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This third edition is designed to provide a better basis for understanding and using animal models in the current climate of background knowledge and information. It is significantly different than the previous two editions. Chapter 1 is updated from the previous editions addressing general principles of animal selection. It also provides expanded tables of normal physiological values for easy reference. Chapter 2 covers preoperative care, pre-anesthesia, chemical restraint, and includes a significantly expanded section on pain recognition and analgesia particularly in rodents. Chapter 3 provides a summary of normal cardiovascular parameters obtained from intact, awake animals. The data have been rearranged in outline rather than the previous tabular form hopefully resulting in easier reference.
Chapter 4 addresses the techniques, problems and pitfalls of measuring cardiac function in animals. There is an emphasis on the proper use of these measurements to develop new treatment and management strategies as well as using them to study mechanisms of disease. Chapter 5 emphasizes the techniques, problems and pitfalls involved in the measurement of arterial function and ventricular/arterial coupling dynamics. Again the emphasis is on the use of these parameters to develop new treatment and management strategies and for studying the mechanisms of disease. Chapter 6 is a all new chapter dealing specifically with the problems and pitfalls inherent in using isolated heart preparations. The need for this chapter became apparent because so much information was published using obviously non-physiologic preparations. The use of both pumping and non-pumping preparations are described along with techniques necessary for using hearts from larger species where oxygen carrying capacity of the perfusate is critical. The importance of hypoxia and anoxia in the interpretation of results is discussed.
Chapter 7 focuses on the cardiovascular effects of the post-operative analgesic drugs commonly used today and how to avoid potential problems resulting from these effects when reporting experimental data. These data are also presented in outline form rather than the tabular format used in the two previous editions. Chapter 8 addresses the use of naturally occurring animal models of valvular and infectious cardiovascular disease. The information presented has been updated and expanded from the second edition. Chapter 9 examines iatrogenic models of ischemic heart disease.
Chapter 10 is new. It provides a review of iatrogenic, transgenic and naturally occurring animal models of cardiomyopathy and heart failure. Chapter 11 includes new, updated and revised information reviewing iatrogenic and transgenic models of hypertension. Chapter 12 contains new, and updated information on iatrogenic and transgenic models of atherosclerotic disease.
Chapter 13 is completely new material dealing with animal models for the study of neurohumeral and central nervous system control of the cardiovascular system. Chapter 14 is also new. It provides examples of cardiovascular studies involving the use of specific transgenic models not normally associated with the cardiovascular system, such as estrogen receptor knockouts, to study cardiovascular function.
The proceedings contain the “rapporteur talks” which give a broad overview with unique insights by distinguished and renowned scientists. These lectures cover the seven sessions: “History and Reflections”, “Foundations of Quantum Mechanics and Quantum Computation”, “Control of Quantum Systems”, “Quantum Condensed Matter”, “Particles and Fields”, “Quantum Gravity and String Theory” and it ended with a general discussion attempting to arrive at a synthesis.
In the Solvay tradition, the proceedings also include the prepared comments to the rapporteur talks. The discussions among the participants — some of which quite lively and involving dramatically divergent points of view — have been carefully edited and are reproduced in full.Contents:History and Reflections (M Henneaux, J Heilbron and M Gell-Mann)Foundations of Quantum Mechanics and Quantum Computation (A Aspect, A Leggett and J Preskill)Control of Quantum Systems (P Zoller, I Cirac and S Girvin)Quantum Condensed Matter (B Halperin and S Sachdev)Particles and Fields (H Georgi and F Wilczek)Quantum Gravity and String Theory (J Polchinski, J Maldacena and A Guth)General Discussion and Conclusions (D Gross, A Aspect, P Zoller, B Halperin, H Georgi and J Polchinski)
Readership: Graduate students and researchers in physics.
Keywords:Quantum Physics;Solvay ConferenceKey Features:Presents a broad overview of the role of quantum mechanics in contemporary physicsThe rapporteur talks, given by the leaders in the field, provide a beautiful review of the state of the art in each of the subfields discussedThe discussions — transcribed in full — provide a unique view on the thoughts of some of the most outstanding physicistsReviews:
“This book does full justice to the great reputation of the Solvay Conferences. Some of the discussions are on the same topics as in the old days, many are new. It testifies that fundamental physics is still a thriving field of research.”Gerard 't Hooft
“The 25th Solvay Conference had an ambitious theme: The theory of the quantum world, including foundations of quantum physics, cosmology, particle physics, condensed matter physics, quantum control and quantum simulations. It was exciting to see the strong connections between those different areas, and this excitement has been captured in these proceedings. This book documents that 100 years after the first Solvay Conference in Physics, quantum physics still poses puzzles and reveals surprises.”Wolfgang Ketterle
“The 25th Solvay Conference of Physics was an extremely exciting event. It joined the tradition started by the original Solvay meetings at the beginning of the 20th century. A comprehensive overview of the status of Quantum Mechanics and its applications was presented by the world experts and the outstanding problems were discussed deeply. It is clear that this meeting will be as important and as influential as the previous Solvay meetings. The proceedings are an insightful reference about the broad range of topics that were discussed. Just like the previous proceedings, this will also be a document of historic significance.”Nathan Seiberg
“This was one of the most interesting meetings I attended in the last few years. I very much enjoyed being updated on current issues in particle physics, cosmology, and quantum gravity — topics that I wouldn't hear about in conferences that I typically attend. Nearly all talks were presented at an accessible level for the non-specialist, and the extended-discussion format was very informative.”David Wineland
“Highly selected group of physicists, famous or very promising, were invited to assess recent advances and open problems.”RECENSIONI