Biological drug products play a central role in combating human diseases; however, developing new successful biological drugs presents many challenges, including labor intensive production processes, tighter regulatory controls, and increased market competition. This book reviews the current state of the science, offering readers a single resource that sets forth the fundamentals as well as tested and proven development strategies for biological drugs. Moreover, the book prepares readers for the challenges that typically arise during drug development, offering straightforward solutions to improve their ability to pass through all the regulatory hurdles and deliver new drug products to the market.
Biological Drug Products begins with general considerations for the development of any biological drug product and then explores the strategies and challenges involved in the development of specific types of biologics. Divided into five parts, the book examines:Part 1: General Aspects Part 2: Proteins and Peptides Part 3: Vaccines Part 4: Novel Biologics Part 5: Product Administration/Delivery
Each chapter has been prepared by one or more leading experts in biological drug development. Contributions are based on a comprehensive review and analysis of the current literature as well as the authors' first-hand experience developing and testing new drugs. References at the end of each chapter serve as a gateway to original research papers and reviews in the field.
By incorporating lessons learned and future directions for research, Biological Drug Products enables pharmaceutical scientists and students to improve their success rate in developing new biologics to treat a broad range of human diseases.
Biomaterials: A Basic Introduction is a definitive resource for students entering biomedical or bioengineering disciplines. This text offers a detailed exploration of engineering and materials science, and examines the boundary and relationship between the two. Based on the author’s course lecture notes and many years of research, it presents students with the knowledge needed to select and design biomaterials used in medical devices. Placing special emphasis on metallic, ceramic, polymeric, and composite biomaterials, it explains the difference between materials science and materials engineering, introduces basic concepts and principles, and analyzes the critically important properties of biomaterials.
Explains Complex Theories Using Aspects of Daily Life
This text provides an appropriate balance between depth and broadness of coverage, and offers an understanding of the most important concepts and principles to students from a wide academic spectrum. It delivers the science of biomaterials in laymen terms, from a material standpoint, as well as a clinical applications point of view. It equips students majoring in materials science/engineering with knowledge on the fundamentals of how biomaterials behave at a biological level, and provides students majoring in medicine with information that is generally unavailable in traditional medical courses. The authors incorporate learning objectives at the beginning of each chapter, as well as chapter highlights, problems, and exercises at the end of each chapter. In addition, they present objectives, suggested activities, and reference material for further reading.Contains an overview of medical science vis-à-vis materials science, describes anatomy, histology, and cell biology Highlights health issues and diseases where biomaterials can easily find medical applications Presents knowledge of the relationship between the biomaterials and the living body Evaluates medical devices and looks into their respective regulations
Biomaterials: A Basic Introduction contains an overview of basic biomaterials and concepts, and is written for upper-division students in the US/Canada, and second-level students in universities worldwide.
Filling the void, Biotechnology Operations: Principles and Practices reflects this integrative philosophy, serving as a practical guide for students, professionals, or anyone else with interests in the biotech industry. Although many books emphasize specific technical aspects of biotech, this is perhaps the first to integrate essential concepts of product development and scientific and management skills with the seven functional areas of biotechnology:
Biomanufacturing Clinical trials Nonclinical studies Project management Quality assurance Quality control Regulatory affairs
A practical roadmap to optimizing biotechnology operations, this reference illustrates how to use specific product planning, design, and project management processes to seamlessly merge plans and efforts in the key functional areas. Applying lessons learned throughout the nascent history of biotech, author Michael Roy highlights developmental principles that could bring future products to market more safely and efficiently. Drawing from his experiences working in industry and teaching a graduate course at the University of Wisconsin, this hotly anticipated book clarifies basic methodologies and practices to help reduce risks and resolve problems as future technological discoveries are developed into tangible products.
The author’s continual participation in FDA QSR inspections and Notified Body ISO audits is reflected in updates to all chapters and appendices of the book, now bursting at the seams with:
New coverage of ISO 9001 and 13485 design control requirements More real-world examples from the medical device industry Additional detail for greater understanding and clarity Fresh templates for practical implementation Extensive references for further study
The book addresses design control elements such as design planning, input, output, review, verification, validation, change, transfer, and history, as well as risk management inclusive of human factors and usability, biocompatibility, the FDA Quality System Inspection Technique (QSIT) for design controls, and medical device regulations and classes in the US, Canada, and Europe.
Part I deals with the principles, mode of operation, and uses of various biomedical instruments and devices, including transducers, electrocardiograph, implantable electrical devices, biotelemetry, patient monitoring systems, hearing aids, and implantable insulin delivery systems. Parts II and III describe the basic principle of medical imaging devices and the application of computers in medicine, particularly in the fields of data management, critical care, clinical laboratory, radiology, artificial intelligence, and research. Part IV focuses on the application of biomaterials and biomechanics in orthopedic and accident investigation, while Part V considers the major functions of clinical engineering. Part VI provides the principles and application of mathematical models in physiological systems analysis.
This book is valuable as a general reference for courses in a biomedical engineering curriculum.
This book is particularly designed for scientists and engineers working in various industries, including food, consumer products, pharmaceuticals, medicine, agriculture, nutraceuticals, dietary supplements, cosmetics, flavors, and fragrances. It offers a broad perspective on a variety of applications and processes, providing research information, figures, tables, illustrations, and references.
The book also lays the groundwork for further advancements in encapsulation technology and controlled release applications. Catering to professionals, researchers, students, and general readers in academia, industry, and research institutions, the Handbook of Encapsulation and Controlled Release is a much-needed reference on the state of the field and an authoritative resource for continued research and development in encapsulation and controlled release technologies.
Never before have two revolutions with so much potential to save and prolong human life occurred simultaneously. The converging, synergistic power of the biochemical and digital revolutions now allows us to read every letter of life's code, create precisely targeted drugs to control it, and tailor their use to individual patients. Cancer, diabetes, Alzheimer's and countless other killers can be vanquished—if we make full use of the tools of modern drug design and allow doctors the use of modern data gathering and analytical tools when prescribing drugs to their patients.
But Washington stands in the way, clinging to outdated drug-approval protocols developed decades ago during medicine's long battle with the infectious epidemics of the past. Peter Huber, an expert in science, technology, and public policy, demonstrates why Washington's one-size-fits-all drug policies can't deal with diseases rooted in the complex molecular diversity of human bodies. Washington is ill-equipped to handle the torrents of data that now propel the advance of molecular medicine and is reluctant to embrace the statistical methods of the digital age that can. Obsolete economic policies, often rationalized as cost-saving measures, stifle innovation and suppress investment in the medicine that can provide the best cures at the lowest cost.
In the 1980s, an AIDS diagnosis was a death sentence, until the FDA loosened its throttling grip and began streamlining and accelerating approval of life-saving drugs. The Cure in the Code shows patients, doctors, investors, and policy makers what we must now do to capture the full life-saving and cost-saving potential of the revolution in molecular medicine. America has to choose. At stake for America is the power to lead the world in mastering the most free, fecund, competitive, dynamic, and intelligent natural resource on the planet—the molecular code that spawns human life and controls our health.
“essential reading for any physical scientist who is interested in performing biological research.” ―Contemporary Physics
"an ambitious text.... Each chapter contains protocols and the conceptual reasoning behind them, which is often useful to physicists performing biological experiments for the first time." –Physics Today
This fully updated and expanded text is the best starting point for any student or researcher in the physical sciences to gain firm grounding in the techniques employed in molecular biophysics and quantitative biology. It includes brand new chapters on gene expression techniques, advanced techniques in biological light microscopy (super-resolution, two-photon, and fluorescence lifetime imaging), holography, and gold nanoparticles used in medicine. The author shares invaluable practical tips and insider’s knowledge to simplify potentially confusing techniques. The reader is guided through easy-to-follow examples carried out from start to finish with practical tips and insider’s knowledge. The emphasis is on building comfort with getting hands "wet" with basic methods and finally understanding when and how to apply or adapt them to address different questions.
Jay L. Nadeauis a scientific researcher and head of the Biomedical Engineering in Advanced Applications of Quantum, Oscillatory, and Nanotechnological Systems (BEAAQONS) lab at Caltech and was previously associate professor of biomedical engineering and physics at McGill University.
Bringing together the leading pioneers in this field to write about their own work, Photoacoustic Imaging and Spectroscopy is the first to provide a full account of the latest research and developing applications in the area of biomedical photoacoustics.Photoacoustics can provide functional sensing of physiological parameters such as the oxygen saturation of hemoglobin. It can also provide high-contrast functional imaging of angiogenesis and hypermetabolism in tumors in vivo. Discussing these remarkable noninvasive applications and so much more, this reference is essential reading for all researchers in medical imaging and those clinicians working at the cutting-edge of modern biotechnology to develop diagnostic techniques that can save many lives and just as importantly do no harm.
The book provides instant answers about what to include in critical quality assurance and quality control SOPs and how to enhance productivity. The CD-ROM contains nineteen quality control and thirty-three quality assurance SOPs designed so that users can input them into their computers and use their Microsoft Word programs to edit and print these documents. The book ensures minimization of the number of documents, helping to reduce the nightmare-like aura that surrounds an FDA audit. The SOPs exclusively refer to the documents specially required for compliance; however, specific formats are not included to ensure that the electronic templates can be easily used by pharmaceutical, bulk pharmaceutical, medical device, and biotechnology industries.
The combination of text and CD-ROM presents a ready-to-use resource on the quality systems of aseptic pharmaceutical non-aseptic production and to provide general information and guidelines. They comprise a tool that can be used to develop a set of quality SOPs in order to support the road map established for the on-time successful start-up of the facility operation in compliance with the GMP requirements.
The stratum corneum is the interface between the sometimes harsh environment and the internal turmoil of the human body. Based on a large number of recent publications, this book explains the mechanisms involved in stratum corneum barrier function and hydration. It reflects 10 years of progress not only of the non-invasive biophysical assessment of skin physiology parameter, but also of the perfection of the available devices. It brings all research on epidermal water and transepidermal water loss in health and disease up-to-date with the revision of existing chapters as well as added chapters from new contributors on hydration and itching. This edition also includes new guidelines on the standardization of measurements.
Bioengineering of the Skin will enhance communication within the research community and will be useful for scientists in the skin bioengineering field by presenting methods that offer reliable and reproducible approaches for product testing in the pharmaceutical and cosmetic industries, as well as for basic research.
Nanobiomaterials in Dentistry: Applications of Nanobiomaterialsdiscusses synthesis methods and novel technologies involving nanostructured bio-active materials with applications in dentistry. This book provides current research results for those working in an applied setting. The advantage of having all this information in one coherent text will be the focused nature of the chapters and the ease of which this information can be accessed.
This collection of titles brings together many of the novel applications these materials have in biology and discusses the advantages and disadvantages of each application and the perspectives of the technologies based on these findings. At the moment there is no other comparable book series covering all the subjects approached in this set of titles.Offers an updated and highly structured reference material for students, researchers, and practitioners working in biomedical, biotechnological, and engineering fieldsServes as a valuable resource of recent scientific progress, along with most known applications of nanomaterials in the biomedical fieldFeatures novel opportunities and ideas for developing or improving technologies in nanomedicine and dentistry
Often, a generalist approach is followed for the translation of materials and technologies designed for other applications, without considering the specific role of scaffolds from a physical and biological point of view. The book illustrates scaffold design principles, with particular relevance to the biological requirements needed to control and drive the biological cross talk, and reviews materials and fabrication and validation methods.
Provides the FDA, Health Canada, WHO, and EMEA guidelines directly applicable to pharmaceutical laboratory-related issues Offers generic formats and styles that can be customized to any organization and help management build quality into routine operations to comply with regulatory requirements Contains ready-to-use training courses that supply a good source of training material for experienced and inexperienced practitioners in the biotechnology/biopharmaceutical industries Includes a CD with downloadable training courses that can be adopted and directly customized to a particular organization Supplies ready-to-use test papers that allow end users to record all raw data up to the issuance of the attached certificate
The biotechnology/bioscience industries are regulated worldwide to be in compliance with cGMP and GLP principles, with particular focus on safety issues. Each company must create a definite training matrix of its employees. The training procedures in this book enable end users to understand the principles and elements of manufacturing techniques and provide documentation language ranging from the generic to the specific. The training courses on the CD supply valuable tools for developing training matrices to achieve FDA, Health Canada, EMEA, MHRA UK, WHO, and GLP compliance.
While the presence of nonlinear dynamics can be explained and understood, it is difficult to be measured. A study of human movement variability with a focus on nonlinear dynamics, Nonlinear Analysis for Human Movement Variability, examines the characteristics of human movement within this framework, explores human movement in repetition, and explains how and why we analyze human movement data. It takes an in-depth look into the nonlinear dynamics of systems within and around us, investigates the temporal structure of variability, and discusses the properties of chaos and fractals as they relate to human movement.
Providing a foundation for the use of nonlinear analysis and the study of movement variability in practice, the book describes the nonlinear dynamical features found in complex biological and physical systems, and introduces key concepts that help determine and identify patterns within the fluctuations of data that are repeated over time. It presents commonly used methods and novel approaches to movement analysis that reveal intriguing properties of the motor control system and introduce new ways of thinking about variability, adaptability, health, and motor learning.
In addition, this text:
Demonstrates how nonlinear measures can be used in a variety of different tasks and populations Presents a wide variety of nonlinear tools such as the Lyapunov exponent, surrogation, entropy, and fractal analysis Includes examples from research on how nonlinear analysis can be used to understand real-world applications Provides numerous case studies in postural control, gait, motor control, and motor development
Nonlinear Analysis for Human Movement Variabilityadvances the field of human movement variability research by dissecting human movement and studying the role of movement variability. The book proposes new ways to use nonlinear analysis and investigate the temporal structure of variability, and enables engineers, movement scientists, clinicians, and those in related disciplines to effectively apply nonlinear analysis in practice.
The Physical Measurement of Bone provides a detailed description of all the major methods of bone analysis, including brief comments on clinical evaluation. The physics of each method are introduced as well as a summary of practical procedures. The book is essential reading for practicing medical physicists and technicians who need to know about the many methods of bone analysis open to them, and, more importantly, the wide coverage provides a good introductory framework for students of medical physics and biomedical engineering.
Following an introductory section, the book is divided into three sections: the material response to biological systems, host response to biomaterials, and test methods for determining biological response in vitro as well as in animal models and clinical settings.
Supplemental "Interparts" summarize the physical properties of commonly used metallic, polymeric, and ceramic biomaterials. They also provide a guide to understanding the clinical performance of implanted biomaterials.
This book explores the recent advances involved in EEG/ERP analysis for brain monitoring, details successful EEG and ERP applications, and presents the neurological aspects in a simplified way so that those with an engineering background can better design clinical instruments. It consists of 13 chapters and includes the advanced techniques used for signal enhancement, source localization, data fusion, classification, and quantitative EEG. In addition, some of the chapters are contributed by neurologists and neurosurgeons providing the clinical aspects of EEG/ERP analysis.Covers a wide range of EEG/ERP applications with state-of-the-art techniques for denoising, analysis, and classification Examines new applications related to 3D display devices Includes MATLAB® codes
EEG/ERP Analysis: Methods and Applications is a resource for biomedical and neuroscience scientists who are working on neural signal processing and interpretation, and biomedical engineers who are working on EEG/ERP signal analysis methods and developing clinical instrumentation. It can also assist neurosurgeons, psychiatrists, and postgraduate students doing research in neural engineering, as well as electronic engineers in neural signal processing and instrumentation.
What’s New in This Edition:
This edition includes material on modern integrated circuit (IC) and photonic sensors, micro-electro-mechanical (MEM) and nano-electro-mechanical (NEM) sensors, chemical and radiation sensors, signal conditioning, noise, data interfaces, and basic digital signal processing (DSP), and upgrades every chapter with the latest advancements. It contains new material on the designs of micro-electro-mechanical (MEMS) sensors, adds two new chapters on wireless instrumentation and microsensors, and incorporates extensive biomedical examples and problems.
Containing 13 chapters, this third edition:Describes sensor dynamics, signal conditioning, and data display and storage Focuses on means of conditioning the analog outputs of various sensors Considers noise and coherent interference in measurements in depth Covers the traditional topics of DC null methods of measurement and AC null measurements Examines Wheatstone and Kelvin bridges and potentiometers Explores the major AC bridges used to measure inductance, Q, capacitance, and D Presents a survey of sensor mechanisms Includes a description and analysis of sensors based on the giant magnetoresistive effect (GMR) and the anisotropic magnetoresistive (AMR) effect Provides a detailed analysis of mechanical gyroscopes, clinometers, and accelerometers Contains the classic means of measuring electrical quantities Examines digital interfaces in measurement systems Defines digital signal conditioning in instrumentation Addresses solid-state chemical microsensors and wireless instrumentation Introduces mechanical microsensors (MEMS and NEMS) Details examples of the design of measurement systems
Introduction to Instrumentation and Measurements is written with practicing engineers and scientists in mind, and is intended to be used in a classroom course or as a reference. It is assumed that the reader has taken core EE curriculum courses or their equivalents.
Quantifying the amount of autonomic nervous system activity in an individual patient can be extremely important, because it provides a gauge of disease severity in a large number of diseases. Heart rate variability (HRV) calculated from both short-term and longer-term electrocardiograms is an ideal window into such autonomic activity for two reasons: one, heart rate is sensitive to autonomic activity in the entire body, and two, recording electrocardiograms is inexpensive and non-invasive unlike other techniques currently available for autonomic assessment, such as microneurography and metaiodobenzylguanidine (MIBG) scanning. Heart Rate Variability (HRV) Signal Analysis: Clinical Applications provides a comprehensive review of three major aspects of HRV: mechanism, technique, and clinical applications.
Learn Techniques for HRV Signal Analysis
Edited by an engineer, a cardiologist, and a neurologist, and featuring contributions by widely published international researchers, this interdisciplinary book begins by reviewing the many signal processing techniques developed to extract autonomic activity information embedded in heart-rate records. The classical time and frequency domain measures, baroreceptor sensitivity, and newer non-linear measures of HRV are described with a fair amount of mathematical detail with the biomedical engineer and mathematically oriented physician in mind. The book also covers two recent HRV methods, heart-rate turbulence and phase-rectified signal averaging.
Use of HRV in Clinical Care
The large clinical section is a must-read for clinicians and engineers wishing to get an insight into how HRV is applied in medicine. Nineteen chapters altogether are devoted to uses of HRV in:Monitoring—for example to predict potential complications in pregnancies, fetal distress, and in neonatal critical care Acute care—for gauging the depth of anesthesia during surgery and predicting change in patient status in the intensive care unit Chronic disorders—for assessing the severity of congestive heart failure, stroke, Parkinson’s disease, and depression
Bringing together the latest research, this comprehensive reference demonstrates the utility and potential of HRV signal analysis in both the clinic and physiology laboratory.
The book begins with a basic introduction of biotechnology, moves on to more complex topics, and provides relevant examples along the way. Each chapter begins with a brief summary, is illustrated by simple line diagrams, pictures, and tables, and ends with a question session, an assignment, and field trip information. The author also discusses the connection between plant breeding, cheese making, in vitro fertilization, alcohol fermentation, and biotechnology.
Comprised of 15 chapters, this seminal work offers in-depth coverage of topics that include:
Genes and Genomics Proteins and Proteomics Recombinant DNA Technology Microbial Biotechnology Agricultural Biotechnology Animal Biotechnology Environmental Biotechnology Medical Biotechnology Nanobiotechnology Product Development in Biotechnology Industrial Biotechnology Ethics in Biotechnology Careers in Biotechnology Laboratory Tutorials
Biotechnology Fundamentals, Second Editionprovides a complete introduction of biotechnology to students taking biotechnology or life science courses and offers a detailed overview of the fundamentals to anyone in need of comprehensive information on the subject.
Covering everything from sensors, systems, and software to integration, usability, and regulatory challenges, Mobile Point-of-Care Monitors and Diagnostic Device Design offers valuable insight into state-of-the-art technologies, research, and methods for designing personal diagnostic and ambulatory healthcare devices. Presenting the combined expertise of contributors from various fields, this multidisciplinary text:Gives an overview of the latest mobile health and point-of-care technologies Discusses portable diagnostics devices and sensors, including mobile-phone-based health systems Explores lab-on-chip systems as well as energy-efficient solutions for mobile point-of-care monitors Addresses computer vision and signal processing for real-time diagnostics Considers interface design for lay healthcare providers and home users
Mobile Point-of-Care Monitors and Diagnostic Device Design provides important background information about the design process of mobile health and point-of-care devices, using practical examples to illustrate key aspects related to instrumentation, information processing, and implementation.
Tutorials in Radiotherapy Physics: Advanced Topics with Problems and Solutions covers selected advanced topics that are not thoroughly discussed in any of the standard medical physics texts. The book brings together material from a large variety of sources, avoiding the need for you to search through and digest the vast research literature. The topics are mathematically developed from first principles using consistent notation.
Clear Derivations and In-Depth Explanations
The book offers insight into the physics of electron acceleration in linear accelerators and presents an introduction to the study of proton therapy. It then describes the predominant method of clinical photon dose computation: convolution and superposition dose calculation algorithms. It also discusses the Boltzmann transport equation, a potentially fast and accurate method of dose calculation that is an alternative to the Monte Carlo method. This discussion considers Fermi–Eyges theory, which is widely used for electron dose calculations. The book concludes with a step-by-step mathematical development of tumor control and normal tissue complication probability models. Each chapter includes problems with solutions given in the back of the book.
Prepares You to Explore Cutting-Edge Research
This guide provides you with the foundation to read review articles on the topics. It can be used for self-study, in graduate medical physics and physics residency programs, or in vendor training for linacs and treatment planning systems.
Each chapter begins with a brief review of the advances in computational efforts in the selected topic area and ends with case studies with detailed technical information. The approach provides a relevant overview of the selected topic area and demonstrates, with case studies, the power of computational modeling in offering predictive capabilities to assess new surgical concepts and medical devices and post-operative surgical outcomes. The book illustrates the expanded capabilities of computational bioengineering through discussions of bioengineering problems and discusses an image-based bioengineering modeling technique.
Although computer modeling has been used to tackle bioengineering problems for decades, a systematic study of computational bioengineering not only addresses many critical challenges facing bioengineering but also sets a new direction for advancing the field. In a long run, this book is expected to foster an integrative problem-solving mentality that will help you generate new and novel solutions to future biomedical problems.
What’s new in the Fifth Edition?
· A new chapter on the human visual process that explains which visual cues elicit a response from the viewer
· Description of the latest hardware and software for image acquisition and printing, reflecting the proliferation of the digital camera
· New material on multichannel images, including a major section on principal components analysis
· Expanded sections on deconvolution, extended dynamic range images, and image enlargement and interpolation
· More than 600 new and revised figures and illustrations for a total of more than 2000 illustrations
· 20% more references to the most up-to-date literature
Written in a relaxed and reader-friendly style, The Image Processing Handbook, Fifth Edition guides you through the myriad tools available for image processing and helps you understand how to select and apply each one.
Despite its importance, most books on ultrasonics cover only very specific sub-fields of the science. They generally also take a more mathematical approach and lack the wider scope needed to truly improve understanding and facilitate practical use of ultrasonics across a wide range of disciplines.
Create Efficient Systems for Any Environment
Ultrasonics Data covers the science, technology, and application of ultrasonics. It discusses everything from sensors to systems, dealing primarily with both low- and high-intensity industrial and medical ultrasonic applications. It presents data and functions from different areas of science and technology to help readers better comprehend and more effectively use ultrasound energy. Starting with relevant basic ultrasonic equations, the authors explore the application of finite elements to the design of vibrating bars, horns, plates, rings, large horns, and blades. They analyze properties and design data applicable to piezoelectric materials and transducers, as well as magnetostrictive, pneumatic, and liquid transducers. The book examines the mechanical and physical properties of materials, including those necessary for welding and forming. Using practical applications, the book explores the chemical properties and compatibilities of materials, and the chemical effects of ultrasound. There is also information on nondestructive testing applications and the modern equipment used to carry them out, including electromagnetic acoustic transducers (EMATs) and lasers.
A "Big-Picture" Focus on Practical Data and Principles
Versatile as a reference for engineers, researchers, and graduate students, this book summarizes the history of ultrasonics, projects future advances, and evaluates the practicality of new ideas. Helping system designers meet the requirements of present and future developments, it covers a range of applications to inspire new innovations using ultrasonics.
The book describes a new generation of microfluidic biochips with more complex designs that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance. Part I describes a unified design methodology that targets design optimization under resource constraints. Part II investigates cost-effective testing techniques for digital microfluidic biochips that include test resource optimization and fault detection while running normal bioassays. Part III focuses on different reconfiguration-based defect tolerance techniques designed to increase the yield and dependability of digital microfluidic biochips.
Expanding upon results from ongoing research on CAD for biochips at Duke University, this book presents new design methodologies that address some of the limitations in current full-custom design techniques. Digital Microfluidic Biochips is an essential resource for achieving the integration of microfluidic components in the next generation of system-on-chip and system-in-package designs.
From the underlying principles to practical applications, this updated edition of Biomedical Sensors and Instruments provides an easy-to-understand introduction to the various kinds of biomedical sensors. The book presents state-of-the-art discussions of sensors for the measurements of pressure, flow, motion, temperature, heat flow, evaporation, biopotential, biomagnetism, and chemical quantities.
Each controversial topic in modern medicine and ethics is introduced through a hypothetical case study that highlights thorny ethical issues before explaining the key aspects of the science and technology involved and addressing the associated ethical considerations in detail. The interdisciplinary treatment of the topics makes the book relevant to students of science, medicine, ethics, law, and sociology as well as health care professionals.
After providing a brief introduction, the book describes the models for AT service delivery, the design tools and principles of universal design, and various technology-transfer mechanisms, models, and principles. The text then explains the process for creating assistive device standards, followed by a review of seating biomechanics and soft tissue biomechanics. Subsequent chapters examine design and service delivery principles of wheelchairs and scooters, functional electrical stimulation and its applications, wheelchair-accessible transportation legislation, and the applications of robotics in medical rehabilitation. The book proceeds to discuss prosthetic and orthotic design and usage, visual and hearing impairment, Web-related AT, and augmentative and alternative communication (AAC) technology. It concludes with an introduction to adaptive sports and recreation.
Incorporating the critical aspects of RE and AT, An Introduction to Rehabilitation Engineering focuses on the principles, modeling, standards, devices, and technologies of RE and AT. It presents a concise yet complete overview of RE to provide a solid foundation in the subject as well as to stimulate further study.
Analyzing major topics and disciplines in this arena, this volume:
Defines scope, current status, and future prospects of nanobiomaterials Surveys nanobiomaterials and examines various synthesis and processing techniques important for developing nanobiomaterials Explores the unique nanoscopic physicochemical properties of nanobiomaterials Discusses potential applications, emphasizing unique challenges in the design, fabrication, and evaluation of biomaterials for a particular application or field Provides a detailed overview of the interactions between bionanomaterials/biological systems and the biocompatibility issues associated with bionanomaterials
Advances in nanobiomaterials requires a multidisciplinary approach spanning major fields in physical and biological sciences, engineering, and medicine with considerable collaboration between ethicists, regulatory bodies, and industry. This volume brings together the work of a team of world-renowned experts from various fields who discuss the vast potential for nanobiomaterials in a myriad of applications.
This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and other emerging technologies –such as brain-machine interfaces for controlling bionics and neuroprostheses– is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production. The result is a comprehensive textbook that will be useful to students and experts alike.Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valvesOffers expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systemsFull-color presentation throughout
Part one reviews basic principles for the culture of stem cells before discussing technologies for particular cell types. These include human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells. Part two discusses wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies. The final part of the book considers the therapeutic use of stem and progenitor cells. Chapters review the use of adipose tissue-derived stem cells, umbilical cord blood (UCB) stem cells, bone marrow, auditory and oral cavity stem cells. Other chapters cover the use of stem cells in therapies in various clinical areas, including lung, cartilage, urologic, nerve and cardiac repair.
With its distinguished editor and international team of contributors, Progenitor and stem cell technologies and therapies is a standard reference for both those researching in cell and tissue biology and engineering as well as medical practitioners investigating the therapeutic use of this important technology.Reviews the range of progenitor and stem cells available and outlines their therapeutic applicationExamines the basic principles for the culture of stem cells before discussing technologies for particular cell types, including human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cellsIncludes a discussion of wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies
An ambitious and unparalleled project, this pioneering work is the result of several years of planning and preparation involving 64 authors from across the world. It brings together recommendations and information sanctioned by the International Commission on Radiological Protection (ICRP) and documents 40 years of history and the progress of those involved with cutting-edge work with Monte Carlo Codes and radiation protection dosimetry. This volume was in part spurred on by the ICRP’s key decision to adopt voxelized computational phantoms as standards for radiation protection purposes. It is an invaluable reference for those working in that area as well as those employing or developing anatomical models for a a number of clinical applications.
Assembling the work of nearly all major phantom developers around the world, this volume examines:
The history of the research and development in computational phantoms Detailed accounts for each of the well-known phantoms, including the MIRD-5, GSF Voxel Family Phantoms, NCAT, UF Hybrid Pediatric Phantoms, VIP-Man, and the latest ICRP Reference Phantoms Physical phantoms for experimental radiation dosimetry
The smallest voxel size (0.2 mm), phantoms developed from the Chinese Visible Human Project
Applications for radiation protection dosimetry involving environmental, nuclear power plant, and internal contamination exposuresMedical applications, including nuclear medicine therapy, CT examinations, x-ray radiological image optimization, nuclear medicine imaging, external photon and proton treatments, and management of respiration in modern image-guided radiation treatment Patient-specific phantoms used for radiation treatment planning involving two Monte Carlo code systems: GEANT4 and EGS Future needs for research and development
Related data sets are available for download on the authors’ website. The breadth and depth of this work enables readers to obtain a unique sense of the complete scientific process in computational phantom development, from the conception of an idea, to the identification of original anatomical data, to solutions of various computing problems, and finally, to the ownership and sharing of results in this groundbreaking field that holds so much promise.
Few people know much about stem cell research beyond the ethical questions raised by using embryos. But in the last decade, stem cell research has made huge advances toward eliminating some of our most intractable diseases. Now this sweeping and accessible book introduces us to this cutting-edge science that will revolutionize medicine and change the way we think about and treat disease.
Alice Park takes us from stem cell's controversial beginnings to the recent electrifying promise of being able to create the versatile cells without using embryos at all. She shows us how stem cells give researchers an unprecedented ability to study disease while giving patients the promise of replacing diseased cells with healthy new ones. And she profiles the scientists and leaders-many with their own compelling stories-who have fueled the quest and will continue to shape the field in years to come.
The book includes a variety of techniques that are conducting biosensors as transducers. The single die has all of the biosensors implemented within it, which leads to a new generation of multibiosensors named as multi-labs-on-a-single chip (MLoC). Biosensors are analytical devices that combine a biologically sensitive element with a physical or chemical transducer to detect the presence of specific compounds selectively and quantitatively. This book explores the feasibility of microelectronic techniques in a successful attempt to get huge cost savings in mass production, fast reacting, and disposable biosensors. The book is lied in six chapters and four appendices. These sensors were implemented using CMOSP35 technology on a single-chip that covers new techniques for detecting biomedical and biological samples at low concentration level based on CMOS/MEMS technology batch process. The methodology of the proposed multibiosensors that is named by multi-lab-on-a-chip (MLoC); lies on miniaturizing transducers, which is based on optical CMOS technology, charge based capacitance measurements (CBCM), electrochemical impedance spectroscopy (EIS) and CMOS microcoils incorporating with interdigitated microelectrode array (IDMA). The aforementioned approaches technically proved their capability and reliability overwhelmingly among the used conventional techniques for that reason these techniques have been proposed to create compact and portable biosensors for sensitive and rapid detection of biomedical and biological samples. While the four proposed biosensors have common objectives they differ in the method and analysis used, and postulates engaged by a discipline to achieve the objectives; the inquiry of the principles of investigation in a particular field.
The book has been carefully designed to be concise and visually, easily read in one sitting or perused from one section to another as needed It begins with a review of human factors engineering and how usability testing fits in, and then discusses the government regulations and industry standards that have motivated many medical device manufacturers to conduct usability tests. It then covers the nitty-gritty of planning, conducting, and reporting the results of a usability test, making the process as smooth and painless as possible for the development team, and therefore making the medical devices they develop as safe, effective, and appealing as possible.
As you read the book, keep in mind that, like snowflakes, each usability test is unique. And while 100 usability specialists working independently might take 100 different approaches to testing, albeit with considerable methodological overlap, there would also be meaningful differences that the practitioners would energetically defend as the best given the circumstances. To make your testing process easier, the authors, seasoned human factors specialists who have conducted thousands of test sessions involving medical devices used by physicians, nurses, therapists, technicians, and patients, have painstakingly put together an informative, practical, and engaging handbook for conducting usability tests of medical devices.
This second edition updates previous topics and features many new chapters describing novel approaches that promise to replace drugs or surgery because they are more effective and much safer, such as rTMS for depression, MRI-Guided Focused Ultrasound for bone and uterine tumors, and TheraBionic LEET for liver cancer.
Others discuss biological water (H3O2) that acts like a battery, health benefits of Earthing, malignant and other brain tumors from cell and cordless phones, visualizing and measuring energy fields in humans and nature, making sense of homeopathy and "memory of water," basic science support for acupuncture, electrosensitivity, ion cyclotron resonance, the role of the pineal gland, the health effects of solar storms and terrestrial influences, and why Bioelectric Resonance Therapy bridges Chinese and Western medicine.
This is only a sampling of the 50 chapters contributed by authorities from the United States, Europe, Scandinavia, Russia, China, Japan, and Iran.
The Handbook of Research on Biomedical Engineering Education and Advanced Bioengineering Learning: Interdisciplinary Concepts explores how healthcare practices have been steered toward emerging frontiers, including, among others, functional medical imaging, regenerative medicine, nanobiomedicine, enzyme engineering, and artificial sensory substitution. From comprehensive descriptions of state-of-the-art educational programs to a methodical treatment of the latest advancements, this two-volume handbook provides a solid point of reference necessary for establishing further research in this life-saving field.
Table of Contents: Structure-Function Relationships of the Knee Meniscus / Pathophysiology and the Need for Tissue Engineering / Tissue Engineering of the Knee Meniscus / Current Therapies and Future Directions
Details procedures utilized by leading companies to successfully meet FDA and end-user requirements, manufacture high-quality products, and improve and generate profit.
Design Controls for the Medical Device Industry contains valuable guidelines that enable readers to
prepare for an FDA audit
identify consumer needs, resolve project objectives, and process inconsistencies and discrepancies
determine the compatibility of design specifications and manufacturing, installation, and servicing demands
ensure that proper design, function, and performance stipulations are understood and met
verify and validate design criteria and production schemes
eliminate confusion and prevent communication breakdowns
allocate and conserve resources
perform risk assessment analyses
predict potential hazards under normal and fault conditions
Presenting blueprints for the application, evaluation, and refinement of quality assurance and performance practices-from product launch through engineering and assembly-Design Controls for the Medical Device Industry is a clear and indispensable source for biomedical, quality assurance, reliability, software, product design, manufacturing, research and development, and industrial engineers; project directors and managers; biomedical technicians; and upper-level undergraduate and graduate students in these disciplines.
Nancy N. Chen
Phuoc V. Le
Kaushik Sunder Rajan