In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group.
Key features include:
• Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups.
• How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism.
• Numerous examples and expanded discussions for complex concepts.
• Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice.
• An overview of structure activity relationships (SARs) and concepts that govern drug design.
• Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix.
Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry.
About the Authors
Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy.
Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.
NEW TO THIS EDITION:Three new chapters including new information on men’s health, women’s health, and pharmacogenomics and laboratory tests.Mini-cases embedded in each chapter provide therapy-related examples and reinforce important points made in the text.Quickview Charts give an overview of important clinical information including reference ranges and critical values.Learning Points focus on a clinical application of a major concept present in the chapter.
Government Is Us 2.0 picks up where the previous edition left off. It addresses the bigger questions that are being asked and discussed about the relationships among and between citizens and their governments, how individuals and agencies govern, and the institutional elements that keep us from engendering long-term, socially just participatory change.
The central argument of Government Is Us 2.0 is that much can be done to bridge the gulf between citizens and their governments. The chapter authors offer practical suggestions on how public administrators can productively involve citizens in government work, with steps that will increase citizens' trust in government through opportunities for direct connection and collaboration.
TechPrep™ contains more than 1,000 review questions to help readers prepare for national technician certification exams. A robust Practice Session feature allows users to create custom quizzes by setting topic area, time, and number of questions. The Simulated Exam function lets readers practice their test skills by providing a 90 question, 120 minute test, with questions weighted to mimic national certification exams. Students using TechPrep™ receive instant, automated scoring, and can quickly identify areas they’ve mastered, or practice subjects where they need improvement. Alone or with the new edition of the Manual for Pharmacy Technicians, 4th Edition andall-new Workbook for the Manual for Pharmacy Technicians, the Pharmacy Technician Review Guide and Practice Exam offers the most comprehensive review to help you achieve certification!
A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging.
Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach.
In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.
Although rotations are crucial to the development of skills needed to practice pharmacy, there has been little available to guide students in the best way to prepare and make the most of these experiences—until now.
Maximize Your Rotations: ASHP’s Student Guide to IPPEs, APPEs, and Beyond breaks down everything you need to know into easy-to-navigate chapters. Inside you will find the skills required to excel while on IPPE or APPE rotations, along with competencies that may be unique to one type of rotation or another.
Each chapter is written by an experienced preceptor, lending a valuable perspective.
By using this text, you will gain an appreciation of the general expectations and typical activities of each rotation experience before you begin. Better preparation means better performance. Maximize Your Rotations will also be a resource throughout the experiential year, offering everything from reminders of clinical issues and statistical reviews to advice on interviewing, CV writing, professional organizations, and more.
Maximize Your Rotations means less time getting up to speed—and more time getting ahead in your career. Your rotation experience can be the launching pad for your career, and there’s no better guide than Maximize Your Rotations.
Each chapter contains learning objectives, case studies, bibliographies, and charts that summarize the causes of high and low test results.
New for this edition: Updated and expanded Quick View tables in each chapter now match those in the popular quick-reference, Interpreting Laboratory Data: A Point-of-Care Guide New glossary of acronyms is right up front for a streamlined reference Normal value ranges of all tests have been standardized by an expert pathologist New and updated cases in each chapter apply your Basic Skills in clinical situations Reorganized to highlight the application of concepts by body system, and in special populationsBasic Skills in Interpreting Laboratory Data offers features that will help pharmacy students not only understand and engage with the material but also will streamline the transition from classroom to practice setting. After studying with this trusted text, students and pharmacists will more effectively monitor patient therapy, evaluate test results, and improve outcomes through optimal and focused pharmacotherapy.
For more than two decades, readers faced with a diagnosis of breast cancer have relied on Dr. Susan Love's Breast Book to guide them through the frightening thicket of research and opinion to find the best options for their particular situations. This sixth edition explains advances in targeted treatments, hormonal therapies, safer chemotherapy, and immunologic approaches as well as new forms of surgery and radiation. There is extensive guidance for the many women now living for years with metastatic breast cancer. With Dr. Love's warm support, readers can sort the facts from the fads, ask the right questions, and recognize when a second opinion might be wise.
From Abilify to Zyrtec and nearly every drug in between, Mosby's Drug Reference for Health Professions, 3rd Edition is the must-have item for every aspiring health professional. In fact, it's the only drug book on the market written specifically for health professionals! Filled with vital details your students need to know about patient medications, this updated edition features concise, reliable information that is easy to navigate and simple to follow. Key details are presented in short monographs for 1,000 generic drugs (including 4,500 trade-name drugs) that are listed alphabetically. Precautions and considerations sections are tailored to circumstances your students will face on the job. Make certain they have the most relevant information on hand for their studies and for clinical practice with Mosby's Drug Reference for Health Professions, 3rd Edition!
Decision making based on personal experience alone, without knowledge from well-designed, controlled, randomized trials with adequate sample size, often overestimates the efficacy and underestimates the safety risks associated with drugs. This book provides a roadmap that is instructional and, most importantly, practical for the pharmacist so these new skills can be applied immediately in practice.
Based on a five-step process perfected over ten years at the University of Missouri, Kansas City, School of Pharmacy, this exciting new approach will:
· Reduce complexity
· Shorten time for decision making support
· Maintain rigor
· Categorize quality of the evidence in a simple, straightforward, and logical manner
· Provide a process designed specifically for pharmacists making drug therapy decisions
Use of examples, tables, diagrams, and key points highlighted throughout the book and summarized at the end of each chapter provide the pharmacist with skills they can implement the next day to begin applying EBM principles to their practice.
This edition includes greatly expanded focus on stem cells, including adult and embryonic stem cells and progenitor populations that may soon lead to new tissue engineering therapies for heart disease, diabetes, and a wide variety of other diseases that afflict humanity. This up-to-date coverage of stem cell biology and other emerging technologies is complemented by a series of new chapters on recent clinical experience in applying tissue engineering. The result is a comprehensive textbook that we believe will be useful to students and experts alike.
New to this edition:
*Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves
*Expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems
--Hans Camenzind, inventor of the 555 timer (the world's most successful integrated circuit), and author of Much Ado About Almost Nothing: Man's Encounter with the Electron (Booklocker.com)
"A fabulous book: well written, well paced, fun, and informative. I also love the sense of humor. It's very good at disarming the fear. And it's gorgeous. I'll be recommending this book highly."
--Tom Igoe, author of Physical Computing and Making Things Talk
Want to learn the fundamentals of electronics in a fun, hands-on way? With Make: Electronics, you'll start working on real projects as soon as you crack open the book. Explore all of the key components and essential principles through a series of fascinating experiments. You'll build the circuits first, then learn the theory behind them!
Build working devices, from simple to complex You'll start with the basics and then move on to more complicated projects. Go from switching circuits to integrated circuits, and from simple alarms to programmable microcontrollers. Step-by-step instructions and more than 500 full-color photographs and illustrations will help you use -- and understand -- electronics concepts and techniques.Discover by breaking things: experiment with components and learn from failure Set up a tricked-out project space: make a work area at home, equipped with the tools and parts you'll need Learn about key electronic components and their functions within a circuit Create an intrusion alarm, holiday lights, wearable electronic jewelry, audio processors, a reflex tester, and a combination lock Build an autonomous robot cart that can sense its environment and avoid obstacles Get clear, easy-to-understand explanations of what you're doing and why
Generic/trade names Route of administration Common dosage Side effects Auxiliary labelMedication Safety and Error Prevention chapter helps you confidently address growing concerns related to patient safety and prevent medication-related errors. Revised Math Calculations chapter incorporates helpful information to clarify complex pharmaceutical calculations. Updated content prepares you for the Pharmacy Technician Certification (PTC) exam and highlights current concerns you'll encounter in the workforce:
HIPAA regulationsThe Medicare Modernization Act Legal parameters for the sale of pseudoephedrine productsThe issuance of multiple Schedule II prescriptionsPending legislation requirements for Medicaid prescriptionsThe United States Pharmacopeia (USP) New full-color photographs familiarize you with current practice settings. Learning games and certification review quizzes on the companion Evolve website reinforce your understanding and challenge you to apply what you've learned.
Already, scientists have constructed prototypes for circuit boards built of millions of precisely arranged atoms. The advent of this kind of atomic precision promises to change the way we make things—cleanly, inexpensively, and on a global scale. It allows us to imagine a world where solar arrays cost no more than cardboard and aluminum foil, and laptops cost about the same.
A provocative tour of cutting edge science and its implications by the field's founder and master, Radical Abundance offers a mind-expanding vision of a world hurtling toward an unexpected future.
A masterful synchronization of history and cutting-edge science shines new light on humanity's darkest diagnosis.
In the wake of the Cancer Genome Atlas project's failure to provide a legible roadmap to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease. Tripping over the Truth follows the story of cancer’s proposed metabolic origin from the vaunted halls of the German scientific golden age to modern laboratories around the world. The reader is taken on a journey through time and science that results in an unlikely connecting of the dots with profound therapeutic implications.
Transporting us on a rich narrative of humanity’s struggle to understand the cellular events that conspire to form malignancy, Tripping over the Truth reads like a detective novel, full of twists and cover-ups, blind-alleys and striking moments of discovery by men and women with uncommon vision, grit, and fortitude. Ultimately, Christofferson arrives at a conclusion that challenges everything we thought we knew about the disease, suggesting the reason for the failed war against cancer stems from a flawed paradigm that categorizes cancer as an exclusively genetic disease.
For anyone affected by this terrifying disease and the physicians who struggle to treat it, this book provides a fresh and hopeful perspective. It explores the new and exciting non-toxic therapies born from the emerging metabolic theory of cancer. These therapies may one day prove to be a turning point in the struggle against our ancient enemy. We are shown how the metabolic theory redraws the battle map, directing researchers to approach cancer treatment from a different angle, framing it more like a gentle rehabilitation rather than all-out combat. In a sharp departure from the current “targeted” revolution occurring in cancer pharmaceuticals, the metabolic therapies highlighted have one striking feature that sets them apart—the potential to treat all types of cancer because they exploit the one weakness that is common to every cancer cell: dysfunctional metabolism.
With contributions from Thomas Seyfried, PhD, author of Cancer as a Metabolic Disease; Miriam Kalamian, EdM, MS, CNS, author of Keto for Cancer; and Beth Zupec Kania, consultant nutritionist of The Charlie Foundation.
The AJCC Cancer Staging Atlas, 2nd Edition, is an official publication of the American Joint Committee on Cancer, the recognized international leader in state-of-the-art information on cancer staging. This Atlas has been created as a companion to the updated 7th Edition of the AJCC Cancer Staging Manual, which continues to disseminate the importance of anatomical and pathological staging in the management of cancer. This state-of-the-art, invaluable 2nd Edition includes a CD containing PowerPoint slides of all illustrations, additional color, and a user-friendly, easy-to-read layout. The AJCC Cancer Staging Atlas, 2nd Edition will serve as an indispensable reference for clinicians, registrars, students, trainees, and patients.
First, there is a brief overview of the history and development of the spectroscope. This is followed by a short introduction to the theory of stellar spectra. The final parts of this section provide details of the necessary reference spectra required for instrument testing and spectral comparison. It concludes with a chapter covering the various types of spectroscopes available to the amateur.
Next, there is a series of "How to..." sections. These cover all aspects of setting up and using various types of commercially available and home-built spectroscopes. Transmission gratings are covered first, and then more complex models, all the way to the sophisticated Littrow design.
The final part of Astronomical Spectroscopy for Amateurs is about practical spectroscope design and construction. It contains a collection of detailed instructions covering the design and building of three different types of spectroscope, along with the necessary design theory (with minimal math). Developing an instrument in simple steps from the basic grating spectroscope, using standard "off the shelf" adaptors, the author describes how to build spectroscopes equal in performance to the better commercial units, constructed using basic hand tools for a fraction of the cost!
This is the only up-to-date practical spectroscopy book available to amateurs. For the first time, it also brings together an invaluable user knowledge base – a collection of observing, analyzing, and processing hints and tips that will allow the amateur to build up and develop important skills in preparing scientifically acceptable spectral data, which can make a valuable contribution to ProAm (professional/amateur) projects. It covers in detail all aspects of the design, construction techniques, testing, calibrating, and using a spectroscope – enough detail to enable the average amateur astronomer to successfully build and use his own spectroscope for a fraction of the current commercial cost.
This book is an ideal complement to Robinson’s Spectroscopy: the Key to the Stars (Springer 2007) and Martin’s Spectroscopic Atlas of Bright Stars (Springer, due 2009). Together, the three books form a complete package for all amateur astronomers who are interested in practical spectroscopy.
As Professor Chris Kitchin said, "If optical spectroscopy had not been invented then fully 75 percent of all astronomical knowledge would be unknown today, and yet the subject itself receives scant attention in astronomical texts." Olivier Thizy (of Shelyak Instruments, the builder of the LiHiResIII commercial spectroscope) writes on an Internet forum; "What is missing is tutorial books and "how to" books with amateur equipment? I believe spectroscopy is in general moving from builders to users (as CCD cameras did in the 1990's)... ...literature is following but slowly."
This is the practical spectroscopy book that amateur astronomers have been waiting for!
If you are a patient, gain a better understanding of how a pharmacy functions; if you are a health care provider, learn how to better communicate with retail pharmacists. A Prescription for Retail Pharmacy provides helpful advice for those already working behind the counter, as well. Explore what is expected of pharmacy technicians and new techniques for pharmacists to use in handling the typical problems they encounter.
Whether your problems are in front of the counter or behind it, A Prescription for Retail Pharmacy provides the cure!
Eve Herold's Beyond Human examines the medical technologies taking shape at the nexus of computing, microelectronics, engineering, nanotechnology, cellular and gene therapies, and robotics. These technologies will dramatically transform our lives and allow us to live for hundreds of years. Yet, with these blessings come complicated practical and ethical issues, some of which we can predict, but many we cannot.
Beyond Human taps the minds of doctors, scientists, and engineers engaged in developing a host of new technologies while telling the stories of some of the patients courageously testing the radical new treatments about to come into the market.
Beyond Human asks the difficult questions of the scientists and bioethicists who seek to ensure that as our bodies and brains become ever more artificial, we hold onto our humanity. In this new world, will everyone have access to technological miracles, or will we end up living in a world of radical disparities? How will society accommodate life spans that extend into hundreds of years? Will we and our descendants be able to bring about the dream of a future liberated by technology, or will we end up merely serving the machines and devices that keep us healthy, smart, young, and alive?
This book offers a complete review of the basic mathematics concepts and skills, which provide a foundation for more advanced understanding of pharmacy-related topics. The guide provides students with the pharmacy basics necessary for correctly interpreting prescriptions and drug orders, and for performing dosing calculations that technicians face every day.
The chapters are broken down into four units and are organized to complement most pharmacy technician training curricula and to support the ASHP model curriculum:
· Review of Mathematics
· Systems of Measurement
· Preparing for Problem Solving in Pharmacy
· Dosing Calculations and Other Pharmacy Problems
Key features throughout the book include:
· Chapter objectives
· Key terms and definitions
· Examples of problem scenarios or calculations questions and solutions
· “Tech Note!” —provides a highlight of key points within the chapters
· “Numbers at Work” —illustrates why key concepts are important to know and skills are critical to master
· Practice problems
· A test bank
· Appendices that include the parts of a prescription, a glossary of terms, conversions, and abbreviations tables.
For additional resources related to this book, visit www.ashp.org/techcalculations.
Filling the void, Biotechnology Operations: Principles and Practices reflects this integrative philosophy, serving as a practical guide for students, professionals, or anyone else with interests in the biotech industry. Although many books emphasize specific technical aspects of biotech, this is perhaps the first to integrate essential concepts of product development and scientific and management skills with the seven functional areas of biotechnology:
Biomanufacturing Clinical trials Nonclinical studies Project management Quality assurance Quality control Regulatory affairs
A practical roadmap to optimizing biotechnology operations, this reference illustrates how to use specific product planning, design, and project management processes to seamlessly merge plans and efforts in the key functional areas. Applying lessons learned throughout the nascent history of biotech, author Michael Roy highlights developmental principles that could bring future products to market more safely and efficiently. Drawing from his experiences working in industry and teaching a graduate course at the University of Wisconsin, this hotly anticipated book clarifies basic methodologies and practices to help reduce risks and resolve problems as future technological discoveries are developed into tangible products.
Integrated throughout the text are real-world applications that emphasize the relevance of thermodynamics principles to some of the most critical problems and issues of today, including a wealth of coverage of topics related to energy and the environment, biomedical/bioengineering, and emerging technologies.
In telling these stories, Lippe and Le alternate chapters. Lippe writes about the early signs that something was wrong; Le continues with a description of pancreatic cancer, its symptoms, and its treatments. Lippe talks about his prognosis, contemplates the prospect of death, and describes how he began to cope; Le explains the importance, for both doctor and patient, of balancing hope and truth. Lippe speaks frankly about the toll the disease takes on his marriage and family; Le offers a general picture of what most patients can expect with their illness. The book concludes with Lippe and Le’s reflections on their partnership in treating cancer, lessons they have learned, and their thoughts about the positive things that sometimes emerge from illness.
Pancreatic Cancer offers clear explanations of what the disease is, describes what people with the disease will feel physically and mentally, and discusses current treatments and future directions of research. The authors hope that their honest yet hopeful perspective will help all people with cancer and those who care about them.
50 Critical Cancer Answers provides the essential information a person needs to create a personal action plan to deal with cancer effectively. Each of the 50 short, easy-to-digest chapters includes a concise explanation of the most effective and sought after cancer treatment in the realms of traditional medicine, natural medicine, emotional support and spiritual care. A succinct commentary is provided to help the reader understand potential benefits, and if it is a realistic treatment option or not. Each chapter includes:
- An interview with an expert in the field of the chapter's topic
- A "smartphone scannable" QR code linking the reader to You Tube video containing author commentary on the relevant topic
- 5 tips from cancer survivors--all 50 cancer survivors have received treatment from the authors' Oasis of Hope cancer centers.
Don't let a cancer diagnosis define your circumstances. Instead, develop a plan to identify, attack, and beat cancer.
In addition to a history of the science behind the pursuit, directions are included for four easy-to-build projects, based around long-term NASA and Stanford Solar Center projects. The first three projects constitute self-contained units available as kits, so there is no need to hunt around for parts. The fourth – more advanced – project encourages readers to do their own research and track down items.
Getting Started in Radio Astronomy provides an overall introduction to listening in on the radio spectrum. With details of equipment that really works, a list of suppliers, lists of online help forums, and written by someone who has actually built and operated the tools described, this book contains everything the newcomer to radio astronomy needs to get going.