There are many biochemistry textbooks in the market. Some of them are purely basic while others are applied, and there are very few books which cover both these aspects together. For this reason, the students learning biochemistry in their undergraduate courses have to depend on multiple books to acquire a sound knowledge of the subject.
This book, ‘Biochemistry’ is unique with a simultaneous and equal emphasis on basic and applied aspects of biochemistry. This textbook offers an integration of medical and pure sciences, comprehensively written to meet the curriculum requirements of undergraduate courses in medical, dental, pharmacy, life-sciences and other categories (agriculture, veterinary, etc.).
This book is designed to develop in students a sustained interest and enthusiasm to learn and develop the concepts in biochemistry in a logical and stepwise manner. It incorporates a variety of pedagogic aids, besides colour illustrations to help the students understand the subject quickly and to the maximum. The summary and biomedical/clinical concepts are intended for a rapid absorption and assimilation of the facts and concepts in biochemistry. The self-assessment exercises will stimulate the students to think rather than merely learn the subject. In addition, these exercises (essays, short notes, fill in the blanks, multiple choice questions) set at different difficulty levels, will cater to the needs of all the categories of learners.
New to This Edition
The book offers an integration of medical and pure sciences, and is comprehensively written, revised and updated to meet the curriculum requirements of Medical, Pharmacy, Dental, Veterinary, Biotechnology, Agricultural Sciences, Life Sciences, and others studying Biochemistry as one of the subjects.
It is the first text book on Biochemistry in English with multi-colour illustrations by an author from Asia. The use of multicolours is for a clearer understanding of the complicated biochemical reactions.
It is written in a lucid style with the subject being presented as an engaging story growing from elementary information to the most recent advances, and with theoretical discussions being supplemented with illustrations, flowcharts, and tables for easy understanding of Biochemistry.
It has each chapter beginning with a four-line verse followed by the text, biomedical concepts, a summary, and self-assessment exercises. The lively illustrations and text with appropriate headings and sub-headings in bold type faces facilitate reading path clarity and quick recall.
It provides the most recent and essential information on Molecular Biology and Biotechnology, Diabetes, Cancer, Free Radicals, Free radicals and Antioxidants, Prostaglandins, etc.
It describes a wide variety of case studies and biochemical correlations and several newer biomedical aspects- Metabolic syndrome, Therapeutic diets, Atkins diet, Trans fatty acids, Epigenetics, Nutrigenomics, Recombinant ribozymes, Membrane transport disorders, Pleural fluid etc.
It contains the basics (Bioorganic and Biophysical Chemistry, Tools of Biochemistry, Immunology, and Genetics) for beginners to learn easily Biochemistry, origins of biochemical words, confusables in Biochemistry, principles of Practical Biochemistry, and Clinical Biochemistry Laboratory.
Each chapter ends with clinical cases and the related questions, which evokes yet another method of active learning rather than didactic methods of imparting knowledge.
Key points have been highlighted and boxed at the end of each topic for quick revision of the core concepts.
This book comes with a free companion website which contains self-assessment exercises, detailed case discussions related to the clinical cases given inside the book, glossary and various other features for enhanced learning.
A Doody's Core Title for 2017!
THE BEST REVIEW FOR THE USMLE!
The Thirtieth Edition of Harper’s Illustrated Biochemistry combines outstanding full-colorillustrations with authoritative integrated coverage of biochemical disease and clinical information. Using brevity and numerous medically relevant examples, Harper's presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school.
All fifty-eight chapters emphasize the medical relevance of biochemistryFull-color presentation includes more than 600 illustrations Each chapter includes a section on BiomedicalImportance and a summary of the topics covered Review questions follow each of the eleven sections Case studies in every chapter emphasize the clinical relevance to biochemistry NEW coverage of toxic naturally-occurring amino acids; extraterrestrial biomolecules; computer-aided drug design; the role of complement cascade in bacterial and viral infection; secreted mediators of cell-cell signaling between leukocytes; the role of mast cells, basophils, andeosinophils; and the hazard of antioxidants that down-regulate radical signaling for apoptosis and increase risk of cancer
Applauded by medical students for its current and engaging style, Harper's Illustrated Biochemistry is an essential for USMLE review and the single best reference for learning the clinical relevance of any biochemistry topic.
Imaging Informatics Professionals (IIPs) have come to play an indispensable role in modern medicine, and the scope of this profession has grown far beyond the boundaries of the PACS. A successful IIP must not only understand the PACS itself, but also have knowledge of clinical workflow, a base in several medical specialties, and a solid IT capability regarding software interactions and networking. With the introduction of a certification test for the IIP position, a single source was needed to explain the fundamentals of imaging informatics and to demonstrate how those fundamentals are applied in everyday practice. Practical Imaging Informatics describes the foundations of information technology and clinical image management, details typical daily operations, and discusses rarer complications and issues.
In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced with talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?
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1. Introduction to Biochemistry
3. Atom and chemical bonds
5. General Structure of Proteins
6. Classification of Proteins
8. Nucleic Acids
10. Concepts of Metabolism
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The concept of developability involves making rational choices at the pre-clinical stages of biopharmaceutical drug development that could positively impact clinical outcomes. The book also addresses a general lack of awareness of the many different contributions that computation can make to biopharmaceutical drug development.
This informative and practical reference is a valuable resource for professionals engaged in industrial research and development, scientists working with regulatory agencies, and pharmacy, medicine, and life science students and educators. It focuses primarily on the developability of monoclonal antibody candidates, but the principles described can also be extended to other modalities such as recombinant proteins, fusion proteins, antibody drug conjugates and vaccines.
The book is organized into two sections. The first discusses principles and applications of computational approaches toward discovering and developing biopharmaceutical drugs. The second presents best practices in developability assessments of early-stage biopharmaceutical drug candidates.
In addition to raising awareness of the promise of computational research, this book also discusses solutions required to improve the success rate of translating biologic drug candidates into products available in the clinic. As such, it is a rich source of information on current principles and practices as well as a starting point for finding innovative applications of computation towards biopharmaceutical drug development.
The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this, but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques, the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics, energetics, and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.
The first edition described the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions.
The second edition will include coverage of the many new discoveries that have been made in the last five years: hCG analogues may be the actual driving signal of all human cancers. The editor estimates that 40% of the out of date material will be excluded and replaced with 40% of the exciting new findings. The book will also have a much clearer pregnancy and cancer focus.It provides comprehensive information on hCG from basic science to clinical medicineThe second edition will include coverage of the many new discoveries that have been made in the last five yearsUpdated material with new findings in the field
The book maintains a concise focus on eukaryotic cell biology as it relates to human and animal disease, all within a manageable 300-page format. This is accomplished by explaining general cell biology principles in the context of organ systems and disease.
This updated version contains 60% new material and all new clinical cases. New topics include apoptosis and cell death from a neural perspective; signal transduction as it relates to normal and abnormal heart function; and cell cycle and cell division related to cancer biology.60% New Material!New Topics include: Apoptosis and cell dealth from a neural perspectiveSignal transduction as it relates to normal and abnormal heart functionCell cycle and cell division related to cancer biologyAll new clinical cases Serves as a prep guide to the National Medical Board Exam with sample board-style questions (using Exam Master(R) technology): www.exammaster.com Focuses on eukaryotic cell biology as it related to human disease, thus making the subject more accessible to pre-med and pre-health students
Gauge your mastery of the material and build confidence with both case-based, andUSMLE-style questions that provide effective chapter review and quick practice for your exams.
This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included.Grasp and retain vital concepts more easily thanks to a color-coded format, succinct,text, key concept boxes, and dynamic illustrations that facilitate learning in a highly visual approach.
Effectively review for problem-based courses with the help of text boxes that help you clearly see the clinical relevance of the material.
The Fourth Edition includes new or expanded sections and information for:
* PET/MR, including the attenuation correction method and its quality control tests;
* accreditation of nuclear medicine and PET facilities;
* solid state digital cameras;
* time of flight and scatter correction techniques;
* CT scanners and attenuation correction in SPECT/CT;
* partial volume effects;
* quality control of CT scanners;
* ion chamber survey meters, proportional counters, and G-M counters.
Jeannine Yon-Kahn, Emeritus Director of Research at the CNRS, created and directed the Laboratory of Physicochemical Enzymology at the University of Paris-Sud (Orsay, France). She was Director of Doctoral Studies in the Structure, Function and Engineering of Proteins. She was a member of several Scientific Committees (including CNRS and INRA) and is a foreign member of the Brazilian Academy of Sciences.
Guy Hervé, Emeritus Director of Research at the CNRS, was Director of the CNRS Institute of Enzymology and of one of the Biochemistry Laboratories at the Pierre and Marie Curie University in Paris. He was also Director of the Doctoral School of Molecular and Cellular Biology at that same university and President of the French Biophysical Society.
This is the first book devoted entirely to intrapartum ultrasound for the management of labor. Experts in the field present their own experiences and summarize the published state of the art. The use of intrapartum ultrasonography in evaluation of the first and second stages of labor and diagnosis of the occiput posterior and transverse positions is clearly documented. Each situation is analyzed with the help of informative images, and invaluable tips and tricks are provided, showing how fetal head engagement and progression can be documented objectively. The importance of ultrasound in obstetrics risk management is also addressed.
This book explains how intrapartum ultrasonography can be used to assess whether a safe natural delivery is likely or whether operative procedures are required. We hope it will be valuable for all professionals, physicians and midwifes alike, who care for labouring women.
Presents Groundbreaking Findings on Folate’s Role in Health
New insights related to folate chemistry, bioavailability, kinetics, metabolism, nutrient-gene, and nutrient-nutrient interaction are coupled with a public health/clinical medicine perspective of research findings targeted to birth defects, vascular and neurological diseases, and cancer. Epidemiological evidence is interpreted in tandem with new findings related to folate’s mechanistic role in health maintenance and disease/birth defect prevention. Global recommendations for folate intake and a synopsis of folic acid fortification programs are featured. Folate acid intake and status in the U.S. are described in relation to the impact of fortification. A comprehensive critique of analytical techniques for folate analysis provides a valuable resource for future investigations as well as an interpretation of existing studies.
Contributions from 50+ International Experts
This authoritative text covers:
Folate-related genetic polymorphisms and birth defect risk Folic acid fortification programs and effects on NTDs Vitamin B12 and choline interactions with folate Alcohol’s influence on folate status and methionine metabolism Clinical folate deficiency and assessment Folate intake recommendations globally; consumption and status in the U.S.
Assembling more than 50 international experts working on the front lines of folate research, this standard-setting reference brings you up to speed on the explosion of information garnered from a wealth of new developments. It continues to be a must-have resource for investigators in both basic and applied research and scientists and nutritionists in academia, clinical medicine, and public health.
Present therapies for most of these diseases are not adequate. Using the models of two long anti-atherogenic and anti-inflammatory proteins (apolipoprotein A-I and apolipoprotein E with 243 and 299 amino acids, respectively) short mimetic peptides of 18 to 28 amino acid residues in length, which can be produced either synthetically or genetically in edible fruits and vegetables, have been shown to exert profound biological effects in a large number of animal models of diseases.
The book also presents novel ideas, highly unexpected mechanisms of action in animal models and even in initial clinical studies in humans, which can lead to additional improvements in basic and clinical research in biological science. All the chapters are written by experts in their respective fields who have contributed immensely to the literature. This is the first compendium of this growing field presented in the form of a book.
Originally published in 1949.
The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Established research, including prevention and treatment of cardiovascular disease, metabolic syndrome, and cancer Emergent research, including angiogenesis, bioavailability, bone health, gastric injury, inflammation, life extension, and skin health Tocopherol interference with tocotrienol functions All new chapters and many new contributors
Recognized as potent antioxidants, tocotrienols play a role in cholesterol reduction, tumor suppression, reversal of arteriosclerosis, and protection of the heart against oxidative stress. Compiling contributions from leading researchers, this book overviews tocotrienols, and examines their sources, chemistry, and mechanisms of action. Contributors discuss the role of tocotrienols in the treatment and prevention of cancer and in cardiovascular health, diabetes, and other hormone regulation by tocotrienols. In addition, the book addresses animal and in vitro as well as mechanistic and pre-clinical studies.Dr. Tan discusses the benefits of tocotrienol in a YouTube video.
Updated and significantly expanded from previous editions, Textbook of Hyperbaric Medicine, 6th Edition will continue to be the definitive guide to this burgeoning field for students, trainees, physicians and specialists.
Integrates the clinical perspective throughout the text, giving context and meaning to biochemistry.
Frames every chapter with helpful synopses and summaries, and ends each chapter with review questions that reinforce major themes.
Illustrates key concepts with beautifully clear drawings and diagrams of biochemical processes which are supplemented with art from the renowned Netter collection, bridging basic sciences with clinical practice.
This technique-specific book is primarily of benefit to those in training in general radiology and more specifically for Residents and Fellows who are training in interventional radiology and who may be taking subspeciality certificate examinations in interventional radiology. In addition, this book will be of help to most practicing interventional radiologists, be they be in academic or private practice. This is the kind of book that can be left in the interventional lab and will be of benefit to ancillary staff, such as technicians/radiographers or nurses who are specialising in the care of patients referred to interventional radiology.
This volume on neurointervention will enhance the series by expounding on the specific techniques required when working on conditions of the head, neck and spine.
The series comprises a number of titles, which cover procedures in angioplasty and stenting, transcatheter embolization and therapy, biopsy and drainage, ablation, pediatric interventional radiology and neurointerventional radiology.
Each book is laid out in bullet point format, so that the desired information can be located quickly and easily. Interventional radiologists at all stages, from trainees through to specialists, will find this book a valuable asset for their practice.
Interventional Radiology Techniques in Ablation is a practical and concise guide to contemporary techniques in image-guided tumor ablation. This handbook is intended to serve as a quick reference for physicians in interventional radiology training as well as a resource for IR technologists, nurses, nurse practitioners and physician assistants.
Erik Seedhouse is eminently qualified to describe the effects of large accelerations on the body. In addition to being the author of several previously published Springer Praxis books, he has developed astronaut-training protocols and is the training director for Astronauts for Hire (A4H). He is also the Canadian Forces’ High Risk Acceleration Training Officer.
Detailed calculation steps, useful comments, and mathematical hints enhance solved problems throughout...
Encouraging the use of the Ratio Method, the author draws attention to its applicability to a wide variety of biochemistry problems with logical consistency and intuitive ease. This entirely revised and updated second edition introduces three new chapters with coverage of laboratory-oriented calculations and data presentation, calculations relating to the emerging techniques in DNA and molecular biology, and applying the Ratio Method to pharmaceutical calculations.
New edition adds questions and extra tips in every chapter to help students perform biochemical calculations on their own!
By strengthening their understanding of mathematical logic and problem solving skills, Fundamentals of Biochemical Calculations, Second Edition enables students and biochemists to explore a wider range of real-world applications with the ability to tackle increasingly complex problems in biochemistry and related fields.
This important guide/reference presents a comprehensive overview of medical image analysis. Highly practical in its approach, the text is uniquely structured by potential applications, supported by exercises throughout. Each of the key concepts are introduced in a concise manner, allowing the reader to understand the interdependencies between them before exploring the deeper details and derivations.
Topics and features: presents learning objectives, exercises and concluding remarks in each chapter, in addition to a glossary of abbreviations; describes a range of common imaging techniques, reconstruction techniques and image artefacts; discusses the archival and transfer of images, including the HL7 and DICOM standards; presents a selection of techniques for the enhancement of contrast and edges, for noise reduction and for edge-preserving smoothing; examines various feature detection and segmentation techniques, together with methods for computing a registration or normalisation transformation; explores object detection, as well as classification based on segment attributes such as shape and appearance; reviews the validation of an analysis method; includes appendices on Markov random field optimization, variational calculus and principal component analysis.
This easy-to-follow, classroom-tested textbook is ideal for undergraduate and graduate courses on medical image analysis and related subjects – with possible course outlines suggested in the Preface. The work can also be used as a self-study guide for professionals in medical imaging technology, and for computer scientists and engineers wishing to specialise in medical applications.
Providing a practical learning experience with numerous opportunities for self-testing, the book contains:
Checklists of what students need to know before they begin to study a topic Checklists of concepts to be fully understood before moving to the next subject area Homework problems directly tied to each concept at the end of each chapter Embedded problems with answers throughout the material Experimental details and mechanisms for key reactions
The reactions and mechanisms contained in the book describe the most fundamental concepts that are used in industry, biological chemistry and biochemistry, molecular biology, and pharmacy. The concepts presented constitute the fundamental basis of life processes, making them critical to the study of medicine. Reflecting this emphasis, most chapters end with a brief section that describes biological applications for each concept. This text provides students with the skills to proceed to the next level of study, offering a fundamental understanding of acids and bases applied to organic transformations and organic molecules.
The editors have built Amylases—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about alpha-Amylases in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Amylases—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility.