A masterful synchronization of history and cutting-edge science shines new light on humanity's darkest diagnosis.
In the wake of the Cancer Genome Atlas project's failure to provide a legible roadmap to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease. Tripping over the Truth follows the story of cancer’s proposed metabolic origin from the vaunted halls of the German scientific golden age to modern laboratories around the world. The reader is taken on a journey through time and science that results in an unlikely connecting of the dots with profound therapeutic implications.
Transporting us on a rich narrative of humanity’s struggle to understand the cellular events that conspire to form malignancy, Tripping over the Truth reads like a detective novel, full of twists and cover-ups, blind-alleys and striking moments of discovery by men and women with uncommon vision, grit, and fortitude. Ultimately, Christofferson arrives at a conclusion that challenges everything we thought we knew about the disease, suggesting the reason for the failed war against cancer stems from a flawed paradigm that categorizes cancer as an exclusively genetic disease.
For anyone affected by this terrifying disease and the physicians who struggle to treat it, this book provides a fresh and hopeful perspective. It explores the new and exciting non-toxic therapies born from the emerging metabolic theory of cancer. These therapies may one day prove to be a turning point in the struggle against our ancient enemy. We are shown how the metabolic theory redraws the battle map, directing researchers to approach cancer treatment from a different angle, framing it more like a gentle rehabilitation rather than all-out combat. In a sharp departure from the current “targeted” revolution occurring in cancer pharmaceuticals, the metabolic therapies highlighted have one striking feature that sets them apart—the potential to treat all types of cancer because they exploit the one weakness that is common to every cancer cell: dysfunctional metabolism.
With contributions from Thomas Seyfried, PhD, author of Cancer as a Metabolic Disease; Miriam Kalamian, EdM, MS, CNS, author of Keto for Cancer; and Beth Zupec Kania, consultant nutritionist of The Charlie Foundation.
3rd edition changes:
The field of oncology massage is maturing into a discipline with a deeper and deeper body of knowledge. The 3rd edition of Medicine Hands reflects this maturation. Every chapter contains updated information and insights into massaging people affected by cancer. New chapters have been added to cover each stage of the cancer experience: treatment, recovery, survivorship, side effects from the disease, and end of life. These new chapters and organizational structure will make it easier for the reader to find the information needed to plan the massage session for a given client. As well, a new chapter has been added that focuses on the Pressure/Site/Positioning framework. This is the clinical framework around which the massage session is planned.
The scientific research on the effects of massage for people with cancer is updated to 2013. New in the 3rd edition is material devoted to massaging young adult survivors, the person with breast reconstruction, cording, and late effects as well as thoughts for therapists and clients who are considering the use of massage as part of a detoxification process.
All of the features most enjoyed by past readers have been retained—the inspirational sidebar quotes, client and therapist anecdotes, info boxes, and therapists questions and answers. To augment the learning process, written exercises have been added for student therapists and all of those who want to participate in their own learning. As well, sample session write-ups have been included to show the reader the variety of touch modalities that can be used to for people living with cancer.
Finally, the 3rd edition will be full color with new color photographs.
The AJCC Cancer Staging Atlas, 2nd Edition, is an official publication of the American Joint Committee on Cancer, the recognized international leader in state-of-the-art information on cancer staging. This Atlas has been created as a companion to the updated 7th Edition of the AJCC Cancer Staging Manual, which continues to disseminate the importance of anatomical and pathological staging in the management of cancer. This state-of-the-art, invaluable 2nd Edition includes a CD containing PowerPoint slides of all illustrations, additional color, and a user-friendly, easy-to-read layout. The AJCC Cancer Staging Atlas, 2nd Edition will serve as an indispensable reference for clinicians, registrars, students, trainees, and patients.
In telling these stories, Lippe and Le alternate chapters. Lippe writes about the early signs that something was wrong; Le continues with a description of pancreatic cancer, its symptoms, and its treatments. Lippe talks about his prognosis, contemplates the prospect of death, and describes how he began to cope; Le explains the importance, for both doctor and patient, of balancing hope and truth. Lippe speaks frankly about the toll the disease takes on his marriage and family; Le offers a general picture of what most patients can expect with their illness. The book concludes with Lippe and Le’s reflections on their partnership in treating cancer, lessons they have learned, and their thoughts about the positive things that sometimes emerge from illness.
Pancreatic Cancer offers clear explanations of what the disease is, describes what people with the disease will feel physically and mentally, and discusses current treatments and future directions of research. The authors hope that their honest yet hopeful perspective will help all people with cancer and those who care about them.
50 Critical Cancer Answers provides the essential information a person needs to create a personal action plan to deal with cancer effectively. Each of the 50 short, easy-to-digest chapters includes a concise explanation of the most effective and sought after cancer treatment in the realms of traditional medicine, natural medicine, emotional support and spiritual care. A succinct commentary is provided to help the reader understand potential benefits, and if it is a realistic treatment option or not. Each chapter includes:
- An interview with an expert in the field of the chapter's topic
- A "smartphone scannable" QR code linking the reader to You Tube video containing author commentary on the relevant topic
- 5 tips from cancer survivors--all 50 cancer survivors have received treatment from the authors' Oasis of Hope cancer centers.
Don't let a cancer diagnosis define your circumstances. Instead, develop a plan to identify, attack, and beat cancer.
Gather step-by-step techniques for assessing and implementing radiotherapeutic options with this comprehensive, full-color, clinically oriented text.
Review the basic principles behind the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, and more.Use new imaging techniques to anatomically locate tumors before and during treatment.
Apply multidisciplinary treatments with advice from experts in medical, surgical, and radiation oncology.
Explore new treatment options such as proton therapy, which can facilitate precise tumor-targeting and reduce damage to healthy tissue and organs.
Stay on the edge of technology with new chapters on IGRT, DNA damage and repair, and molecularly targeted therapies.
Since the third edition (2003), there have been significant changes in treatment and resources. Working with Dr. Judd Moul, the Chairman of Urology at Duke and one of the world's top experts on prostate cancer, Marks provides the most up-to- date information on diagnosis, treatment, and common questions.
Faithful to its title, this text espouses a truly multidisciplinary approach, integrating information from the fields of oncology, neurosurgery, radiation oncology, and neurology. Experts in each specialty have gathered that information which is most important for all physicians caring for patients with brain metastasis.
Brain Metastasis includes complete discussions for all situations in which radiosurgery might be recommended, including for the treatment of gross brain metastasis; for the prevention of tumor-related injury of brain function; and as an alternative to whole-brain radiotherapy.
Features of this uniquely accessible guide include:
A timely discussion of exciting recent developments in aggressive care An emphasis on quality-of-life issues and palliative care Special chapters on radiosurgery for both brain metastasis and spinal tumors Full color insert of high-quality images
This concise and comprehensive text provides a multidisciplinary information source for brain metastasis. It is an essential resource for any practitioner who cares for patients with this devastating yet surprisingly common condition.
The book opens with an introduction to the principles of hybrid imaging that pays particular attention to PET/MR imaging and standard PET/MR acquisition protocols. A wide range of illustrated clinical case reports are then presented. Each case study includes a short clinical history, findings, and teaching points, followed by illustrations, legends, and comments.
The multimedia version of the book includes dynamic movies that allow the reader to browse through series of rotating 3D images (MIP or volume rendered), display blending between PET and MR, and dynamic visualization of 3D image volumes. The movies can be played either continuously or sequentially for better exploration of sets of images.
The editors of this state-of-the-art publication are key opinion leaders in the field of multimodality imaging. Professor Osman Ratib (Geneva) and Professor Markus Schwaiger (Munich) were the first in Europe to initiate the clinical adoption of PET/MR imaging. Professor Thomas Beyer (Zurich) is an internationally renowned pioneering physicist in the field of hybrid imaging. Individual clinical cases presented in this book are co-authored by leading international radiologists and nuclear physicians experts in the use of PET and MRI.
The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.
Taking a unique multi-disciplinary approach, the book covers conventional histopathology and cytopathology, as well as all important complementary diagnostic tests, such as immunophenotyping (immunohistochemical stains and flow cytometry), karyotyping, FISH and DNA/molecular studies. It offers concise textual and extensive visual coverage of both neoplastic and non-neoplastic hematology disorders, with the neoplastic hematology sections presented according to the most recent WHO classifications. There is also an introduction to the normal structures of hematopoietic tissues and the various multidisciplinary techniques.
The atlas contains more than 900 high-quality color images that mirror the findings that fellows and clinicians encounter in practice. It provides information in a quick, simple and user-friendly manner, attracting those who are in training or are not considered experts in the field. Residents, fellows, practicing clinicians, and researchers in pathology, hematology, hematology/oncology, as well as graduate students in pathology and other clinicians workings in clinical hematology laboratories will all find it useful.Saves clinicians and researchers time in quickly accessing the very latest details on the diverse clinical and scientific aspects of hematopathology, as opposed to searching through thousands of journal articles For clinicians, fellows, and residents, correct diagnosis (and therefore correct treatment) of diseases depends on a strong understanding of the molecular basis for the disease – hematologists, pathologists, oncologists, and other clinicians will benefit from this clear, focused, annotated format
Companion web site features over 900 images from the book!
Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.
Immunotherapy of Cancerprovides information on cancer research related to inflammation and immunity, containing outstanding reviews by experts in the field. It is suitable for researchers and students who have an interest in cancer immunobiology.Provides information on cancer research, including outstanding and original reviewsCovers the current progress and emerging concepts in cancer inflammation, immunology, and immunotherapy Suitable for researchers and students studying, and interested in, the field of immunotherapy for cancerIdeal for those studying cancer inflammation, tumor immunology, cancer immunotherapy, dendritic cell, antigen presentation, immune checkpoint, myeloid-derived suppressor cells, macrophages, and tumor environments
Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer.Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teamsNutritionists and dietitians will gain an understanding of cell signaling, and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods
This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research.Contents:Introduction: Why Debate Cancer, and Why Now?The Gene Mutation Theory of CancerAlternative Theories to Explain CancerThe Surprise Cancer Genome Landscape Revealed by Cancer Genome Sequencing ProjectsUnraveling the Mystery of Cancer: Understanding Genome Variation Mediated Cancer EvolutionSignificance of the Insignificant: Why "Noise" is Essential for Cancer EvolutionDo Different Cancers Represent Different Species?Facts vs. Myths
Readership: This book will be appreciated by the research community at large. It will also serve as an excellent resource for a wide range of readers, including researchers, graduate students, physicians, science reporters, and even policy-makers.
Key Features:Currently, there exists no such book. This title represents a much-needed effort to systematically re-examine many concepts in cancer research which have remained relatively the same for decadesThe topics discussed are well-known paradoxes to researchers (over 50 of them). Addressing these questions will not only provide answers to key puzzles in the field but also introduce a new conceptual framework, the genome-based cancer evolution theoryThis book will encourage new ideas/approaches that bridge basic research and clinical applications. The analysis of provocative questions will spur a long overdue debate on this subjectKeywords:Cancer Evolution;Genome Theory;Cancer Heterogeneity;Cancer Landscape;Cancer Theories;Drug Resistance;Cancer Diagnosis;Cancer Research
Cancer is not randomly distributed in the United States. Its incidence varies by race, ethnicity, socioeconomic status, and other geographic and demographic factors. This volume, co-published with the American Cancer Society, is the first to examine the biological, racial, and socioeconomic factors that influence cancer incidence and survival. In addition, it presents 15 previously unpublished, evidence-based interventions to reduce and eliminate cancer disparities.
The book explains the nature, scope, and causes of cancer disparities across different populations and then presents unique programs proven to reduce such inequalities in the areas of cancer prevention, screening and early detection, treatment, and survivorship. They represent a variety of cancers, populations, and communities across the U.S. Descriptions of each intervention include tests of effectiveness and are written in sufficient detail for readers to replicate them within their own communities.Key Features:
Offers an in-depth look at the latest research behind cancer disparitiesWritten by highly respected and published cancer researchersIncludes 15 never-before published, evidence-based interventions that readers can replicateDiscusses breast, colorectal, cervical, and other pernicious cancersIncludes interventions for African-American, Hispanic, Native American, and other populations
Written in joint collaboration by residents and staff radiation oncologists at the Department of Radiation Oncology at the Cleveland Clinic Taussig Cancer Institute, the book contains more than 900 questions addressing the full gamut of the science and practice of radiation oncology today.
Radiation Oncology Self-Assessment Guide Features: Comprehensive coverage of radiation oncologyFlash-card" format facilitates recall of key data, treatment assessment and patient management, and important original studiesOrganized by the major subject areas in radiation oncology, the question sets feature structured questions and nswers designed to test recall and sharpen skillsAuthors are from the Department of Radiation Oncology at the Cleveland Clinic Taussig Cancer Institute
Did you know that you can have breast cancer without having a lump?
Did you know that all breast cancers do not show up on a mammogram or an ultrasound?
Have you ever heard of Inflammatory Breast Cancer?
Nina Anderson, the author of this book, would have answered "no" to all of the above questions. If she had known some of these facts, she would have been more suspicious about her symptoms. She was a very health conscious individual. She had a mammogram and Pap test every year and did monthly self breast examinations. When she started having swelling, an inverted nipple, redness and a fever in her right breast, the last thing she ever suspected was that she might have breast cancer. She had hardly ever been sick in her entire life until she was diagnosed with this very aggressive and lethal form of breast cancer known as Inflammatory Breast Cancer. This book is the story of her dreadful ordeal and miraculous survival.
Nina considers the sequence of events that led to her early diagnosis a miracle that saved her life. Many women do not survive IBC because there is no lump involved and it cannot be detected by a mammogram or ultrasound. The only way to get a conclusive diagnosis is to perform a surgical biopsy of the breast and skin tissue. The symptoms of Inflammatory Breast Cancer (abbreviated as IBC) are similar to a breast infection known as mastitis. Most women are diagnosed with mastitis or cellulitis and treated with antibiotics for two to three months. By that time IBC is so aggressive that it has spread to other organs of the body and is in the final stage of breast cancer. The details of her diagnosis and the eleven months of treatment that followed are chronicled in this amazing story of survival.
During her very first chemotherapy treatment, an incident involving a bumble bee instilled a hope in Nina that would help to sustain her during the long, grueling months of treatment. She shares her experience in an effort to inform every woman about the symptoms of Inflammatory Breast Cancer and how to cope and fight the disease. It is her hope that this book will save lives. No woman should have to suffer the consequences of this disease because she has never heard of IBC or didn't know about the symptoms. Nina also wants to give every woman who is diagnosed with IBC the hope that YOU CAN SURVIVE.
Here is an excerpt from her book:
CHAPTER ONE – THE MONTH OF APRIL
RARE ENCOUNTERS OF THE INTIMATE KIND
You know how when you get past fifty years old, those intimate moments with your spouse are few and far between? Well that's kind of how it was with us. But it was one of those rare evenings when things just seemed to fall in place and it happened! Afterwards my husband, Richard, said that something wasn't right with my right breast. I told him that I had already noticed it and that I thought I might have mastitis. He had no idea what that was, so I explained that it was an infection of the mammary glands which you can sometimes have when you are breastfeeding. I had some redness and swelling and the breast had felt kind of feverish for about a week or two. I told him I guess I would have to make an appointment with my gynecologist and get some antibiotics. It was kind of aggravating to be going through menopause and have to deal with a breast infection. I promised that as much as I hated going to the doctor, I would make an appointment the next day.
When I woke up the next morning, the breast was so swollen that the nipple had inverted. I remembered when I was breast feeding that this same thing had happened when it was feeding time. The breasts would fill with milk and the right nipple would become an "inny" instead of an "outy." I would have to use a nipple shield in order for the baby to be able to nurse. So an inverted nipple with swelling was normal for me. I thought for certain that this was mastitis. I called to get an appointment with my gynecologist and, much to my disappointment; she was not practicing at this time because she had decided to stay home with her children. This was the fourth gynecologist I had had in the past four years. The last three were women and it was just my luck that every time I was ready for my next annual check up, I was informed that they were staying home with their children. I usually liked to go to a female gynecologist because I felt like a woman could understand my problems. Fortunately this time I was seeing someone who was part of a group of gynecologists so I just told the receptionist to pick one for me because I was having some problems and I needed to see someone soon. She said she would call me back to arrange the appointment.
In the meantime, I looked at my calendar and realized it was almost time for my annual mammogram, so I decided that I would try to schedule that appointment as well, especially since it usually takes about two or three weeks to get in. So I called the imaging center where I usually go to have my mammogram to see when I could come in for an appointment. The receptionist said she had an appointment open the very next day. I said, "I'll take it!" I explained to her that I thought I was having a problem. She requested that I call my gynecologist (of course I did not know who that would be at this time) and request an order for a "diagnostic mammogram." She said to tell them to fax it to them so they would be able to do a more extensive mammogram when I came in the next day. So I called the gynecologist group's office and discovered I had been assigned a new doctor and I asked if it would be possible for them to fax a request for the diagnostic mammogram and of course they were able to do this. My appointment with the gynecologist would be in July. This was April 4th.
So on April 5th, 2002, at 2:00 PM I went to have my annual mammogram at the same place I had been going for the past five years. The technician was very nice and she had gotten the fax of the order for the diagnostic tests. I went through the usual eye popping experience only this time it seemed a little more uncomfortable. I waited for the nurse to come back to tell me if the images were OK before getting dressed. When she came in, she said that the radiologist would like to see me. As I was getting dressed, I was thinking that I didn't remember this ever happening before. Maybe they have changed the procedure. When I walked into the slightly darkened room, the radiologist had several x-rays on a lighted background. He began to focus in on an area on my right breast that he said was positioned at about 5 o'clock that indicated there might be a problem. He talked about two types of problems, non-malignant and malignant. I don't remember everything that was said but I do remember the part where he said that he thought that I had a malignant tumor and that the survival rate dropped depending on the size of the tumor. I asked him to explain what he meant. He said with 1 centimeter it is about 90% survival, 1.5 it drops to 80% and so on. I wanted to say, "Are you talking to me?" I have mastitis; I don't have malignant breast cancer! You must have the wrong x-rays up there! But I didn't say anything. The radiologist suggested that we try to get a better image with an ultrasound, so the ultrasound technician escorted me to the ultrasound room where once again I undressed. She tried for 45 minutes to pick up an image but was unsuccessful. I felt certain by now that they had the wrong person and the wrong x-rays. So I got dressed again and the radiologist came in and said that even though the technician could not get an image that did not matter. He advised me that I should go straight to a surgeon and just skip the biopsy. He sai
Edited by Mukesh G. Harisinghani, MD, with chapter contributions from staff members of the Department of Radiology at Massachusetts General Hospital.
Since its discovery in 1953 by Watson and Crick, the DNA double helix has been thought of as the language of God. From that point on, throughout the ensuing decades, research has decoded much of that language, giving scientists a more respectable insight into the paradox of life itself. Now, furthering that insight, Dr. Luksas has determined a means of using that language to address cancer and perhaps other diseases.
Providing a wealth of information on DNA and how it functions in the body, as well as other processes important to the replication of cancerous bodies such as cell respiration and metastasis, Dr. Luksas explains his findings with the common reader in mind.
Everything seemed to go on as usual, but nothing was normal anymore. I wanted to shout at everyone, “Don’t you see life has changed? It will never be the same again?”
After surgery, I opted for prosthetics and early on was using the fiber-filled breasts. There was only one problem, and it was major! These things were too light. They kept moving up my body and hitting my chin. This was not going to work.
Rather than being a side-by-side collection of articles, this book consists of related chapters. It is a common achievement by 76 experts from around the world. Their expertise reflects the diversity of the field with radiation therapy, medical and accelerator physics, radiobiology, computer science, engineering, and health economics. The book addresses a similarly broad audience ranging from professionals that need to know more about this novel treatment modality or consider to enter the field of ion beam therapy as a researcher. However, it is also written for the interested public and for patients who might want to learn about this treatment option.
The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer.
* Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer
* Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination
* Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance
The first main part of the book is subdivided into blood banking and transfusion medicine. Under blood banking, the chapters cover blood collection, donation process, component manufacturing, donor testing and storage; transfusion-medicine chapters examine the components for transfusion, pre-transfusion immunohematology testing, blood groups, blood products and their modifications, approaches to transfusion therapy in specific clinical settings, and transfusion reactions and complications. In addition, chapters that talk about apheresis, cellular therapy, and tissue banking in the hospital setting are included.
Hemostasis, the second main part of the book, is subdivided into three sections. The first section, clinical coagulation, includes chapters about neonatal thrombocytopenia, inherited platelet function disorders, immune thrombocytopenia, immune-mediated coagulopathies, congenital bleeding disorders, and acquired bleeding disorders. The second section relates to laboratory testing of coagulation, with chapters about laboratory assessments of platelet disorders, von Willebrand disease, coagulation factor disorders, fibrinogen and fibrinolysis, tests for hypercoagulable state and for activation of the coagulation system, and laboratory support for anticoagulation. The third section discusses coagulation factor products.
This book will be valuable for the education of trainees, practitioners, and future leaders in these fields.
Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers.
With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.