When a deadly diphtheria epidemic swept through Nome, Alaska, in 1925, the local doctor knew that without a fresh batch of antitoxin, his patients would die. The lifesaving serum was a thousand miles away, the port was icebound, and planes couldn't fly in blizzard conditions—only the dogs could make it. The heroic dash of dog teams across the Alaskan wilderness to Nome inspired the annual Iditarod Trail Sled Dog Race and immortalized Balto, the lead dog of the last team whose bronze statue still stands in New York City's Central Park. This is the greatest dog story, never fully told until now.
You may not know that you have Lyme. It can mimic every disease process including Chronic Fatigue Syndrome, Fibromyalgia, autoimmune conditions like MS, psychiatric conditions like depression and anxiety, and cause significant memory and concentration problems, mimicking early dementia. It is called the "Great Imitator," and inaccurate testing-combined with a fierce, ongoing debate that questions chronic infection-makes it difficult for sufferers to find effective care.
When Dr. Richard Horowitz moved to the Hudson Valley over two decades ago to start his own medical practice, he had no idea that he was jumping into a hotbed of Lyme disease. He would soon realize that many of the chronic disease diagnoses people were receiving were also the result of Lyme-and he would discover how once-treatable infections, in the absence of timely intervention, could cause disabling conditions. In a field where the number of cases is growing exponentially around the world and answers remain elusive, Dr. Horowitz has treated over 12,000 patients and made extraordinary progress. His plan represents a crucial paradigm shift, without which the suffering will continue.
In this book, Dr. Horowitz:
- Breaks new ground with a 16 Point Differential Diagnostic Map, the basis for his revolutionary Lyme treatment plan, and an overarching approach to treating all chronic illness.
- Introduces MSIDS, or Multiple Systemic Infectious Disease Syndrome, a new lens on chronic illness that may prove to be an important missing link.
- Covers in detail Lyme's leading symptoms and co-infections, including immune dysfunction, sleep disorders, chronic pain and neurodegenerative disorders - providing a unique functional and integrative health care model, based on the most up-to-date scientific research, for physicians and health care providers to effectively treat Lyme and other chronic illnesses.
Cutting through the frustration, misinformation and endless questions, Dr. Horowitz's enlightening story of medical discovery, science and politics is an all-in-one source for patients of chronic illness to identify their own symptoms and work with their doctors for the best possible treatment outcome.
At the height of WWI, history’s most lethal influenza virus erupted in an army camp in Kansas, moved east with American troops, then exploded, killing as many as 100 million people worldwide. It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease. Magisterial in its breadth of perspective and depth of research and now revised to reflect the growing danger of the avian flu, The Great Influenza is ultimately a tale of triumph amid tragedy, which provides us with a precise and sobering model as we confront the epidemics looming on our own horizon. John M. Barry has written a new afterword for this edition that brings us up to speed on the terrible threat of the avian flu and suggest ways in which we might head off another flu pandemic.
When Pamela Weintraub, a science journalist, learned that her oldest son tested positive for Lyme disease, she thought she had found an answer to the symptoms that had been plaguing her family for years—but her nightmare had just begun. Almost everything about Lyme disease turned out to be deeply controversial, from the microbe causing the infection, to the length and type of treatment and the kind of practitioner needed.
On one side of the fight, the scientists who first studied Lyme describe a disease transmitted by a deer tick that is hard to catch but easy to cure no matter how advanced the case. On the other side, rebel doctors insist that Lyme and a soup of "co-infections" cause a complicated spectrum of illness often dramatically different – and far more difficult to treat – than the original researchers claim. Instead of just swollen knees and a rash, patients can experience exhaustion, disabling pain, and a "Lyme fog" that leaves them dazed and confused. As patients struggle for answers, once-treatable infections become chronic.
In this nuanced picture of the intense controversy and crippling uncertainty surrounding Lyme disease, Pamela Weintraub sheds light on one of the angriest medical disputes raging today. The most comprehensive book ever written about the past, present and future of Lyme disease, Cure Unknown exposes the ticking clock of a raging epidemic and the vulnerability we all share.
Following introductory chapters on the nature, structure and function of bacteria, diagnostic methods and antibiotic use, the principles are then applied to each organ system. Here relevant aspects of epidemiology, pathogenesis, diagnosis, treatment and public health are covered. There are chapters on infection is a modern society, including the immuncompromised patient, and infection control in the hospital and community.
In the context of new problem-based curricula, this book will be welcomed especially by medical students, trainee physicians and microbiologists, laboratory biomedical scientists and nurses working in infection control.
Jennifer Lee Carrell transports readers back to the early eighteenth century to tell the tales of Lady Mary Wortley Montagu and Dr. Zabdiel Boylston, two iconoclastic figures who helped save London and Boston from the deadliest disease mankind has known.
Damaged Goods adds to our knowledge of how women are affected by living with chronic STDs and reveals the stages of their sexual- self transformation. From the anxiety of being diagnosed with an STD to issues of blame and shame, Nack-herself diagnosed with a cervical HPV infection-shows why these women feeling that they are "damaged goods," question future relationships, marriage, and their ability to have healthy children.
Complete and up-to-date, this book describes safer sex practices, testing protocols, and symptoms, and details commonly known treatments as well as significant recent medical advances—including new testing for the herpes virus, the vaccine against the human papilloma virus (HPV), and new discoveries about the effectiveness of spermicides and condoms. For each disease, Dr. Marr offers the latest Sexually Transmitted Disease Treatment Guidelines from the Centers for Disease Control and Prevention.
Forthright, compassionate, and practical, this guide is a trusted source of advice for anyone who is sexually active.
Grasp and retain vital concepts easilythanks to a user-friendly color-coded format, succinct text, key concept boxes, and dynamic illustrations.
Effectively review for problem-based courseswith the help of chapter introductions and "Lessons in Microbiology" text boxes that highlight the clinical relevance of the material, offer easy access to key concepts, and provide valuable review tools.
Approach microbiology by body system or by pathogenthrough an extensively cross-referenced "Pathogen Review" section.
Access the complete contents online at studentconsult.com, along with downloadable illustrations...150 multiple choice review questions... "Pathogen Parade"...and many other features to enhance learning and retention. Enhance your learning and absorb complex information in an interactive, dynamic way with Pathogen Parade – a quickly searchable online glossary of viruses, bacteria, and fungi.
Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventive medicine.A completely re-written chapter on this topic keeps abreast of the very latest findings.
Several themes explored in the book illustrate ways in which non-medical factors influence our views of a disease and our reaction to it. One of these themes is the tendency to focus blame for the spread of a disease on a particular group (e.g., women, blacks, sinners). The balance between protecting the rights of individuals and protecting the public health, in issues such as whether to quarantine the infected and whether to require mandatory testing for the disease, is another theme. A third theme is the persistent reluctance of many Americans to discuss venereal disease openly because it involves sex, a subject that we are often not comfortable talking about.
Vaccinated is not a biography; Hilleman's experience forms the basis for a rich and lively narrative of two hundred years of medical history, ranging across the globe and throughout time to take in a cast of hundreds, all caught up, intentionally or otherwise, in the story of vaccines. It is an inspiring and triumphant tale, but one with a cautionary aspect, as vaccines come under assault from people blaming vaccines for autism and worse. Paul Offit clearly and compellingly rebuts those arguments, and, by demonstrating how much the work of Hilleman and others has gained for humanity, shows us how much we have to lose.
Since its original publication in 2008, CURE UNKNOWN has become known as a nuanced, groundbreaking picture of the intense controversy and crippling uncertainty surrounding Lyme disease, and the only book of its kind. Award-winning journalist Pamela Weintraub reveals her personal struggle with Lyme after she and her family became seriously ill with the disease, and sheds light on one of the angriest medical disputes raging today.
In recent years, there have been many crucial updates (political, medical and scientific) to the Lyme story; the intense controversy has continued, new information has come out, and paradigm-shifting decisions made at the highest levels of government. In this brand-new final chapter of CURE UNKNOWN, originally published in the May 2013 revised edition, Pamela offers her unique, riveting take on the disease as it stands today, further exposing the ticking clock of a raging epidemic and offering sufferers new hope.
Emerging, re-emerging, and antibiotic-resistant infectious diseases continue to increase at an alarming rate throughout the world. Written for a wide range of health professionals, particularly nurses, this revised edition provides a comprehensive and up-to-date overview of these diseases: their epidemiology, clinical manifestations, prevention, and treatment.
With contributions by a multidisciplinary team of nurses, physicians, and infectious disease specialists, the book includes material on the most recent and important new emerging infectious diseases:
Avian influenza and SARSIssues of demographics and microbial resistanceSpecial topics, including bioterrorismBehavioral and cultural factorsInfectious etiologies of chronic diseasesTravel and recreational exposure
Each chapter is amply illustrated with clinical case examples to demonstrate the pitfalls in differential diagnosis and elucidate proper management and treatment. Valuable appendices provide critical reference information for each of the bacterial, viral, fungal, and parasitic diseases.
This book is written in the same engaging conversational style as the published reference book The Immune Response: Basic and Clinical Principles and conveys the same fascinating appeal of immunology. The authors bring clarity, readability and continuity of voice to an audience that requires only a brief survey of the most fundamental concepts in basic and clinical immunology. Primer to The Immune Response is beautifully illustrated with over 200 superb figures and 36 full-color plates, and further enhanced by the inclusion of 60 tables and 6 Appendices. Included with purchase of the book is website access to a captivating “Immunomovie" that truly brings the immune response to pathogens to life. This new and unique immunology textbook compactly but elegantly covers both basic and clinical principles.Over 200 elegant 2-4 color illustrations36 full-color plates of basic and clinical items of interestTake-home message and “Did You Get It? self-test quiz at the end of each chapter6 Appendices that provide topic enrichment60-minute "Immunomovie" illustrating the immune response to bacterial, viral and parasitic infections
Under the weather? Eminent lung specialist Neil Schachter, M.D., arms you with the knowledge you need to boost immunity and avoid illness. And when colds, flu, and other respiratory infections do strike, you'll know exactly how to relieve uncomfortable symptoms like congestion and fever.
In this book you'll find:Treatment plans for the most common respiratory infections, including colds, flu, bronchitis, pneumonia, sinusitis, and strep throatThe right way to use vitamin C and zinc to combat a coldThe important difference between a head cold and chest coldThe five best ways to quiet a coughThree signs that indicate if it's a cold or fluThree symptoms that signal it's time to call a doctorWhy humming five seconds a day can reduce risk of sinus problemsThe surprising reason why women catch more coldsAnd much more
With Dr. Schachter's guidance, you'll stay one step ahead of colds and flu.
Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.Completely updated, the 2e presents recent advances driven by new information on the genetics and genomics of the pathogenProvides the latest information concerning the epidemiology, diagnosis, treatment and prevention of toxoplasmosisOffers a single-source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians, and food scientists
Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitroCovers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodiesColor illustrations enhance explanations of the immune system
As a physician who has spent the better part of the last two decades chasing bugs all over the world -- from Ebola in Uganda, to polio in Pakistan, to SARS in Toronto, to the H1N1 influenza outbreak in Mexico -- Dr. Bonnie Henry, a leading epidemiologist (virus hunter) and public-health doctor, offers three simple rules to live by: clean your hands, cover your mouth when you cough, and stay at home when you have a fever. It all boils down to basic hygiene.
“… provides a valuable overview of the basic principles and issues pertaining to the pathogenesis and prevention of infectious diseases. The illustrations, the chapter summaries with relevant information, and the case studies are all particularly useful for the targeted readers. The book is well designed and manages to convey the general concepts of the various aspects of infectious diseases without overwhelming the reader with too much information… recommended for students, trainees, or physicians who desire a well-illustrated textbook that is easy to read and that addresses the basic aspects of infectious disease.” –Clinical Infectious Diseases, 2010
The study of infectious diseases has undergone major changes since its infancy when it was largely a documentation of epidemics. It has now evolved into a dynamic phenomenon involving the ecology of the infectious agent, pathogenesis in the host, reservoirs and vetors, as well as the complex mechanisms concerned in the spread of infection and the extent to which this spread occurs. Rapid globalization has led to unprecedented interest in infectious diseases worldwide and their effect on complex population dynamics including migration, famine, fire, war, and terrorism. It is now essential for public health officials to understand the basic science behind infectious disease and, likewise, students studying ID must have a broader understanding of the implications of infectious disease in a public health context as well as clinical presentation and prevention. The clear demand for an integrated approach has led to the publication of this text.
Check out the student companion site at www.wiley.com/go/shettyinfectiousdisease
The editors have built Infectious Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Infectious Diseases: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility.
This highly acclaimed book has been extensively revised and updated throughout to ensure all drug and dosage recommendations are accurate and in agreement with current guidelines. A new chapter on infections caused by Pneumocystis jirovecii has been added. The book has been designed to enable rapid information retrieval and to help clinicians make informed decisions about diagnosis and patient management. Each chapter concludes with a list of recent key publications which have been carefully selected to facilitate efficient access to further information on specific aspects of fungal infections.
Clinical microbiologists, infectious disease specialists, as well as dermatologists, hematologists and oncologists, can depend on this contemporary text for authoritative information and the background necessary to understand fungal infections.
* Offers almost a 20% expansion over the first edition
* Focuses specifically on viral pathogenesis unlike other texts where only a few chapters are devoted to the topic
* Neal Nathanson is one of the primary authorities in the field and has authored chapters on viral pathogenesis in two of the most well known virology and microbiology titles Field's Virology and Topley and Wilson's Microbiology
* Now in four color throughout!
* Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors
* Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement
* Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
* Discusses utility of adenoviral vectors in animal disease models
* Considers Federal Drug Administration regulations for human clinical trials
Immunotherapy of Cancerprovides information on cancer research related to inflammation and immunity, containing outstanding reviews by experts in the field. It is suitable for researchers and students who have an interest in cancer immunobiology.Provides information on cancer research, including outstanding and original reviewsCovers the current progress and emerging concepts in cancer inflammation, immunology, and immunotherapy Suitable for researchers and students studying, and interested in, the field of immunotherapy for cancerIdeal for those studying cancer inflammation, tumor immunology, cancer immunotherapy, dendritic cell, antigen presentation, immune checkpoint, myeloid-derived suppressor cells, macrophages, and tumor environments
This comprehensive, up-to-date volume aims to define issues and potential solutions to the challenges of antimicrobial resistance. The chapter authors are leading international experts on antimicrobial resistance among a variety of bacteria (Streptococcus pneumoniae, enteroccoci, staphylococci, gram-negative bacilli, mycobacteria species) viruses (HIV, herpesviruses), and fungi (Candida species, fusarium etc.). The chapters will explore the molecular mechanisms of drug resistance, the immunology and epidemiology of resistance strains, clinical implications and implications on research and lack thereof, and prevention and future directions. This volume will also describe the steps that researchers are taking to develop molecular methods for detecting resistance; develop drugs and other means to deal with newly-resistant organisms. A special chapter to address the issues on strategies to limit antimicrobial resistance propagation will be included in this volume.
The New Public Health will help students and practitioners understand factors affecting the reform process of health care organization and delivery. It links the classic public health issues such as environmental sanitation, health education, and epidemiology with the new issues of universal health care, economics, and management of health systems for the new century.Provides a comprehensive overview of public health from a global perspectiveAssesses health systems models of the United States, Russia, the United Kingdom, Germany, Canada, Scandinavian countries, and developing countries including China, Nigeria, and ColombiaAnalyzes critical issues of health economics, including forces associated with escalating costs and the strategies to control those costsDiscusses strategies for dealing with the many ramifications of managed careLinks medicine with the social sciences, technology, and health management issues as they evolve
New to this Edition: • Features expanded coverage of the evolution of parasitism and an extensive update to immunology of parasite–host interactions • Offers an enhanced art program featuring life-cycle illustrations and additional SEM and TEM micrographs • New Host Immune Response section for each organismPresents various parasites and examines how they interact with their hosts and respond to new treatmentsEasy to read with photographs, diagrams, and clinical case pictures throughout
Jan de Vries
Antibiotics were developed in the 1940s. Then, they were hailed as a huge breakthrough in the treatment of bacterial infections. Today, they are the most commonly prescribed drugs worldwide. But massive over-prescription of antibiotics has created its own problems. The advent of antibiotic-resistant organisms – or ‘superbugs’ – has led more and more people to demand alternatives.
Natural Alternatives to Antibiotics is a revised and updated version of Dr John McKenna’s international bestseller Alternatives to Antibiotics. First published in 1996 and translated into 16 languages, Alternatives to Antibiotics explains in simple, jargon-free language the variety of alternatives to antibiotics in treating infections. Dr McKenna compares conventional medicine and alternative medical approaches, highlighting the benefits and drawbacks of both.
In Natural Alternatives to Antibiotics, Dr McKenna looks at the various strains of infections which have become resistant since his international bestseller Alternatives to Antibiotics was published. Dr McKenna has expanded his sections on alternative, herbal, homeopathic and nutritional medicines, and shows directly that it is still possible to treat infections without antibiotics while still acknowledging the times that they may be necessary.Natural Alternatives to Antibiotics: Table of ContentsIntroduction
The History of AntibioticsBacterial Resistance to AntibioticsThe Use and Abuse of AntibioticsConventional and Alternative Medical ApproachesChildhood InfectionsHerbal MedicineHomeopathic MedicineNutritional MedicineNutritional SupplementsThe Role of Stress Conclusion