The book is meant for serious students of arrhythmias, be they cardiology or electrophysiology trainees or established physicians.
Nessa Carey, a leading epigenetics researcher, connects the field’s arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.
The new fourth edition has been thoroughly revised and updated to reflect the many advances in science and technology, including the five accepted sequential stages of micropropagation. Ten new plants have been added. This in turn has greatly expanded the already extensive bibliography. Among the new topics that have been introduced or expanded on are embryo culture for breeding, somaclonal variation, anther culture, somatic embryogenesis, cryopreservation, and genetic engineering. More ornamental plant examples are given and many new illustrations provided, including a chronology of discoveries in micropropagation.
This could be a description of a human army. It happens, however, to be a description of an army of cancer cells. Most of us shrink from describing bacteria and other microorganisms as intelligent. Neurosurgeon Frank Vertosick does not. And perhaps, when you finish reading MIND: A UNIFIED THEORY OF LIFE AND INTELLIGENCE, you will not either.
What is intelligence? We define it in human terms, but are humans the only measure? We ascribe it to higher mammals and to social insects like bees and ants, but when we cross the threshold into cellular life, definitions blur. This revolutionary–but accessible and highly entertaining–exploration of intelligence is guaranteed to alter your appreciation of life on its most fundamental level.
Frank T. Vertosick, J.R., M.D. is the author of WHEN AIR HITS YOUR BRAIN and WHY WE HURT: THE NATURAL HISTORY OF PAIN
(Originally published as THE GENIUS WITHIN)
A number of ethical issues related to stem cells that spark debates are discussed, including risky treatments, cloning and embryonic stem cells. The author breaks new ground in a number of ways such as by suggesting reforms to the FDA, providing a new theory of aging based on stem cells, and including a revolutionary Stem Cell Patient Bill of Rights. More generally, the book is your guide to where the stem cell field will be in the near future as well as a thoughtful perspective on how stem cell therapies will ultimately change your life and our world.Contents:Meet Your Stem CellsThe Types of Stem Cells and Their Clinical PotentialStem Cell Treatments: Applications and ObstaclesStem Cell Models: Past, Present, and FutureAll in the Family: An Insider's Tale of Two Stem Cells and a Black SheepAging: The Stem Cell ConnectionLaw and Order Stem CellsStem Cells for Profit: An Ethical SpectrumPatient Bill of Rights and Guide to Stem Cell TreatmentsAre We There Yet? How Stem Cells Might Work to Treat Specific DiseasesStem Cell Cosmetics: More Than Skin Deep?Stem Cell Tests for HumanityGetting Your Stem Cell Geek OnConclusion: The Future of Stem Cells
Readership: A wide range of readers: patients, scientists, biotech and big pharma people, students, investors, lawyers, employees of funding agencies such as the National Institute for Health (NIH) and the California stem cell agency, the US Food and Drug Administration (FDA), and researchers.
Keywords:Stem Cells;Stem Cell Treatments;Adult Stem Cells;Embryonic Stem Cells;Ips Cells;Stem Cell Tourism;Aging;Cancer;Medicine;Regenerative Medicine;Anti-AgingKey Features:Novel insider' guide to stem cells giving people an exciting look into the world of stem cells and stem cell researchTackles practical issues related to stem cell treatments including cosmetics and sports medicine, areas of intense interest to the publicWritten by a stem cell scientist and cancer survivor who can see health-related issues from both perspectives as patient and professorReviews:
“This is an opinionated but extremely knowledgeable introduction to the potentials and pitfalls of research in and applications of stem cells. The science is current, accessible, and well presented, but the best aspect of the book is its focus on ethical considerations associated with stem cell research. This is a fascinating book on important scientific, medical and consumer issues.”CHOICE
This book brings about the confluence of concepts and tools, and that of different disciplines, to address significant problems of our time: visualization; theory and computation for complexity; macromolecular function, protein folding and misfolding; and systems integration from cells to consciousness. The scope of tools is wide-ranging, spanning imaging, crystallography, microfluidics, single-molecule spectroscopy, and synthetic probe targeting. Concepts such as dynamic self-assembly, molecular recognition, non-canonical amino acids, and others are covered in various chapters as they are cornerstones in building the trilogy description of behavior-structure, dynamics, and function.
The volume is uniquely structured to provide overviews with historical perspectives on the evolution of ideas and on the future of physical biology and biological complexity, from atoms to medicine.Contents: The Preoccupations of Twenty-First-Century Biology (D Baltimore)The World as Physics, Mathematics and Nothing Else (A Varshavsky)Physical Biology: 4D Visualization of Complexity (A H Zewail)Revolutionary Developments from Atomic to Extended Structural Imaging (J M Thomas)Physical Biology at the Crossroads (C Bustamante)The Challenge of Quasi-Regular Structures in Biology (R D Kornberg)The Future of Biological X-Ray Analysis (D C Rees)Reinterpreting the Genetic Code: Implications for Macromolecular Design, Evolution and Analysis (D A Tirrell)Designing Ligands to Bind Tightly to Proteins (G M Whitesides et al.)Biology by the Numbers (R Phillips)Eppur si muove (M Parrinello)Protein Folding and Beyond: Energy Landscapes and the Organization of Living Matter in Time and Space (P G Wolynes)Protein Folding and Misfolding: From Atoms to Organisms (C M Dobson)A Systems Approach to Medicine Will Transform Healthcare (L Hood)The Neurobiology of Consciousness (C Koch & F Mormann)Computer-Aided Drug Discovery: Physics-based Simulations from the Molecular to the Cellular Level (J A McCammom)Precision Measurements in Biology (S R Quake)Potassium Channels and the Atomic Basis of Selective Ion Conduction (R MacKinnon)Symmetry Breaking, Delocalization and Dynamics in Electron Transfer Systems (N S Hush)The Initial Value Representation of Semiclassical Theory: A Practical Way for Adding Quantum Effects to Classical Molecular Dynamics Simulations of Complex Molecular Systems (W H Miller)
Readership: Graduate students and researchers in life sciences (structural biology, genomics, systems biology, molecular biology, neuroscience), biochemistry, physical chemistry, chemical engineering, and biophysics.
Keywords:Visualization;Complexity;Macromolecular Function;Protein Folding;Molecular Recognition;Systems Integration;Cells;Consciousness;Crystallography;Microfluidics;Spectroscopy;Synthetic Probe TargetingReviews:“Even the shorter contributions, written by masters of their fields, are penetrating.”Chemistry World
“The scope of this collection of overviews of the present state and future possible developments in physical biology is very broad. The result is both informative and readable. Anyone interested in how physics, engineering and mathematics can contribute to research in biology and medicine, be it on the molecular level or on the healthcare level, should be able to find useful information and inspiration in this book.”Acta Paediatrica
This thoroughly revised version includes chapters on general physiology as well as cardiovascular, respiratory, renal, gastrointestinal, endocrine, central nervous system, and integrative physiology. It contains clinical notes, chapter outlines with page numbers, 2-color figures throughout, and new chapters on Exercise, Diabetic Ketoacidosis, and Maternal Adaptations in Pregnancy.
Among the contributors to this indispensible textbook are leading physiologists Leonard R. Johnson, Stanley G. Schultz, H. Maurice Goodman, John H. Byrne, Norman W. Weisbrodt, James M. Downey, D. Neil Granger, Frank L. Powell, Jr., James A. Schafer, and Dianna A. Johnson.
This text is recommended for medical, graduate, and advanced undergraduate students studying physiology, physicians, and clinical specialists as well as anyone interested in basic human physiology.
* Includes clinical notes
* "Key Points" summarize most important information
* Contains chapter outlines with page numbers
* 2-color figures throughout
* New chapters on Exercise, Diabetic Ketoacidosis, and Maternal Adaptations in Pregnancy
The latest developments in the field are included and key concepts introduced in a user-friendly way to ensure that students are able to grasp the essentials before moving on to more advanced study and analysis of proteins.
An invaluable resource for students of Biochemistry, Molecular Biology, Medicine and Chemistry providing a modern approach to the subject of Proteins.
This book is a sequel to The Rainbow and The Worm, The Physics of Organisms, which has remained in a class of its own for nearly 20 years since the publication of the first edition. Living Rainbow H2O continues the fascinating journey in the author's quest for the meaning of life, in science and beyond. Like The Rainbow and The Worm, the present book will appeal to readers in the arts and humanities as well as scientists; not least because the author herself is an occasional artist and poet. Great care has been taken to explain terms and concepts for the benefit of the general reader. At the same time, sufficient scientific details are provided in text boxes for the advanced reader and researcher without interrupting the main story.
Chapter 1: Rainbow Dancing in the Worm (299 KB)
Contents:Rainbow Dancing in the WormWeird and Wonderful WaterCooperative Coherent WaterWater and Colloid Crystals: The New Age of AlchemyQuantum Coherent WaterQED Water IQED Water II: Non-thermal EMF EffectsQED Water III: HomeopathyDancing with IonsDancing with ProteinsDancing with DNAWater at Solid InterfacesWater ElectricWater + Air = LifeWater Meets AirWater Meets MembranesThe Rainbow EnsembleTrue Portrait of the CellWater in NanospaceProtein and Water in NanospaceFire and WaterWater Fuels the Dynamo of LifeElectronic Induction Animates Life
Readership: General public and undergraduate students in cell biology, biophysics, biochemistry and quantum mechanics.
Keywords:Liquid Crystalline Water;Quantum Coherence;Quantum Cell BiologyKey Features:There is no competing title, or even comparable book in existenceIt is fit for the general reader with no more background than school science as well as the advanced researcher in the fieldIt tells an exciting, and evocative story of water in living cells and organisms that is also completely newReviews:
"This book is a delightful read for laypersons. It surveys some of the outstanding, sometimes considered anomalous properties of water and aqueous solutions. The style is consistently light, as it hops from one topic to another with a seemingly dance-like rhythm to it. Indeed, one finds many dances of water molecules among themselves, as well as with other molecules in living cells … I recommend this book to anyone who is curious about what goes on in each of our cells, and why water is so vital to our life."Arieh Ben-Naim
Hebrew University of Jerusalem, Israel
For more than three decades, Junqueira's Basic Histology has been unmatched in its ability to explain the function of cell and tissue structure in the human body. Updated to reflect the latest research in the field, and enhanced with more than 1,000 illustrations, most in full-color, the Fourteenth Edition reflects the most comprehensive and modern approach to understanding medical histology available anywhere. This well-regarded classic is distinguished by chapters focusing on the cytoplasmic and nuclear compartment of the cell, the four basic tissues that form the organs, and each organ system.
In response to reader demand, the legends are now concise, stand-alone summaries of the illustrations. Applauded for its visual appeal, Junqueira’s is enhanced by full-color micrographs that comprise a complete atlas of tissue sections. These state-of-the-art micrographs highlight the important features of every tissue and organ in the human body, while full-color, easy-to-understand drawings provide just the right level of detail necessary to clarify the text and make learning easier.
For decades, scientists have been using “HeLa” cells in biological research, from developing the polio vaccine and studying the nature of cancer to observing how human biology behaves in outer space. This famous cell line began as a sample taken from a poor African American mother of five named Henrietta Lacks.
A cancer patient, Henrietta Lacks went through medical testing but never gave consent for the use of her cells. She died of cervical cancer in 1951, without ever knowing that the samples were intended for extensive medical research.
This summary of the #1 New York Times bestseller by Rebecca Skloot tells Henrietta’s story and reveals what happened when her family found out that her cells were being bought and sold in labs around the world.
With historical context, character profiles, a timeline of key events, and other features, this summary and analysis of The Immortal Life of Henrietta Lacks is intended to complement your reading experience and bring you closer to a great work of nonfiction.
Contributions come from leading voices in cell biology, who are defining the future of their field, including: - Tom Misteli, National Cancer Institute - Galit Lahav, Harvard Medical School - Scott D. Emr, Cornell University - David G. Drubin, University of California, Berkeley - Tom Rapoport, Harvard Medical School - Anthony A. Hyman, Max Planck Institute of Molecular and Cell Biology, Dresden
This publication is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals.Provides timely, comprehensive coverage across a broad range of cell biological topicsOffers foundational knowledge and expert insights to students and others new to the fieldFeatures reviews from leaders in cell biology research and discussion of future directions for the fieldIncludes articles originally published in Cell, Current Biology, Developmental Cell, and Trends in Cell Biology
Covering mitochondria, bacteria and chloroplasts, the fourth edition of Bioenergetics provides a clear and comprehensive account of the chemiosmotic theory and its many applications. The figures have been carefully designed to be memorable and to convey the key functional and mechanistic information. Written for students and researchers alike, Bioenergetics is the most well-known, current and respected text on chemiosmotic theory and membrane bioenergetics available.BMA Medical Book Awards 2014-Highly Commended, Basic and Clinical Sciences,2014,British Medical AssociationChapters are now divided between three interlocking sections: basic principles, structures and mechanisms, and mitochondrial physiology. Covers new advances in the structure and mechanism of key bioenergetic proteins, including complex I of the respiratory chain and transport proteins.Details cellular bioenergetics, mitochondrial cell biology and signal transduction, and the roles of mitochondria in physiology, disease and aging.Offers readers clear, visual representation of structural concepts through full colour figures throughout the book.
The book maintains a concise focus on eukaryotic cell biology as it relates to human and animal disease, all within a manageable 300-page format. This is accomplished by explaining general cell biology principles in the context of organ systems and disease.
This updated version contains 60% new material and all new clinical cases. New topics include apoptosis and cell death from a neural perspective; signal transduction as it relates to normal and abnormal heart function; and cell cycle and cell division related to cancer biology.60% New Material!New Topics include: Apoptosis and cell dealth from a neural perspectiveSignal transduction as it relates to normal and abnormal heart functionCell cycle and cell division related to cancer biologyAll new clinical cases Serves as a prep guide to the National Medical Board Exam with sample board-style questions (using Exam Master(R) technology): www.exammaster.com Focuses on eukaryotic cell biology as it related to human disease, thus making the subject more accessible to pre-med and pre-health students
Making PCR explores the culture of biotechnology as it emerged at Certus Corporation during the 1980s and focuses on its distinctive configuration of scientific, technical, social, economic, political, and legal elements, each of which had its own separate trajectory over the preceding decade. The book contains interviews with the remarkable cast of characters who made PCR, including Kary Mullin, the maverick who received the Nobel prize for "discovering" it, as well as the team of young scientists and the company's business leaders.
This book shows how a contingently assembled practice emerged, composed of distinctive subjects, the site where they worked, and the object they invented.
"Paul Rabinow paints a . . . picture of the process of discovery in Making PCR: A Story of Biotechnology [and] teases out every possible detail. . . . Makes for an intriguing read that raises many questions about our understanding of the twisting process of discovery itself."—David Bradley, New Scientist
"Rabinow's book belongs to a burgeoning genre: ethnographic studies of what scientists actually do in the lab. . . . A bold move."—Daniel Zalewski, Lingua Franca
"[Making PCR is] exotic territory, biomedical research, explored. . . . Rabinow describes a dance: the immigration and repatriation of scientists to and from the academic and business worlds."—Nancy Maull, New York Times Book Review
Contributions come from leading voices in the field, including: - Daniel A. Haber, Director of Massachusetts General Hospital Cancer Center and Professor at Harvard Medical School - Tony Kouzarides, Professor at the University of Cambridge, Deputy Director of the Wellcome Trust/Cancer Research UK Gurdon Institute, and a founder of the cancer drug discovery company Chroma Therapeutics - Charles L. Sawyers, Chair of the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, President of the American Association for Cancer Research, member of the presidentially appointed National Cancer Advisory Board, and recipient of the 2013 Breakthrough Prize in Life Sciences
Cell Press Reviews: Cancer Therapeutics is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals.Provides timely, comprehensive articles on a wide range of topics in cancer therapeuticsOffers insight from experts on genetic, molecular, and cellular aspects of cancer therapyFeatures reviews on basic science advances translated into drug discovery and therapeutic approachesIncludes articles originally published in Cell, Cancer Cell, Trends in Genetics, Trends in Molecular Medicine, and Trends in Pharmacological Sciences
Two patients—each known in medical history as the Berlin Patient—were cured of the HIV virus. The two patients’ disparate cures came twelve years apart, but Nathalia Holt, an award-winning scientist at the forefront of HIV research, connects the molecular dots of these cases for the first time.
Scientists are known to maintain a professional distance from those they study, but sometimes scientists are not just investigators, they are caregivers, too. Cured illustrates that even in the era of high-tech and big pharma, the way doctors and patients communicate remains a critical ingredient in the advance of this science. Holt offers a kind of hope that the thirty-four million people currently infected with HIV need and a story of ingenuity, dedication, and humanity that will inspire the rest of us.
In this book, more than 50 worldwide invasion scientists cover our current understanding of biological invasions, its impacts, patterns and mechanisms in both aquatic and terrestrial systems.
As technology-driven approaches like FISH and aCGH have yet to achieve the promise of universal coverage or cost efficacy to sample investigated, deep chromosome analysis and molecular cytogenetics remains relevant for technology translation, study design, and therapeutic assessment.
Knowledge of the rare but recurrent rearrangements unfamiliar to practitioners saves time and money for molecular cytogeneticists and genetics counselors, helping to distinguish benign from harmful CG-CNV. It also supports them in deciding which molecular cytogenetics tools to deploy.Shows how to define the inheritance and formation of cytogenetically visible copy number variations using cytogenetic and molecular approaches for genetic diagnostics, patient counseling, and treatment plan developmentUniquely classifies all known variants by chromosomal origin, saving time and money for researchers in reviewing benign and pathologic variants before costly molecular methods are used to investigateSide-by-side comparison of copy number variants with their recently identified submicroscopic form, aiding technology assessment using aCGH and other techniques
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of revolutionary gene therapy strategies. In this advanced textbook, more than 25 leading scientists, world-renowned in their respective fields, come together to provide a clear and comprehensive description of gene delivery, gene therapy and genetic pharmacology.
This educational introduction to the main gene transfer vectors and selected therapeutic applications provides the background material needed to further explore the subject as well as relevant research literature. It will thus be invaluable to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide, or develop a gene therapy strategy. Furthermore, the textbook's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.Contents:Basic Definitions and Principles:Introduction (Thierry VandenDriessche)Basic Definitions and General Principles (Daniel Scherman)History of Gene Therapy (Serge Braun)Genetic Pharmacology Using Synthetic Deoxyribonucleotides (Jean-Christophe François and Carine Giovannangeli)Principles of RNAi Trigger Expression for Gene Therapy (Lisa J Scherer and John J Rossi)On Demand Alternative Splicing for Gene Rescue (Stéphanie Lorain and Luis Garcia)Nuclease-Mediated Targeted Genetic Correction (Dieter C Gruenert, Hamid Emamekhoo and R Geoffrey Sargent)Vectors and Gene Delivery Techniques:γ-Retrovirus- and Lentivirus-Derived Vectors for Gene Transfer and Therapy (Caroline Duros and Odile Cohen-Haguenauer)Adenovirus Vectors (Stefan Kochanek)Adeno-Associated Virus (AAV) Vectors (Aurélie Ploquin, Hildegard Büning and Anna Salvetti)Herpes Simplex Virus (HSV-1)-Based Vectors: Applications for Gene Transfer, Gene Therapy, Cancer Virotherapy and Vaccination (Matias E Melendez, Aldo Pourchet, Anna Greco and Alberto L Epstein)Non-Viral DNA Vectors (Martin Schleef)Macromolecular Conjugates for Non-Viral Nucleic Acid Delivery (Mark Ericson, Kevin Rice and Guy Zuber)Auto-Associative Lipid-Based Systems for Non-Viral Nucleic Acid Delivery (Virginie Escriou, Nathalie Mignet and Andrew Miller)Hydrodynamic-Pressure-Based Non-Viral Nucleic Acid Delivery (Takeshi Suda, Kenya Kamimura, Guisheng Zhang and Dexi Liu)Electrotransfer/Electroporation for Non-Viral Nucleic Acid Delivery (Pascal Bigey, Richard Heller and Daniel Scherman)Imaging of Gene Delivery (Georges Vassaux, Peggy Richard-Fiardo, Béatrice Cambien and Philippe Franken)Therapeutic Applications:Oncolytic Adenoviruses for Cancer Gene Therapy (Gunnel Hallden, Yaohe Wang, Han-Hsi Wong and Nick R Lemoine)Progress in DNA Vaccine Approaches for Cancer Immunotherapy (Geoffrey D Hannigan and David B Weiner)Gene Therapy of the Beta-Hemoglobinopathies (Emmanuel Payen, Charlotte Colomb, Olivier Negre, Marina Cavazzana-Calvo, Salima Hacein-Bey-Abina, Yves Beuzard and Philippe Leboulch)Gene Therapy for Hemophilia A and B (Nisha Nair, Marinee Chuah and Thierry VandenDriessche)Experimental and Clinical Ocular Gene Therapy (Alexis-Pierre Bemelmans and José-Alain Sahel)Gene Therapy of Neurological Diseases (Lisa M Stanek, Lamya S Shihabuddin and Seng H Cheng)Genetic Therapy of Muscle Diseases: Duchenne Muscular Dystrophy (Takis Athanasopoulos, Susan Jarmin, Helen Foster, Keith Foster, Jagjeet Kang, Taeyoung Koo, Alberto Malerba, Linda Popplewell, Daniel Scherman and George Dickson)Induced Pluripotent Stem Cells and Gene Targeting for Regenerative Medicine (Jizhong Zou and Linzhao Cheng)Gene Vector Production:Production and Purification of Viral Vectors and Safety Considerations Related to Their Use (Otto-Wilhelm Merten, Matthias Schweizer, Parminder Chahal and Amine Kamen)Production and Purification of Plasmid Vectors (Martin Schleef)
Readership: Master, PhD or MD students, post-doctoral scientists or medical doctors, and any scientists using gene transfer techniques or implementing gene therapy strategies.
Key Features:The advanced textbook addresses a broader audience of Master degree students than existing literature dedicated to more specialized scientistsThe advanced textbook might be purchased by non-specialists, such as MDs who want to follow the evolution of modern medicineThe global field of nucleotide-based therapies and nucleotide delivery are presented in this comprehensive textbook in simple words, giving easy access to key concepts and technologiesThe textbook also aims at helping non-specialized scientists choose an adequate gene transfer and/or gene therapy strategyKeywords:Gene Transfer;Gene Therapy;Gene Delivery;Genetic Pharmacology;Genetic Diseases;Vectors;Nucleotide;Therapy
The opening part covers two chapters on morphology, taxonomy, phylogeny, biosystematics, and evolutionary implications of Physarum and Didymium species. This is followed by discussions on the biological aspects of these species. These include periodic events of the mitotic cycle in Physarum polycephalum. The general characteristics of chemoreception at the membrane level using plasmodium as a model organism, as well as the structure and motility of plasmodium, are also included. The third part of the book focuses on genetic analysis of plasmodium development and the discovery of techniques for the genetic manipulation of P. polycephalum. Progress in the genetic analysis of other processes is summarized.
The concluding part examines the morphological evolution of the nucleus during the mitotic cycle together with the results from ultracytochemical and radioautographic studies. It also includes a discussion on DNA organization and replication in P. polycephalum. Finally, the synthesis and degradation of RNA in Physarum and the relationship of these biochemical processes to mitotic cycle and differentiation are tackled in the concluding chapter.
The book will serve as a frequent, single reference source to brief cell biologists on the primary research on Physarum and Didymium. It will be a good source for graduate students in cell biology, and perhaps in other graduate courses.
Covers RNA polymerases, transcriptional machinery, mechanisms of transcriptional activation, the histone code hypothesis, the epigenetic control of transcription, and combinatorial control in signaling and development
Features over 80 figures available to download online
Chapters include comprehensive reading lists, boxes highlighting theoretical concepts and experimental methods and problems designed to build and test understanding
In addition to a number of informative changes to the text throughout the book, the chapters on DNA sequencing and genome studies have been rewritten to reflect the continuing rapid developments in this area of DNA analysis:In depth description of the next generation sequencing methods and descriptions of their applications in studying genomes and transcriptomes New material on the use of ChiP-seq to locate protein-binding sites Extended coverage of the strategies used to assemble genome sequences Description of how the Neanderthal genome has been sequenced and what that sequence tells us about interbreeding between Neanderthals and Homo sapiens
Gene Cloning and DNA Analysis remains an essential introductory text to a wide range of biological sciences students; including genetics and genomics, molecular biology, biochemistry, immunology and applied biology. It is also a perfect introductory text for any professional needing to learn the basics of the subject. All libraries in universities where medical, life and biological sciences are studied and taught should have copies available on their shelves.
Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemical and biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.
* Chapter on the study of bioenergetics of mitochondria in the intact cell
* Appendix listing protein structure resources
* Additional colour plates of protein structures
* Many newly drawn illustrations
The Immunoglobulin FactsBook is the first published reference for all 203 human functional and ORF immunoglobulin genes. It is complete and standardized and employs nomenclature approved by the HUGO Nomenclature Committee.