the drama of the front lines.”
-Richard Danzig, former secretary of the navy
The first major bioterror event in the United States-the anthrax attacks in October 2001-was a clarion call for scientists who work with “hot” agents to find ways of protecting civilian populations against biological weapons. In The Demon in the Freezer, his first nonfiction book since The Hot Zone, a #1 New York Times bestseller, Richard Preston takes us into the heart of Usamriid, the United States Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland, once the headquarters of the U.S. biological weapons program and now the epicenter of national biodefense.
Peter Jahrling, the top scientist at Usamriid, a wry virologist who cut his teeth on Ebola, one of the world’s most lethal emerging viruses, has ORCON security clearance that gives him access to top secret information on bioweapons. His most urgent priority is to develop a drug that will take on smallpox-and win. Eradicated from the planet in 1979 in one of the great triumphs of modern science, the smallpox virus now resides, officially, in only two high-security freezers-at the Centers for Disease Control in Atlanta and in Siberia, at a Russian virology institute called Vector. But the demon in the freezer has been set loose. It is almost certain that illegal stocks are in the possession of hostile states, including Iraq and North Korea. Jahrling is haunted by the thought that biologists in secret labs are using genetic engineering to create a new superpox virus, a smallpox resistant to all vaccines.
Usamriid went into a state of Delta Alert on September 11 and activated its emergency response teams when the first anthrax letters were opened in New York and Washington, D.C. Preston reports, in unprecedented detail, on the government’s response to the attacks and takes us into the ongoing FBI investigation. His story is based on interviews with top-level FBI agents and with Dr. Steven Hatfill.
Jahrling is leading a team of scientists doing controversial experiments with live smallpox virus at CDC. Preston takes us into the lab where Jahrling is reawakening smallpox and explains, with cool and devastating precision, what may be at stake if his last bold experiment fails.
See core concepts applied to real-life situations with clinical vignettes throughout the text.Discover the newest in physiology with updates that reflect the latest advances in molecular biology, cardiovascular, neurophysiology and gastrointestinal topics.
Visualize physiologic principles clearly with over 1000 bold, full-color drawings and diagrams.
Distinguish core concepts from more in-depth material with a layout that uses gray shading to clearly differentiate between "need-to-know" and "nice-to-know" information.
Testosterone is the most crucial hormone in the male body--and every man's T levels begin a slow, steady decline as he ages. The result? Loss of strength and muscle mass. Poor sugar metabolism. Increased body fat, especially around the waist. Loss of T also affects red blood cell production, vitality, bone density, mental acuity, and sex drive. In short: It slowly chops a man down.
Testosterone Transformation helps a man produce higher levels of T and reverse the downward spiral. By eating the right foods and adopting a new exercise approach, any man at any age can transform his life by starting a positive chain reaction: Raise T levels through the strategies in this book, improve workouts, get stronger, improve workouts even more, get even stronger, and enable the body to use muscle to process sugar--instead of storing it as fat.
Testosterone Transformation is a life-changer: a serious exercise and strategic diet plan that uses the science of a man's own body to help him recharge his sex drive, increase vitality, and reduce health risks across the board.
Why do you fall in love with one person rather than another? In this fascinating and informative book, Helen Fisher, one of the world's leading experts on romantic love, unlocks the hidden code of desire and attachment. Each of us, it turns out, primarily expresses one of four broad personality types—Explorer, Builder, Director, or Negotiator—and each of these types is governed by different chemical systems in the brain. Driven by this biology, we are attracted to partners who both mirror and complement our own personality type.
Until now the search for love has been blind, but Fisher pulls back the curtain and reveals how we unconsciously go about finding the right match. Drawing on her unique study of 40,000 men and women, she explores each personality type in detail and shows you how to identify your own type. Then she explains why some types match up well, whereas others are problematic. (Note to Explorers: be prepared for a wild ride when you hitch your star to a fellow Explorer!) Ultimately, Fisher's investigation into the complex nature of romance and attachment leads to astonishing new insights into the essence of dating, love, and marriage.
Based on entirely new research—including a detailed questionnaire completed by seven million people in thirty-three countries—Why Him? Why Her? will change your understanding of why you love him (or her) and help you use nature's chemistry to find and keep your life partner.
The leading textbook for undergraduate exercise physiology
courses, Physiology of Sport and Exercise, Fifth Edition, is now available
as an enhanced
e-book that includes 18 new full-color animations to supplement the text. The authors, all distinguished researchers and past
presidents of the American College of Sports Medicine, combine their expertise
to deliver superior technical content while maintaining the accessible,
reader-friendly format that has made this textbook a favorite of instructors
and students alike.
The enhanced fifth edition will provide students with an engaging
learning experience. Photos, medical artwork, and illustrations throughout offer
a higher level of detail and clarity to better illustrate how the body performs
and responds to physical activity. These illustrations come to life with 18 full-color
art animations, providing a dynamic new way to experience course material.
The enhanced fifth edition of Physiology of Sport and Exercise also features the updated content
you will find in the print edition, based on the latest research in the field,
including the following:
complete rewrite of the chapters on resistance training, including updated
strength training principles based on the 2009 ACSM position stand and new
sections on core strength, stability training, and high-intensity interval
update and reorganization, based on instructors’ feedback, of the chapters
on metabolism and hormonal control to aid students’ comprehension of these
complex systems New
content on lactic acid as a fuel source, muscle cramps, childhood obesity,
substrate utilization and endocrine response to exercise, and vascular
coverage of central and peripheral cardiac functions, the female athlete
triad, and the menstrual cycleNew
research on effects of physical activity on health, including the addition
of international data on the incidence of cardiovascular disease and
Physiology of Sport and
Exercise, Fifth Edition (Enhanced), stands alone as the best,
most comprehensive resource framing the latest research findings in a
reader-friendly enhanced e-book format. This winning combination makes it
easier—and more engaging—than ever for students to develop their understanding
body’s marvelous abilities to perform various types and intensities of exercise
and sport, to adapt to stressful situations, and to improve its physiological
Common side effects of excessive drinking include poor digestive and liver function; problems with managing blood sugar; weakened circulatory, immune, and nervous systems; and impaired thinking and changes in mood-regulating hormones. While the primary focus of anyone recovering from alcoholism is staying sober, a critical part of recovery involves halting or reversing the physical damage of excessive alcohol consumption. Registered Dietitian Molly Siple’s innovative program helps you improve your health, detoxify, and reduce the risk of degenerative diseases linked to alcohol abuse. Siple’s stress-free, uncomplicated program offers: Critical information on common physical ailments brought on by alcoholismLists of “recovery foods” that help combat specific ills and improve healthManageable recovery goals and easy ways to implement themEasy-to-make recipes for every meal, including snacks and beverages21 days worth of menus to jump-start nutritious eatingShopping lists, recommendations for eating out, and other resourcesEating for Recovery’s guidelines, practical tips, recipes and varied meal plans make it the essential resource for anyone seeking to restore their health and vitality after alcohol abuse.
This high-yield, rapid-fire Q&A book is written by students for students to help first and second year medical students review behavioral science for their course exams as well as prepare for the USMLE Step 1.
About the Book The Deja Review series helps you "Remember what you already know"; the flashcard format helps medical students recall the most important, must-know facts and concepts covered in their course work for behavioral science. This rapid-fire question & answer review book allows students to quickly navigate through the information needed for their course exams and USMLE Step 1. Active recall questions reinforce correct answers to enhance learning - not just passive memorization.
Behavioral Science is often a required course in many medical schools, and Psychiatric conditions are heavily covered on USMLE Step 1. Mnemonics and keywords sprinkled throughout the text facilitate focus on core facts, while clinical vignettes at the end of each chapter allow students to reflect on the topic they have just read. This book will publish with seven other basic science books in the Deja Review series, along with USMLE Step1 and USMLE Step 2 review books for a total of 10 new editions in Fall 2010.
In-Store Date: 7/1/2010
Pub Month: July 2010
FeaturesRapid Recall Q&A format simulates flashcards in a book. Keywords and mnemonics highlighted throughout the text. NEW figures and charts detailing the DSM-IV classifications and criteria NEW chapter on psychopharmacology Updated chapter on Health care in the United States Expanded chapters on Epidemiology and Biostatistics Clinical vignette review questions at the end of each chapter. Written by med student who aced the USMLE. Two column format allows for “flashcard” use of Q&A USMLE-format vignettes at the end of each chapter provide review of material covered in a clinical presentation. Clinical correlations of basic science throughout the text help students prepare for course work and board exams. Content complements other review material and works in conjunction with other larger course books. Portable size for use on the go Chapters written by med students ensures the most up-to-date coverage of content actually covered on course exam and USMLE
Market / Audience
Primary Market: First and second year US and Canadian medical students preparing for USMLE Step 1: 17,000
Secondary Market: International MD USMLE Step 1 test-takers: 16,000
DO Students USMLE Step 1 test-takers: 1,500
About the Authors
Gene Ryan Quinn, MD (Seattle, WA) is a fourth year medical student from the University of Washington School of Medicine. He graduated from Tulane University with an MS in Cell and Molecular Biology and holds a BA in Psychology from University of Washington, Seattle. He was formerly a Pediatric Mental Health Specialist at Children's Hospital in Seattle.
"This behavioral science review book is well organized, quite thorough, and easy to use. It offers a fairly comprehensive review of behavioral science topics that might be tested on the USMLE Step 1. Medical students studying for this exam will find this book a valuable study guide for this subject. Weighted Numerical Score: 90 - 4 Stars!" -- Doody’s Book Review Service
David Kessler didn't care about all that. In this book he tells for the first time the thrilling detective story of how the underdog FDA—while safeguarding the nation's food, drugs, and blood supply—finally decided to take on one of the world's most powerful opponents, and how it won. Like A Civil Action or And the Band Played On, A Question of Intent weaves together science, law, and fascinating characters to tell an important and often unexpectedly moving story. We follow Kessler's team of investigators as they race to find the clues that will allow the FDA to assert jurisdiction over cigarettes, while the tobacco companies and their lawyers fight back—hard. Full of insider information and drama, told with wit, and animated by its author's moral passion, A Question of Intent reads like a Grisham thriller, with one exception—everything in it is true.
Great Results Begin with Great Questions
In this new expanded edition of her classic international bestseller, Marilee Adams shows how the kinds of questions we ask shape our thinking and can be the root cause of many personal and organizational problems. She uses a highly instructive and entertaining story to show how to quickly recognize any undermining questions that pop into your mind—or out of your mouth—and reframe them to achieve amazingly positive and practical results. The third edition includes a new introduction and epilogue and two powerful new tools that show how Question Thinking can dramatically improve coaching and leadership. Based on Adams's decades of research and experience, this book can make a life-transforming difference—as it already has for many thousands of people around the world.
Millions of women struggle every day with problems like low energy, unexplained weight gain, and dull moods, yet too often diet, exercise, and pharmaceutical drugs are thought to be the only available options. Hormones—the chemical messengers of the body—influence every single process in our bodies: they govern our growth, weight, and energy, as well as fight stress and anxiety, relieve depression, and maintain personal drive.
Based on Dr. Kristy Vermeulen’s popular six-week online course, Happy Hormones explains how hormones affect your day-to-day routine and provides expert guidance to help you identify your hormonal imbalances and treat them in a natural, healthy way.
Happy Hormones also includes:
• Simple and effective self-assessments to help you diagnose your hormonal imbalances
• Six-step hormonal balancing programs for adrenal, thyroid, progesterone, estrogen, and testosterone imbalances
• Tools to help you read your own hormonal messages so you can stay in tune with your body and improve your overall well-being
• FAQs of bioidentical and synthetic hormones, along with guidelines to help you safely and effectively apply them in your treatment program
• Nutrition program with over 45 delicious, healthy, and hormone-friendly recipes
• Expert guidance to feeling and looking young, healthy, and fabulous
Happy Hormones is a comprehensive, practical guide for any woman interested in balancing their hormones. It will help you get back to your energetic, vibrant, and healthy self. Representing an important application of a fast-growing branch of health science, Happy Hormones will allow you to shed unwanted weight and regain your energy for a healthy, fabulous life.
Carry the same authoritative, useful knowledge that readers of Guyton have come to trust – right in your pocket.
Easily locate more in-depth discussions inside the parent text with abundant cross-references and a parallel chapter organization.
Quickly access all of the most current physiology information on the go.
Written in a clear, concise, logical style, this trusted text reviews the fundamental principles of the structure, function and pathologies of the human kidney that are essential for an understanding of clinical medicine. Combining the latest research with a fully integrated teaching approach, the eighth edition of Vander's Renal Physiology features revised sections that explain how the kidneys affect other body systems and how they in turn are affected by these systems. Each chapter is filled with the tools you need to truly learn key concepts rather than merely memorize facts.
Features:Begins with the basics and works up to advanced principles Focuses on the logic of renal processes Includes the most current research on the molecular and genetic principles underlying renal physiology Explains the relationship between blood pressure and renal function Presents the normal functions of the kidney with clinical correlations to disease states Includes study questions with an answer key at the end of each chapter Features learning aids such as flow charts, diagrams, key concept clinical examples, boxed statements to emphasize major points, learning objectives, and review questions with answers and explanations
Gain a quick and easy understanding of the physiology of kidney and renal function
Drawing extensively on interviews with adults with intersex conditions, parents, and physicians, Karkazis moves beyond the heated rhetoric to reveal the complex reality of how intersexuality is understood, treated, and experienced today. As she unravels the historical, technological, social, and political forces that have culminated in debates surrounding intersexuality, Karkazis exposes the contentious disagreements among theorists, physicians, intersex adults, activists, and parents—and all that those debates imply about gender and the changing landscape of intersex management. She argues that by viewing intersexuality exclusively through a narrow medical lens we avoid much more difficult questions. Do gender atypical bodies require treatment? Should physicians intervene to control the “sex” of the body? As this illuminating book reveals, debates over treatment for intersexuality force reassessment of the seemingly natural connections between gender, biology, and the body.
Drawing on physics and mechanical engineering, Steven Vogel looks at how animals swim and fly, modes of terrestrial locomotion, organism responses to winds and water currents, circulatory and suspension-feeding systems, and the relationship between size and mechanical design. He also investigates links between the properties of biological materials--such as spider silk, jellyfish jelly, and muscle--and their structural and functional roles. Early chapters and appendices introduce relevant physical variables for quantification, and problem sets are provided at the end of each chapter. Comparative Biomechanics is useful for physical scientists and engineers seeking a guide to state-of-the-art biomechanics. For a wider audience, the textbook establishes the basic biological context for applied areas--including ergonomics, orthopedics, mechanical prosthetics, kinesiology, sports medicine, and biomimetics--and provides materials for exhibit designers at science museums.Problem sets at the ends of chapters Appendices cover basic background information Updated and expanded documentation and materials Revised figures and text Increased coverage of friction, viscoelastic materials, surface tension, diverse modes of locomotion, and biomimetics
Pairing weights with the BOSU(R) Balance Trainer's unique unstable platform is the ideal way to get in shape, burn fat and develop powerful, lean muscles. The lifting builds and sculpts primary muscles, while the balancing tones secondary and supporting muscles for maximum results. This book's unique program draws on the unbeatable combination to super-charge your workout with highly effective exercises:
- FLYS while lying on the dome to target your chest and shred your core
- CURLS while balancing on the flat side to build biceps and tone your legs
- Deep-knee SQUATS with an overhead bpress to work every muscle group
Packed with dozens of fully illustrated, easy-to-follow exercises, as well as day-by-day workout programs for beginners, weekend warriors and elite athletes, Weights on the BOSU(R) Balance Trainer is the ultimate guide to quickly transforming your body.
In this penetrating analysis of gender, Paul B. Preciado shows the ways in which the synthesis of hormones since the 1950s has fundamentally changed how gender and sexual identity are formulated, and how the pharmaceutical and pornography industries are in the business of creating desire. This riveting continuation of Michel Foucault's The History of Sexuality also includes Preciado's diaristic account of his own use of testosterone every day for one year, and its mesmerizing impact on his body as well as his imagination.
Provides a rich understanding of the body's dynamic processes through key experimental observations and examples.
Includes Student Consult access to the complete and searchable contents of the book online, as well as relevant bonus content from other Student Consult titles, an image gallery, 10 physiology animations, and much more.Features updated coverage throughout to expand your understanding of the most current trends in physiology and medicine, including the latest cellular and molecular knowledge.
Includes shaded boxes that highlight and explain important clinical and molecular information.
Presents new section editors who ensure that you are getting the freshest, most clinically relevant information available today.
Summarizes need-to-know information in each chapter with Key Points sections.
270+ full-color photographs and illustrations!
A Doody's Core Title for 2011!
4 STAR DOODY'S REVIEW!
"This is an excellent overview of the basic physiology and clinical aspects of endocrinology for trainees. The size of the book and the well-written text, supported by visual aids, make this a convenient book to read and develop a beginning foundation in endocrinology."--Doody's Review Service
Greenspan’s Basic & Clinical Endocrinology, 9e delivers a succinct, leading-edge overview of the underlying molecular biology of the endocrine system and the latest perspectives on the diagnosis and treatment of specific diseases and disorders. Featuring an enhanced design that includes hundreds of full-color illustrations and clinical photographs, Greenspan’s is a true must-have during traditional or integrated courses in endocrinology, endocrinology rotation, or for exam prep in internal medicine and endocrinology.
Greenspan’s provides clinically relevant coverage of metabolic bone disease, pancreatic hormones and diabetes mellitus, hypoglycemia, obesity, geriatric endocrinology, and many other diseases and disorders. Supporting this essential material is a handy appendix of normal hormone reference ranges.
The book is divided into two parts. The first provides a clear and detailed introduction to the structure and function of the human musculoskeletal system and its structural adaptations, essential for a thorough understanding of human movement. The second part focuses on the biomechanics of movement, describing the forces that act on the human body and the effects of those forces on the movement of the body.
Every chapter includes numerous applied examples from sport and exercise, helping the student to understand how mechanical concepts describe both simple and complex movements, from running and jumping to pole-vaulting or kicking a football. In addition, innovative worksheets for field and laboratory work are included that contain clear objectives, a description of method, data recording sheets, plus a set of exemplary data and worked analysis. Alongside these useful features are definitions of key terms plus review questions to aid student learning, with detailed solutions provided for all numerical questions.
No other textbook offers such a clear, easy-to-understand introduction to the fundamentals of biomechanics. This is an essential textbook for any biomechanics course taken as part of degree programme in sport and exercise science, kinesiology, physical therapy, sports coaching or athletic training.
The teaching style and presentation has been strengthened throughout, and includes learning objectives and “recap” links at the beginning of each chapter that remind the reader of key findings and principles, while cross-referencing makes it easy to locate related information quickly and efficiently. There are also more case studies, with detailed answers applying theory to practice.
Essential Endocrinology and Diabetes is the perfect resource for a course on endocrinology and diabetes, as part of USMLE teaching, and an on-going companion during postgraduate clinical and scientific study. It is accompanied by a FREE enhanced Wiley Desktop Edition - the interactive, digital version of the book - featuring downloadable text and images, highlighting and note taking facilities, book-marking, cross-referencing, in-text searching, and linking to references and glossary terms.
For those involved in the identification and management of patients with inborn errors of metabolism, this book is now recognised as the standard textbook in this interdisciplinary field. It has proved to be indispensable for professionals in specialities ranging from pediatrics, neonatology, pathological biochemistry and genetics to neurology, internal medicine, nursing, dietetics and psychology. This 5th edition has been extensively revised and updated.
What ́s new
- Additional chapter focusing on inborn errors affecting adults, particularly the late neurological presentations
- Numerous updates on diagnostic procedures and treatment
- Newly discovered disorders.
As with previous editions, the book opens with a section presenting the clinical approach to inborn metabolic diseases for those cases in which a diagnosis is being sought. This now includes a chapter on the clinical presentation of metabolic diseases in the older age range, using an analogous structure. If a particular diagnosis is already suspected, the reader may refer to the following sections of the book containing general chapters on diagnostic procedures and treatment, and on specific groups of disorders. As with earlier editions, the chapters have been written by authors who are internationally recognised experts on their subjects. They provide information in a clear, relevant and concise manner using a coherent structure.
Metabolism is a complicated subject involving complex molecules and interrelated pathways. These metabolic pathways are usually taught separately with the result that the student develops a detailed but compartmentalised approach to metabolism and frequently fails to see the overall picture and its physiological significance.
Using the at a Glance format, the book takes the student through a complete course in intermediary metabolism in an integrated manner. The same chart is repeated throughout the book with the individual pathway under study highlighted.
The book is an ideal text for introductory biochemistry courses and has established itself as an enormously popular book amongst lecturers and students alike. This third edition is fully updated and includes five new chapters to mirror those topics currently taught at undergraduate level:
1. Metabolic Channelling
2. Glucose homeostasis and Reye's Disease
3. Pentose phosphate pathway and the prodcution of NADPH
4. Tryptophan metabolism in health and disease
5. Tyrosine metabolism in health and disease
This collection of little-known facts about the human body answers the questions you have always wanted to ask but never dared to, such as:• Can smoking make your teeth fall out?
• Is it safe to eat moldy food after the mold’s been cut off?
• Do intelligent people have bigger brains?
• How do astronauts poo in space?
The book also offers many unbelievable-but-true historical factoids about the body. For example:
• Have you ever heard of Dr. Strangelove Syndrome? It’s a rare condition caused by damage to certain parts in the brain, which results in a person’s hand acting independently and taking on a life of its own.
• Did you know that there is also a rare condition called Foreign Accent Syndrome, which results in people suddenly developing a foreign accent?
• Have you ever wondered if a heart transplant could change your personality? The short answer is, yes!
• Did you know that men used hair gel 2000 years ago during the Iron Age?
Why You Shouldn't Eat Your Boogers offers of cornucopia of body trivia that will have readers cringing with delight! You can read it on the subway, in the bathroom, or even in a heavy downpour! For contrary to popular belief, according to this book, you cannot catch cold by standing in the rain!
Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.
Access comprehensive, continually updated research on the physiology of organ systems and clinical topics in the pharmacology of anesthetic drugs.
Quickly and easily reference the information you need through user-friendly tables, figures, and algorithms, all presented in lavish full color throughout.
Understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these key areas.
In the end, it’s how long that happiness is able to last that matters the most. Of course you would want your happiness to last for as long as you live, but the fact that you want to read this book means that you probably don’t know what happiness is or how to obtain it.
The truth is that happiness is not as difficult to achieve as you think it would be and this book would explain why.
Illustrated by more than 1000 clear line diagrams
Complemented with numerous tables and flowcharts for quick comprehension
Text and figures in an attractive four colour format
A balanced amalgamation of pure and applied text
Highlights applied aspects of physiology in separate boxes
Systematic organization of text to facilitate easy review
Hormones. Growth spurts. Mood swings. All combined with blood sugars..
The teen years with diabetes on board are a challenging time for parents and anyone who cares about a child with diabetes. Raising Teens with Diabetes: A Survival Guide for Parents, by well-known diabetes mom, author, and advocate Moira McCarthy, is a no-nonsense, honest approach at not just surviving but thriving in those years, from a mom who has been there..
Raising Teens with Diabetes is a must-have resource for anyone navigating the waters of parenting a child with diabetes.
Written by diabetes expert Dr David Cavan and in association with diabetes.co.uk, the UK's largest online diabetes community, Reverse Your Diabetes also tackles the myths and misinformation about type 2 diabetes. This is an essential book that will empower you to take control of your diabetes and maximise your health for good.
“Love your explanations! It demystifies all things cardiac in a way that helps explain it to patients.” Reader Experience of www.thepad.pm
Dr. Otis Brawley is the chief medical and scientific officer of The American Cancer Society, an oncologist with a dazzling clinical, research, and policy career. How We Do Harm pulls back the curtain on how medicine is really practiced in America. Brawley tells of doctors who select treatment based on payment they will receive, rather than on demonstrated scientific results; hospitals and pharmaceutical companies that seek out patients to treat even if they are not actually ill (but as long as their insurance will pay); a public primed to swallow the latest pill, no matter the cost; and rising healthcare costs for unnecessary—and often unproven—treatments that we all pay for. Brawley calls for rational healthcare, healthcare drawn from results-based, scientifically justifiable treatments, and not just the peddling of hot new drugs.
Brawley's personal history – from a childhood in the gang-ridden streets of black Detroit, to the green hallways of Grady Memorial Hospital, the largest public hospital in the U.S., to the boardrooms of The American Cancer Society—results in a passionate view of medicine and the politics of illness in America - and a deep understanding of healthcare today. How We Do Harm is his well-reasoned manifesto for change.
Beginning with simple theoretical models and experimental techniques, the book develops the complete repertoire of theoretical principles and experimental techniques necessary for understanding and implementing the most sophisticated NMR experiments.
Important new techniques and applications of NMR spectroscopy have emerged since the first edition of this extremely successful book was published in 1996. This updated version includes new sections describing measurement and use of residual dipolar coupling constants for structure determination, TROSY and deuterium labeling for application to large macromolecules, and experimental techniques for characterizing conformational dynamics. In addition, the treatments of instrumentation and signal acquisition, field gradients, multidimensional spectroscopy, and structure calculation are updated and enhanced.
The book is written as a graduate-level textbook and will be of interest to biochemists, chemists, biophysicists, and structural biologists who utilize NMR spectroscopy or wish to understand the latest developments in this field.Provides an understanding of the theoretical principles important for biological NMR spectroscopyDemonstrates how to implement, optimize and troubleshoot modern multi-dimensional NMR experimentsAllows for the capability of designing effective experimental protocols for investigations of protein structures and dynamicsIncludes a comprehensive set of example NMR spectra of ubiquitin provides a reference for validation of experimental methods
The book is divided into four parts. The first chapter in Part I describes the race for stratospheric passenger travel, the story of the Comet 1, and the loss of G-ALYP and G-ALYY, as well as fatigue design and testing today. The second chapter continues with the transatlantic race and the limits of commercial long distance flight, including information on Steve Fossett and the Virgin Atlantic Global Flyer as well as stratospheric balloon flight. Chapter 3 looks at Concorde and the design challenges of high altitude passenger transport, including Space Shuttle maneuvers in the stratosphere. This part ends with an analysis of airspeed margins in stratospheric flight, as well as flight in low density air and jet engine operation, including stalling, at high altitude.
Part II opens with a chapter on the design considerations for emergency descents. Chapter 6 looks at unpressurized flight, as well as gliding, in the stratosphere, while the following chapter considers hypoxia and its effects. The remaining two chapters in this part consider cabin air systems, the cost of air conditioning, ice at high altitude, and the short and long term health effects of stratospheric flight on air- and cabin crew.
The first two chapters in Part III look at outside the airplane: the weather, tropical storms, temperature shears, and clear air turbulence. The environmental impact of stratospheric flight is considered, including the effect on the ozone layer and the use of biofuels at low temperatures. Part IV looks at the way ahead and considers flight in the upper stratosphere, commercial suborbital flights, and unmanned missions to the stratosphere. The book ends with an analysis of the future of stratospheric flight.
This book thus shows that, beyond the solved and unsolved design riddles and forensic engineering efforts to understand flaws, the modern stratospheric airliner is an incomparably complex, wondrous and awe-inspiring engineering achievement.
The clinical chapters are presented in a structured, colour-coded format to allow easy reference. The text also includes highlighted best clinical practice tips. Each chapter is accompanied by high-quality, full-colour photographs that provide excellent examples of the earliest presenting signs as well as illustrating the step-by-step guidance on treatment. This book is an essential manual for every healthcare professional involved in the care of patients with diabetes.
No other skiing book to date has been so well designed, so easy to use, and so committed to weight training. This book enables skiers of all types to increase strength, flexibility, and speed, resulting in higher jumps, quicker runs, and overall success on the slopes. The programs also help raise endurance and helps prevent injuries.
Both beginners and advanced athletes and weight trainers can follow this book and utilize its programs. From recreational to professional, thousands of athletes all over the world are already benefiting from this book and its techniques, and now you can too!
Molecular Nutrition: Nutrition and the Evolution of Humankind:Blends coverage of the molecular mechanisms that underpin nutrient-gene interactions with evolutionary theory Takes a molecular biological approach to problem solving, and moves nutrition away from its dietetic and anthropological origins to the front lines of genomic research Covers key concepts in molecular biology; the –omics revolution and bioinformatics; recent human evolution; molecular mechanisms of gene-nutrient interactions; the importance of nutrients and genomics in disease; the evolution of micronutrient metabolism, protein structure, and human disease; nutrients and the human lifecycle; contemporary dietary patterns; leading-edge laboratory tools in nutrigenomics and human evolutionary studies Written by an internationally recognised expert in the field, Molecular Nutrition: Nutrition and the Evolution of Humankind is an invaluable text and reference book for a wide range of teachers, students, and researchers.