After four decades of assuming that the conquest of all infectous diseases was imminent, people on all continents now find themselves besieged by AIDS, drug-resistant tuberculosis, cholera that defies chlorine water treatment, and exotic viruses that can kill in a matter of hours.
Based on extensive interviews with leading experts in virology, molecular biology, disease ecology and medicine, as well as field research in sub-Saharan Africa, Western Europe, Central America and the United States, The Coming Plague takes readers from the savannas of eastern Bolivia to the rain forests of northern Zaire on a harrowing, fifty year journey through our battles with the microbes, and tells us what must be done to prevent the coming plague.
Ebola, SARS, Hendra, AIDS, and countless other deadly viruses all have one thing in common: the bugs that transmit these diseases all originate in wild animals and pass to humans by a process called spillover. In this gripping account, David Quammen takes the reader along on this astonishing quest to learn how, where from, and why these diseases emerge and asks the terrifying question: What might the next big one be?
Whether it is asthma, food or pollen allergies, type-1 diabetes, lupus, multiple sclerosis, or Crohn’s disease, everyone knows someone who suffers from an allergic or autoimmune disorder. And if it appears that the prevalence of these maladies has increased recently, that’s because it has—to levels never before seen in human history. These days no fewer than one in five—and likely more—Americans suffers from one of these ailments. We seem newly, and bafflingly, vulnerable to immune system malfunction. Why? Science writer Moises Velasquez-Manoff explains the latest thinking about this problem and explores the remarkable new treatments in the works.
In the past 150 years, improved sanitation, water treatment, and the advent of vaccines and antibiotics have saved countless lives, nearly eradicating diseases that had plagued humanity for millennia. But now, a growing body of evidence suggests that the very steps we took to combat infections also eliminated organisms that kept our bodies in balance. The idea that we have systematically cleaned ourselves to illness challenges deeply entrenched notions about the value of societal hygiene and the harmful nature of microbes. Yet scientists investigating the rampant immune dysfunction in the developed world have inevitably arrived at this conclusion. To address this global “epidemic of absence,” they must restore the human ecosystem.
This groundbreaking book explores the promising but controversial “worm therapy”—deliberate infection with parasitic worms—in development to treat autoimmune disease. It explains why farmers’ children so rarely get hay fever, why allergy is less prevalent in former Eastern Bloc countries, and how one cancer-causing bacterium may be good for us. It probes the link between autism and a dysfunctional immune system. It investigates the newly apparent fetal origins of allergic disease—that a mother’s inflammatory response imprints on her unborn child, tipping the scales toward allergy. In the future, preventive treatment—something as simple as a probiotic—will necessarily begin before birth.
An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results.
An Epidemic of Absence considers the critical immune stimuli we inadvertently lost as we modernized, and the modern ills we may be able to correct by restoring them. At stake is nothing less than our health, and that of our loved ones. Researchers, meanwhile, have the good fortune of living through a paradigm shift, one of those occasional moments in the progress of science when a radically new way of thinking emerges, shakes things up, and suggests new avenues of treatment. You’ll discover that you’re not you at all, but a bustling collection of organisms, an ecosystem whose preservation and integrity require the utmost attention and care.
Public sanitation and antibiotic drugs have brought about historic increases in the human life span; they have also unintentionally produced new health crises by disrupting the intimate, age-old balance between humans and the microorganisms that inhabit our bodies and our environment. As a result, antibiotic resistance now ranks among the gravest medical problems of modern times. Good Germs, Bad Germs addresses not only this issue but also what has become known as the "hygiene hypothesis"— an argument that links the over-sanitation of modern life to now-epidemic increases in immune and other disorders. In telling the story of what went terribly wrong in our war on germs, Jessica Snyder Sachs explores our emerging understanding of the symbiotic relationship between the human body and its resident microbes—which outnumber its human cells by a factor of nine to one! The book also offers a hopeful look into a future in which antibiotics will be designed and used more wisely, and beyond that, to a day when we may replace antibacterial drugs and cleansers with bacterial ones—each custom-designed for maximum health benefits.
Of all the extraordinary and obscure plants that have been fermented and distilled, a few are dangerous, some are downright bizarre, and one is as ancient as dinosaurs—but each represents a unique cultural contribution to our global drinking traditions and our history.
This fascinating concoction of biology, chemistry, history, etymology, and mixology—with more than fifty drink recipes and growing tips for gardeners—will make you the most popular guest at any cocktail party.
From the Trade Paperback edition.
Horowitz introduces the reader to dogs’ perceptual and cognitive abilities and then draws a picture of what it might be like to be a dog. What’s it like to be able to smell not just every bit of open food in the house but also to smell sadness in humans, or even the passage of time? How does a tiny dog manage to play successfully with a Great Dane? What is it like to hear the bodily vibrations of insects or the hum of a fluorescent light? Why must a person on a bicycle be chased? What’s it like to use your mouth as a hand? In short, what is it like for a dog to experience life from two feet off the ground, amidst the smells of the sidewalk, gazing at our ankles or knees?
Inside of a Dog explains these things and much more. The answers can be surprising—once we set aside our natural inclination to anthropomorphize dogs. Inside of a Dog also contains up-to-the-minute research—on dogs’ detection of disease, the secrets of their tails, and their skill at reading our attention—that Horowitz puts into useful context. Although not a formal training guide, Inside of a Dog has practical application for dog lovers interested in understanding why their dogs do what they do. With a light touch and the weight of science behind her, Alexandra Horowitz examines the animal we think we know best but may actually understand the least. This book is as close as you can get to knowing about dogs without being a dog yourself.
There are thousands of working dogs all over the US and beyond with incredible abilities—they can find missing people, detect drugs and bombs, pinpoint unmarked graves of Civil War soldiers, or even find drowning victims more than two hundred feet below the surface of a lake. These abilities may seem magical or mysterious, but author Cat Warren shows the science, the rigorous training, and the skilled handling that underlie these creatures’ amazing abilities.
Cat Warren is a university professor and journalist who had tried everything she could think of to harness her dog Solo’s boundless energy and enthusiasm…until a behavior coach suggested she try training him to be a “working dog.” What started out as a hobby soon became a calling, as Warren was introduced to the hidden universe of dogs who do this essential work and the handlers who train them.
Her dog Solo has a fine nose and knows how to use it, but he’s only one of many astounding dogs in a varied field. Warren interviews cognitive psychologists, historians, medical examiners, epidemiologists, and forensic anthropologists, as well as the breeders, trainers, and handlers who work with and rely on these intelligent and adaptable animals daily. Along the way, Warren discovers story after story that prove the capabilities—as well as the very real limits—of working dogs and their human partners. Clear-eyed and unsentimental, Warren explains why our partnership with working dogs is woven into the fabric of society, and why we keep finding new uses for the wonderful noses of our four-legged friends.
Anarchy Evolution is a provocative look at the collision between religion and science, by an author with unique authority: UCLA lecturer in Paleontology, and founding member of Bad Religion, Greg Graffin. Alongside science writer Steve Olson (whose Mapping Human History was a National Book Award finalist) Graffin delivers a powerful discussion sure to strike a chord with readers of Richard Dawkins’ The God Delusion or Christopher Hitchens God Is Not Great. Bad Religion die-hards, newer fans won over during the band’s 30th Anniversary Tour, and anyone interested in this increasingly important debate should check out this treatise on science from the god of punk rock.
By venturing out of her clinic and spending time on seven family farms, Miller uncovers all the aspects of farming—from seed choice to soil management—that have a direct and powerful impact on our health. Bridging the traditional divide between agriculture and medicine, Miller shares lessons learned from inspiring farmers and biomedical researchers and artfully weaves their insights and discoveries, along with stories from her patients, into the narrative. The result is a compelling new vision for sustainable healing and a treasure trove of farm-to-body lessons that have immense value in our daily lives.
In Farmacology you will meet:a vegetable farmer in Washington State who shows us how the principles he uses to rejuvenate his soil apply just as well to our own bodies. Here we also discover the direct links between healthy soil and healthy humans. a beef farmer in Missouri who shows how a holistic cattle-grazing method can grow resilient calves and resilient children. an egg farmer in Arkansas who introduces us to the counterintuitive idea that stress can keep us productive and healthy. We discover why the stressors associated with a pasture-based farming system are beneficial to animals and humans while the duress of factory farming can make us ill. a vintner in Sonoma, California, who reveals the principles of Integrated Pest Management and helps us understand how this gentler approach to controlling unwanted bugs and weeds might be used to treat invasive cancers in humans. a farmer in the Bronx who shows us how a network of gardens offers health benefits that extend far beyond the nutrient value of the fruits and vegetables grown in the raised beds. For example, did you know that urban farming can lower the incidence of alcoholism and crime? finally, an aromatic herb farmer in Washington State who teaches us about the secret chemical messages we exchange with plants—messages that can affect our mood and even keep us looking youthful.
In each chapter, Farmacology reveals the surprising ways that the ecology of our body and the ecology of our farms are intimately linked. This is a paradigm-changing adventure that has huge implications for our personal health and the health of the planet.
WHY ADOPT THIS EDITION?
New chapters on:
• Urban Environmental Microbiology
• Bacterial Communities in Natural Ecosystems
• Global Change and Microbial Infectious Disease
• Microorganisms and Bioterrorism
• Extreme Environments (emphasizing the ecology of these environments)
• Aquatic Environments (now devoted to its own chapter- was combined with Extreme Environments)
Updates to Methodologies:
• Nucleic Acid -Based Methods: microarrays, phyloarrays, real-time PCR, metagomics, and comparative genomics
• Physiological Methods: stable isotope fingerprinting and functional genomics and proteomics-based approaches
• Microscopic Techniques: FISH (fluorescent in situ hybridization) and atomic force microscopy
• Cultural Methods: new approaches to enhanced cultivation of environmental bacteria
• Environmental Sample Collection and Processing: added section on air sampling
In The Fever, the journalist Sonia Shah sets out to answer these questions, delivering a timely, inquisitive chronicle of the illness and its influence on human lives. Through the centuries, she finds, we've invested our hopes in a panoply of drugs and technologies, and invariably those hopes have been dashed. From the settling of the New World to the construction of the Panama Canal, through wars and the advances of the Industrial Revolution, Shah tracks malaria's jagged ascent and the tragedies in its wake, revealing a parasite every bit as persistent as the insects that carry it. With distinguished prose and original reporting from Panama, Malawi, Cameroon, India, and elsewhere, The Fever captures the curiously fascinating, devastating history of this long-standing thorn in the side of humanity.
IMAGINE A WORLD WHERE parasites are masters of chemical warfare and camouflage, able to cloak themselves with their hosts' own molecules.
IMAGINE A WORLD WHERE parasites steer the course of evolution, where the majority of species are parasites.
WELCOME TO EARTH.
For centuries, parasites have lived in nightmares, horror stories, and in the darkest shadows of science. Yet these creatures are among the world's most successful and sophisticated organisms. In Parasite Rex, Carl Zimmer deftly balances the scientific and the disgusting as he takes readers on a fantastic voyage. Traveling from the steamy jungles of Costa Rica to the fetid parasite haven of southern Sudan, Zimmer graphically brings to life how parasites can change DNA, rewire the brain, make men more distrustful and women more outgoing, and turn hosts into the living dead.
This thorough, gracefully written book brings parasites out into the open and uncovers what they can teach us about the most fundamental survival tactics in the universe.
Twenty years ago, when John McPhee began his journeys back and forth across the United States, he planned to describe a cross section of North America at about the fortieth parallel and, in the process, come to an understanding not only of the science but of the style of the geologists he traveled with. The structure of the book never changed, but its breadth caused him to complete it in stages, under the overall title Annals of the Former World.
Like the terrain it covers, Annals of the Former World tells a multilayered tale, and the reader may choose one of many paths through it. As clearly and succinctly written as it is profoundly informed, this is our finest popular survey of geology and a masterpiece of modern nonfiction.
Annals of the Former World is the winner of the 1999 Pulitzer Prize for Nonfiction.
Fortunately for you, there's Schaum's Outlines. More than 40 million students have trusted Schaum's to help them succeed in the classroom and on exams. Schaum's is the key to faster learning and higher grades in every subject. Each Outline presents all the essential course information in an easy-to-follow, topic-by-topic format. You also get hundreds of examples, solved problems, and practice exercises to test your skills.
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Schaum's Outlines-Problem Solved.
A Silent Spring for oceans, written by "the Rachel Carson of the fish world" (The New York Times)
Who can forget the sense of wonder with which they discovered the creatures of the deep? In this vibrant hymn to the sea, Callum Roberts—one of the world’s foremost conservation biologists—leads readers on a fascinating tour of mankind’s relationship to the sea, from the earliest traces of water on earth to the oceans as we know them today. In the process, Roberts looks at how the taming of the oceans has shaped human civilization and affected marine life.
We have always been fish eaters, from the dawn of civilization, but in the last twenty years we have transformed the oceans beyond recognition. Putting our exploitation of the seas into historical context, Roberts offers a devastating account of the impact of modern fishing techniques, pollution, and climate change, and reveals what it would take to steer the right course while there is still time. Like Four Fish and The Omnivore’s Dilemma, The Ocean of Life takes a long view to tell a story in which each one of us has a role to play.
Barry Estabrook, author of the New York Times bestseller Tomatoland and a writer of “great skill and compassion” (Eric Schlosser), now explores the dark side of the American pork industry. Drawing on his personal experiences raising pigs as well as his sharp investigative instincts, Estabrook covers the range of the human-porcine experience. He embarks on nocturnal feral pig hunts in Texas. He visits farmers who raise animals in vast confinement barns for Smithfield and Tyson, two of the country’s biggest pork producers. And he describes the threat of infectious disease and the possible contamination of our food supply. Through these stories shines Estabrook’s abiding love for these remarkable creatures. Pigs are social, self-aware, and playful, not to mention smart enough to master the typical house dog commands of “sit, stay, come” twice as fast as your average pooch. With the cognitive abilities of at least three-year-olds, they can even learn to operate a modified computer. Unfortunately for the pigs, they’re also delicious to eat.
Estabrook shows how these creatures are all too often subjected to lives of suffering in confinement and squalor, sustained on a drug-laced diet just long enough to reach slaughter weight, then killed on mechanized disassembly lines. But it doesn’t have to be this way. Pig Tales presents a lively portrait of those farmers who are taking an alternative approach, like one Danish producer that has a far more eco-friendly and humane system of pork production, and new, small family farms with free-range heritage pigs raised on antibiotic-free diets. It is possible to raise pigs responsibly and respectfully in a way that is good for producers, consumers, and some of the top chefs in America.
Provocative, witty, and deeply informed, Pig Tales is bound to spark conversation at dinner tables across America.
Outstanding features: Clearly rendered diagrams and drawings enhance text descriptions; the generous use of tables and charts distill data for easy access and understanding; a 12-page, 4-color section of photos shows various plants with nutrient deficiencies; supplementary reading lists provide a readymade path for readers who want to delve into topics of their own choosing; appendices contain a model law relating to fertilizer materials, useful tables and conversions, and a listing of professional organizations
So she embarked upon the project of learning to hunt from square one. From attending a Hunter Safety course designed for children to field dressing an elk and serving it for dinner, she explores the sport of hunting and all it entails, and tackles the big questions surrounding one of the most misunderstood American practices and pastimes. Not just a personal memoir, this book also explores the role of the hunter in the twenty-first century, the tension (at times artificial) between hunters and environmentalists, and new models of sustainable and ethical food procurement.
Includes New and Updated Material
Now in its second edition, this work is the culmination of research and discussions with technical experts, as well as USP and FDA representatives on various topics of interest to the pharmaceutical microbiologist and those responsible for the microbial quality of products, materials, equipment, and manufacturing facilities. New in this edition is an entire chapter dedicated to the topic of biofilms and their impact on pharmaceutical and biopharmaceutical operations. The subject of rapid methods in microbiology has been expanded and includes a discussion on the validation of alternative microbiological methods and a case study on microbial identification in support of a product contamination investigation.
Substantially updated and revised, this book assists readers in understanding the fundamental issues associated with pharmaceutical microbiology and provides them with tools to create effective microbial contamination control and microbial testing programs for the areas under their responsibility.
As the granddaughter of farmers and the daughter of avid gardeners, Ohlson has long had an appreciation for the soil. A chance conversation with a local chef led her to the crossroads of science, farming, food, and environmentalism and the discovery of the only significant way to remove carbon dioxide from the air--an ecological approach that tends not only to plants and animals but also to the vast population of underground microorganisms that fix carbon in the soil. Ohlson introduces the visionaries--scientists, farmers, ranchers, and landscapers--who are figuring out in the lab and on the ground how to build healthy soil, which solves myriad problems: drought, erosion, air and water pollution, and food quality, as well as climate change. Her discoveries and vivid storytelling will revolutionize the way we think about our food, our landscapes, our plants, and our relationship to Earth.
* Only available work to cover the entire whisky process from raw material to delivery to the market in such a comprehensive manner
* Includes a chapter on marketing and selling whisky
* Foreword written by Alan Rutherford, former Chairman and Managing Director of United Malt and Grain Distillers Ltd.
"Greenberg’s breezy, engaging style weaves history, politics, environmental policy, and marine biology." --New Yorker
In American Catch, award-winning author Paul Greenberg takes the same skills that won him acclaim in Four Fish to uncover the tragic unraveling of the nation’s seafood supply—telling the surprising story of why Americans stopped eating from their own waters.
In 2005, the United States imported five billion pounds of seafood, nearly double what we imported twenty years earlier. Bizarrely, during that same period, our seafood exports quadrupled. American Catch examines New York oysters, Gulf shrimp, and Alaskan salmon to reveal how it came to be that 91 percent of the seafood Americans eat is foreign.
In the 1920s, the average New Yorker ate six hundred local oysters a year. Today, the only edible oysters lie outside city limits. Following the trail of environmental desecration, Greenberg comes to view the New York City oyster as a reminder of what is lost when local waters are not valued as a food source.
Farther south, a different catastrophe threatens another seafood-rich environment. When Greenberg visits the Gulf of Mexico, he arrives expecting to learn of the Deepwater Horizon oil spill’s lingering effects on shrimpers, but instead finds that the more immediate threat to business comes from overseas. Asian-farmed shrimp—cheap, abundant, and a perfect vehicle for the frying and sauces Americans love—have flooded the American market.
Finally, Greenberg visits Bristol Bay, Alaska, home to the biggest wild sockeye salmon run left in the world. A pristine, productive fishery, Bristol Bay is now at great risk: The proposed Pebble Mine project could under¬mine the very spawning grounds that make this great run possible. In his search to discover why this pre¬cious renewable resource isn’t better protected, Green¬berg encounters a shocking truth: the great majority of Alaskan salmon is sent out of the country, much of it to Asia. Sockeye salmon is one of the most nutritionally dense animal proteins on the planet, yet Americans are shipping it abroad.
Despite the challenges, hope abounds. In New York, Greenberg connects an oyster restoration project with a vision for how the bivalves might save the city from rising tides. In the Gulf, shrimpers band together to offer local catch direct to consumers. And in Bristol Bay, fishermen, environmentalists, and local Alaskans gather to roadblock Pebble Mine. With American Catch, Paul Greenberg proposes a way to break the current destructive patterns of consumption and return American catch back to American eaters.
The Washington Post:
"Americans need to eat more American seafood. It’s a point [Greenberg] makes compellingly clear in his new book, American Catch: The Fight for our Local Seafood...Greenberg had at least one convert: me.”
Jane Brody, New York Times
The Los Angeles Times
“If this makes it sound like American Catch is another of those dry, haranguing issue-driven books that you read mostly out of obligation, you needn’t worry. While Greenberg has a firm grasp of the facts, he also has a storyteller’s knack for framing them in an entertaining way.”
The Guardian (UK)
“A wonderful new book”
"This is on the top of my summer reading list. A Fast Food Nation for fish.”
From the Hardcover edition.
In The Viral Storm, award-winning biologist Nathan Wolfe tells the story of how viruses and human beings have evolved side by side through history; how deadly viruses like HIV, swine flu, and bird flu almost wiped us out in the past; and why modern life has made our species vulnerable to the threat of a global pandemic.
Wolfe's research missions to the jungles of Africa and the rain forests of Borneo have earned him the nickname "the Indiana Jones of virus hunters," and here Wolfe takes readers along on his groundbreaking and often dangerous research trips—to reveal the surprising origins of the most deadly diseases and to explain the role that viruses have played in human evolution.
In a world where each new outbreak seems worse than the one before, Wolfe points the way forward, as new technologies are brought to bear in the most remote areas of the world to neutralize these viruses and even harness their power for the good of humanity. His provocative vision of the future will change the way we think about viruses, and perhaps remove a potential threat to humanity's survival.
"Reduce, reuse, recycle" urge environmentalists; in other words, do more with less in order to minimize damage. But as this provocative, visionary book argues, this approach perpetuates a one-way, "cradle to grave" manufacturing model that dates to the Industrial Revolution and casts off as much as 90 percent of the materials it uses as waste, much of it toxic. Why not challenge the notion that human industry must inevitably damage the natural world?
In fact, why not take nature itself as our model? A tree produces thousands of blossoms in order to create another tree, yet we do not consider its abundance wasteful but safe, beautiful, and highly effective; hence, "waste equals food" is the first principle the book sets forth. Products might be designed so that, after their useful life, they provide nourishment for something new-either as "biological nutrients" that safely re-enter the environment or as "technical nutrients" that circulate within closed-loop industrial cycles, without being "downcycled" into low-grade uses (as most "recyclables" now are).
Elaborating their principles from experience (re)designing everything from carpeting to corporate campuses, William McDonough and Michael Braungart make an exciting and viable case for change.
Vaccinated is not a biography; Hilleman's experience forms the basis for a rich and lively narrative of two hundred years of medical history, ranging across the globe and throughout time to take in a cast of hundreds, all caught up, intentionally or otherwise, in the story of vaccines. It is an inspiring and triumphant tale, but one with a cautionary aspect, as vaccines come under assault from people blaming vaccines for autism and worse. Paul Offit clearly and compellingly rebuts those arguments, and, by demonstrating how much the work of Hilleman and others has gained for humanity, shows us how much we have to lose.
If chaos theory transformed our view of the universe, biomimicry is transforming our life on Earth. Biomimicry is innovation inspired by nature – taking advantage of evolution’s 3.8 billion years of R&D since the first bacteria. Biomimics study nature’s best ideas: photosynthesis, brain power, and shells – and adapt them for human use. They are revolutionising how we invent, compute, heal ourselves, harness energy, repair the environment, and feed the world.
Science writer and lecturer Janine Benyus names and explains this phenomenon. She takes us into the lab and out in the field with cutting-edge researchers as they stir vats of proteins to unleash their computing power; analyse how electrons zipping around a leaf cell convert sunlight into fuel in trillionths of a second; discover miracle drugs by watching what chimps eat when they’re sick; study the hardy prairie as a model for low-maintenance agriculture; and more.
Laboratory Animal Medicine, Third Edition,is a fully revised publication from the American College of Laboratory Medicine’s acclaimed blue book series. It presents an up-to-date volume that offers the most thorough coverage of the biology, health, and care of laboratory animals.
The book is organized by species, with new inclusions of chinchillas, birds, and program and employee management, and is written and edited by known experts in the fields.
Users will find gold-standard guidance on the study of laboratory animal science, as well as valuable information that applies across all of the biological and biomedical sciences that work with animals.Organized by species for in-depth understanding of biology, health, and best care of animalsFeatures the inclusion of chinchillas, quail, and zebra finches as animal modelsOffers guidance on program and employee managementCovers regulations, policies, and laws for laboratory animal management worldwide
In April 1982, ethnobotanist Wade Davis arrived in Haiti to investigate two documented cases of zombis—people who had reappeared in Haitian society years after they had been officially declared dead and had been buried. Drawn into a netherworld of rituals and celebrations, Davis penetrated the vodoun mystique deeply enough to place zombification in its proper context within vodoun culture. In the course of his investigation, Davis came to realize that the story of vodoun is the history of Haiti—from the African origins of its people to the successful Haitian independence movement, down to the present day, where vodoun culture is, in effect, the government of Haiti’s countryside.
The Serpent and the Rainbow combines anthropological investigation with a remarkable personal adventure to illuminate and finally explain a phenomenon that has long fascinated Americans.
The core information is presented in a clear and concise way, with extensive use of diagrams, algorithms, tables and boxes. All chapters have been updated to reflect current best practice and the annotated bibliographies and lists of web-based resources have been extended. The chapters on HIV, tuberculosis and malaria have undergone particularly extensive revision, reflecting rapid changes in these areas since the last edition.
Lecture Notes: Tropical Medicine is particularly aimed at postgraduate doctors attending tropical medicine courses, as well as medical students taking a tropical medicine elective period. It will also be useful to a wide range of other health professionals involved with medicine in the tropics, or imported tropical disease.
With The Book of Barely Imagined Beings, Caspar Henderson offers readers a fascinating, beautifully produced modern-day menagerie. But whereas medieval bestiaries were often based on folklore and myth, the creatures that abound in Henderson’s book—from the axolotl to the zebrafish—are, with one exception, very much with us, albeit sometimes in depleted numbers. The Book of Barely Imagined Beings transports readers to a world of real creatures that seem as if they should be made up—that are somehow more astonishing than anything we might have imagined. The yeti crab, for example, uses its furry claws to farm the bacteria on which it feeds. The waterbear, meanwhile, is among nature’s “extreme survivors,” able to withstand a week unprotected in outer space. These and other strange and surprising species invite readers to reflect on what we value—or fail to value—and what we might change.
A powerful combination of wit, cutting-edge natural history, and philosophical meditation, The Book of Barely Imagined Beings is an infectious and inspiring celebration of the sheer ingenuity and variety of life in a time of crisis and change.
• Ants are world-class road builders, handling traffic problems on thoroughfares that dwarf our highway systems in their complexity
• Ants with the largest societies often deploy complicated military tactics
• Some ants have evolved from hunter-gatherers into farmers, domesticating other insects and growing crops for food
This book provides an understanding of the microbial challenges to the safety of low aw foods, and a historic backdrop to the paradigm shift now highlighting low aw foods as vehicles for foodborne pathogens. Up-to-date facts and figures of foodborne illness outbreaks and product recalls are included. Special attention is given to the uncanny ability of Salmonella to persist under dry conditions in food processing plants and foods. A section is dedicated specifically to processing plant investigations, providing practical approaches to determining sources of persistent bacterial strains in the industrial food processing environment. Readers are guided through dry cleaning, wet cleaning and alternatives to processing plant hygiene and sanitation. Separate chapters are devoted to low aw food commodities of interest including spices, dried dairy-based products, low aw meat products, dried ready-to-eat cereal products, powdered infant formula, nuts and nut pastes, flours and meals, chocolate and confectionary, dried teas and herbs, and pet foods. The book provides regulatory testing guidelines and recommendations as well as guidance through methodological and sampling challenges to testing spices and low aw foods for the presence of foodborne pathogens. Chapters also address decontamination processes for low aw foods, including heat, steam, irradiation, microwave, and alternative energy-based treatments.
The vast majority of medically important pathogens infect their host across a body surface such as the skin, or across a mucosal tissue such as the respiratory tract or intestines, as these sites are the ones exposed to the external environment. By focusing on immunity at mucosal and body surfaces this book presents a fresh, new approach to the teaching of immunology.
After an introduction to the basic structure of the immune system, the book looks at two important families of signalling molecules: cytokines and chemokines, before covering the workings of the mucosal immune system. It continues by examining immunity against the four major groups of pathogens - viruses, bacteria, fungi and parasites, and concludes by looking at disorders of the immune system, mucosal tumour immunology and the process of vaccination.A fresh, new approach to the subject focusing on mucosal and body surfaces. Describes the mucosal immune systems of the gastrointestinal, respiratory and urogenital tracts, as well as the skin. Details the important roles of cytokines and chemokines in an immune response. Separate chapters devoted to immunity against viruses, bacteria, fungi and parasites. Includes chapter summaries, boxes with topics of special interest and an extensive glossary. Clearly written and well- illustrated in full colour throughout.
Students across a range of disciplines, including biology, biochemistry, biomedicine, medicine and veterinary sciences, will find this book invaluable, both as an introduction to basic immunology and as a guide to mucosal immune defence mechanisms.
"The most scientifically important dog in over a century." —Brian Hare
Chaser has fascinated dog lovers and scientists alike. Her story reveals the potential for taking out dialogue with dogs well beyond "fetch." When retired psychology professor John Pilley first got his new Border collie puppy, Chaser, he wanted to explore the boundaries of language learning and communication between humans and man's best friend. Exhibiting intelligence previously thought impossible in dogs, Chaser soon learned the names of more than a thousand toys and sentences with multiple elements of grammar. Chaser's accomplishments are revolutionizing the way we think about the intelligence of animals. John and Chaser's inspiring journey demonstrates the power of learning through play and opens our eyes to the boundless potential in the animals we love.
This book is written in the same engaging conversational style as the published reference book The Immune Response: Basic and Clinical Principles and conveys the same fascinating appeal of immunology. The authors bring clarity, readability and continuity of voice to an audience that requires only a brief survey of the most fundamental concepts in basic and clinical immunology. Primer to The Immune Response is beautifully illustrated with over 200 superb figures and 36 full-color plates, and further enhanced by the inclusion of 60 tables and 6 Appendices. Included with purchase of the book is website access to a captivating “Immunomovie" that truly brings the immune response to pathogens to life. This new and unique immunology textbook compactly but elegantly covers both basic and clinical principles.Over 200 elegant 2-4 color illustrations36 full-color plates of basic and clinical items of interestTake-home message and “Did You Get It? self-test quiz at the end of each chapter6 Appendices that provide topic enrichment60-minute "Immunomovie" illustrating the immune response to bacterial, viral and parasitic infections
Microorganisms in Foods 5, 7, and the second edition of Microorganisms in Foods 6 are for anyone using microbiological testing and/or engaged in setting Microbiological Criteria, whether for the purpose of Governmental Food Inspection and Control or in Industry, and for those identifying the most effective use of microbiological testing in the food chain. The contents are essential reading for food processors, food microbiologists, food technologists, veterinarians, public health workers and regulatory officials. For students in Food Science and Technology they offer a wealth of information on Food Microbiology and Food Safety Management, with many references for further study.
The information has been prepared by the International Commission on Microbiological Specifications for Foods (ICMSF). The ICMSF was formed in response to the need for internationally acceptable and authoritative decisions on microbiological limits for foods moving in international commerce. Currently the membership consists of eighteen food microbiologists from eleven countries, drawn from governmental laboratories in public health, agriculture, and food technology, from universities and from the food industry.
"A very well-written book suitable for use as a reference or textbook for an undergraduate subject in cell signalling. For researchers interested in the molecular basis of cell signalling and how aberrant regulation of cell signalling proteins causes diseases, this is an excellent resource of biochemical and structural information." –Australian Biochemist, August 2009
"From basics to details, this is an elegantly written and carefully edited book. The chapters on cell cycle control and oncogenesis are particularly fascinating and valuable to biomedical research. This is the book to have if you are interested in molecular mechanisms of signal transduction. It is a great introduction to the literature that will be welcomed by students and experts alike." –Doody's, January 2009
This text is a concise and accessible introduction to the dynamic but complex field of signal transduction. Rather than simply cataloguing all signalling molecules and delineating every known pathway, this book aims to break signalling down into common elements and activities – the ‘nuts and bolts’ of cellular information exchange.
With an emphasis on clarity of presentation throughout, the book teaches the basic principles focusing on a mature core of knowledge, providing students with a foundation of learning in this complex and potentially confusing subject. It also addresses the issue of variation in the numbering of key amino acids as well as featuring interaction with RasMol software, and exercises to aid understanding.An accessible introduction to the complex field of cell signalling Interacts with RasMol software – freely downloadable for viewing structures in 3D Includes exercises and clear instructions in the use of RasMol Well illustrated in full colour throughout
Structure and Function in Cell Signalling is an invaluable resource to students across a range of life science degree programmes including biochemistry, cell and molecular biology, physiology, biomedicine and oncology. This book provides a clear, accessible introduction to this rapidly expanding field.
Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.Completely updated, the 2e presents recent advances driven by new information on the genetics and genomics of the pathogenProvides the latest information concerning the epidemiology, diagnosis, treatment and prevention of toxoplasmosisOffers a single-source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians, and food scientists
Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitroCovers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodiesColor illustrations enhance explanations of the immune system
On the afternoon of August 20, 1910, a battering ram of wind moved through the drought-stricken national forests of Washington, Idaho, and Montana, whipping the hundreds of small blazes burning across the forest floor into a roaring inferno that jumped from treetop to ridge as it raged, destroying towns and timber in the blink of an eye. Forest rangers had assembled nearly ten thousand men to fight the fires, but no living person had seen anything like those flames, and neither the rangers nor anyone else knew how to subdue them. Egan recreates the struggles of the overmatched rangers against the implacable fire with unstoppable dramatic force, and the larger story of outsized president Teddy Roosevelt and his chief forester, Gifford Pinchot, that follows is equally resonant. Pioneering the notion of conservation, Roosevelt and Pinchot did nothing less than create the idea of public land as our national treasure, owned by every citizen. Even as TR's national forests were smoldering they were saved: The heroism shown by his rangers turned public opinion permanently in favor of the forests, though it changed the mission of the forest service in ways we can still witness today.
This e-book includes a sample chapter of SHORT NIGHTS OF THE SHADOW CATCHER.