A masterful synchronization of history and cutting-edge science shines new light on humanity's darkest diagnosis.
In the wake of the Cancer Genome Atlas project's failure to provide a legible roadmap to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease. Tripping over the Truth follows the story of cancer’s proposed metabolic origin from the vaunted halls of the German scientific golden age to modern laboratories around the world. The reader is taken on a journey through time and science that results in an unlikely connecting of the dots with profound therapeutic implications.
Transporting us on a rich narrative of humanity’s struggle to understand the cellular events that conspire to form malignancy, Tripping over the Truth reads like a detective novel, full of twists and cover-ups, blind-alleys and striking moments of discovery by men and women with uncommon vision, grit, and fortitude. Ultimately, Christofferson arrives at a conclusion that challenges everything we thought we knew about the disease, suggesting the reason for the failed war against cancer stems from a flawed paradigm that categorizes cancer as an exclusively genetic disease.
For anyone affected by this terrifying disease and the physicians who struggle to treat it, this book provides a fresh and hopeful perspective. It explores the new and exciting non-toxic therapies born from the emerging metabolic theory of cancer. These therapies may one day prove to be a turning point in the struggle against our ancient enemy. We are shown how the metabolic theory redraws the battle map, directing researchers to approach cancer treatment from a different angle, framing it more like a gentle rehabilitation rather than all-out combat. In a sharp departure from the current “targeted” revolution occurring in cancer pharmaceuticals, the metabolic therapies highlighted have one striking feature that sets them apart—the potential to treat all types of cancer because they exploit the one weakness that is common to every cancer cell: dysfunctional metabolism.
With contributions from Thomas Seyfried, PhD, author of Cancer as a Metabolic Disease; Miriam Kalamian, EdM, MS, CNS, author of Keto for Cancer; and Beth Zupec Kania, consultant nutritionist of The Charlie Foundation.
In this groundbreaking book, Gary Null debunks the commonly accepted belief that drugs and chemotherapy are the only cures for cancer and explores the alternative treatments that most mainstream doctors will never discuss with their patients. Dr. Null asserts that there are foods and supplements that boost the body’s immune system and can actually prevent and reverse cancer. Did you know that eating lemons and melons can help balance your body’s pH, which will help prevent and treat cancer? You knew that fiber is important for a healthy diet, but did you know that it lowers the risk of breast, colorectal, uterine, and prostate cancers? Have you heard of maitake mushrooms, which kill cancer cells by enhancing the activity of T-helper cells? In addition to diet, Dr. Null discusses important supplements and herbs and cutting-edge therapies you may never have heard of. With twenty-five cancer-fighting recipes and testimonials from individuals who have found health through Dr. Null’s methods, this book could save your life.
Cancer is not randomly distributed in the United States. Its incidence varies by race, ethnicity, socioeconomic status, and other geographic and demographic factors. This volume, co-published with the American Cancer Society, is the first to examine the biological, racial, and socioeconomic factors that influence cancer incidence and survival. In addition, it presents 15 previously unpublished, evidence-based interventions to reduce and eliminate cancer disparities.
The book explains the nature, scope, and causes of cancer disparities across different populations and then presents unique programs proven to reduce such inequalities in the areas of cancer prevention, screening and early detection, treatment, and survivorship. They represent a variety of cancers, populations, and communities across the U.S. Descriptions of each intervention include tests of effectiveness and are written in sufficient detail for readers to replicate them within their own communities.Key Features:
Offers an in-depth look at the latest research behind cancer disparitiesWritten by highly respected and published cancer researchersIncludes 15 never-before published, evidence-based interventions that readers can replicateDiscusses breast, colorectal, cervical, and other pernicious cancersIncludes interventions for African-American, Hispanic, Native American, and other populations
Rancour has an honest, humane, funny, and poetic style. She sweeps you along with her compassion, her wit, and her unerring ability to see into the truth of the matter. This book is for anyone who has an interest in what goes on in the patient rooms, hallways, stairwells, and elevators of a cancer hospital. You wont be able to put it down.
In telling these stories, Lippe and Le alternate chapters. Lippe writes about the early signs that something was wrong; Le continues with a description of pancreatic cancer, its symptoms, and its treatments. Lippe talks about his prognosis, contemplates the prospect of death, and describes how he began to cope; Le explains the importance, for both doctor and patient, of balancing hope and truth. Lippe speaks frankly about the toll the disease takes on his marriage and family; Le offers a general picture of what most patients can expect with their illness. The book concludes with Lippe and Le’s reflections on their partnership in treating cancer, lessons they have learned, and their thoughts about the positive things that sometimes emerge from illness.
Pancreatic Cancer offers clear explanations of what the disease is, describes what people with the disease will feel physically and mentally, and discusses current treatments and future directions of research. The authors hope that their honest yet hopeful perspective will help all people with cancer and those who care about them.
Oncology Board Review: Blueprint Study Guide and Q&A is a concise, outline-based study guide covering the topics that appear on the Medical Oncology Certification Exam. This second edition has been thoroughly revised to include new treatment regimens, clinical guidelines, and other updates impacting the field and reflected on the test.
The book includes all topics listed in the American Board of Internal Medicine (ABIM) blueprint as essential material for the Medical Oncology Certification Exam. The coverage spans all hematologic malignancies and solid tumors, beginning with the epidemiology, and followed by the etiology and risk factors of the disease, staging, signs and symptoms, diagnostic criteria, indications for treatment, prognostic factors, treatment recommendations, and special considerations. Later chapters review other major subspecialty areas found on the exam including cancer genetics and tumor biology, supportive and palliative care, bone marrow transplantation, and biostatistics. Each chapter includes key points summarized in digestible bullets for easy recall and self-assessment. And, now containing over 230 board style questions with answers and detailed rationales, Oncology Board Review, Second Edition is the go-to, quick review for any trainee preparing for initial certification and for oncologists preparing for recertification.New to this Edition:Includes over 230 board style questions and answers with rationalesNew chapter on Bone Marrow TransplantationThoroughly updated and revised chapters with all new treatment recommendations and FDA approvals for solid tumors and hematologic malignancies included.
Since the third edition (2003), there have been significant changes in treatment and resources. Working with Dr. Judd Moul, the Chairman of Urology at Duke and one of the world's top experts on prostate cancer, Marks provides the most up-to- date information on diagnosis, treatment, and common questions.
The AJCC Cancer Staging Atlas, 2nd Edition, is an official publication of the American Joint Committee on Cancer, the recognized international leader in state-of-the-art information on cancer staging. This Atlas has been created as a companion to the updated 7th Edition of the AJCC Cancer Staging Manual, which continues to disseminate the importance of anatomical and pathological staging in the management of cancer. This state-of-the-art, invaluable 2nd Edition includes a CD containing PowerPoint slides of all illustrations, additional color, and a user-friendly, easy-to-read layout. The AJCC Cancer Staging Atlas, 2nd Edition will serve as an indispensable reference for clinicians, registrars, students, trainees, and patients.
Over the past half century, deaths from heart disease, stroke, and so many other killers have fallen dramatically. But cancer continues to kill with abandon. In 2013, despite a four-decade “war” against the disease that has cost hundreds of billions of dollars, more than 1.6 million Americans will be diagnosed with cancer and nearly six hundred thousand will die from it.
A decade ago, Clifton Leaf, a celebrated journalist and a cancer survivor himself, began to investigate why we had made such limited progress fighting this terrifying disease. The result is a gripping narrative that reveals why the public’s immense investment in research has been badly misspent, why scientists seldom collaborate and share their data, why new drugs are so expensive yet routinely fail, and why our best hope for progress—brilliant young scientists—are now abandoning the search for a cure. “Through flowing prose Leaf delivers, alongside facts and data, stories on personalities involved in research, the fascinating process of solving an unusual and highly deadly cancer in Africa, and the heartbreaking realities of cancer treatment in children today. Leaf’s extensively investigated treatise will resonate with researchers and patients frustrated by the bureaucratic woes he delineates. Public policy makers, grant reviewers, and pharmaceutical researchers alike must consider Leaf’s indictment and proposed solutions” (Publishers Weekly). The Truth in Small Doses is that rare tale that will both outrage readers and inspire conversation and change.
Chapters are organized by site-specific disease. Each chapter presents the must-know key points, including treatment options by stage, relevant technical considerations, and important items for follow-ups. This crucial material makes the book an ideal companion for the practicing physician during rounds and other clinical settings. The book's organized format also lends itself to quick review for the board or MOC exams, and it can serve as a handy reference during a case review at a tumor board.
Key Features:The outline format and wealth of succinct tables make this a great quick reference Each chapter concludes with a list of selected, summarized studies relevant to the disease 51 disease-based chapters make it easy to find particular sites without having to sift through dense, broad text Supplemental sections at the end of the book provide quick access to normal tissue tolerance constraints as well as recommendations for managing symptoms after radiation therapy
Featuring five sections and over 50 chapters covering the Basic Principles of Tumor Immunology, Cancer Immunotherapy Targets and Classes, Immune Function in Cancer Patients, Disease Specific Treatments and Outcomes, and Regulatory Aspects of Cancer Immunotherapy, this book covers all major topics that have shaped the development of immunotherapy and propelled it to its current place at the forefront of cancer treatment innovation.
This volume is a comprehensive resource for oncologists and fellows, immunologists, cancer researchers, and related practitioners seeking understanding of the basic science and clinical applications of cancer immunotherapy. As well as presenting the evidence for immune-based cancer treatment, it positions immunotherapy in the context of other available cancer treatments and provides data on response rates, risks, and toxicities across a variety of diseases. Filled with detailed tables, and instructive illustrations, as well as key points for quick reference, Cancer Immunotherapy Principles and Practice simplifies a challenging and dynamic subject.
Key Features:Clearly summarizes the basic principles and research supporting cancer immunotherapy clinical translationContains expert guidance and treatment strategies for all immunotherapy classes and agents, including cell-based therapies, monoclonal antibodies, cytokine therapies, checkpoint inhibitors, oncolytic viruses, adjuvant approaches, and treatment combinationsIncludes expert perspectives from leading authorities in the fieldProvides information on all FDA-approved immunotherapies, including clinical management and outcome dataDiscusses clinical aspects of immunotherapy for individual cancer types, including melanoma and other skin cancers, lung cancers, gynecologic cancers, gastrointestinal cancers, hematologic cancers, genitourinary cancers, head and neck cancers, sarcomas, brain and other CNS cancers, breast cancer, and pediatric malignancies.Explains regulatory aspects behind the development and approval of immunotherapy drugs Includes Online Access to the Digital Book
An empathetic resource full of relatable patient stories, this book teaches patients and caregivers how to ask the right questions to get the best possible care--beginning at the moment of diagnosis. Drs. Jackson and Ryan explain how to work with a team of doctors and nurse practitioners to minimize symptoms and side effects while living as fully as possible in the face of cancer. They relay important information about understanding prognosis, and they translate what doctors mean when they describe tests, treatments, and medical procedures. Finally, they discuss hospice care and answer questions about continuing treatment and managing the final phase of life.
Based on new research and a groundbreaking program in which patients are treated with palliative care--along with the best cancer care--during the course of their illness, this honest and caring book provides the right advice to use at the right time throughout a journey with cancer. It allows a person with cancer to concentrate on living the best life possible, despite an uncertain future. Patients at every stage will find Living with Cancer a comprehensive, thoughtful, and accessible guide for navigating the illness and its treatment.
New information on developments in the molecular pathogenesis of this disease impacts how physicians approach and treat patients with CLL. The various predisposing factors for the disease are addressed along with current and future treatment modalities and recommended standards of care.
Key features include:introduction by Kanti Rai, MD who developed the Rai Classification and Staging system used in CLL diagnosis CLL in relationship to gene expression profiling and molecular abnormalities familial clustering and gene predisposition targeted therapy trials clinical patient management based upon stage and progression of disease
The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.
Since the first edition was published in 2006, Phillip M. Devlinís Brachytherapy has been acknowledged as the essential book on the practice. Inthis updated new edition, all chapters covering cancer sites have been significantly revised. Organized for specialists in several fields, Brachytherapy contains site-specific chapters that discuss how the evolving role of advanced image guidance has demonstrated greater efficacy and less toxicity. Clinical vignettes with images now accompany all site-specific chapters. The chapter on prostate brachytherapy has been expanded to include other indications in the genitourinary system, and there are two entirely new chaptersóone chronicling the history of brachytherapy and the other detailing the emergence of skin brachytherapy.
Dr. Devlin, a leading world authority on brachytherapy, has assembled other leaders in the field from world-renowned radiation oncology programs to enrichthis comprehensive text. From new data on medical outcomes to the costs and benefits of running a brachytherapy practice, Brachytherapy, Second Edition is the first and last word on what still is considered the most conformal radiotherapy technique in the field.
In the new edition:
Over 300 images accompany the chapter text and clinical vignettes
Essential tables and spreadsheets enhance the chapter on running a brachytherapy practice
Ten years of technological advancements are assimilated and reviewed in each site-specific chapter
Includes access to the fully-searchable downloadable ebook
From the Foreword:
ìAs education is essential to advance awareness of and proficiency in the full spectrum of brachytherapy applications, the appearance of the second edition of this highly regarded text is both a timely and most welcome event. The distinguished list of contributors to this work reads like a veritable ìWhoís Whoî of international brachytherapy expertise making this an indispensable resource for students and practitioners of this complex and challenging modality[Ö]A particularly welcome feature is the clinical vignettes at the close of every chapter that bring seemingly remote concepts to life in real world practical applications[Ö]With the second edition of Brachytherapy: Applications and Techniques, Dr. Devlin and colleagues give us a text that instills a profound appreciation for the critical value of this essential modality. This book makes it clear that brachytherapy not only works, it is an irreplaceable component of contemporary cancer care.î
--David Wazer, MD, FACRO, FACR, FASTRO, Professor and Chairman, Departments of Radiation Oncology, Alpert Medical School of Brown University, Providence, RI
Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body.
Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.
Now she and her co-authors have brought together the answers to the questions that women face in chapters that cover everything from how to prepare for going to the hospital to when you come home Amy and her co-authors answer:
Why am I so tired all the time?
What about these drains?
Should I worry about Lymphedema?
Implants or flap procedure?
Although everyone's experience is slightly different depending upon one's individual choice: mastectomy alone or mastectomy with reconstruction; the majority of the information applies to all women who had a mastectomy.
Amy and her co-authors include chapters on key issues all women face including wound management, scar massage, dressing and bathing, emotional recovery, and more. And although mastectomy is frightening, the authors make clear that today's procedure is not what it used to be.
Now What'is the first resource to provide all the information that women need after mastectomy and breast reconstruction surgery so that they can focus on what matters most: healing and staying well.
Williams Manual of Hematology, Ninth Edition provides a quick-access summary of the epidemiology, etiology, pathogenesis, diagnostic criteria, differential diagnosis, and therapy of blood cell and coagulation protein disorders. The 93 chapters of the Manual are a distillation of the disease- and therapy-focused chapters from the Ninth Edition of Williams Hematology. The book has been carefully edited to deliver only the most clinical point-of-care facts, making differential diagnosis faster, easier, and more efficient.
Concise but comprehensive, this complete guide includes sections on:
• Initial Clinical Evaluation
• Disorders of Red Cells
• Disorders of Granulocytes
• Disorders of Monocytes and Macrophages
• Principles of Therapy for Neoplastic Hematological Disorders
• The Clonal Myeloid Disorders
• The Polyclonal Lymphoid Diseases
• The Clonal Lymphoid and Plasma Cell Diseases
• Disorders of Platelet and Hemostasis
• Disorders of Coagulation Proteins
• Thrombosis and Antithrombotic Therapy
• Transfusion and Hemapheresis
Adaptive Radiation Therapy describes technological and methodological advances in the field of ART, as well as initial clinical experiences using ART for selected anatomic sites. Divided into three sections (radiobiological basis, current technologies, and clinical applications), the book covers:
Morphological and biological biomarkers for patient-specific planning Design and optimization of treatment plans Delivery of IMRT and IGRT intervention methodologies of ART Management of intrafraction variations, particularly with respiratory motion Quality assurance needed to ensure the safe delivery of ART ART applications in several common cancer types / anatomic sites
The technology and methodology for ART have advanced significantly in the last few years and accumulated clinical data have demonstrated the need for ART in clinical settings, assisted by the wide application of intensity modulated radiation therapy (IMRT) and image-guided radiation therapy (IGRT). This book shows the real potential for supplying every patient with individualized radiation therapy that is maximally accurate and precise.
As the pharmacology section continues to represent a major portion of the medical oncology exam and a key component on oncology MOC exams, this portable study guide will help prepare anyone looking to fine-tune their knowledge on cancer drugs before the test. Not to mention, with recent advancements in the field of cancer treatment, it has become more cumbersome to recall and maintain essential knowledge of every cancer therapeutic—making this book not only an exam resource but also a handy quick reference for oncologists and pharmacists alike.
KEY FEATURESConveniently organized and arranged by drug class and subtypes for easier recall and classification Includes proper dosage adjustments to account for liver and kidney dysfunction Features tables throughout that provide quick reference regarding FDA-approved medications Simplified diagrams and illustrations facilitate the pharmacokinetic processes
A Doody's Core Title for 2017!
Featuring a superb compilation of chapters related to hematology and oncology derived from Harrison’s Principles of Internal Medicine, Nineteenth Edition (including content from the acclaimed Harrison’s DVD, now available here in print), this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s. You will find 57 chapters from more than 75 renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation.
• Each chapter contains relevant information on the genetics, cell biology, pathophysiology, and treatment of specific disease entities
• Chapters on hematopoiesis, cancer cell biology, and cancer prevention reflect the rapidly growing knowledge in these areas
• Integration of pathophysiology with clinical management
• High-yield board review questions make this text ideal for keeping current or preparing for the boards
• Valuable appendix of laboratory values of clinical importance
Provides authoritative guidance from the IASLC the only global organization dedicated to the study of lung cancer. Includes new content on molecular testing, immunotherapy, early detection, staging and the IASLC staging system, surgical resection for stage I and stage II lung cancer, and stem cells in lung cancer.
Features a new full-color design throughout, as well as updated diagnostic algorithms.
When you or a loved one is faced with a cancer diagnosis, the need for accurate and trusted medical information becomes urgent. Naturopathic physician Lise N. Alschuler and medical journalist Karolyn A. Gazella present an overview of what cancer is, its causes and preventative strategies, an in-depth approach to integrative treatment options, descriptions of key body functions, and discussions of more than twenty specific cancers. The Definitive Guide to Cancer, now in its third edition, encourages you to take an integrative approach that embraces both alternative and conventional therapies across the spectrum of cancer prevention, treatment, and healing.
From the Trade Paperback edition.
The first edition described the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions.
The second edition will include coverage of the many new discoveries that have been made in the last five years: hCG analogues may be the actual driving signal of all human cancers. The editor estimates that 40% of the out of date material will be excluded and replaced with 40% of the exciting new findings. The book will also have a much clearer pregnancy and cancer focus.It provides comprehensive information on hCG from basic science to clinical medicineThe second edition will include coverage of the many new discoveries that have been made in the last five yearsUpdated material with new findings in the field
Essentials of Clinical Radiation Oncology has been designed to replicate a "house manual" created and used by residents in training and is a "one-stop" resource for practicing radiation oncologists, related practitioners, and radiation oncology residents entering the field.
Key Features:Offers digestible information as a learning guide for general practice Examines essential clinical questions which are answered with evidence-based data from important clinical studies Places clinical trials and data into historical context and points out relevance in current practice Provides quick reference tables on treatment options and patient selection, workup, and prognostic factors by disease site