Chairman: Dennis Murphy, 1986
Depression is a common and often debilitating affective disorder. Attempts to develop effective antidepressants have a long history, but many questions remain about the mechanisms of action of such treatments and about the aetiology and pathophysiology of depression itself. Early observations centred attention on central monoamine systems, and animal studies suggested that changes in beta-adrenoceptor responsiveness were a common effect of antidepressant therapies. More recent research has encompassed many different central and peripheral receptors, time-dependent adaptational events at synapses, and the functional significance of changes in neurotransmitter systems in both humans and experimental animals. Such pharmacological studies aimed ultimately at elucidating the neurochemical basis of depression and of promoting new therapeutic approaches, provide the focus of this symposium volume. Many different methods of investigating the links between monoamine systems, depression and antidepressant treatments are described. Recent studies of receptors and of monoamine uptake sites in the brain and the periphery (e.g. in platelets and fibroblasts) are reviewed, with emphasis on alpha and beta adrenoceptors, [3H]imipramine-binding sites and serotonin receptors. The results of monitoring amine metabolites in cerebrospinal fluid and of measuring neuroendocrine, physiological and behavioural responses to pharmacological challenge are presented, providing information on monoaminergic function in depressed patients and experimental animals before, during and after treatment with antidepressant drugs or electroconvulsive shock. Genetic influences on receptor density are also discussed, as is the relevance to human depressive illness of animal models, including stress-induced behavioural depression in rats and responses to social stressors in rhesus monkeys.
This book should be of interest to neuropharmacologists, psychopharmacologists, clinical pharmacologists, behavioural scientists, psychiatrists and neuroscientists.
Chairman: Stuart B. Levy, 1997
Over the last 50 years, the rapid increase in the use of antibiotics, not only in people, but also in animal husbandry and agriculture, has delivered a selection unprecedented in the history of evolution. Consequently, society is facing one of its gravest public health problems-the emergence of infectious bacteria with resistance to many, and in some cases all, available antibiotics. This book brings together a multidisciplinary group of experts to discuss this problem. It begins by examining the origins of resistance and goes on to look at how the use of antibiotics in human medicine and farming/agriculture has selected for resistant bacteria. Separate chapters describe the evolution of resistance determinants and how these are spread both within and between bacterial species. Finally, the book contains discussions on strategies for countering the threat of antibiotic resistance. A major re-thinking of our approach to the treatment of infectious diseases is proposed-that antibiotic resistance should be seen as a problem created by the disruption of normal microbial ecology. To restore efficacy to earlier antibiotics, and to maintain the success of new antibiotics that are introduced, we need to use these drugs in a way that ensures an ecological balance that favours the predominance of susceptible bacteria.
Guidelines for Cardiac Rehabilitation and Secondary Prevention Programs, Fifth Edition, covers the entire scope of practice for cardiac rehabilitation and secondary prevention (CR/SP) programs. This text was developed by the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR) and parallels federal guidelines for cardiac rehabilitation programs. It contains information on promoting positive lifestyle behavior patterns, reducing risk factors for disease progression, and lessening the impact of cardiovascular disease on quality of life, morbidity, and mortality.
First prize in Basic and Clinical Sciences, BMA Book Awards 2012
Roitt's Essential Immunology - the textbook of choice for students and instructors of immunology worldwide
Bringing you fully up-to-date with the latest knowledge and concepts about the workings of the immune system, the hallmark easy-reading style of Roitt's Essential Immunology clearly explains the key principles needed by medical and health sciences students, from the basis of immunity to clinical applications.
Beautifully presented, with brand new illustrations, the pedagogy has been strengthened throughout, and includes “just to recap…” sections at the beginning of each chapter, reminding the reader of key findings and principles, and summary sections at the end of each chapter that are ideal for quick study and revision.
Also available as a FREE enhanced Wiley Desktop Edition (upon purchase of the book), Roitt's Essential Immunology is supported by a suite of online resources at www.roitt.com including:Interactive MCQs and SBA questions for each chapter, with feedback on all answers selected Animations and videos showing key concepts Fully downloadable figures and illustrations, further reading and useful links Extracts from the Encyclopaedia of Life Science Podcasts to reinforce the key principles explained in the text: ideal for revision 'on the go' This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.
Essentials of Clinical Immunology covers the underlying pathophysiology, the signs and symptoms of disease, the investigations required and guidance on the management of patients.
Perfect for clinical medical students, junior doctors and medical professionals seeking a refresher in the role of immunology in clinical medicine, this comprehensive text features fully updated clinical information, boxes with key points, real-life case histories to illustrate key concepts and an index of contents at the start of each chapter.
A companion website at www.immunologyclinic.com provides additional learning tools, including more case studies, interactive multiple-choice questions and answers, all of the photographs and illustrations from the book, links to useful websites, and a selection of review articles from the journal Clinical and Experimental Immunology.
This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.
Internists, family physicians, physician's assistants, respiratory therapists, and pharmacists will find this unparalleled, authoritative guide has everything needed to understand and treat asthma in children and adults.
Ideal for preparing for certification as an asthma educator (AE-C), The Asthma Book includes important information such as:How to develop an asthma action plan based on the principles of assessing and treating asthma attacks Diagnosis and staging ambulatory asthma treatment Inhalers and inhalation aids Managing asthmatic attacks Chapter-ending Q&As that simulate the types of questions likely to appear on the National Asthma Educators Certification Board Exam Series of case discussions which test your knowledge by asking you to assume the role of an asthma educator
Dail and Hammar’s Pulmonary Pathology has set the standard for which all other pathology texts strive to achieve. From stellar reviews of the Second Edition:
"When the first edition of Pulmonary Pathology by David H. Dail and Samuel P. Hammar was published in 1988, it was clear that it was to become the reference book for pulmonary pathology. It was difficult to conceive then that a better book on the subject could be assembled. The second edition of this encyclopedic work proved convincingly that improvement could occur. Indeed, the new revised edition is more complete and better illustrated...I consider this book to be an outstanding contribution to the pathology literature and a must in the library of surgical and pulmonary pathologists." -- Human Pathology