The latest edition of a highly successful textbook, Mass Spectrometry, Third Edition provides students with a complete overview of the principles, theories and key applications of modern mass spectrometry. All instrumental aspects of mass spectrometry are clearly and concisely described: sources, analysers and detectors. Tandem mass spectrometry is introduced early on and then developed in more detail in a later chapter. Emphasis is placed throughout the text on optimal utilisation conditions. Various fragmentation patterns are described together with analytical information that derives from the mass spectra.

This new edition has been thoroughly revised and updated and has been redesigned to give the book a more contemporary look. As with previous editions it contains numerous examples, references and a series of exercises of increasing difficulty to encourage student understanding. Updates include: Increased coverage of MALDI and ESI, more detailed description of time of flight spectrometers, new material on isotope ratio mass spectrometry, and an expanded range of applications.

Mass Spectrometry, Third Edition is an invaluable resource for all undergraduate and postgraduate students using this technique in departments of chemistry, biochemistry, medicine, pharmacology, agriculture, material science and food science. It is also of interest for researchers looking for an overview of the latest techniques and developments.

This text is aimed at people who have some familiarity with high-resolution NMR and who wish to deepen their understanding of how NMR experiments actually ‘work’. This revised and updated edition takes the same approach as the highly-acclaimed first edition. The text concentrates on the description of commonly-used experiments and explains in detail the theory behind how such experiments work. The quantum mechanical tools needed to analyse pulse sequences are introduced set by step, but the approach is relatively informal with the emphasis on obtaining a good understanding of how the experiments actually work. The use of two-colour printing and a new larger format improves the readability of the text. In addition, a number of new topics have been introduced: How product operators can be extended to describe experiments in AX2 and AX3 spin systems, thus making it possible to discuss the important APT, INEPT and DEPT experiments often used in carbon-13 NMR. Spin system analysis i.e. how shifts and couplings can be extracted from strongly-coupled (second-order) spectra. How the presence of chemically equivalent spins leads to spectral features which are somewhat unusual and possibly misleading, even at high magnetic fields. A discussion of chemical exchange effects has been introduced in order to help with the explanation of transverse relaxation. The double-quantum spectroscopy of a three-spin system is now considered in more detail.

Reviews of the First Edition

“For anyone wishing to know what really goes on in their NMR experiments, I would highly recommend this book” – Chemistry World

“…I warmly recommend for budding NMR spectroscopists, or others who wish to deepen their understanding of elementary NMR theory or theoretical tools” – Magnetic Resonance in Chemistry

“Telescopes and Techniques” has proved itself in its first edition, having become probably one of the most widely used astronomy texts, both for numerate amateur astronomers and for astronomy and astrophysics undergraduates. The first and second editions of the book were widely used as set texts for introductory practical astronomy courses in many universities.

This book guides the reader through the mathematics, physics and practical techniques needed to use telescopes (from small amateur models to the larger instruments installed in many colleges) and to observe objects in the sky. Mathematics to around Advanced Placement standard (US) or A level (UK) is assumed, although High School Diploma (US) or GCSE-level (UK) mathematics plus some basic trigonometry will suffice most of the time. Most of the physics and engineering involved is described fully and requires no prior knowledge or experience.

This is a ‘how to’ book that provides the knowledge and background required to understand how and why telescopes work. Equipped with the techniques discussed in this book, the observer will be able to operate with confidence his or her telescope and to optimize its performance for a particular purpose. In principle the observer could calculate his or her own predictions of planetary positions (ephemerides), but more realistically the observer will be able to understand the published data lists properly instead of just treating them as ‘recipes.’ When the observer has obtained measurements, he/she will be able to analyze them in a scientific manner and to understand the significance and meaning of the results.

“Telescopes and Techniques, 3rd Edition” fills a niche at the start of an undergraduate astronomer’s university studies, as shown by it having been widely adopted as a set textbook. This third edition is now needed to update its material with the many new observing developments and study areas that have come into prominence since it was published. The book concentrates on the knowledge needed to understand how small(ish) optical telescopes function, their main designs and how to set them up, plus introducing the reader to the many ways in which objects in the sky change their positions and how they may be observed. Both visual and electronic imaging techniques are covered, together with an introduction to how data (measurements) should be processed and analyzed. A simple introduction to radio telescopes is also included. Brief coverage of the most advanced topics of photometry and spectroscopy are included, but mainly to enable the reader to see some of the developments possible from the basic observing techniques covered in the main parts of the book.

The derivation of structural information from spectroscopic data is now an integral part of organic chemistry courses at all Universities.  A critical part of any such course is a suitable set of problems to develop the student’s understanding of how structures are determined from spectra. 

Organic Structures from Spectra, Fifth Edition is a carefully chosen set of more than 280 structural problems employing the major modern spectroscopic techniques, a selection of 27 problems using 2D-NMR spectroscopy, more than 20 problems specifically dealing with the interpretation of spin-spin coupling in proton NMR spectra and 8 problems based on the quantitative analysis of mixtures using proton and carbon NMR spectroscopy.  All of the problems are graded to develop and consolidate the student’s understanding of organic spectroscopy.  The accompanying text is descriptive and only explains the underlying theory at a level which is sufficient to tackle the problems.  The text includes condensed tables of characteristic spectral properties covering the frequently encountered functional groups.

The examples themselves have been selected to include all important common structural features found in organic compounds and to emphasise connectivity arguments.  Many of the compounds were synthesised specifically for this purpose.  There are many more easy problems, to build confidence and demonstrate basic principles, than in other collections. 

The fifth edition of this popular textbook:

• includes more than 250 new spectra and more than 25 completely new problems;
• now incorporates an expanded suite of new problems dealing with the analysis of 2D NMR spectra (COSY, C H Correlation spectroscopy, HMBC, NOESY and TOCSY); 
• has been expanded and updated to reflect the new developments in NMR and to retire older techniques that are no longer in common use;
• provides a set of problems dealing specifically with the quantitative analysis of mixtures using NMR spectroscopy;
• features proton NMR spectra obtained at 200, 400 and 600 MHz and 13C NMR spectra include DEPT experiments as well as proton-coupled experiments;
• contains 6 problems in the style of the experimental section of a research paper and two examples of fully worked solutions.

Organic Structures from Spectra, Fifth Edition will prove invaluable for students of Chemistry, Pharmacy and Biochemistry taking a first course in Organic Chemistry.

Contents
Preface 
Introduction 
Ultraviolet Spectroscopy 
Infrared Spectroscopy
Mass Spectrometry 
Nuclear Magnetic Resonance Spectroscopy 
2DNMR
Problems 
Index

Reviews from earlier editions

“Your book is becoming one of the “go to” books for teaching structure determination here in the States.  Great work!”

“…I would definitely state that this book is the most useful aid to basic organic spectroscopy teaching in existence and I would strongly recommend every instructor in this area to use it either as a source of examples or as a class textbook”.
Magnetic Resonance in Chemistry

“Over the past year I have trained many students using problems in your book - they initially find it as a task.  But after doing 3-4 problems with all their brains activities... working out the rest of the problems become a mania.  They get addicted to the problem solving and every time they solve a problem by themselves, their confident level also increases.”

 “I am teaching the fundamentals of Molecular Spectroscopy and your books represent excellent sources of spectroscopic problems for students.”

This book reflects the dramatic increase in the number of Raman spectrometers being sold to and used by non-expert practitioners. It contains coverage of Resonance Raman and SERS, two hot areas of Raman, in a form suitable for the non-expert. Builds Raman theory up in stages without overloading the reader with complex theory Includes two chapters on instrumentation and interpretation that shows how Raman spectra can be obtained and interpreted Explains the potential of using Raman spectroscopy in a wide variety of applications Includes detailed, but concise information and worked examples

Spectroscopy is used in physical and analytical chemistry for the identification of substances through the spectrum emitted from or absorbed by them. The derivation of structural information from spectroscopic data is now an integral part of many courses in chemistry and related subjects at most universities.

This workbook:

Features exercises to help develop the student's understanding of how structures are determined from spectra and to promote the student's own interpretation of different spectra. Covers a large range of spectroscopic data, including mass spectrometry, infrared and 1H and 13C nuclear magnetic resonance, typically used in the routine analysis of small-sized organic molecules. Presents in full-color, in a workbook-friendly format the spectra for interpretation with explanations and analyses on the facing page.
Related to the workbook the authors have an online resource of the problems featured in the workbook, available at: htttp://spectros.unice.fr/ By using the print edition alongside the online spectra, students will be able to enhance their understanding of the interpretation of multiple spectra.

The text Organic Structures from 2D NMR Spectra contains a graded set of structural problems employing 2D-NMR spectroscopy. The Instructors Guide and Solutions Manual to Organic Structures from 2D NMR Spectra is a set of step-by-step worked solutions to every problem in Organic Structures from 2D NMR Spectra. While it is absolutely clear that there are many ways to get to the correct solution of any of the problems, the instructors guide contains at least one complete pathway to every one of the questions. In addition, the instructors guide carefully rationalises every peak in every spectrum in relation to the correct structure. The Instructors Guide and Solutions Manual to Organic Structures from 2D NMR Spectra: Is a complete set of worked solutions to the problems contained in Organic Structures from 2D NMR Spectra. Provides a step-by-step description of the process to derive structures from spectra as well as annotated 2D spectra indicating the origin of every cross peak. Highlights common artefacts and re-enforces the important characteristics of the most common techniques 2D NMR techniques including COSY, NOESY, HMBC, TOCSY, CH-Correlation and multiplicity-edited C-H Correlation. This guide is an essential aid to those teachers, lecturers and instructors who use Organic Structures from 2D NMR as a text to teach students of Chemistry, Pharmacy, Biochemistry and those taking courses in Organic Chemistry.

A richly illustrated undergraduate textbook on the physics and biology of light

Students in the physical and life sciences, and in engineering, need to know about the physics and biology of light. Recently, it has become increasingly clear that an understanding of the quantum nature of light is essential, both for the latest imaging technologies and to advance our knowledge of fundamental life processes, such as photosynthesis and human vision. From Photon to Neuron provides undergraduates with an accessible introduction to the physics of light and offers a unified view of a broad range of optical and biological phenomena. Along the way, this richly illustrated textbook builds the necessary background in neuroscience, photochemistry, and other disciplines, with applications to optogenetics, superresolution microscopy, the single-photon response of individual photoreceptor cells, and more.

With its integrated approach, From Photon to Neuron can be used as the basis for interdisciplinary courses in physics, biophysics, sensory neuroscience, biophotonics, bioengineering, or nanotechnology. The goal is always for students to gain the fluency needed to derive every result for themselves, so the book includes a wealth of exercises, including many that guide students to create computer-based solutions. Supplementary online materials include real experimental data to use with the exercises.

Assumes familiarity with first-year undergraduate physics and the corresponding math Overlaps the goals of the MCAT, which now includes data-based and statistical reasoning Advanced chapters and sections also make the book suitable for graduate courses An Instructor's Guide and illustration package is available to professors

With contributions by numerous experts

Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist.

* The first reference work on named reactions to present colored schemes for easier understanding
* 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples
* An opening list of abbreviations includes both structures and chemical names
* Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works
* Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools
* Extensive index quickly locates information using words found in text and drawings

Interpretive spectroscopy provides a basis for the establishment of cause-and-effect relationships between NIR spectrometer response and the chemical properties of the samples. Without established cause-effect relationships, the measured data has no true predictive significance. This interpretive process is key for achieving an analytical understanding of the measurement.

In the expanded second edition of Practical Guide and Spectral Atlas for Interpretive Near-Infrared Spectroscopy, the authors include new research, editorials, supplements, and molecular structural formulas, along with updated references and information on NIR spectra. The thoroughly updated and revised second edition offers a full library of color spectra in a larger format to ensure clarity and reader comprehension.

Providing a rich set of reference information required to interpret NIR spectra for research and industrial applications, this book:

Offers more than 300 figures representing all the major functional groups and their NIR frequency ranges Contains over 120 pages of tables and charts illustrating overlapping spectra Covers NIR spectra for organic compounds, including alkanes, carboxylic acids, amines, dienes, alkynes, heterocyclic compounds, amino acids, and aldehydes Provides comprehensive appendices with spectra-structure correlations, example spectra, and other useful data for interpreting NIR spectra

The aim of this book is to outline the physics of image formation, electron specimen interactions, imaging modes, the interpretation of micrographs and the use of quantitative modes "in scanning electron microscopy (SEM). lt forms a counterpart to Transmission Electron Microscopy (Vol. 36 of this Springer Series in Optical Sciences) . The book evolved from lectures delivered at the University of Münster and from a German text entitled Raster-Elektronenmikroskopie (Springer-Verlag), published in collaboration with my colleague Gerhard Pfefferkorn. In the introductory chapter, the principles of the SEM and of electron specimen interactions are described, the most important imaging modes and their associated contrast are summarized, and general aspects of eiemental analysis by x-ray and Auger electron emission are discussed. The electron gun and electron optics are discussed in Chap. 2 in order to show how an electron probe of small diameter can be formed, how the elec tron beam can be blanked at high frequencies for time-resolving exper iments and what problems have tobe taken into account when focusing.

Spin Dynamics: Basics of Nuclear Magnetic Resonance, Second Edition is a comprehensive and modern introduction which focuses on those essential principles and concepts needed for a thorough understanding of the subject, rather than the practical aspects. The quantum theory of nuclear magnets is presented within a strong physical framework, supported by figures. 

The book assumes only a basic knowledge of complex numbers and matrices, and provides the reader with numerous worked examples and exercises to encourage understanding. With the explicit aim of carefully developing the subject from the beginning, the text starts with coverage of quarks and nucleons and progresses through to a detailed explanation of several important NMR experiments, including NMR imaging, COSY, NOESY and TROSY. 

Completely revised and updated, the Second Edition features new material on the properties and distributions of isotopes, chemical shift anisotropy and quadrupolar interactions, Pake patterns, spin echoes, slice selection in NMR imaging, and a complete new chapter on the NMR spectroscopy of quadrupolar nuclei. New appendices have been included on Euler angles, and coherence selection by field gradients. As in the first edition, all material is heavily supported by graphics, much of which is new to this edition. 

Written for undergraduates and postgraduate students taking a first course in NMR spectroscopy and for those needing an up-to-date account of the subject, this multi-disciplinary book will appeal to chemical, physical, material, life, medical, earth and environmental scientists. The detailed physical insights will also make the book of interest for experienced spectroscopists and NMR researchers. 

• An accessible and carefully written introduction, designed to help students to fully understand this complex and dynamic subject

• Takes a multi-disciplinary approach, focusing on basic principles and concepts rather than the more practical aspects

• Presents a strong pedagogical approach throughout, with emphasis placed on individual spins to aid understanding

• Includes numerous worked examples, problems, further reading and additional notes

Praise from the reviews of the First Edition:

"This is an excellent book... that many teachers of NMR spectroscopy will cherish... It deserves to be a ‘classic’ among NMR spectroscopy texts." NMR IN BIOMEDICINE

"I strongly recommend this book to everyone…it is probably the best modern comprehensive description of the subject." ANGEWANDTE CHEMIE, INTERNATIONAL EDITION

This book presents a complete overview of the powerful but often misused technique of Electrochemical Impedance Spectroscopy (EIS). The book presents a systematic and complete overview of EIS. The book carefully describes EIS and its application in studies of electrocatalytic reactions and other electrochemical processes of practical interest. This book is directed towards graduate students and researchers in Electrochemistry. Concepts are illustrated through detailed graphics and numerous examples. The book also includes practice problems. Additional materials and solutions are available online.

Written in a concise and student-friendly way, this textbook focuses on the underlying principles of organic chemistry and provides the tools for understanding the nature of organic reactions. The author utilizes an integrated approach for organic chemistry, uniting in a logical manner the main reaction types and their mechanisms, compound classes and their typical reactions, organic spectroscopy and principles of structure elucidation.

The concept of this book - an integrated and comprehensive cov erage of all aspects of Raman spectroscopy by a group of specialist- took form nearly three years ago. It made a giant stride toward realiza tion when Dr. L. Woodward, whose outstanding work in this field had long been known to me, agreed to write an introductory chapter and made valuable suggestions concerning others who might be invited to contribute articles. However, many obstacles had to be overcome before this book finally became a reality. It is extremely difficult to prepare a multi author review of the state of knowledge in a rapidly growing field in such a way that all aspects are brought up to the same date. In our case, some workers who had originally agreed to contribute articles were forced to withdraw under the pressure of new commitments, and replacements had to be found. Others were unable to complete their contributions by the deadline date, so that the publication of the book had to be rescheduled. All this tended to work to the detriment of those authors who prepared their chapters as originally scheduled. An effort was made to give the authors most affected by this an opportunity to revise their papers, but of course an arbitrary cutoff date had to be set to avoid an endless spiral of revision and updating.

Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful and widely used techniques in chemical research for investigating structures and dynamics of molecules. Advanced methods can even be utilized for structure determinations of biopolymers, for example proteins or nucleic acids. NMR is also used in medicine for magnetic resonance imaging (MRI). The method is based on spectral lines of different atomic nuclei that are excited when a strong magnetic field and a radiofrequency transmitter are applied. The method is very sensitive to the features of molecular structure because also the neighboring atoms influence the signals from individual nuclei and this is
important for determining the 3D-structure of molecules.

This new edition of the popular classic has a clear style and a highly practical, mostly non-mathematical approach. Many examples are taken from organic and organometallic chemistry, making this book an invaluable guide to undergraduate and graduate students of organic chemistry, biochemistry, spectroscopy or physical chemistry, and to researchers using this well-established and extremely important technique. Problems and solutions are included.

This book highlights the basics of crystal optics methods and refractive index (RI) measurement techniques in various solids, as well as their scientific and technological applications. In addition to new techniques for cases when traditional techniques are impractical, such as for highly refracting powders, anomalous dispersion of light in the studied solid, or for colloids, it also describes conventional methods of RI measurement.

The concept of adiabatic electronic potential-energy surfaces, defined by the Born-Oppenheimer approximation, is fundamental to our thinking about chemical processes. Recent computational as well as experimental studies have produced ample evidence that the so-called conical intersections of electronic energy surfaces, predicted by von Neumann and Wigner in 1929, are the rule rather than the exception in polyatomic molecules. It is nowadays increasingly recognized that conical intersections play a key mechanistic role in chemical reaction dynamics. This volume provides an up-to-date overview of the multi-faceted research on the role of conical intersections in photochemistry and photobiology, including basic theoretical concepts, novel computational strategies as well as innovative experiments. The contents and discussions will be of value to advanced students and researchers in photochemistry, molecular spectroscopy and related areas.

Covers all major modifications, including phosphorylation, glycosylation, acetylation, ubiquitination, sulfonation and and glycation Discussion of the chemistry behind each modification, along with key methods and references Contributions from some of the leading researchers in the field A valuable reference source for all laboratories undertaking proteomics, mass spectrometry and post-translational modification research

Optical Interactions in Solids presents an extensive and unified treatment of the basic principles of the optical properties of solids. It provides a theoretical background to workers in the field of laser physics and absorption and fluorescence spectroscopy of solid state materials. The book is a comprehensive coverage of the subject and is systematically and didactically organized. The level of presentation is such that it will benefit and interest both advanced students and research workers. Group theory — which is useful throughout — is introduced early in the book advocating the scientific community to overcome the reluctance to employ this powerful method. Consistent emphasis is given throughout the book to the relevance of symmetry and to detailed calculations. Different subjects as various as quantum theory of radiation field, thermal vibrations of molecules and crystals and covalent bonding are brought together in a unified treatment which requires knowledge of all these topics and this points to the interpretation of the spectral properties of solids. The content of this work could be used as a two term graduate course in solid state spectroscopy.

An informative and comprehensive book on the applications and techniques of dried blood spot sampling

Dried blood spot (DBS) sampling involves the collection of a small volume of blood, via a simple prick or other means, from a study subject onto a cellulose or polymer paper card, which is followed by drying and transfer to the laboratory for analysis. For many years, this method of blood sample collection has been extensively utilized in some important areas of human healthcare (for example, newborn screening for inherited metabolic disorders and HIV-related epidemiological studies). Because of its advantages over conventional blood, plasma, or serum sample collection, DBS sampling has been valued by the pharmaceutical industry in drug research and development.

Dried Blood Spots: Applications and Techniques features contributions from an international team of leading scientists in the field. Their contributions present a unique resource on the history, principles, procedures, methodologies, applications, and emerging technologies related to DBS.

Presented in three parts, the book thoroughly examines:

Applications of DBS sampling and associated procedures and methodologies in various human healthcare studies Applications and perspectives of DBS sampling in drug research and development, and therapeutic drug monitoring New technologies and emerging applications related to DBS sampling and analysis

Dried Blood Spots: Applications and Techniques is a valuable working guide for researchers, professionals, and students in healthcare, medical science, diagnostics, clinical chemistry, and pharmaceuticals, etc.

Written by a field insider with over 20 years experience in product development, application support, and field marketing for an ICP-MS manufacturer, the third edition of Practical Guide to ICP-MS: A Tutorial for Beginners provides an updated reference that was written specifically with the novice in mind. It presents a compelling story about ICP-MS and what it has to offer, showing this powerful ultra trace-element technique in the way it was intended—a practical solution to real-world problems.

New to the third edition:

New chapter: Emerging ICP-MS Application Areas – covers the three most rapidly growing areas: analysis of flue gas desulfurization wastewaters, fully automated analysis of seawater samples using online chemistry procedures, and characterization of engineered nanoparticles Discussion of all the new technology commercialized since the second edition. An updated glossary of terms with more than 100 new entries Examination of nonstandard sampling accessories, which are important for enhancing the practical capabilities of ICP-MS Insight into additional applications in the environmental, clinical/biomedical, and food chemistry fields as well as new directives from the United States Pharmacopeia (USP) on determining impurities in pharmaceuticals and dietary supplements using Chapters , and Description of the most important analytical factors for selecting an ICP-MS system, taking into consideration more recent application demands

This reference describes the principles and application benefits of ICP-MS in a clear manner for laboratory managers, analytical chemists, and technicians who have limited knowledge of the technique. In addition, it offers much-needed guidance on how best to evaluate capabilities and compare with other trace element techniques when looking to purchase commercial ICP-MS instrumentation.

The book is devoted to three types of laser-based spectroscopy of minerals, namely Laser-Induced Time-Resolved Luminescence, Laser-Induced Breakdown spectroscopy and Gated Raman Spectroscopy. This new edition presents the main new data, which have been received after the publication of the first edition ten years ago both by the authors and by other researchers. During this time, only the authors published more than 50 original papers devoted to laser-based spectroscopy of minerals. A lot of new data have been accumulated, both in fundamental and applied aspects, which are presented in new edition.

The First Book on CRS Microscopy

Compared to conventional Raman microscopy, coherent Raman scattering (CRS) allows label-free imaging of living cells and tissues at video rate by enhancing the weak Raman signal through nonlinear excitation. Edited by pioneers in the field and with contributions from a distinguished team of experts, Coherent Raman Scattering Microscopy explains how CRS can be used to obtain a point-by-point chemical map of live cells and tissues.

In color throughout, the book starts by establishing the foundation of CRS microscopy. It discusses the principles of nonlinear optical spectroscopy, particularly coherent Raman spectroscopy, and presents the theories of contrast mechanisms pertinent to CRS microscopy. The text then provides important technical aspects of CRS microscopy, including microscope construction, detection schemes, and data analyses. It concludes with a survey of applications that demonstrate how CRS microscopy has become a valuable tool in biomedicine.

Due to its label-free, noninvasive examinations of living cells and organisms, CRS microscopy has opened up exciting prospects in biology and medicine—from the mapping of 3D distributions of small drug molecules to identifying tumors in tissues. An in-depth exploration of the theories, technology, and applications, this book shows how CRS microscopy has impacted human health and will deepen our understanding of life processes in the future.

NMR spectroscopy is the most valuable and versatile analytical tool in chemistry. While excellent monographs exist on high-resolution NMR in liquids and solids, this is the first book to address multidimensional solid-state NMR. Multidimensional techniques enable researchers to obtain detailed information about the structure, dynamics, orientation, and phase separation of solids, which provides the basis of a better understanding of materials properties on the molecular level.Dramatic progress-much of it pioneered by the authors-has been achieved in this area, especially in synthetic polymers. Solid-state NMR now favorably competes with well-established techniques, such as light, x-ray, or neutron scattering, electron microscopy, and dielectric and mechanical relaxation.
The application of multidimensional solid-state NMR inevitably involves use of concepts from different fields of science. This book also provides the first comprehensive treatment of both the new experimental techniques and the theoretical concepts needed in more complex data analysis. The text addresses spectroscopists and polymer scientists by treating the subject on different levels; descriptive, technical, and mathematical approaches are used when appropriate. It presents an overview of new developments with numerous experimental examples and illustrations, which will appeal to readers interested in both the information content as well as the potential of solid-state NMR. The book also contains many previously unpublished details that will be appreciated by those who want to perform the experiments. The techniques described are applicable not only to the study of synthetic polymers but to numerous problems in solid-state physics, chemistry, materials science, and biophysics.Presents original theories and new perspectives on scattering techniquesProvides a systematic treatment of the whole subjectGives readers access to previously unpublished materialIncludes extensive illustrations

Chemometrics in Spectroscopy builds upon the statistical information covered in other books written by these leading authors in the field by providing a broader range of mathematics and progressing into the fundamentals of multivariate and experimental data analysis. Subjects covered in this work include: matrix algebra, analytic geometry, experimental design, calibration regression, linearity, design of collaborative laboratory studies, comparing analytical methods, noise analysis, use of derivatives, analytical accuracy, analysis of variance, and much more are all part of this chemometrics compendium. Developed in the form of a tutorial offering a basic hands-on approach to chemometric and statistical analysis for analytical scientists, experimentalists, and spectroscopists. Without using complicated mathematics, Chemometrics in Spectroscopy demonstrates the basic principles underlying the use of common experimental, chemometric, and statistical tools. Emphasis has been given to problem-solving applications and the proper use and interpretation of data used for scientific research.Offers basic hands-on approach to chemometric and statistical analysis for analytical scientists, experimentalists, and spectroscopistsUseful for analysts in their daily problem solving, as well as detailed insights into subjects often considered difficult to thoroughly grasp by non-specialistsProvides mathematical proofs and derivations for the student or rigorously-minded specialist

This book provides information on the techniques needed to analyze foods in laboratory experiments. All topics covered include information on the basic principles, procedures, advantages, limitations, and applications. This book is ideal for undergraduate courses in food analysis and is also an invaluable reference to professionals in the food industry. General information is provided on regulations, standards, labeling, sampling and data handling as background for chapters on specific methods to determine the chemical composition and characteristics of foods. Large, expanded sections on spectroscopy and chromatography also are included. Other methods and instrumentation such as thermal analysis, ion-selective electrodes, enzymes, and immunoassays are covered from the perspective of their use in the analysis of foods. A website with related teaching materials is accessible to instructors who adopt the textbook.

The third edition of this established classic text reference builds upon the strengths of its very popular predecessors. Organized as a broadly useful textbook Principles of Fluorescence Spectroscopy, 3rd edition maintains its emphasis on basics, while updating the examples to include recent results from the scientific literature. The third edition includes new chapters on single molecule detection, fluorescence correlation spectroscopy, novel probes and radiative decay engineering. Includes a link to Springer Extras to download files reproducing all book artwork, for easy use in lecture slides. This is an essential volume for students, researchers, and industry professionals in biophysics, biochemistry, biotechnology, bioengineering, biology and medicine.

Protein NMR Spectroscopy, Second Edition combines a comprehensive theoretical treatment of NMR spectroscopy with an extensive exposition of the experimental techniques applicable to proteins and other biological macromolecules in solution.

Beginning with simple theoretical models and experimental techniques, the book develops the complete repertoire of theoretical principles and experimental techniques necessary for understanding and implementing the most sophisticated NMR experiments.

Important new techniques and applications of NMR spectroscopy have emerged since the first edition of this extremely successful book was published in 1996. This updated version includes new sections describing measurement and use of residual dipolar coupling constants for structure determination, TROSY and deuterium labeling for application to large macromolecules, and experimental techniques for characterizing conformational dynamics. In addition, the treatments of instrumentation and signal acquisition, field gradients, multidimensional spectroscopy, and structure calculation are updated and enhanced.

The book is written as a graduate-level textbook and will be of interest to biochemists, chemists, biophysicists, and structural biologists who utilize NMR spectroscopy or wish to understand the latest developments in this field.

Provides an understanding of the theoretical principles important for biological NMR spectroscopyDemonstrates how to implement, optimize and troubleshoot modern multi-dimensional NMR experimentsAllows for the capability of designing effective experimental protocols for investigations of protein structures and dynamicsIncludes a comprehensive set of example NMR spectra of ubiquitin provides a reference for validation of experimental methods

TEXT BOOK MOLECULAR SPECTRA and MOLECULAR STRUCTURE I. SPECTRA OF DIATOMIC MOLECULES by GERHARD HERZBERG. Originally published in 1939. PREFACE: Eleven years ago I published a volume entitled Molecular Spectra and Molecular Structure I. Diatomic Molecules which was followed in 1945 by a second volume Infrared and Raman Spectra of Polyatomic Molecules. The first volume has been out of print for a number of years but the demand for it seemed to justify a new edition. Although the book has been completely revised and brought up to date, its general plan has remained substantially unchanged. Concerning this plan it seems therefore appropriate to quote from the preface of the first edition I have endeavored to give a presentation which is readable by the beginner in the field and also will be useful to those who do or want to do research work in this field. In order to assist the former, I have frequently made use of small type for those sections that are not necessary for an understanding of the fundamentals. For the benefit of those working in the field, numerous references to original papers have been included. A satisfactory presentation of molecular spectra and molecular structure is nowadays not possible without treating thoroughly, apart from the empirical results, the theoretical background also. Therefore I have included as much of the theory of molecular spectra as is possible without going into the more difficult mathematical details. A large number of diagrams, graphical repre sentations of eigenfunctions and potential curves, as well as energy level dia grams, serve to illustrate and to explain the theory. On the other hand, I have added numerous carefully selected spectrograms of bands and band systems some of which have been taken specially for this purpose in order to give an accurate idea of tho experimental material that forms the basis of the developments. While of course most of the material presented is not new, it seems that the actual procedure followed in analyzing a band spectrum has not previously been given as specifically in a book of this kind. The same holds for the ap plications of band spectra to other parts of physics, to chemistry, and to astro physics given in the last chapter. I hope that both these features will be found useful. In the eleven years since the publication of the first edition the subject Spectra of Diatomic Molecules has developed vigorously even though not as rapidly as in the preceding two decades. Most of the progress made has been consolidation and slow evolution rather than revolution. Exceptions to this statement are the amazing advances made by applying the new tools of molecular beams and microwaves to diatomic molecular problems. Naturally I have incorporated these advances of recent years in the present new edition...

Supercritical Fluid Extraction is a technique in which CO2 is used under extremely high pressure to separate solution (e.g., removing caffeine from coffee). Separations is basic to all process industries and supercritical fluid extraction is a specific type which is receiving a high level of attention. The book will combine basic fundamentals with industrial applications. The second edition has been expanded and updated and includes new chapters on chromatography and food processing.

"...this is an excellent book which is both instructive and amusing to read. Its true value is neatly summarised in one of the closing sentences: 'We have supplied you with the guidelines and criteria which you can now apply when considering supercritical fluids for your own needs.'' - Chemistry in Britain, February 1995

This expanded edition introduces new design methods and is packed with examples, design charts, tables, and performance diagrams to add to the practical understanding of how selected equipment can be expected to perform in the process situation. A major addition is the comprehensive chapter on process safety design considerations, ranging from new devices and components to updated venting requirements for low-pressure storage tanks to the latest NFPA methods for sizing rupture disks and bursting panels, and more.



*Completely revised and updated throughout

*The definative guide for process engineers and designers

*Covers a complete range of basic day-to-day operation topics

PRINCIPLES OF INSTRUMENTAL ANALYSIS is the standard for courses on the principles and applications of modern analytical instruments. In the 7th edition, authors Skoog, Holler, and Crouch infuse their popular text with updated techniques and several new Instrumental Analysis in Action case studies. Updated material enhances the book's proven approach, which places an emphasis on the fundamental principles of operation for each type of instrument, its optimal area of application, its sensitivity, its precision, and its limitations. The text also introduces students to elementary analog and digital electronics, computers, and the treatment of analytical data.
Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Grating Spectroscopes and How to Use Them is written for amateur astronomers who are just getting into this field of astronomy. Transmission grating spectroscopes look like simple filters and are designed to screw into place on the eyepiece of a telescope for visual use, or into the camera adapter for digicam or CCD imaging. Using the most popular commercially made filter gratings – Rainbow Optics (US) and Star Analyzer (UK) – as examples, this book provides the reader with information on how to set up and use the grating one needs to obtain stellar spectrograms. It also discusses several methods on analyzing the results. This book is written in an easy to read style, perfect for getting started on the first night using the spectroscope, and specifically showing how the simple transmission filter is used on the camera or telescope. No heavy mathematics or formulas are involved, and there are many practical hints and tips – something that is almost essential to success when starting out. This book helps readers to achieve quick results, and by following the worked examples, they can successfully carry out basic analysis of the spectra.

Flow Analysis (FA) offers a very convenient and fast approach to enhance and automate 'preliminary steps' of analysis (sample dissolution, pretreatments, preconcentrations, etc.) for atomic spectrometric detectors (ASD). Moreover, flow manifolds can ease the well-known problem of sample introduction/presentation to atomisers or even expand the classical scope of atomic/elemental information, characterizing atomic spectrometry, into the realm of molecules and metal-compounds analysis (e.g. by resorting to coupled separation techniques). All these facts could explain both the extraordinary interest for research and the great importance for practical problem-solving achieved nowadays by FA-ASD.

On the threshold of the new millennium when plasma emission and mass spectrometry are so important and popular, the editor considered it timely to produce a book which covers all present atomic detectors and techniques where FA has been or can be advantageously employed. The book has been conceived in three separate parts: Part I gives the fundamental, instrumentation and potential of FIA as a most versatile sample presentation/introduction system for atomic spectrometry. Part II provides a modern account of fundamentals, possibilities and applications offered by flow analysis to atomic spectrometry for on-line sample pretreatments, separations and preconcentrations. Part III deals with applications of FA-ASD combinations to analytical problem-solving in most varied fields and situations.

This monograph integrates the most popular aspects of FIA, its new developments for sample on-line treatments and on-line non-chromatographic and chromatographic separations (all typical 'flow analysis') in connection with all branches of analytical atomic spectrometry. Thus, academics, researchers and routine users of analytical atomic spectrometry will find this book invaluable.

X-ray fluorescence spectroscopy, one of the most powerful and flexible techniques available for the analysis and characterization of materials today, has gone through major changes during the past decade.
Fully revised and expanded by 30%, X-Ray Fluorescence Spectrometry, Second Edition incorporates the latest industrial and scientific trends in all areas. It updates all previous material and adds new chapters on such topics as the history of X-ray fluorescence spectroscopy, the design of X-ray spectrometers, state-of-the-art applications, and X-ray spectra.
Ron Jenkins draws on his extensive experience in training and consulting industry professionals for this clear and concise treatment, covering first the basic aspects of X rays, then the methodology of X-ray fluorescence spectroscopy and available instrumentation. He offers a comparison between wavelength and energy dispersive spectrometers as well as step-by-step guidelines to X-ray spectrometric techniques for qualitative and quantitative analysis-from specimen preparation to real-world industrial application.
Favored by the American Chemical Society and the International Centre for Diffraction Data, X-Ray Fluorescence Spectrometry, Second Edition is an ideal introduction for newcomers to the field and an invaluable reference for experienced spectroscopists-in chemical analysis, geology, metallurgy, and materials science.
An up-to-date review of X-ray spectroscopic techniques. This proven guidebook for industry professionals is thoroughly updated and expanded to reflect advances in X-ray analysis over the last decade. X-Ray Fluorescence Spectrometry, Second Edition includes:
* The history of X-ray fluorescence spectrometry-new to this edition.
* A critical review of the most useful X-ray spectrometers.
* Techniques and procedures for quantitative and qualitative analysis.
* Modern applications and industrial trends.
* X-ray spectra-new to this edition.

If you investigate biological systems and might use mass spectrometry in your research but need to know more about it, this book is for you. It introduces the fundamental concepts of mass spectrometry and how mass spectrometers work. It also presents recent advancements particularly interesting to bio-researchers in an easy-to-understand manner that does not require extensive background in chemistry, math, or physics.Glossary of basic termsAbundant illustrationsExamples of applicationsPractical tips on using mass spectrometric techniquesUseful for peptide, protein, oligonucleotide, and carbohydrate analysisSimplified description of mass spectrometry including: Matrix-Assisted Laser Desorption/Ionization (MALDI)Electrospray Ionization (ESI)Fast Atom/Ion Bombardment (FAB)

IR spectroscopy has become without any doubt a key technique to answer questions raised when studying the interaction of proteins or peptides with solid surfaces for a fundamental point of view as well as for technological applications.

Principle, experimental set ups, parameters and interpretation rules of several advanced IR-based techniques; application to biointerface characterisation through the presentation of recent examples, will be given in this book. It will describe how to characterise amino acids, protein or bacterial strain interactions with metal and oxide surfaces, by using infrared spectroscopy, in vacuum, in the air or in an aqueous medium. Results will highlight the performances and perspectives of the technique.

Description of the principles, expermental setups and parameter interpretation, and the theory for several advanced IR-based techniques for interface characterisationContains examples which demonstrate the capacity, potential and limits of the IR techniquesHelps finding the most adequate mode of analysisContains examplesContains a glossary by techniques and by keywords

This encyclopaedic catalogue of the pitfalls and problems that all analysts encounter in their work is destined to spend more time on the analyst's workbench than on a library shelf. The author has dedicated the book to ``the innumerable scientists who made mistakes, used impure chemicals and solvents, suffered the consequences of unanticipated side-reactions, and were otherwise exposed to mayhem yet were not too embarrassed to publish their findings''. Traditionally, the mass spectroscopist or gas chromatographer learnt his trade by participating in a 4-6 year apprenticeship as graduate student and post-doctoral researcher. Generally, no formal training was provided on the things that go wrong, but this information was accumulated by sharing in the experiences of colleagues. Nowadays, many novice scientists simply purchase a computerized instrument, plug it in, and use it. Much time can be wasted in studying and resolving problems due to artifacts and there is also a strong possibility that artifacts will not be recognized as such. For example, most analysts realize that they should use glass rather than plastic containers; but few of them would anticipate the possibility of plasticizer residues on glassware washed using detergent from a plastic bottle.

This book is an easy-to-use compendium of problems encountered when using various commonly used analytical techniques. Emphasis is on impurities, by-products, contaminants and other artifacts. A separate entry is provided for each artifact. For specific chemicals, this entry provides the common name, mass spectrum, gas chromatographic data, CAS name and registry number, synonyms and a narrative discussion. More than 1100 entries are included. Mass spectral data are indexed in a 6-peak index (molecular ion, base peak, second peak, third peak) and there are also formula, author and subject indexes. An extensive bibliography contains complete literature citations.

The book is designed to be used. It will not only allow experienced analysts to profit from the mistakes of others, but it will also be invaluable to other scientists who use analytical instruments in their work.

NMR Spectroscopy Explained : Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology provides a fresh, practical guide to NMR for both students and practitioners, in a clearly written and non-mathematical format. It gives the reader an intermediate level theoretical basis for understanding laboratory applications, developing concepts gradually within the context of examples and useful experiments. Introduces students to modern NMR as applied to analysis of organic compounds. Presents material in a clear, conversational style that is appealing to students. Contains comprehensive coverage of how NMR experiments actually work. Combines basic ideas with practical implementation of the spectrometer. Provides an intermediate level theoretical basis for understanding laboratory experiments. Develops concepts gradually within the context of examples and useful experiments. Introduces the product operator formalism after introducing the simpler (but limited) vector model.

This book describes the use of NMR spectroscopy for dealing with problems of small organic molecule structural elucidation. It features a significant amount of vital chemical shift and coupling information but more importantly, it presents sound principles for the selection of the techniques relevant to the solving of particular types of problem, whilst stressing the importance of extracting the maximum available information from the simple 1-D proton experiment and of using this to plan subsequent experiments. Proton NMR is covered in detail, with a description of the fundamentals of the technique, the instrumentation and the data that it provides before going on to discuss optimal solvent selection and sample preparation. This is followed by a detailed study of each of the important classes of protons, breaking the spectrum up into regions (exchangeables, aromatics, heterocyclics, alkenes etc.). This is followed by consideration of the phenomena that we know can leave chemists struggling; chiral centres, restricted rotation, anisotropy, accidental equivalence, non-first-order spectra etc.  Having explained the potential pitfalls that await the unwary, the book then goes on to devote chapters to the chemical techniques and the most useful instrumental ones that can be employed to combat them.

A discussion is then presented on carbon-13 NMR, detailing its pros and cons and showing how it can be used in conjunction with proton NMR via the pivotal 2-D techniques (HSQC and HMBC) to yield vital structural information. Some of the more specialist techniques available are then discussed, i.e. flow NMR, solvent suppression, Magic Angle Spinning, etc. Other important nuclei are then discussed and useful data supplied. This is followed by a discussion of the neglected use of NMR as a tool for quantification and new techniques for this explained. The book then considers the safety aspects of NMR spectroscopy, reviewing NMR software for spectral prediction and data handling and concludes with a set of worked Q&As.

The Second Edition of Practical Gamma-Ray Spectrometry has been completely revised and updated, providing comprehensive coverage of the whole gamma-ray detection and spectrum analysis processes. Drawn on many years of teaching experience to produce this uniquely practical volume, issues discussed include the origin of gamma-rays and the issue of quality assurance in gamma-ray spectrometry. This new edition also covers the analysis of decommissioned nuclear plants, computer modelling systems for calibration, uncertainty measurements in QA, and many more topics.

Environmental forensics is emerging and evolving into a recognized scientific discipline with numerous applications, especially regarding chlorinated solvents. This unique book provides the reader with a concise compilation of information regarding the use of environmental forensic techniques for age dating and identification of the source of a chlorinated solvent release. Concentrating on the five commonly encountered chlorinated solvents (perchloroethylene, trichloroethylene, methyl chloroform, carbon tetrachloride and CFC-113), forensic opportunities applicable to each are presented including the use of stabilizers, manufacturing impurities, surrogate chemicals and physical measurements and degradation products as diagnostic indicators. Detailed historical chronology of the applications of the solvents and specific chapters devoted to dry cleaning and vapor degreasing equipment are included as are generic forensic approaches. Forming a basis for further ideas in the evolution of environmental forensic techniques, Chlorinated Solvents will be an indispensable reference tool for researchers, regulators and analysts in the field.

This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development.

Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.

Known for its readability and systematic, rigorous approach, this fully updated Ninth Edition of FUNDAMENTALS OF ANALYTICAL CHEMISTRY offers extensive coverage of the principles and practices of analytic chemistry and consistently shows students its applied nature. The book's award-winning authors begin each chapter with a story and photo of how analytic chemistry is applied in industry, medicine, and all the sciences. To further reinforce student learning, a wealth of dynamic photographs by renowned chemistry photographer Charlie Winters appear as chapter-openers and throughout the text. Incorporating Excel spreadsheets as a problem-solving tool, the Ninth Edition is enhanced by a chapter on Using Spreadsheets in Analytical Chemistry, updated spreadsheet summaries and problems, an Excel Shortcut Keystrokes for the PC insert card, and a supplement by the text authors, EXCEL APPLICATIONS FOR ANALYTICAL CHEMISTRY, which integrates this important aspect of the study of analytical chemistry into the book's already rich pedagogy. New to this edition is OWL, an online homework and assessment tool that includes the Cengage YouBook, a fully customizable and interactive eBook, which enhances conceptual understanding through hands-on integrated multimedia interactivity. Available with InfoTrac Student Collections http://gocengage.com/infotrac.
Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities.
Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine.

The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging.

* Provides a broad look at how the medical field is benefiting from advances in mass spectrometry.
* Guides the reader from basic principles and methods to cutting edge applications.
* There is NO comparable book on the market to fill this fast growing field.

This book introduces readers interested in the field of X-ray Photoelectron Spectroscopy (XPS) to the practical concepts in this field. The book first introduces the reader to the language and concepts used in this field and then demonstrates how these concepts are applied. Including how the spectra are produced, factors that can influence the spectra (all initial and final state effects are discussed), how to derive speciation, volume analysed and how one controls this (includes depth profiling), and quantification along with background substraction and curve fitting methodologies.

 

This is presented in a concise yet comprehensive manner and each section is prepared such that they can be read independently of each other, and all equations are presented using the most commonly used units. Greater emphasis has been placed on spectral understanding/interpretation. For completeness sake, a description of commonly used instrumentation is also presented. Finally, some complementary surface analytical techniques and associated concepts are reviewed for comparative purposes in stand-alone appendix sections.

The use of lasers which emit infra-red radiation and sophisticated detectors of IR radiation is increasing dramatically: they are being used for long-distance fibre-optic communications and remote environmental monitoring and sensing. Thus they are of interest to the telecommunications industry and the military in particular. This book has been designed to bring together what is known on these devices, using an international group of contributors.

Designed to serve as a textbook for postgraduate students of physics and chemistry, this second edition improves the clarity of treatment, extends the range of topics, and includes more worked examples with a view to providing all the material needed for a course in molecular spectroscopy—from first principles to the very useful spectral data that comprise figures, charts and tables. To improve the conceptual appreciation and to help students develop more positive and realistic impressions of spectroscopy, there are two new chapters—one on the spectra of atoms and the other on laser spectroscopy. The chapter on the spectra of atoms is a detailed account of the basic principles involved in molecular spectroscopy. The chapter on laser spectroscopy covers some new experimental techniques for the investigation of the structure of atoms and molecules. Additional sections on interstellar molecules, inversion vibration of ammonia molecule, fibre-coupled Raman spectrometer, Raman microscope, supersonic beams and jet-cooling have also been included. Besides worked-out examples, an abundance of review questions, and end-of-chapter problems with answers are included to aid students in testing their knowledge of the material contained in each chapter. Solutions manual containing the complete worked-out solutions to chapter-end problems is available for instructors.

Instant Notes in Analytical Chemistry provides students with a thorough comprehension of analytical chemistry and its applications. It supports the learning of principles and practice of analytical procedures and also covers the analytical techniques commonly used in laboratories today.

Indicators offers a comprehensive account of indicators and their applications in areas such as titrimetric analysis and the analysis of mineral waters. The theory and principles of visual indicators are discussed, along with acid-base indicators, indicators for non-aqueous acid-base titrations, and titrations with non-chelating ligands. Metallochromic indicators, adsorption indicators, oxidation-reduction indicators, and fluorescent and chemiluminescent indicators are also considered.
This volume is comprised of 10 chapters and begins with a brief history of indicators, including the contribution of Robert Boyle in the field. The different kinds of indicators are also described, along with developments in indicators in the nineteenth century. The next chapter deals with the theory and principles of visual indicators, followed by a discussion on acid-base indicators such as organic dyes, inorganic substances, compounds capable of fluorescence, and chemiluminescent systems. Subsequent chapters explore other varieties of indicators, including indicators for non-aqueous acid-base titrations, metallochromic indicators, and adsorption indicators, as well as oxidation-reduction indicators and fluorescent and chemiluminescent indicators.
This book will be of interest to chemists.

Write Like a Chemist is a unique guide to chemistry-specific writing. Written with National Science Foundation support and extensively piloted in chemistry courses nationwide, it offers a structured approach to writing that targets four important chemistry genres: the journal article, conference abstract, scientific poster, and research proposal. Chemistry students, post-docs, faculty, and other professionals interested in perfecting their disciplinary writing will find it an indispensable reference. Users of the book will learn to write through a host of exercises, ranging in difficulty from correcting single words and sentences to writing professional-quality papers, abstracts, posters, and proposals. The book's read-analyze-write approach teaches students to analyze what they read and then write, paying attention to audience, organization, writing conventions, grammar, and science content, thereby turning the complex process of writing into graduated, achievable tasks. Concise writing and organizational skills are stressed throughout, and "move structures" teach students conventional ways to present their stories of scientific discovery. This resource includes over 350 excerpts from ACS journal articles, ACS conference abstracts, and successful NSF CAREER proposals, excerpts that will serve as useful models of chemistry writing for years to come. Other special features: Usable in chemistry lab, lecture, and writing-dedicated courses Useful as a writing resource for practicing chemists Augmented by Language Tips that address troublesome areas of language and grammer in a self-study format Accompanied by a Web site: http://www.oup.com/us/writelikeachemist Supplemented with an answer key for faculty adopting the book

Crucial to research in molecular biology, medicine, geology, food science, materials science, and many other fields, analytical instrumentation is used by many scientists and engineers who are not chemists. Undergraduate Instrumental Analysis, Seventh Edition provides users of analytical instrumentation with an understanding of these instruments, covering all major fields of modern instrumentation. Following the tradition of earlier editions, this text is designed for teaching undergraduates and those with no analytical chemistry background how contemporary analytical instrumentation works, as well as its uses and limitations.

Each chapter provides a discussion of the fundamental principles underlying the techniques, descriptions of the instrumentation, and numerous applications. The chapters also contain updated bibliographies and problems, and most have suggested experiments appropriate to the techniques. This completely revised and updated edition covers subjects in more detail, such as a completely revised x-ray chapter, expanded coverage of electroanalytical techniques, and expansion of chromatography and mass spectrometry topics to reflect the predominance of these instruments in laboratories. This includes state-of-the-art sample introduction and mass analyzers, and the latest developments in UPLC and hyphenated techniques. The book also contains new graphics and addresses several new topics:

Ion mobility spectrometry Time domain NMR (relaxometry) Electron spin resonance spectroscopy (ESR, EPR) Forensic science and bioanalytical applications Microcalorimetry and optical thermal instruments Laser-induced breakdown spectroscopy (LIBS)

This text uniquely combines instrumental analysis with organic spectral interpretation (IR, NMR, and MS). It provides detailed coverage of sampling, sample handling, sample storage, and sample preparation. In addition, the authors have included many instrument manufacturers’ websites, which contain extensive resources.

The second edition of Gas Chromatography and Mass Spectrometry: A Practical Guide follows the highly successful first edition by F.G. Kitson, B.S. Larsen, and C.N. McEwen (1996), which was designed as an indispensible resource for GC/MS practitioners regardless of whether they are a novice or well experienced. The Fundamentals section has been extensively reworked from the original edition to give more depth of an understanding of the techniques and science involved with GC/MS. Even with this expansion, the original brevity and simple didactic style has been retained. Information on chromatographic peak deconvolution has been added along with a more in-depth understanding of the use of mass spectral databases in the identification of unknowns. Since the last edition, a number of advances in GC inlet systems and sample introduction techniques have occurred, and they are included in the new edition. Other updates include a discussion on fast GC and options for combining GC detectors with mass spectrometry.

The section regarding GC Conditions, Derivatization, and Mass Spectral Interpretation of Specific Compound Types has the same number of compound types as the original edition, but the information in each section has been expanded to not only explain some of the spectra but to also explain why certain fragmentations take place. The number of Appendices has been increased from 12 to 17. The Appendix on Atomic Masses and Isotope Abundances has been expanded to provide tools to aid in determination of elemental composition from isotope peak intensity ratios. An appendix with examples on "Steps to follow in the determination of elemental compositions based on isotope peak intensities" has been added. Appendices on whether to use GC/MS or LC/MS, third-party software for use in data analysis, list of information required in reporting GC/MS data, X+1 and X+2 peak relative intensities based on the number of atoms of carbon in an ion, and list of available EI mass spectral databases have been added. Others such as the ones on derivatization, isotope peak patterns for ions with Cl and/or Br, terms used in GC and in mass spectrometry, and tips on setting up, maintaining and troubleshooting a GC/MS system have all been expanded and updated.

Covers the practical instruction necessary for successful operation of GC/MS equipmentReviews the latest advances in instrumentation, ionization methods, and quantitationIncludes troubleshooting techniques and a variety of additional information useful for the GC/MS practitionerA true benchtop referenceA guide to a basic understanding of the components of a Gas Chromatograph-Mass Spectrometer (GC-MS)Quick References to data interpretationReady source for information on new analyses

Introduce your students to the latest advances in spectroscopy with the text that has set the standard in the field for more than three decades: INTRODUCTION TO SPECTROSCOPY, 5e, by Donald L. Pavia, Gary M. Lampman, George A. Kriz, and James R. Vyvyan. Whether you use the book as a primary text in an upper-level spectroscopy course or as a companion book with an organic chemistry text, your students will receive an unmatched, systematic introduction to spectra and basic theoretical concepts in spectroscopic methods. This acclaimed resource features up-to-date spectra; a modern presentation of one-dimensional nuclear magnetic resonance (NMR) spectroscopy; an introduction to biological molecules in mass spectrometry; and coverage of modern techniques alongside DEPT, COSY, and HECTOR.
Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Practical approaches to ensure that analytical methods and instruments meet GMP standards and requirements

Complementing the authors' first book, Analytical Method Validation and Instrument Performance Verification, this new volume provides coverage of more advanced topics, focusing on additional and supplemental methods, instruments, and electronic systems that are used in pharmaceutical, biopharmaceutical, and clinical testing. Readers will gain new and valuable insights that enable them to avoid common pitfalls in order to seamlessly conduct analytical method validation as well as instrument operation qualification and performance verification.

Part 1, Method Validation, begins with an overview of the book's risk-based approach to phase appropriate validation and instrument qualification; it then focuses on the strategies and requirements for early phase drug development, including validation of specific techniques and functions such as process analytical technology, cleaning validation, and validation of laboratory information management systems

Part 2, Instrument Performance Verification, explores the underlying principles and techniques for verifying instrument performance—coverage includes analytical instruments that are increasingly important to the pharmaceutical industry, such as NIR spectrometers and particle size analyzers—and offers readers a variety of alternative approaches for the successful verification of instrument performance based on the needs of their labs

At the end of each chapter, the authors examine important practical problems and share their solutions. All the methods covered in this book follow Good Analytical Practices (GAP) to ensure that reliable data are generated in compliance with current Good Manufacturing Practices (cGMP).

Analysts, scientists, engineers, technologists, and technical managers should turn to this book to ensure that analytical methods and instruments are accurate and meet GMP standards and requirements.

Providing a roadmap from early to late stages of drug development, this book overviews amorphous solid dispersion technology – a leading platform to deliver poorly water soluble drugs, a major hurdle in today’s pharmaceutical industry.

• Helps readers understand amorphous solid dispersions and apply techniques to particular pharmaceutical systems
• Covers physical and chemical properties, screening, scale-up, formulation, drug product manufacture, intellectual property, and regulatory considerations
• Has an appendix with structure and property information for polymers commonly used in drug development and with marketed drugs developed using the amorphous sold dispersion approach
• Addresses global regulatory issues including USA regulations, ICH guidelines, and patent concerns around the world

Practical NMR Spectroscopy Laboratory Guide is designed to provide non-expert NMR users, typically graduate students in chemistry, an introduction to various facets of practical solution-state NMR spectroscopy. Each chapter offers a series of hands-on exercises, introducing various NMR concepts and experiments and guiding the reader in running these experiments using an NMR spectrometer. The book is written for use with a Bruker NMR spectrometer running TopSpin software versions 1 or 2. This practical resource functions both as a text for instructors of a practical NMR course and also as a reference for spectrometer administrators or NMR facility directors when doing user training. This guide serves as serve as excellent, practical resource on its own or as a companion book to Timothy Claridge’s High-Resolution NMR Techniques in Organic Chemistry, 2nd Edition (Elsevier, 2009).Written by experts in solution-state NMR spectroscopyProvides step-by-step instructions for more than 50 activities using a Bruker NMR spectrometerIncludes detailed appendices and sample questions for lab reports

Biological Inorganic Chemistry: A New Introduction to Molecular Structure and Function, Second Edition, provides a comprehensive discussion of the biochemical aspects of metals in living systems.
Beginning with an overview of metals and selected nonmetals in biology, the book then discusses the following concepts: basic coordination chemistry for biologists; structural and molecular biology for chemists; biological ligands for metal ions; intermediary metabolism and bioenergetics; and methods to study metals in biological systems.
The book also covers metal assimilation pathways; transport, storage, and homeostasis of metal ions; sodium and potassium channels and pumps; magnesium phosphate metabolism and photoreceptors; calcium and cellular signaling; the catalytic role of several classes of mononuclear zinc enzymes; the biological chemistry of iron; and copper chemistry and biochemistry. In addition, the book discusses nickel and cobalt enzymes; manganese chemistry and biochemistry; molybdenum, tungsten, vanadium, and chromium; non-metals in biology; biomineralization; metals in the brain; metals and neurodegeneration; metals in medicine and metals as drugs; and metals in the environment.Winner of a 2013 Textbook Excellence Awards (Texty) from the Text and Academic Authors AssociationReadable style, complemented by anecdotes and footnotesEnables the reader to more readily grasp the biological and clinical relevance of the subjectColor illustrations enable easy visualization of molecular mechanisms