Chairman: Dennis Murphy, 1986
Depression is a common and often debilitating affective disorder. Attempts to develop effective antidepressants have a long history, but many questions remain about the mechanisms of action of such treatments and about the aetiology and pathophysiology of depression itself. Early observations centred attention on central monoamine systems, and animal studies suggested that changes in beta-adrenoceptor responsiveness were a common effect of antidepressant therapies. More recent research has encompassed many different central and peripheral receptors, time-dependent adaptational events at synapses, and the functional significance of changes in neurotransmitter systems in both humans and experimental animals. Such pharmacological studies aimed ultimately at elucidating the neurochemical basis of depression and of promoting new therapeutic approaches, provide the focus of this symposium volume. Many different methods of investigating the links between monoamine systems, depression and antidepressant treatments are described. Recent studies of receptors and of monoamine uptake sites in the brain and the periphery (e.g. in platelets and fibroblasts) are reviewed, with emphasis on alpha and beta adrenoceptors, [3H]imipramine-binding sites and serotonin receptors. The results of monitoring amine metabolites in cerebrospinal fluid and of measuring neuroendocrine, physiological and behavioural responses to pharmacological challenge are presented, providing information on monoaminergic function in depressed patients and experimental animals before, during and after treatment with antidepressant drugs or electroconvulsive shock. Genetic influences on receptor density are also discussed, as is the relevance to human depressive illness of animal models, including stress-induced behavioural depression in rats and responses to social stressors in rhesus monkeys.
This book should be of interest to neuropharmacologists, psychopharmacologists, clinical pharmacologists, behavioural scientists, psychiatrists and neuroscientists.
Chairman: Stuart B. Levy, 1997
Over the last 50 years, the rapid increase in the use of antibiotics, not only in people, but also in animal husbandry and agriculture, has delivered a selection unprecedented in the history of evolution. Consequently, society is facing one of its gravest public health problems-the emergence of infectious bacteria with resistance to many, and in some cases all, available antibiotics. This book brings together a multidisciplinary group of experts to discuss this problem. It begins by examining the origins of resistance and goes on to look at how the use of antibiotics in human medicine and farming/agriculture has selected for resistant bacteria. Separate chapters describe the evolution of resistance determinants and how these are spread both within and between bacterial species. Finally, the book contains discussions on strategies for countering the threat of antibiotic resistance. A major re-thinking of our approach to the treatment of infectious diseases is proposed-that antibiotic resistance should be seen as a problem created by the disruption of normal microbial ecology. To restore efficacy to earlier antibiotics, and to maintain the success of new antibiotics that are introduced, we need to use these drugs in a way that ensures an ecological balance that favours the predominance of susceptible bacteria.
Guidelines for Cardiac Rehabilitation and Secondary Prevention Programs, Fifth Edition, covers the entire scope of practice for cardiac rehabilitation and secondary prevention (CR/SP) programs. This text was developed by the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR) and parallels federal guidelines for cardiac rehabilitation programs. It contains information on promoting positive lifestyle behavior patterns, reducing risk factors for disease progression, and lessening the impact of cardiovascular disease on quality of life, morbidity, and mortality.
Internists, family physicians, physician's assistants, respiratory therapists, and pharmacists will find this unparalleled, authoritative guide has everything needed to understand and treat asthma in children and adults.
Ideal for preparing for certification as an asthma educator (AE-C), The Asthma Book includes important information such as:How to develop an asthma action plan based on the principles of assessing and treating asthma attacks Diagnosis and staging ambulatory asthma treatment Inhalers and inhalation aids Managing asthmatic attacks Chapter-ending Q&As that simulate the types of questions likely to appear on the National Asthma Educators Certification Board Exam Series of case discussions which test your knowledge by asking you to assume the role of an asthma educator
Dail and Hammar’s Pulmonary Pathology has set the standard for which all other pathology texts strive to achieve. From stellar reviews of the Second Edition:
"When the first edition of Pulmonary Pathology by David H. Dail and Samuel P. Hammar was published in 1988, it was clear that it was to become the reference book for pulmonary pathology. It was difficult to conceive then that a better book on the subject could be assembled. The second edition of this encyclopedic work proved convincingly that improvement could occur. Indeed, the new revised edition is more complete and better illustrated...I consider this book to be an outstanding contribution to the pathology literature and a must in the library of surgical and pulmonary pathologists." -- Human Pathology
This book presents a comprehensive overview of both pathophysiological and practical aspects of circulatory and respiratory extracorporeal support. The basics of ECMO, including its history, the “ECMO team”, cannulation, materials, and blood-surface interactions, are first discussed. The various indications for and particular characteristics of circulatory and respiratory extracorporeal life support are then described in detail in the main part of the book. Patient care during ECMO and monitoring of the ECMO patient are also carefully covered, with explanation of the management of technical and clinical complications and transport-related problems. Further topics include long-term therapy options beyond ECMO, such as ventricular assist devices and transplants, outcome, the new frontiers of ECMO for organ procurement and future challenges.
The authors are well-known experts in the field whose authoritative contributions and attention to practical aspects will be invaluable for novices and experienced practitioners alike.