Biochemistry

For courses in General, Organic, and Biological Chemistry (2 - Semester)

A Clear, Flexible Approach to Chemistry for the Modern Classroom

Active learning, an increased focus on clinical examples, updates based on current teaching and research findings, and digital innovations designed to engage and personalize readers’ experience make Fundamentals of General, Organic, and Biological Chemistry simply the best choice for readers with a future in allied health. With the Eighth Edition, the authors make learning chemistry a more active experience through features designed to get readers doing chemistry. Every chapter features Hands on Chemistry sections that deepen readers’ understanding of chemistry by having them perform elementary experiments with everyday household items. Group Problemsat the end of every chapter are designed for in-class use and motivate readers to carefully think about higher-level problems, such as how concepts fit together and how to apply these concepts in a clinical application. All of the chapter openers, including many of the Chemistry in Action boxes and end-of-chapter problems, have been rewritten for a stronger clinical focus that provides more relevance to allied health majors.

All content has been updated for the modern classroom with special attention to the biochemistry chapters, making the Eighth Edition of Fundamentals of General, Organic and Biological Chemistry the best choice for future allied health readers. This edition is fully integrated with MasteringChemistry to provide an interactive and engaging experience. Media resources include narrated Video Tutor Solutions for every book chapter that present how to work the most challenging problems and feature additional feedback and instruction from contributor Sara Madsen. NEW in MasteringChemistry is the Chemistry Primer, a diagnostic and remediation tool that provides pre-built assignments designed to get readers up to speed on Chemistry and Math skills at the beginning of the course so they come to class prepared to delve more deeply into topics.



Also available as a Pearson eText or packaged with Mastering Chemistry

Pearson eText is a simple-to-use, mobile-optimized, personalized reading experience that can be adopted on its own as the main course material. It lets students highlight, take notes, and review key vocabulary all in one place, even when offline. Seamlessly integrated videos and other rich media engage students and give them access to the help they need, when they need it. Educators can easily share their own notes with students so they see the connection between their eText and what they learn in class – motivating them to keep reading, and keep learning.

Mastering Chemistry is the leading online homework, tutorial, and assessment system, designed to improve results by engaging students before, during, and after class with powerful content. Instructors ensure students arrive ready to learn by assigning educationally effective content before class, and they encourage critical thinking and retention with in-class resources such as Learning Catalytics™. Students can further master concepts after class through traditional and adaptive homework assignments that provide hints and answer-specific feedback. The Mastering gradebook records scores for all automatically graded assignments in one place, while diagnostic tools give instructors access to rich data to assess student understanding and misconceptions.

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Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry.

The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function.

This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.

The complex roles of glutathione and sulfur amino acids in human health

Glutathione (γ-L-glutamyl-L-cysteinylglycine, GSH) is a major antioxidant acting as a free radical scavenger that protects the cell from reactive oxygen species (ROS). Sulfur amino acids (SAAs), such as methionine and cysteine, play a critical role in the maintenance of health. GSH depletion as well as alterations of SAA metabolism are linked to a host of disease states including liver cirrhosis, various pulmonary diseases, myocardial ischemia and reperfusion injury, aging, Parkinson's disease, Alzheimer's disease, sepsis, and others. This book provides researchers with a comprehensive review of the biochemistry, absorption, metabolism, biological activities, disease prevention, and health promotion of glutathione and sulfur amino acids.

The twenty-two chapters explore such topics as:

Chemistry, absorption, transport, and metabolism of GSH and sulfur amino acids Antioxidant and detoxification properties of GSH and sulfur amino acids, highlighting the enzymatic systems involved in antioxidant defenses Biological activities of GSH and sulfur amino acids and their role in modulating cell processes Role of GSH and sulfur amino acid deficiency and alteration in the onset of diseases and in aging Protective effects exerted by GSH and sulfur amino acids when used as drugs, functional foods, and nutraceuticals in humans and animals

Special attention is paid to the molecular mechanisms for the modulation of transcription factors and enzyme activities, as well as the nutritional and therapeutic significance of dietary sulfur amino acids as shown in human and animal models.

With more than 2,000 scientific references, this book provides food scientists, nutritionists, biochemists, food technologists, chemists, molecular biologists, and public health professionals with a comprehensive and up-to-date examination of glutathione and sulfur amino acids in human health and disease.

Since the publication of the first edition of Chemistry of Protein Conjugation and Cross-Linking in 1991, new cross-linking reagents, notably multifunctional cross-linkers, have been developed and synthesized. The completion of the human genome project has opened a new area for studying nucleic acid and protein interactions using nucleic acid cross-linking reagents, and advances have also been made in the area of biosensors and microarray biochips for the detection and analysis of genes, proteins, and carbohydrates. In addition, developments in physical techniques with unprecedented sensitivity and resolution have facilitated the analysis of cross-linked products.

Updated to reflect the advances of the 21st century, this book offers:

An overview of the chemical principles underlying the processes of cross-linking and conjugation A thorough list of cross-linking reagents published in the literature since the first edition, covering monofunctional, homobifunctional, heterobifunctional, multifunctional, and zero-length cross-linkers Reviews of the use of these reagents in studying protein tertiary structures, geometric arrangements of subunits within complex proteins and nucleic acids, near-neighbor analysis, protein-to-protein or ligand–receptor interactions, and conformational changes of biomolecules Discusses the application of immunoconjugation for immunoassays, immunotoxins for targeted therapy, microarray technology for analysis of various biomolecules, and solid state chemistry for immobilizations

This book covers in detail the mechanisms for how energy is managed in the human body. The basic principles that elucidate the reactivity and physical interactions of matter are addressed and quantified with simple approaches. Three-dimensional representations of molecules are presented throughout the book so molecules can be viewed as unique entities in their shape and function.

The book is focused on the molecular mechanisms of cellular processes in the context of human physiological situations such as fasting, feeding and physical exercise, in which metabolic regulation is highlighted. Furthermore the book uses key historical experiments that opened up new concepts in Biochemistry to further illustrate how the human body functions at molecular level, helping students to appreciate how scientific knowledge emerges.

This book also:

Elucidates the foundations of the molecular events of life


Uses key historical experiments that opened up new concepts in Biochemistry to further illustrate how the human body functions at molecular level, helping students to appreciate how scientific knowledge emerges

Provides realistic representations of molecules throughout the book

Advance Praise for Integrative Human Biochemistry

“This textbook provides a modern and integrative perspective of human biochemistry and will be a faithful companion to health science students following curricula in which this discipline is addressed. This textbook will be a most useful tool for the teaching community.”

–Joan Guinovart

Director of the Institute for Research in Biomedicine, Barcelona, Spain

President-elect of the International Union of Biochemistry and Molecular Biology, IUBMB


The fully revised and expanded fourth edition of Plant Biochemistry presents the latest science on the molecular mechanisms of plant life. The book not only covers the basic principles of plant biology, such as photosynthesis, primary and secondary metabolism, the function of phytohormones, plant genetics, and plant biotechnology, but it also addresses the various commercial applications of plant biochemistry. Plant biochemistry is not only an important field of basic science explaining the molecular function of a plant, but is also an applied science that is in the position to contribute to the solution of agricultural and pharmaceutical problems.

Plants are the source of important industrial raw material such as fat and starch but they are also the basis for the production of pharmaceutics. It is expected that in the future, gene technology will lead to the extensive use of plants as a means of producing sustainable raw material for industrial purposes. As such, the techniques and use of genetic engineering to improve crop plants and to provide sustainable raw materials for the chemical and pharmaceutical industries are described in this edition. The latest research findings have been included, and areas of future research are identified.

Offers the latest research findings in a concise and understandable mannerPresents plant metabolism in the context of the structure and the function of plantsIncludes more than 300 two-color diagrams and metabolic schemesCovers the various commercial applications of plant biochemistryProvides extensive references to the recent scientific literature
A thrilling tale of encounters with nature’s masters of biochemistry

From the coasts of Indonesia to the rainforests of Peru, venomous animals are everywhere—and often lurking out of sight. Humans have feared them for centuries, long considering them the assassins and pariahs of the natural world.

Now, in Venomous, the biologist Christie Wilcox investigates and illuminates the animals of our nightmares, arguing that they hold the keys to a deeper understanding of evolution, adaptation, and immunity. She reveals just how venoms function and what they do to the human body. With Wilcox as our guide, we encounter a jellyfish with tentacles covered in stinging cells that can kill humans in minutes; a two-inch caterpillar with toxic bristles that trigger hemorrhaging; and a stunning blue-ringed octopus capable of inducing total paralysis. How do these animals go about their deadly work? How did they develop such intricate, potent toxins? Wilcox takes us around the world and down to the cellular level to find out.

Throughout her journey, Wilcox meets the intrepid scientists who risk their lives studying these lethal beasts, as well as “self-immunizers” who deliberately expose themselves to snakebites. Along the way, she puts her own life on the line, narrowly avoiding being envenomated herself. Drawing on her own research, Wilcox explains how venom scientists are untangling the mechanisms of some of our most devastating diseases, and reports on pharmacologists who are already exploiting venoms to produce lifesaving drugs. We discover that venomous creatures are in fact keystone species that play crucial roles in their ecosystems and ours—and for this alone, they ought to be protected and appreciated.

Thrilling and surprising at every turn, Venomous will change everything you thought you knew about the planet’s most dangerous animals.

The aim of the Protein Reviews is to serve as a publication vehicle for review articles that focus on crucial current vigorous aspects of protein structure, function, evolution and genetics. The volumes will appear online before they are published in a printed book. Articles are selected according to their importance to the understanding of biological systems, their relevance to the unravelling of issues associated with health and disease or their impact on scientific or technological advances and developments.

Volume 19 focusses on Purinergic receptors, also termed purinoceptors. These are plasma membrane proteins present in nearly all mammalian tissues. They participate in a number of cell functions that include proliferation and migration of neural stem cells, vascular reactivity, apoptosis and cytokine secretion and have been associated with learning and memory, feeding conduct, movement and sleep. They facilitate relaxation of smooth muscle of the gut in response to adenosine (P1 receptors) or ATP (P2 receptors).

The chapters in this volume are authored by experts in the field. They deal with aspects of structure and biological activity of selected receptor proteins. The first chapter in this volume reviews the current research on the Mechanism of channel gating and regulation of the activity of calcium-activated chloride channel ANO1. This is followed by a chapter dealing with Structure and function of the two-component cytotoxins of Staphylococcus aureus and a chapter on Membrane Fusion and Infection involving the Influenza virus Hemagglutinin. The fourth chapter reviews the impact of arrhythmogenic mutations through the structural determination of the L-type voltage-gated calcium channel. Then there is a chapter that discusses some open questions pertaining to histone post-translational modifications and nucleosome organization in transcriptional regulation. The next chapter deals with regulation of the extracellular SERPINA5 (protein C inhibitor) penetration through cellular membranes. This is followed by a chapter on coding of Class I and II aminoacyl-tRNA synthetases; a chapter on regulation of nephrin phosphorylation in diabetes and chronic kidney injury and a chapter on The Structure-Forming Juncture in oxidative protein folding and the events in the ER. Finally the last chapter deals with the polyspecificity of anti-lipid antibodies and its relevance to the development of autoimmunity. This volume is intended for research scientists, clinicians, physicians and graduate students in the fields of biochemistry, cell biology, molecular biology, immunology and genetics.

“This excellent work fills the need for an upper-level graduate course resource that examines the latest biochemical, biophysical, and molecular biological methods for analyzing the structures and physical properties of biomolecules... This reviewer showed [the book] to several of his senior graduate students, and they unanimously gave the book rave reviews. Summing Up: Highly recommended...” CHOICE

Chemical biology is a rapidly developing branch of chemistry, which sets out to understand the way biology works at the molecular level. Fundamental to chemical biology is a detailed understanding of the syntheses, structures and behaviours of biological macromolecules and macromolecular lipid assemblies that together represent the primary constituents of all cells and all organisms. The subject area of chemical biology bridges many different disciplines and is fast becoming an integral part of academic and commercial research.

This textbook is designed specifically as a key teaching resource for chemical biology that is intended to build on foundations lain down by introductory physical and organic chemistry courses. This book is an invaluable text for advanced undergraduates taking biological, bioorganic, organic and structural chemistry courses. It is also of interest to biochemists and molecular biologists, as well as professionals within the medical and pharmaceutical industry.

Key Features:

A comprehensive introduction to this dynamic area of chemistry, which will equip chemists for the task of understanding and studying the underlying principles behind the functioning of biological macro molecules, macromolecular lipid assemblies and cells. Covers many basic concepts and ideas associated with the study of the interface between chemistry and biology. Includes pedagogical features such as: key examples, glossary of equations, further reading and links to websites. Clearly written and richly illustrated in full colour.
Bioconjugate Techniques is the essential guide to the modification and crosslinking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. Armed with this information and the abundant protocols provided, readers will form unique complexes that can be used for detecting, quantifying, and targeting important analytes.
This book helps readers make: high activity antibody-enzymes conjugates, immunotoxins, immunogen complexes, liposome conjugates; as well as biotinylated molecules, avidin or streptavidin conjugates, colloidal gold labeled proteins, PEG or dextran complexes, labeled oligonucleotide probes, and fluorescently tagged or radiolabeled molecules.This book is the first to thoroughly capture the entire field of bioconjugate chemistry in a single volumeServes as a practical guide to modification and cross-linking technology for research, diagnostics, and therapeuticsProvides useful, detailed, easy-to-follow, step-by-step protocolsContains easy-to-read, and easy-to-understand key concepts for making bioconjugates of all typesEfficiently covers the chemistry of bioconjugation, the major reagents available for modification and cross-linking, and the application of these reagents to the synthesis of highly active conjugatesCites over more than references keyed to concepts covered in the bookUses more than 600 figures to illustrate bioconjugate reagents, their reactions, and applicationsSuggests sources for all key reagents
General Description of Volume:
Volume 51 includes reviews papers on cyclic AMP, kinases, polypeptide hormones, steroid hormone receptors, related genes, and members of the gene family.
General Description of Series:
Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish up-to-date synthetic reviews of interest to endocrinologists and biochemists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. Now, new discoveries have proved that several of the vitamins function as hormones and many of the substances inferred by the title of the Serial function in signal transduction processes. Accordingly, the editor-in-chief has expanded the scope of the serial to reflect this newer understanding of function-structure relationships in cellular communication. The newly modified editorial board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Vitamins and Hormones continues to publish up-to-date synthetic reviews of interest to endocrinologists and biochemists. Others will increasingly turn to this series for comprehensive reviews by leading researchers in this and related disciplines.
Gain a thorough understanding of the principles ofbiochemistry as they relate to the study of clinical medicine

A Doody's Core Title for 2017!

THE BEST REVIEW FOR THE USMLE!

The Thirtieth Edition of Harper’s Illustrated Biochemistry combines outstanding full-colorillustrations with authoritative integrated coverage of biochemical disease and clinical information. Using brevity and numerous medically relevant examples, Harper's presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school.

All fifty-eight chapters emphasize the medical relevance of biochemistry

Full-color presentation includes more than 600 illustrations Each chapter includes a section on BiomedicalImportance and a summary of the topics covered Review questions follow each of the eleven sections Case studies in every chapter emphasize the clinical relevance to biochemistry NEW coverage of toxic naturally-occurring amino acids; extraterrestrial biomolecules; computer-aided drug design; the role of complement cascade in bacterial and viral infection; secreted mediators of cell-cell signaling between leukocytes; the role of mast cells, basophils, andeosinophils; and the hazard of antioxidants that down-regulate radical signaling for apoptosis and increase risk of cancer

Applauded by medical students for its current and engaging style, Harper's Illustrated Biochemistry is an essential for USMLE review and the single best reference for learning the clinical relevance of any biochemistry topic.

Brought to you in a thorough yet accessible manner, the new edition of Medical Biochemistry gives access to all of the latest information on basic and clinically focused genetic and molecular biology. Featuring a team of contributors that includes investigators involved in cutting-edge research as well as experienced clinicians, this updated medical textbook offers a unique combination of both research and practice that's ideal for today's problem-based integrated courses.Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Relate biochemistry to everyday practice with the help of Clinical Boxes integrated into the text, and access in-depth coverage of important topics - including recent research in biochemistry - through Advanced Concept Boxes.Test your knowledge and improve retention with Active Learning Boxes at the conclusion of each chapter, and quickly review the most common lab tests performed with convenient Clinical Test Boxes.Effectively study the most updated information in biochemistry with the help of a dynamic, full-color design.Better understand the relationship between science and clinical practice with material organized by organ rather than system. Gain a thorough understanding of biomarkers and their uses with brand-new information on the subject. Access today's most recent research regarding Gene Therapy, Proteomics and Recombinant DNA Techniques, Role of Kidney in Metabolism, and Neurochemistry.
Extraordinary color illustrations make biochemistry concepts easy to understand and retain

Providing a powerful visual overview of the entire spectrum of human biochemistry, the third edition of the popular Color Atlas of Biochemistry is an ideal reference and study aid. It utilizes the signature Flexibook format, consisting of double-page spreads with clear explanatory text on the left-hand page and exquisitely detailed full-color graphics on the right. These bite-sized learning capsules ensure that your review of any given topic is quick, efficient, and comprehensive, allowing you to target the exact information you need for classroom and exam success.

New features of this bestselling review book:

Increased focus on pathobiochemical aspects and clinical correlations, especially useful for exam preparation in the clinical sciencesNew and expanded sections on the immune and digestive systems, motor proteins, transport processes, blood clotting and fibrinolysis, biochemistry of fatty tissue, metabolic integration, neurotransmitters and their receptors, signal transduction, and much more!Symbols for atoms, biomolecules, coenzymes, biochemical processes, and chemical reactions are color-coded to promote quick comprehension Computer graphics that provide simulated 3D representations of important molecules, making complex subject matter tangibleConvenient color thumb index that guides you quickly through the book

This superb didactic atlas has been used by medical and health science students worldwide since its first publication in German in 1994. It has since been translated into 9 languages and has been revised and updated regularly ever since. Its unrivalled illustrations, concise text, and focused presentation all combine to create an excellent, high-yield study guide.

Get the most from your study time, and experience a realistic USMLE simulation with Rapid Review Biochemistry, 3rd Edition, by Drs. John W. Pelley, and Edward F. Goljan. This new reference in the highly rated Rapid Review Series is formatted as a bulleted outline with photographs, tables, and figures that address all the biochemistry information you need to know for the USMLE. And with Student Consult functionality, you can become familiar with the look and feel of the actual exam by taking a timed or a practice online test that includes 350 USMLE-style questions.

Author, John Pelley, wins 2010 Alpha Omega Alpha Robert J. Glaser Distinguished Teacher Award

John Pelley PhD, an associate author of two popular medical review titles, Rapid Review Biochemistry, and Elsevier's Integrated Review Biochemistry has won the 2010 Alpha Omega Alpha (AOA) Robert J. Glaser Distinguished Teacher Award. The award was established by the AOA medical honor society in 1988 to recognize faculty members who have distinguished themselves in medical student education. He is nationally known for applying concept mapping, a learning technique that focuses on building patterns and relationships to concepts, to medical education.

Review the most current information with completely updated chapters, images, and questions.

Profit from the guidance of series editor, Dr. Edward Goljan, a well-known author of medical review books, who reviewed and edited every question.

Take a timed or a practice test online with more than 350 USMLE-style questions and full rationales for why every possible answer is right or wrong.

Access all the information you need to know quickly and easily with a user-friendly, two-color outline format that includes High-Yield Margin Notes. Study and take notes more easily with the new, larger page size.

Practice with a new testing platform on USMLE Consult that gives you a realistic review experience and fully prepares you for the exam.
Get the BIG PICTURE of Medical Biochemistry – and target what you really need to know to ace the course exams and the USMLE Step 1

300 FULL-COLOR ILLUSTRATIONS

Medical Biochemistry: The Big Picture is a unique biochemistry review that focuses on the medically applicable concepts and techniques that form the underpinnings of the diagnosis, prognosis, and treatment of medical conditions. Those preparing for the USMLE, residents, as well as clinicians who desire a better understanding of the biochemistry behind a particular pathology will find this book to be an essential reference. Featuring succinct, to-the-point text, more than 300 full-color illustrations, and a variety of learning aids, Medical Biochemistry: The Big Picture is designed to make complex concepts understandable in the shortest amount of time possible.

This full-color combination text and atlas features:

Progressive chapters that allow you to build upon what you’ve learned in a logical, effective manner Chapter Overviews that orient you to the important concepts covered in that chapter Numerous tables and illustrations that clarify and encapsulate the text Sidebars covering a particular disease or treatment add clinical relevance to topic discussed Essay-type review questions at the end of each chapter allow you to assess your comprehension of the major topics USMLE-style review questions at the end of each section Three appendices, including examples of biochemically based diseases, a review of basic biochemical techniques, and a review of organic chemistry/biochemistry
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