This Brief provides the basic knowledge regarding Trisomy 21 diseases and its existing detection methods. The restrictions and disadvantages of each method are discussed accordingly. Therefore, a non-invasive early detection method using 3D ultrasound reconstruction of Nuchal Translucency is introduced. This new method for 3D NT assessments has an edge over the previous 2D methods, and entails the composite function in visualizing the explicit internal marker structure. Further, image processing techniques covered from data acquisition, pre-processing, speckle noise reduction and 3D segmentation are also discussed. This should be especially useful for students and professional researchers in the Biomedical and image processing fields.
There are many biochemistry textbooks in the market. Some of them are purely basic while others are applied, and there are very few books which cover both these aspects together. For this reason, the students learning biochemistry in their undergraduate courses have to depend on multiple books to acquire a sound knowledge of the subject.
This book, ‘Biochemistry’ is unique with a simultaneous and equal emphasis on basic and applied aspects of biochemistry. This textbook offers an integration of medical and pure sciences, comprehensively written to meet the curriculum requirements of undergraduate courses in medical, dental, pharmacy, life-sciences and other categories (agriculture, veterinary, etc.).
This book is designed to develop in students a sustained interest and enthusiasm to learn and develop the concepts in biochemistry in a logical and stepwise manner. It incorporates a variety of pedagogic aids, besides colour illustrations to help the students understand the subject quickly and to the maximum. The summary and biomedical/clinical concepts are intended for a rapid absorption and assimilation of the facts and concepts in biochemistry. The self-assessment exercises will stimulate the students to think rather than merely learn the subject. In addition, these exercises (essays, short notes, fill in the blanks, multiple choice questions) set at different difficulty levels, will cater to the needs of all the categories of learners.
New to This Edition
The book offers an integration of medical and pure sciences, and is comprehensively written, revised and updated to meet the curriculum requirements of Medical, Pharmacy, Dental, Veterinary, Biotechnology, Agricultural Sciences, Life Sciences, and others studying Biochemistry as one of the subjects.
It is the first text book on Biochemistry in English with multi-colour illustrations by an author from Asia. The use of multicolours is for a clearer understanding of the complicated biochemical reactions.
It is written in a lucid style with the subject being presented as an engaging story growing from elementary information to the most recent advances, and with theoretical discussions being supplemented with illustrations, flowcharts, and tables for easy understanding of Biochemistry.
It has each chapter beginning with a four-line verse followed by the text, biomedical concepts, a summary, and self-assessment exercises. The lively illustrations and text with appropriate headings and sub-headings in bold type faces facilitate reading path clarity and quick recall.
It provides the most recent and essential information on Molecular Biology and Biotechnology, Diabetes, Cancer, Free Radicals, Free radicals and Antioxidants, Prostaglandins, etc.
It describes a wide variety of case studies and biochemical correlations and several newer biomedical aspects- Metabolic syndrome, Therapeutic diets, Atkins diet, Trans fatty acids, Epigenetics, Nutrigenomics, Recombinant ribozymes, Membrane transport disorders, Pleural fluid etc.
It contains the basics (Bioorganic and Biophysical Chemistry, Tools of Biochemistry, Immunology, and Genetics) for beginners to learn easily Biochemistry, origins of biochemical words, confusables in Biochemistry, principles of Practical Biochemistry, and Clinical Biochemistry Laboratory.
Timeless and collectible, the lectures are essential reading, not just for students of physics but for anyone seeking an introduction to the field from the inimitable Feynman.
Imaging Informatics Professionals (IIPs) have come to play an indispensable role in modern medicine, and the scope of this profession has grown far beyond the boundaries of the PACS. A successful IIP must not only understand the PACS itself, but also have knowledge of clinical workflow, a base in several medical specialties, and a solid IT capability regarding software interactions and networking. With the introduction of a certification test for the IIP position, a single source was needed to explain the fundamentals of imaging informatics and to demonstrate how those fundamentals are applied in everyday practice. Practical Imaging Informatics describes the foundations of information technology and clinical image management, details typical daily operations, and discusses rarer complications and issues.
A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging.
Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach.
In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.
Each chapter ends with clinical cases and the related questions, which evokes yet another method of active learning rather than didactic methods of imparting knowledge.
Key points have been highlighted and boxed at the end of each topic for quick revision of the core concepts.
This book comes with a free companion website which contains self-assessment exercises, detailed case discussions related to the clinical cases given inside the book, glossary and various other features for enhanced learning.
This edition includes greatly expanded focus on stem cells, including adult and embryonic stem cells and progenitor populations that may soon lead to new tissue engineering therapies for heart disease, diabetes, and a wide variety of other diseases that afflict humanity. This up-to-date coverage of stem cell biology and other emerging technologies is complemented by a series of new chapters on recent clinical experience in applying tissue engineering. The result is a comprehensive textbook that we believe will be useful to students and experts alike.
New to this edition:
*Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves
*Expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems
Life is the most extraordinary phenomenon in the known universe; but how did it come to be? Even in an age of cloning and artificial biology, the remarkable truth remains: nobody has ever made anything living entirely out of dead material. Life remains the only way to make life. Are we still missing a vital ingredient in its creation?
Like Richard Dawkins' The Selfish Gene, which provided a new perspective on how evolution works, Life on the Edge alters our understanding of our world's fundamental dynamics. Bringing together first-hand experience at the cutting edge of science with unparalleled gifts of explanation, Jim Al-Khalili and Johnjoe Macfadden reveal that missing ingredient to be quantum mechanics; the phenomena that lie at the heart of this most mysterious of sciences.
Drawing on recent ground-breaking experiments around the world, each chapter in Life on the Edge engages by illustrating one of life's puzzles: How do migrating birds know where to go? How do we really smell the scent of a rose? How do our genes copy themselves with such precision? Life on the Edge accessibly reveals how quantum mechanics can answer these probing questions of the universe.
Guiding the reader through the rapidly unfolding discoveries of the last few years, Al-Khalili and McFadden communicate the excitement of the explosive new field of quantum biology and its potentially revolutionary applications, while offering insights into the biggest puzzle of all: what is life? As they brilliantly demonstrate in these groundbreaking pages, life exists on the quantum edge.
– Winner, Stephen Hawking Medal for Science Communication
This inspiring guide shows you how to use Arduino to create gadgets for measuring noise, weather, electromagnetic interference (EMI), water purity, and more. You’ll also learn how to collect and share your own data, and you can experiment by creating your own variations of the gadgets covered in the book. If you’re new to DIY electronics, the first chapter offers a primer on electronic circuits and Arduino programming.Use a special microphone and amplifier to build a reliable noise monitor Create a gadget to detect energy vampires: devices that use electricity when they’re “off” Examine water purity with a water conductivity device Measure weather basics such as temperature, humidity, and dew point Build your own Geiger counter to gauge background radiation Extend Arduino with an Ethernet shield—and put your data on the Internet Share your weather and radiation data online through Pachube
THE BEST REVIEW FOR THE USMLE!
The Thirtieth Edition of Harper’s Illustrated Biochemistry combines outstanding full-color illustrations with authoritative integrated coverage of biochemical disease and clinical information. Using brevity and numerous medically relevant examples, Harper's presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school.
All fifty-eight chapters emphasize the medical relevance of biochemistryFull-color presentation includes more than 600 illustrations Each chapter includes a section on Biomedical Importance and a summary of the topics covered Review questions follow each of the eleven sections Case studies in every chapter emphasize the clinical relevance to biochemistry NEW coverage of toxic naturally-occurring amino acids; extraterrestrial biomolecules; computer-aided drug design; the role of complement cascade in bacterial and viral infection; secreted mediators of cell-cell signaling between leukocytes; the role of mast cells, basophils, and eosinophils; and the hazard of antioxidants that down-regulate radical signaling for apoptosis and increase risk of cancer
Applauded by medical students for its current and engaging style, Harper's Illustrated Biochemistry is an essential for USMLE review and the single best reference for learning the clinical relevance of any biochemistry topic.
The Olympics are the world's most prestigious stage for athletic competition. Fans both casual and hardcore tune in religiously every few years to watch as men and women push themselves to the limits of human performance. But what makes a champion? Is it genetics? Hours of training? A psychological advantage? Of all the athletes who dedicate their lives - and bodies - to achieving that perfect moment of triumph, why will one person or team win out over another? Science has some compelling answers, and in this book, The Science of Sports: Winning in the Olympics, Scientific American explores this topic from various angles. Beginning with Section 1: The Psychology of Winning, the book opens with a look inside the mind of an elite athlete and tackles questions of how to face a rivalry or maintain a positive attitude in the face of defeat. Other sections discuss the sticky issues surrounding genetic advantages and physical prowess, drugs and doping, injury and recovery, and - finally - the latest scientific advice for the rest of us mere mortals to be fit and healthy. You'll find both inspiration and answers in this indispensable book from the editors of Scientific American, the leading authority on science, technology and innovation.
This new edition discusses biological systems that can be analyzed quantitatively, and how advances in the life sciences have been aided by the knowledge of physical or engineering analysis techniques. The volume is organized into 18 chapters encompassing thermodynamics, electricity, optics, sound, solid mechanics, fluid mechanics, and atomic and nuclear physics. Each chapter provides a brief review of the background physics before focusing on the applications of physics to biology and medicine. Topics range from the role of diffusion in the functioning of cells to the effect of surface tension on the growth of plants in soil and the conduction of impulses along the nervous system. Each section contains problems that explore and expand some of the concepts. The text includes many figures, examples and illustrative problems and appendices which provide convenient access to the most important concepts of mechanics, electricity, and optics in the body.
Physics in Biology and Medicine will be a valuable resource for students and professors of physics, biology, and medicine, as well as for applied health workers.Provides practical techniques for applying knowledge of physics to the study of living systemsPresents material in a straight forward manner requiring very little background in physics or biologyIncludes many figures, examples and illustrative problems and appendices which provide convenient access to the most important concepts of mechanics, electricity, and optics in the body
Detect harmful gases, dust particles such as smoke and smog, and upper atmospheric haze—substances and conditions that are often invisible to your senses. You’ll also discover how to use the scientific method to help you learn even more from your atmospheric tests.Get up to speed on Arduino with a quick electronics primer Build a tropospheric gas sensor to detect carbon monoxide, LPG, butane, methane, benzene, and many other gases Create an LED Photometer to measure how much of the sun’s blue, green, and red light waves are penetrating the atmosphere Build an LED sensitivity detector—and discover which light wavelengths each LED in your Photometer is receptive to Learn how measuring light wavelengths lets you determine the amount of water vapor, ozone, and other substances in the atmosphere Upload your data to Cosm and share it with others via the Internet
"The future will rely on citizen scientists collecting and analyzing their own data. The easy and fun gadgets in this book show everyone from Arduino beginners to experienced Makers how best to do that."
--Chris Anderson, Editor in Chief of Wired magazine, author of Makers: The New Industrial Revolution (Crown Business)
After providing the fundamentals for ISAR imaging, the book gives the detailed imaging procedures for ISAR imaging with associated MATLAB functions and codes. To enhance the image quality in ISAR imaging, several imaging tricks and fine-tuning procedures such as zero-padding and windowing are also presented. Finally, various real applications of ISAR imagery, like imaging the antenna-platform scattering, are given in a separate chapter. For all these algorithms, MATLAB codes and figures are included. The final chapter considers advanced concepts and trends in ISAR imaging.
Eve Herold's Beyond Human examines the medical technologies taking shape at the nexus of computing, microelectronics, engineering, nanotechnology, cellular and gene therapies, and robotics. These technologies will dramatically transform our lives and allow us to live for hundreds of years. Yet, with these blessings come complicated practical and ethical issues, some of which we can predict, but many we cannot.
Beyond Human taps the minds of doctors, scientists, and engineers engaged in developing a host of new technologies while telling the stories of some of the patients courageously testing the radical new treatments about to come into the market.
Beyond Human asks the difficult questions of the scientists and bioethicists who seek to ensure that as our bodies and brains become ever more artificial, we hold onto our humanity. In this new world, will everyone have access to technological miracles, or will we end up living in a world of radical disparities? How will society accommodate life spans that extend into hundreds of years? Will we and our descendants be able to bring about the dream of a future liberated by technology, or will we end up merely serving the machines and devices that keep us healthy, smart, young, and alive?
Interested in unraveling the physics of living things? Here's your starting point. Biophysics Demystified is the fast and easy way to understand this fascinating topic.
Written in a step-by-step format, this practical guide begins with an introduction to the science of biophysics, covering biophysical techniques and applications. Next, you'll learn the principles of physics, biology, and chemistry required to understand biophysics, including free energy, entropy, and statistical mechanics. Biomolecules and the forces that influence their structure and conformation are also covered, as are protein, nucleic acid, and membrane biophysics. Detailed examples and concise explanations make it easy to understand the material, and end-of-chapter quizzes and a final exam help reinforce key concepts.
It's a no-brainer! You'll get:Molecular, subcellular, physiological, anatomical, and environmental biophysics The laws of thermodynamics as they apply to biophysical systems Forces affecting conformation in biological molecules The composition and structure of carbohydrates, lipids, proteins, and nucleic acids The fluid mosaic model
Simple enough for a beginner, but challenging enough for an advanced student, Biophysics Demystified makes this interdisciplinary subject easy to master.
One of the most diverse of modern scientific disciplines, biophysics applies methods and technologies from physics to the study of biological systems and phenomena, from the human nervous system to soil erosion to global warming. What are the best options for satisfying the world's growing energy demands? How can we feed the world's growing population? How can we contain, or reverse, global warming? How can we vouchsafe a plentiful supply of potable water for future generations? These are among the critical questions to which biophysicists work to provide answers.Biophysics courses are increasingly taken by students of biology, physics, chemistry, biochemistry, physiology, statistics, bioengineering, neuroscience, computer science, pharmacology, agriculture,and many more Provides a friendly, unintimidating overview of the material covered in a typical college-level biophysics course A one-stop reference, course supplement and exam preparation tool for university students currently enrolled in an introductory biophysics courses An indispensable resource for those studying the natural sciences, biological sciences, and physics, as well as math, statistics,computer science, pharmacology and many other disciplines The current job market for people well versed in biophysics is very strong, and biophysics is currently listed as one of the fast-growing occupations in the North America
As fields like communications, speech and image processing, and related areas are rapidly developing, the FFT as one of the essential parts in digital signal processing has been widely used. Thus there is a pressing need from instructors and students for a book dealing with the latest FFT topics.
Fast Fourier Transform - Algorithms and Applications provides a thorough and detailed explanation of important or up-to-date FFTs. It also has adopted modern approaches like MATLAB examples and projects for better understanding of diverse FFTs.
Fast Fourier Transform - Algorithms and Applications is designed for senior undergraduate and graduate students, faculty, engineers, and scientists in the field, and self-learners to understand FFTs and directly apply them to their fields, efficiently. It is designed to be both a text and a reference. Thus examples, projects and problems all tied with MATLAB, are provided for grasping the concepts concretely. It also includes references to books and review papers and lists of applications, hardware/software, and useful websites. By including many figures, tables, bock diagrams and graphs, this book helps the reader understand the concepts of fast algorithms readily and intuitively. It provides new MATLAB functions and MATLAB source codes. The material in Fast Fourier Transform - Algorithms and Applications is presented without assuming any prior knowledge of FFT. This book is for any professional who wants to have a basic understanding of the latest developments in and applications of FFT. It provides a good reference for any engineer planning to work in this field, either in basic implementation or in research and development.
The handbook begins with a series of historical vignettes of pioneers from the last two centuries. It also presents the fundamentals of physics and biology as applied to photomedicine. It next examines conditions and diseases caused by light, including skin cancer, dermatoses, and immunosuppression.
The remainder of the book focuses on the most important clinical therapeutic applications of different kinds of light that vary in both wavelength and intensity. The book discusses ultraviolet phototherapy for skin diseases and infections and presents the basic science of photodynamic therapy and its use in cancer therapy and other medical specialties. It then covers mechanistic studies and clinical applications of low-level laser (light) therapy as well as the use of high power or surgical laser therapy in specialties, such as dentistry and dermatology. The book concludes with a collection of miscellaneous types of phototherapy.
This important guide/reference presents a comprehensive overview of medical image analysis. Highly practical in its approach, the text is uniquely structured by potential applications, supported by exercises throughout. Each of the key concepts are introduced in a concise manner, allowing the reader to understand the interdependencies between them before exploring the deeper details and derivations.
Topics and features: presents learning objectives, exercises and concluding remarks in each chapter, in addition to a glossary of abbreviations; describes a range of common imaging techniques, reconstruction techniques and image artefacts; discusses the archival and transfer of images, including the HL7 and DICOM standards; presents a selection of techniques for the enhancement of contrast and edges, for noise reduction and for edge-preserving smoothing; examines various feature detection and segmentation techniques, together with methods for computing a registration or normalisation transformation; explores object detection, as well as classification based on segment attributes such as shape and appearance; reviews the validation of an analysis method; includes appendices on Markov random field optimization, variational calculus and principal component analysis.
This easy-to-follow, classroom-tested textbook is ideal for undergraduate and graduate courses on medical image analysis and related subjects – with possible course outlines suggested in the Preface. The work can also be used as a self-study guide for professionals in medical imaging technology, and for computer scientists and engineers wishing to specialise in medical applications.
Filling the void, Biotechnology Operations: Principles and Practices reflects this integrative philosophy, serving as a practical guide for students, professionals, or anyone else with interests in the biotech industry. Although many books emphasize specific technical aspects of biotech, this is perhaps the first to integrate essential concepts of product development and scientific and management skills with the seven functional areas of biotechnology:
Biomanufacturing Clinical trials Nonclinical studies Project management Quality assurance Quality control Regulatory affairs
A practical roadmap to optimizing biotechnology operations, this reference illustrates how to use specific product planning, design, and project management processes to seamlessly merge plans and efforts in the key functional areas. Applying lessons learned throughout the nascent history of biotech, author Michael Roy highlights developmental principles that could bring future products to market more safely and efficiently. Drawing from his experiences working in industry and teaching a graduate course at the University of Wisconsin, this hotly anticipated book clarifies basic methodologies and practices to help reduce risks and resolve problems as future technological discoveries are developed into tangible products.
Detailed calculation steps, useful comments, and mathematical hints enhance solved problems throughout...
Encouraging the use of the Ratio Method, the author draws attention to its applicability to a wide variety of biochemistry problems with logical consistency and intuitive ease. This entirely revised and updated second edition introduces three new chapters with coverage of laboratory-oriented calculations and data presentation, calculations relating to the emerging techniques in DNA and molecular biology, and applying the Ratio Method to pharmaceutical calculations.
New edition adds questions and extra tips in every chapter to help students perform biochemical calculations on their own!
By strengthening their understanding of mathematical logic and problem solving skills, Fundamentals of Biochemical Calculations, Second Edition enables students and biochemists to explore a wider range of real-world applications with the ability to tackle increasingly complex problems in biochemistry and related fields.
This technique-specific book is primarily of benefit to those in training in general radiology and more specifically for Residents and Fellows who are training in interventional radiology and who may be taking subspeciality certificate examinations in interventional radiology. In addition, this book will be of help to most practicing interventional radiologists, be they be in academic or private practice. This is the kind of book that can be left in the interventional lab and will be of benefit to ancillary staff, such as technicians/radiographers or nurses who are specialising in the care of patients referred to interventional radiology.
This volume on neurointervention will enhance the series by expounding on the specific techniques required when working on conditions of the head, neck and spine.
The main thrust of the material is analog circuitry, focusing on fundamental principles of transistors, integrated circuit and vacuum tube-based amplifier operation and theory, and operation of typical guitar signal processing effects circuits. Updated to the new edition include:
• New coverage of tone control circuits, MOSFETS and their applications as small-signal amplifiers, rail splitters and charge pumps, amplifiers using germanium transistors, and tube power amp design
• Expanded coverage of numerous subjects such as vacuum tube power supplies, the digital oscilloscope, Darlington and Sziklai transistors, and signal spectra and transfer function symmetry
• Additional examples of various circuits such as overdrive, distortion, chorus, delay, tremolo and auto-wah circuits as well as amplifier design
Electronics for Guitarists is ideal for the musician or engineer interested in analog signal processing. The material is also useful to general electronics hobbyists, technologists and engineers with an interest in guitar and music-related electronics applications.
Get a thorough review of ultrasound vascular diagnosis, including peripheral veins and arteries, carotid and vertebral arteries, abdominal vessels, and transcranial Doppler.
Quickly reference numerous tables for examination protocols, normal values, diagnostic parameters, and ultrasound findings for selected conditions.
Visualize important techniques with hundreds of lavish line drawings and clinical ultrasound examples.Stay current with trending topics through new chapters on evaluation of organ transplants, screening for vascular disease, correlative imaging, and accreditation and the vascular lab.
Experience clinical scenarios with vivid clarity through new color ultrasound images.
Watch vascular ultrasound videos and access the complete contents online at www.expertconsult.com.
Benefit from the fresh perspective and insight of a new co-editor, Dr. Joseph Polak.
Improve your understanding of the correlation of imaging results with treatment goals in venous and arterial disease.
Learn the principles of vascular ultrasonography from the most trusted reference in the field.
The new edition includes: modifications to about 30-40% of the end of chapter problems; a new introduction to electromagnetics based on behavior of charges; a new section on units; MATLAB tools for solution of problems and demonstration of subjects; most chapters include a summary. The book is an undergraduate textbook at the Junior level, intended for required classes in electromagnetics. It is written in simple terms with all details of derivations included and all steps in solutions listed. It requires little beyond basic calculus and can be used for self-study. The wealth of examples and alternative explanations makes it very approachable by students.
· More than 400 examples and exercises, exercising every topic in the book
· · Includes 600 end-of-chapter problems, many of them applications or simplified applications
· · Discusses the finite element, finite difference and method of moments in a dedicated chapter
Additional highlights include:
- Fundamental information on communications, signal and system theories
- Coverage of superheterodyne, direct-conversion, low-IF, and band-pass sampling radio architectures
- Frequency planning, system link budgeting, and performance evaluation of transmitters and receivers
- Nonlinearity effect analyses involving intermodulation, interferer blocking, spectrum regrowth and modulation
- Approaches for specifying RF ASICs on which mobile systems are built
- AGC systems, ADC dynamic range consideration and power management are addressed
- In-depth treatment of both theoretical and practical aspects of mobile station RF system design
This comprehensive reference work covers a wide range of topics from general principles of communication theory, as it applies to digital radio designs to specific examples on implementing multimode mobile systems. Wireless engineering professionals will definitely find this an invaluable reference book.