Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years.
The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist.
From the Persian Queen Atossa, whose Greek slave may have cut off her diseased breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease.
Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
A New York Times Notable Book
A Washington Post and Seattle Times Best Book of the Year
From the Pulitzer Prize-winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle).
“Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.
“Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome.
“A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).
Taking on prominent thinkers who argue that music is nothing more than an evolutionary accident, Levitin poses that music is fundamental to our species, perhaps even more so than language. Drawing on the latest research and on musical examples ranging from Mozart to Duke Ellington to Van Halen, he reveals:
• How composers produce some of the most pleasurable effects of listening to music by exploiting the way our brains make sense of the world
• Why we are so emotionally attached to the music we listened to as teenagers, whether it was Fleetwood Mac, U2, or Dr. Dre
• That practice, rather than talent, is the driving force behind musical expertise
• How those insidious little jingles (called earworms) get stuck in our head
A Los Angeles Times Book Award finalist, This Is Your Brain on Music will attract readers of Oliver Sacks and David Byrne, as it is an unprecedented, eye-opening investigation into an obsession at the heart of human nature.
This book is an invaluable resource for burgeoning audio engineers. With clear writing and comprehensive illustrations, fundamental concepts of acoustics are explained in easy to understand language. The operating principles of the essential components of a sound system, as well as their use in the design and implementation of the system, are covered in detail. Operational aspects of executing a live performance are also given full treatment.
By providing practical information surrounding the concepts, implementations, and practices central to live sound reinforcement, this book sets the foundation upon which to build and move forward with confidence.
This is the first in a series of digital audio-engineering books written by Wick van den Belt, who used to be head-lecturer on various audio engineering courses.
From the author of How the Universe Got Its Spots and A Madman Dreams of Turing Machines, the epic story of the scientific campaign to record the soundtrack of our universe.
Black holes are dark. That is their essence. When black holes collide, they will do so unilluminated. Yet the black hole collision is an event more powerful than any since the origin of the universe. The profusion of energy will emanate as waves in the shape of spacetime: gravitational waves. No telescope will ever record the event; instead, the only evidence would be the sound of spacetime ringing. In 1916, Einstein predicted the existence of gravitational waves, his top priority after he proposed his theory of curved spacetime. One century later, we are recording the first sounds from space, the soundtrack to accompany astronomy’s silent movie.
In Black Hole Blues and Other Songs from Outer Space, Janna Levin recounts the fascinating story of the obsessions, the aspirations, and the trials of the scientists who embarked on an arduous, fifty-year endeavor to capture these elusive waves. An experimental ambition that began as an amusing thought experiment, a mad idea, became the object of fixation for the original architects—Rai Weiss, Kip Thorne, and Ron Drever. Striving to make the ambition a reality, the original three gradually accumulated an international team of hundreds. As this book was written, two massive instruments of remarkably delicate sensitivity were brought to advanced capability. As the book draws to a close, five decades after the experimental ambition began, the team races to intercept a wisp of a sound with two colossal machines, hoping to succeed in time for the centenary of Einstein’s most radical idea. Janna Levin’s absorbing account of the surprises, disappointments, achievements, and risks in this unfolding story offers a portrait of modern science that is unlike anything we’ve seen before.
From the Hardcover edition.
Serving both as a text for students in engineering departments and as a reference for practicing engineers, this book focuses on electroacoustics, analyzing the behavior of transducers with the aid of electro-mechano-acoustical circuits. Assuming knowledge of electrical circuit theory, it starts by guiding readers through the basics of sound fields, the laws governing sound generation, radiation, and propagation, and general terminology. It then moves on to examine:Microphones (electrostatic and electromagnetic), electrodynamic loudspeakers, earphones, and hornsLoudspeaker enclosures, baffles, and waveguidesMiniature applications (e.g., MEMS in I-Pods and cellphones)Sound in enclosures of all sizes, such as school rooms, offices, auditoriums, and living rooms
Numerical examples and summary charts are given throughout the text to make the material easily applicable to practical design. It is a valuable resource for experimenters, acoustical consultants, and to those who anticipate being engineering designers of audio equipment.An update for the digital age of Leo Beranek's classic 1954 book AcousticsProvides detailed acoustic fundamentals, enabling better understanding of complex design parameters, measurement methods, and dataExtensive appendices cover frequency-response shapes for loudspeakers, mathematical formulas, and conversion factors
Dr. Olson discusses the nature of sound waves; explains the division of sound into scale patterns and the traditional method of notating them; describes the individual characteristics of all musical instruments currently in use (including the human voice); shows how the ears hear; discusses concert hall and recording studio acoustics, amplification systems, etc; describes the elements of sound reproduction systems from the telephone to the stereo record player; and concludes with a new chapter on the production, development, and potentialities of electronic music.
Under these broad headings, readers will find a close analysis of the way in which a violin produces sound; descriptions of carbon, crystal, dynamic, velocity, and unidirectional microphones; a comparison of the relative absorbency of 22 acoustic materials, building materials, and objects; a description of how music can be produced by a digital computer; and much, much more. Conductors will find suggestions on positioning their orchestras; performers will understand the dynamics of their instruments; recording engineers and acousticians will discover a remarkably comprehensive reference work; and music teachers, students, physicists, and enthusiasts in general will find easy access to a vast wealth of information.
A unified account of the field rather than a description of parallel methods, the text's main thematic approaches include the self-consistent field and its generalizations, perturbation theory and the use of Feynman diagrams, and the use of Green functions to describe excitations of a many-body system. The primary emphasis is on the theories of atomic nuclei, the electron gas, superconductivity, and liquid helium three. A familiarity with the principles of nonrelativistic quantum mechanics and statistical mechanics is assumed, but a detailed knowledge of nuclear and solid state physics is unnecessary.
For centuries, mariners have spun tales of gargantuan waves, 100-feet high or taller. Until recently scientists dismissed these stories—waves that high would seem to violate the laws of physics. But in the past few decades, as a startling number of ships vanished and new evidence has emerged, oceanographers realized something scary was brewing in the planet’s waters. They found their proof in February 2000, when a British research vessel was trapped in a vortex of impossibly mammoth waves in the North Sea—including several that approached 100 feet.
As scientists scramble to understand this phenomenon, others view the giant waves as the ultimate challenge. These are extreme surfers who fly around the world trying to ride the ocean’s most destructive monsters. The pioneer of extreme surfing is the legendary Laird Hamilton, who, with a group of friends in Hawaii, figured out how to board suicidally large waves of 70 and 80 feet. Casey follows this unique tribe of people as they seek to conquer the holy grail of their sport, a 100-foot wave.
In this mesmerizing account, the exploits of Hamilton and his fellow surfers are juxtaposed against scientists’ urgent efforts to understand the destructive powers of waves—from the tsunami that wiped out 250,000 people in the Pacific in 2004 to the 1,740-foot-wave that recently leveled part of the Alaskan coast.
Like Jon Krakauer’s Into Thin Air, The Wave brilliantly portrays human beings confronting nature at its most ferocious.
This is an ideal reference for professionals in the public and private power service sectors such as engineers, lawyers, systems specialists, economists, financial analysts, policy analysts, and applied mathematicians.
In their conversations with the justices, Brian Lamb and Susan Swain bring readers into a fascinating world to which few have had access. Chief Justice John Roberts talks about the role of the Court in society, his role as chief justice, and the process of deciding cases. Justice Stephen Breyer takes us on a private tour of his chambers and describes the differences between the Court and the Congress. And new Justices Sonia Sotomayor and Elena Kagan reflect on their first impressions of the job. Through these encounters, the justices’ personalities, intellects, and devotion to the Court emerge.
Enriching this material are Mark Farkas’s interviews with journalists, court historians, and other experts on the Court. Reporters Joan Biskupic and Lyle Denniston discuss the Supreme Court in action and the impact of a new member of the Court. Clerk of the Supreme Court William Suter illuminates the traditions of the Court. Historian James O’Hara discusses the Supreme Court building and its history. Former Solicitor General Drew Days III and attorney Maureen Mahoney describe the experience of facing the justices in fast-paced oral arguments.
The Supreme Court offers readers a rare window into the nation’s highest court through the eyes of those who serve there. It is absorbing reading for anyone interested in this vital and powerful institution.
Witches, Midwives, and Nurses, first published by the Feminist Press in 1973, is an essential book about the corruption of the medical establishment and its historic roots in witch hunters. In this new edition, Barbara Ehrenreich and Deirdre English have written an entirely new chapter that delves into the current fascination with and controversies about witches, exposing our fears and fantasies. They build on their classic exposé on the demonization of women healers and the political and economic monopolization of medicine. This quick history brings us up-to-date, exploring today's changing attitudes toward childbirth, alternative medicine, and modern-day witches.
Addressing questions most ocean visitors have had and offering new ones for our consideration, The Science of Ocean Waves explains in accessible language how waves are formed, how they move, how they become huge and destructive, and how they're being studied now for clues that will help us plan for the future.
Devoting chapters to wind, tides, currents, breakers, tsunamis, forecasting, renewable energy, and El Niño—as well as discussing the gentler properties of ocean waves which inspire us and offer opportunities for relaxation and recreation—Zirker explores the physical factors that create waves.
Drawing on some of the recent storms that have devastated entire regions—such as Hurricane Katrina, the tsunami launched by the 2004 Sumatran earthquake, and the great tsunami that crushed the shore of Japan in 2011—Zirker explains the forces that cause these monster waves and reveals the toll they take on human lives.
Enhanced by dozens of illustrations and a comprehensive glossary, The Science of Ocean Waves will fascinate anyone curious about the science behind the headlines.
Praise for J. B. Zirker
"Scientists know their stuff but are rarely good storytellers, whereas good storytellers rarely possess the necessary sweeping command of a scientific discipline. Zirker is that rare animal who can both communicate the most demanding technical detail and make it accessible."— New Scientist-- Chris Almond
In Killer Fat, Natalie Boero examines how and why obesity emerged as a major public health concern and national obsession in recent years. Using primary sources and in-depth interviews, Boero enters the world of bariatric surgeries, Weight Watchers, and Overeaters Anonymous to show how common expectations of what bodies are supposed to look like help to determine what sorts of interventions and policies are considered urgent in containing this new kind of disease.
Boero argues that obesity, like the traditional epidemics of biological contagion and mass death, now incites panic, a doomsday scenario that must be confronted in a struggle for social stability. The “war” on obesity, she concludes, is a form of social control. Killer Fat ultimately offers an alternate framing of the nation’s obesity problem based on the insights of the “Health at Every Size” movement.
The next few years will see a major revolution in the technology used to deliver television services as the world moves from analog to digital television. Presently, all existing textbooks dealing with analog television standards (NTSC and PAL) are becoming obsolete as the prevalence of digital technology continues to become more widespread. Now, Digital Television: Technology and Standards fills the need for a single, authoritative textbook that covers all aspects of digital television technology.
Divided into three main sections, Digital Television explores:
Video: MPEG-2, which is at the heart of all digital video broadcasting services
Audio: MPEG-2 Advanced Audio Coding and Dolby AC-3, which will be used internationally in digital video broadcasting systems
Systems: MPEG, modulation transmission, forward error correction, datacasting, conditional access, and digital storage media command and control
Complete with tables, illustrations, and figures, this valuable textbook includes problems and laboratories at the end of each chapter and also offers a number of exercises that allow students to implement the various techniques discussed using MATLAB. The authors' coverage of implementation and theory makes this a practical reference for professionals, as well as an indispensable textbook for advanced undergraduates and graduate-level students in electrical engineering and computer science programs.
When a deadly diphtheria epidemic swept through Nome, Alaska, in 1925, the local doctor knew that without a fresh batch of antitoxin, his patients would die. The lifesaving serum was a thousand miles away, the port was icebound, and planes couldn't fly in blizzard conditions—only the dogs could make it. The heroic dash of dog teams across the Alaskan wilderness to Nome inspired the annual Iditarod Trail Sled Dog Race and immortalized Balto, the lead dog of the last team whose bronze statue still stands in New York City's Central Park. This is the greatest dog story, never fully told until now.
This book is designed to provide contemporary readers with an understanding of the emerging high-speed signal integrity issues that are creating roadblocks in digital design. Written by the foremost experts on the subject, it leverages concepts and techniques from non-related fields such as applied physics and microwave engineering and applies them to high-speed digital design—creating the optimal combination between theory and practical applications.
Following an introduction to the importance of signal integrity, chapter coverage includes:Electromagnetic fundamentals for signal integrity Transmission line fundamentals Crosstalk Non-ideal conductor models, including surface roughness and frequency-dependent inductance Frequency-dependent properties of dielectrics Differential signaling Mathematical requirements of physical channels S-parameters for digital engineers Non-ideal return paths and via resonance I/O circuits and models Equalization Modeling and budgeting of timing jitter and noise System analysis using response surface modeling
Each chapter includes many figures and numerous examples to help readers relate the concepts to everyday design and concludes with problems for readers to test their understanding of the material. Advanced Signal Integrity for High-Speed Digital Designs is suitable as a textbook for graduate-level courses on signal integrity, for programs taught in industry for professional engineers, and as a reference for the high-speed digital designer.
In this simple, descriptive treatment of Tesla's work:
- We start with the analysis of Tesla's experiment in his US patent 787412, providing explanations for his lower bounds, requirements, and superluminal speeds. Modes of operation of Tesla transformer are analyzed, and the true nature of the so-called Tesla-wave explained, considering what renders it to be the most significant technological discovery to date.
- We recognize that the very discovery of radio is a witness to the physical existence of invisible, exclusively 3-dimensional worlds, and spherical potential waves in a fully three-dimensional imaginary space are a fundamental phenomenon and physical reality.
- We progress to discuss implications and applications, and claim that properly constructed radio waves do not travel through our visible domain, allowing for efficient wireless energy transfer irrespective of distance.
- Finally, concentrated in one of the last of the 12 chapters, we present a concise mathematical treatment based on Maxwell's equations in characterizing the Tesla effect.
Redefining the thinking outside-the-box and challenging the state of the art in modern physics, I submit this innovation to your careful scrutiny. This descriptive work is accessible to any reader, including physics and mathematics scholars skilled in the art. The combined experience in the above treatment yields a novel, simple, yet comprehensive view of the spatial construction of the universe, above and beyond the everyday three-dimensional reality experienced by physical senses.
No sensationalist descriptions involving time travel, weapons of global destruction, Soviet military research, mind alteration, age reversal, UFOs, aliens, and a myriad of other manufactured and unrelated topics, are contained in this text. No strings, tensors, elementary particles, or any of the traditional special relativity effects are associated with Tesla waves, and are not mentioned in this text. The most significant problem in theoretical interpretation of Tesla's ideas to date - was the avoidance of the most obvious solution.
Read this flagship book, and discover that the universe is so small that we are all intimately connected through a countably infinite set of pathways of ever decreasing length, and that it is yet so large, that it escapes our senses.
Universe is a lattice of countably infinitely many, mutually embedded, distinct, experientially equivalent, fully-fledged three-dimensional worlds, with all corresponding lengths ratio of Pi/2. Illustrated in C^3 , universe is simply a sphere of radius zero.
Key Features:Acts as a timely introduction for researchers, graduate students and engineers who want to design and deploy subband adaptive filters in their research and applications. Bridges the gaps between two distinct domains: adaptive filter theory and multirate signal processing. Uses a practical approach through MATLAB®-based source programs on the accompanying CD. Includes more than 100 M-files, allowing readers to modify the code for different algorithms and applications and to gain more insight into the theory and concepts of subband adaptive filters.
Subband Adaptive Filtering is aimed primarily at practicing engineers, as well as senior undergraduate and graduate students. It will also be of interest to researchers, technical managers, and computer scientists.
Key features include:
* Numerous problems at the end of each chapter to aid development and understanding
* Examples and case studies provided throughout the book in a wide range of applications bring the text to life and place the theory into context
* A set of 60+ MATLAB software m-files allowing the reader to quickly design and apply any of the nonlinear signal processing algorithms described in the book to an application of interest is available on the accompanying FTP site.
Here, you can enjoy Dr. Emoto's captivating water-crystal photographs and text in this unique collection. The possible benefits you may experience include decreased joint and back pain; improved function of the nervous, circulatory, lymphatic, and immune systems; and the release of negative emotions such as anxiety, self-pity, and depression. The combination of images and words in Water Crystal Healing concentrates consciousness as never before, providing a unique experience for healing.
Organized into 13 chapters, this edition starts with an overview of the basic principles of electromagnetism. This text then presents a detailed discussion of Laplace's equation and a treatment of multiple effects, since such material is of considerable significance in the development of radiation theory. Other chapters consider the electromagnetic field equations, which are developed in the time-dependent form. This book discusses as well the subjects of wave propagation in space as well as in material media. The final chapter presents an introduction to relativistic electrodynamics.
This book is a valuable resource for physicists, engineers, and readers who are interested in the applications of electrodynamics in modern physics.
From Russia to Bengal to Palm Beach, Randall Packard’s far-ranging narrative traces the natural and social forces that help malaria spread and make it deadly. He finds that war, land development, crumbling health systems, and globalization—coupled with climate change and changes in the distribution and flow of water—create conditions in which malaria's carrier mosquitoes thrive. The combination of these forces, Packard contends, makes the tropical regions today a perfect home for the disease.
Authoritative, fascinating, and eye-opening, this short history of malaria concludes with policy recommendations for improving control strategies and saving lives.
This second edition contains an additional chapter on earth station design and gives extensive focus to space based weapon systems, satellite interference and future trends in satellite technology. Extra information has also been provided on all of the first edition’s topics to enhance the existing coverage.Fully updated new edition with latest technological developments Covers the full range of important applications such remote sensing, weather forecasting, navigational, scientific and military applications Amply illustrated with figures and photographs, this book also contains problems with solutions, which is of benefit students at undergraduate and graduate levels An indispensible book for professionals and students in the field of satellite technology Companion website provides a complete and updated compendium on satellites and satellite launch vehicles
The plague first sailed into San Francisco on the steamer Australia, on the day after New Year’s in 1900. Though the ship passed inspection, some of her stowaways—infected rats—escaped detection and made their way into the city’s sewer system. Two months later, the first human case of bubonic plague surfaced in Chinatown.
Initially in charge of the government’s response was Quarantine Officer Dr. Joseph Kinyoun. An intellectually astute but autocratic scientist, Kinyoun lacked the diplomatic skill to manage the public health crisis successfully. He correctly diagnosed the plague, but because of his quarantine efforts, he was branded an alarmist and a racist, and was forced from his post. When a second epidemic erupted five years later, the more self-possessed and charming Dr. Rupert Blue was placed in command. He won the trust of San Franciscans by shifting the government’s attack on the plague from the cool remove of the laboratory onto the streets, among the people it affected. Blue preached sanitation to contain the disease, but it was only when he focused his attack on the newly discovered source of the plague, infected rats and their fleas, that he finally eradicated it—truly one of the great, if little known, triumphs in American public health history.
With stunning narrative immediacy fortified by rich research, Marilyn Chase transports us to the city during the late Victorian age—a roiling melting pot of races and cultures that, nearly destroyed by an earthquake, was reborn, thanks in no small part to Rupert Blue and his motley band of pied pipers.
From the Hardcover edition.
Relive the heartwarming true story of the discovery of insulin as it's never been told before. Written with authentic detail and suspense, and featuring walk-ons by William Howard Taft, Woodrow Wilson, and Eli Lilly himself, among many others.
Award-winning medical historian Victoria A. Harden approaches the AIDS virus from philosophical and intellectual perspectives in the history of medical science, discussing the process of scientific discovery, scientific evidence, and how laboratories found the cause of AIDS and developed therapeutic interventions. Similarly, her book places AIDS as the first infectious disease to be recognized simultaneously worldwide as a single phenomenon.
After years of believing that vaccines and antibiotics would keep deadly epidemics away, researchers, doctors, patients, and the public were forced to abandon the arrogant assumption that they had conquered infectious diseases. By presenting an accessible discussion of the history of HIV/AIDS and analyzing how aspects of society advanced or hindered the response to the disease, AIDS at 30 illustrates for both medical professionals and general readers how medicine identifies and evaluates new infectious diseases quickly and what political and cultural factors limit the medical community’s response.
Dr Michael Ainslie is eminently qualified to write this unique book. He has worked on sonar performance modeling problems since 1983. He has written many peer reviewed research articles and conference papers related to sonar performance modeling, making contributions in the fields of sound propagation and detection theory.
When Freud and Halsted began their experiments with cocaine in the 1880s, neither they, nor their colleagues, had any idea of the drug's potential to dominate and endanger their lives. An Anatomy of Addiction tells the tragic and heroic story of each man, accidentally struck down in his prime by an insidious malady: tragic because of the time, relationships, and health cocaine forced each to squander; heroic in the intense battle each man waged to overcome his affliction. Markel writes of the physical and emotional damage caused by the then-heralded wonder drug, and how each man ultimately changed the world in spite of it—or because of it. One became the father of psychoanalysis; the other, of modern surgery. Here is the full story, long overlooked, told in its rich historical context.
"The definitive social history of the medical profession in America....A monumental achievement."—H. Jack Geiger, M.D., New York Times Book Review
Eric Schmidt is one of Silicon Valley’s great leaders, having taken Google from a small startup to one of the world’s most influential companies. Jared Cohen is the director of Google Ideas and a former adviser to secretaries of state Condoleezza Rice and Hillary Clinton. With their combined knowledge and experiences, the authors are uniquely positioned to take on some of the toughest questions about our future: Who will be more powerful in the future, the citizen or the state? Will technology make terrorism easier or harder to carry out? What is the relationship between privacy and security, and how much will we have to give up to be part of the new digital age?
In this groundbreaking book, Schmidt and Cohen combine observation and insight to outline the promise and peril awaiting us in the coming decades. At once pragmatic and inspirational, this is a forward-thinking account of where our world is headed and what this means for people, states and businesses.
With the confidence and clarity of visionaries, Schmidt and Cohen illustrate just how much we have to look forward to—and beware of—as the greatest information and technology revolution in human history continues to evolve. On individual, community and state levels, across every geographical and socioeconomic spectrum, they reveal the dramatic developments—good and bad—that will transform both our everyday lives and our understanding of self and society, as technology advances and our virtual identities become more and more fundamentally real.
As Schmidt and Cohen’s nuanced vision of the near future unfolds, an urban professional takes his driverless car to work, attends meetings via hologram and dispenses housekeeping robots by voice; a Congolese fisherwoman uses her smart phone to monitor market demand and coordinate sales (saving on costly refrigeration and preventing overfishing); the potential arises for “virtual statehood” and “Internet asylum” to liberate political dissidents and oppressed minorities, but also for tech-savvy autocracies (and perhaps democracies) to exploit their citizens’ mobile devices for ever more ubiquitous surveillance. Along the way, we meet a cadre of international figures—including Julian Assange—who explain their own visions of our technology-saturated future.
Inspiring, provocative and absorbing, The New Digital Age is a brilliant analysis of how our hyper-connected world will soon look, from two of our most prescient and informed public thinkers.
PKU (phenylketonuria) is a genetic disorder that causes severe cognitive impairment if it is not detected and treated with a strict and difficult diet. Programs to detect PKU and start treatment early are deservedly considered a public health success story. Some have traded on this success to urge expanded newborn screening, defend basic research in genetics, and confront proponents of genetic determinism. In this context, treatment for PKU is typically represented as a simple matter of adhering to a low-phenylalanine diet. In reality, the challenges of living with PKU are daunting.
In this first general history of PKU, a historian and a pediatrician explore how a rare genetic disease became the object of an unprecedented system for routine testing. The PKU Paradox is informed by interviews with scientists, clinicians, policymakers, and individuals who live with the disease. The questions it raises touch on ongoing controversies about newborn screening and what happens to blood samples collected at birth. -- M. Susan Lindee, University of Pennsylvania
Several themes explored in the book illustrate ways in which non-medical factors influence our views of a disease and our reaction to it. One of these themes is the tendency to focus blame for the spread of a disease on a particular group (e.g., women, blacks, sinners). The balance between protecting the rights of individuals and protecting the public health, in issues such as whether to quarantine the infected and whether to require mandatory testing for the disease, is another theme. A third theme is the persistent reluctance of many Americans to discuss venereal disease openly because it involves sex, a subject that we are often not comfortable talking about.
In this highly original account, Stepan sheds new light on the role of science in reformulating issues of race, gender, reproduction, and public health in an era when the focus on national identity was particularly intense. Drawing upon a rich body of evidence concerning the technical publications and professional meetings of Latin American eugenicists, she examines how they adapted eugenic principles to local contexts between the world wars. Stepan shows that Latin American eugenicists diverged considerably from their counterparts in Europe and the United States in their ideological approach and their interpretations of key texts concerning heredity.
Rosen, writing in the 1950s, may have had good reason to believe that infectious diseases would soon be conquered. But as Dr. Pascal James Imperato writes in the new foreword to this edition, infectious disease remains a grave threat. Globalization, antibiotic resistance, and the emergence of new pathogens and the reemergence of old ones, have returned public health efforts to the basics: preventing and controlling chronic and communicable diseases and shoring up public health infrastructures that provide potable water, sewage disposal, sanitary environments, and safe food and drug supplies to populations around the globe.
A revised introduction by Elizabeth Fee frames the book within the context of the historiography of public health past, present, and future, and an updated bibliography by Edward T. Morman includes significant books on public health history published between 1958 and 2014. For seasoned professionals as well as students, A History of Public Health is visionary and essential reading.
Little more than one hundred years ago, maps of the world still boasted white space: places where no human had ever trod. Within a few short decades the most hostile of the world’s environments had all been conquered. Likewise, in the twentieth century, medicine transformed human life. Doctors took what was routinely fatal and made it survivable. As modernity brought us ever more into different kinds of extremis, doctors pushed the bounds of medical advances and human endurance. Extreme exploration challenged the body in ways that only the vanguard of science could answer. Doctors, scientists, and explorers all share a defining trait: they push on in the face of grim odds. Because of their extreme exploration we not only understand our physiology better; we have also made enormous strides in the science of healing.
Drawing on his own experience as an anesthesiologist, intensive care expert, and NASA adviser, Dr. Kevin Fong examines how cuttingedge medicine pushes the envelope of human survival by studying the human body’s response when tested by physical extremes. Extreme Medicine explores different limits of endurance and the lens each offers on one of the systems of the body. The challenges of Arctic exploration created opportunities for breakthroughs in open heart surgery; battlefield doctors pioneered techniques for skin grafts, heart surgery, and trauma care; underwater and outer space exploration have revolutionized our understanding of breathing, gravity, and much more. Avant-garde medicine is fundamentally changing our ideas about the nature of life and death.
Through astonishing accounts of extraordinary events and pioneering medicine, Fong illustrates the sheer audacity of medical practice at extreme limits, where human life is balanced on a knife’s edge. Extreme Medicine is a gripping debut about the science of healing, but also about exploration in its broadest sense—and about how, by probing the very limits of our biology, we may ultimately return with a better appreciation of how our bodies work, of what life is, and what it means to be human.