In The Disappearing Spoon, bestselling author Sam Kean unlocked the mysteries of the periodic table. In THE VIOLINIST'S THUMB, he explores the wonders of the magical building block of life: DNA.
There are genes to explain crazy cat ladies, why other people have no fingerprints, and why some people survive nuclear bombs. Genes illuminate everything from JFK's bronze skin (it wasn't a tan) to Einstein's genius. They prove that Neanderthals and humans bred thousands of years more recently than any of us would feel comfortable thinking. They can even allow some people, because of the exceptional flexibility of their thumbs and fingers, to become truly singular violinists.
Kean's vibrant storytelling once again makes science entertaining, explaining human history and whimsy while showing how DNA will influence our species' future.
FINANCIAL TIMES (LONDON)
World renowned scientist Carl Sagan and acclaimed author Ann Druyan have written a ROOTS for the human species, a lucid and riveting account of how humans got to be the way we are. It shows with humor and drama that many of our key traits--self-awareness, technology, family ties, submission to authority, hatred for those a little different from ourselves, reason, and ethics--are rooted in the deep past, and illuminated by our kinship with other animals. Astonishing in its scope, brilliant in its insights, and an absolutely compelling read, SHADOWS OF FORGOTTEN ANCESTORS is a triumph of popular science.
From the Trade Paperback edition.
Why are rates of conditions like autism, asthma, obesity, and allergies exploding at an unprecedented pace? Why are humans living longer, getting smarter, and having far fewer kids? How might your lifestyle affect your unborn children and grandchildren? How will gene-editing technologies like CRISPR steer the course of human evolution? If Darwin were alive today, how would he explain this new world? Could our progeny eventually become a different species—or several?
In Evolving Ourselves, futurist Juan Enriquez and scientist Steve Gullans conduct a sweeping tour of how humans are changing the course of evolution—sometimes intentionally, sometimes not. For example:
• Globally, rates of obesity in humans nearly doubled between 1980 and 2014. What’s more, there’s evidence that other species, from pasture-fed horses to lab animals to house cats, are also getting fatter.
• As reported by U.S. government agencies, the rate of autism rose by 131 percent from 2001 to 2010, an increase that cannot be attributed simply to increases in diagnosis rates.
• Three hundred years ago, almost no one with a serious nut allergy lived long enough to reproduce. Today, despite an environment in which food allergies have increased by 50 percent in just over a decade, 17 million Americans who suffer from food allergies survive, thrive, and pass their genes and behaviors on to the next generation.
• In the pre-Twinkie era, early humans had quite healthy mouths. As we began cooking, bathing, and using antibiotics, the bacteria in our bodies changed dramatically and became far less diverse. Today the consequences are evident not only in our teeth but throughout our bodies and minds.
Though these harbingers of change are deeply unsettling, the authors argue that we are also in an epoch of tremendous opportunity. New advances in biotechnology help us mitigate the cruel forces of natural selection, from saving prematurely born babies to gene therapies for sickle cell anemia and other conditions. As technology like CRISPR enables us to take control of our genes, we will be able to alter our own species and many others—a good thing, given that our eventual survival will require space travel and colonization, enabled by a fundamental redesign of our bodies.
Future humans could become great caretakers of the planet, as well as a more diverse, more resilient, gentler, and more intelligent species—but only if we make the right choices now.
Intelligent, provocative, and optimistic, Evolving Ourselves is the ultimate guide to the next phase of life on Earth.
From the Hardcover edition.
But what does it mean?
Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life.
Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.
“A smart and important book.”—Gretchen Reynolds, author of The First 20 Minutes
Publications as varied as Wired, Men’s Fitness, and The New Yorker are abuzz over the New York Times bestseller Faster, Higher, Stronger. In it, veteran journalist Mark McClusky explains how today’s top athletes are turning to advanced technology and savvy science to improve their performance. Sports buffs and readers of David Epstein and Gretchen Reynolds will want to join McClusky as he goes behind the scenes everywhere from the Olympics to the NBA Finals, from the World Series to the Tour de France, and from high-tech labs to neighborhood gyms to show how athletes at every level can incorporate cutting-edge science into their own workouts.
From the Trade Paperback edition.
Until recently, we had thought our microbes hardly mattered, but science is revealing a different story, one in which microbes run our bodies and becoming a healthy human is impossible without them.
In this riveting, shocking, and beautifully written book, biologist Alanna Collen draws on the latest scientific research to show how our personal colony of microbes influences our weight, our immune system, our mental health, and even our choice of partner. She argues that so many of our modern diseases—obesity, autism, mental illness, digestive disorders, allergies, autoimmunity afflictions, and even cancer—have their root in our failure to cherish our most fundamental and enduring relationship: that with our personal colony of microbes.
Many of the questions about modern diseases left unanswered by the Human Genome Project are illuminated by this new science. And the good news is that unlike our human cells, we can change our microbes for the better. Collen's book is a revelatory and indispensable guide. It is science writing at its most relevant: life—and your body—will never seem the same again.
Stepping effortlessly from myth to cutting-edge science, Mutants gives a brilliant narrative account of our genetic code and the captivating people whose bodies have revealed it—a French convent girl who found herself changing sex at puberty; children who, echoing Homer’s Cyclops, are born with a single eye in the middle of their foreheads; a village of long-lived Croatian dwarves; one family, whose bodies were entirely covered with hair, was kept at the Burmese royal court for four generations and gave Darwin one of his keenest insights into heredity. This elegant, humane, and engaging book “captures what we know of the development of what makes us human” (Nature).
In 1994 Bryan Sykes was called in as an expert to examine the frozen remains of a man trapped in glacial ice in northern Italy for over 5000 years—the Ice Man. Sykes succeeded in extracting DNA from the Ice Man, but even more important, writes Science News, was his "ability to directly link that DNA to Europeans living today." In this groundbreaking book, Sykes reveals how the identification of a particular strand of DNA that passes unbroken through the maternal line allows scientists to trace our genetic makeup all the way back to prehistoric times—to seven primeval women, the "seven daughters of Eve."
Nessa Carey, a leading epigenetics researcher, connects the field’s arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.
Neanderthal Man tells the story of geneticist Svante Pääbo's mission to answer this question: what can we learn from the genomes of our closest evolutionary relatives? Beginning with the study of DNA in Egyptian mummies in the early 1980s and culminating in the sequencing of the Neanderthal genome in 2010, Neanderthal Man describes the events, intrigues, failures, and triumphs of these scientifically rich years through the lens of the pioneer and inventor of the field of ancient DNA. We learn that Neanderthal genes offer a unique window into the lives of our hominid relatives and may hold the key to unlocking the mystery of why humans survived while Neanderthals went extinct. Pääbo's findings have not only redrawn our family tree, but recast the fundamentals of human history--the biological beginnings of fully modern Homo sapiens, the direct ancestors of all people alive today.
Eight-year-old Corey Haas was nearly blind from a hereditary disorder when his sight was restored through a delicate procedure that made medical history. Like something from a science fiction novel, doctors carefully injected viruses bearing healing genes into the DNA of Corey's eyes—a few days later, Corey could see, his sight restored by gene therapy.
THE FOREVER FIX is the first book to tell the fascinating story of gene therapy: how it works, the science behind it, how patients (mostly children) have been helped and harmed, and how scientists learned from each trial to get one step closer to its immense promise, the promise of a "forever fix," - a cure that, by fixing problems at their genetic root, does not need further surgery or medication.
Told through the voices of the children and families who have been the inspiration, experimental subjects, and successes of genetic science, THE FOREVER FIX is compelling and engaging narrative science that tells explores the future of medicine as well as the families and scientists who are breaking new ground every day.
By identifying the structure of DNA, the molecule of life, Francis Crick and James Watson revolutionized biochemistry and won themselves a Nobel Prize. At the time, Watson was only twenty-four, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science’s greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions, and bitter rivalries.
With humility unspoiled by false modesty, Watson relates his and Crick’s desperate efforts to beat Linus Pauling to the Holy Grail of life sciences, the identification of the basic building block of life. Never has a scientist been so truthful in capturing in words the flavor of his work.
The common ancestry of all humanity
The role of genes in sickness and health
Debates over the use of genetic technology
Written in an engaging, narrative manner, this concise introduction is an ideal starting point for anyone who wants to know more about genes, DNA, and the genetic ties that bind us all.
The most disruptive force on the planet resides in DNA. Biotech companies and academic researchers are just beginning to unlock the potential of piecing together life from scratch. Champions of synthetic biology believe that turning genetic code into Lego-like blocks to build never-before-seen organisms could solve the thorniest challenges in medicine, energy, and environmental protection. But as the hackers who cracked open the potential of the personal computer and the Internet proved, the most revolutionary discoveries often emerge from out-of-the-way places, forged by brilliant outsiders with few resources besides boundless energy and great ideas.
In Biopunk, Marcus Wohlsen chronicles a growing community of DIY scientists working outside the walls of corporations and universities who are committed to democratizing DNA the way the Internet did information. The "biohacking" movement, now in its early, heady days, aims to unleash an outbreak of genetically modified innovation by making the tools and techniques of biotechnology accessible to everyone. Borrowing their idealism from the worlds of open-source software, artisinal food, Internet startups, and the Peace Corps, biopunks are devoted advocates for open-sourcing the basic code of life. They believe in the power of individuals with access to DNA to solve the world's biggest problems.
You'll meet a new breed of hackers who aren't afraid to get their hands wet, from entrepreneurs who aim to bring DNA-based medical tools to the poorest of the poor to a curious tinkerer who believes a tub of yogurt and a jellyfish gene could protect the world's food supply. These biohackers include:
-A duo who started a cancer drug company in their kitchen
-A team who built an open-source DNA copy machine
-A woman who developed a genetic test in her apartment for a deadly disease that had stricken her family
Along with the potential of citizen science to bring about disruptive change, Wohlsen explores the risks of DIY bioterrorism, the possibility of genetic engineering experiments gone awry, and whether the ability to design life from scratch on a laptop might come sooner than we think.
Conventional wisdom dictates that our genetic destiny is fixed at conception. But Dr. Moalem's groundbreaking book shows us that the human genome is far more fluid and fascinating than your ninth grade biology teacher ever imagined. By bringing us to the bedside of his unique and complex patients, he masterfully demonstrates what rare genetic conditions can teach us all about our own health and well-being.
In the brave new world we're rapidly rocketing into, genetic knowledge has become absolutely crucial. INHERITANCE provides an indispensable roadmap for this journey by teaching you:
-Why you may have recovered from the psychological trauma caused by childhood bullying-but your genes may remain scarred for life.
-How fructose is the sugar that makes fruits sweet-but if you have certain genes, consuming it can buy you a one-way trip to the coroner's office.
-Why ingesting common painkillers is like dosing yourself repeatedly with morphine-if you have a certain set of genes.
-How insurance companies legally use your genetic data to predict the risk of disability for you and your children-and how that impacts the coverage decisions they make for your family.
-How to have the single most important conversation with your doctor-one that can save your life.
-Why people with rare genetic conditions hold the keys to medical problems affecting millions.
In this trailblazing book, Dr. Moalem employs his wide-ranging and entertaining interdisciplinary approach to science and medicine-- explaining how art, history, superheroes, sex workers, and sports stars all help us understand the impact of our lives on our genes, and our genes on our lives. INHERITANCE will profoundly alter how you view your genes, your health--and your life.
Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it.
The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.
On May 20, 2010, headlines around the world announced one of the most extraordinary accomplishments in modern science: the creation of the world’s first synthetic lifeform. In Life at the Speed of Light, scientist J. Craig Venter, best known for sequencing the human genome, shares the dramatic account of how he led a team of researchers in this pioneering effort in synthetic genomics—and how that work will have a profound impact on our existence in the years to come. This is a fascinating and authoritative study that provides readers an opportunity to ponder afresh the age-old question “What is life?” at the dawn of a new era of biological engineering.
In Regenesis, Harvard biologist George Church and science writer Ed Regis explore the possibilities—and perils—of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies—far from the out-of-control nightmare depicted in science fiction—have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.
Brenda Maddox tells a powerful story of a remarkably single-minded, forthright, and tempestuous young woman who, at the age of fifteen, decided she was going to be a scientist, but who was airbrushed out of the greatest scientific discovery of the twentieth century.
Updated 2017 Edition! For the fifth anniversary of one of the biggest discoveries in physics, we’ve updated this eBook to include our continuing analysis of the discovery, of the questions it answers and those it raises. As the old adage goes, where there’s smoke, there’s fire. Where there is effect, there must be cause. The planet Neptune was found in 1846 because the mathematics of Newton's laws, when applied to the orbit of Uranus, said some massive body had to be there. Astronomers eventually found it, using the best telescopes available to peer into the sky. This same logic is applied to the search for the Higgs boson. One consequence of the prevailing theory of physics, called the Standard Model, is that there has to be some field that gives particles their particular masses. With that there has to be a corresponding particle, made by creating waves in the field, and this is the Higgs boson, the so-called God particle. This eBook chronicles the search – and demonstrates the power of a good theory. Based on the Standard Model, physicists believed something had to be there, but it wasn't until the Large Hadron Collider was built that anyone could see evidence of the Higgs – and finally in July 2012, they did. A Higgs-like particle was found near the energies scientists expected to find it. Now, armed with better evidence and better questions, the scientific process continues. This eBook gathers the best reporting and analysis from Scientific American to explain that process – the theories, the search, the ongoing questions. In essence, everything you need to know to separate Higgs from hype.
Fewer ideas have been more toxic or harmful than the idea of the biological reality of race, and with it the idea that humans of different races are biologically different from one another. For this understandable reason, the idea has been banished from polite academic conversation. Arguing that race is more than just a social construct can get a scholar run out of town, or at least off campus, on a rail. Human evolution, the consensus view insists, ended in prehistory.
Inconveniently, as Nicholas Wade argues in A Troublesome Inheritance, the consensus view cannot be right. And in fact, we know that populations have changed in the past few thousand years—to be lactose tolerant, for example, and to survive at high altitudes. Race is not a bright-line distinction; by definition it means that the more human populations are kept apart, the more they evolve their own distinct traits under the selective pressure known as Darwinian evolution. For many thousands of years, most human populations stayed where they were and grew distinct, not just in outward appearance but in deeper senses as well.
Wade, the longtime journalist covering genetic advances for The New York Times, draws widely on the work of scientists who have made crucial breakthroughs in establishing the reality of recent human evolution. The most provocative claims in this book involve the genetic basis of human social habits. What we might call middle-class social traits—thrift, docility, nonviolence—have been slowly but surely inculcated genetically within agrarian societies, Wade argues. These “values” obviously had a strong cultural component, but Wade points to evidence that agrarian societies evolved away from hunter-gatherer societies in some crucial respects. Also controversial are his findings regarding the genetic basis of traits we associate with intelligence, such as literacy and numeracy, in certain ethnic populations, including the Chinese and Ashkenazi Jews.
Wade believes deeply in the fundamental equality of all human peoples. He also believes that science is best served by pursuing the truth without fear, and if his mission to arrive at a coherent summa of what the new genetic science does and does not tell us about race and human history leads straight into a minefield, then so be it. This will not be the last word on the subject, but it will begin a powerful and overdue conversation.
From the Trade Paperback edition.
Darwin’s theory of natural selection explains how useful adaptations are preserved over time. But the biggest mystery about evolution eluded him. As genetics pioneer Hugo de Vries put it, “natural selection may explain the survival of the fittest, but it cannot explain the arrival of the fittest.”
Can random mutations over a mere 3.8 billion years really be responsible for wings, eyeballs, knees, camouflage, lactose digestion, photosynthesis, and the rest of nature’s creative marvels? And if the answer is no, what is the mechanism that explains evolution’s speed and efficiency?
In Arrival of the Fittest, renowned evolutionary biologist Andreas Wagner draws on over fifteen years of research to present the missing piece in Darwin's theory. Using experimental and computational technologies that were heretofore unimagined, he has found that adaptations are not just driven by chance, but by a set of laws that allow nature to discover new molecules and mechanisms in a fraction of the time that random variation would take.
Consider the Arctic cod, a fish that lives and thrives within six degrees of the North Pole, in waters that regularly fall below 0 degrees. At that temperature, the internal fluids of most organisms turn into ice crystals. And yet, the arctic cod survives by producing proteins that lower the freezing temperature of its body fluids, much like antifreeze does for a car’s engine coolant. The invention of those proteins is an archetypal example of nature’s enormous powers of creativity.
Meticulously researched, carefully argued, evocatively written, and full of fascinating examples from the animal kingdom, Arrival of the Fittest offers up the final puzzle piece in the mystery of life’s rich diversity.
Examining the hidden secrets of human evolution in our genetic code, Spencer Wells reveals how developments in the revolutionary science of population genetics have made it possible to create a family tree for the whole of humanity. Replete with marvelous anecdotes and remarkable information, from the truth about the real Adam and Eve to the way differing racial types emerged, The Journey of Man is an enthralling, epic tour through the history and development of early humankind.
Fields and Johnston tell real life stories that hinge on the inheritance of one tiny change rather than another in an individual's DNA: a mother wrongly accused of poisoning her young son when the true killer was a genetic disorder; the screen siren who could no longer remember her lines because of Alzheimer's disease; and the president who was treated with rat poison to prevent another heart attack. In an engaging and accessible style, Fields and Johnston explain what our personal DNA code is, how a few differences in its long list of DNA letters makes each of us unique, and how that code influences our appearance, our behavior, and our risk for such common diseases as diabetes or cancer.
The book covers topics from introductory level right up to cutting edge research. High-profile cases are addressed throughout the text, near the sections dealing with the science or issues behind these cases. Ten new chapters have been added to accommodate the explosion of new information since the turn of the century. These additional chapters cover statistical genetic analysis of DNA data, an emerging field of interest to DNA research. Several chapters on statistical analysis of short tandem repeat (STR) typing data have been contributed by Dr. George Carmody, a well-respected professor in forensic genetics. Specific examples make the concepts of population genetics more understandable.
This book will be of interest to researchers and practitioners in forensic DNA analysis, forensic scientists, population geneticists, military and private and public forensic laboratories (for identifying individuals through remains), and students of forensic science.*The only book available that specifically covers detailed information on mitochondrial DNA and the Y chromosome
*Chapters cover the topic from introductory level right up to "cutting edge" research
*High-profile cases are addressed throughout the book, near the sections dealing with the science or issues behind these cases
*NEW TO THIS EDITION: D.N.A. Boxes--boxed "Data, Notes & Applications" sections throughout the book offer higher levels of detail on specific questions
Using DNA collected from remains as a genetic blueprint, scientists aim to engineer extinct traits--traits that evolved by natural selection over thousands of years--into living organisms. But rather than viewing de-extinction as a way to restore one particular species, Shapiro argues that the overarching goal should be the revitalization and stabilization of contemporary ecosystems. For example, elephants with genes modified to express mammoth traits could expand into the Arctic, re-establishing lost productivity to the tundra ecosystem.
Looking at the very real and compelling science behind an idea once seen as science fiction, How to Clone a Mammoth demonstrates how de-extinction will redefine conservation's future.
Scientists have long believed that the “great leap forward” that occurred some 40,000 to 50,000 years ago in Europe marked end of significant biological evolution in humans. In this stunningly original account of our evolutionary history, top scholars Gregory Cochran and Henry Harpending reject this conventional wisdom and reveal that the human species has undergone a storm of genetic change much more recently. Human evolution in fact accelerated after civilization arose, they contend, and these ongoing changes have played a pivotal role in human history. They argue that biology explains the expansion of the Indo-Europeans, the European conquest of the Americas, and European Jews' rise to intellectual prominence. In each of these cases, the key was recent genetic change: adult milk tolerance in the early Indo-Europeans that allowed for a new way of life, increased disease resistance among the Europeans settling America, and new versions of neurological genes among European Jews.
Ranging across subjects as diverse as human domestication, Neanderthal hybridization, and IQ tests, Cochran and Harpending's analysis demonstrates convincingly that human genetics have changed and can continue to change much more rapidly than scientists have previously believed. A provocative and fascinating new look at human evolution that turns conventional wisdom on its head, The 10,000 Year Explosion reveals the ongoing interplay between culture and biology in the making of the human race.
With The Longevity Seekers, science writer Ted Anton takes readers inside this tale that began with worms and branched out to snare innovative minds from California to Crete, investments from big biotech, and endorsements from TV personalities like Oprah and Dr. Oz. Some of the research was remarkable, such as the discovery of an enzyme in humans that stops cells from aging. And some, like an oft-cited study touting the compound resveratrol, found in red wine—proved highly controversial, igniting a science war over truth, credit, and potential profit. As the pace of discovery accelerated, so too did powerful personal rivalries and public fascination, driven by the hope that a longer, healthier life was right around the corner. Anton has spent years interviewing and working with the scientists at the frontier of longevity science, and this book offers a behind-the-scenes look at the state-of-the-art research and the impact it might have on global public health, society, and even our friends and family.
With spectacular science and an unforgettable cast of characters, The Longevity Seekers has all the elements of a great story and sheds light on discoveriesthat could fundamentally reshape human life.
Full, 4-color illustration program enhances and reinforces key concepts and themes
Uniform organization of chapters includes interest boxes that focus on human health and disease, chapter-opening case studies, and concept statements to engage non-specialist readers
According to American Demographics, 113 million Americans have begun to trace their roots, making genealogy the second most popular hobby in the country (after gardening). Enthusiasts clamor for new information from dozens of subscription-based websites, email newsletters, and magazines devoted to the subject. For these eager roots-seekers looking to take their searches to the next level, DNA testing is the answer.
After a brief introduction to genealogy and genetics fundamentals, the authors explain the types of available testing, what kind of information the tests can provide, how to interpret the results, and how the tests work (it doesn't involve digging up your dead relatives). It's in expensive, easy to do, and the results are accurate: It's as simple as swabbing the inside of your cheek and popping a sample in the mail.
There are several types of genealogical scenarios you can pursue, such as:Family lore has it that a branch of our family emigrated to Argentina and now I've found some people there with our name. Can testing tell us whether we're from the same family?My mother was adopted and doesn't know her ethnicity. Are there any tests available to help her learn about her heritage?I just discovered someone else with my highly unusual surname. How can we find out if we have a common ancestor?
The authors reveal exactly what is--and what is not--possible with genetic testing. They include case studies of both famous historial mysteries and examples of ordinary folks whose exploration of genetic genealogy has enabled them to trace their roots.
Aging, cancer, stem cells, cloning - the themes of Merchants of Immortality are the stuff of today's headlines, yet they reflect some of humankind's most ancient hopes and fears. Stephen S. Hall delves behind the headlines to reveal just how close scientists are to fulfilling hopes of longer, healthier lives. Merchants of Immortality tackles profound social questions: How close are we to cloning humans? Can stem cell therapies tame illnesses such as heart attacks, Parkinson's disease, and diabetes? How long might our children live?
Hall's account of life-extension research is as dramatic as it is authoritative. The story follows a close-knit but fractious band of scientists and entrepreneurs who work in the shadowy area between profit and the public good. Hall tracks the science of aging back to its father figure, the iconoclastic Leonard Hayflick, who was the first to show that cells age and whose epic legal battles with the federal government cleared the path for today's biotech visionaries. Chief among those is the charismatic Michael West, a former creationist who founded the first biotech company devoted to aging research. West has won both ardent admirers and committed foes in his relentless quest to promote stem cells, therapeutic cloning, and other technologies of "practical immortality." Merchants of Immortality breathes scintillating life into the most momentous science of our day, assesses the political and bioethical controversies it has spawned, and explores its potentially dramatic effect on the length and quality of our lives.
Vegan, low fat, low carb, slow carb: Every diet seems to promise a one-size-fits-all solution to health. But they ignore the diversity of human genes and how they interact with what we eat.
In Food, Genes, and Culture, renowned ethnobotanist Gary Nabhan shows why the perfect diet for one person could be disastrous for another. If your ancestors were herders in Northern Europe, milk might well provide you with important nutrients, whereas if you're Native American, you have a higher likelihood of lactose intolerance. If your roots lie in the Greek islands, the acclaimed Mediterranean diet might save your heart; if not, all that olive oil could just give you stomach cramps.
Nabhan traces food traditions around the world, from Bali to Mexico, uncovering the links between ancestry and individual responses to food. The implications go well beyond personal taste. Today's widespread mismatch between diet and genes is leading to serious health conditions, including a dramatic growth over the last 50 years in auto-immune and inflammatory diseases.
Readers will not only learn why diabetes is running rampant among indigenous peoples and heart disease has risen among those of northern European descent, but may find the path to their own perfect diet.
Maxwell J. Mehlman considers the promises and perils of using genetic engineering in an effort to direct the future course of human evolution. He addresses scientific and ethical issues without choosing sides in the dispute between transhumanists and their challengers. However, Transhumanist Dreams and Dystopian Nightmares reveals that radical forms of genetic engineering could become a reality much sooner than many people think, and that we need to encourage risk-management efforts.
Whether scientists are dubious or optimistic about the prospects for directed evolution, they tend to agree on two things. First, however long it takes to perfect the necessary technology, it is inevitable that humans will attempt to control their evolutionary future, and second, in the process of learning how to direct evolution, we are bound to make mistakes. Our responsibility is to learn how to balance innovation with caution.-- Michael A. Goldman
The first part of the book introduces the essential underpinnings of molecular ecology and gives a review of genetics and discussion of the molecular markers that are most frequently used in ecological research, and a chapter devoted to the newly emerging field of ecological genomics. The second half of the book covers specific applications of molecular ecology, covering phylogeography, behavioural ecology and conservation genetics.
The new edition provides a thoroughly up-to-date introduction to the field, emphasising new types of analyses and including current examples and techniques whilst also retaining the information-rich, highly readable style which set the first edition apart.Incorporates both theoretical and applied perspectives Highly accessible, user-friendly approach and presentation Includes self-assessment activities with hypothetical cases based on actual species and realistic data sets Uses case studies to place the theory in context Provides coverage of population genetics, genomics, phylogeography, behavioural ecology and conservation genetics.
Jennifer Arnold and Bill Klein have inspired millions as stars of TLC’s hit show The Little Couple. Though they both have dwarfism, they have knocked down every obstacle they have encountered together with a positive, can-do attitude. The show has featured the lives of Jennifer (a respected neonatologist) and Bill (a successful entrepreneur) from their marriage in 2009, to the launch of their pet shop, to the adoption of their children, to Jen’s overcoming cancer.
Now, for the first time Jen and Bill are letting readers into their private lives with behind-the-scenes, never-before-told stories about how they fell in love, what inspires them, and the passions that drive their success. They will open up about their struggles with cancer, infertility, adoption, and simply living life in a challenging world.
Jen and Bill have a simple purpose in life: make the world a better place through encouragement and education. A must-have for fans of the show or anyone who has ever faced a difficult obstacle, Life Is Short (No Pun Intended) gives readers a glance at what inspires these positive people to approach life with such optimism and share their lives with the public every day.
Once upon a time you and your partner had a perfect life: dinners out, weekend mornings cuddling in bed, brunch with friends. Then you gave birth to a poop machine (or two). Now, it's all about the pediatrician, breast pumps, princess dresses, and minivans. And discovering that your pride and joy is actually a little A-hole.
When your son wakes you up at 3:00 A.M. because he wants to watch Caillou, he's an a-hole. When your daughter outlines every corner of your living room with a purple crayon, she's an a-hole. When your rug rats purposely paint the kitchen ceiling with their smoothies, they're a-holes. At times like these, it's only natural to want to kill them (or yourself). But it's against the law (and there's the suicide hotline). Plus, there's that whole loving them more than anything in the whole world thing.
In I Heart My Little A-Holes, Karen Alpert shares hilarious stories, lists, and deep thoughts on the joys and horrors of raising children. Accompanied by cheery illustrations and photos I Heart My Little A-Holes will make you laugh so hard you'll wish you were wearing a diaper.
Developed at MIT in collaboration with award-winning high school teachers, BioBuilder teaches the foundational ideas of the emerging synthetic biology field, as well as key aspects of biological engineering that researchers are exploring in labs throughout the world. These lessons will empower teachers and students to explore and be part of solving persistent real-world challenges.Learn the fundamentals of biodesign and DNA engineeringExplore important ethical issues raised by examples of synthetic biologyInvestigate the BioBuilder labs that probe the design-build-test cycleTest synthetic living systems designed and built by engineersMeasure several variants of an enzyme-generating genetic circuitModel "bacterial photography" that changes a strain’s light sensitivityBuild living systems to produce purple or green pigmentOptimize baker’s yeast to produce ?-carotene
Have a New Kid by Friday shows parents how to reverse negative behavior in their children--fast! With his signature wit and encouragement, Dr. Leman offers hope and real, practical, doable strategies for regaining control and becoming the parents they always wanted to be. Focusing on changing a child's attitude, behavior, and character, it contains chapters for each day of the week and a special section with advice on everything from rolling eyes to sibling rivalry to talking back to punching walls and much, much more. This large section of more than 100 specific topics is indexed, allowing parents to flip immediately to any areas of concern for witty, straightforward, and gutsy plans of action.
Internationally acclaimed experts on communication between parents and children, Adele Faber and Elaine Mazlish “are doing for parenting today what Dr. Spock did for our generation” (Parent Magazine). Now, this bestselling classic includes fresh insights and suggestions as well as the author’s time-tested methods to solve common problems and build foundations for lasting relationships, including innovative ways to:
· Cope with your child's negative feelings, such as frustration, anger, and disappointment
· Express your strong feelings without being hurtful
· Engage your child's willing cooperation
· Set firm limits and maintain goodwill
· Use alternatives to punishment that promote self-discipline
· Understand the difference between helpful and unhelpful praise
· Resolve family conflicts peacefully
Enthusiastically praised by parents and professionals around the world, the down-to-earth, respectful approach of Faber and Mazlish makes relationships with children of all ages less stressful and more rewarding.
Based on the latest research on brain development and extensive clinical experience with parents, Dr. Laura Markham’s approach is as simple as it is effective. Her message: Fostering emotional connection with your child creates real and lasting change. When you have that vital connection, you don’t need to threaten, nag, plead, bribe—or even punish.
This remarkable guide will help parents better understand their own emotions—and get them in check—so they can parent with healthy limits, empathy, and clear communication to raise a self-disciplined child. Step-by-step examples give solutions and kid-tested phrasing for parents of toddlers right through the elementary years.
If you’re tired of power struggles, tantrums, and searching for the right “consequence,” look no further. You’re about to discover the practical tools you need to transform your parenting in a positive, proven way.
--Library Journal (starred review)
"A tremendous resource for parents and professionals alike."
--Thomas Atwood, president and CEO, National Council for Adoption
The adoption of a child is always a joyous moment in the life of a family. Some adoptions, though, present unique challenges. Welcoming these children into your family--and addressing their special needs--requires care, consideration, and compassion.
Written by two research psychologists specializing in adoption and attachment, The Connected Child will help you:Build bonds of affection and trust with your adopted child Effectively deal with any learning or behavioral disorders Discipline your child with love without making him or her feel threatened
"A must-read not only for adoptive parents, but for all families striving to correct and connect with their children."
--Carol S. Kranowitz, author of The Out-of-Sync Child
"Drs. Purvis and Cross have thrown a life preserver not only to those just entering uncharted waters, but also to those struggling to stay afloat."
--Kathleen E. Morris, editor of S. I. Focus magazine
"Truly an exceptional, innovative work . . . compassionate, accessible, and founded on a breadth of scientific knowledge and clinical expertise."
--Susan Livingston Smith, program director, Evan B. Donaldson Adoption Institute
"The Connected Child is the literary equivalent of an airline oxygen mask and instructions: place the mask over your own face first, then over the nose of your child. This book first assists the parent, saying, in effect, 'Calm down, you're not the first mom or dad in the world to face this hurdle, breathe deeply, then follow these simple steps.' The sense of not facing these issues alone--the relief that your child's behavior is not off the charts--is hugely comforting. Other children have behaved this way; other parents have responded thusly; welcome to the community of therapeutic and joyful adoptive families."
--Melissa Fay Greene, author of There is No Me Without You: One Woman's Odyssey to Rescue Africa's Children
Each time a new baby arrives, the press from around the world clamors for interviews and information. Visitors are amazed to find seventeen (baby number eighteen is due January 1, 2009) well-groomed, well-behaved, well-schooled children in a home that focuses on family, financial responsibility, fun—and must importantly, faith.
Readers will learn about the Duggars’ marriage—how they communicate effectively, make family decisions, and find quality time alone. They’ll discover how the Duggars manage to educate all their children at home, while providing experiences that go beyond the family walls, through vacations and educational trips. And they’ll see how the Duggar family manages their finances and lives debt-free—even when they built their own 7,000-square-foot house.
Answering the oft asked question—How can I do with one or two children what you do with seventeen(soon to be eighteen)?—Jim Bob and Michelle reveal how they create a warm and welcoming home filled with what Michelle calls “serene chaos.” They show how other parents can succeed whether they’re rearing a single child or several. With spiritual insights, experience-based wisdom, practical tips, and plenty of humorous and tender anecdotes, the Duggars answer the questions that pour into the family’s Web site on a daily basis—especially after every national media interview and TV appearance—including their segments on the Discovery Health Channel’s “Meet the Duggars” series.