Chairman: Dennis Murphy, 1986
Depression is a common and often debilitating affective disorder. Attempts to develop effective antidepressants have a long history, but many questions remain about the mechanisms of action of such treatments and about the aetiology and pathophysiology of depression itself. Early observations centred attention on central monoamine systems, and animal studies suggested that changes in beta-adrenoceptor responsiveness were a common effect of antidepressant therapies. More recent research has encompassed many different central and peripheral receptors, time-dependent adaptational events at synapses, and the functional significance of changes in neurotransmitter systems in both humans and experimental animals. Such pharmacological studies aimed ultimately at elucidating the neurochemical basis of depression and of promoting new therapeutic approaches, provide the focus of this symposium volume. Many different methods of investigating the links between monoamine systems, depression and antidepressant treatments are described. Recent studies of receptors and of monoamine uptake sites in the brain and the periphery (e.g. in platelets and fibroblasts) are reviewed, with emphasis on alpha and beta adrenoceptors, [3H]imipramine-binding sites and serotonin receptors. The results of monitoring amine metabolites in cerebrospinal fluid and of measuring neuroendocrine, physiological and behavioural responses to pharmacological challenge are presented, providing information on monoaminergic function in depressed patients and experimental animals before, during and after treatment with antidepressant drugs or electroconvulsive shock. Genetic influences on receptor density are also discussed, as is the relevance to human depressive illness of animal models, including stress-induced behavioural depression in rats and responses to social stressors in rhesus monkeys.
This book should be of interest to neuropharmacologists, psychopharmacologists, clinical pharmacologists, behavioural scientists, psychiatrists and neuroscientists.
Chairman: Stuart B. Levy, 1997
Over the last 50 years, the rapid increase in the use of antibiotics, not only in people, but also in animal husbandry and agriculture, has delivered a selection unprecedented in the history of evolution. Consequently, society is facing one of its gravest public health problems-the emergence of infectious bacteria with resistance to many, and in some cases all, available antibiotics. This book brings together a multidisciplinary group of experts to discuss this problem. It begins by examining the origins of resistance and goes on to look at how the use of antibiotics in human medicine and farming/agriculture has selected for resistant bacteria. Separate chapters describe the evolution of resistance determinants and how these are spread both within and between bacterial species. Finally, the book contains discussions on strategies for countering the threat of antibiotic resistance. A major re-thinking of our approach to the treatment of infectious diseases is proposed-that antibiotic resistance should be seen as a problem created by the disruption of normal microbial ecology. To restore efficacy to earlier antibiotics, and to maintain the success of new antibiotics that are introduced, we need to use these drugs in a way that ensures an ecological balance that favours the predominance of susceptible bacteria.
Debilitating brain disorders are on the rise-from children diagnosed with autism and ADHD to adults developing dementia at younger ages than ever before. But a medical revolution is underway that can solve this problem: Astonishing new research is revealing that the health of your brain is, to an extraordinary degree, dictated by the state of your microbiome - the vast population of organisms that live in your body and outnumber your own cells ten to one. What's taking place in your intestines today is determining your risk for any number of brain-related conditions.
In BRAIN MAKER, Dr. Perlmutter explains the potent interplay between intestinal microbes and the brain, describing how the microbiome develops from birth and evolves based on lifestyle choices, how it can become "sick," and how nurturing gut health through a few easy strategies can alter your brain's destiny for the better. With simple dietary recommendations and a highly practical program of six steps to improving gut ecology, BRAIN MAKER opens the door to unprecedented brain health potential.
900 full-color illustrations
Principles of Neural Science, 5e describes our current understanding of how the nerves, brain, and mind function. From molecules to anatomic structures and systems to cognitive function, this comprehensive reference covers all aspects of neuroscience. Widely regarded as the field’s cornerstone reference, the fifth edition is highlighted by more than 900 full-color illustrations. The fifth edition has been completely updated to reflect the tremendous amount of new research and development in neuroscience in the last decade. Lead author Eric Kandel was awarded the Nobel Prize in Physiology or Medicine in 2000.
With a traumatic brain injury (TBI) occurring every 18.5 seconds in this country - concussions the most common - chances are you have been touched in some way by this experience. TBIs occur due to accidents and sports, and are also common in returning soldiers. The personal stories in this book, by TBI survivors and those who love and support them, will help and encourage you and your family on your road to recovery.
In The Migraine Miracle, a neurologist with a personal history of migraines offers readers the revolutionary dietary cure that has worked for him and continues to work for his patients: a diet low in wheat, sugar, and processed foods, and high in organic, protein-rich animal products. The book also explores the link between inflammation, diet, and migraines, and contains a 21-day meal plan to help readers change the way they eat. By following this easy meal plan, millions of sufferers will discover a life free from symptoms—once and for all.
The book includes comprehensive, research-based information that explains what the brain goes through during a migraine headache, the phases of the migraine, and how a diagnosis is made. It also explores the risks and benefits of migraine medication, natural remedies for migraines, dietary migraine triggers, and detailed, specific instructions for a migraine-free eating plan.
If you have tried migraine medicine but have not found real relief, it’s time to try something new. By changing the way you eat, and understanding what foods can trigger your migraine, you can start feeling better longer, without the threat of a migraine always looming over everything you do.
The goal of neurological critical care is to rapidly deliver acute medical therapies and appropriate interventions through effective monitoring of both neurological and end organ function. The NeuroICU Book puts that goal within the reach of every neurologist and critical care specialist.
Combining the latest clinical perspectives in critical care medicine, neurology, and neurosurgery, this comprehensive, evidence-based text standardizes neurocritical care and takes you through the rationale for those standards. Filled with detailed case studies and featuring a question-and-answer format, the book not only builds competency in recognizing acute changes in neurological function, but also addresses all organ insufficiencies and failures, reflecting the real-life challenges in the modern neuro-ICU.
FEATURESRobust, wide-ranging scope goes beyond classic neurology to encompass other organ failures at the time of presentation or during the ICU stay Evidence-based approach leverages the scientific and controlled research that supports the key treatment methods outlined in the book Balanced coverage of neuro care and critical care offers outstanding preparation for the neurocritical care board certification exam as well as an indispensible primer for daily clinical work in critical care medicine Cutting-edge insights into the care used in some of the more advanced neuroICUs provides a crucial blueprint for understanding the newer procedures and protocols Practical tools including algorithms, tables, illustration, photographs, detailed references, and critical take-home points