This new book is a definitive resource on the current aspects and issues around haemophilia. Complications of haemophilia care are well covered in chapters on inhibitors, and musculoskeletal problems, as are all the latest developments in the field of haemophilia.
With the dawn of science, blood came to be seen as a component of human anatomy, capable of being isolated, studied, used. Starr describes the first documented transfusion: In the seventeenth century, one of Louis XIV's court physicians transfers the blood of a calf into a madman to "cure" him. At the turn of the twentieth century a young researcher in Vienna identifies the basic blood groups, taking the first step toward successful transfusion. Then a New York doctor finds a way to stop blood from clotting, thereby making all transfusion possible.
In the 1930s, a Russian physician, in grisly improvisation, successfully uses cadaver blood to help living patients--and realizes that blood can be stored. The first blood bank is soon operating in Chicago.
During World War II, researchers, driven by battlefield needs, break down blood into usable components that are more easily stored and transported. This "fractionation" process--accomplished by a Harvard team--produces a host of pharmaceuticals, setting the stage for the global marketplace to come. Plasma, precisely because it can be made into long-lasting drugs, is shipped and traded for profit; today it is a $5 billion business.
The author recounts the tragic spread of AIDS through the distribution of contaminated blood products, and describes why and how related scandals have erupted around the world. Finally, he looks at the latest attempts to make artificial blood.
Douglas Starr has written a groundbreaking book that tackles a subject of universal and urgent importance and explores the perils and promises that lie ahead.
This well-known handbook presents the experience of a world leader in the field of blood banking and transfusion therapy. Transfusion Medicine offers complete guidance on the full range of topics from donor recruitment, blood collection and storage, to testing and transfusing blood components, complications and transmissible diseases, as well as cellular engineering, therapeutic apheresis, and the role of hematopoietic growth factors.
This third edition includes updated information on a number of areas including:Current debate on clinical effects of stored red blood cells Emerging infectious diseases and impact on blood safety New concepts of massive transfusion World blood supply Platelet transfusion Pathogen inactivation
Transfusion Medicine will be valuable to all those working in the field of blood banking and transfusion. It is a good introduction to transfusion for hematology or oncology fellows and technologists specialising in blood banking.
This new edition of Haematology at a Glance:
• Features expanded sections on the underlying mechanisms, diagnostic techniques and management of the malignant haematological diseases. Also incorporates recent advances in knowledge of thrombosis and the newer oral anticoagulants
• Contains the very latest clinical treatments
• Includes updated illustrations and clinical photographs to illustrate concepts and aid understanding
• Features extensive online self-assessment at www.ataglanceseries.com/haematology
This book is an invaluable resource for medical students and health professionals wanting to consolidate and expand their knowledge of haematology.
Enables both the haematologist and laboratory scientist to identify blood cell features, from the most common to the more obscure
Provides essential information on methods of collection, blood film preparation and staining, together with the principles of manual and automated blood counts
Completely revised and updated, incorporating much newly published information: now includes advice on further tests when a specific diagnosis is suspected
Four hundred high quality photographs to aid with blood cell identification
Highlights the purpose and clinical relevance of haematology laboratory tests throughout
Taking a unique multi-disciplinary approach, the book covers conventional histopathology and cytopathology, as well as all important complementary diagnostic tests, such as immunophenotyping (immunohistochemical stains and flow cytometry), karyotyping, FISH and DNA/molecular studies. It offers concise textual and extensive visual coverage of both neoplastic and non-neoplastic hematology disorders, with the neoplastic hematology sections presented according to the most recent WHO classifications. There is also an introduction to the normal structures of hematopoietic tissues and the various multidisciplinary techniques.
The atlas contains more than 900 high-quality color images that mirror the findings that fellows and clinicians encounter in practice. It provides information in a quick, simple and user-friendly manner, attracting those who are in training or are not considered experts in the field. Residents, fellows, practicing clinicians, and researchers in pathology, hematology, hematology/oncology, as well as graduate students in pathology and other clinicians workings in clinical hematology laboratories will all find it useful.Saves clinicians and researchers time in quickly accessing the very latest details on the diverse clinical and scientific aspects of hematopathology, as opposed to searching through thousands of journal articles For clinicians, fellows, and residents, correct diagnosis (and therefore correct treatment) of diseases depends on a strong understanding of the molecular basis for the disease – hematologists, pathologists, oncologists, and other clinicians will benefit from this clear, focused, annotated format
Companion web site features over 900 images from the book!
At thirty-one David biro has just completed his residency and joined his father's successful dermatology practice. Struck with a rare blood disease that eventually necessitates a bone marrow transplant, Biro relates with honesty and courage the story of his most transforming journey. He is forthright about the advantages that his status as a physician may have afforded him; and yet no such advantage can protect him from the anxiety and doubt brought on by his debilitating therapies. The pressures that Biro's wild "one hundred days" brings to bear on his heretofore well-established identity as a caregiver are enormous--as is the power of this riveting story of survival.
From the Trade Paperback edition.
The first main part of the book is subdivided into blood banking and transfusion medicine. Under blood banking, the chapters cover blood collection, donation process, component manufacturing, donor testing and storage; transfusion-medicine chapters examine the components for transfusion, pre-transfusion immunohematology testing, blood groups, blood products and their modifications, approaches to transfusion therapy in specific clinical settings, and transfusion reactions and complications. In addition, chapters that talk about apheresis, cellular therapy, and tissue banking in the hospital setting are included.
Hemostasis, the second main part of the book, is subdivided into three sections. The first section, clinical coagulation, includes chapters about neonatal thrombocytopenia, inherited platelet function disorders, immune thrombocytopenia, immune-mediated coagulopathies, congenital bleeding disorders, and acquired bleeding disorders. The second section relates to laboratory testing of coagulation, with chapters about laboratory assessments of platelet disorders, von Willebrand disease, coagulation factor disorders, fibrinogen and fibrinolysis, tests for hypercoagulable state and for activation of the coagulation system, and laboratory support for anticoagulation. The third section discusses coagulation factor products.
This book will be valuable for the education of trainees, practitioners, and future leaders in these fields.
Written by experts in the field, Immunohematology and Transfusion Medicine: A Case Study Approach provides an interactive tool to help make blood banking and transfusion medicine memorable, practical, and relevant to residents and fellows.
Over five editions Postgraduate Haematology has built a reputation as an extremely practical, user-friendly, reliable source of information for examination preparation and clinical practice. Completely revised to reflect the latest research in the field, this edition continues to provide trainees with up-to-date knowledge on the pathogenesis, clinical and laboratory features, and management of blood disorders. It covers the significant advances which have occurred in the application of cytogenetics and molecular genetics in the diagnosis, classification and understanding of haematological disorders.
Coupled with the expertise of 34 new contributors from across Europe, the editors have been joined by Professor Anthony Green, from the University of Cambridge, and they have reorganised the book into 52 accessible chapters.
Postgraduate Haematology is richly illustrated throughout with over 450 colour illustrations including line drawings, photomicrographs of blood cells and tissues, and algorithms to help aid treatment decision making. It is an indispensable resource for trainees and an essential read for all specialists who are interested in updating their knowledge.
Companion resources site for this book:
with:Figures and tables from the book for downloading Interactive multiple-choice questions
The editors have built Monoclonal Gammopathy of Undetermined Significance: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Monoclonal Gammopathy of Undetermined Significance in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Monoclonal Gammopathy of Undetermined Significance: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility.
The editors have built Sickle Cell Anemia: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Sickle Cell Anemia: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility.
The editors have built Hemoglobinopathies—Advances in Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Hemoglobinopathies—Advances in Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility.
This fourth edition:Incorporates the recommendations of the 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues Covers key diagnostic techniques such as flow cytometric immunophenotyping, immunohistochemistry and cytogenetic and molecular genetic analysis Includes new diagnostic algorithms and summary boxes Contains 550 colour illustrations including high-quality digital photomicrographs
Haematologists and histopathologists will find this book an invaluable desktop reference when performing daily blood and bone marrow investigations.
This unique and practical book introduces the reader to the concept of blood management and explains how to improve patient outcomes by avoiding undue blood loss, enhancing the patient’s own blood, effective management of anemia and coagulopathy. Basics of Blood Management is the first book dedicated to blood management, a multidisciplinary and multimodality concept that focuses on patient outcome.
A practical and comprehensive text on the new and exciting field of blood management
Takes an international perspective, covering conditions encountered in developing and industrial countries
Covers all areas of organization, methods and tools
Gives the reader an understanding of the concept and philosophy of blood management
Provides clinical scenarios and exercises that help the reader to adapt information for their location
Whether you are an early practising clinician in hematology, transfusion, critical care, anesthesiology, surgery or internal medicine, a nursing specialist, trainee or other member of the multidisciplinary blood management team, this book will answer all your questions about blood management as an aid in improving patient outcome.
Filling an unmet need in the clinical literature, this commanding, just-in-time reference sheds light on the full spectrum of cancers in the blood, bone marrow, and lymphatic system (leukemia, lymphoma, myeloma). Clinical Malignant Hematology is edited by staff members from the renowned Taussig Cancer Center at the Cleveland Clinic, which has pioneered some of the most important clinical discoveries and treatment trends in recent years.
Look inside and you'll see a consistent, unified patient management strategy in each chapter, as well as a streamlined three-section format that expertly examines ontogeny and physiology of blood cells, myeloid neoplasia, and lymphoid neoplasia. You'll also find never-before-published perspectives and precise recommendations for dosing and other critical areas that reflect the latest scholarship of this increasingly vital field.
FeaturesFull coverage of all treatment modalities-chemotherapy, monoclonal antibodies, and hematopoietic stem cell transplantation Strong background chapters that offer guidance on how to address treatment complications and other supportive care issues A detailed, regimen-based orientation in each chapter Abundance of clinical pictures and photomicrographs displaying examples of peripheral blood smears and bone marrow aspirates Uniform headings and tables in each chapter, which convey specific recommendations on the work-up, staging, diagnosis, differential diagnosis, and treatment of hematologic malignancies Nearly 200 illustrations
Modern Hematology: Biology and Clinical Management, Second Edition brings together facts, concepts, and protocols important for the practice of hematology. In 23 chapters, all major blood diseases are covered, as well as rare diseases that are of scientific interest. The first two chapters introduce the reader to the scientific basis of blood disorders. As in the previous edition, each chapter is illustrated by tables, figures, and a selection of color plates. Experts in pediatric hematology, myeloma, blood transfusion, hemoglobinopathies, pharmacology, and infectious diseases have expanded the scope of Modern Hematology.
Comprehensive and informative, Modern Hematology: Biology and Clinical Management, Second Edition is an invaluable resource for medical students, hematology trainees, residents, nurses, nurse practitioners, and physicians in other specialties treating patients with benign and malignant blood disorders.
The practical objective of this book is to establish guidelines for the management of endocrine disorders underlying the various phases of thalassemic life. Internationally acknowledged experts give a state-of-the-art account of physiopathological and therapeutical approaches to endocrine disorders in thalassemia and focus on such topics as growth hormones, thyroid diseases, puberty, hypogonadism, diabetes, and bone metabolism.
The editors have built Thalassemia: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Thalassemia in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Thalassemia: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility.
Comprehensive and up-to-date, Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Practice offers an integrated survey of the role of HGFs in treating and preventing anemia, neutropenia, and thrombocytopenia in patients with malignant and nonmalignant diseases, along with fresh insights into drug development and how basic discoveries in this area can be optimally translated into clinical benefit.
Hughes Syndrome addresses the complete range of features produced by this common disorder, which is also known as antiphospholipid syndrome. The condition can affect any organ, and is treated using commonly available drugs including low-dose aspirin and warfarin. This timely book fulfils the need for a cross-disciplinary clinical textbook and contains contributions from the leading international authorities.
Hughes Syndrome should be read by anyone who might have a clinical or scientific interest in this condition: rheumatologists, haematologists, obstetricians and neurologists.
Lanzkowsky’s Manual of Pediatric Hematology and Oncology, Sixth Edition,is a comprehensive book on patient management, replete with algorithms and flow diagrams on diagnosis and management. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the sixth edition of this successful clinical manual has been entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format will enable readers to make accurate diagnoses and permit them to treat patients without having to reference larger medical textbooks.
Based on the new standards of genetic classification and prognostic information that have arisen in the past five years, the sixth edition includes two new chapters (Diagnostic, Molecular, and Genomic Methodologies for the Hematologist, Transfusion Medicine) and several new expanded chapters that were previously sections in consolidated chapters (Myelodysplasia, Myeloid Leukemias, Lymphoid Leukemias, Hemolytic Anemia, and Disorders of Coagulation).Presents a concise, systematic approach to all pediatric hematologic and oncologic disorders in one manualOffers an alternative to bigger references which only cover either oncologic or hematologic disorders in twice as many pagesPresents an easy-to-read format: multiple tables, charts, and flow-diagrams for diagnosis and management of pediatric hematologic and oncologic disordersIncludes 2 new chapters and several expanded chapters: Diagnostic, Molecular and Genomic Methodologies for the Hematologist, Transfusion Medicine, Myelodysplasia, Myeloid Leukemias, and Lymphoid Leukemias
Microscopic Haematology, 3rd Edition: A practical guide for the laboratory has been fully updated in line with the current World Health Organisation classification.
In addition to providing a wealth of information on haematology, this excellent textbook for health professionals includes over 400 full colour haematological slides.
Microscopic Haematology, 3rd Edition: A practical guide for the laboratory is arranged in a logical, easy-to-follow order.
The guide commences with the red cell series and describes normoblastic erythropoiesis, abnormal erythropoiesis and all the red cell disorders associated with anaemia.
Each type of anaemia is described with minimal text and is accompanied by coloured haematological slides depicting red cell changes associated with the particular disorder. The platelet section adheres to the same format.
Microscopic Haematology, 3rd Edition: A practical guide for the laboratory also offers a section on paediatric haematology, outlining red cell, white cell and platelet disorders occurring in cord blood, the neonate and childhood.
The final section in this expansive health reference focuses on blood parasites and describes the four species of human malaria.
A description of characteristic features in each species as it occurs in the red cell is accompanied by images depicting the various stages of maturation of each malaria species.
Elsevier’s Evolve website provides an extensive ancillary package for students and lecturers, including • downloadable student content specific to Haematology I and II • interactive case studies for students with multiple choice questions for self directed learning • 17 detailed case studies to help lecturers develop differential diagnosis skills and problem solving skills with model answers • an image bank for lecturers• a thorough paediatrics section describing red cell, white cell and platelet disorders
• over 400 high quality images magnified x 1000
• 30 detailed haematological case studies (online)
• a list of common haematology-related abbreviations
• an online image bank
• expanded coverage of blood cell production, haematopoiesis and disease physiology
• detailed case studies for both adult and paediatric conditions (online)
• approximately 90 new images showing cell morphology and cell ultrastructures
• a comprehensive online teaching and learning package
• aligned with the current World Health Organisation classification standard
The label Aspergillosis is used for several diverse clinical conditions. For instance, invasive Aspergillosis typically affects severely immunocompromised patients such as those with prolonged neutropenia or receiving therapy with steroids. On the other hand, allergic forms of Aspergillosis cause exuberant clinical syndromes that mostly affect patients with asthma and cystic fibrosis. Slowly destructive lung diseases may also occur in the apparently immunocompentent host, especially in the context of previous damage to the lung architecture. These are difficult-to-diagnose infections, and diagnostic tests perform differently depending on the specific scenario.
This book summarizes the current knowledge about Aspergillosis, covering:
Epidemiology Pathogenesis Clinical manifestations Diagnosis Treatment Prevention
Written by internationally respected authors, the information presented in this book adds for a better understanding of Aspergillosis by providing a comprehensive and clear overview of all aspects associated with this complex disease.
Bob Massie was born with classical hemophilia, a painful disorder that caused repeated bleeding in his joints and slowly robbed him of the ability to walk. Though bound to leg braces and wheelchairs as a child, his curiosity and enthusiasm pulled him relentlessly outward toward knowledge and people. Gradually he fought back and eventually succeeded not only in walking again but in traveling widely through a life of passion and commitment. He graduated in history from Princeton, where he organized the opening up of the university's exclusive club system, and later was ordained as an Episcopal minister. After several years teaching children and working with the homeless in New York City, he moved to the challenging halls of Harvard Business School, where he earned a doctorate while tending to a devoted but struggling congregation in the working-class city of Somerville, Massachusetts.
Though the medical dangers increased—he had acquired the HIV and hepatitis through transfusions for hemophilia—he continued to press for justice. He wrote a prizewinning book on South African apartheid, led one of America's most innovative environmental groups, ran for lieutenant governor in Massachusetts, and created the world's leading standard for corporate sustainability. Then, in 2002, the same year Massie was named one of the 100 most influential people in the field of finance by CFO magazine, he received more devastating health news. The hepatitis was causing his liver to fail, and Massie was brought close to death in 2009.
After surviving these remarkable challenges, Bob Massie is now ready to share his story. Though his journey has not been easy, he writes about it with tremendous grace and candor. In an era rife with disillusionment, A Song in the Night will inspire everyone who reads it.
"A good friend and a visionary leader, Bob Massie has combined foresight, passion, and skill to create lasting change in the US and around the world. In A Song in the Night, Bob shares deeply personal stories that help describe how he overcame great challenges to forge such strong commitments for his work and family. Bob has lived an incredible life, and we are so fortunate that he has shared it with us in this wonderful new book." —Al Gore
"I admire and deeply respect Bob Massie’s courage, his compassion, and his eloquence. He is a good man. His life's work has focused on social justice, public service, and faith, and I know he will continue to work tirelessly to make this a more just world." —Elizabeth Warren
From the Hardcover edition.
Designed for medical students, residents, and fellows, this user-friendly portable reference is also the perfect companion on the ward for pediatric hematology and oncology nurses.
Each day pathologists are faced with ordering laboratory tests with which they are unfamiliar. An incorrectly ordered test or error in interpreting test results can lead to mistakes that compromise patient safety.
Coagulation Disorders is designed to show clinical pathologists, lab managers, medical technologists, and residents how to avoid common errors in test selection and result interpretation in diagnostic coagulation. Utilizing a case-based approach, each chapter features a concise overview of a major diagnosis, with multiple illustrative cases, and then a list of recommended standards of care pertinent to the problem.
Just as it is essential for the practitioner in the diagnosis of bleeding and thrombotic disorders to know the appropriate course of action to establish a diagnosis or to appropriately treat a patient, it is equally essential to also know what not to do. Avoiding the mistakes is a critical first step to optimizing patient outcome and maximizing patient safety.
Features of Coagulation Disorders include: An emphasis on identifying established, evidence-based standards in coagulation testing Actual case illustrations of commonly seen errors as well as the result of those errors on patient outcome and laboratory management Examples of errors which compromise patient safety across all major areas of laboratory medicine Pocket-sized for portability
About the Series
A key issue for every laboratory and individual laboratory practitioner is the assessment of risk and a current working knowledge of the standards of care established for diagnostic testing via guidelines, major studies and trials. The Diagnostic Standards of Care series presents common errors associated with diagnoses in clinical pathology, using case examples to illustrate effective analysis based on current evidence and standards. In addition to being practical diagnostic guides, each volume demonstrates the use of quality assurance and the role of the pathologist in ensuring quality and patient safety."
An essential tool for providers, this guide presents a multidisciplinary approach to information you will need to provide quality care for your patients.