living proof of his program’s success. At the age of 48, and with no major risk factors, he found himself in the ER with a “widow-maker” blockage of his main coronary artery. After emergency heart surgery, he recovered from heart disease using the same course of treatment he recommends to his thousands of patients — and details for your benefit — in The Simple Heart Cure.
His unique perspective as both doctor and patient helps him empathize with the difficulties in making a transition from years of bad habits to a heart-healthy way of life. Plus, Dr. Crandall believes in using every weapon in his medical arsenal — conventional medicine, emerging treatments, lifestyle changes, even alternative therapies — to help his patients recover.
Here are just a few of the potentially life-saving gems you’ll discover:
• Proven ways to banish bad cholesterol
• How to slash your risk of a deadly heart attack by 61%
• 8 easy steps to head off that high blood pressure
• How you can safeguard against stroke
• Simple strategies to unclog your arteries without surgery
• What your belly says about your heart health
• Must-have heart tests for everyone over 50
• Easy solutions to steer clear of statin drugs, and much more...
So whether you just want to prevent heart problems, or you’ve already had a heart attack, you’ll find the help you need in The Simple Heart Cure, along with tasty, heart-healthy menus and a 90-day week-by-week plan to help you start taking action immediately.
In The Disease Delusion, Dr. Bland explains what Functional Medicine is and what it can do for you. While advances in modern science have nearly doubled our lifespans in only four generations, our quality of life has not reached its full potential. Outlining the reasons why we suffer chronic diseases from asthma and diabetes to obesity, arthritis and cancer to a host of other ailments, Dr. Bland offers achievable, science-based solutions that can alleviate these common conditions and offers a roadmap for a lifetime of wellness.
DMSO is a natural chemical compound derived from trees as a by-product from paper manufacturing. DMSO has been called a new medical principle and a true wonder drug. It has proven effective, either by itself or in combination with other products in the treatment of nearly every ailment known.
There has been much controversy about DMSO over the last 50 years. It is one of the most studied medical products ever. Thousands of scientific articles have been written about DMSO. When used properly it is one of the safest products know. It is also very cheap to produce.
This book provides the documentation needed to show that DMSO is probably the most important product ever for the relief of human suffering.
******Archie is quite clearly a leading authorithy on DMSO. He has extensive knowledge and experience regarding the clinical benefits of DMSO treatment. For decades, Archie has studied and worked with DMSO. He understands the safety, utility and efficaciousness of DMSO. I highly recommend this book for anyone interested in health, especially for those who want to learn more about non toxic medical therapies. For individuals with certain health ailments, DMSO could prove quite benefical. -Daniel Junck, MD
Living with Crohn’s & Colitis offers patient-focused, expert guidance on everything from the latest medical treatments, how to cope with a diagnosis, and tips for balancing diet with a busy lifestyle so you can form a personalized wellness plan.
Living with Crohn’s & Colitis also includes:
· Easy to understand information on the role of inflammation and the immune system on gut health
· Traditional and alternative treatment options for a broad, full-body approach to wellness
· A 3-month wellness plan adjustable to each individual’s health needs
· Over 25 delicious recipes designed for those with IBD
Learning to live with the myriad aspects of Crohn’s and ulcerative colitis treatment, including dietary restrictions and medications, can seem overwhelming. Written by a naturopathic doctor and a Crohn’s patient, Living with Crohn’s & Colitis is a thoughtful, balanced resource to help you on your journey to wellness.
From the Trade Paperback edition.
Miranda Esmonde-White trains everyone from prima ballerinas to professional hockey players to Cerebral palsy patients: what do they all have in common? All of these people are hoping to heal their bodies, prevent further injury, and move optimally and without pain. In fact, they have the same goals as any of us who are trying to stay young, fit, and reverse the hands of time.
Because the aging of our bodies occurs in our cells, it must be repaired there too—that’s where Miranda’s highly effective and sought-after techniques come in. The body is programmed to self-destruct as we age, but the speed at which it self-destructs is up to us. Recent scientific studies have proven this fact! In Aging Backwards, Miranda offers a groundbreaking guide on how to maintain and repair our cells, through scientifically designed workouts.
Healthy cells prevent joint pain, muscle loss and weak bones—helping to control weight, increase energy, and improve strength and mobility. Miranda offers readers of all ages the tools they need to look and feel young. Complete with tips, tools, and her Eight Basic Age-Reversing Workouts accompanied by instructional photos and web clips, Aging Backwards will help you grow younger, not older!
Why do you fall in love with one person rather than another? In this fascinating and informative book, Helen Fisher, one of the world's leading experts on romantic love, unlocks the hidden code of desire and attachment. Each of us, it turns out, primarily expresses one of four broad personality types—Explorer, Builder, Director, or Negotiator—and each of these types is governed by different chemical systems in the brain. Driven by this biology, we are attracted to partners who both mirror and complement our own personality type.
Until now the search for love has been blind, but Fisher pulls back the curtain and reveals how we unconsciously go about finding the right match. Drawing on her unique study of 40,000 men and women, she explores each personality type in detail and shows you how to identify your own type. Then she explains why some types match up well, whereas others are problematic. (Note to Explorers: be prepared for a wild ride when you hitch your star to a fellow Explorer!) Ultimately, Fisher's investigation into the complex nature of romance and attachment leads to astonishing new insights into the essence of dating, love, and marriage.
Based on entirely new research—including a detailed questionnaire completed by seven million people in thirty-three countries—Why Him? Why Her? will change your understanding of why you love him (or her) and help you use nature's chemistry to find and keep your life partner.
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In The Fever, the journalist Sonia Shah sets out to answer these questions, delivering a timely, inquisitive chronicle of the illness and its influence on human lives. Through the centuries, she finds, we've invested our hopes in a panoply of drugs and technologies, and invariably those hopes have been dashed. From the settling of the New World to the construction of the Panama Canal, through wars and the advances of the Industrial Revolution, Shah tracks malaria's jagged ascent and the tragedies in its wake, revealing a parasite every bit as persistent as the insects that carry it. With distinguished prose and original reporting from Panama, Malawi, Cameroon, India, and elsewhere, The Fever captures the curiously fascinating, devastating history of this long-standing thorn in the side of humanity.
Each chapter contains learning objectives, case studies, bibliographies, and charts that summarize the causes of high and low test results.
New for this edition: Updated and expanded Quick View tables in each chapter now match those in the popular quick-reference, Interpreting Laboratory Data: A Point-of-Care Guide New glossary of acronyms is right up front for a streamlined reference Normal value ranges of all tests have been standardized by an expert pathologist New and updated cases in each chapter apply your Basic Skills in clinical situations Reorganized to highlight the application of concepts by body system, and in special populationsBasic Skills in Interpreting Laboratory Data offers features that will help pharmacy students not only understand and engage with the material but also will streamline the transition from classroom to practice setting. After studying with this trusted text, students and pharmacists will more effectively monitor patient therapy, evaluate test results, and improve outcomes through optimal and focused pharmacotherapy.
Challenging the accepted methodologies of epidemiology and international health, he points out that most current explanatory strategies, from "cost-effectiveness" to patient "noncompliance," inevitably lead to blaming the victims. In reality, larger forces, global as well as local, determine why some people are sick and others are shielded from risk. Yet this moving account is far from a hopeless inventory of insoluble problems. Farmer writes of what can be done in the face of seemingly overwhelming odds, by physicians determined to treat those in need. Infections and Inequalities weds meticulous scholarship with a passion for solutions—remedies for the plagues of the poor and the social maladies that have sustained them.
Pharmacotherapy Handbook, 8e provides practitioners and students with the critical information necessary to support drug therapy decision making for more than 140 diseases and disorders. Featuring a convenient alphabetized presentation, this handy guide utilizes tables, texts, figures, and treatment algorithms to make the information readily accessible and easily understood.
The consistent chapter organization includes: Disease state definition Review of relevant pathophysiology Clinical presentation Diagnosis Desired outcome Treatment Monitoring
The Treatment section usually includes nonpharmacologic therapy, drug selection guidelines, dosing recommendations, adverse effects, pharmacokinetic considerations, and important drug interactions.
From Abilify to Zyrtec and nearly every drug in between, Mosby's Drug Reference for Health Professions, 3rd Edition is the must-have item for every aspiring health professional. In fact, it's the only drug book on the market written specifically for health professionals! Filled with vital details your students need to know about patient medications, this updated edition features concise, reliable information that is easy to navigate and simple to follow. Key details are presented in short monographs for 1,000 generic drugs (including 4,500 trade-name drugs) that are listed alphabetically. Precautions and considerations sections are tailored to circumstances your students will face on the job. Make certain they have the most relevant information on hand for their studies and for clinical practice with Mosby's Drug Reference for Health Professions, 3rd Edition!
A handsome man contracts Chicken Pox and ends up looking like the victim of a third degree burn.
A vigorous young athlete is bitten by an insect and becomes a target for flesh-eating strep.
Even the most innocuous everyday activities such as eating a salad for lunch, getting bitten by an insect, and swimming in the sea bring human beings into contact with dangerous, often deadly microorganisms. In The Woman with a Worm in Her Head, Dr. Pamela Nagami reveals-through real-life cases-the sobering facts about some of the world's most horrific diseases: the warning signs, the consequences, treatments, and most compellingly, what it feels like to make medical and ethical decisions that can mean the difference between life and death.
Unfailingly precise, calmly instructive, and absolutely engrossing, The Woman with the Worm in Her Head offers both useful information and enjoyable reading.
What happens when you eat an apple? The answer is vastly more complex than you imagine.
Every apple contains thousands of antioxidants whose names, beyond a few like vitamin C, are unfamiliar to us, and each of these powerful chemicals has the potential to play an important role in supporting our health. They impact thousands upon thousands of metabolic reactions inside the human body. But calculating the specific influence of each of these chemicals isn’t nearly sufficient to explain the effect of the apple as a whole. Because almost every chemical can affect every other chemical, there is an almost infinite number of possible biological consequences.
And that’s just from an apple.
Nutritional science, long stuck in a reductionist mindset, is at the cusp of a revolution. The traditional “gold standard” of nutrition research has been to study one chemical at a time in an attempt to determine its particular impact on the human body. These sorts of studies are helpful to food companies trying to prove there is a chemical in milk or pre-packaged dinners that is “good” for us, but they provide little insight into the complexity of what actually happens in our bodies or how those chemicals contribute to our health.
In The China Study, T. Colin Campbell (alongside his son, Thomas M. Campbell) revolutionized the way we think about our food with the evidence that a whole food, plant-based diet is the healthiest way to eat. Now, in Whole, he explains the science behind that evidence, the ways our current scientific paradigm ignores the fascinating complexity of the human body, and why, if we have such overwhelming evidence that everything we think we know about nutrition is wrong, our eating habits haven’t changed.
Whole is an eye-opening, paradigm-changing journey through cutting-edge thinking on nutrition, a scientific tour de force with powerful implications for our health and for our world.
Topics covered include Cardiovascular Disease, Endocrinology & Metabolism, Gastroenterology, General Internal Medicine, Hematology, Infectious Disease, Nephrology / Urology, Oncology, Neurology, Dermatology, Pulmonary Disease & Critical Care, Rheumatology / Orthopedics
The book also contains 2 bonus chapters on how to study for the ABIM Internal Medicine Exam and the NBME Internal Medicine Shelf Exam.
For more information visit www.knowmedge.com
Includes 6 online-only chapters at no additional cost! Go to: www.AccessMedicine.com/CMDT
The book that puts the latest research where it belongs . . . into your practiceWritten by clinicians renowned in their respective fields, CMDT offers the most current insight into symptoms, signs, epidemiology, and treatment for more than 1,000 diseases and disorders. For each topic, you’ll find concise, evidence-based answers to questions about hospital and ambulatory medicine. This streamlined clinical companion is the fastest and easiest way to keep abreast of the latest medical advances, prevention strategies, and cost-effective treatments.
Features and content critical to clinical practice: Strong emphasis on the practical aspects of clinical diagnosis and patient management in all fields of internal medicine Full review of all internal medicine and primary care topics, including gynecology and obstetrics, dermatology, neurology, ophthalmology, geriatrics, and palliative care The only text with an annual review of advances in HIV treatment Specific disease prevention information Drug treatment tables, with indexed trade names and updated prices – plus helpful diagnostic and treatment algorithms Recent references with PMID numbers Six online-only chapters available at no additional cost Full-color photographs and illustrations
NEW TO THIS EDITION: New chapter on Sports Medicine & Outpatient Orthopedics Extensive revision of medical and surgical conditions of pregnancy Updated coverage of evaluating fertility in women, immunization requirements, and the use and safety of nonsteroidal and anti-inflammatory drugs Extensive revision of Kidney Disease chapter New topics include snoring a selection of common musculoskeletal problems such as subacromial impingement syndrome, rotator cuff tear, anterior cruciate ligament and meniscus injuries, patellofemoral pain syndrome, and inversion and eversion ankle sprains New online-only chapter on Women’s Health Issues S.I. units used throughout
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