In Elvis: My Best Man, a heartfelt, entertaining, and long-awaited contribution to our understanding of Elvis Presley and the early days of rock ’n’ roll, George Klein writes with great affection for the friend he knew—about who the King of Rock ’n’ Roll really was and how he acted when the stage lights were off. This fascinating chronicle of boundary-breaking and music-making through one of the most intriguing and dynamic stretches of American history overflows with insights and anecdotes from someone who was in the middle of it all. From the good times at Graceland to hanging out with Hollywood stars to butting heads with Elvis’s iron-handed manager, Colonel Tom Parker, to making sure that Elvis’s legacy is fittingly honored, GK was a true friend of the King and a trailblazer in the music industry in his own right.
From the Hardcover edition.
Clinical Electrophysiology Review, Second Edition is a unique approach to EP, serving partly as a case guide and partly as a workbook to challenging studies in advanced electrodiagnostics. It provides physicians with a clinically relevant approach to the interpretation of electrophysiograms (used to measure heart rhythm disorders).
Clinical Electrophysiology Review, also serves as an excellent resource for candidates taking the electrophysiology board examination. It includes liberal use of illustrations to help the reader recognize common rhythym disturbances and uncommon arrhythmias, such as tachycardia and bradycardia. The new edition will include completely updated cases and tracings, and will reflect advances in technology since the first edition published.
New Paradigms for the Treatment of Cancer: The Role of Anti-aiogenesis AgentsThe Hepatocyte Growth Factor/Met Pathway in Development, Tumorigenesis, and B-Cell DifferentiationClinical Targets for Anti-metastasis TherapyAnimal Models of Melanoma: Recent Advances and Future ProspectsThe Indispensable Role of Microenvironment in the Natural History of Low-Grade B-Cell NeoplasmsEpstein-Barr Virus Latency: LMP2, a Regulator or Means for Epstein-Barr BirusBiochemistry and Pathological Importance of Mucin-Associated Antigens in Gastrointenstinal NeoplasiaStudies on Polyomavirus Persistence and Polyomavirus-Induced Tumor Development in Relation to the Immune System
Contains two Foundations in Cancer Research articles with personal accounts by prominent biologists on their careers in cancer researchPresents overviews of the role of p53 in breast cancer and cell cycle regulationDescribes the regulatory role of cyclins and cyclin dependent kinases in DNA replication and cell divisionExplains the puzzling link between HIV infection and Kaposis SarcomaIncludes models for retrovirus-induced tumorigenesis and foreign DNA insertion into mammalian genomes
*Suppressor and Oncogenic Roles of TGF-aand Its Signaling Pathways in Tumorigenesis
*Hereditary Diffuse Gastric Disease
*Role of Heparan Sulfate Proteoglycans in Cell Signaling and Cancer
*The Occurrence and Significance of V-Vene Mutations in B Cell-Derived Human Malignancy
*MHC Antigens and Tumor Escape from Immune Surveillance
*Foundations in Cancer Research: The Role of Selection in Progressive Neoplastic Transformation
*ATM: Genomic Stability, Neuronal Development, and Cancer Cross Paths
* Highlights of Volume 64:
* Interactions of papilloma virus proteins with tumor suppressors
* Retinoblastoma tumor suppressor protein
* SH2 and SH3 domains in tyrosing kinase signal transduction
* Oncogene activation in mammary tumors
* Polyomavirus middle T antigen phenotypes in transgenic animals
* Protein kinase C and FCg receptors in neoplastic disease
* Transgenic mouse models for molecular carcinogenesis
Cell Transformation by the E7 Oncoprotein of HPV Type 16: Interactions with Nuclear and Cytoplasmic Target ProteinsTumor Invasion: Role of Growth Factor-Induced Cell MotilityNon-Enzymatic Interactions Between Proteinases and the Cell Surface: Novel Roles in Normal and Malignant Cell PhysiologyMolecular Pathogenesis of AIDS-Associated Kaposi's Sarcoma: Growth and ApoptosisPerspectives on Cancer Chemoprevention Research and Drug Development
* Gene Expression in Inherited Breast Cancer
* Multiparameter Analyses of CellCycle Regulatory Proteins in Human Breast Cancer: A Key to Definition of Separate Pathways in Tumorigenesis
* Rho GTPases in Transformation and Metastasis
* The myc Oncogene: Marvelously Complex
* Genetic Requirements for the Episomal Maintenance of Oncogenic Herpevirus Genomes
* Treatment of Epstein-Barr Virus-Associated Malignancies with Specific T Cells
* Role of Glycogen Synthase Kinase-3 in Cancer: Regulation Wnts and Other Signaling Pathways
* Chronic Immune Activation and Inflammation in the Pathogenesis of AIDS and Cancer
* Molecular Biology of Hodgkin's Lymphoma
Involvement of Platelet-Derived Growth Factor in Disease: Development of Specific AntagonistsTumor Suppression Activity of Adenovirus E1a Protein: Anoikis and the Epithelial PhenotypeComparative Analysis of the Transforming Mechanisms of EBV, KSHV, and HVSGenetic Predisposition and Somatic Diversification in Tumor Development and ProgressionPrimary Effusion Lymphoma - A Liquid Phase Lymphoma of Fluid-Filled Body CavitiesThe Dimensions of Antigen Recognition and the Levels of Immunological SpecificityTopoisomerase I-Mediated DNA Damage
Provides invaluable information on the exciting and fast-moving field of cancer researchOutstanding and original reviews are presented on a variety of topics
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including Mdm2 - a regulator of cell growth and death; the systematic progression of human cancer; seizing of T-cells by human T-cell leukemia/lymphoma virus type II; host cell dependent expression of latent Epstein-Barr virus genomes; and gene expression profiling of renal cell carcinoma and its implications in diagnosis prognosis and therapeutics.
In Volume 65, the Editors present a marvelous group of seven new Foundations chapters within a single volume. Subsequent volumes will return to the orginal format of one or two Founations chapters in each volume of the Serial.
Describes the foundation for today's unified field of cancer researchProvides the history of specific aspects of cancer research in personal overviewsReviews the origins of tumor and retro-viruses, and current concepts of carcinogenesis, genetics, tumor progression, and growth dysregulationIncludes a biographical sketch of Sol Speigelman written by Gunther Stent
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics.
The Yin Yang of TCF/b-Catenin SignallingBiochemical and Clinical Implications of the Erb/HER Signaling Network of Growth Factor Receptorsp53 and Human Cancer: The First Ten Thousand MutationsMacrophage Stimulating ProteinCD44 Glycoproteins in Colorectal Cancer; Expression; Function; and Prognostic ValueA Simple Modes for Carcinogenesis of Colorectal Cancer with Microsatellite Instability
Cancer is not one disease, but a group of diseases in which malignant cells grow out of control and spread to other parts of the body. Eventually these cells form a visible mass or tumor. Appropriate treatment for cancer depends on what kind of cancer a person has. The type of cancer is determined by the organ the cancer starts in, the kind of cell from which it is derived, and the appearance of the cancer cells.
A "Foundations in Cancer Research" article by Alfred G. Knudson, a personal account of his career studying mutation and cancerA developmental model of progenitor cell oncogenesis based on a disruption of transcriptional controlPathways of chromosome alteration in human epithelial cancers, using colorectal, breast, lung, and endometrial cancers as examplesA review of the genetics of murine lung tumorsMolecular pathogenesis of AIDS-related lymphomasHLA class I antigens in human tumors, focusing on abnormal MHC expression detected in human tumors and the biological role these alterations may have in tumor developmentA summary of the information obtained by the molecular characterization of EBV diversity and discussion of its relevance for viral epidemiology, transmission, and pathogenesisThe role of scatter factor in angiogenesisThe role of the VEGF-FH receptor system in normal and tumor angiogenesis
From a renowned historian comes a groundbreaking narrative of humanity’s creation and evolution—a #1 international bestseller—that explores the ways in which biology and history have defined us and enhanced our understanding of what it means to be “human.”
One hundred thousand years ago, at least six different species of humans inhabited Earth. Yet today there is only one—homo sapiens. What happened to the others? And what may happen to us?
Most books about the history of humanity pursue either a historical or a biological approach, but Dr. Yuval Noah Harari breaks the mold with this highly original book that begins about 70,000 years ago with the appearance of modern cognition. From examining the role evolving humans have played in the global ecosystem to charting the rise of empires, Sapiens integrates history and science to reconsider accepted narratives, connect past developments with contemporary concerns, and examine specific events within the context of larger ideas.
Dr. Harari also compels us to look ahead, because over the last few decades humans have begun to bend laws of natural selection that have governed life for the past four billion years. We are acquiring the ability to design not only the world around us, but also ourselves. Where is this leading us, and what do we want to become?
Featuring 27 photographs, 6 maps, and 25 illustrations/diagrams, this provocative and insightful work is sure to spark debate and is essential reading for aficionados of Jared Diamond, James Gleick, Matt Ridley, Robert Wright, and Sharon Moalem.
In The Disappearing Spoon, bestselling author Sam Kean unlocked the mysteries of the periodic table. In THE VIOLINIST'S THUMB, he explores the wonders of the magical building block of life: DNA.
There are genes to explain crazy cat ladies, why other people have no fingerprints, and why some people survive nuclear bombs. Genes illuminate everything from JFK's bronze skin (it wasn't a tan) to Einstein's genius. They prove that Neanderthals and humans bred thousands of years more recently than any of us would feel comfortable thinking. They can even allow some people, because of the exceptional flexibility of their thumbs and fingers, to become truly singular violinists.
Kean's vibrant storytelling once again makes science entertaining, explaining human history and whimsy while showing how DNA will influence our species' future.
Ebola, SARS, Hendra, AIDS, and countless other deadly viruses all have one thing in common: the bugs that transmit these diseases all originate in wild animals and pass to humans by a process called spillover. In this gripping account, David Quammen takes the reader along on this astonishing quest to learn how, where from, and why these diseases emerge and asks the terrifying question: What might the next big one be?
FINANCIAL TIMES (LONDON)
World renowned scientist Carl Sagan and acclaimed author Ann Druyan have written a ROOTS for the human species, a lucid and riveting account of how humans got to be the way we are. It shows with humor and drama that many of our key traits--self-awareness, technology, family ties, submission to authority, hatred for those a little different from ourselves, reason, and ethics--are rooted in the deep past, and illuminated by our kinship with other animals. Astonishing in its scope, brilliant in its insights, and an absolutely compelling read, SHADOWS OF FORGOTTEN ANCESTORS is a triumph of popular science.
From the Trade Paperback edition.
HarperPerennial Classics brings great works of literature to life in digital format, upholding the highest standards in ebook production and celebrating reading in all its forms. Look for more titles in the HarperPerennial Classics collection to build your digital library.
Why are rates of conditions like autism, asthma, obesity, and allergies exploding at an unprecedented pace? Why are humans living longer, getting smarter, and having far fewer kids? How might your lifestyle affect your unborn children and grandchildren? How will gene-editing technologies like CRISPR steer the course of human evolution? If Darwin were alive today, how would he explain this new world? Could our progeny eventually become a different species—or several?
In Evolving Ourselves, futurist Juan Enriquez and scientist Steve Gullans conduct a sweeping tour of how humans are changing the course of evolution—sometimes intentionally, sometimes not. For example:
• Globally, rates of obesity in humans nearly doubled between 1980 and 2014. What’s more, there’s evidence that other species, from pasture-fed horses to lab animals to house cats, are also getting fatter.
• As reported by U.S. government agencies, the rate of autism rose by 131 percent from 2001 to 2010, an increase that cannot be attributed simply to increases in diagnosis rates.
• Three hundred years ago, almost no one with a serious nut allergy lived long enough to reproduce. Today, despite an environment in which food allergies have increased by 50 percent in just over a decade, 17 million Americans who suffer from food allergies survive, thrive, and pass their genes and behaviors on to the next generation.
• In the pre-Twinkie era, early humans had quite healthy mouths. As we began cooking, bathing, and using antibiotics, the bacteria in our bodies changed dramatically and became far less diverse. Today the consequences are evident not only in our teeth but throughout our bodies and minds.
Though these harbingers of change are deeply unsettling, the authors argue that we are also in an epoch of tremendous opportunity. New advances in biotechnology help us mitigate the cruel forces of natural selection, from saving prematurely born babies to gene therapies for sickle cell anemia and other conditions. As technology like CRISPR enables us to take control of our genes, we will be able to alter our own species and many others—a good thing, given that our eventual survival will require space travel and colonization, enabled by a fundamental redesign of our bodies.
Future humans could become great caretakers of the planet, as well as a more diverse, more resilient, gentler, and more intelligent species—but only if we make the right choices now.
Intelligent, provocative, and optimistic, Evolving Ourselves is the ultimate guide to the next phase of life on Earth.
From the Hardcover edition.
Early studies of the human brain used a simple method: wait for misfortune to strike -- strokes, seizures, infectious diseases, horrendous accidents -- and see how victims coped. In many cases their survival was miraculous, if puzzling. Observers were amazed by the transformations that took place when different parts of the brain were destroyed, altering victims' personalities. Parents suddenly couldn't recognize their own children. Pillars of the community became pathological liars. Some people couldn't speak but could still sing.
In The Tale of the Dueling Neurosurgeons, Sam Kean travels through time with stories of neurological curiosities: phantom limbs, Siamese twin brains, viruses that eat patients' memories, blind people who see through their tongues. He weaves these narratives together with prose that makes the pages fly by, to create a story of discovery that reaches back to the 1500s and the high-profile jousting accident that inspired this book's title.* With the lucid, masterful explanations and razor-sharp wit his fans have come to expect, Kean explores the brain's secret passageways and recounts the forgotten tales of the ordinary people whose struggles, resilience, and deep humanity made neuroscience possible.
*"The Tale of the Dueling Neurosurgeons" refers to the case of French king Henri II, who in 1559 was lanced through the skull during a joust, resulting in one of the most significant cases in neuroscience history. For hundreds of years scientists have gained important lessons from traumatic accidents and illnesses, and such misfortunes still represent their greatest resource for discovery.
Whether it is asthma, food or pollen allergies, type-1 diabetes, lupus, multiple sclerosis, or Crohn’s disease, everyone knows someone who suffers from an allergic or autoimmune disorder. And if it appears that the prevalence of these maladies has increased recently, that’s because it has—to levels never before seen in human history. These days no fewer than one in five—and likely more—Americans suffers from one of these ailments. We seem newly, and bafflingly, vulnerable to immune system malfunction. Why? Science writer Moises Velasquez-Manoff explains the latest thinking about this problem and explores the remarkable new treatments in the works.
In the past 150 years, improved sanitation, water treatment, and the advent of vaccines and antibiotics have saved countless lives, nearly eradicating diseases that had plagued humanity for millennia. But now, a growing body of evidence suggests that the very steps we took to combat infections also eliminated organisms that kept our bodies in balance. The idea that we have systematically cleaned ourselves to illness challenges deeply entrenched notions about the value of societal hygiene and the harmful nature of microbes. Yet scientists investigating the rampant immune dysfunction in the developed world have inevitably arrived at this conclusion. To address this global “epidemic of absence,” they must restore the human ecosystem.
This groundbreaking book explores the promising but controversial “worm therapy”—deliberate infection with parasitic worms—in development to treat autoimmune disease. It explains why farmers’ children so rarely get hay fever, why allergy is less prevalent in former Eastern Bloc countries, and how one cancer-causing bacterium may be good for us. It probes the link between autism and a dysfunctional immune system. It investigates the newly apparent fetal origins of allergic disease—that a mother’s inflammatory response imprints on her unborn child, tipping the scales toward allergy. In the future, preventive treatment—something as simple as a probiotic—will necessarily begin before birth.
An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results.
An Epidemic of Absence considers the critical immune stimuli we inadvertently lost as we modernized, and the modern ills we may be able to correct by restoring them. At stake is nothing less than our health, and that of our loved ones. Researchers, meanwhile, have the good fortune of living through a paradigm shift, one of those occasional moments in the progress of science when a radically new way of thinking emerges, shakes things up, and suggests new avenues of treatment. You’ll discover that you’re not you at all, but a bustling collection of organisms, an ecosystem whose preservation and integrity require the utmost attention and care.
Public sanitation and antibiotic drugs have brought about historic increases in the human life span; they have also unintentionally produced new health crises by disrupting the intimate, age-old balance between humans and the microorganisms that inhabit our bodies and our environment. As a result, antibiotic resistance now ranks among the gravest medical problems of modern times. Good Germs, Bad Germs addresses not only this issue but also what has become known as the "hygiene hypothesis"— an argument that links the over-sanitation of modern life to now-epidemic increases in immune and other disorders. In telling the story of what went terribly wrong in our war on germs, Jessica Snyder Sachs explores our emerging understanding of the symbiotic relationship between the human body and its resident microbes—which outnumber its human cells by a factor of nine to one! The book also offers a hopeful look into a future in which antibiotics will be designed and used more wisely, and beyond that, to a day when we may replace antibacterial drugs and cleansers with bacterial ones—each custom-designed for maximum health benefits.
But what does it mean?
Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life.
Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.