Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteasome system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects.
In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group.
Key features include:
• Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups.
• How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism.
• Numerous examples and expanded discussions for complex concepts.
• Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice.
• An overview of structure activity relationships (SARs) and concepts that govern drug design.
• Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix.
Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry.
About the Authors
Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy.
Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.
Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues.
Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms is a compilation of review articles devoted to the study on the topic with respect to biochemical and molecular mechanisms of hyperglycaemia. The wide range of areas covered here is of interest to basic research scientists, clinicians and graduate students, who are devoted to study the pathogenesis of diabetes-induced cardiovascular dysfunction. Furthermore, some chapters are directed towards increasing our understanding of novel ways for the prevention/treatment of cardiomyopathy.
Twenty five articles in this book are organized in three sections. The first section discusses general aspects of the metabolic derangements in diabetic cardiomyopathy including metabolic alterations and substrate utilization as well as cardiac remodelling in the heart; role of diet in the development of metabolic syndrome in the heart; effect of hyperglycaemia in terms of biochemical and structural alterations in heart. In the second section, several cellular and molecular mechanisms are discussed indicating that diabetic cardiomyopathy is a multifactorial and complex problem. The third section discusses the prevention and treatment of diabetes using appropriate diet, proper supplements including antioxidants, angiotensin inhibitors and some other drugs. All in all, this book discusses the diverse mechanisms of diabetic cardiomyopathy with some information on new therapeutic approaches for finding solutions to prevent or reverse the development of cardiac dysfunction.
Too little salt in the diet can shift the body into semi-starvation mode and cause insulin resistance, and may even cause you to absorb twice as much fat for every gram you consume. Too little salt in certain populations can actually increase blood pressure, as well as resting heart rate. We need salt in order to hydrate and nourish our cells, transmit nerve signals, contract our muscles, ensure proper digestion and breathing, and maintain proper heart function. The Salt Fix will show how we wrongly demonized this essential micronutrient as well as explain what the current science really says about this misunderstood mineral and how to maximize its effect so you can enjoy ideal health and longevity.
Included are practice exams for the following domains:
• Pharmacy Law and Regulations
• Sterile and Non-Sterile Compounding
• Medication Safety
• Pharmacy Quality Assurance
• Medication Order Entry and Fill Process
• Pharmacy Inventory Management
• Pharmacy Billing and Reimbursement
• Pharmacy Information Usage and Application
This innovative workbook includes:
• 100 pharmaceutical calculation questions including ratios and conversions, dimensional analysis, alligation, measurements for accurate drug doses, and business math
• Formulas to master the essential math you'll face on the exam
• Five separate 100 question comprehensive practice exams
• Detailed solutions to all practice questions to help you pinpoint your strengths and weaknesses and identify areas in need of further study
Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.
Updated Second Edition
500 Questions & Answers You Need to Know
This latest addition to our Health Sciences series of flashcards is designed to help PTCE candidates check their test-readiness before taking the Pharmacy Technician Certification Exam. Unlike most flashcards that come in a box, our cards are bound in an easy-to-use, organized book that makes it convenient to study anywhere.
Written by a seasoned pharmacy technician instructor and based on the most recent exam, our study supplement covers everything you need to know for the PTCE: assisting the pharmacist in serving patients, maintaining medication and inventory control systems, and participating in the management of pharmacy practice.
The flashcards are broken down by PTCE test topics and include multiple-choice questions with detailed answer explanations. The questions are similar to what you may encounter on the PTCE. The 500 flashcards are divided as follows:
* 200 flashcards focused on the top 200 brand/generic drug names including their respective drug classes, indications, side effects, and special considerations
* 50 flashcards focused on pharmaceutical terms and abbreviations
* 250 flashcards focused on PTCE review material:
- 165 flashcards on Assisting the Pharmacist in Serving Patients
- 55 flashcards on Maintaining Medication and Inventory Control Systems
- 30 flashcards on Participating in the Administration and Management of Pharmacy Practice
After studying with the book, go online and review what you have learned at REA's Study Center. Our customizable e-flashcards and 3 practice quizzes give you the freedom to create your own PTCE study plan and study anywhere, anytime. You can also create your own unique flashcards for any sections of the test that give you difficulty.
This flashcard book and the online tools that come with it, will help you personalize your PTCE prep by testing your understanding, pinpointing your weaknesses, and delivering flashcard study materials unique to you.
If you're a pharmacy tech student and want extra practice and review before the exam, REA's PTCE Flashcard Book is the right Rx for your study needs.
Includes thorough reviews of all major body systems, with an emphasis on system interaction, homeostasis, and pathophysiology.Designed as a companion to the 13th edition of Guyton and Hall Textbook of Medical Physiology, highlighting essential key concepts and featuring direct page references to specific questions.Provides essential information needed to prepare for the physiology portion of the USMLE Step 1.
Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development.
Pretests in each chapter allow readers to assess their current knowledge of specific topics.
Step-by-step examples make it easy to learn and remember how to do equations and use formulas.
Hundreds of practice problems provide practice with calculations, conversions, and measurements.
Actual drug labels accompany examples and problems, for real-world experience with the information you will see in pharmacy practice.
Business Math for Pharmacy Technicians chapter introduces the calculations needed in retail pharmacy settings.
Body system icons appear next to medication names to help you associate different drugs with their respective disorders and body systems.
Points to Remember boxes make it easy to learn and remember key information.
Review of Rules sections in each chapter summarize the rules and methods for performing equations.
Chapter reviews provide a quick summary of the key concepts in each chapter.
Posttests in each chapter allow you to assess how well you have learned the material.
A comprehensive posttest includes 50 questions that assess your knowledge of all major topics covered in the book.
Helpful study tools also include an answer key for odd-numbered problems and a comprehensive glossary.Updated content meets ASHP requirements and features new topics such as powder volume and compounding problems, formulas for reducing and enlarging medications, and opportunities to write out prescription label directions.
Tech Note boxes offer helpful advice on real-life situations you may encounter in the pharmacy.
Tech Alert boxes warn against common pharmacy and medication errors that could impact patients' safety.
Additional prescription and practice exercises give you valuable experience with translating physician directions into patient instructions.
Tricky concepts are illustrated and explained with clarity and precision, as The Human Brain Book looks at how the brain sends messages to the rest of the body, how we think and feel, how we perform unconscious actions (for example, breathing), explores the nature of genius, asks why we behave the way we do, explains how we see and hear things, and how and why we dream. Physical and psychological disorders affecting the brain and nervous system are clearly illustrated and summarized in easy-to-understand terms.
Heart Function in Health and Disease has been organized in five sections to provide an outline of a complex problem in a convenient manner. One section of this book is devoted to shedding light on the restructuring and ontogenic changes in the developing heart whereas in the next section some hypertrophic alterations due to chronic hypoxia are described. The third and fourth sections of this book are concerned with the regulation of cardiac channels as well as signal transduction mechanisms and cardiac electric field. The fifth section contains some pathophysiological events during the development of cardiac hypertrophy and heart failure. All of these areas encompass a significant body of new information that will be invaluable to those who work in the field of cardiovascular sciences, as well as those who treat people with heart disease.
A Doody's Core Title for 2017!
Pharmacotherapy Handbook provides the critical information you need to make drug therapy decisions for more than 140 diseases and disorders commonly encountered in a clinical setting. Featuring a convenient alphabetized presentation, this handy guide utilizes text, tables, figures, and treatment algorithms to make important drug data readily accessible and easily understood.
Features:Consistent chapter organization includes: Disease state definition Concise review of relevant pathophysiology Clinical presentation Diagnosis Goals of treatment Treatment Monitoring Six appendices, including "Allergic and Pseudoallergic Drug Reactions" and "Geriatrics" The ideal companion to Pharmacotherapy: A Pathophysiologic Approach, Ninth Edition by Joseph DiPiro, et al
Illustrated by more than 1000 clear line diagrams
Complemented with numerous tables and flowcharts for quick comprehension
Text and figures in an attractive four colour format
A balanced amalgamation of pure and applied text
Highlights applied aspects of physiology in separate boxes
Systematic organization of text to facilitate easy review
Integrates equations and sample problems throughout the text.
Presents chapter summaries for quick overviews of important points.
Contains boxed Clinical Physiology Cases to provide you with more clinical examples and a more thorough understanding of application.
Provides questions at the end of each chapter for an extensive review of the material and to reinforce your understanding and retention.
Offers a full-color design and all full-color illustrations throughout.Features increased coverage of pathophysiology in the neurophysiology, gastrointestinal, renal, acid-base, and endocrine chapters to emphasize this important component of the USMLE exam.
Incorporates further practice in solving physiology equations through the inclusion of additional problem-solving questions throughout the text.
From Abilify to Zyrtec and nearly every drug in between, Mosby's Drug Reference for Health Professions, 3rd Edition is the must-have item for every aspiring health professional. In fact, it's the only drug book on the market written specifically for health professionals! Filled with vital details your students need to know about patient medications, this updated edition features concise, reliable information that is easy to navigate and simple to follow. Key details are presented in short monographs for 1,000 generic drugs (including 4,500 trade-name drugs) that are listed alphabetically. Precautions and considerations sections are tailored to circumstances your students will face on the job. Make certain they have the most relevant information on hand for their studies and for clinical practice with Mosby's Drug Reference for Health Professions, 3rd Edition!
Watch a Fox News segment on The Longevity Project.
This landmark study--which Dr. Andrew Weil calls "a remarkable achievement with surprising conclusions"--upends the advice we have been told about how to live to a healthy old age.
We have been told that the key to longevity involves obsessing over what we eat, how much we stress, and how fast we run. Based on the most extensive study of longevity ever conducted, The Longevity Project exposes what really impacts our lifespan-including friends, family, personality, and work.
Gathering new information and using modern statistics to study participants across eight decades, Dr. Howard Friedman and Dr. Leslie Martin bust myths about achieving health and long life. For example, people do not die from working long hours at a challenging job- many who worked the hardest lived the longest. Getting and staying married is not the magic ticket to long life, especially if you're a woman. And it's not the happy-go-lucky ones who thrive-it's the prudent and persistent who flourish through the years.
With questionnaires that help you determine where you are heading on the longevity spectrum and advice about how to stay healthy, this book changes the conversation about living a long, healthy life.
Developed by Robin M. Zavod and Marc W. Harrold, authors of the highly praised textbook, Basic Concepts in Medicinal Chemistry, this Self Assessment is the only publication of its kind. A highly engaging way for pharmacy and pre-health students to master the complexities of medicinal chemistry, it reinforces what they learn in class with practice problems and review questions which are answered at the end of the book.
The Self Assessment book and its related online content are also handy teaching tools, as well as a source of new problem formats and strategies for exploring concepts from different perspectives.
Zavod and Harrold’s approach provides a clear translation of organic chemistry concepts into medicinal chemistry language, and includes numerous clinically relevant examples, relating medicinal chemistry to therapeutic decisions. A valuable enhancement to any medicinal chemistry text, this book will also be very helpful for students learning organic or biochemistry, as well as for practitioners who want to renew their understanding of medicinal chemistry.
This book is based on two international Mendel symposia on “Genes and the Heart,” joint meetings of the Japanese and European sections of the International Academy of Cardiovascular Sciences. Highlighting selected symposia contributions, this book explores the role of molecular biology and genetics in the basic knowledge, genesis, and clinical interventions of cardiovascular diseases.
This book is clearly written, accurate, and easy to understand. It can be used in a classroom setting or for independent study to develop a careful and systematic approach to pharmacy calculations and can be used as a study aid for the PTCE and ExCPT exams.
A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology. It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies.
For more than four decades, Ganong’s Review of Medical Physiology has been helping those in the medical field understand human and mammalian physiology. Applauded for its interesting and engagingly written style, Ganong’s concisely covers every important topic without sacrificing depth or readability and delivers more detailed, high-yield information per page than any other similar text or review.
Thoroughly updated to reflect the latest research and developments in important areas. Ganong’s Review of Medical Physiology incorporates examples from clinical medicine to illustrate important physiologic concepts.More than 600 full-color illustrations Two types of review questions: end-of-chapter and board-style NEW! Increased number of clinical cases and flow charts
TechPrep™ contains more than 1,000 review questions to help readers prepare for national technician certification exams. A robust Practice Session feature allows users to create custom quizzes by setting topic area, time, and number of questions. The Simulated Exam function lets readers practice their test skills by providing a 90 question, 120 minute test, with questions weighted to mimic national certification exams. Students using TechPrep™ receive instant, automated scoring, and can quickly identify areas they’ve mastered, or practice subjects where they need improvement. Alone or with the new edition of the Manual for Pharmacy Technicians, 4th Edition andall-new Workbook for the Manual for Pharmacy Technicians, the Pharmacy Technician Review Guide and Practice Exam offers the most comprehensive review to help you achieve certification!
This volume is a compendium of different approaches to understanding cardiovascular disease and identifying the proteins, pathways and processes that impact it.
Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before.
In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extension—even age reversal—has moved from science fiction to real possibility.
Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging.
Twenty years ago, there was still considerable debate of the nature of human aging, with a variety of competing theories in play. But scientific consensus is forming around the telomere theory of aging. The essence of this theory is that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres (the tips of the chromosomes) shorten. With every shortening of the telomeres, the cell’s ability to repair its molecules decreases. It ages. Human aging is the result of the aging of the body’s trillions of cells.
But some of our cells don’t age. Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. Telomerase re-lengthens the telomeres, keeping these cells young.
The Telomerase Revolution describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to dramatically extend life spans and even reverse human aging. Telomerase-based treatments are already available, and have shown early promise, but much more potent treatments will become available over the next decade.
The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.
We all have a rage circuit we can’t fully control once it is engaged as R. Douglas Fields, PhD, reveals in this essential book for our time. The daily headlines are filled with examples of otherwise rational people with no history of violence or mental illness suddenly snapping in a domestic dispute, an altercation with police, or road rage attack. We all wish to believe that we are in control of our actions, but the fact is, in certain circumstances we are not. The sad truth is that the right trigger in the right circumstance can unleash a fit of rage in almost anyone.
But there is a twist: Essentially the same pathway in the brain that can result in a violent outburst can also enable us to act heroically and altruistically before our conscious brain knows what we are doing. Think of the stranger who dives into a frigid winter lake to save a drowning child.
Dr. Fields is an internationally recognized neurobiologist and authority on the brain and the cellular mechanisms of memory. He has spent years trying to understand the biological basis of rage and anomalous violence, and he has concluded that our culture’s understanding of the problem is based on an erroneous assumption: that rage attacks are the product of morally or mentally defective individuals, rather than a capacity that we all possess.
Fields shows that violent behavior is the result of the clash between our evolutionary hardwiring and triggers in our contemporary world. Our personal space is more crowded than ever, we get less sleep, and we just aren't as fit as our ancestors. We need to understand how the hardwiring works and how to recognize the nine triggers. With a totally new perspective, engaging narrative, and practical advice, Why We Snap uncovers the biological roots of the rage response and how we can protect ourselves—and others.
From the Hardcover edition.