Annual Reports in Medicinal Chemistry

Annual Reports in Medicinal Chemistry

This concise guide to cannabis delves into pot culture and history, from Herodotus To The hippies and beyond. it also covers the essentials of using, cultivating, and cooking with weed; identifying pot varieties; and understanding legal and health issues. Handy and To The point, The Little Black Book of Marijuana gives you "the dope" on pot, from possible side effects and risks to medical uses and their efficacy. Learn about cannabis history And The issues around its legalization. Includes full-color photos of marijuana varieties.

THE CONSUMER’S GUIDE TO PILLS—COMPLETELY REVISED 14th EDITION FOR 2010 WITH MORE THAN 20 IMPORTANT NEW DRUGS AND DOZENS OF NEW BRAND NAMES
 
For more than three decades, millions of consumers have trusted The Pill Book to provide official, FDA-approved information on more than 1,800 of the most commonly prescribed drugs in the United States with guidelines from leading pharmacists. Each drug is profiled in a concise, readable, easy-to-understand entry, making The Pill Book the perfect reference when you have questions about the medications your doctor prescribes. Inside you’ll discover
 
• generic and brand-name listings that can help you save money
• What each drug is for, and how it works
• usual dosages, and what to do if a dose is skipped
• side effects and possible adverse reactions, highlighted for quick reference
• interactions with other drugs and food
• overdose and addiction potential
• alcohol-free and sugar-free medications
• the most popular self-injected medications and their safe handling
• information for seniors, pregnant and breast-feeding women, children, and others with special needs
• cautions and warnings, and when to call your doctor
• 32 pages of actual-size color photographs of prescription pills*
 
No home should be without this book!


*Not all ereading devices will show the images in color and at the exact size.

For more than two decades, millions of consumers have trusted The Pill Book to provide official, FDA-approved drug information plus guidelines from leading pharmacists. Each drug is profiled in a concise, readable, and easy-to-understand entry, making The Pill Book the perfect reference when you have questions about the medications your doctor prescribes.

The most up-to-date information about the more than 1,800 most commonly prescribed drugs in the United States:

• Generic and brand-name listings that can help you save money
• What the drug is for, and how it works
• Usual dosages, and what to do if a dose is skipped
• Side effects and possible adverse reactions, highlighted for quick reference
• Interactions with other drugs and food
• Overdose and addiction potential
• Alcohol-free and sugar-free medications
• The most popular self-injected medications and their safe handling
• Information for seniors, pregnant and breast-feeding women, children, and others with special needs
• Cautions and warnings, and when to call your doctor
• 32 pages of actual-size color photographs of prescription pills


From the Trade Paperback edition.

★★★★★LEARNING STARTS WITH VIEWING THE WORLD DIFFERENTLY.★★★★★

Knowledge flow — A mobile learning platform provides Apps and Books.

Knowledge flow provides learning book of Pharmacology. This book is for all medical and science students, graduates and professionals across the world. Pharmacology is the science of drug action on biological systems. This Pharmacology book provides drugs action, pharmaceutical uses and side effects of drugs.

Contents:

1. Introduction to Pharmacology

2. Pharmacokinetics

3. Pharmacodynamics

4. Psychopharmacology

5. Drugs affecting on Nervous system

6. Drugs affecting on Central nervous system

7. Drugs affecting on Cardiovascular system

8. Classification of Endocrine system

9. Drugs affecting on Respiratory system

 10. Drugs affecting on Gastro intestinal Tract

 11. Drugs affecting on Erectile dysfunction

12. Drugs affecting on Erythrocytic

To find more education books, visit here http://knowledgeflow.in/books.

DMSO A True Wonder Drug

DMSO is a natural chemical compound derived from trees as a by-product from paper manufacturing. DMSO has been called a new medical principle and a true wonder drug. It has proven effective, either by itself or in combination with other products in the treatment of nearly every ailment known.

There has been much controversy about DMSO over the last 50 years. It is one of the most studied medical products ever. Thousands of scientific articles have been written about DMSO. When used properly it is one of the safest products know. It is also very cheap to produce.

This book provides the documentation needed to show that DMSO is probably the most important product ever for the relief of human suffering.

******

Archie is quite clearly a leading authorithy on DMSO. He has extensive knowledge and experience regarding the clinical benefits of DMSO treatment. For decades, Archie has studied and worked with DMSO. He understands the safety, utility and efficaciousness of DMSO. I highly recommend this book for anyone interested in health, especially for those who want to learn more about non toxic medical therapies. For individuals with certain health ailments, DMSO could prove quite benefical. -Daniel Junck, MD

Opioids such as morphine, codeine, and oxycodone are extracts or analogs isolated from a single source: the opium poppy. For a long time, it was believed to be nature’s only source of opioids. But it now appears that biological diversity has evolved an alternative source of opioid compounds—those derived from the plant Mitragyna speciosa. This plant, known as Kratom in Thailand or Biak-Biak in Malaysia, has long been used locally as treatment for pain, fever reduction, diarrhea, and even depression.

Kratom and Other Mitragynines: The Chemistry and Pharmacology of Opioids from a Non-Opium Source

presents an introduction to the chemical and biological properties of alkaloids isolated from M. speciosa as well as their synthetic analogs. The book covers various topics including phytochemistry, medicinal chemistry, and pharmacology. Current research, analgesic effects, and addiction potential are also discussed. As the first extensive text on the basic science and clinical use of Kratom, the book provides readers with a concise yet comprehensive introduction to nature’s "other opioid."

Buprenorphine, often better known by the brand name Suboxone®, is currently the preferred drug for helping people recover from opiate addiction. But how is the drug best used? Is it something that should be used on a short-term or long-term basis? Can patients really taper off the drug, and if so, how do they go about it with a minimal amount of problems? And what other things should Suboxone patients be doing to ensure they have a positive experience with the drug? In this compelling book, Sebastian Enfield lays it all on the line, and explains how doctors and patients should approach buprenorphine therapy to maximize the chances of successful treatment and recovery.

Author Sebastian Enfield had it all. A loving family, an up-and-coming career at a Fortune 500 company, good friends and an active social life. He was living the proverbial American dream. Until, that is, his life was sidetracked when he became addicted to painkillers. It all started with far-too-easy online purchases of narcotic pills, and eventually Sebastian “graduated” to heroin. As with most addicts, as his opiate habit developed his life began to unravel. Family, friends and career became less and less important. Maintaining his expensive addiction became the most important priority each day. But when a winter blizzard came one December and “his guy” stopped returning his phone calls, Sebastian knew another kind of storm was heading his way. Withdrawal. He suffered in bed for a few days before his dealer finally returned his calls and delivered the goods. But this was the final turning point. After all he had gone through, Sebastian knew things couldn’t continue like this. So he made arrangements to visit a Suboxone-prescribing doctor, and very shortly thereafter, he was finally on the long road to recovery.

But while being treated with Suboxone, Sebastian had some anxieties and a lot of questions. “How long should I really be on this stuff? Should I try to taper off or not? And if so, how do you do it so as to minimize any discomfort? What other things should I be doing to aid in my recovery?” He looked to the Internet for answers, but what he found was a lot of contradictory information, posts from people claiming that “this stuff is even worse than what I was on before!”, and even disagreement among doctors and other health professionals with regard to Suboxone treatment protocols. Sebastian suspected that if he found all this confusing, there were probably many others in the same boat.

And so, he set out to investigate all of this, and to write a book that explained his findings in clear and simple terms. Sebastian spoke with various doctors, Suboxone patients and therapists, and synthesized their views and opinions, along with his own experiences, into a book of tips and suggestions that would help doctors and patients best approach buprenorphine treatment.

Sebastian begins with his own compelling story, where he details the life journey that ultimately led to drug addiction. He then presents several suggestions and tips that cover a wide range of questions he knew Suboxone patients had. The book covers a variety of topics, such as how to best select a doctor, how to approach counseling (and whether you really need counseling), how to taper off the medication with minimal discomfort (and whether you even should taper off the medication), resources that may help with paying for treatment, and a variety of “lifestyle hacks” Sebastian found to be useful while being treated. Sebastian lays all of this out clearly, and provides a positive and motivating read that will help patients understand that treatment with buprenorphine need not be a scary and uncertain thing. On the contrary, it can be a constructive part of recovery from opiate addiction. As he put it, “This is the book I wish I had when I began buprenorphine treatment.”

Father Romano Zago, a Franciscan Friar and scholar, wrote the book Cancer Can Be Cured to reveal to the world an all natural Brazilian Recipe that contains the juice made from the whole leaf plant of Aloe Arborescens and honey that has been shown to rapidly restore the body's health so it heals itself of all types of cancer. The book tells how it was while administering to the poor in the shantytown of Rio Grande dol Sul , Brazil that he and the provincial Father Arno Reckziegel, witnessed the healing of simple people of cancer who used this recipe. Later, when he had assignments in Israel and Italy where this aloe species grows naturally he continued to see great success in the chronically ill being cured when he recommended they use this recipe. This inspired for him to spend the next 20 years in researching the science behind this aloe species and the publication of that research in this book along with his numerous first hand anecdotes of cancer healing by those using the Brazilian juice recipe. Chapters include information on how to prepare the recipe using the three ingredients of whole leaf Aloe arborescens juice, honey and a small amount of distillate (1%); how to take the preparation; questions and answers on everything from how to pick the aloe leaves, why each of the three ingredients is important in the recipe, the types of cancer that have been cured using the recipe, other diseases and health problems the recipe has shown to be beneficial in helping the human body solve; the internationalization of the recipe on five continents; anecdotal stories of some body healings; the composition of Aloe; and Aloe and Aids. There has been much publicized scientific research and literature on the synergistic benefits of the 300 phytotherapeutic biochemical and nutrient constituents of Aloe vera to aid the body's defenses to enhance the immune system and protect against diseases. However, this is the first book to reveal the little known potency

The best and easiest way to learn essential information about the top 300 drugs Includes recently approved hepatitis C vaccines

Every card includes:

Generic and common name Class Dosage Forms Approved Dose and Indications Off-Label Use Contraindications Adverse Reactions Drug Interactions Monitoring Parameters Medication Safety Issues and Black Box Warnings Clinical pearls that help guide patient care Strong focus on patient safety

This edition is enhanced by 11 new cards, key adult and pediatric immunization vaccines, and MP3 audio download with detailed discussion of each drug.

PHARMACY TECHNICIAN CERTIFICATION EXAM REVIEW, 3E is a comprehensive, all inclusive study tool to help prepare your students to become certified pharmacy technicians on a national level. This book mirrors content covered on the Pharmacy Technician Certification Exam (PTCE) and provides both exam content review and practice opportunities in a variety of formats. Ideal for review courses and for individual study, this book is a must-have tool for anyone preparing to take the PTCB and ExCPT exams. Sections are structured to help your students focus on critical topic areas outlined by the Pharmacy Technician Certification Board; including 14 chapters specifically on mathematics with examples and end-of-chapter review questions. This new edition also includes greatly expanded chapters on pharmacology, updated end-of-chapter practice questions, two cumulative tests at the end of the book, and solutions to all chapter review questions and practice exams. For even more practice, the back-of-book CD offers 600 additional review questions to create timed exams that simulate the actual PTCE!
Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Revised and significantly expanded, the new edition of this handbook provides full information on the use of essential oils in the field of contemporary aromatherapy, based on the research evidence behind their therapeutic applications. The author provides the historical and cultural context for our understanding of aromatherapy, with an overview of its relationships with Greek, Chinese and Ayurvedic medicine. She gives a detailed account of how essential oils are created, how and where aromatherapy is used, the underlying pharmacology, and the current research. The characteristics of over 100 essential oils, absolutes and resinoids are provided in detail, including botanical and chemical information, usage and combinations. This will be an indispensable text for all students and practitioners of aromatherapy and related disciplines, as well as anyone interested in the use of essential oils for health and well-being.

We like to imagine that medicine is based on evidence and the results of fair testing and clinical trials. In reality, those tests and trials are often profoundly flawed. We like to imagine that doctors who write prescriptions for everything from antidepressants to cancer drugs to heart medication are familiar with the research literature about a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by the pharmaceutical industry. We like to imagine that regulators have some code of ethics and let only effective drugs onto the market, when in reality they approve useless drugs, with data on side effects casually withheld from doctors and patients.
All these problems have been shielded from public scrutiny because they're too complex to capture in a sound bite. But Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct in the medical industry affects us on a global scale.
With Goldacre's characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for regulation. This is the pharmaceutical industry as it has never been seen before.

Completely revised and updated to reflect the significant advances in pharmaceutical production and regulatory expectations, this third edition of Validation of Pharmaceutical Processes examines and blueprints every step of the validation process needed to remain compliant and competitive. The many chapters added to the prior compilation examine validation and six sigma system design; the preparation of aseptic and non-aseptic pharmaceutical products; active pharmaceutical ingredient and biotechnology processes, computerized systems; qualification and cleaning of equipment; analytical methods, calibration and certification. As the industry's leading source for validation of sterile pharmaceutical processes for more than 10 years, this greatly expanded is a comprehensive analysis of all of the fundamental elements of this arena with practical solutions for every pharmaceutical and bio-pharmaceutical production process.

Presenting theoretical knowledge and applied practical considerations, this title
provides an in-depth discussion of recent advances in sterilization
identifies obstacles that may be encountered at any stage of the validation program, and suggests the newest and most advanced solutions
explores distinctive and specific process steps, and identifies critical process control points to reach acceptable results
blends the use of theoretical knowledge with recent technological advancements to achieve applied practical solutions

In recent years, the field of pharmaceutical microbiology has experienced numerous technological advances, accompanied by the publication of new and harmonized compendial methods. It is therefore imperative for those who are responsible for monitoring the microbial quality of pharmaceutical/biopharmaceutical products to keep abreast of the latest changes. Microbial Limit and Bioburden Tests: Validation Approaches and Global Requirements guides readers through the various microbiological methods listed in the compendia with easy-to-follow diagrams and approaches to validations of such test methodologies.

 

Includes New and Updated Material

Now in its second edition, this work is the culmination of research and discussions with technical experts, as well as USP and FDA representatives on various topics of interest to the pharmaceutical microbiologist and those responsible for the microbial quality of products, materials, equipment, and manufacturing facilities. New in this edition is an entire chapter dedicated to the topic of biofilms and their impact on pharmaceutical and biopharmaceutical operations. The subject of rapid methods in microbiology has been expanded and includes a discussion on the validation of alternative microbiological methods and a case study on microbial identification in support of a product contamination investigation.

Substantially updated and revised, this book assists readers in understanding the fundamental issues associated with pharmaceutical microbiology and provides them with tools to create effective microbial contamination control and microbial testing programs for the areas under their responsibility.

This book highlights the challenges facing quality assurance/quality control (QA/QC) in today's biopharmaceutical environment and presents the strategic importance and value generated by QA/QC for their involvement in control of manufacturing. It will put into perspective the need for a graded approach to QA/QC from early clinical trials through market approval. Since the first edition published in 2004, there have been more than 50 new regulatory guidances released by the Food and Drug Administration (FDA), European Medicines Agency (EMA) and ICH that affect the CMC regulatory compliance of biopharmaceuticals; also the application of biosimilars has been developed in Europe and is under development in the USA. The revised update will be broadened to include not only biopharmaceuticals (biotech drugs) but also other biologics (vaccines, cell therapy, plasma-derived proteins, etc.)

Select the most appropriate drug in any clinical situation--quickly and easily

Developed for use at the point of care, Pharmacotherapy Bedside Guide helps you decide which pharmacotherapy to employ in specific clinical situations. Comprised exclusively of quick-hit tables and algorithms, this carryanywhere companion tells you what treatment the evidence suggests for each illness or disorder. It also details essential drug information, such as benefits, risks, adverse reactions, dosage, interactions with other drugs, and responses. Conveniently organized by specialty and disorder rather than drug, Pharmacotherapy Bedside Guide will prove invaluable when treating patients.

Featuring the contributions of leading faculty, this new edition provides a succinct overview of the most important aspects of pharmacology necessary for a basic understanding of the subject. It reviews the concepts, clinical applications and side effects of pharmacology, placing an emphasis on practical applications of the material, whenever possible. More than 480 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade names—as well as USMLE-style self-assessment questions with answers and rationales—reinforce your mastery of the information. A consistent style of writing—and more focused, concise content—provide for better learning of the essentials. Online access to Student Consult—where you’ll find 15 pharmacology animations...150 USMLE-style questions...and more—further enhances your study and prepares you for exams.Includes online access to Student Consult where you’ll find USMLE-style questions, animations showing the actions of various important toxins, and much more. Focuses on the essential aspects of pharmacology for a solid foundation of knowledge in the subject. Includes more than 480 full-color illustrations that explain key pharmacologic processes. Provides between 4 and 6 USMLE-style self-assessment questions at the end of each chapter—with answers and full explanations in the appendix—that help you prepare for exams and master the material. Uses a templated format that promotes more effective and efficient learning. Presents color-coded boxes in each chapter that emphasize key points. Features a clinical emphasis throughout on both the basic science of pharmacology and its clinical relevance. Includes new Gold Standard content on Student Consult with 200 Professional Drug Monographs for additional information on generic and brand names, mechanism of action, pharmacokinetics, indications and dosage, drug interactions, patient education and much more!Features a more consistent style of writing—as well as focused, concise content—for enhanced learning of the essentials. Presents chapters in a re-arranged order for a more logical approach to learning. Includes additional biochemistry and physiology information in the introduction for each section for greater understanding.

With global harmonization of regulatory requirements and quality standards and national and global business consolidations ongoing at a fast pace, pharmaceutical manufacturers, suppliers, contractors, and distributors are impacted by continual change. Offering a wide assortment of policy and guidance document references and interpretations, this Sixth Edition is significantly expanded to reflect the increase of information and changing practices in CGMP regulation and pharmaceutical manufacturing and control practices worldwide. An essential companion for every pharmaceutical professional, this guide is updated and expanded by a team of industry experts, each member with extensive experience in industry or academic settings.

Many of the nearly 70 million Americans with hypertension (high blood pressure) would like to bring it under control through lifestyle changes such as losing weight, cutting back on salt, exercising, or reducing stress. But, like it or not, most will require medication to get their blood pressure where it needs to be. The good news is that we have many excellent blood pressure medications which, when prescribed wisely, can control hypertension in almost everyone. The bad news is that, despite good intentions, doctors are placing millions of people who have hypertension on medications, drug combinations, or doses that are wrong for them, with staggering consequences that include uncontrolled hypertension, higher risk for stroke and heart attack, avoidable side effects, and billions of wasted health care dollars.
Here, Dr. Mann, a nationally recognized hypertension specialist, identifies the drugs most likely to have side effects, and those that can be used in their place. He describes the shortcomings of some of the new drugs, while also introducing readers to some excellent old drugs that are woefully underused as a result of the publicity blitz surrounding the new, expensive ones. He emphasizes the importance of matching the medication and dosage to the individual who will be taking them, and presents the overlooked clues that can tell us who should be on which drug (even an excellent drug can be the wrong one if it is given to the wrong person or in the wrong dose). Hypertension and You is directed at the more than 50 million Americans (including a majority of people over the age of 60) who are taking blood pressure medication. Many patients suspect they might be on the wrong medication, but don’t know enough to be sure. This book shows how medications can be prescribed more wisely to achieve better results and gives patients the knowledge they need to capably discuss their medications with their health care providers.
Hypertension and You provides many ideas and approaches that will be new to readers, and also to many physicians, and which no other book offers. It’s the first book to make the case that something is terribly wrong with how doctors are prescribing drugs for this condition. It provides readers with better knowledge of the available medications, empowering them to work with their physician to get onto the medications that are right for them.

"Even though depression has periodically made me feel that my life was not worth living, has created havoc in my family, and sometimes made the work of teaching and writing seem impossible," writes David Karp, "by some standards, I have been fortunate." Indeed, depression can be devastating, leading to family breakups, loss of employment, even suicide. And it is a national problem, with some ten to fifteen million Americans suffering from it, and the number is growing. In Speaking of Sadness, Karp captures the human face of this widespread affliction, as he illuminates his experience and that of others in a candid, searching work. Combining a scholar's care and thoroughness with searing personal insight, Karp brings the private experience of depression into sharp relief, drawing on a remarkable series of intimate interviews with fifty depressed men and women. By turns poignant, disturbing, mordantly funny, and wise, Karp's interviews cause us to marvel at the courage of depressed people in dealing with extraordinary and debilitating pain. We hear what depression feels like, what it means to receive an "official" clinical diagnosis, and what depressed persons think of the battalion of mental health experts--doctors, nurses, social workers, sociologists, psychologists, and therapists--employed to help them. We learn the personal significance that patients attach to beginning a prescribed daily drug regimen, and their ongoing struggle to make sense of biochemical explanations and metaphors of depression as a disease. Ranging in age from their early twenties to their mid-sixties, the people Karp profiles reflect on their working lives and career aspirations, and confide strategies for overcoming paralyzing episodes of hopelessness. They reveal how depression affects their intimate relationships, and, in a separate chapter, spouses, children, parents, and friends provide their own often-overlooked point of view. Throughout, Karp probes the myriad ways society contributes to widespread alienation and emotional exhaustion. Speaking of Sadness is an important book that pierces through the terrifying isolation of depression to uncover the connections linking the depressed as they undertake their personal journeys through this very private hell. It will bring new understanding to professionals seeking to see the world as their clients do, and provide vivid insights and renewed empathy to anyone who cares for someone living with the cruel unpredictability of depression.

238 Q&A cards sharpen your therapeutic decision-making skills

"These cards offer concise yet detailed case studies for students to review current pharmacotherapeutic options for many of the commonly encountered disease states....Students might find these cards to be a very helpful in addition to their therapeutics courses to help them retain knowledge through the use of real-life clinical scenarios. 3 Stars."--Doody's Review Service

These 238 Q&A cards provide a complete review of pharmacotherapeutic concepts for the major disease states most often encountered in practice

Emphasizes evidence-based therapeutic decision making and drug therapy monitoring Each card features a case and therapeutic question Key facts are included for the drug or drug class that correctly answers the question Case Notes explain the answer and include clinical pearls about use of the drug, management of the disease, and dosing

It’s the business of saving lives.
 
Miracle Medicines goes behind the scenes of the pharmaceutical industry and into the high-security laboratories to tell the stories of the men and women---chemists, physiologists, medical and clinical researchers, engineers---who have chosen to toil for years in the lab in order to transform scientific theories into new lifesaving medicines.
 
You’ll witness the day-to-day labors, victories and defeats of the dedicated professionals who are waging a war against the diseases that still plague mankind. From the confines of their laboratories, these pharmaceutical adventurers explore unknown territories in health and science.
 
Miracle Medicines reveals what really happens during the long and uncertain journey that each new drug and its creators must endure from theory, to research, to testing and, finally, FDA approval and delivery to the public. It’s a very human story within the context of fascinating scientific innovation.
 
Through first hand interviews you’ll also meet the patients who benefit from these manmade miracles and learn how, within their bloodstreams, an ongoing battle is raging. The drugs profiled are:Advair: GlaxoSmithKline’s revolutionary asthma medication, the first packaged as both a control and emergency drug.Gleevec: The Novartis’ chronic myeloid leukemia treatment born from decades of medical research in a field of study that was once considered hopeless.Humalog: Eli Lilly’s reinvention of insulin to control diabetes has been described as being better than natureLipitor: Pfizer’s miracle antidote for high cholesterol that was nearly lost to the pharmaceutical vaults and has since become the world’s top-selling medicine.Norvir: Abbott’s contribution to the fight against HIV that nearly erases all traces of the disease from the bloodstream and prolongs the life of patients.Remicade: Created for the treatment of Crohn’s disease, rheumatoid arthritis and other Immune Mediated Inflammatory Diseases, Johnson & Johnson’s revolutionary biomedicine was developed from technology that once was only found in science fiction.Seroquel: AstraZeneca’s treatment for both schizophrenia and bipolar mania that has given millions of psychiatrics a new lease on life.
This compelling and truth-revealing book will forever change the way you view the medicines in your medicine cabinet, and the people who create them.

Get the essential tools you need to make an accurate diagnosis with Vascular and Interventional Radiology: The Requisites! This bestselling volume delivers the conceptual, factual, and interpretive information you need for effective clinical practice in vascular and interventional radiology, as well certification and recertification review. Master core knowledge the easy and affordable way with clear, concise text enhanced by at-a-glance illustrations, boxes, and tables – all completely rewritten to bring you up to date with today’s state of the art in vascular and interventional radiology.Understand the basics with a comprehensive yet manageable review of the principles and practice of vascular and interventional radiology. Whether you’re a resident preparing for exams or a practitioner needing a quick-consult source of information, Vascular and Interventional Radiology is your guide to the field.

 Nurse prescribers are now practising within every discipline of nursing and midwifery, both in the community and the hospital setting. This much-needed book is aimed particularly at students on a non-medical prescribing (NMP) course as well as those nurses who are studying for their community practitioner non-medical prescribing qualification as part of the specialist practice programme. The book is also a useful resource for nursing students and registered nurses who administer and/or prescribe medicines. 

The authors offer a basic introduction to pharmacological concepts, embedded in specific conditions, through case studies and self-assessment questions. By utilising a case study approach, they enable the reader to link pharmacological concepts with clinical practice. 

Many of the conditions presented will be seen across all healthcare settings. In addition, the comprehensive glossary and list of abbreviations will enable students to understand some of the more technical terms used in the British National Formulary (BNF) and other prescribing sources. 

Reading this book, and carrying out the numerous self-assessment activities, will give the reader an appreciation of the value of having a sound pharmacological knowledge base in order to deliver safe practice, effective prescribing and improved patient care.

Contents include:

Introduction  

How the body affects drugs  

How drugs affect the body

Types of adverse drug reactions and interactions 

Understanding and using the British National Formulary

Adherence

Children

Stable angina

Hypertension

Heart failure

Chronic obstructive pulmonary disease 

Neurological problems

Gastrointestinal disorders

Incontinence in adults

Diabetes

Mental health problems

Eye problems

Complex health needs and polypharmacy

Palliative care

The challenges of non-medical prescribing

Elvis Presley, the Hell’s Angels, Hunter S. Thompson, Truman Capote, the Beatles, Judy Garland, Hank Williams, the Manson Family, Jack Kerouac, Johnny Cash, JFK, and Adolf Hitler. All of the above were, at one time or another, to put it bluntly, speedfreaks.

Speed-Speed-Speedfreak traces the criminal and cultural use of amphetamine and its growing use through each new and destructive cycle. The book will be printed in rounded pill capsule form, like the vaunted “black beauty” of pharmaceutical history.

Mick Farren is the former lead singer of The Deviants and the author of more than forty books.

The latest edition is the resource for any practicing OB/GYN, family physician, midwife, or pharmacist who prescribes medicinal products to or evaluates environmental or occupational exposures in women who are or may become pregnant. Based on the highly successful seven German editions of this reference, the up-to-date drug listings have been revised into a handy pocket guide color tabbed for quick access to important information. Easy to reference each drug is listed discussing the side effects, general impact on organ systems, potential toxicity, and risks before offering dosage recommendations. It is the only book of its kind to provide conclusive information on treatments for diseases during pregnancy and lactation and actions to be taken after (inadvertant) exposure to drugs suspected to be developmentaly toxic. Unlike other dosage guides, this edition is an affordable, compact compendium of knowledge on the very latest drugs and their effects on pregnant/lactating women.Provides conclusive information on the prevention of birth defects through the safe use of drugs before pregnancy, as well as during pregnancy and lactationEssential new information on herbs, vitamins, and nutrition supplements used during pregnancyStructured according to indication group, rather than alphabetically, providing a more user-friendly guide that makes it easier to compare drugsIncludes a conveniently removable 'quick reference' card of most frequently used drugs and their safety

Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone, or completely derail, important new drug development. Even much-needed reformulation of currently marketed products can be significantly affected by these challenges.

Water Insolubility is the Primary Culprit in over 40% of New Drug Development Failures

The most comprehensive resource on the topic, this second edition of Water Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe solubility properties and their impact on formulation, from theory to industrial practice. With detailed discussion on how these properties contribute to solubilization and dissolution, the text also features six brand new chapters on water-insoluble drugs, exploring regulatory aspects, pharmacokinetic behavior, early phase formulation strategies, lipid based systems for oral delivery, modified release of insoluble drugs, and scalable manufacturing aspects. The book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field.

Spanning every critical element of validation for any pharmaceutical, diagnostic, medical device or equipment, and biotech product, this Second Edition guides readers through each step in the correct execution of validating processes required for non-aseptic and aseptic pharmaceutical production. With 14 exclusive environmental performance evaluations, it features 64 new protocols on topics such as sterility assurance, media fill guidelines, and environmental control.

As the mental health reporter for the Boston Globe, Alison Bass's front-page reporting on conflicts of interest in medical research stunned readers, and her series on sexual misconduct among psychiatrists earned a Pulitzer Prize nomination. Now she turns her investigative skills to a controversial case that exposed the increased suicide rates among adolescents taking antidepressants such as Paxil, Prozac, and Zoloft.

Side Effects tells the tale of a gutsy assistant attorney general who, along with an unlikely whistle-blower at an Ivy League university, uncovered evidence of deception behind one of the most successful drug campaigns in history. Paxil was the world's bestselling antidepressant in 2002. Pediatric prescriptions soared, even though there was no proof that the drug performed any better than sugar pills in treating children and adolescents, and the real risks the drugs posed were withheld from the public. The New York State Attorney General's office brought an unprecedented lawsuit against giant manufacturer GlaxoSmithKline, the maker of Paxil, for consumer fraud. The successful suit launched a tidal wave of protest that changed the way drugs are tested, sold, and marketed in this country.

With meticulous research, Alison Bass shows us the underbelly of the pharmaceutical industry. She lays bare the unhealthy ties between the medical establishment, big pharma, and the FDA—relationships that place vulnerable children and adults at risk every day.

The essential pharmacotherapy data you need for clinical practice and board preparation – in one carry-anywhere guide

A Doody's Core Title for 2017!

Pharmacotherapy Handbook provides the critical information you need to make drug therapy decisions for more than 140 diseases and disorders commonly encountered in a clinical setting. Featuring a convenient alphabetized presentation, this handy guide utilizes text, tables, figures, and treatment algorithms to make important drug data readily accessible and easily understood.

Features:

Consistent chapter organization includes: Disease state definition Concise review of relevant pathophysiology Clinical presentation Diagnosis Goals of treatment Treatment Monitoring Six appendices, including "Allergic and Pseudoallergic Drug Reactions" and "Geriatrics" The ideal companion to Pharmacotherapy: A Pathophysiologic Approach, Ninth Edition by Joseph DiPiro, et al

"The publication of the second edition of this manual comes at an important juncture in the history of clinical research. As advances in information technology make it possible to link individuals and groups in diverse locations in jointly seeking the answers to pressing global health problems, it is critically important to remain vigilant about moral and ethical safeguards for every patient enrolled in a trial. Those who study this manual will be well aware of how to ensure patient safety along with fiscal responsibility, trial efficiency, and research integrity."
—Robert Harrington, Professor of Medicine, Director, Duke Clinical Research Institute, Durham, North Carolina, USA

The Duke Clinical Research Institute (DCRI) is one of the world's leading academic clinical research organizations; its mission is to develop and share knowledge that improves the care of patients around the world through innovative clinical research. This concise handbook provides a practical "nuts and bolts" approach to the process of conducting clinical trials, identifying methods and techniques that can be replicated at other institutions and medical practices.

Designed for investigators, research coordinators, CRO personnel, students, and others who have a desire to learn about clinical trials, this manual begins with an overview of the historical framework of clinical research, and leads the reader through a discussion of safety concerns and resulting regulations. Topics include Good Clinical Practice, informed consent, management of subject safety and data, as well as monitoring and reporting adverse events.

Updated to reflect recent regulatory and clinical developments, the manual reviews the conduct of clinical trials research in an increasingly global context. This new edition has been further expanded to include:

In-depth information on conducting clinical trials of medical devices and biologics The role and responsibilities of Institutional Review Boards, and Recent developments regarding subject privacy concerns and regulations.

Ethical documents such as the Belmont Report and the Declaration of Helsinki are reviewed in relation to all aspects of clinical research, with a discussion of how researchers should apply the principles outlined in these important documents. This graphically appealing and eminently readable manual also provides sample forms and worksheets to facilitate data management and regulatory record retention; these can be modified and adapted for use at investigative sites.

REAL-LIFE CLINICAL CASES FOR THE BASIC SCIENCES AND USMLE STEP 1

Experience with clinical cases is key to excelling on the USMLE Step 1 and shelf exams, and ultimately to providing patients with competent clinical care. Case Files: Pharmacology provides 56 true-to-life clinical cases that illustrate essential concepts in pharmacology. Each case includes an easy-to-understand discussion correlated to key basic science concepts, definitions of key terms, pharmacology pearls, and USMLE-style review questions. With Case Files, you'll learn instead of memorize.

Learn from 56 high-yield cases, each with board-style questions Master key concepts with clinical pearls Polish your approach to clinical problems and to patient care Maximize your board scores with the proven Case Files system

Great for pharmacy course review and NAPLEX preparation!

A fun, fast way to learn essential information about the most popular over-the-counter medications and herbal supplements commonly sold in U.S. pharmacies.

Essential information about 100 of the most widely used over-the-counter medications and supplements available in the United States.

Each full-color card includes an illustration, clinical pearls, and tables and text detailing:

Dosage Forms Common Self-Care Indications and Dosing Drug Characteristics Safety Issues Interactions Adverse Reactions Triage Criteria Self-Care Monitoring Parameters Key Patient Counseling Points

This spin-off from Stephen Stahl's new, completely revised, and fully updated fifth edition of the Prescriber's Guide covers the most important drugs in use today for treating depression. Now established as the indispensable formulary in psychopharmacology, easy to navigate and easy to use, the Prescriber's Guide combines evidence-based information with clinically informed guidance to support clinicians in making the most effective prescribing decisions for the good of their patients. Incorporating information on the newest indications, new formulations, new recommendations and new safety data, this edition continues to provide the essential practical support required by anyone prescribing in the field of mental health.

Effective drug administration is a crucial skill for any practitioner working in the critical care unit. This book, in providing a concise account of the fundamental principles of pharmacology and pharmacokinetics, equips the critical care physician for such a task. In addition to the principles of pharmacology and pharmacokinetics, this volume alerts the reader to factors that affect drug action such as disease, pregnancy and age, and advises on how to adjust drug dosages accordingly. The specialist therapeutics covered comprise drugs targeting the gastro-intestinal tract, sedation, non-opioid analgesia and opiates. A quick and easy reference, this volume will prove a valuable asset for both trainees and fully qualified practitioners in critical care.

In the 20 years that have passed since the publication of the first edition, both Poison Control Centers and Emergency Departments have witnessed an expansion in the number and variety of poisonings caused by toxic plants. At the same time, there is a proliferation in the diversity of plants in our gardens and homes, continually expanding the range of possible consequences from exposure to toxic plants.

This second edition of the Handbook of Poisonous and Injurious Plants is created to assist the clinician in the initial response to the needs of a child or adult exposed to a poisonous or injurious plant. It lists common plants that might lead to the development of the symptom complex and describes the mechanisms of action of the implicated toxin, additional clinical manifestations, and specific therapeutics for each presentation. It has methodically enhanced the previous edition’s botanical rigor with insights from both pharmacognosy and clinical medicine to make it a truly comprehensive source.

With its thorough references and full-color photos of hundreds of potentially toxic and injurious plants inside the home, anyone who has an interest in plants will find this book useful outside in the garden or out in the wild.

This book will fascinate botanists, horticulturists, and naturalists as well as hikers, gardeners, and all those who simply enjoy the wonders of nature and the great outdoors!

With Foreword by Lewis R. Goldfrank, MD and Introduction by Andrew Weil, MD

Better understand the complexities of pharmacology and physiology relevant to your practice with the brand-new medical reference book, Pharmacology and Physiology for Anesthesia. Drs. Hugh Hemmings and Talmage Egan provide the clinical insights you need to effectively administer anesthesia, ensuring patient safety and the most optimal outcomes.

Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.

Access comprehensive, continually updated research on the physiology of organ systems and clinical topics in the pharmacology of anesthetic drugs.

Quickly and easily reference the information you need through user-friendly tables, figures, and algorithms, all presented in lavish full color throughout.

Understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these key areas.

Because of rapid developments in the biotechnology industry—and the wide range of disciplines that contribute to its collective growth—there is a heightened need to more carefully plan and fully integrate biotech development projects. Despite the wealth of operations experience and associated literature available, no single book has yet offered a comprehensive, practical guide to fundamentals.

Filling the void, Biotechnology Operations: Principles and Practices reflects this integrative philosophy, serving as a practical guide for students, professionals, or anyone else with interests in the biotech industry. Although many books emphasize specific technical aspects of biotech, this is perhaps the first to integrate essential concepts of product development and scientific and management skills with the seven functional areas of biotechnology:

Biomanufacturing Clinical trials Nonclinical studies Project management Quality assurance Quality control Regulatory affairs

A practical roadmap to optimizing biotechnology operations, this reference illustrates how to use specific product planning, design, and project management processes to seamlessly merge plans and efforts in the key functional areas. Applying lessons learned throughout the nascent history of biotech, author Michael Roy highlights developmental principles that could bring future products to market more safely and efficiently. Drawing from his experiences working in industry and teaching a graduate course at the University of Wisconsin, this hotly anticipated book clarifies basic methodologies and practices to help reduce risks and resolve problems as future technological discoveries are developed into tangible products.

Parents can easily be bombarded by conflicting messages about vaccines a dozen times each week. One side argues that vaccines are a necessary public health measure that protects children against dangerous and potentially deadly diseases. The other side vociferously maintains that vaccines are nothing more than a sop to pharmaceutical companies, and that the diseases they allegedly help prevent are nothing more than minor annoyances. An ordinary parent may have no idea where to turn to find accurate information.

Your Baby’s Best Shot is written for the parent who does not have a background in science, research, or medicine, and who is confused and overwhelmed by the massive amount of information regarding the issue of child vaccines. New parents are worried about the decisions that they are making regarding their children’s health, and this work helps them wade through the information they receive in order to help them understand that vaccinating their child is actually one of the simplest and smartest decisions that they can make.

Covering such topics as vaccine ingredients, how vaccines work, what can happen when populations don’t vaccinate their children, and the controversies surrounding supposed links to autism, allergies, and asthma, the authors provide an overview of the field in an easy to understand guide for parents.

In an age when autism diagnoses remain on the rise, when a single infectious individual can help spark an epidemic in three countries, when doctors routinely administer an often bewildering array of shots, and when parents swear their babies were fine until their first dosage of the MMR, the authors hope this book will serve as a crucial resource to help parents understand this vitally important issue.

The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.

In the months following the September 11 attacks, world leaders began a flurry of attempts to muzzle the press. Some governments prevented journalists from covering anti-US demonstrations or criticizing US policies. Others opportunistically adopted the rhetoric of the war on terrorism to justify repressive measures against the media. Still other leaders took a cue from the tactics used by the US military in Afghanistan to keep the press away from the battlefield.

Pharmaceutical Care Practice, 3e provides the basic information necessary to establish, support, deliver, and maintain medication management services. This trusted text explains how a practitioner delivers pharmaceutical care services and provides a vision of how these services fit into the evolving healthcare structure.

Whether you are a student or a practicing pharmacist seeking to improve your patient-care skills, Pharmaceutical Care Practice, 3e provides the step-by-step implementation strategies necessary to practice in this patient-centered environment. This practical guide to providing pharmaceutical care helps you to:

Understand your growing role in drug therapy assessment and delivery Learn an effective process for applying your pharmacotherapeutic knowledge to identify and prevent or resolve drug therapy problems Establish a strong therapeutic relationship with your patients Optimize your patients’ well-being by achieving therapeutic goals Improve your follow-up evaluation abilities Documents your pharmaceutical care and obtain reimbursement Work collaboratively with other patient care providers

The patient-centered approach advocated by the authors, combined with an orderly, logical, rational decision-making process assessing the indication, effectiveness, safety, and convenience of all patient drug therapies will have a measurable positive impact on the outcomes of drug therapy.

Sometimes referred to as a "miracle diet," the ketogenic diet has helped doctors treat difficult-to-control epileptic seizures in thousands of children. Coauthored by four respected experts from Johns Hopkins, Ketogenic Diets continues to be the definitive guide for parents, physicians, and dieticians wanting to implement this strict diet. Anyone who is placed on the Ketogenic Diet will be told, essentially "prescribed" by their doctor to get this book.

This Fifth Edition has been extensively updated to reflect current advances in understanding how the diet works, how it should be used, and the future role of the diet as a treatment. Six new chapters address how to integrate the diet into all cultures, religions, and taste preferences new information on modified and less restrictive versions of the diet, and the Modified Atkins Diet for Epilepsy are included. The book also covers exciting new research that shows the diet may work for people with other neurological illnesses.

This best-seller also includes sample meal plans, a food database, how to calculate foods, and much more.

Safe and effective prescribing is a cornerstone of proper patient care. There has in recent years been a significant increase in the numbers of healthcare professionals able to prescribe; however, sources of drug information tend to focus on only one area of prescribing. The Oxford Handbook of Practical Drug Therapy links practical information about how to use medicines with concise details about the pharmacology of a drug, and the principles of clinical pharmacology that govern its action. The overall structure of this handbook is similar to the UK national formulary, with topics on each drug arranged broadly by therapeutic category. When a drug has several different uses, these are brought together in a single topic, allowing the reader to appreciate its full range of actions, whether therapeutic or adverse. Each drugs topic provides information in a clearly laid out and standardised form, and includes a graphical representation of the pharmacological actions of the drug, and its potential uses, practical advice on a drug's major indications, a list of common and serious adverse effects, major drug-drug interactions, practical advice on monitoring for therapeutic and adverse effects, and what to tell the patient. Teaching points throughout the text draw out pharmacological principles, so that readers can increase their basic knowledge by linking theory with practical examples. Also included are several boxes giving guidance on the approach to therapy of specific diseases an clinical problems. In some cases, algorithms for the treatment of medical emergencies are given, and this new edition features case histories throughout the text to illustrate the issues one may face in practical prescribing. The Oxford Handbook of Practical Drug Therapy brings together for the first time in a single book really practical information on safe prescribing, with the background knowledge that underpins clinical pharmacology. Fully revised with new guidance and important safety information, this book is aimed primarily at medical students and trainees, it will also be invaluable to family doctors, clinical pharmacists, and nurse prescribers.

Through real-time assessments of how the patient's nervous system is functioning throughout a surgical procedure, Neurophysiology in Neurosurgery presents vital techniques to guide surgeons in their efforts to minimize the risks of unintentional damage to healthy nervous tissue. This book provides a comprehensive overview of the most up-to-date intraoperative neurophysiological techniques and guidelines for the managment of neuroanesthesia during MEP monitoring. Neurophysiology in Neurosurgery is a valuable educational tool that describes the theoretical and practical aspects of intraoperative monitoring through example.

Neurophysiology in Neurosurgery is a valuable educational tool that describes the theoretical and practical aspects of intraoperative monitoring through example. The authors provide in-depth descriptions of the most advanced techniques in intraoperative neurophysiological monitoring and guidelines for the management of neuroanesthesia during MEP monitoring.

Handbook of Drug-Nutrient Interactions, Second Edition is an essential new work that provides a scientific look behind many drug-nutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored. In the five years since publication of the first edition of the Handbook of Drug-Nutrient Interactions new perspectives have emerged and new data have been generated on the subject matter. Providing both the scientific basis and clinical relevance with appropriate recommendations for many interactions, the topic of drug-nutrient interactions is significant for clinicians and researchers alike. For clinicians in particular, the book offers a guide for understanding, identifying or predicting, and ultimately preventing or managing drug-nutrient interactions to optimize patient care. Divided into six sections all chapters have been revised or are new to this edition. Chapters balance the most technical information with practical discussions and include outlines that reflect the content; discussion questions that can guide the reader to the critical areas covered in each chapter, complete definitions of terms with the abbreviation fully defined and consistent use of terms between chapters. The editors have performed an outstanding service to clinical pharmacology and pharmaco-nutrition by bringing together a multi-disciplinary group of authors. Handbook of Drug-Nutrient Interactions, Second Edition is a comprehensive up-to-date text for the total management of patients on drug and/or nutrition therapy but also an insight into the recent developments in drug-nutrition interactions which will act as a reliable reference for clinicians and students for many years to come.

This title is intended to assist pharmaceutical scientists in the development of stable protein formulations during the early stages of the product development process, providing a comprehensive review of mechanisms and causes of protein instability in formulation development, coverage of accelerated stability testing methods and relevant analytical methods, and an overview of the drug substance manufacturing process. Preformulation and the development of traditional solutions and lyophilized formulations frequently used for intravenous delivery and non-traditional formulations are also addressed. Because many developments in the field have emerged since the publication of the First Edition, this Second Edition addresses important new patient-friendly developments in the field, such as formulation for implantable devices, needle-free formulation and delivery approaches, and oral delivery of proteins.

Accurate analytical data is critical in the pharmaceutical industry. During drug development this information is used to evaluate and select formulations for use in toxicology and clinical studies, to assess manufacturing processes and to assess the suitability and stability of clinical supplies. For marketed products, analytical data is used to assess the suitability and stability of the commercial product.

Development and use of robust analytical methods is critical for the ability to generate accurate analytical data. Sample preparation is an integral part of the analytical method. In a survey conducted by LC-GC1, responses indicated that approximately two-thirds of the time spent testing and analyzing samples was spent on the sample preparation portion of the method. In addition, issues related to sample preparation accounted for one-third of the errors generated while performing an analytical method.

A number of challenges exist in the sample preparation/extraction of pharmaceutical dosage forms for potency and purity analysis as well as isolation and identification of impurities and degradants. These challenges increase for complex dosage forms such as some controlled release formulations and other challenging formulations such as suspensions, ointments, transdermal patches, etc. Challenges in developing rapid and rugged sample preparation methods include complete dispersion of the dosage form to facilitate extraction and solubilization of the analytes of interest, dealing with extracted interfering components and addressing drug-excipient interactions. A number of factors must be considered and addressed in each of these areas.

The objective of Sample Preparation of Pharmaceutical Dosage Forms is to provide an overview of the various sample preparation and extraction techniques available for pharmaceutical dosage forms. In addition to the review and discussion of specific techniques, sample preparation method development and trouble shooting strategies are discussed. Multiple examples and case studies are presented to highlight various potential issues and solutions.

Read this book in order to learn:

Why medicines often fail to produce the desired result and how such failures can be avoided

How to think about drug product safety and effectiveness

How the main participants in a medications use system can improve outcomes and how professional and personal values, attitudes, and ethical reasoning fit into drug therapy

What a properly designed and managed medications use system would look like — specific components, how the components fit together into a system, and how the system can be maintained and improved

Ways to evaluate medications use systems, how to recognize ineffective systems operations, how to identify missing system components and how to correct them

How the environment of medications use affects systems operations and patient outcomes, and why standards must change to improve drug safety and effectiveness

Drug-related illnesses and complications cost the health care system billions of dollars each year. Medical errors account for approximately 100,000 deaths each year, and drugs are the most common cause of medical errors in hospitals. Synthesizing research studies from seven nations, Preventing Medication Errors and Improving Drug Therapy Outcomes: A Management Systems Approach explores medications use from a social perspective. It identifies and describes the preventable adverse outcomes of drug therapy, discusses the safety, cost-effectiveness, and quality of medications use from a management systems perspective, and proposes systematic solutions.

 This book is a "must read" for pharmacy professionals who are ownership minded. This book contains the fundamental steps in the preparation, planning and process of starting, acquiring or selling an independent pharmacy in Canada. There are many considerations to ensure the best possible outcome.

Pharmaceutics is one of the most diverse subject areas in all of pharmaceutical science. In brief, it is concerned with the scientific and technological aspects of the design and manufacture of dosage forms or medicines. An understanding of pharmaceutics is therefore vital for all pharmacists and those pharmaceutical scientists who are involved with converting a drug or a potential drug into a medicine that can be delivered safely, effectively and conveniently to the patient.

Now in its fourth edition, this best-selling textbook in pharmaceutics has been brought completely up to date to reflect the rapid advances in delivery methodologies by eye and injection, advances in drug formulations and delivery methods for special groups (such as children and the elderly), nanomedicine, and pharmacognosy. At the same time the editors have striven to maintain the accessibility of the text for students of pharmacy, preserving the balance between being a suitably pitched introductory text and a clear reflection of the state of the art.

New to this edition

New editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London.

Twenty-two new contributors.

Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals.

Thoroughly revised and updated throughout. provides a logical, comprehensive account of drug design and manufactureincludes the science of formulation and drug deliverydesigned and written for newcomers to the design of dosage forms

New to this edition

New editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London.

Twenty-two new contributors.

Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals.

Thoroughly revised and updated throughout.

Marijuana is the prototypical cannabinoid, and is one of the most widely used drugs in the world. Interestingly, cannabinoids are molecules found naturally in the human body and brain as well as in cannabis.

This book provides an extensive reference on the biology of marijuana and the role of molecular techniques in elucidating neuropharmacological aspects of cannabinoid receptors and the endogenous compounds that act upon them. Contributions from experts from around the world describe the interaction of cannabinoids and endocannabinoids on a wide range of biological functions including movement, memory and learning, pain, emotions, endocrine functions and many more. The Biology of Marijuana: From Gene to Behavior will be of interest to all scientists and clinicians interested in the biological effects and pharmacology of this drug.

Methadone heals, but methadone kills. Methadone is a life-saving treatment, but methadone is also a life-threatening poison. The challenge is how to confer the benefit without incurring the harm. And that is what this book is all about. Methadone is by far the most widely prescribed drug in the treatment of heroin addiction, and yet, all too often, we are clumsy in our use of this powerful drug. So how much of the observed benefit is to do with methadone itself? Does dose matter? How important is the psychosocial component of care? How can problems of poor compliance be addressed? Is supervised consumption feasible, and, if so, is it justifiable and beneficial? And what is injectable methadone all about? When is it ever prescribed, and for whom, and how? And what about the dangers? Methadone itself can be the actual drug of overdose. How successful have efforts been made to re-structure methadone treatment to prevent overdose deaths? and how can the problems of diversion to the illicit market be kept to a minimum?
This multi-authored book, comprising chapters from the best of clinicians, researchers and policymakers, is the essential guide to increasing the relevance and effectiveness of methadone treatment. Like it or loathe it, Methadone Matters.

Manual of Coronary Chronic Total Occlusion Interventions: A Step-by-Step Approach is a practical, easy to read reference for coronary chronic total occlusion interventions (CTO). Written by recognized national and international experts in the field, this reference compiles the steps necessary to preform, pitfalls to watch out for, and troubleshooting needed for coronary chronic total occlusion interventions (CTO).BMA Medical Book Awards 2014 - Highly Commended, Cardiology,2014,British Medical AssociationA practical, case-oriented and easy to read reference with illustrations and step-by-step guidance for coronary chronic total occlusion interventions (CTO).Includes expert guidance reviewed by leaders in the field with both large clinical experience with high success rates and extensive experience proctoring CTOs in multiple clinical centers.

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.Multi-contributed book and chapters are written by contributors who are experts in their fieldProvides perspectives from those involved in all aspects of pharmacogenomics—including academic, regulatory, economic, industry and medical—to illustrate how all of the pieces fit together and where the challenges may beIncludes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applicationsChapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

Sample size calculation plays an important role in clinical research. It is not uncommon, however, to observe discrepancies among study objectives (or hypotheses), study design, statistical analysis (or test statistic), and sample size calculation. Focusing on sample size calculation for studies conducted during the various phases of clinical research and development, Sample Size Calculation in Clinical Research explores the causes of discrepancies and how to avoid them.

This volume provides formulas and procedures for determination of sample size required not only for testing equality, but also for testing non-inferiority/superiority, and equivalence (similarity) based on both untransformed (raw) data and log-transformed data under a parallel-group design or a crossover design with equal or unequal ratio of treatment allocations. It contains a comprehensive and unified presentation of statistical procedures for sample size calculation that are commonly employed at various phases of clinical development. Each chapter includes, whenever possible, real examples of clinical studies from therapeutic areas such as cardiovascular, central nervous system, anti-infective, oncology, and women's health to demonstrate the clinical and statistical concepts, interpretations, and their relationships and interactions.

The book highlights statistical procedures for sample size calculation and justification that are commonly employed in clinical research and development. It provides clear, illustrated explanations of how the derived formulas and/or statistical procedures can be used.

This book provides a user-friendly, hands-on introduction to the Nonlinear Mixed Effects Modeling (NONMEM) system, the most powerful tool for pharmacokinetic / pharmacodynamic analysis.
• Introduces requisite background to using Nonlinear Mixed Effects Modeling (NONMEM), covering data requirements, model building and evaluation, and quality control aspects
• Provides examples of nonlinear modeling concepts and estimation basics with discussion on  the model building process and applications of empirical Bayesian estimates in the drug development environment
• Includes detailed chapters on data set structure, developing control streams for modeling and simulation, model applications, interpretation of NONMEM output and results, and quality control
• Has datasets, programming code, and practice exercises with solutions, available on a supplementary website

Drugs During Pregnancy and Lactation, 3rd Edition is a quick and reliable reference for all those working in disciplines related to fertility, pregnancy, lactation, child health and human genetics who prescribe or deliver medicinal products, and to those who evaluate health and safety risks. Each chapter contains twofold information regarding drugs that are appropriate for prescription during pregnancy and an assessment of the risk of a drug when exposure during pregnancy has already occurred. Thoroughly updated with current regulations, references to the latest pharmacological data, and new medicinal products, this edition is a comprehensive resource covering latest knowledge and findings related to drugs during lactation and pregnancy. Provides evidence-based recommendations to help clinicians make appropriate recommendationsUniquely organized and structured according to drug class and treatment indications to offer authoritative clinical content on potential adverse effects Highlights new research developments from primary source about working mechanism of substances that cause developmental disorders