The book begins by reviewing the basic mechanisms of immunity and cellular mechanisms of cytokine activation. It discusses the effects of dietary fat intake and changes in Western diet and lifestyle linked to inflammation. It also describes the interaction of genetics and environment in the modulation of immune function and inflammation, and addresses exercise and skeletal muscle as an endocrine and immune organ. The book reviews the entire spectrum of inflammation and cancer from causation to its role in tumor therapy. It examines abdominal obesity and metabolic diseases, interactions between nutrition and autoimmunity in systemic lupus erythematosus and rheumatoid arthritis, and inflammation associated with type 2 diabetes, heart disease, kidney disease, Alzheimer’s disease, and asthma.
Considering potential nutrition-based treatments, the book explores approaches for reducing abdominal obesity, anti-inflammatory effects of phytochemicals, practical strategies for increasing fruit and vegetable intake, and anti-inflammatory properties of spice phytonutrients. In addition, it explores how uninformed food choices related to fats and oils create a balance of tissue-selective signals that produce harmful health outcomes and how to restore a healthy balance.
Inflammation, Lifestyle, and Chronic Diseases: The Silent Link describes the role of dysregulated inflammation in persistent and recurring diseases. It investigates links to lifestyle and presents research on how the suppression of proinflammatory pathways may provide opportunities for both prevention and treatment of chronic diseases. The book covers neurodegenerative diseases, pulmonary diseases, asthma, rheumatic and arthritic diseases, skin disease, heart disease, chronic wounds, infectious disease, neuropsychiatric disorders such as depression, gastrointestinal diseases, insulin resistance, and cancer, many of which are also diseases of old age.
For each chronic disease, contributors review the clinical and scientific literature and examine current and potential therapies, including conventional pharmacotherapies as well as natural products. Noting that the long-term use of steroids and nonsteroidal anti-inflammatory drugs (NSAIDs) can cause adverse side effects, many of the chapters address the role of dietary agents such as fruits, vegetables, legumes, pulses, nuts, and spices as ideal anti-inflammatory agents that can be consumed regularly. The book also suggests directions for further research. Clinical and science researchers, students, and health professionals interested in the link between inflammation, lifestyle, and chronic diseases will find this an informative resource.
For the first time, Cytotoxins and Immunotoxins for Cancer Therapy: Clinical Applications presents state-of-the-art information on various cytotoxins and immunotoxins in a single, highly anticipated publication. The editors bring together leading researchers to summarize their work and discuss clinical trial data concerning some of the most widely studied tumors. The book describes Pseudomonas exotoxin (PE)-based immunotoxins and presents the latest results from clinical trials for the treatment of recurrent glioblastoma and other human cancers. It reviews the role of ricin-based immunotoxins for the treatment of lymphoma, explores several DT-based immunotoxins, and details the preclinical and clinical development of the first FDA-approved cytotoxin.
With a focus on clinical developmental approaches to the use of cytotoxins and immunotoxins, this book discusses exciting possibilities for cancer therapy. It is a valuable resource for scientists, researchers, and clinicians involved in the development of new treatments that can help keep cancer under control, and may ultimately lead to a cure.
One of the most therapeutically significant components found in food is the polyphenol resveratrol. First described in Ayurvedic medicine 5000 years ago as a cardiotonic, resveratrol is found in several fruits and vegetables including grapes, peanuts, cranberries, blueberries, mulberries, and jackfruit. A favorite and rich source of resveratrol is red wine.
Resveratrol in Health and Disease draws on the expertise of an international panel, representing a cross-section of nutrition-related disciplines, to examine the effects and properties of this legendary nutrient. It explores research that examines a wide range of purported healing and preventive powers:
Antifungal and antibacterial agent
Modulator of immune system
Reviewing recent literature, these pages explore the pharmacokinetics and metabolism of resveratrol, consider its molecular targets, and look at its role in modulating gene expression, as well as its impact on the mechanism of apoptosis and cell signaling pathways.
Considering the prohibitive costs of modern medicine, the need for readily available products that are safe and efficacious is critical. Consequently, Resveratrol in Health and Disease may well find its own place in history by providing scientists, clinicians, herbalogists, naturopaths, and those they serve, with the first comprehensive overview of this long-lauded tonic.
PTCE (Pharmacy Technician Certification Exam) Flashcard Book
400 Questions & Answers You Need to Know
Written by a seasoned pharmacy technician instructor, this PTCE study supplement covers everything you need to know for the exam: assisting the pharmacist in serving patients, maintaining medication and inventory control systems, and participating in the management of pharmacy practice.
The 400 flashcards are broken down by PTCE test topics and include multiple-choice questions with detailed answers. We give you:
100 flashcards focused on the top 100 brand/generic drug names including their drug classes, indications, side effects, and special considerations;
50 flashcards focused on pharmaceutical terms and abbreviations and
250 flashcards focused on PTCE review material: Assisting the Pharmacist in Serving Patients (165 flashcards), Maintaining Medication and Inventory Control Systems (50 flashcards), and Participating in the Administration and Management of Pharmacy Practice (30 flashcards).
After studying with the book, review what you've learned at REA's online Study Center. Customizable e-flashcards and 3 practice quizzes let you create your own PTCE study plan and study anywhere, anytime. You can also make your own flashcards for any topics that give you difficulty.
If you're a pharmacy tech student and want extra practice and review before the exam, REA's PTCE Flashcard Book is the right Rx for your study needs.
In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group.
Key features include:
• Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups.
• How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism.
• Numerous examples and expanded discussions for complex concepts.
• Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice.
• An overview of structure activity relationships (SARs) and concepts that govern drug design.
• Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix.
Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry.
About the Authors
Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy.
Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.
NEW TO THIS EDITION:Three new chapters including new information on men’s health, women’s health, and pharmacogenomics and laboratory tests.Mini-cases embedded in each chapter provide therapy-related examples and reinforce important points made in the text.Quickview Charts give an overview of important clinical information including reference ranges and critical values.Learning Points focus on a clinical application of a major concept present in the chapter.
Government Is Us 2.0 picks up where the previous edition left off. It addresses the bigger questions that are being asked and discussed about the relationships among and between citizens and their governments, how individuals and agencies govern, and the institutional elements that keep us from engendering long-term, socially just participatory change.
The central argument of Government Is Us 2.0 is that much can be done to bridge the gulf between citizens and their governments. The chapter authors offer practical suggestions on how public administrators can productively involve citizens in government work, with steps that will increase citizens' trust in government through opportunities for direct connection and collaboration.
TechPrep™ contains more than 1,000 review questions to help readers prepare for national technician certification exams. A robust Practice Session feature allows users to create custom quizzes by setting topic area, time, and number of questions. The Simulated Exam function lets readers practice their test skills by providing a 90 question, 120 minute test, with questions weighted to mimic national certification exams. Students using TechPrep™ receive instant, automated scoring, and can quickly identify areas they’ve mastered, or practice subjects where they need improvement. Alone or with the new edition of the Manual for Pharmacy Technicians, 4th Edition andall-new Workbook for the Manual for Pharmacy Technicians, the Pharmacy Technician Review Guide and Practice Exam offers the most comprehensive review to help you achieve certification!
Although rotations are crucial to the development of skills needed to practice pharmacy, there has been little available to guide students in the best way to prepare and make the most of these experiences—until now.
Maximize Your Rotations: ASHP’s Student Guide to IPPEs, APPEs, and Beyond breaks down everything you need to know into easy-to-navigate chapters. Inside you will find the skills required to excel while on IPPE or APPE rotations, along with competencies that may be unique to one type of rotation or another.
Each chapter is written by an experienced preceptor, lending a valuable perspective.
By using this text, you will gain an appreciation of the general expectations and typical activities of each rotation experience before you begin. Better preparation means better performance. Maximize Your Rotations will also be a resource throughout the experiential year, offering everything from reminders of clinical issues and statistical reviews to advice on interviewing, CV writing, professional organizations, and more.
Maximize Your Rotations means less time getting up to speed—and more time getting ahead in your career. Your rotation experience can be the launching pad for your career, and there’s no better guide than Maximize Your Rotations.
Each chapter contains learning objectives, case studies, bibliographies, and charts that summarize the causes of high and low test results.
New for this edition: Updated and expanded Quick View tables in each chapter now match those in the popular quick-reference, Interpreting Laboratory Data: A Point-of-Care Guide New glossary of acronyms is right up front for a streamlined reference Normal value ranges of all tests have been standardized by an expert pathologist New and updated cases in each chapter apply your Basic Skills in clinical situations Reorganized to highlight the application of concepts by body system, and in special populationsBasic Skills in Interpreting Laboratory Data offers features that will help pharmacy students not only understand and engage with the material but also will streamline the transition from classroom to practice setting. After studying with this trusted text, students and pharmacists will more effectively monitor patient therapy, evaluate test results, and improve outcomes through optimal and focused pharmacotherapy.
From Abilify to Zyrtec and nearly every drug in between, Mosby's Drug Reference for Health Professions, 3rd Edition is the must-have item for every aspiring health professional. In fact, it's the only drug book on the market written specifically for health professionals! Filled with vital details your students need to know about patient medications, this updated edition features concise, reliable information that is easy to navigate and simple to follow. Key details are presented in short monographs for 1,000 generic drugs (including 4,500 trade-name drugs) that are listed alphabetically. Precautions and considerations sections are tailored to circumstances your students will face on the job. Make certain they have the most relevant information on hand for their studies and for clinical practice with Mosby's Drug Reference for Health Professions, 3rd Edition!
Decision making based on personal experience alone, without knowledge from well-designed, controlled, randomized trials with adequate sample size, often overestimates the efficacy and underestimates the safety risks associated with drugs. This book provides a roadmap that is instructional and, most importantly, practical for the pharmacist so these new skills can be applied immediately in practice.
Based on a five-step process perfected over ten years at the University of Missouri, Kansas City, School of Pharmacy, this exciting new approach will:
· Reduce complexity
· Shorten time for decision making support
· Maintain rigor
· Categorize quality of the evidence in a simple, straightforward, and logical manner
· Provide a process designed specifically for pharmacists making drug therapy decisions
Use of examples, tables, diagrams, and key points highlighted throughout the book and summarized at the end of each chapter provide the pharmacist with skills they can implement the next day to begin applying EBM principles to their practice.
Pharmacotherapy Handbook, 8e provides practitioners and students with the critical information necessary to support drug therapy decision making for more than 140 diseases and disorders. Featuring a convenient alphabetized presentation, this handy guide utilizes tables, texts, figures, and treatment algorithms to make the information readily accessible and easily understood.
The consistent chapter organization includes: Disease state definition Review of relevant pathophysiology Clinical presentation Diagnosis Desired outcome Treatment Monitoring
The Treatment section usually includes nonpharmacologic therapy, drug selection guidelines, dosing recommendations, adverse effects, pharmacokinetic considerations, and important drug interactions.
A&P content helps you understand how drugs work in the human body.
Comprehensive drug tables provide fast, easy access to essential pharmaceutical facts.
Tech Notes and Tech Alerts highlight steps you can take to enhance efficiency and avoid common errors on the job.
Pharmacist's Perspective boxes provide practical insight on common scenarios you'll encounter in practice.
Technician's Corner boxes challenge you to apply your critical thinking skills to chapter content.
Abbreviated drug monographs familiarize you with essential pharmaceutical data for common drugs:
Route of administration
Side effects Auxiliary labelMedication Safety and Error Prevention chapter helps you confidently address growing concerns related to patient safety and prevent medication-related errors.
Revised Math Calculations chapter incorporates helpful information to clarify complex pharmaceutical calculations.
Updated content prepares you for the Pharmacy Technician Certification (PTC) exam and highlights current concerns you'll encounter in the workforce:
HIPAA regulationsThe Medicare Modernization Act Legal parameters for the sale of pseudoephedrine productsThe issuance of multiple Schedule II prescriptionsPending legislation requirements for Medicaid prescriptionsThe United States Pharmacopeia (USP)
New full-color photographs familiarize you with current practice settings. Learning games and certification review quizzes on the companion Evolve website reinforce your understanding and challenge you to apply what you've learned.
3rd edition changes:
The field of oncology massage is maturing into a discipline with a deeper and deeper body of knowledge. The 3rd edition of Medicine Hands reflects this maturation. Every chapter contains updated information and insights into massaging people affected by cancer. New chapters have been added to cover each stage of the cancer experience: treatment, recovery, survivorship, side effects from the disease, and end of life. These new chapters and organizational structure will make it easier for the reader to find the information needed to plan the massage session for a given client. As well, a new chapter has been added that focuses on the Pressure/Site/Positioning framework. This is the clinical framework around which the massage session is planned.
The scientific research on the effects of massage for people with cancer is updated to 2013. New in the 3rd edition is material devoted to massaging young adult survivors, the person with breast reconstruction, cording, and late effects as well as thoughts for therapists and clients who are considering the use of massage as part of a detoxification process.
All of the features most enjoyed by past readers have been retained—the inspirational sidebar quotes, client and therapist anecdotes, info boxes, and therapists questions and answers. To augment the learning process, written exercises have been added for student therapists and all of those who want to participate in their own learning. As well, sample session write-ups have been included to show the reader the variety of touch modalities that can be used to for people living with cancer.
Finally, the 3rd edition will be full color with new color photographs.
A masterful synchronization of history and cutting-edge science shines new light on humanity's darkest diagnosis.
In the wake of the Cancer Genome Atlas project's failure to provide a legible roadmap to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease. Tripping over the Truth follows the story of cancer’s proposed metabolic origin from the vaunted halls of the German scientific golden age to modern laboratories around the world. The reader is taken on a journey through time and science that results in an unlikely connecting of the dots with profound therapeutic implications.
Transporting us on a rich narrative of humanity’s struggle to understand the cellular events that conspire to form malignancy, Tripping over the Truth reads like a detective novel, full of twists and cover-ups, blind-alleys and striking moments of discovery by men and women with uncommon vision, grit, and fortitude. Ultimately, Christofferson arrives at a conclusion that challenges everything we thought we knew about the disease, suggesting the reason for the failed war against cancer stems from a flawed paradigm that categorizes cancer as an exclusively genetic disease.
For anyone affected by this terrifying disease and the physicians who struggle to treat it, this book provides a fresh and hopeful perspective. It explores the new and exciting non-toxic therapies born from the emerging metabolic theory of cancer. These therapies may one day prove to be a turning point in the struggle against our ancient enemy. We are shown how the metabolic theory redraws the battle map, directing researchers to approach cancer treatment from a different angle, framing it more like a gentle rehabilitation rather than all-out combat. In a sharp departure from the current “targeted” revolution occurring in cancer pharmaceuticals, the metabolic therapies highlighted have one striking feature that sets them apart—the potential to treat all types of cancer because they exploit the one weakness that is common to every cancer cell: dysfunctional metabolism.
With contributions from Thomas Seyfried, PhD, author of Cancer as a Metabolic Disease; Miriam Kalamian, EdM, MS, CNS, author of Keto for Cancer; and Beth Zupec Kania, consultant nutritionist of The Charlie Foundation.
The AJCC Cancer Staging Atlas, 2nd Edition, is an official publication of the American Joint Committee on Cancer, the recognized international leader in state-of-the-art information on cancer staging. This Atlas has been created as a companion to the updated 7th Edition of the AJCC Cancer Staging Manual, which continues to disseminate the importance of anatomical and pathological staging in the management of cancer. This state-of-the-art, invaluable 2nd Edition includes a CD containing PowerPoint slides of all illustrations, additional color, and a user-friendly, easy-to-read layout. The AJCC Cancer Staging Atlas, 2nd Edition will serve as an indispensable reference for clinicians, registrars, students, trainees, and patients.
If you are a patient, gain a better understanding of how a pharmacy functions; if you are a health care provider, learn how to better communicate with retail pharmacists. A Prescription for Retail Pharmacy provides helpful advice for those already working behind the counter, as well. Explore what is expected of pharmacy technicians and new techniques for pharmacists to use in handling the typical problems they encounter.
Whether your problems are in front of the counter or behind it, A Prescription for Retail Pharmacy provides the cure!
Water Insolubility is the Primary Culprit in over 40% of New Drug Development Failures
The most comprehensive resource on the topic, this second edition of Water Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe solubility properties and their impact on formulation, from theory to industrial practice. With detailed discussion on how these properties contribute to solubilization and dissolution, the text also features six brand new chapters on water-insoluble drugs, exploring regulatory aspects, pharmacokinetic behavior, early phase formulation strategies, lipid based systems for oral delivery, modified release of insoluble drugs, and scalable manufacturing aspects. The book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field.
This book offers a complete review of the basic mathematics concepts and skills, which provide a foundation for more advanced understanding of pharmacy-related topics. The guide provides students with the pharmacy basics necessary for correctly interpreting prescriptions and drug orders, and for performing dosing calculations that technicians face every day.
The chapters are broken down into four units and are organized to complement most pharmacy technician training curricula and to support the ASHP model curriculum:
· Review of Mathematics
· Systems of Measurement
· Preparing for Problem Solving in Pharmacy
· Dosing Calculations and Other Pharmacy Problems
Key features throughout the book include:
· Chapter objectives
· Key terms and definitions
· Examples of problem scenarios or calculations questions and solutions
· “Tech Note!” —provides a highlight of key points within the chapters
· “Numbers at Work” —illustrates why key concepts are important to know and skills are critical to master
· Practice problems
· A test bank
· Appendices that include the parts of a prescription, a glossary of terms, conversions, and abbreviations tables.
For additional resources related to this book, visit www.ashp.org/techcalculations.
In telling these stories, Lippe and Le alternate chapters. Lippe writes about the early signs that something was wrong; Le continues with a description of pancreatic cancer, its symptoms, and its treatments. Lippe talks about his prognosis, contemplates the prospect of death, and describes how he began to cope; Le explains the importance, for both doctor and patient, of balancing hope and truth. Lippe speaks frankly about the toll the disease takes on his marriage and family; Le offers a general picture of what most patients can expect with their illness. The book concludes with Lippe and Le’s reflections on their partnership in treating cancer, lessons they have learned, and their thoughts about the positive things that sometimes emerge from illness.
Pancreatic Cancer offers clear explanations of what the disease is, describes what people with the disease will feel physically and mentally, and discusses current treatments and future directions of research. The authors hope that their honest yet hopeful perspective will help all people with cancer and those who care about them.
50 Critical Cancer Answers provides the essential information a person needs to create a personal action plan to deal with cancer effectively. Each of the 50 short, easy-to-digest chapters includes a concise explanation of the most effective and sought after cancer treatment in the realms of traditional medicine, natural medicine, emotional support and spiritual care. A succinct commentary is provided to help the reader understand potential benefits, and if it is a realistic treatment option or not. Each chapter includes:
- An interview with an expert in the field of the chapter's topic
- A "smartphone scannable" QR code linking the reader to You Tube video containing author commentary on the relevant topic
- 5 tips from cancer survivors--all 50 cancer survivors have received treatment from the authors' Oasis of Hope cancer centers.
Don't let a cancer diagnosis define your circumstances. Instead, develop a plan to identify, attack, and beat cancer.
Gather step-by-step techniques for assessing and implementing radiotherapeutic options with this comprehensive, full-color, clinically oriented text.
Review the basic principles behind the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, and more.Use new imaging techniques to anatomically locate tumors before and during treatment.
Apply multidisciplinary treatments with advice from experts in medical, surgical, and radiation oncology.
Explore new treatment options such as proton therapy, which can facilitate precise tumor-targeting and reduce damage to healthy tissue and organs.
Stay on the edge of technology with new chapters on IGRT, DNA damage and repair, and molecularly targeted therapies.
Pretests in each chapter allow readers to assess their current knowledge of specific topics.
Step-by-step examples make it easy to learn and remember how to do equations and use formulas.
Hundreds of practice problems provide practice with calculations, conversions, and measurements.
Actual drug labels accompany examples and problems, for real-world experience with the information you will see in pharmacy practice.
Business Math for Pharmacy Technicians chapter introduces the calculations needed in retail pharmacy settings.
Body system icons appear next to medication names to help you associate different drugs with their respective disorders and body systems.
Points to Remember boxes make it easy to learn and remember key information.
Review of Rules sections in each chapter summarize the rules and methods for performing equations.
Chapter reviews provide a quick summary of the key concepts in each chapter.
Posttests in each chapter allow you to assess how well you have learned the material.
A comprehensive posttest includes 50 questions that assess your knowledge of all major topics covered in the book.
Helpful study tools also include an answer key for odd-numbered problems and a comprehensive glossary.Updated content meets ASHP requirements and features new topics such as powder volume and compounding problems, formulas for reducing and enlarging medications, and opportunities to write out prescription label directions.
Tech Note boxes offer helpful advice on real-life situations you may encounter in the pharmacy.
Tech Alert boxes warn against common pharmacy and medication errors that could impact patients' safety.
Additional prescription and practice exercises give you valuable experience with translating physician directions into patient instructions.
Mastering Pharmacy Technician Math: A Certification Review is a super-effective way for students preparing for the Pharmacy Technician Certification Board Examination to improve their ability to perform basic math and pharmacy-specific calculations. The book includes powerful learning aids such as practice exercises in each chapter, end-of-chapter Q&A, a 50-question pretest that reviews key concepts, and three 100-question practice tests to prepare you for the board exam. All questions are correlated to the learning outcomes found in the book so you know exactly what to review should you answer a question incorrectly.
Mastering Pharmacy Technician Math: A Certification Review is logically divided into ten chapters:
Chapter 1: Mathematical Concepts -- reviews the basic mathematical building blocks needed to master advanced pharmacy calculations, including fractions, decimals, percents, ratios, proportions, conversions, and cross-multiplication.
Chapter 2: Numbering Systems -- reviews the different systems of measurement and how to convert within and between them, including working with temperatures and time.
Chapter 3: Understanding Drugs and Drug Orders -- identifies drug strengths, doses, drug forms, and routes of administration and explains how to identify and interpret information on drug labels, package inserts, prescriptions, and medication orders.
Chapter 4: Methods of Dosage Calculations -- presents methods to perform dosage calculations correctly, including fraction proportion, ratio proportion, dimensional analysis, and formulas.
Chapter 5: Oral Dosages -- describes the processes for calculating dosages, amount to dispense, and estimated days' supply for oral medications.
Chapter 6: Parenteral Dosages (Excluding Intravenous) -- describes parenteral medications, including those given by injection; inhalants; transdermal, ophthalmic, and otic drugs; and drugs placed in the rectum or vagina.
Chapter 7: Intravenous Calculations -- describes how to calculate IV concentrations and how to prepare medications for continuous and intermittent IV infusion.
Chapter 8: Special Preparations Calculations -- describes the processes to calculate concentrations, ratio strengths, final volume/final strength, and dilutions, as well as how to write recipes to prepare compound drug orders and perform alligation calculations.
Chapter 9: Medication Safety and Calculations -- discusses pharmacokinetics, high-alert medications, look-alike/sound-alike medications, how to calculate drug half-life values, pediatric and geriatric calculations, DEA controlled substance requirements related to prescriber DEA numbers, and how to perform the calculation needed to verify DEA number validity.
Chapter 10: Business, Inventory, and Reimbursement Calculations -- discusses reimbursements and patient payments, and describes how to calculate overhead costs, profits and losses, markups, turnover rates, and correct costs and change.
Development and use of robust analytical methods is critical for the ability to generate accurate analytical data. Sample preparation is an integral part of the analytical method. In a survey conducted by LC-GC1, responses indicated that approximately two-thirds of the time spent testing and analyzing samples was spent on the sample preparation portion of the method. In addition, issues related to sample preparation accounted for one-third of the errors generated while performing an analytical method.
A number of challenges exist in the sample preparation/extraction of pharmaceutical dosage forms for potency and purity analysis as well as isolation and identification of impurities and degradants. These challenges increase for complex dosage forms such as some controlled release formulations and other challenging formulations such as suspensions, ointments, transdermal patches, etc. Challenges in developing rapid and rugged sample preparation methods include complete dispersion of the dosage form to facilitate extraction and solubilization of the analytes of interest, dealing with extracted interfering components and addressing drug-excipient interactions. A number of factors must be considered and addressed in each of these areas.
The objective of Sample Preparation of Pharmaceutical Dosage Forms is to provide an overview of the various sample preparation and extraction techniques available for pharmaceutical dosage forms. In addition to the review and discussion of specific techniques, sample preparation method development and trouble shooting strategies are discussed. Multiple examples and case studies are presented to highlight various potential issues and solutions.
Why medicines often fail to produce the desired result and how such failures can be avoided
How to think about drug product safety and effectiveness
How the main participants in a medications use system can improve outcomes and how professional and personal values, attitudes, and ethical reasoning fit into drug therapy
What a properly designed and managed medications use system would look like — specific components, how the components fit together into a system, and how the system can be maintained and improved
Ways to evaluate medications use systems, how to recognize ineffective systems operations, how to identify missing system components and how to correct them
How the environment of medications use affects systems operations and patient outcomes, and why standards must change to improve drug safety and effectiveness
Drug-related illnesses and complications cost the health care system billions of dollars each year. Medical errors account for approximately 100,000 deaths each year, and drugs are the most common cause of medical errors in hospitals. Synthesizing research studies from seven nations, Preventing Medication Errors and Improving Drug Therapy Outcomes: A Management Systems Approach explores medications use from a social perspective. It identifies and describes the preventable adverse outcomes of drug therapy, discusses the safety, cost-effectiveness, and quality of medications use from a management systems perspective, and proposes systematic solutions.
Now in its fourth edition, this best-selling textbook in pharmaceutics has been brought completely up to date to reflect the rapid advances in delivery methodologies by eye and injection, advances in drug formulations and delivery methods for special groups (such as children and the elderly), nanomedicine, and pharmacognosy. At the same time the editors have striven to maintain the accessibility of the text for students of pharmacy, preserving the balance between being a suitably pitched introductory text and a clear reflection of the state of the art.
New to this edition
New editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London.
Twenty-two new contributors.
Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals.
Thoroughly revised and updated throughout. provides a logical, comprehensive account of drug design and manufactureincludes the science of formulation and drug deliverydesigned and written for newcomers to the design of dosage forms
New to this edition
New editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London.
Twenty-two new contributors.
Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals.
Thoroughly revised and updated throughout.
First published in 1934, Perry's Chemical Engineers' Handbook has equipped generations of engineers and chemists with an expert source of chemical engineering information and data. Now updated to reflect the latest technology and processes of the new millennium, the Eighth Edition of this classic guide provides unsurpassed coverage of every aspect of chemical engineering-from fundamental principles to chemical processes and equipment to new computer applications.
Filled with over 700 detailed illustrations, the Eighth Edition of Perry's Chemcial Engineering Handbook features:Comprehensive tables and charts for unit conversion A greatly expanded section on physical and chemical data New to this edition: the latest advances in distillation, liquid-liquid extraction, reactor modeling, biological processes, biochemical and membrane separation processes, and chemical plant safety practices with accident case histories
Inside This Updated Chemical Engineering GuideConversion Factors and Mathematical Symbols • Physical and Chemical Data • Mathematics • Thermodynamics • Heat and Mass Transfer • Fluid and Particle Dynamics Reaction Kinetics • Process Control • Process Economics • Transport and Storage of Fluids • Heat Transfer Equipment • Psychrometry, Evaporative Cooling, and Solids Drying • Distillation • Gas Absorption and Gas-Liquid System Design • Liquid-Liquid Extraction Operations and Equipment • Adsorption and Ion Exchange • Gas-Solid Operations and Equipment • Liquid-Solid Operations and Equipment • Solid-Solid Operations and Equipment • Size Reduction and Size Enlargement • Handling of Bulk Solids and Packaging of Solids and Liquids • Alternative Separation Processes • And Many Other Topics!