Filling the void, Biotechnology Operations: Principles and Practices reflects this integrative philosophy, serving as a practical guide for students, professionals, or anyone else with interests in the biotech industry. Although many books emphasize specific technical aspects of biotech, this is perhaps the first to integrate essential concepts of product development and scientific and management skills with the seven functional areas of biotechnology:
Biomanufacturing Clinical trials Nonclinical studies Project management Quality assurance Quality control Regulatory affairs
A practical roadmap to optimizing biotechnology operations, this reference illustrates how to use specific product planning, design, and project management processes to seamlessly merge plans and efforts in the key functional areas. Applying lessons learned throughout the nascent history of biotech, author Michael Roy highlights developmental principles that could bring future products to market more safely and efficiently. Drawing from his experiences working in industry and teaching a graduate course at the University of Wisconsin, this hotly anticipated book clarifies basic methodologies and practices to help reduce risks and resolve problems as future technological discoveries are developed into tangible products.
This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and other emerging technologies –such as brain-machine interfaces for controlling bionics and neuroprostheses– is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production. The result is a comprehensive textbook that will be useful to students and experts alike.Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valvesOffers expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systemsFull-color presentation throughout
Christine Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer’s yeast, is regarded as one of the most brilliant new minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metabolic pathway engineering. With a wealth of cutting edge research and analysis, this work also serves as an invaluable resource for those seeking to add their own contributions. Organized by topic, this 3000 page reference is available as two volumes that can be purchased individually or as a set.
The book includes a variety of techniques that are conducting biosensors as transducers. The single die has all of the biosensors implemented within it, which leads to a new generation of multibiosensors named as multi-labs-on-a-single chip (MLoC). Biosensors are analytical devices that combine a biologically sensitive element with a physical or chemical transducer to detect the presence of specific compounds selectively and quantitatively. This book explores the feasibility of microelectronic techniques in a successful attempt to get huge cost savings in mass production, fast reacting, and disposable biosensors. The book is lied in six chapters and four appendices. These sensors were implemented using CMOSP35 technology on a single-chip that covers new techniques for detecting biomedical and biological samples at low concentration level based on CMOS/MEMS technology batch process. The methodology of the proposed multibiosensors that is named by multi-lab-on-a-chip (MLoC); lies on miniaturizing transducers, which is based on optical CMOS technology, charge based capacitance measurements (CBCM), electrochemical impedance spectroscopy (EIS) and CMOS microcoils incorporating with interdigitated microelectrode array (IDMA). The aforementioned approaches technically proved their capability and reliability overwhelmingly among the used conventional techniques for that reason these techniques have been proposed to create compact and portable biosensors for sensitive and rapid detection of biomedical and biological samples. While the four proposed biosensors have common objectives they differ in the method and analysis used, and postulates engaged by a discipline to achieve the objectives; the inquiry of the principles of investigation in a particular field.
Few people know much about stem cell research beyond the ethical questions raised by using embryos. But in the last decade, stem cell research has made huge advances toward eliminating some of our most intractable diseases. Now this sweeping and accessible book introduces us to this cutting-edge science that will revolutionize medicine and change the way we think about and treat disease.
Alice Park takes us from stem cell's controversial beginnings to the recent electrifying promise of being able to create the versatile cells without using embryos at all. She shows us how stem cells give researchers an unprecedented ability to study disease while giving patients the promise of replacing diseased cells with healthy new ones. And she profiles the scientists and leaders-many with their own compelling stories-who have fueled the quest and will continue to shape the field in years to come.
Biological drug products play a central role in combating human diseases; however, developing new successful biological drugs presents many challenges, including labor intensive production processes, tighter regulatory controls, and increased market competition. This book reviews the current state of the science, offering readers a single resource that sets forth the fundamentals as well as tested and proven development strategies for biological drugs. Moreover, the book prepares readers for the challenges that typically arise during drug development, offering straightforward solutions to improve their ability to pass through all the regulatory hurdles and deliver new drug products to the market.
Biological Drug Products begins with general considerations for the development of any biological drug product and then explores the strategies and challenges involved in the development of specific types of biologics. Divided into five parts, the book examines:Part 1: General Aspects Part 2: Proteins and Peptides Part 3: Vaccines Part 4: Novel Biologics Part 5: Product Administration/Delivery
Each chapter has been prepared by one or more leading experts in biological drug development. Contributions are based on a comprehensive review and analysis of the current literature as well as the authors' first-hand experience developing and testing new drugs. References at the end of each chapter serve as a gateway to original research papers and reviews in the field.
By incorporating lessons learned and future directions for research, Biological Drug Products enables pharmaceutical scientists and students to improve their success rate in developing new biologics to treat a broad range of human diseases.
The author’s continual participation in FDA QSR inspections and Notified Body ISO audits is reflected in updates to all chapters and appendices of the book, now bursting at the seams with:
New coverage of ISO 9001 and 13485 design control requirements More real-world examples from the medical device industry Additional detail for greater understanding and clarity Fresh templates for practical implementation Extensive references for further study
The book addresses design control elements such as design planning, input, output, review, verification, validation, change, transfer, and history, as well as risk management inclusive of human factors and usability, biocompatibility, the FDA Quality System Inspection Technique (QSIT) for design controls, and medical device regulations and classes in the US, Canada, and Europe.
Discussing the relationship between mechanical loading, function, and biological performance, it first reviews basic structure-function relationships for most major orthopedic tissue types followed by the most-relevant structures of the body. It then addresses multiscale modeling and biologic considerations. It concludes with a look at applications of biomechanics, focusing on recent advances in theory, technology and applied engineering approaches.
With contributions from leaders in the field, the book presents state-of-the-art findings, techniques, and perspectives. Much of orthopaedic, biomechanical, and biomedical engineering research is directed at the translational capabilities for the "real world". Addressing this from the perspective of diagnostics, prevention, and treatment in orthopaedic biomechanics, the book supplies novel perspectives for the interdisciplinary approaches required to translate orthopaedic biomechanics to today’s real world.
Topics covered include:
Patterning of biomimetic substrates with AFM lithography, primarily focusing on DPN Nanotemplating polymer melts Nanotechnology-based approaches in the treatment of injuries to tendons and ligaments Progress in the use of electrospinning processing techniques for fabricating nanofiber scaffolds for neural applications Nanotopography techniques for tissue-engineered scaffolds and the effects of nanotopography on cells and tissues Vertically aligned TiO2 nanotube surface structuring for optimization of Ti implants utilizing nanotechnology Applications originating from the harmony of nanotechnology to biological systems, especially for the regeneration in the nervous system Current understanding of the mechanisms by which cells sense nano-scale structure at the molecular level and how this understanding can be useful in developing novel antifouling materials
While there are books available on tissue engineering and nanotechnology and others about regenerative medicine, most do not comprehensively cover applications of nanotechnology to both these areas. Focusing chiefly on drug delivery, tissue engineering, and regenerative medicine, the book uses an application-based approach to relate laboratory-based research to the development of technologies that can be readily adaptable to an industrial environment.
The analysis is cast in various contexts and examined at multiple levels. The first deals with the Eurocentric character of the patent system, international law, and institutions. The second involves the cultural and economic dichotomy between the industrialized Western world and the westernizing, developing world. The third level of analysis considers the phenomenal loss of human cultures and plant diversity. Exhaustively researched and eloquently argued, Global Biopiracy sheds new light on a contentious topic. The impact of intellectual property law on indigenous peoples and informal or traditional innovations is a field of study that currently includes only a handful of scholars. Biopiracy will be an invaluable resource for students, teachers, and legal practitioners.
Part one reviews basic principles for the culture of stem cells before discussing technologies for particular cell types. These include human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells. Part two discusses wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies. The final part of the book considers the therapeutic use of stem and progenitor cells. Chapters review the use of adipose tissue-derived stem cells, umbilical cord blood (UCB) stem cells, bone marrow, auditory and oral cavity stem cells. Other chapters cover the use of stem cells in therapies in various clinical areas, including lung, cartilage, urologic, nerve and cardiac repair.
With its distinguished editor and international team of contributors, Progenitor and stem cell technologies and therapies is a standard reference for both those researching in cell and tissue biology and engineering as well as medical practitioners investigating the therapeutic use of this important technology.Reviews the range of progenitor and stem cells available and outlines their therapeutic applicationExamines the basic principles for the culture of stem cells before discussing technologies for particular cell types, including human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cellsIncludes a discussion of wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies
The Handbook of Research on Biomedical Engineering Education and Advanced Bioengineering Learning: Interdisciplinary Concepts explores how healthcare practices have been steered toward emerging frontiers, including, among others, functional medical imaging, regenerative medicine, nanobiomedicine, enzyme engineering, and artificial sensory substitution. From comprehensive descriptions of state-of-the-art educational programs to a methodical treatment of the latest advancements, this two-volume handbook provides a solid point of reference necessary for establishing further research in this life-saving field.
* Provides quick access to the primary literature in this field
* Reviews studies of titanium materials in medical and dental applications, as reported in nearly 1,500 articles published over last several years
* Draws information from several types of studies and reports
* Helps readers answer questions about the most appropriate materials and when to use them
This second edition updates previous topics and features many new chapters describing novel approaches that promise to replace drugs or surgery because they are more effective and much safer, such as rTMS for depression, MRI-Guided Focused Ultrasound for bone and uterine tumors, and TheraBionic LEET for liver cancer.
Others discuss biological water (H3O2) that acts like a battery, health benefits of Earthing, malignant and other brain tumors from cell and cordless phones, visualizing and measuring energy fields in humans and nature, making sense of homeopathy and "memory of water," basic science support for acupuncture, electrosensitivity, ion cyclotron resonance, the role of the pineal gland, the health effects of solar storms and terrestrial influences, and why Bioelectric Resonance Therapy bridges Chinese and Western medicine.
This is only a sampling of the 50 chapters contributed by authorities from the United States, Europe, Scandinavia, Russia, China, Japan, and Iran.
Author Jack Anderson was a caregiver to four women in his life who went through breast cancer. It was then that he realized that all his experiences, combined with the journeys of other caregivers through “Cancer Land,” needed to be told. So he wrote Stand by Her: A Breast Cancer Guide for Loved Ones, which talks directly to caregivers, and offers strategies and support on the countless minefields they will face, every day, as husbands, partners, daughters, sons, sisters, brother, mothers, fathers, nieces, nephews, friends, and coworkers of breast cancer patients before, during, and after her treatment.
Throughout the book, Anderson combines his own personal stories with accounts from other caregivers, along with detailed advice from experts who address all the medical, emotional, physical, psychological, family relationship, sexual, and financial issues. Each chapter focuses on each stage of the breast cancer process, framed with its own unique color, to symbolize what the reader and their loved one are going through.
When a loved one has cancer, family and friends are at a loss about what to do and how to do it, and are left with all the best of intentions and nowhere to go. Stand by Her fills that gap and is a great go-to resource for anyone who has a loved one facing a cancer diagnosis and treatment.Penny Damaskos, PhD, LCSW, OSW-C
Director, Department of Social Work
Memorial Sloan Kettering Cancer Center
I have read dozens of books on breast cancer and written one myself, but Stand by Her is unique, written by a man who has helped four separate women deal with their breast cancer experiences. It goes without saying that caregivers and loved ones should go out and "Stand by Her."
Barron H. Lerner, MD, PhD
Professor of Medicine, NYU and author of The Breast Cancer Wars
Jack Anderson offers invaluable perspective on how breast cancer becomes a family journey. An incredible resource for all who have been touched by breast cancer.
Dr Holly Phillips, MD, General Internist, NY, NY
Chapters reflect the experience of all three authors who have successfully applied the algorithm for better patient management as well as decreased wastage of expensive blood products, from both the clinical laboratory/pathology and clinical medicine perspective. This book will appeal to a broad section of clinical laboratory and medical practitioners from hematopathology, to internal medicine, surgery, and anesthesiology. For hematopathologists and pathologists who are involved in laboratory medicine and transfusion medicine, this book will help them understand the proper utilization of blood products and how to avoid unnecessary waste and costs for the hospital. For general surgery practitioners, this book will provide practical guidelines on how to use blood products rationally for best medical practice. Internists will also gain insight from this book, learning which patients are at higher risk of bleeding during surgery so that they can alert their clinical colleagues.Focuses on the clinical tests that may be done during preoperative assessment, intraoperative, and postoperative assessment and managementExplains new decision-support software developed by the authors as a tool for the management of bleeding patientsReviews common coagulation based tests (indication and interpretation) that are used to assist in the management of bleeding patientsProvides an overview of various blood products, pharmacotherapeutic agents, antiplatelets, and anticoagulants, their usage strategy, indications, and therapy goals
Incorporating multidisciplinary work in applied mathematics, statistics, and animal and human experiments at the forefront of the field, the book addresses the use of time series data in brain connectivity interference studies. Contributors present codes and data examples to back up their methodological descriptions, exploring the details of each proposed method as well as an appreciation of their merits and limitations. Supplemental material for the book, including code, data, practical examples, and color figures is supplied in the form of a CD with directories organized by chapter and instruction files that provide additional detail.
The field of brain connectivity inference is growing at a fast pace with new data/signal processing proposals emerging so often as to make it difficult to be fully up to date. This consolidated panorama of data-driven methods includes theoretical bases allied to computational tools, offering readers immediate hands-on experience in this dynamic arena.
New chapters on nonlinear and complex systems
Enriched with many examples that promote sound practical analysis, this volume covers classical linear systems theory and its applications to biomedicine. It examines the important use of joint time-frequency analysis to characterize non-stationary physiological signals, and explores the mathematics of tomographic imaging (the Radon transform, the Fourier slice theorem, and the filtered back-projection algorithm). It also describes the analytical signal and the Hilbert transform and some of its biomedical applications. New chapters in this edition include one on the analysis of nonlinear biochemical systems and biochemical oscillators, as well as one introducing complex systems and illustrating ways to best model them.
Four appendices with additional material
Extensive appendices supplement the text, including "Simnon® Programs Used in Chapters 11 and 12," "How to use Root Locus to Determine the Stability of SISO Linear Systems," "Signal Flow Graphs and Mason’s Rule," and "Computational Tools for Biomedical Signal Processing and Systems Analysis." An extensive glossary is included as well as an ample listing of sources for further study.
A solutions manual is available for instructors wishing to convert this refrence to classroom use.
Biomechanics of the Upper Limbs: Mechanics, Modeling and Musculoskeletal Injuries, Second Edition offers vital information and tools to improve analysis of external forces and their effects on the human body. This can help ergonomists better understand job stressors and the role they play in the development of disorders, enabling them to modify the work environment and educate practitioners to better control harmful situations.
Using the author’s medical and engineering expertise to distill essential subject matter and useful technical data, this comprehensive text explores:
Biomechanics of the upper limbs and the motor control system The structure and physiology of the human musculoskeletal and neuromuscular systems Recent research findings and solutions to various ergonomic problems Models of various components of the neuromuscular systems, as well as larger systems in the upper limbs Risk factors for disorders and tools used to identify their causes
Designed as a textbook for a typical semester-long graduate-level engineering or kinesiology course, this book includes a link to an ancillary website that offers materials such as PowerPoint® slides, sample exams, and an instructor's manual with complete solutions. It also serves as a practical, up-to-date, engineering-oriented resource for researchers, industrial ergonomists, industrial hygienists, and medical professionals who require supplementary material.
Written by leading scientists, the book focuses on the bio-interaction of nano materials, covering various techniques and tests which have been developed to evaluate the toxicity of materials at the nano level. The book highlights the challenges of bio-interactions of nano materials and possible solutions to those challenges. It addresses the assessment and characterization of nano systems in bio-environments, toxicity and bio-sensing devices for toxicity assessment, carbon nano tubes and pulmonary toxicity, and nano toxicity of solid lipid nanoparticles. It also discusses nano safety concerns and solutions, including the effects of nano particles on different organs and regulatory implications of nano materials.
These particles may be used to encapsulate drugs, recognize biological markers, or visualize body tissues among many other possibilities, all enabling their widespread application in biology, medicine, and pharmaceutics. Indeed, these nano materials may have beneficial effects that have not even been imagined. This book gives you an understanding of the safety issues, how to assess for them, and how to mitigate them to move forward in research and development of new applications for nano materials.
This book provides a comprehensive view of bioadhesion and highlights different aspects of this phenomenon. The first section of the book presents fundamentals aspects of bioadhesion. It also summarizes various direct and indirect methods used to investigate and characterize bioadhesion. The second section describes studies of natural adhesives. These include "wet" adhesives that are produced and secreted by sessile marine organisms such as mussels and sand tubes and "dry" adhesives such as the one characterizing the gecko foot. The third section focuses on biomimetic adhesives. These man-made materials are fabricated on the basis of the lessons learned from nature emphasizing the correlation between nature understanding and biomimetics. Finally, the last section reviews medical applications of adhesive materials, which include surgical sealants, mucoadhesive drug delivery vehicles, and prevention of adhesion on medical devices.
What’s New in the Second Edition:
In the second edition, the new material includes regeneration, hybrid and replant materials, tissue engineering, electrical stimulation for tissue growth and repair, modeling of material behavior in service, and long-term function of materials in patients. It explores tools for non-destructive and destructive analysis of explanted devices, and provides updates on all material classes including shape memory and degradable alloys, fracture-resistant ceramics, and bioabsorbable polymers. It provides a compendium for implant host response including in-depth discussion of metallosis and hypersensitive response. It also adds new case studies, worked problems, and a complete self-evaluation test with annotated answers.
Includes focused, practical study questions after each chapter Presents extensive, detailed figures accompanying example problems and concepts Provides a one-stop reference for understanding all biomaterials that are used in contemporary orthopaedic surgery and beyond Introduces key concepts of relevance in each chapter
Orthopaedic Biomaterials in Research and Practice, Second Edition serves as a textbook for orthopaedic residents. It can also serve as a review for the Orthopaedists In-Training Examination (OITE), the Orthopaedic Self-Assessment Examination, or the Orthopaedic Board Examination.
The authors begin with an overview of signal processing and machine learning approaches and continue on to introduce specific applications, which illustrate CI’s importance in medical diagnosis and healthcare. They provide an extensive review of signal processing techniques commonly employed in the analysis of biomedical signals and in the improvement of signal to noise ratio. The text covers recent CI techniques for post processing ECG signals in the diagnosis of cardiovascular disease and as well as various studies with a particular focus on CI’s potential as a tool for gait diagnostics.
In addition to its detailed accounts of the most recent research, Computational Intelligence in Biomedical Engineering provides useful applications and information on the benefits of applying computation intelligence techniques to improve medical diagnostics.
This book is the first textbook in robotic surgery to discuss the integration of smart multifunctional soft and biomimetic materials with robotic end effectors to provide haptic and tactile feedback to surgeons during robotic surgery. It is also the first textbook in robotic surgery that comes with a solutions manual, which makes it useful as a supplement to faculty members teaching many different programs and courses such as robotics, medical devices, surgical interventions, and many more.
This book can be adapted by professors to teach graduate students and researchers, to enable them to further employ their creativity and knowledge, and to undergraduates to enable them to get an excellent grasp of this exciting field. It is also useful for individuals interested in the field for self-study. The background required for this book is college-level mathematics, matrix analysis, geometry, and medical/surgical terminologies.
Comprehensive chapters encompass well-defined methodology that describes the instruments and their corresponding applications in different scientific fields. The book covers optical and electron microscopy; micrometry, especially in microbial taxonomy; pH meters and oxygen electrodes; chromatography for separation and purification of products from complex mixtures; spectroscopic and spectrophotometric techniques to determine structure and function of biomolecules; preparative and analytical centrifugation; electrophoretic techniques; x-ray microanalysis including crystallography; applications of radioactivity, including autoradiography and radioimmunoassays; and fermentation technology and subsequent separation of products of interest.
The book is designed to serve a wide range of students and researchers in diversified fields of life sciences: pharmacy, biotechnology, microbiology, biochemistry, and environmental sciences. It introduces different aspects of basic experimental methods and instrumentation. The book is unique in its broad subject coverage, incorporating fundamental techniques as well as applications of modern molecular and proteomic tools that are the basis for state-of-the-art research. The text emphasizes techniques encountered both in practical classes and in high-throughput environments used in modern industry. As a further aid to students, the authors provide well-illustrated diagrams to explain the principles and theories behind the instruments described.
In Mobile Telemedicine: A Computing and Network Perspective, noted computer scientists Yang Xiao and Hui Chen examine those computing and networking dilemmas arising from wireless and mobile telemedicine. Comprised of the contributions of many prominent international researchers, the book discusses the relative merits and limitations of the existing technology and sheds light on future developments. It begins with a discussion of patient care and monitoring through items such as personal alarm systems. It then reviews the current methods available to monitor cardiac and diabetic patients, analyzes the security and privacy considerations that arise with respect to the transmission of sensitive information, and examines issues relating to networking support. Finally, it concludes with a section on the opportunities and challenges faced by those involved at this intersection of healthcare and communications.
By bridging the fields of medicine and information technology, this volume serves as a useful springboard for those pioneering IT researchers looking for a comprehensive reference. The book also provides information for those involved with either communications or healthcare who want to learn about the current state and potential use of this technology.
Engineered nanobiomaterials, designed from organic or inorganic raw materials, offer promising alternatives in many biomedical applications. In this book, eminent researchers from around the world discuss the various applications, including antibacterial therapy, biosensors, cancer therapy, stimuli-responsive drug release, drug delivery, gene therapy and visual prostheses. In each case, advantages, drawbacks and future potential are outlined.
This book will be of interest to students, postdoctoral researchers and professors engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians.An up-to-date and highly structured reference source for students, researchers and practitioners working in biomedical, biotechnological and engineering fieldsA valuable guide to recent scientific progress, covering major and emerging applications of nanomaterials in the biomedical fieldProposes novel opportunities and ideas for developing or improving engineering technologies in nanomedicine/nanobiology
In this book, leading researchers from around the world share their expertise and unique insights. The book covers the fabrication methods of platforms for multimodal and combinatorial therapeutic options, along with simultaneous and real-time cancer imaging, and innovative approaches for oncology by passive or active pathways of multifunctional nanocarriers. The work also classifies and discusses engineered nanobiosystems for cancer therapy, prevention, and low cancer recurrence or relapse.
This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians.A comprehensive resource for researchers, practitioners and students working in biomedical, biotechnological and engineering fieldsA valuable guide to recent scientific progress and the latest application methodsDiscusses novel opportunities and ideas for developing or improving technologies in nanomedicine and nanobiology
The clinical application of these therapeutic peptides and proteins is limited by several problems, such as lack of physical and chemical stability or the lack of desirable attributes for adequate absorption or distribution. Thus, as these therapeutic peptides and proteins are made available, it will be essential to formulate these drugs into safe, stable, and efficacious delivery systems. The pharmaceutical scientist involved in this effort needs to call upon the knowledge of several disciplines, such as pharmaceutics, medicinal chemistry, biochemistry, microbiology, and chemical engineering and needs to keep abreast with the latest research in the published literature.
Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Third Editionprovides a comprehensive overview of the field for scientists in industry and academia and for students, while also providing practical information on the challenges facing the formulation and delivery aspects of these unique macromolecules. In particular, the book:
Explains how recombinant DNA techniques now allow us to produce therapeutic proteins in a commercially viable form Discusses the physical and chemical pathways of peptide and protein degradation Includes a detailed discussion of protein formulation and lyophilization Overviews the pharmacokinetic aspects of therapeutic peptides and proteins and discusses controlled delivery systems for parenteral administration, including microsphere formulations Discusses research progress on oral, transdermal, mucosal, and topical delivery systems discusses transdermal and topical delivery
Helping to educate the new generation of engineers and biologists, Introduction to BioMEMS explains how certain problems in biology and medicine benefit from and often require the miniaturization of devices. The book covers the whole breadth of this dynamic field, including classical microfabrication, microfluidics, tissue engineering, cell-based and noncell-based devices, and implantable systems. It focuses on high-impact, creative work encompassing all the scales of life—from biomolecules to cells, tissues, and organisms.
Brilliant color presentation
Avoiding the overwhelming details found in many engineering and physics texts, this groundbreaking book—in color throughout—includes only the most essential formulas as well as many noncalculation-based exercises. Important terms are highlighted in bold and defined in a glossary. The text contains more than 400 color figures, most of which are from the original researchers.
Coverage of both historical perspectives and the latest developments
Developed from the author’s long-running course, this classroom-tested text gives readers a vivid picture of how the field has grown by presenting historical perspectives and a timeline of seminal discoveries. It also describes numerous state-of-the-art biomedical applications that benefit from "going small," including devices that record the electrical activity of brain cells, measure the diffusion of molecules in microfluidic channels, and allow for high-throughput studies of gene expression.
Optical Techniques in Regenerative Medicine illustrates how to use optical imaging techniques and instrumentation for the fabrication, assessment, and longitudinal monitoring of regenerative medicine therapies. The book covers optical coherence tomography, acousto-optic imaging, Raman spectroscopy, machine vision, bioluminescence, second harmonic generation microscopy, multi-photon microscopy, coherent anti-Stokes Raman scattering, fluorescence spectroscopy, and light scattering spectroscopy. Each chapter provides an overview of a particular technique, its advantages and limitations in terms of structural and functional information, and examples of applications in regenerative medicine.
The future evolution of regenerative medicine from academic research to viable clinical alternatives to conventional treatments is dependent on the development of non-destructive analytical techniques that can elucidate the stages of tissue development both in vitro and in vivo as well as track the fate of cells following injection. This practical book demonstrates the vital role of optical techniques in the dynamic field of regenerative medicine. It guides regenerative medicine researchers toward finding the most appropriate technique for their applications and helps biophotonics researchers see where their technologies can be applied.
Recent applications of nanotechnology in the biomedical field have developed in response to an increased demand for innovative approaches to diagnosis, exploratory procedures and therapy. The book provides the reader with a strong grounding in emerging biomedical nanofabrication technologies, covering numerous fabrication routes for specific applications are described in detail and discussing synthesis, characterization and current or potential future use.
This book will be of interest to professors, postdoctoral researchers and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians.An up-to-date and highly structured reference source for practitioners, researchers and students working in biomedical, biotechnological and engineering fieldsA valuable guide to recent scientific progress, covering major and emerging applications of nanomaterials in the biomedical fieldProposes novel opportunities and ideas for developing or improving technologies in fabrication and self-assembly
Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment examines many of these challenges, paying particular attention to how the healing of tissues surrounding an implant can impact the intended use of a device. The contributions are divided into four sections
· Part one examines wound healing from the initial insertion trauma through the inflammatory and repair process, explaining how the action of healing varies throughout different areas of the body.
· Part two considers various performance issues specific to particular implant components, including those that arise from the chemical, mechanical, thermal, and electrical impact on surrounding tissues. It discusses challenges that result from chronic tissue stimulation and heat effects that occur with on-chip and telemetric processing.
· Part three presents both in vitro and in vivo approaches to assessing wound healing response to materials. It includes the contribution of the developer of a chronic hollow fiber membrane implant who explains how an in vivo model is used to assess molecular transport in brain tissue surrounding the implant.
· The final section evaluates molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between the electrode surface and the surrounding tissue. It also presents novel approaches to nerve regeneration and repair.
This seminal work provides researchers with an up-to-date account of the progress in the field that they can build upon to bring us closer to realizing the full value of neural implants in combating otherwise intractable human health problems.
Articles explore the basic mechanical principles of bone-related study and how to conduct mechanical testing of bone specimens. More practical than theoretical, the text includes 42 chapters in three sections that cover mechanical properties of bone, general considerations of mechanical testing, basic facilities and instruments for mechanical testing; mechanical testing procedures on bone tissues; and mechanical testing procedures on the implant-bone interface. There are approximately three hundred illustrations, including line drawings, diagrams, tables, and photographs.
Mechanical Testing of Bone and the Bone-Implant Interface is the most concise, straightforward, and in-depth treatment ever to be published - long needed by the orthopedic and bone research communities.
Hard and soft tissue mechanics
Relief procedures using computer tomography, evaluation of image processing techniques, and pre-surgical activity
Dental materials relating to implants, titanium cast devices, metallurgic problems and implant surface treatments
Mechanical testing procedures for reliability evaluation of dental devices
Relevant aspects of clinical practice with reference to biomechanical problems
Orthodontic treatments in relation to the mechanical characteristics of orthodontic appliances
Numerical modeling in dental biomechanics, highlighting the relevance of this approach for the investigation of dental problems
Mechanics of materials
A unique book, Dental Biomechanics will be of interest to all bioengineers and clinicians with its presentation of a multidisciplinary approach to dental biomechanics based on mechanical, clinical, and chemical-physical knowledge.
Part I deals with the principles, mode of operation, and uses of various biomedical instruments and devices, including transducers, electrocardiograph, implantable electrical devices, biotelemetry, patient monitoring systems, hearing aids, and implantable insulin delivery systems. Parts II and III describe the basic principle of medical imaging devices and the application of computers in medicine, particularly in the fields of data management, critical care, clinical laboratory, radiology, artificial intelligence, and research. Part IV focuses on the application of biomaterials and biomechanics in orthopedic and accident investigation, while Part V considers the major functions of clinical engineering. Part VI provides the principles and application of mathematical models in physiological systems analysis.
This book is valuable as a general reference for courses in a biomedical engineering curriculum.
Organized into three parts, the handbook:
Gives readers a toolkit for performing assessments
Describes the roles of the assessment team members, among them the new profession of the psychotechnologist, who is skilled in understanding individuals and their psychosocial and technological needs and preferences
Reviews cutting-edge technologies for rehabilitation and independent living, including brain–computer interfaces and microswitches
The book synthesizes information scattered throughout the international literature, focusing on aspects that are particularly representative or innovative. It also addresses the challenges posed by the variety of health and social care systems and the different ways that individuals who need aid are defined—are they users, patients, clients, or consumers, and how does that affect the assessment?
Edited by Stefano Federici and Marcia J. Scherer, internationally renowned leaders in the field of assistive technology assessment, this cross-cultural handbook includes contributions from leading experts across five continents. Guiding readers in matching the person and the appropriate assistive technology, it offers a framework for future practice and research.Listen to Stefano Federici talk about the handbook.
While Polymers in Drug Delivery offers much new insight for the veteran specialist, this work has been compiled with the non-specialist in mind. It includes contributions from many of the world’s leading drug delivery specialists, yet avoids jargon and presents background information that initiates the next generation of scientists into the amazing work going on at the frontiers of this rapidly evolving science.
Targeting specific issues at the forefront of drug delivery today, this engaging volume—
· Outlines the issues that must be considered when selecting a polymer for fabricating a drug delivery agent or other medical devices
· Explains the more commonly used methods by which polymers may be characterized prior to use
· Profiles polymer matrices that have been used in the formulation of solid oral dosage forms, drug delivery scaffolds, and hydrogels
· Examines the issues surrounding the encapsulation of biologics within microspheres
· Explores the use of nanoparticulates, especially solid nanoparticles and nanocapsules prepared from largely-water-insoluble cyanoacrylate polymers
· Discusses polymeric micelles and investigates the potential of soluble polymer prodrugs and polymer nanomedicines
· Details the contribution made by polymers and dendrimers to the gene delivery effort, which may one day lead to effective treatments for largely incurable diseases
Noting a dramatic paradigm shift that is bridging the gap between materials science and life science, the editor’s have compiled this volume to paint an interdisciplinary portrait of drug delivery that will challenge young scientists to turn their attention and effort towards this critical branch of biomedicine. Containing state-of-the-art information for drug delivery scientists, it is also a great choice for medical and pharmaceutical students and others seeking an in-depth introduction to the field.
Written by field experts with proven track records, this authoritative textbook first provides an introduction to systems biology and its impact on biology and medicine. The book then reviews the basic principles of molecular and cell biology using a system-oriented approach, with a brief description of the high-throughput biological experiments that produce databases.
The text includes techniques to discover genes, perform nucleotide and amino acid sequence matching, and estimate static gene dynamic pathways. The book also explains how to use system-oriented models to predict the behavior of biological systems for important applications such as rational drug design.
The numerous examples and problem sets allow students to confidently explore practical systems biology applications using real examples with real biological data, making Systems Biology and Bioinformatics: A Computational Approach an ideal text for senior undergraduate and first-year graduate students.
Reflecting the enormous growth and change in biomedical engineering during the infancy of the 21st century, The Biomedical Engineering Handbook enters its third edition as a set of three carefully focused and conveniently organized books. Offering an overview of the tools of the biomedical engineering trade, Medical Devices and Systems reviews the currently available technologies and lays a foundation for the next generation of medical devices. Beginning with biomedical signal analysis, renowned experts from around the world share their experience in imaging, sensing technologies, medical instruments and devices, clinical engineering, and ethics. In addition to new and updated chapters throughout, the book also contains new sections on infrared imaging and medical informatics.
Engineers must be prepared to develop technologies that are more than incremental improvements over existing devices and systems. Medical Devices and Systems illuminates a path to achieving remarkable breakthroughs.
Authored by one of the founding fathers of the field, the book introduces fabrication and manufacturing methods of several electrically and chemically active ionic polymeric sensors, actuators, and artificial muscles, as well as a new class of electrically active polymeric nanocomposites and artificial muscles. It also describes a few apparatuses for modeling and testing various artificial muscles to show the viability of chemoactive and electroactive muscles. The authors present the theories, modeling, and numerical simulations of ionic polymeric artificial muscles’ electrodynamics and chemodynamics. In addition, they feature current industrial and medical applications of IPMNCs.
By covering the fabrication techniques of and novel developments in advanced polymeric nanocomposites, this book provides a solid foundation in the subject while stimulating further research.
Describes physical principles and mathematical procedures of two medical imaging techniques: X-ray CT and MRI Presents statistical properties of imaging data (measurements) at each stage in the imaging processes of X-ray CT and MRI Demonstrates image reconstruction as a transform from a set of random variables (imaging data) to another set of random variables (image data) Presents statistical properties of image data (pixel intensities) at three levels: a single pixel, any two pixels, and a group of pixels (a region) Provides two stochastic models for X-ray CT and MR image in terms of their statistics and two model-based statistical image analysis methods Evaluates statistical image analysis methods in terms of their detection, estimation, and classification performances Indicates that X-ray CT, MRI, PET and SPECT belong to a category of imaging: the non-diffraction computed tomography
Rather than offering detailed descriptions of statistics of basic imaging protocols of X-ray CT and MRI, this book provides a method to conduct similar statistical investigations into more complicated imaging protocols.
Keeping this duality in mind throughout, BioMEMS: Science and Engineering Perspectives supports and expedites the multidisciplinary learning involved in the development of biomicrosystems. Divided into nine chapters, it starts with a balanced introduction of biological, engineering, application, and commercialization aspects of the field. With a focus on molecules of biological interest, the book explores the building blocks of cells and viruses, as well as molecules that form the self-assembled monolayers (SAMs), linkers, and hydrogels used for making different surfaces biocompatible through functionalization.
The book also discusses:
Different materials and platforms used to develop biomicrosystems
Various biological entities and pathogens (in ascending order of complexity)
The multidisciplinary aspects of engineering bioactive surfaces
Engineering perspectives, including methods of manufacturing bioactive surfaces and devices
Microfluidics modeling and experimentation
Device level implementation of BioMEMS concepts for different applications.
Because BioMEMS is an application-driven field, the book also highlights the concepts of lab-on-a-chip (LOC) and micro total analysis system (μTAS), along with their pertinence to the emerging point-of-care (POC) and point-of-need (PON) applications.