The book is meant for serious students of arrhythmias, be they cardiology or electrophysiology trainees or established physicians.
Nessa Carey, a leading epigenetics researcher, connects the field’s arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.
The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.
The new fourth edition has been thoroughly revised and updated to reflect the many advances in science and technology, including the five accepted sequential stages of micropropagation. Ten new plants have been added. This in turn has greatly expanded the already extensive bibliography. Among the new topics that have been introduced or expanded on are embryo culture for breeding, somaclonal variation, anther culture, somatic embryogenesis, cryopreservation, and genetic engineering. More ornamental plant examples are given and many new illustrations provided, including a chronology of discoveries in micropropagation.
Two patients—each known in medical history as the Berlin Patient—were cured of the HIV virus. The two patients’ disparate cures came twelve years apart, but Nathalia Holt, an award-winning scientist at the forefront of HIV research, connects the molecular dots of these cases for the first time.
Scientists are known to maintain a professional distance from those they study, but sometimes scientists are not just investigators, they are caregivers, too. Cured illustrates that even in the era of high-tech and big pharma, the way doctors and patients communicate remains a critical ingredient in the advance of this science. Holt offers a kind of hope that the thirty-four million people currently infected with HIV need and a story of ingenuity, dedication, and humanity that will inspire the rest of us.
This could be a description of a human army. It happens, however, to be a description of an army of cancer cells. Most of us shrink from describing bacteria and other microorganisms as intelligent. Neurosurgeon Frank Vertosick does not. And perhaps, when you finish reading MIND: A UNIFIED THEORY OF LIFE AND INTELLIGENCE, you will not either.
What is intelligence? We define it in human terms, but are humans the only measure? We ascribe it to higher mammals and to social insects like bees and ants, but when we cross the threshold into cellular life, definitions blur. This revolutionary–but accessible and highly entertaining–exploration of intelligence is guaranteed to alter your appreciation of life on its most fundamental level.
Frank T. Vertosick, J.R., M.D. is the author of WHEN AIR HITS YOUR BRAIN and WHY WE HURT: THE NATURAL HISTORY OF PAIN
(Originally published as THE GENIUS WITHIN)
A number of ethical issues related to stem cells that spark debates are discussed, including risky treatments, cloning and embryonic stem cells. The author breaks new ground in a number of ways such as by suggesting reforms to the FDA, providing a new theory of aging based on stem cells, and including a revolutionary Stem Cell Patient Bill of Rights. More generally, the book is your guide to where the stem cell field will be in the near future as well as a thoughtful perspective on how stem cell therapies will ultimately change your life and our world.Contents:Meet Your Stem CellsThe Types of Stem Cells and Their Clinical PotentialStem Cell Treatments: Applications and ObstaclesStem Cell Models: Past, Present, and FutureAll in the Family: An Insider's Tale of Two Stem Cells and a Black SheepAging: The Stem Cell ConnectionLaw and Order Stem CellsStem Cells for Profit: An Ethical SpectrumPatient Bill of Rights and Guide to Stem Cell TreatmentsAre We There Yet? How Stem Cells Might Work to Treat Specific DiseasesStem Cell Cosmetics: More Than Skin Deep?Stem Cell Tests for HumanityGetting Your Stem Cell Geek OnConclusion: The Future of Stem Cells
Readership: A wide range of readers: patients, scientists, biotech and big pharma people, students, investors, lawyers, employees of funding agencies such as the National Institute for Health (NIH) and the California stem cell agency, the US Food and Drug Administration (FDA), and researchers.
Keywords:Stem Cells;Stem Cell Treatments;Adult Stem Cells;Embryonic Stem Cells;Ips Cells;Stem Cell Tourism;Aging;Cancer;Medicine;Regenerative Medicine;Anti-AgingKey Features:Novel insider' guide to stem cells giving people an exciting look into the world of stem cells and stem cell researchTackles practical issues related to stem cell treatments including cosmetics and sports medicine, areas of intense interest to the publicWritten by a stem cell scientist and cancer survivor who can see health-related issues from both perspectives as patient and professorReviews:
“This is an opinionated but extremely knowledgeable introduction to the potentials and pitfalls of research in and applications of stem cells. The science is current, accessible, and well presented, but the best aspect of the book is its focus on ethical considerations associated with stem cell research. This is a fascinating book on important scientific, medical and consumer issues.”CHOICE
This thoroughly revised version includes chapters on general physiology as well as cardiovascular, respiratory, renal, gastrointestinal, endocrine, central nervous system, and integrative physiology. It contains clinical notes, chapter outlines with page numbers, 2-color figures throughout, and new chapters on Exercise, Diabetic Ketoacidosis, and Maternal Adaptations in Pregnancy.
Among the contributors to this indispensible textbook are leading physiologists Leonard R. Johnson, Stanley G. Schultz, H. Maurice Goodman, John H. Byrne, Norman W. Weisbrodt, James M. Downey, D. Neil Granger, Frank L. Powell, Jr., James A. Schafer, and Dianna A. Johnson.
This text is recommended for medical, graduate, and advanced undergraduate students studying physiology, physicians, and clinical specialists as well as anyone interested in basic human physiology.* Includes clinical notes
* "Key Points" summarize most important information
* Contains chapter outlines with page numbers
* 2-color figures throughout
* New chapters on Exercise, Diabetic Ketoacidosis, and Maternal Adaptations in Pregnancy
For decades, scientists have been using “HeLa” cells in biological research, from developing the polio vaccine and studying the nature of cancer to observing how human biology behaves in outer space. This famous cell line began as a sample taken from a poor African American mother of five named Henrietta Lacks.
A cancer patient, Henrietta Lacks went through medical testing but never gave consent for the use of her cells. She died of cervical cancer in 1951, without ever knowing that the samples were intended for extensive medical research.
This summary of the #1 New York Times bestseller by Rebecca Skloot tells Henrietta’s story and reveals what happened when her family found out that her cells were being bought and sold in labs around the world.
With historical context, character profiles, a timeline of key events, and other features, this summary and analysis of The Immortal Life of Henrietta Lacks is intended to complement your reading experience and bring you closer to a great work of nonfiction.
Contributions come from leading voices in cell biology, who are defining the future of their field, including: - Tom Misteli, National Cancer Institute - Galit Lahav, Harvard Medical School - Scott D. Emr, Cornell University - David G. Drubin, University of California, Berkeley - Tom Rapoport, Harvard Medical School - Anthony A. Hyman, Max Planck Institute of Molecular and Cell Biology, Dresden
This publication is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals.Provides timely, comprehensive coverage across a broad range of cell biological topicsOffers foundational knowledge and expert insights to students and others new to the fieldFeatures reviews from leaders in cell biology research and discussion of future directions for the fieldIncludes articles originally published in Cell, Current Biology, Developmental Cell, and Trends in Cell Biology
In this book, more than 50 worldwide invasion scientists cover our current understanding of biological invasions, its impacts, patterns and mechanisms in both aquatic and terrestrial systems.
The book maintains a concise focus on eukaryotic cell biology as it relates to human and animal disease, all within a manageable 300-page format. This is accomplished by explaining general cell biology principles in the context of organ systems and disease.
This updated version contains 60% new material and all new clinical cases. New topics include apoptosis and cell death from a neural perspective; signal transduction as it relates to normal and abnormal heart function; and cell cycle and cell division related to cancer biology.60% New Material!New Topics include: Apoptosis and cell dealth from a neural perspectiveSignal transduction as it relates to normal and abnormal heart functionCell cycle and cell division related to cancer biologyAll new clinical cases Serves as a prep guide to the National Medical Board Exam with sample board-style questions (using Exam Master(R) technology): www.exammaster.com Focuses on eukaryotic cell biology as it related to human disease, thus making the subject more accessible to pre-med and pre-health students
This eagerly awaited edition reviews the increasing diversity of the applications of cell culture and the proliferation of specialized techniques, and provides an introduction to new subtopics in mini-reviews. New features also include a new chapter on cell line authentication with a review of the major issues and appropriate protocols including DNA profiling and barcoding, as well as some new specialized protocols. Because of the continuing expansion of cell culture, and to keep the bulk of the book to a reasonable size, some specialized protocols are presented as supplementary material online.Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, Seventh Edition provides the most accessible and comprehensive introduction available to the culture and experimental manipulation of animal cells. This text is an indispensable resource for those in or entering the field, including academic research scientists, clinical and biopharmaceutical researchers, undergraduate and graduate students, cell and molecular biology and genetics lab managers, trainees and technicians.
Donna Dickenson - Winner of the International Spinoza Lens Award
Should we do what ever science lets us do?Bioethics: All That Matters, new developments in biotechnology like genetics, stem cell research and artificial reproduction arouse both our greatest hopes and our greatest fears. Many people invest the new biotechnology with all the aspirations and faith once accorded to religious salvation. But does everyone benefit equally from scientific progress? Commercialised modern biomedicine runs the risk of exploiting vulnerable groups, from Indian 'surrogate' mothers to professional guinea pigs in drug research.
Professor Dickenson argues that although we've entered new scientific territory, there's no need to jettison our existing moral sense. By discussing a range of real-life cases, she equips readers to make up their own minds on these important and controversial questions. Good science and good ethics needn't be contradictory.
This accessible and concise book will appeal to both students and general readers, giving a fascinating introduction to a wide range of perspectives on Bioethics.
All That Matters books:
All books in the All That Matters series are written by world experts in their subject field. These experts work to distil a topic and get right to its heart, making the book accessible for both students and general readers. Each compelling book contains new and interesting perspectives and tells stories that matter.
All That Matters - Interesting introductions to important issues
Books on the following subjects are available from the All That Matters series: Muhammad, God, Water, Political Philosophy, Sustainability, Philosophy, Intelligence, Love, Russian Revolution, War, and Creativity.To find out more visit: www.allthatmattersbooks.com
Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and technologies, despite these challenges. Chapters consider stem cell toxicity by environmental agents, pharmaceutical drug candidates, and marketed therapeutic medicines with adverse side effects. New insights to cellular, molecular, biochemical, and chemical mechanisms of human tissue stem cell toxicity are brought together. Experimental and theoretical treatments are of specific topics, including approaches to monitoring TSC function, newly discovered TSC types and TSC toxicity resistance mechanisms, are covered by expert authors.
This book informs and champions the continued development of innovative technologies to predict the TSC toxicity of compounds before their use, whether in patients or the environment, by addressing emerging new cell-based approaches and concepts for technical innovation. This publication will be a useful reference for postgraduate students and researchers working in toxicology, pharmaceutical science, tissue cell biology and stem cell biology.
This forward looking cancer biology book appeals to a wide ranging audience. Introductory chapters that provide the molecular, cellular, and genetic information needed to comprehend the material of the subsequent chapters bring unprepared students up to speed for the rest of the book and serve as a useful refresher for those with previous biology background. The second set of chapters focuses on the main cancers in terms of risk factors, diagnostic and treatment methods and relevant current research. The final section encompasses the immune system’s role in the prevention and development of cancer and the impact that the Human Genome Project will have on future approaches to cancer care.
While best suited to non-majors cancer biology courses, the depth provided satisfies courses that combine both majors and non-majors. Also, and deliberately, the authors have incorporated relevant information on diagnosis and treatment options that lend appeal to the lay reader.
Making PCR explores the culture of biotechnology as it emerged at Certus Corporation during the 1980s and focuses on its distinctive configuration of scientific, technical, social, economic, political, and legal elements, each of which had its own separate trajectory over the preceding decade. The book contains interviews with the remarkable cast of characters who made PCR, including Kary Mullin, the maverick who received the Nobel prize for "discovering" it, as well as the team of young scientists and the company's business leaders.
This book shows how a contingently assembled practice emerged, composed of distinctive subjects, the site where they worked, and the object they invented.
"Paul Rabinow paints a . . . picture of the process of discovery in Making PCR: A Story of Biotechnology [and] teases out every possible detail. . . . Makes for an intriguing read that raises many questions about our understanding of the twisting process of discovery itself."—David Bradley, New Scientist
"Rabinow's book belongs to a burgeoning genre: ethnographic studies of what scientists actually do in the lab. . . . A bold move."—Daniel Zalewski, Lingua Franca
"[Making PCR is] exotic territory, biomedical research, explored. . . . Rabinow describes a dance: the immigration and repatriation of scientists to and from the academic and business worlds."—Nancy Maull, New York Times Book Review
With The Cell: A Visual Tour of the Building Block of Life, Jack Challoner treats readers to a visually stunning tour of these remarkable molecular machines. Most of the living things we’re familiar with—the plants in our gardens, the animals we eat—are composed of billions or trillions of cells. Most multicellular organisms consist of many different types of cells, each highly specialized to play a particular role—from building bones or producing the pigment in flower petals to fighting disease or sensing environmental cues. But the great majority of living things on our planet exist as single cell. These cellular singletons are every bit as successful and diverse as multicellular organisms, and our very existence relies on them.
The book is an authoritative yet accessible account of what goes on inside every living cell—from building proteins and producing energy to making identical copies of themselves—and the importance of these chemical reactions both on the familiar everyday scale and on the global scale. Along the way, Challoner sheds light on many of the most intriguing questions guiding current scientific research: What special properties make stem cells so promising in the treatment of injury and disease? How and when did single-celled organisms first come together to form multicellular ones? And how might scientists soon be prepared to build on the basic principles of cell biology to build similar living cells from scratch.
First student textbook of phylogenetic reconstruction which uses the tree as a central metaphor of evolution.
Chapter summaries and annotated suggestions for further reading.
Worked examples facilitate understanding of some of the more complex issues.
Emphasis on clarity and accessibility.
Contributions come from leading voices in the field, including: - Daniel A. Haber, Director of Massachusetts General Hospital Cancer Center and Professor at Harvard Medical School - Tony Kouzarides, Professor at the University of Cambridge, Deputy Director of the Wellcome Trust/Cancer Research UK Gurdon Institute, and a founder of the cancer drug discovery company Chroma Therapeutics - Charles L. Sawyers, Chair of the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, President of the American Association for Cancer Research, member of the presidentially appointed National Cancer Advisory Board, and recipient of the 2013 Breakthrough Prize in Life Sciences
Cell Press Reviews: Cancer Therapeutics is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals.Provides timely, comprehensive articles on a wide range of topics in cancer therapeuticsOffers insight from experts on genetic, molecular, and cellular aspects of cancer therapyFeatures reviews on basic science advances translated into drug discovery and therapeutic approachesIncludes articles originally published in Cell, Cancer Cell, Trends in Genetics, Trends in Molecular Medicine, and Trends in Pharmacological Sciences
In addition to a number of informative changes to the text throughout the book, the final four chapters have been significantly updated and extended to reflect the striking advances made in recent years in the applications of gene cloning and DNA analysis in biotechnology.
Gene Cloning and DNA Analysis remains an essential introductory text to a wide range of biological sciences students; including genetics and genomics, molecular biology, biochemistry, immunology and applied biology. It is also a perfect introductory text for any professional needing to learn the basics of the subject. All libraries in universities where medical, life and biological sciences are studied and taught should have copies available on their shelves.
"… the book content is elegantly illustrated and well organized in clear-cut chapters and subsections… there is a Further Reading section after each chapter that contains several key references… What is extremely useful, almost every reference is furnished with the short but distinct author's remark."
–Journal of Heredity, 2007 (on the previous edition)
While the main focus is on economics, this guide is written in non-technical language for an audience of health policy decision makers or students of health policy, making it an invaluable contribution to the current debate surrounding the control of rising healthcare-related costs in the developed world.
additives, and their potential as source of high-added value compounds is well known.
But, in contrast to the large number of genetically modified bacteria, yeast and even
higher plants, only a few species of microalgae have been genetically transformed
with efficiency. Initial difficulties in the expression of foreign genes in microalgae
have been progressively overcome, and powerful molecular tools for their genetic
engineering are now on hand. A considerable collection of promoters and selectable
marker genes and an increasing number of genomic or cDNA sequences have become
available in recent years. More work is needed to transform new species of
microalgae, specially those that have commercial value, so that it would be possible
to increase the productivity of traditional compounds or synthesize novel ones. Silencing
transgenes remains as an important limitation for stable expression of foreign
genes. This problem is not unique to microalgae since it has also been observed
in plants, animals and fungi. A better understanding of the mechanisms that control
the regulation of gene expression in eukaryotes is therefore needed.
In this book a group of outstanding researchers working on different areas of
microalgae biotechnology offer a global vision of the genetic manipulation of
microalgae and their applications.
Revolutionary new science is providing cures that were considered science fiction just a few years ago—and not with pills, surgery, or radiation, but with human cells.
Promising treatments now in extensive clinical trials could have dramatic impacts on cancer, autoimmune diseases, organ replacement, heart disease, and even aging itself. The key to these breakthroughs is the use of living cells as medicine instead of traditional drugs.
Discover the advances that are alleviating the effects of strokes, Alzheimer’s disease, and even allergies. Cells Are the New Cure takes you into the world of regenerative medicine, which enables doctors to repair injured and aging tissues and even create artificial body parts and organs in the lab. Cellular medicine experts Robin L. Smith, MD, and Max Gomez, PhD, outline the new technologies that make it possible to harness the immune system to fight cancer and reverse autoimmune diseases like multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. CRISPR, a new technology for targeted gene editing, promises to eradicate genetic diseases, allowing us to live longer lives—possibly even beyond age 100 in good health.
Cells Are the New Cure takes you on a tour of the most exciting and cutting-edge developments in medicine. The content inside these pages could save your life or the life of someone you love.
Regenerating the Heart: Stem Cells and the Cardiovascular System organizes the field into a digestible body of knowledge. Its four sections cover mechanical regeneration, electrical regeneration, cardiac tissues and in vivo stem cell therapies. An array of talented researchers share the fruits of their labors, with chapters covering such crucial issues as the cardiogenic potential of varying stem cell types, the ways in which they might be used to tackle arrhythmias, their possible application to biological replacements for cardiac tissues such as valves, and the varying approaches used in the in vivo evaluation of stem cell therapies, including methods of delivering stem cells to the myocardium.
This comprehensive survey of an area of research with such exciting potential is an invaluable resource both for veteran stem cell researchers who need to monitor fresh developments, and for newly minted investigators seeking inspirational examples.
The book will help the non-scientist understand the biology, research regulations and funding; and simultaneously it will help the scientist better comprehend the full spectrum of ethical, religious, and policy debates.
Flow Cytometry: First Principles, Second Edition explains the basic principles of flow cytometry, surveying its primary scientific and clinical applications and highlighting state-of-the-art techniques at the frontiers of research. This edition contains extensive revisions of all chapters, including new discussions on fluorochrome and laser options for multicolor analysis, an additionalsection on apoptosis in the chapter on DNA, and new chapters onintracellular protein staining and cell sorting, including high-speed sorting and alternative sorting methods, as well as traditional technology. This essential resource:Assumes no prior knowledge of flow cytometry Progresses with an informal, engaging lecture style from simpleto more complex concepts Offers a clear introduction to new vocabulary, principles of instrumentation, and strategies for data analysis Emphasizes the theory relevant to all flow cytometry, with examples from a variety of clinical and scientific fields
Flow Cytometry: First Principles, Second Edition provides scientists, clinicians, technologists, and students with the knowledge necessary for beginning the practice of flow cytometry and for understanding related literature.
The editors have built Phagocytosis: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Vaccines in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Phagocytosis: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility.