This volume provides formulas and procedures for determination of sample size required not only for testing equality, but also for testing non-inferiority/superiority, and equivalence (similarity) based on both untransformed (raw) data and log-transformed data under a parallel-group design or a crossover design with equal or unequal ratio of treatment allocations. It contains a comprehensive and unified presentation of statistical procedures for sample size calculation that are commonly employed at various phases of clinical development. Each chapter includes, whenever possible, real examples of clinical studies from therapeutic areas such as cardiovascular, central nervous system, anti-infective, oncology, and women's health to demonstrate the clinical and statistical concepts, interpretations, and their relationships and interactions.
The book highlights statistical procedures for sample size calculation and justification that are commonly employed in clinical research and development. It provides clear, illustrated explanations of how the derived formulas and/or statistical procedures can be used.
#1 NEW YORK TIMES BESTSELLER
Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor black tobacco farmer whose cells—taken without her knowledge in 1951—became one of the most important tools in medicine, vital for developing the polio vaccine, cloning, gene mapping, and more. Henrietta's cells have been bought and sold by the billions, yet she remains virtually unknown, and her family can't afford health insurance. This phenomenal New York Times bestseller tells a riveting story of the collision between ethics, race, and medicine; of scientific discovery and faith healing; and of a daughter consumed with questions about the mother she never knew.
In the current debate about creationism and intelligent design, there is an element of the controversy that is rarely mentioned-the evidence. Yet the proof of evolution by natural selection is vast, varied, and magnificent. In this succinct and accessible summary of the facts supporting the theory of natural selection, Jerry A. Coyne dispels common misunderstandings and fears about evolution and clearly confirms the scientific truth that supports this amazing process of change. Weaving together the many threads of modern work in genetics, paleontology, geology, molecular biology, and anatomy that demonstrate the "indelible stamp" of the processes first proposed by Darwin, Why Evolution Is True does not aim to prove creationism wrong. Rather, by using irrefutable evidence, it sets out to prove evolution right.
"Intelligent Design" is being taught in our schools; educators are being asked to "teach the controversy" behind evolutionary theory. There is no controversy. Dawkins sifts through rich layers of scientific evidence—from living examples of natural selection to clues in the fossil record; from natural clocks that mark the vast epochs wherein evolution ran its course to the intricacies of developing embryos; from plate tectonics to molecular genetics—to make the airtight case that "we find ourselves perched on one tiny twig in the midst of a blossoming and flourishing tree of life and it is no accident, but the direct consequence of evolution by non-random selection." His unjaded passion for the natural world turns what might have been a negative argument, exposing the absurdities of the creationist position, into a positive offering to the reader: nothing less than a master’s vision of life, in all its splendor.
New York Times Bestseller
“Not so different in spirit from the way public intellectuals like John Kenneth Galbraith once shaped discussions of economic policy and public figures like Walter Cronkite helped sway opinion on the Vietnam War…could turn out to be one of the more momentous books of the decade.”
—New York Times Book Review
"Nate Silver's The Signal and the Noise is The Soul of a New Machine for the 21st century."
—Rachel Maddow, author of Drift
"A serious treatise about the craft of prediction—without academic mathematics—cheerily aimed at lay readers. Silver's coverage is polymathic, ranging from poker and earthquakes to climate change and terrorism."
—New York Review of Books
Nate Silver built an innovative system for predicting baseball performance, predicted the 2008 election within a hair’s breadth, and became a national sensation as a blogger—all by the time he was thirty. He solidified his standing as the nation's foremost political forecaster with his near perfect prediction of the 2012 election. Silver is the founder and editor in chief of the website FiveThirtyEight.
Drawing on his own groundbreaking work, Silver examines the world of prediction, investigating how we can distinguish a true signal from a universe of noisy data. Most predictions fail, often at great cost to society, because most of us have a poor understanding of probability and uncertainty. Both experts and laypeople mistake more confident predictions for more accurate ones. But overconfidence is often the reason for failure. If our appreciation of uncertainty improves, our predictions can get better too. This is the “prediction paradox”: The more humility we have about our ability to make predictions, the more successful we can be in planning for the future.
In keeping with his own aim to seek truth from data, Silver visits the most successful forecasters in a range of areas, from hurricanes to baseball, from the poker table to the stock market, from Capitol Hill to the NBA. He explains and evaluates how these forecasters think and what bonds they share. What lies behind their success? Are they good—or just lucky? What patterns have they unraveled? And are their forecasts really right? He explores unanticipated commonalities and exposes unexpected juxtapositions. And sometimes, it is not so much how good a prediction is in an absolute sense that matters but how good it is relative to the competition. In other cases, prediction is still a very rudimentary—and dangerous—science.
Silver observes that the most accurate forecasters tend to have a superior command of probability, and they tend to be both humble and hardworking. They distinguish the predictable from the unpredictable, and they notice a thousand little details that lead them closer to the truth. Because of their appreciation of probability, they can distinguish the signal from the noise.
With everything from the health of the global economy to our ability to fight terrorism dependent on the quality of our predictions, Nate Silver’s insights are an essential read.
In The Disappearing Spoon, bestselling author Sam Kean unlocked the mysteries of the periodic table. In THE VIOLINIST'S THUMB, he explores the wonders of the magical building block of life: DNA.
There are genes to explain crazy cat ladies, why other people have no fingerprints, and why some people survive nuclear bombs. Genes illuminate everything from JFK's bronze skin (it wasn't a tan) to Einstein's genius. They prove that Neanderthals and humans bred thousands of years more recently than any of us would feel comfortable thinking. They can even allow some people, because of the exceptional flexibility of their thumbs and fingers, to become truly singular violinists.
Kean's vibrant storytelling once again makes science entertaining, explaining human history and whimsy while showing how DNA will influence our species' future.
It took Charles Darwin more than twenty years to publish this book, in part because he realized that it would ignite a firestorm of controversy. On the Origin of Species first appeared in 1859, and it remains a continuing source of conflict to this day. Even among those who reject its ideas, however, the work's impact is undeniable. In science, philosophy, and theology, this is a book that changed the world.
In addition to its status as the focus of a dramatic turning point in scientific thought, On the Origin of Species stands as a remarkably readable study. Carefully reasoned and well-documented in its arguments, the work offers coherent views of natural selection, adaptation, the struggle for existence, survival of the fittest, and other concepts that form the foundation of modern evolutionary theory. This volume is a reprint of the critically acclaimed first edition.
“Rich in dexterous innuendo, laugh-out-loud humor and illuminating fact. It’s compulsively readable.” —Los Angeles Times Book Review In ?Bonk, ?the best-selling author of Stiff turns her outrageous curiosity and insight on the most alluring scientific subject of all: sex. Can a person think herself to orgasm? Why doesn't Viagra help women-or, for that matter, pandas? Can a dead man get an erection? Is vaginal orgasm a myth? Mary Roach shows us how and why sexual arousal and orgasm-two of the most complex, delightful, and amazing scientific phenomena on earth-can be so hard to achieve and what science is doing to make the bedroom a more satisfying place.
For those who slept through Stats 101, this book is a lifesaver. Wheelan strips away the arcane and technical details and focuses on the underlying intuition that drives statistical analysis. He clarifies key concepts such as inference, correlation, and regression analysis, reveals how biased or careless parties can manipulate or misrepresent data, and shows us how brilliant and creative researchers are exploiting the valuable data from natural experiments to tackle thorny questions.
And in Wheelan’s trademark style, there’s not a dull page in sight. You’ll encounter clever Schlitz Beer marketers leveraging basic probability, an International Sausage Festival illuminating the tenets of the central limit theorem, and a head-scratching choice from the famous game show Let’s Make a Deal—and you’ll come away with insights each time. With the wit, accessibility, and sheer fun that turned Naked Economics into a bestseller, Wheelan defies the odds yet again by bringing another essential, formerly unglamorous discipline to life.
These may not sound like typical questions for an economist to ask. But Steven D. Levitt is not a typical economist. He is a much-heralded scholar who studies the riddles of everyday life—from cheating and crime to sports and child-rearing—and whose conclusions turn conventional wisdom on its head.
Freakonomics is a groundbreaking collaboration between Levitt and Stephen J. Dubner, an award-winning author and journalist. They usually begin with a mountain of data and a simple question. Some of these questions concern life-and-death issues; others have an admittedly freakish quality. Thus the new field of study contained in this book: Freakonomics.
Through forceful storytelling and wry insight, Levitt and Dubner show that economics is, at root, the study of incentives—how people get what they want, or need, especially when other people want or need the same thing. In Freakonomics, they explore the hidden side of . . . well, everything. The inner workings of a crack gang. The truth about real-estate agents. The myths of campaign finance. The telltale marks of a cheating schoolteacher. The secrets of the Ku Klux Klan.
What unites all these stories is a belief that the modern world, despite a great deal of complexity and downright deceit, is not impenetrable, is not unknowable, and—if the right questions are asked—is even more intriguing than we think. All it takes is a new way of looking.
Freakonomics establishes this unconventional premise: If morality represents how we would like the world to work, then economics represents how it actually does work. It is true that readers of this book will be armed with enough riddles and stories to last a thousand cocktail parties. But Freakonomics can provide more than that. It will literally redefine the way we view the modern world.
Bonus material added to the revised and expanded 2006 editionThe original New York Times Magazine article about Steven D. Levitt by Stephen J. Dubner, which led to the creation of this book.Seven “Freakonomics” columns written for the New York Times Magazine, published between August 2005 and April 2006.Selected entries from the Freakonomics blog, posted between April 2005 and May 2006 at http://www.freakonomics.com/blog/.
The Tenth Edition of Australian CAMPBELL BIOLOGY helps launch students to success in biology through its clear and engaging narrative, superior pedagogy, and innovative use of art and photos to promote student learning. It continues to engage students with its dynamic coverage of the essential elements of this critical discipline. This Tenth Edition, with an increased focus on evolution, ensures students receive the most up-to-date, accurate and relevant information.
Named one of the top books of 2009 by the Times Literary Supplement (London), this controversial and compelling book from Dr. Stephen C. Meyer presents a convincing new case for intelligent design (ID), based on revolutionary discoveries in science and DNA. Along the way, Meyer argues that Charles Darwin’s theory of evolution as expounded in The Origin of Species did not, in fact, refute ID. If you enjoyed Francis Collins’s The Language of God, you’ll find much to ponder—about evolution, DNA, and intelligent design—in Signature in the Cell.
Tracing one scientist's journey toward understanding the crucial importance of the microbiome, this revolutionary book will take readers to the forefront of trail-blazing research while revealing the damage that overuse of antibiotics is doing to our health: contributing to the rise of obesity, asthma, diabetes, and certain forms of cancer. In Missing Microbes, Dr. Martin Blaser invites us into the wilds of the human microbiome where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now, this invisible eden is being irrevocably damaged by some of our most revered medical advances—antibiotics—threatening the extinction of our irreplaceable microbes with terrible health consequences. Taking us into both the lab and deep into the fields where these troubling effects can be witnessed firsthand, Blaser not only provides cutting edge evidence for the adverse effects of antibiotics, he tells us what we can do to avoid even more catastrophic health problems in the future.
The Earth teems with life: in its oceans, forests, skies and cities. Yet there’s a black hole at the heart of biology. We do not know why complex life is the way it is, or, for that matter, how life first began. In The Vital Question, award-winning author and biochemist Nick Lane radically reframes evolutionary history, putting forward a solution to conundrums that have puzzled generations of scientists.
For two and a half billion years, from the very origins of life, single-celled organisms such as bacteria evolved without changing their basic form. Then, on just one occasion in four billion years, they made the jump to complexity. All complex life, from mushrooms to man, shares puzzling features, such as sex, which are unknown in bacteria. How and why did this radical transformation happen?
The answer, Lane argues, lies in energy: all life on Earth lives off a voltage with the strength of a lightning bolt. Building on the pillars of evolutionary theory, Lane’s hypothesis draws on cutting-edge research into the link between energy and cell biology, in order to deliver a compelling account of evolution from the very origins of life to the emergence of multicellular organisms, while offering deep insights into our own lives and deaths.
Both rigorous and enchanting, The Vital Question provides a solution to life’s vital question: why are we as we are, and indeed, why are we here at all?
Early studies of the human brain used a simple method: wait for misfortune to strike -- strokes, seizures, infectious diseases, horrendous accidents -- and see how victims coped. In many cases their survival was miraculous, if puzzling. Observers were amazed by the transformations that took place when different parts of the brain were destroyed, altering victims' personalities. Parents suddenly couldn't recognize their own children. Pillars of the community became pathological liars. Some people couldn't speak but could still sing.
In The Tale of the Dueling Neurosurgeons, Sam Kean travels through time with stories of neurological curiosities: phantom limbs, Siamese twin brains, viruses that eat patients' memories, blind people who see through their tongues. He weaves these narratives together with prose that makes the pages fly by, to create a story of discovery that reaches back to the 1500s and the high-profile jousting accident that inspired this book's title.* With the lucid, masterful explanations and razor-sharp wit his fans have come to expect, Kean explores the brain's secret passageways and recounts the forgotten tales of the ordinary people whose struggles, resilience, and deep humanity made neuroscience possible.
*"The Tale of the Dueling Neurosurgeons" refers to the case of French king Henri II, who in 1559 was lanced through the skull during a joust, resulting in one of the most significant cases in neuroscience history. For hundreds of years scientists have gained important lessons from traumatic accidents and illnesses, and such misfortunes still represent their greatest resource for discovery.
* Hundreds of questions and many review tests
* Key concepts and terms defined and explained
Master key concepts. Answer challenging questions. Prepare forexams. Learn at your own pace.
Are viruses living? How does photosynthesis occur? Is cloning aform of sexual or asexual reproduction? What is Anton vanLeeuwenhoek known for? With Biology: A Self-Teaching Guide, SecondEdition, you'll discover the answers to these questions and manymore.
Steven Garber explains all the major biological concepts and termsin this newly revised edition, including the origin of life,evolution, cell biology, reproduction, physiology, and botany. Thestep-by-step, clearly structured format of Biology makes it fullyaccessible to all levels of students, providing an easilyunderstood, comprehensive treatment of all aspects of lifescience.
Like all Self-Teaching Guides, Biology allows you to buildgradually on what you have learned-at your own pace. Questions andself-tests reinforce the information in each chapter and allow youto skip ahead or focus on specific areas of concern. Packed withuseful, up-to-date information, this clear, concise volume is avaluable learning tool and reference source for anyone who needs tomaster the science of life.
By showing us the true nature of chance and revealing the psychological illusions that cause us to misjudge the world around us, Mlodinow gives us the tools we need to make more informed decisions. From the classroom to the courtroom and from financial markets to supermarkets, Mlodinow's intriguing and illuminating look at how randomness, chance, and probability affect our daily lives will intrigue, awe, and inspire.
From the Trade Paperback edition.
In First Contact, Marc Kaufman provides a gripping tour of the magnificent new science of astrobiology that is closing in on the discovery of extraterrestrial life. In recent decades, scientists generally held that the genesis of life was unique to Earth: It was too delicate a process, and the conditions needed to support it too fragile, for it to exist anywhere else. But we are now on the verge of the biggest discovery since Copernicus and Galileo told us that Earth is not at the center of the universe. New scientific breakthroughs have revolutionized our assumptions about the building blocks of life and where it may be found. Scientists have hunted down and identified exoplanets, those mysterious balls in the universe that orbit distant suns not too different from our own. They have discovered extremophiles, the extraordinary microbes that thrive in environments of intense heat or cold that may mimic the inhospitable conditions of other planets. They have landed rovers on Mars and detected its methane, a possible signature of past life. And they have created sophisticated equipment to sweep the sky for distant radio signals and to explore the deep icebound lakes of Antarctica. Each of these developments has brought forth a new generation of out-of-the-box researchers, adventurers, and thinkers who are each part Carl Sagan, part Indiana Jones, part Watson and Crick—and part forensic specialists on CSI: Mars.
In this masterful book, Kaufman takes us to the frontiers of astrobiology’s quest for extraterrestrial life and shows how this quest is inextricably linked with the quest to understand life on Earth. He takes us deep under the glaciers of Antarctica, into the mouth of an Alaskan volcano, and beneath the Earth into the unbearable heat of a South African mine, and leads us to the world’s driest desert. For thousands of years, humans have wondered about who and what might be living beyond the confines of our planet. First Contact transports us into the cosmos to bring those musings back to Earth and recast our humanity.
Need to get a handle on molecular and cell biology? Thiseasy-to-understand guide explains the structure and function of thecell and how recombinant DNA technology is changing the face ofscience and medicine. You discover how fundamental principles andconcepts relate to everyday life. Plus, you get plenty of studytips to improve your grades and score higher on exams!Explore the world of the cell — take a tour inside thestructure and function of cells and see how viruses attack anddestroy them
Understand the stuff of life (molecules) — get up to speedon the structure of atoms, types of bonds, carbohydrates, proteins,DNA, RNA, and lipids
Watch as cells function and reproduce — see how cellscommunicate, obtain matter and energy, and copy themselves forgrowth, repair, and reproduction
Make sense of genetics — learn how parental cells organizetheir DNA during sexual reproduction and how scientists can predictinheritance patterns
Decode a cell's underlying programming — examine how DNA isread by cells, how it determines the traits of organisms, and howit's regulated by the cell
Harness the power of DNA — discover how scientists usemolecular biology to explore genomes and solve current worldproblems
Open the book and find:Easy-to-follow explanations of key topics
The life of a cell — what it needs to survive andreproduce
Why molecules are so vital to cells
Rules that govern cell behavior
Laws of thermodynamics and cellular work
The principles of Mendelian genetics
Useful Web sites
Important events in the development of DNA technology
Ten great ways to improve your biology grade
Few other books have created such a lasting storm of controversy as The Origin of Species. Darwin’s theory that species derive from other species by a gradual evolutionary process and that the average level of each species is heightened by the “survival of the fittest” stirred up popular debate to fever pitch. Its acceptance revolutionized the course of science.
As Sir Julian Huxley, the noted biologist, points out in his illuminating introduction, the importance of Darwin’s contribution to modern scientific knowledge is almost impossible to evaluate: “a truly great book, one which can still be read with profit by professional biologist.”
Includes an Introduction by Sir Julian Huxley
Birds are astonishingly intelligent creatures. According to revolutionary new research, some birds rival primates and even humans in their remarkable forms of intelligence. In The Genius of Birds, acclaimed author Jennifer Ackerman explores their newly discovered brilliance and how it came about.
As she travels around the world to the most cutting-edge frontiers of research, Ackerman not only tells the story of the recently uncovered genius of birds but also delves deeply into the latest findings about the bird brain itself that are shifting our view of what it means to be intelligent. At once personal yet scientific, richly informative and beautifully written, The Genius of Birds celebrates the triumphs of these surprising and fiercely intelligent creatures.
Legends don't come close to capturing the incredible story of the coyote In the face of centuries of campaigns of annihilation employing gases, helicopters, and engineered epidemics, coyotes didn't just survive, they thrived, expanding across the continent from Alaska to New York. In the war between humans and coyotes, coyotes have won, hands-down. Coyote America is the illuminating five-million-year biography of this extraordinary animal, from its origins to its apotheosis. It is one of the great epics of our time.
Interweaving physics, astronomy, chemistry, geology, and biology, this sweeping account tells Earth’s complete story, from the synthesis of chemical elements in stars, to the formation of the Solar System, to the evolution of a habitable climate on Earth, to the origin of life and humankind. The book also addresses the search for other habitable worlds in the Milky Way and contemplates whether Earth will remain habitable as our influence on global climate grows. It concludes by considering the ways in which humankind can sustain Earth’s habitability and perhaps even participate in further planetary evolution.
Like no other book, How to Build a Habitable Planet provides an understanding of Earth in its broadest context, as well as a greater appreciation of its possibly rare ability to sustain life over geologic time.
Leading schools that have ordered, recommended for reading, or adopted this book for course use:
Arizona State University Brooklyn College CUNY Columbia University Cornell University ETH Zurich Georgia Institute of Technology Harvard University Johns Hopkins University Luther College Northwestern University Ohio State University Oxford Brookes University Pan American University Rutgers University State University of New York at Binghamton Texas A&M University Trinity College Dublin University of Bristol University of California-Los Angeles University of Cambridge University Of Chicago University of Colorado at Boulder University of Glasgow University of Leicester University of Maine, Farmington University of Michigan University of North Carolina at Chapel Hill University of North Georgia University of Nottingham University of Oregon University of Oxford University of Portsmouth University of Southampton University of Ulster University of Victoria University of Wyoming Western Kentucky University Yale University
In the past decade, we have learned more about how dogs think than in the last century. Breakthroughs in cognitive science, pioneered by Brian Hare, have proven dogs have a kind of genius for getting along with people that is unique in the animal kingdom. This dog genius revolution is transforming how we live and work with our canine friends, including how we train them. Does your dog feel guilt? Is she pretending she can't hear you? Does she want affection—or just your sandwich? In The Genius of Dogs, Brian Hare and Vanessa Woods lay out what discoveries at the Duke Canine Cognition Lab and other research facilities around the world are revealing about how your dog thinks and how we humans can have even deeper relationships with our best four-legged friends.
Dr. Kenneth Kamler has spent years observing exactly what happens. A vice president of the legendary Explorers Club, he has climbed, dived, sledded, floated, and trekked through some of the most treacherous and remote regions in the world. A consultant for NASA, Yale University, and the National Geographic Society, he has explored undersea caves, crossed the frozen Antarctic wastelands, and stitched a boy's hand back together while kneeling in knee-deep Amazonian mud. He was the only doctor on Everest during the tragic expedition documented in Jon Krakauer's Into Thin Air and helped treat its survivors. Kamler has devoted his life to investigating how our bodies respond to "environmental insults"-a nice way of saying the things that can kill us-and watched while some succumbed to them and others, sometimes miraculously, overcome them.
Words like "extreme" and "survival" have lost some of their value from overuse and media hype. By showing us what happens when life itself is at stake, and the body's capacities put to their greatest test, this book reminds us what they truly mean. Divided into six sections-jungle, open sea, desert, underwater, high altitude, and outer space-Surviving the Extremes uses first-hand testimony and documented accounts to illustrate what happens in environments where our instinctive survival strategies must become fully engaged. These stories reveal how infinitely complex are the workings of the human body-and also how heartbreakingly fragile. At the heart of this book is a quest for the source of our will to survive and the haunting question of why some can, and others cannot, summon its awesome and nearly mystical power at their moment of greatest need.
Surgeon, explorer, and masterful storyteller, Kamler takes us to the farthest reaches of the earth as well as into the uncharted territory within the human brain. Surviving the Extremes is a scientific nail-biter no reader will forget.
The Most Dangerous Animal asks what it is about human nature that makes it possible for human beings to regularly slaughter their own kind. It tells the story of why all human beings have the potential to be hideously cruel and destructive to one another. Why are we our own worst enemy? The book shows us that war has been with us---in one form or another---since prehistoric times, and looking at the behavior of our close relatives, the chimpanzees, it argues that a penchant for group violence has been bred into us over millions of years of biological evolution. The Most Dangerous Animal takes the reader on a journey through evolution, history, anthropology, and psychology, showing how and why the human mind has a dual nature: on the one hand, we are ferocious, dangerous animals who regularly commit terrible atrocities against our own kind, on the other, we have a deep aversion to killing, a horror of taking human life. Meticulously researched and far-reaching in scope and with examples taken from ancient and modern history, The Most Dangerous Animal delivers a sobering lesson for an increasingly dangerous world.
As wolf populations have rebounded, scientific studies of them have also flourished. But there hasn't been a systematic, comprehensive overview of wolf biology since 1970. In Wolves, many of the world's leading wolf experts provide state-of-the-art coverage of just about everything you could want to know about these fascinating creatures. Individual chapters cover wolf social ecology, behavior, communication, feeding habits and hunting techniques, population dynamics, physiology and pathology, molecular genetics, evolution and taxonomy, interactions with nonhuman animals such as bears and coyotes, reintroduction, interactions with humans, and conservation and recovery efforts. The book discusses both gray and red wolves in detail and includes information about wolves around the world, from the United States and Canada to Italy, Romania, Saudi Arabia, Israel, India, and Mongolia. Wolves is also extensively illustrated with black and white photos, line drawings, maps, and fifty color plates.
Unrivalled in scope and comprehensiveness, Wolves will become the definitive resource on these extraordinary animals for scientists and amateurs alike.
“An excellent compilation of current knowledge, with contributions from all the main players in wolf research. . . . It is designed for a wide readership, and certainly the language and style will appeal to both scientists and lucophiles alike. . . . This is an excellent summary of current knowledge and will remain the standard reference work for a long time to come.”—Stephen Harris, New Scientist
“This is the place to find almost any fact you want about wolves.”—Stephen Mills, BBC Wildlife Magazine
Why do people believe bunk? And what causes them to embrace such pseudoscientific beliefs and practices? Noted skeptic Massimo Pigliucci sets out to separate the fact from the fantasy in this entertaining exploration of the nature of science, the borderlands of fringe science, and—borrowing a famous phrase from philosopher Jeremy Bentham—the nonsense on stilts. Presenting case studies on a number of controversial topics, Pigliucci cuts through the ambiguity surrounding science to look more closely at how science is conducted, how it is disseminated, how it is interpreted, and what it means to our society. The result is in many ways a “taxonomy of bunk” that explores the intersection of science and culture at large.
No one—not the public intellectuals in the culture wars between defenders and detractors of science nor the believers of pseudoscience themselves—is spared Pigliucci’s incisive analysis. In the end, Nonsense on Stilts is a timely reminder of the need to maintain a line between expertise and assumption. Broad in scope and implication, it is also ultimately a captivating guide for the intelligent citizen who wishes to make up her own mind while navigating the perilous debates that will affect the future of our planet.
From the man who Oliver Sacks hailed as “one of the best scientist/writers of our time,” a collection of sharply observed, uproariously funny essays on the biology of human culture and behavior.
In the tradition of Stephen Jay Gould and Oliver Sacks, Robert Sapolsky offers a sparkling and erudite collection of essays about science, the world, and our relation to both. “The Trouble with Testosterone” explores the influence of that notorious hormone on male aggression. “Curious George’s Pharmacy” reexamines recent exciting claims that wild primates know how to medicate themselves with forest plants. “Junk Food Monkeys” relates the adventures of a troop of baboons who stumble upon a tourist garbage dump. And “Circling the Blanket for God” examines the neurobiological roots underlying religious belief.
Drawing on his career as an evolutionary biologist and neurobiologist, Robert Sapolsky writes about the natural world vividly and insightfully. With candor, humor, and rich observations, these essays marry cutting-edge science with humanity, illuminating the interconnectedness of the world’s inhabitants with skill and flair.
This is the story of how your life shapes your brain, and how your brain shapes your life.
(A companion to the six-part PBS series. Color illustrations throughout.)
For laughter? For the creation of art?
Why do dogs have curly tails?
What can microbes tell us about morality?
These and many other questions are tackled by renowned evolutionist David Sloan Wilson in this witty and groundbreaking new book. With stories that entertain as much as they inform, Wilson outlines the basic principles of evolution and shows how, properly understood, they can illuminate the length and breadth of creation, from the origin of life to the nature of religion. Now everyone can move beyond the sterile debates about creationism and intelligent design to share Darwin’s panoramic view of animal and human life, seamlessly connected to each other.
Evolution, as Wilson explains, is not just about dinosaurs and human origins, but about why all species behave as they do—from beetles that devour their own young, to bees that function as a collective brain, to dogs that are smarter in some respects than our closest ape relatives. And basic evolutionary principles are also the foundation for humanity’s capacity for symbolic thought, culture, and morality.
In example after example, Wilson sheds new light on Darwin’s grand theory and how it can be applied to daily life. By turns thoughtful, provocative, and daringly funny, Evolution for Everyone addresses some of the deepest philosophical and social issues of this or any age. In helping us come to a deeper understanding of human beings and our place in the world, it might also help us to improve that world.
From the Hardcover edition.
Possessing no supernatural powers, Batman is the most realistic of all the superheroes. His feats are achieved through rigorous training and mental discipline, and with the aid of fantastic gadgets. Drawing on his training as a neuroscientist, kinesiologist, and martial artist, E. Paul Zehr explores the question: Could a mortal ever become Batman?
Zehr discusses the physical training necessary to maintain bad-guy-fighting readiness while relating the science underlying this process, from strength conditioning to the cognitive changes a person would endure in undertaking such a regimen. In probing what a real-life Batman could achieve, Zehr considers the level of punishment a consummately fit and trained person could handle, how hard and fast such a person could punch and kick, and the number of adversaries that individual could dispatch. He also tells us what it would be like to fight while wearing a batsuit and the amount of food we'd need to consume each day to maintain vigilance as Gotham City's guardian.
A fun foray of escapism grounded in sound science, Becoming Batman provides the background for attaining the realizable—though extreme—level of human performance that would allow you to be a superhero.
The common ancestry of all humanity
The role of genes in sickness and health
Debates over the use of genetic technology
Written in an engaging, narrative manner, this concise introduction is an ideal starting point for anyone who wants to know more about genes, DNA, and the genetic ties that bind us all.
The most disruptive force on the planet resides in DNA. Biotech companies and academic researchers are just beginning to unlock the potential of piecing together life from scratch. Champions of synthetic biology believe that turning genetic code into Lego-like blocks to build never-before-seen organisms could solve the thorniest challenges in medicine, energy, and environmental protection. But as the hackers who cracked open the potential of the personal computer and the Internet proved, the most revolutionary discoveries often emerge from out-of-the-way places, forged by brilliant outsiders with few resources besides boundless energy and great ideas.
In Biopunk, Marcus Wohlsen chronicles a growing community of DIY scientists working outside the walls of corporations and universities who are committed to democratizing DNA the way the Internet did information. The "biohacking" movement, now in its early, heady days, aims to unleash an outbreak of genetically modified innovation by making the tools and techniques of biotechnology accessible to everyone. Borrowing their idealism from the worlds of open-source software, artisinal food, Internet startups, and the Peace Corps, biopunks are devoted advocates for open-sourcing the basic code of life. They believe in the power of individuals with access to DNA to solve the world's biggest problems.
You'll meet a new breed of hackers who aren't afraid to get their hands wet, from entrepreneurs who aim to bring DNA-based medical tools to the poorest of the poor to a curious tinkerer who believes a tub of yogurt and a jellyfish gene could protect the world's food supply. These biohackers include:
-A duo who started a cancer drug company in their kitchen
-A team who built an open-source DNA copy machine
-A woman who developed a genetic test in her apartment for a deadly disease that had stricken her family
Along with the potential of citizen science to bring about disruptive change, Wohlsen explores the risks of DIY bioterrorism, the possibility of genetic engineering experiments gone awry, and whether the ability to design life from scratch on a laptop might come sooner than we think.
This eBook edition has been formatted for on-screen viewing with cross-linked questions, answers, and explanations.
Practice makes perfect—and The Princeton Review’s 550 AP Biology Practice Questions gives you everything you need to work your way to the top. Inside, you’ll find tips and strategies for tackling and overcoming challenging questions, plus all the practice you need to get the score you want.
Practice Your Way to Perfection.
• 2 full-length practice tests and 16 practice drills covering each subject type
• Practice drills organized by the 4 "Big Ideas"
Academic and Strategic Explanations.
• Detailed walk-throughs of free-response questions to help you write a winning essay
• Answer keys and detailed explanations for each drill and test question
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The Essentials For Dummies Series
Dummies is proud to present our new series, The Essentials ForDummies. Now students who are prepping for exams, preparing tostudy new material, or who just need a refresher can have aconcise, easy-to-understand review guide that covers an entirecourse by concentrating solely on the most important concepts. Fromalgebra and chemistry to grammar and Spanish, our expert authorsfocus on the skills students most need to succeed in a subject.
"I tried to have well-trained police officers and deputies. Bill is paying attention to the training of beekeepers." Johannes F. Spreen, retired police commissioner of Detroit and sheriff of Oakland County, Michigan.
"Honey's anti-bacterial qualities may make it valuable in treating microbes that have become resistant to antibiotics such as methicillin-resistant Staphylococcus aureus-MRSA." Dr. Diane Holloway, formerly in practice at Presbyterian Hospital, Dallas, Texas.
"This knowledge should help you in minimizing any significant impact that the Africanized bee could have on your daily life." Fire Chief Robert Biscoe, Fire District of Sun City West, Arizona.
This well-illustrated text is perfect for beginning beekeepers, experienced beekeepers and their employees, entomology students, and the layman. It offers instructions and information for:
Problems with helpers, animals, people, health, and disasters Working with beeswax, pollen, enzymes, and package bees Dealing with diseases, mites, colony collapse, and Africanized bees Robbing, extracting, bee removal, re-queening and queen rearing
Fifty years ago, a young astronomer named Frank Drake first pointed a radio telescope at nearby stars in the hope of picking up a signal from an alien civilization. Thus began one of the boldest scientific projects in history, the Search for Extraterrestrial Intelligence (SETI). After a half-century of scanning the skies, however, astronomers have little to report but an eerie silence—eerie because many scientists are convinced that the universe is teeming with life. Physicist and astrobiologist Paul Davies has been closely involved with SETI for three decades and chairs the SETI Post-Detection Taskgroup, charged with deciding what to do if we’re suddenly confronted with evidence of alien intelligence. He believes the search so far has fallen into an anthropocentric trap—assuming that an alien species will look, think, and behave much like us. In this provocative book Davies refocuses the search, challenging existing ideas of what form an alien intelligence might take, how it might try to communicate with us, and how we should respond if it does.
5 Steps to a 5: AP Biology features an effective, 5-step plan to guide your preparation program and help you build the skills, knowledge, and test-taking confidence you need to succeed. This fully revised edition covers the latest course syllabus and matches the latest exam. It also includes access to McGraw-Hill Education’s AP Planner app, which will enable you to create your own customized study schedule on your mobile device.AP Planner app features daily practice assignment notifications delivered to your mobile device 2 complete practice AP Biology exams Access to online AP Biology quizzes 3 separate study plans to fit your learning style
Perhaps the most readable and accessible of the great works of scientific inquiry, The Origin of Species sold out its first printing on the very day it was published in 1859. Theologians quickly labeled Charles Darwin the most dangerous man in England and, as the Saturday Review noted, the uproar over the book quickly “passed beyond the bounds of the study and lecture-room into the drawing-room and the public street.” Based largely on Darwin’s experience as a naturalist while on a five-year voyage aboard H. M. S. Beagle, The Origin of Species set forth a theory of evolution and natural selection that challenged contemporary beliefs about divine providence and the immutability of species. This Modern Library edition includes a Foreword by the Pulitzer Prize–winning science historian Edward J. Larson, an introductory historical sketch, and a glossary Darwin later added to the original text.
• what wildlife law is, what it covers, and what it seeks to achieve;
• constitutional issues and key federal statutes;
• wildlife liability issues, from spider bites to escaped zoo animals;
• state game laws, hunting and fishing rights of Indian tribes;
• and the Endangered Species Act.Wildlife Law fills a long-standing gap in the literature and introduces readers to the basics of wildlife law while exploring such current controversies as endangered species protection, tribal fishing rights, game ranches, and the challenges of constructing wildlife corridors. It is a much-needed addition to the bookshelf of everyone working with or concerned about wildlife in the United States.
This major new edition features many topics not covered in the original, including graphical models, random forests, ensemble methods, least angle regression & path algorithms for the lasso, non-negative matrix factorization, and spectral clustering. There is also a chapter on methods for ``wide'' data (p bigger than n), including multiple testing and false discovery rates.
Trevor Hastie, Robert Tibshirani, and Jerome Friedman are professors of statistics at Stanford University. They are prominent researchers in this area: Hastie and Tibshirani developed generalized additive models and wrote a popular book of that title. Hastie co-developed much of the statistical modeling software and environment in R/S-PLUS and invented principal curves and surfaces. Tibshirani proposed the lasso and is co-author of the very successful An Introduction to the Bootstrap. Friedman is the co-inventor of many data-mining tools including CART, MARS, projection pursuit and gradient boosting.
In this second edition, the author includes greatly expanded treatments of families of lycophytes, ferns, gymnosperms, and flowering plants (all with full-color plates), a new chapter on species concepts and the role of systematics in conservation biology, and a new appendix summarizing basic statistical and morphometric techniques used in plant systematics studies. An explanation of maximum likelihood and Bayesian inference algorithms is included in methods of phylogenetic inference, and chapters on morphology and plant nomenclature have been augmented with new material.
The second edition of Plant Systematics has been expanded to include:
* Fifteen fern families, 9 gymnosperm families, and an increase of angiosperm family treatments from 100 to 129. Each family description includes a plate of full color photographs, illustrating exemplars of the group along with dissected and labeled material to show diagnostic features.
* A new chapter on species concepts and the role and impact of plant systematics in conservation biology.
* A new appendix on statistical and morphometric techniques in plant systematics.
* In addition, the second edition contains more detailed explanations of maximum likelihood and Bayesian phylogeny inference methods, an expanded coverage and glossary of morphological terms, and an updated chapter on botanical nomenclature.
The book starts at an elementary level of mathematical modeling, assuming that the reader has had high school mathematics and first-year calculus. Otto and Day then gradually build in depth and complexity, from classic models in ecology and evolution to more intricate class-structured and probabilistic models. The authors provide primers with instructive exercises to introduce readers to the more advanced subjects of linear algebra and probability theory. Through examples, they describe how models have been used to understand such topics as the spread of HIV, chaos, the age structure of a country, speciation, and extinction.
Ecologists and evolutionary biologists today need enough mathematical training to be able to assess the power and limits of biological models and to develop theories and models themselves. This innovative book will be an indispensable guide to the world of mathematical models for the next generation of biologists.
A how-to guide for developing new mathematical models in biology
Provides step-by-step recipes for constructing and analyzing models
Interesting biological applications
Explores classical models in ecology and evolution
Questions at the end of every chapter
Primers cover important mathematical topics
Exercises with answers
Appendixes summarize useful rules
Labs and advanced material available
In 1760, the 28-year-old Mutis—newly appointed as the personal physician of the Viceroy of the New Kingdom of Granada—embarked on a 48-year exploration of the natural world of northern South America. His thirst for knowledge led Mutis to study the region's flora, become a professor of mathematics, construct the first astronomical observatory in the Western Hemisphere, and amass one of the largest scientific libraries in the world. He translated Newton's writings and penned essays about Copernicus; lectured extensively on astronomy, geography, and meteorology; and eventually became a priest. But, as two-time Pulitzer Prize–winner Edward O. Wilson and Spanish natural history scholar José M. Gómez Durán reveal in this enjoyable and illustrative account, one of Mutis's most magnificent accomplishments involved ants.
Acting at the urging of Carl Linnaeus—the father of taxonomy—shortly after he arrived in the New Kingdom of Granada, Mutis began studying the ants that swarmed everywhere. Though he lacked any entomological training, Mutis built his own classification for the species he found and named at a time when New World entomology was largely nonexistent. His unorthodox catalog of army ants, leafcutters, and other six-legged creatures found along the banks of the Magdalena provided a starting point for future study.
Wilson and Durán weave a compelling, fast-paced story of ants on the march and the eighteenth-century scientist who followed them. A unique glance into the early world of science exploration, Kingdom of Ants is a delight to read and filled with intriguing information.
Until recently, we had thought our microbes hardly mattered, but science is revealing a different story, one in which microbes run our bodies and becoming a healthy human is impossible without them.
In this riveting, shocking, and beautifully written book, biologist Alanna Collen draws on the latest scientific research to show how our personal colony of microbes influences our weight, our immune system, our mental health, and even our choice of partner. She argues that so many of our modern diseases—obesity, autism, mental illness, digestive disorders, allergies, autoimmunity afflictions, and even cancer—have their root in our failure to cherish our most fundamental and enduring relationship: that with our personal colony of microbes.
Many of the questions about modern diseases left unanswered by the Human Genome Project are illuminated by this new science. And the good news is that unlike our human cells, we can change our microbes for the better. Collen's book is a revelatory and indispensable guide. It is science writing at its most relevant: life—and your body—will never seem the same again.
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