This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage.
This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries.Updates to all chapters, including new examples and referencesChapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the bookChapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistryChapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexantChapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesisChapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinibfor transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazidfor slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptinChapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examplesChapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolitesChapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
See how chemistry works in everything from soaps to medicines to petroleum
We're all natural born chemists. Every time we cook, clean, take a shower, drive a car, use a solvent (such as nail polish remover), or perform any of the countless everyday activities that involve complex chemical reactions we're doing chemistry! So why do so many of us desperately resist learning chemistry when we're young?
Now there's a fun, easy way to learn basic chemistry. Whether you're studying chemistry in school and you're looking for a little help making sense of what's being taught in class, or you're just into learning new things, Chemistry For Dummies gets you rolling with all the basics of matter and energy, atoms and molecules, acids and bases, and much more!Tracks a typical chemistry course, giving you step-by-step lessons you can easily grasp Packed with basic chemistry principles and time-saving tips from chemistry professors Real-world examples provide everyday context for complicated topics
Full of modern, relevant examples and updated to mirror current teaching methods and classroom protocols, Chemistry For Dummies puts you on the fast-track to mastering the basics of chemistry.
From the 1930s through the 1970s, chemistry sets were among the most popular Christmas gifts, selling in the millions. But two decades ago, real chemistry sets began to disappear as manufacturers and retailers became concerned about liability. ,em>The Illustrated Guide to Home Chemistry Experiments steps up to the plate with lessons on how to equip your home chemistry lab, master laboratory skills, and work safely in your lab. The bulk of this book consists of 17 hands-on chapters that include multiple laboratory sessions on the following topics:Separating Mixtures Solubility and Solutions Colligative Properties of Solutions Introduction to Chemical Reactions & Stoichiometry Reduction-Oxidation (Redox) Reactions Acid-Base Chemistry Chemical Kinetics Chemical Equilibrium and Le Chatelier's Principle Gas Chemistry Thermochemistry and Calorimetry Electrochemistry Photochemistry Colloids and Suspensions Qualitative Analysis Quantitative Analysis Synthesis of Useful Compounds Forensic Chemistry With plenty of full-color illustrations and photos, Illustrated Guide to Home Chemistry Experiments offers introductory level sessions suitable for a middle school or first-year high school chemistry laboratory course, and more advanced sessions suitable for students who intend to take the College Board Advanced Placement (AP) Chemistry exam. A student who completes all of the laboratories in this book will have done the equivalent of two full years of high school chemistry lab work or a first-year college general chemistry laboratory course.
A Clear, Flexible Approach to Chemistry for the Modern Classroom
Active learning, an increased focus on clinical examples, updates based on current teaching and research findings, and digital innovations designed to engage and personalize readers’ experience make Fundamentals of General, Organic, and Biological Chemistry simply the best choice for readers with a future in allied health. With the Eighth Edition, the authors make learning chemistry a more active experience through features designed to get readers doing chemistry. Every chapter features Hands on Chemistry sections that deepen readers’ understanding of chemistry by having them perform elementary experiments with everyday household items. Group Problemsat the end of every chapter are designed for in-class use and motivate readers to carefully think about higher-level problems, such as how concepts fit together and how to apply these concepts in a clinical application. All of the chapter openers, including many of the Chemistry in Action boxes and end-of-chapter problems, have been rewritten for a stronger clinical focus that provides more relevance to allied health majors.
All content has been updated for the modern classroom with special attention to the biochemistry chapters, making the Eighth Edition of Fundamentals of General, Organic and Biological Chemistry the best choice for future allied health readers. This edition is fully integrated with MasteringChemistry to provide an interactive and engaging experience. Media resources include narrated Video Tutor Solutions for every book chapter that present how to work the most challenging problems and feature additional feedback and instruction from contributor Sara Madsen. NEW in MasteringChemistry is the Chemistry Primer, a diagnostic and remediation tool that provides pre-built assignments designed to get readers up to speed on Chemistry and Math skills at the beginning of the course so they come to class prepared to delve more deeply into topics.
Also available as a Pearson eText or packaged with Mastering Chemistry
Pearson eText is a simple-to-use, mobile-optimized, personalized reading experience that can be adopted on its own as the main course material. It lets students highlight, take notes, and review key vocabulary all in one place, even when offline. Seamlessly integrated videos and other rich media engage students and give them access to the help they need, when they need it. Educators can easily share their own notes with students so they see the connection between their eText and what they learn in class – motivating them to keep reading, and keep learning.
Mastering Chemistry is the leading online homework, tutorial, and assessment system, designed to improve results by engaging students before, during, and after class with powerful content. Instructors ensure students arrive ready to learn by assigning educationally effective content before class, and they encourage critical thinking and retention with in-class resources such as Learning Catalytics™. Students can further master concepts after class through traditional and adaptive homework assignments that provide hints and answer-specific feedback. The Mastering gradebook records scores for all automatically graded assignments in one place, while diagnostic tools give instructors access to rich data to assess student understanding and misconceptions.
Note: You are purchasing a standalone book; Pearson eText and Mastering Chemistry do not come packaged with this content. Students, ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information.
If your instructor has assigned Pearson eText as your main course material, search for:
• 0135213746 / 9780135213742 Pearson eText Fundamentals of General, Organic, and Biological Chemistry, 8/e -- Access Card
• 0135213754 / 9780135213759 Pearson eText Fundamentals of General, Organic, and Biological Chemistry, 8/e -- Instant Access
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0134033094 / 9780134033099 Fundamentals of General, Organic, and Biological Chemistry Plus MasteringChemistry with eText -- Access Card Package
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Chemistry Workbook For Dummies is your ultimate companion for introductory chemistry at the high school or college level. Packed with hundreds of practice problems, this workbook gives you the practice you need to internalize the essential concepts that form the foundations of chemistry. From matter and molecules to moles and measurements, these problems cover the full spectrum of topics you'll see in class—and each section includes key concept review and full explanations for every problem to quickly get you on the right track. This new third edition includes access to an online test bank, where you'll find bonus chapter quizzes to help you test your understanding and pinpoint areas in need of review. Whether you're preparing for an exam or seeking a start-to-finish study aid, this workbook is your ticket to acing basic chemistry.
Chemistry problems can look intimidating; it's a whole new language, with different rules, new symbols, and complex concepts. The good news is that practice makes perfect, and this book provides plenty of it—with easy-to-understand coaching every step of the way.Delve deep into the parts of the periodic table Get comfortable with units, scientific notation, and chemical equations Work with states, phases, energy, and charges Master nomenclature, acids, bases, titrations, redox reactions, and more
Understanding introductory chemistry is critical for your success in all science classes to follow; keeping up with the material now makes life much easier down the education road. Chemistry Workbook For Dummies gives you the practice you need to succeed!
The easy way to take the confusion out of organic chemistry
Organic chemistry has a long-standing reputation as a difficult course. Organic Chemistry I For Dummies takes a simple approach to the topic, allowing you to grasp concepts at your own pace.
This fun, easy-to-understand guide explains the basic principles of organic chemistry in simple terms, providing insight into the language of organic chemists, the major classes of compounds, and top trouble spots. You'll also get the nuts and bolts of tackling organic chemistry problems, from knowing where to start to spotting sneaky tricks that professors like to incorporate.Refreshed example equations New explanations and practical examples that reflect today's teaching methods Fully worked-out organic chemistry problems
Baffled by benzines? Confused by carboxylic acids? Here's the help you need—in plain English!
Accordingly, the book covers not only the 'inorganic' chemistry of the elements, but also analytical, theoretical, industrial, organometallic, bio-inorganic and other cognate areas of chemistry. The authors have broken with recent tradition in the teaching of their subject and adopted a new and highly successful approach based on descriptive chemistry. The chemistry of the elements is still discussed within the context of an underlying theoretical framework, giving cohesion and structure to the text, but at all times the chemical facts are emphasized. Students are invited to enter the exciting world of chemical phenomena with a sound knowledge and understanding of the subject, to approach experimentation with an open mind, and to assess observations reliably. This is a book that students will not only value during their formal education, but will keep and refer to throughout their careers as chemists.Completely revised and updatedUnique approach to the subjectMore comprehensive than competing titles
Organic Synthesis: The Disconnection Approach, 2nd Edition introduces this important technique, to help students to design their own organic syntheses. There are forty chapters: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems.
Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given.
This second edition has been fully revised and updated with a modern look. Recent examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, “Organic Synthesis: Strategy and Control”.
Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry.
Organic Synthesis: The Disconnection Approach, 2nd edition provides a full course in retrosynthetic analysis for chemistry and biochemistry students and a refresher for organic chemists working in industry and academia.
So, you survived the first semester of Organic Chemistry (maybe even by the skin of your teeth) and now it's time to get back to the classroom and lab! Organic Chemistry II For Dummies is an easy-to-understand reference to this often challenging subject.
Thanks to this book, you'll get friendly and comprehensible guidance on everything you can expect to encounter in your Organic Chemistry II course.An extension of the successful Organic Chemistry I For Dummies Covers topics in a straightforward and effective manner Explains concepts and terms in a fast and easy-to-understand way
Whether you're confused by composites, baffled by biomolecules, or anything in between, Organic Chemistry II For Dummies gives you the help you need — in plain English!
The 8th edition of this text maintains its student-friendly writing style wording throughout has been updated for consistency and to be more reflective of modern usage and methods. Chapter 3 on proton NMR spectroscopy has been overhauled and updated. Also, new information on polymers and phosphorus functional groups has been added to Chapter 2 on IR spectroscopy.
What we now call chemistry began in the fiery cauldrons of mystics and sorcerers seeking not to make a better world through science, but rather to make themselves richer through magic formulas and con games. But among these early magicians, frauds, and con artists were a few far-seeing â€œalchemistsâ€ who, through rigorous experimentation, transformed mysticism into science.
By the 18th century the building blocks of nature, the elements of which all matter is composed, were on the verge of being discovery. Initially, it was not easy to determine whether a substance really was an element. Was water just water, plain and simple? Or could it be the sum of other (unknown and maybe unknowable) parts? And if water was made up of other substances, how could it be broken down into discreet, fundamental, and measurable components?
Scientific historians generally credit the great 18th century French chemist Antoine Lavoisier with addressing these fundamental questions and ultimately modernizing the field of chemistry. Through his meticulous and precise work this chaotic new field of scientific inquiry was given order. Exacting by nature, Lavoisier painstakingly set about performing experiments that would provide lasting and verifiable proofs of various chemical theories. Unfortunately, the outspoken Lavoisier eventually lost his head in the Terror, but others would follow his lead, carefully examining, measuring, and recording their findings.
As the field slowly progressed, another pioneer was to emerged almost 100 years later. Dimitri Mendeleev, an eccentric genius who cut his flowing hair and beard but once a year, sought to answer the most pressing questions that remained to chemists: Why did some elements have properties that resembled those of others? Were there certain natural groups of elements? And, if so, how many, and what elements fit into them? It was Mendeleev who finally addressed all these issues when he constructed the first Periodic Table in the late 1800s.
But between and after Lavoisier and Mendeleev were a host of other colorful, brilliant scientists who made their mark on the field of chemistry. Depicting the lively careers of these scientists and their contributions while carefully deconstructing the history and the science, author Richard Morris skillfully brings it all to life. Hailed by Kirkus Reviews as a â€œclear and lively writer with a penchant for down-to-earth examplesâ€ Morrisâ€™s gift for explanation â€" and pure entertainment â€" is abundantly obvious. Taking a cue from the great chemists themselves, Morris has brewed up a potent combination of the alluringly obscure and the historically momentous, spiked with just the right dose of quirky and ribald detail to deliver a magical brew of history, science, and personalities.
Foster a deeper understanding of theoretical concepts through clear guidance and opportunities for self-assessment throughout; covers the entire Cambridge International AS & A Level Chemistry syllabus (9701).
- Navigate the different routes through the course with ease with clearly divided sections for AS and A Level.
- Focus learning with learning outcomes clearly defined at the beginning of each section
- Test knowledge and understanding with past paper and exam-style questions
- Address the Key Concepts in the syllabus, which are clearly highlighted throughout the course
The Revision and Practice CD included with every Student's Book provides interactive tests, summaries of each topic and advice on examination techniques.
With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development.Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the fieldIncorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development researchAn image bank is available for instructors at www.textbooks.elsevier.com
From formulas and lab techniques to the periodic table, Chemistry for the Utterly Confused focuses on the areas of maximum confusion and breaks down the most difficult chemistry topics into easy-to-understand concepts. This invaluable guide also teaches problem-solving skills you need to master this imposing subject. Whether you're in high school, in college, or simply brushing up on chemistry knowledge, this fun, easily accessible book will make understanding chemistry a breeze.
Fortunately, there's Schaum's. This all-in-one-package includes more than 650 fully solved problems, examples, and practice exercises to sharpen your problem-solving skills. Plus, you will have access to 16 detailed videos featuring Chemistry instructors who explain the most commonly tested concepts--it's just like having your own virtual tutor! You'll find everything you need to build confidence, skills, and knowledge for the highest score possible.
More than 40 million students have trusted Schaum's to help them succeed in the classroom and on exams. Schaum's is the key to faster learning and higher grades in every subject. Each Outline presents all the essential course information in an easy-to-follow, topic-by-topic format. You also get hundreds of examples, solved problems, and practice exercises to test your skills.
This Schaum's Outline gives you673 fully solved problems Hundreds of examples with explanations of chemistry concepts Support for all the major textbooks for beginning chemistry courses
Fully compatible with your classroom text, Schaum's highlights all the important facts you need to know. Use Schaum’s to shorten your study time--and get your best test scores!Schaum’s Outlines--Problem Solved.