This atlas is an up-to-date reference work on imaging in carotid artery stenosis written by internationally renewed experts. The authors take the reader step by step through illustrated descriptions of state-of-the-art imaging techniques that they have helped to develop, and demonstrate that these techniques are crucial in the management of patients. This book covers all facets of imaging in carotid artery stenosis and gives an outlook to future aspects. The "take-home-messages" at the end of each chapter are a quick help in daily practice.
Thousands of people have had near-death experiences, but scientists have argued that they are impossible. Dr. Eben Alexander was one of those scientists. A highly trained neurosurgeon, Alexander knew that NDEs feel real, but are simply fantasies produced by brains under extreme stress.
Then, Dr. Alexander’s own brain was attacked by a rare illness. The part of the brain that controls thought and emotion—and in essence makes us human—shut down completely. For seven days he lay in a coma. Then, as his doctors considered stopping treatment, Alexander’s eyes popped open. He had come back.
Alexander’s recovery is a medical miracle. But the real miracle of his story lies elsewhere. While his body lay in coma, Alexander journeyed beyond this world and encountered an angelic being who guided him into the deepest realms of super-physical existence. There he met, and spoke with, the Divine source of the universe itself.
Alexander’s story is not a fantasy. Before he underwent his journey, he could not reconcile his knowledge of neuroscience with any belief in heaven, God, or the soul. Today Alexander is a doctor who believes that true health can be achieved only when we realize that God and the soul are real and that death is not the end of personal existence but only a transition.
This story would be remarkable no matter who it happened to. That it happened to Dr. Alexander makes it revolutionary. No scientist or person of faith will be able to ignore it. Reading it will change your life.
In this Pulitzer Prize finalist and national bestseller, one of the world's leading cognitive scientists tackles the workings of the human mind. What makes us rational—and why are we so often irrational? How do we see in three dimensions? What makes us happy, afraid, angry, disgusted, or sexually aroused? Why do we fall in love? And how do we grapple with the imponderables of morality, religion, and consciousness? How the Mind Works synthesizes the most satisfying explanations of our mental life from cognitive science, evolutionary biology, and other fields to explain what the mind is, how it evolved, and how it allows us to see, think, feel, laugh, interact, enjoy the arts, and contemplate the mysteries of life.
This edition of Pinker's bold and buoyant classic is updated with a new foreword by the author.
How many times have you seen a murder on the news or on a TV show like CSI: Crime Scene Investigation, and said to yourself, “How could someone do something like that?”
Today, neuroscientists are imaging, mapping, testing and dissecting the source of the worst behavior imaginable in the brains of the people who lack a conscience: psychopaths. Neuroscientist Dean Haycock examines the behavior of real life psychopaths and discusses how their actions can be explained in scientific terms, from research that literally looks inside their brains to understanding how psychopaths, without empathy but very goal-oriented, think and act the way they do. Some don’t commit crimes at all, but rather make use of their skills in the boardroom.
But what does this mean for lawyers, judges, psychiatrists, victims, and readers—for anyone who has ever wondered how some people can be so bad. Could your nine-year-old be a psychopath? What about your co-worker? The ability to recognize psychopaths using the scientific method has vast implications for society, and yet is still loaded with consequences.
*An NBC News Notable Science Book of 2015*
*Named one of Publishers Weekly's Best Books of 2015*
*A Book of the Month for Brain HQ/Posit Science*
*Selected by Forbes as a Must Read Brain Book of 2015*
*On Life Changes Network’s list of the Top 10 Books That Could Change Your Life of 2015*
In the tradition of Oliver Sacks, a tour of the latest neuroscience of schizophrenia, autism, Alzheimer’s disease, ecstatic epilepsy, Cotard’s syndrome, out-of-body experiences, and other disorders—revealing the awesome power of the human sense of self from a master of science journalism.
Anil Ananthaswamy’s extensive in-depth interviews venture into the lives of individuals who offer perspectives that will change how you think about who you are. These individuals all lost some part of what we think of as our self, but they then offer remarkable, sometimes heart-wrenching insights into what remains. One man cut off his own leg. Another became one with the universe.
We are learning about the self at a level of detail that Descartes (“I think therefore I am”) could never have imagined. Recent research into Alzheimer’s illuminates how memory creates your narrative self by using the same part of your brain for your past as for your future. But wait, those afflicted with Cotard’s syndrome think they are already dead; in a way, they believe that “I think therefore I am not.” Who—or what—can say that? Neuroscience has identified specific regions of the brain that, when they misfire, can cause the self to move back and forth between the body and a doppelgänger, or to leave the body entirely. So where in the brain, or mind, or body, is the self actually located? As Ananthaswamy elegantly reports, neuroscientists themselves now see that the elusive sense of self is both everywhere and nowhere in the human brain.
From the Hardcover edition.
Psychiatry has come a long way since the days of chaining "lunatics" in cold cells. But, as Jeffrey Lieberman, MD, reveals in his eye-opening book, the path to legitimacy for "the black sheep of medicine" has been anything but smooth.
Dr. Lieberman traces the field from its birth as a mystic pseudo-science to its late blooming maturity--beginning after World War II--as a science-driven profession that saves lives. With fascinating case studies and portraits of the field's luminaries--from Sigmund Freud to Eric Kandel--SHRINKS is a gripping read, and an urgent call-to-arms to dispel the stigma of mental illnesses by treating them as diseases rather than unfortunate states of mind.
NAMED ONE OF THE BEST BOOKS OF THE YEAR BY THE WASHINGTON POST
Imagine spending the first forty years of your life in darkness, blind to the emotions and social signals of other people. Then imagine that someone suddenly switches the lights on.
It has long been assumed that people living with autism are born with the diminished ability to read the emotions of others, even as they feel emotion deeply. But what if we’ve been wrong all this time? What if that “missing” emotional insight was there all along, locked away and inaccessible in the mind?
In 2007 John Elder Robison wrote the international bestseller Look Me in the Eye, a memoir about growing up with Asperger’s syndrome. Amid the blaze of publicity that followed, he received a unique invitation: Would John like to take part in a study led by one of the world’s foremost neuroscientists, who would use an experimental new brain therapy known as TMS, or transcranial magnetic stimulation, in an effort to understand and then address the issues at the heart of autism? Switched On is the extraordinary story of what happened next.
Having spent forty years as a social outcast, misreading others’ emotions or missing them completely, John is suddenly able to sense a powerful range of feelings in other people. However, this newfound insight brings unforeseen problems and serious questions. As the emotional ground shifts beneath his feet, John struggles with the very real possibility that choosing to diminish his disability might also mean sacrificing his unique gifts and even some of his closest relationships. Switched On is a real-life Flowers for Algernon, a fascinating and intimate window into what it means to be neurologically different, and what happens when the world as you know it is upended overnight.
Praise for Switched On
“An eye-opening book with a radical message . . . The transformations [Robison] undergoes throughout the book are astonishing—as foreign and overwhelming as if he woke up one morning with the visual range of a bee or the auditory prowess of a bat.”—The New York Times
“Astonishing, brave . . . reads like a medical thriller and keeps you wondering what will happen next . . . [Robison] takes readers for a ride through the thorny thickets of neuroscience and leaves us wanting more.”—The Washington Post
“Fascinating for its insights into Asperger’s and research, this engrossing record will make readers reexamine their preconceptions about this syndrome and the future of brain manipulation.”—Booklist
“Like books by Andrew Solomon and Oliver Sacks, Switched On offers an opportunity to consider mental processes through a combination of powerful narrative and informative medical context.”—BookPage
“A mind-blowing book that will force you to ask deep questions about what is important in life. Would normalizing the brains of those who think differently reduce their motivation for great achievement?”—Temple Grandin, author of The Autistic Brain
“At the heart of Switched On are fundamental questions of who we are, of where our identity resides, of difference and disability and free will, which are brought into sharp focus by Robison’s lived experience.”—Graeme Simsion, author of The Rosie Effect
We all have a rage circuit we can’t fully control once it is engaged as R. Douglas Fields, PhD, reveals in this essential book for our time. The daily headlines are filled with examples of otherwise rational people with no history of violence or mental illness suddenly snapping in a domestic dispute, an altercation with police, or road rage attack. We all wish to believe that we are in control of our actions, but the fact is, in certain circumstances we are not. The sad truth is that the right trigger in the right circumstance can unleash a fit of rage in almost anyone.
But there is a twist: Essentially the same pathway in the brain that can result in a violent outburst can also enable us to act heroically and altruistically before our conscious brain knows what we are doing. Think of the stranger who dives into a frigid winter lake to save a drowning child.
Dr. Fields is an internationally recognized neurobiologist and authority on the brain and the cellular mechanisms of memory. He has spent years trying to understand the biological basis of rage and anomalous violence, and he has concluded that our culture’s understanding of the problem is based on an erroneous assumption: that rage attacks are the product of morally or mentally defective individuals, rather than a capacity that we all possess.
Fields shows that violent behavior is the result of the clash between our evolutionary hardwiring and triggers in our contemporary world. Our personal space is more crowded than ever, we get less sleep, and we just aren't as fit as our ancestors. We need to understand how the hardwiring works and how to recognize the nine triggers. With a totally new perspective, engaging narrative, and practical advice, Why We Snap uncovers the biological roots of the rage response and how we can protect ourselves—and others.
From the Hardcover edition.
Do you:Want to write, but find it impossible to get started? Keep your schedules so full that you don’t have any time to write? Wait until the last minute to write, even though you know you could do a better job if you gave yourself more time? Suddenly remember ten other things that you need to do whenever you sit down to write? Sabotage your own best efforts with lost files, missed deadlines, or excessive self-criticism?
The good news is that you’re not lazy, undisciplined, or lacking in willpower, talent or ambition. You just need to learn what’s going on inside your brain, and harness the power of brain science to beat resistance and develop a productive writing habit.
In Around the Writer’s Block, Rosanne Bane-- a creativity coach and writing teacher for more than 20 years-- uses the most recent breakthroughs in brain science to help us understand, in simple, clear language, where writing resistance comes from: a fight-or-flight response hard-wired into our brain, which can make us desperate to flee the sources of our anxieties by any means possible.
Bane’s three-part plan, which has improved the productivity of thousands of writers, helps you develop new reliable writing habits, rewire the brain’s responses to the anxiety of writing, and turn writing from a source of stress and anxiety into one of joy and personal growth.
The New York Times–bestselling author of The Brain That Changes Itself presents astounding advances in the treatment of brain injury and illness. Now in an updated and expanded paperback edition.
Winner of the 2015 Gold Nautilus Award in Science & Cosmology
In his groundbreaking work The Brain That Changes Itself, Norman Doidge introduced readers to neuroplasticity—the brain’s ability to change its own structure and function in response to activity and mental experience. Now his revolutionary new book shows how the amazing process of neuroplastic healing really works. The Brain’s Way of Healing describes natural, noninvasive avenues into the brain provided by the energy around us—in light, sound, vibration, and movement—that can awaken the brain’s own healing capacities without producing unpleasant side effects. Doidge explores cases where patients alleviated chronic pain; recovered from debilitating strokes, brain injuries, and learning disorders; overcame attention deficit and learning disorders; and found relief from symptoms of autism, multiple sclerosis, Parkinson’s disease, and cerebral palsy. And we learn how to vastly reduce the risk of dementia, with simple approaches anyone can use.
For centuries it was believed that the brain’s complexity prevented recovery from damage or disease. The Brain’s Way of Healing shows that this very sophistication is the source of a unique kind of healing. As he did so lucidly in The Brain That Changes Itself, Doidge uses stories to present cutting-edge science with practical real-world applications, and principles that everyone can apply to improve their brain’s performance and health.
It is now evident that the "illegal biologicals" he referred to included the pathogenic agents which have led to the AIDS epidemic and other world health crisis.
In The Extremely Unfortunate Skull Valley Incident the authors trace history of the secret war against and the terrible experiments performed upon their own citizens as well as the Third World populations. But Skull Valley does more than that. In their research the father-son team discovered the links between AIDS and many other diseases now increasing dramatically worldwide. Chief among these is myalgic encephalomyelitis/fibromyalgia dismissively labelled " chronic fatigue syndrome" by the government researchers.
In addition to AIDS and ME/FM the Scotts also demonstrate the etiological links to other neurosystemic degenerative diseases such as Alzheimer's, multiple sclerosis, Parkinson's, diabetes, schizophrenia, Crohn's-colitis, etc. All are said to be "of no known cause and having no known cure". Researchers Donald and William Scott have discovered that there is a "known cause" and there may well be a cure.
The cause is a little known organism called the "mycoplasma" which has the capacity to access genetically pre-disposed cells and to destroy them by up-taking pre-formed sterols. This process is the "degeneration" which characterizes all of the diseases under study. When the cells of the endocrine system are destroyed by a sufficient concentration of mycoplasmas, the balance of the physiological balance is altered and the immune system loses its ability to defend the infected victim, and co-factors such as the human immune-deficiency virus (HIV), and those with cause pneumonia, are free to have their way, leading to full-blown AIDS.
Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before.
In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extension—even age reversal—has moved from science fiction to real possibility.
Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging.
Twenty years ago, there was still considerable debate of the nature of human aging, with a variety of competing theories in play. But scientific consensus is forming around the telomere theory of aging. The essence of this theory is that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres (the tips of the chromosomes) shorten. With every shortening of the telomeres, the cell’s ability to repair its molecules decreases. It ages. Human aging is the result of the aging of the body’s trillions of cells.
But some of our cells don’t age. Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. Telomerase re-lengthens the telomeres, keeping these cells young.
The Telomerase Revolution describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to dramatically extend life spans and even reverse human aging. Telomerase-based treatments are already available, and have shown early promise, but much more potent treatments will become available over the next decade.
The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.
Aldous Huxley called humankind's basic trend toward spiritual growth the "perennial philosophy." In the view of James Austin, the trend implies a "perennial psychophysiology"—because awakening, or enlightenment, occurs only when the human brain undergoes substantial changes. What are the peak experiences of enlightenment? How could these states profoundly enhance, and yet simplify, the workings of the brain? Zen and the Brain presents the latest evidence. In this book Zen Buddhism becomes the opening wedge for an extraordinarily wide-ranging exploration of consciousness. In order to understand which brain mechanisms produce Zen states, one needs some understanding of the anatomy, physiology, and chemistry of the brain. Austin, both a neurologist and a Zen practitioner, interweaves the most recent brain research with the personal narrative of his Zen experiences. The science is both inclusive and rigorous; the Zen sections are clear and evocative. Along the way, Austin examines such topics as similar states in other disciplines and religions, sleep and dreams, mental illness, consciousness-altering drugs, and the social consequences of the advanced stage of ongoing enlightenment.
Barrett begins with an overview of human cognitive adaptations and how these color our views of other species, brains, and minds. Considering when it is worth having a big brain--or indeed having a brain at all--she investigates exactly what brains are good at. Showing that the brain's evolutionary function guides action in the world, she looks at how physical structure contributes to cognitive processes, and she demonstrates how these processes employ materials and resources in specific environments.
Arguing that thinking and behavior constitute a property of the whole organism, not just the brain, Beyond the Brain illustrates how the body, brain, and cognition are tied to the wider world.
Luca Turin can distinguish the components of just about any smell, from the world’s most refined perfumes to the air in a subway car on the Paris metro. A distinguished scientist, he once worked in an unrelated field, though he made a hobby of collecting fragrances. But when, as a lark, he published a collection of his reviews of the world’s perfumes, the book hit the small, insular business of perfume makers like a thunderclap. Who is this man Luca Turin, they demanded, and how does he know so much? The closed community of scent creation opened up to Luca Turin, and he discovered a fact that astonished him: no one in this world knew how smell worked. Billions and billions of dollars were spent creating scents in a manner amounting to glorified trial and error.
The solution to the mystery of every other human sense has led to the Nobel Prize, if not vast riches. Why, Luca Turin thought, should smell be any different? So he gave his life to this great puzzle. And in the end, incredibly, it would seem that he solved it. But when enormously powerful interests are threatened and great reputations are at stake, Luca Turin learned, nothing is quite what it seems.
Acclaimed writer Chandler Burr has spent four years chronicling Luca Turin’s quest to unravel the mystery of how our sense of smell works. What has emerged is an enthralling, magical book that changes the way we think about that area between our mouth and our eyes, and its profound, secret hold on our lives.
From the Hardcover edition.
*A new book in the Basic Concepts series
*Explains the fundamental principles of neuroscience and helps students organize and condense the material they need to study
*Level of the material progressively builds from simple to complex, enabling mastery of concepts
*Content is presented in simple, jargon-free language
*Critical need-to-know information is highlights in boxes
*Numerous tables and charts help compare and contrast key information
Your Brain: The Missing Manual is a practical look at how to get the most out of your brain -- not just how the brain works, but how you can use it more effectively. What makes this book different than the average self-help guide is that it's grounded in current neuroscience. You get a quick tour of several aspects of the brain, complete with useful advice about:
Brain Food: The right fuel for the brain and how the brain commands hunger (including an explanation of the different chemicals that control appetite and cravings)Sleep: The sleep cycle and circadian rhythm, and how to get a good night's sleep (or do the best you can without it)Memory: Techniques for improving your recallReason: Learning to defeat common sense; logical fallacies (including tactics for winning arguments); and good reasons for bad prejudicesCreativity and Problem-Solving: Brainstorming tips and thinking not outside the box, but about the box -- in other words, find the assumptions that limit your ideas so you can break through themUnderstanding Other People's Brains: The battle of the sexes and babies developing brains
Learn about the built-in circuitry that makes office politics seem like a life-or-death struggle, causes you to toss important facts out of your memory if they're not emotionally charged, and encourages you to eat huge amounts of high-calorie snacks. With Your Brain: The Missing Manual you'll discover that, sometimes, you can learn to compensate for your brain or work around its limitations -- or at least to accept its eccentricities.
Exploring your brain is the greatest adventure and biggest mystery you'll ever face. This guide has exactly the advice you need.
The book presents diffusion imaging in the context of well-established, classical experimental techniques, so that readers will be able to assess the scope and limitations of the new imaging technology with respect to techniques available previously.
All chapters are written by leading international experts and cover methodology, validation of the imaging technology, application of diffusion imaging to the study of variation and development of normal brain anatomy, and disruption to the white matter in neurological disease or psychiatric disorder.
• Discusses all aspects of a diffusion MRI study from acquisition, through analysis, to interpretation, providing an essential reference text for scientists designing or interpreting diffusion MR experiments
• Practical advice on running an experiment
• Full color throughout
The book is divided into three sections covering optical principles in diffraction and image formation, basic modes of light microscopy, and components of modern electronic imaging systems and image processing operations. Each chapter introduces relevant theory, followed by descriptions of instrument alignment and image interpretation. This revision includes new chapters on live cell imaging, measurement of protein dynamics, deconvolution microscopy, and interference microscopy.
PowerPoint slides of the figures as well as other supplementary materials for instructors are available at a companion website:
The brain and the nervous system are our most cultural organs. Our nervous system is especially immature at birth, our brain disproportionately small in relation to its adult size and open to cultural sculpting at multiple levels. Recognizing this, the new field of neuroanthropology places the brain at the center of discussions about human nature and culture. Anthropology offers brain science more robust accounts of enculturation to explain observable difference in brain function; neuroscience offers anthropology evidence of neuroplasticity's role in social and cultural dynamics. This book provides a foundational text for neuroanthropology, offering basic concepts and case studies at the intersection of brain and culture.
After an overview of the field and background information on recent research in biology, a series of case studies demonstrate neuroanthropology in practice. Contributors first focus on capabilities and skills—including memory in medical practice, skill acquisition in martial arts, and the role of humor in coping with breast cancer treatment and recovery—then report on problems and pathologies that range from post-traumatic stress disorder among veterans to smoking as a part of college social life.
Mauro C. Balieiro, Kathryn Bouskill, Rachel S. Brezis, Benjamin Campbell, Greg Downey, José Ernesto dos Santos, William W. Dressler, Erin P. Finley, Agustín Fuentes, M. Cameron Hay, Daniel H. Lende, Katherine C. MacKinnon, Katja Pettinen, Peter G. Stromberg
Neurophysiology in Neurosurgery is a valuable educational tool that describes the theoretical and practical aspects of intraoperative monitoring through example. The authors provide in-depth descriptions of the most advanced techniques in intraoperative neurophysiological monitoring and guidelines for the management of neuroanesthesia during MEP monitoring.
This volume presents neuroprotection and novel therapeutic strategies developed in the last 5 years by 12 world leaders in the field. The term neuroprotection means rescuing neuronal and non-neuronal cells together. The cerebral endothelium that constitutes the anatomical and physiological site of the blood-brain barrier (BBB) is one of the most important non-neural cells in the CNS. Any distortion of the BBB leads to brain diseases and restoration of the barrier results in neuroprotection. Thus, the BBB appears to be the "gateway" for neurological diseases and neurorepair. However, to treat brain tumors or infarcts, new therapeutic strategies are needed to enhance brain drug delivery using nanotechnology. In addition, apart from conventional drugs, restoration of BBB function could also be achieved by means of antibodies directed against specific proteins, neurotransmitters or exogenous supplement of neurotrophic factors. Since co-morbidity factors e.g., hypertension, diabetes, and exposure of nanoparticles could complicate the pathogenesis of neurological disorders either an enhanced dose of the drug or nanodelivery of a combination of several drugs is needed to achieve neuroprotection.
This volume of International Review of Neurobiology is the first to discuss novel therapeutic strategies in situations of neurological disorders in combination with different co-morbidity factors.Reviews written by experts in such a way that provides basic knowledge for beginners and advanced information for researchers and expertsNew aspects of Neurodegenerative diseases such as; Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis are presented with the latest therapeutic measuresExacerbation of brain pathology in hypertension or diabetes is discussed for the first time
The book begins with a general coverage of the characteristics of swine and the swine industry with emphasis on the gastrointestinal tract. It then describes the various classes of nutrients and how these nutrients are metabolized by swine and the factors affecting their utilization. The next section covers the practical aspects of swine nutrition from birth through gestation and lactation in sows and to the feeding of adult boars. The nutritional aspects of the various feedstuffs commonly fed to swine are covered in the following section. The final chapters of the book are devoted to coverage of various techniques used in swine nutrition research.
New to This Edition
*Incorporates significant scientific advances and many new topics.
*Greatly expanded coverage of clinical issues and applications.
*Chapters on neural systems, delay of gratification, decision making, and health.
*Chapters on adolescence, social baseline theory, and desire regulation, plus more.
*Supplemental e-book featuring selected chapters from the prior edition.
This volume provides formulas and procedures for determination of sample size required not only for testing equality, but also for testing non-inferiority/superiority, and equivalence (similarity) based on both untransformed (raw) data and log-transformed data under a parallel-group design or a crossover design with equal or unequal ratio of treatment allocations. It contains a comprehensive and unified presentation of statistical procedures for sample size calculation that are commonly employed at various phases of clinical development. Each chapter includes, whenever possible, real examples of clinical studies from therapeutic areas such as cardiovascular, central nervous system, anti-infective, oncology, and women's health to demonstrate the clinical and statistical concepts, interpretations, and their relationships and interactions.
The book highlights statistical procedures for sample size calculation and justification that are commonly employed in clinical research and development. It provides clear, illustrated explanations of how the derived formulas and/or statistical procedures can be used.
Rapid advances in DNA sequencing technology have led to a major change in the way that prokaryotes are classified. Sequence analysis of highly conserved regions of the bacterial genome, such as the small subunit rRNA gene, now provide us with a universal method of estimating the evolutionary relationships among all organisms. Such gene-based phylogenetic classifications have led to many new discoveries about prokaryotes that were not reflected in the classification used in the first edition of the Manual. We now know that the prokaryotes fall into two broad domains: the Archaea and the Bacteria. Whereas the Archaea were once thought of as the more primitive of the prokaryotic lineages, we now realize that they are more closely related to the eukaryotes than to the Bacteria by this measure. We have come to realize that many taxa based on shared phenotypic features may be quite distinct from one another based on phylogenetic evidence. The Chromatium, a genus of anoxygenic photosynthetic bacteria are more closely related to E. coli than to some other lineages of anoxygenic photosynthetic bacteria; Mycoplasma and other cell-wall deficient species are members of the Gram-positive clade; the medically important Chlamydia are aligned with the Planctomyces; and the Clostridium, which form a phenotypically coherent group, fall into more than a dozen phylogenetically disparate groups of Gram-positive bacteria. We have also come to realize that prokaryotes represent one of the major sources of biodiversity in nature and play a major role in the functioning of all ecosystems.
In addition to such fundamental revelations, the widespread application of new methods of classifying prokaryotes has led to an explosive growth in the number of validly published species and higher taxa. Since completion of the first edition of the Manual, the number of published species has more than tripled and has been accompanied by numerous taxonomic realignments that take into consideration newly published findings.
Phylogenetic classification is now broadly accepted as the preferred method of representing taxonomic relationships among prokaryotes and eukaryotes alike. While the evolutionary history of the prokaryotes is far from complete, there is already sufficient data to provide a reasonable view of the major lines of descent of the cultivable species. Although the second edition of the Manual retains it’s unique and highly structured style of presentation of information along genus and species lines, the arrangement of content is along the phylogenetic lines of the small subunit rRNA gene, so that the reader is presented with the information in a more natural, biological perspective. The second edition of the Manual also contains more in-depth ecological information about individual taxa and many new introductory essays.
In the preface to the first edition of Bergey’s Manual of Determinative Bacteriology, published in 1923, one of the stated goals of that work was to "stimulate efforts to perfect the classification of bacteria..." The editors of the first edition regarded the Manual as "a progress report leading to a more satisfactory classification in the future" rather than a definitive classification. Bergey’s Manual Trust continues in this tradition and recognizes that, for the Manual to remain scientifically meaningful and useful to the scientific community, it is time for the new edition.
Overview of the second edition of the Manual
As before, the Manual is subdivided into multiple volumes and each genus occurs as a separate chapter with introductory text provided at higher taxonomic levels. The second edition differs from the first in that clinically relevant species are not grouped together into two volumes. Rather, these taxa appear in their proper phylogenetic place. The text is arranged to follow the lineages defined by the large-scale phylogenetic trees maintained by the Ribosomal Database Project and the ARB Project to which a formalized, hierarchical taxonomy and nomenclature have been applied. As volume 2 goes to press, the taxonomy encompasses 6466 species that are assigned to 26 phyla, 41 classes, 88 orders, 240 families and 1194 genera. Each volume contains a collection of introductory essays on the history and use of the Manual; a detailed discussion of the prokaryotic domains; overviews of the classification, identification, and naming of prokaryotes; prokaryotic ecology and phylogeny; the role of culture collections in microbiology; and intellectual property of prokaryotes. Each volume also includes taxon specific essays and a detailed road map that presents the reader with a broad view of how the entire edition will be arranged, a mapping of phylogenetic groups to the phenotypic groups used in the first edition (Volume 1), or an update of newly published taxa and combinations appearing in print since the preceding volume (Volumes 2-5). The details of each volume in print (Volume 1), in press (Volume 2) or in preparation (Volumes 3-5) follow.
Volume 1 "The Archaea and the Deeply Branching and Phototrophic Bacteria" (2001) David R. Boone and Richard W. Castenholz (Volume Editors), George M. Garrity (Editor-in-Chief) with contributions from 105 colleagues. 742 pages with 320 figures and 95 tables. The volume provides descriptions of 413 species in 165 genera that are assigned to the phyla Crenarchaeota, Euryarchaeota, Aquificae, Thermatogae, Thermodesulfobacteria, "Deinococcus-Thermus", Chrysiogenetes, Chloroflexi, Thermomicrobia, Nitrospira, Deferribacteres, Cyanobacteria, and Chlorobi. In addition, the volume contains an introductory chapter to nonoxygenic, phototropic species of Bacteria belonging to the Proteobacteria and Firmicutes, which will be repeated in more detail in subsequent volumes.
Volume 2 "The Proteobacteria." (2004) Don J. Brenner, Noel R. Krieg, James T. Staley (Volume Editors), and George M. Garrity (Editor-in-Chief) with contributions from 339 colleagues. The volume provides descriptions of more than 2000 species in 538 genera that are assigned to the phylum Proteobacteria. This volume is subdivided into three parts. Part A, The Introductory Essays (332 pgs, 76 figures, 37 tables); Part B, The Gammaproteobacteria (1203 pages, 222 figures, and 300 tables); and Part C The Alpha-, Beta-, Delta-, and Epsilonproteobacteria (1256 pages, 512 figures, and 371 tables).
Volume 3 "The Firmicutes". (2005 anticipated). Paul De Vos, Dorothy Jones, Fred A. Rainey, Karl-Heinz Schleifer, Joseph Tully, (Volume Editors) and George M. Garrity (Editor-in-Chief), with contributions from 120 colleagues. This volume will provide descriptions of more than 1346 species in 235 genera belonging to the phylum Firmicutes. Anticipated length 2100 pages.
Volume 4 "The Actinobacteria". (2006 anticipated) 1141 species in 106 genera. Estimated page length: 878 with 192 tables and 321 figures. Michael Goodfellow, Peter Kaempfer, Peter H.A. Sneath, Stanley T. Williams (Volume Editors) and George M. Garrity (Editor-in-Chief) with contributions from 60 colleagues. This volume will provide descriptions of over 1534 species in 174 genera belonging to the phylum Firmicutes. Anticipated length 2454 pages.
Volume 5 "The Planctomycetes, Chlamydiae, Spirochetes, Fibrobacters, Bacteroidetes, Fusobacteria, Acidobacteria, Verrucomicrobia, Dictyoglomi, and Gemmatomonadetes " more than 405 species assigned to 114 genera in 10 phyla. Anticipated length: 648 pages Editors and authors under discussion.
With research gleaned from the National Institutes of Health, T.S. Wiley and Bent Formby deliver staggering findings: Americans really are sick from being tired. Diabetes, heart disease, cancer, and depression are rising in our population. We’re literally dying for a good night’s sleep.
Our lifestyle wasn’t always this way. It began with the invention of the lightbulb.
When we don’t get enough sleep in sync with seasonal light exposure, we fundamentally alter a balance of nature that has been programmed into our physiology since day one. This delicate biological rhythm rules the hormones and neurotransmitters that determine appetite, fertility, and mental and physical health. When we rely on artificial light to extend our day until 11 p.m., midnight, and beyond, we fool our bodies into living in a perpetual state of summer. Anticipating the scarce food supply and forced inactivity of winter, our bodies begin storing fat and slowing metabolism to sustain us through the months of hibernation and hunger that never arrive. Our own survival instinct, honed over millennia, is now killing us.
Wiley and Formby also reveal:
-That studies from our own government research prove the role of sleeplessness in diabetes, heart disease, cancer, infertility, mental illness, and premature aging
-Why the carbohydrate-rich diets recommended by many health professionals are not only ridiculously ineffective but deadly
-Why the lifesaving information that can turn things around is one of the best-kept secrets of our day.
Lights Out is one wake-up call none of us can afford to miss.
In the second part of the book, McGilchrist takes the reader on a journey through the history of Western culture, illustrating the tension between these two worlds as revealed in the thought and belief of thinkers and artists, from Aeschylus to Magritte. He argues that, despite its inferior grasp of reality, the left hemisphere is increasingly taking precedence in the modern world, with potentially disastrous consequences. This is truly a tour de force that should excite interest in a wide readership.
Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants.
This volume provides essential information for experienced development professionals but was also written to be useful for scientists just beginning work in the field and for others who need an understanding of long acting injections and implants. This book will also be ideal as a graduate textbook.
The recent International Conference on Harmonisation (ICH) revisions of regulatory requirements for quality, nonclinical, and clinical pharmaceutical product registration are the focus of this timely update.
This cutting-edge resource includes the major headings in the modular structure of the Common Technical Document (CTD), which is now the agreed format for product information submission. The format, specification, and technical requirements of the e-CTD, the electronic version of CTD, are also thoroughly discussed.
The book is organized into six highly practical segments:Part I: CTD, eCTD, Module 1, and Environmental Risk Assessment Part II: CTD Summaries Part III: Quality Topics Part IV: Nonclinical Topics Part V: Clinical Topics Part VI: Other Topics (including drug-device combination products)
This text is a must-have for those in the pharmaceutical industry determining regulatory requirements for the major world markets in Europe, the US, Canada, and Japan.
A comprehensive reference, the book includes definitive information on every aspect of the anatomy, pathophysiology, and differential diagnosis of infectious diseases affecting reptiles. Beginning with a thorough review of the biology, anatomy, and histology of reptiles, the introductory chapters cover all major systems and provide the most complete single source for color images of reptile histology. It addresses the mechanism of reptile immunology and the response to pathogens, and explains how immunological response is key to differential diagnosis. Given the difficulty in isolating certain pathogens for identification, the book provides an overview of electron microscopy, complete with electron micrographs of reptile pathogens, and introduces the necessity of molecular methods for diagnosis. The text outlines serodiagnostics and the development and use of immunological reagents specifically designed for reptiles in tests such as indirect enzyme linked immunosorbent assays (ELISA). Finally, the book devotes several chapters to the viral, bacterial, fungal, and parasitic diseases known to reptiles and methods for isolating these pathogens.
With up-to-the-minute data, a never-before-seen collection of images, and a stellar panel of contributors, Infectious Diseases and Pathology of Reptiles is the definitive resource forveterinarians, biologists, and researchers involved in the study of pathogens infecting reptiles.
Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.
Human Motor Control, 2e cuts across all movement related disciplines: physical education, dance, physical therapy, robotics, etc. This second edition incorporates advances to the field, and integrates throughout the book how research harkens back to four critical questions: how do we select our actions of the many actions possible? How are these behaviors sequenced for appropriate order and timing between them? How does perception integrate with motor control? And how are perceptual–motor skills acquired?
As before, the book retains its signature organization around activity systems. These activity systems include walking, looking, reaching, drawing and writing, keyboarding, speaking and singing, and smiling. Chapters here exemplify rather than encompass all the behaviors related to them. Hence smiling discusses physical and neural control of the face used in other expressions besides smiling, as well as the origins of emotional expression, and the importance of emotion expression in social interaction. These chapters on activity systems are preceded by chapters on basics, with an introduction and information on the physiological and psychological foundations of movement. The last section discusses integration of movements, individual differences, theories of motor control, and the contributions of both genetics and technology to motor control.
Special features of the second edition:
Organization by major activity systems
New: brain imaging, social action, embodied cognition, advances in genetics and technology
Detailed treatment of motor neuroscience
Further Readings section added to each chapter
* Retains unique organization of first edition: Part 1 on Preliminaries, Part 2 on Activity Systems, Part 3 on Principles and Prospects
* Emphasizes exciting advances in the field and promising new directions
* Well-illustrated with entertaining figures
Includes practical examples from recent trials
Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple comparison research with an emphasis on pharmaceutical applications. In each chapter, the expert contributors describe important multiplicity problems encountered in pre-clinical and clinical trial settings.
The book begins with a broad introduction from a regulatory perspective to different types of multiplicity problems that commonly arise in confirmatory controlled clinical trials, before giving an overview of the concepts, principles, and procedures of multiple testing. It then presents statistical methods for analyzing clinical dose response studies that compare several dose levels with a control as well as statistical methods for analyzing multiple endpoints in clinical trials. After covering gatekeeping procedures for testing hierarchically ordered hypotheses, the book discusses statistical approaches for the design and analysis of adaptive designs and related confirmatory hypothesis testing problems. The final chapter focuses on the design of pharmacogenomic studies based on established statistical principles. It also describes the analysis of data collected in these studies, taking into account the numerous multiplicity issues that occur.
This volume explains how to solve critical issues in multiple testing encountered in pre-clinical and clinical trial applications. It presents the necessary statistical methodology, along with examples and software code to show how to use the methods in practice.