Organic Structures from Spectra, Fifth Edition is a carefully chosen set of more than 280 structural problems employing the major modern spectroscopic techniques, a selection of 27 problems using 2D-NMR spectroscopy, more than 20 problems specifically dealing with the interpretation of spin-spin coupling in proton NMR spectra and 8 problems based on the quantitative analysis of mixtures using proton and carbon NMR spectroscopy. All of the problems are graded to develop and consolidate the student’s understanding of organic spectroscopy. The accompanying text is descriptive and only explains the underlying theory at a level which is sufficient to tackle the problems. The text includes condensed tables of characteristic spectral properties covering the frequently encountered functional groups.
The examples themselves have been selected to include all important common structural features found in organic compounds and to emphasise connectivity arguments. Many of the compounds were synthesised specifically for this purpose. There are many more easy problems, to build confidence and demonstrate basic principles, than in other collections.
The fifth edition of this popular textbook:
• includes more than 250 new spectra and more than 25 completely new problems;
• now incorporates an expanded suite of new problems dealing with the analysis of 2D NMR spectra (COSY, C H Correlation spectroscopy, HMBC, NOESY and TOCSY);
• has been expanded and updated to reflect the new developments in NMR and to retire older techniques that are no longer in common use;
• provides a set of problems dealing specifically with the quantitative analysis of mixtures using NMR spectroscopy;
• features proton NMR spectra obtained at 200, 400 and 600 MHz and 13C NMR spectra include DEPT experiments as well as proton-coupled experiments;
• contains 6 problems in the style of the experimental section of a research paper and two examples of fully worked solutions.
Organic Structures from Spectra, Fifth Edition will prove invaluable for students of Chemistry, Pharmacy and Biochemistry taking a first course in Organic Chemistry.
Nuclear Magnetic Resonance Spectroscopy
Reviews from earlier editions
“Your book is becoming one of the “go to” books for teaching structure determination here in the States. Great work!”
“...I would definitely state that this book is the most useful aid to basic organic spectroscopy teaching in existence and I would strongly recommend every instructor in this area to use it either as a source of examples or as a class textbook”.
Magnetic Resonance in Chemistry
“Over the past year I have trained many students using problems in your book - they initially find it as a task. But after doing 3-4 problems with all their brains activities... working out the rest of the problems become a mania. They get addicted to the problem solving and every time they solve a problem by themselves, their confident level also increases.”
“I am teaching the fundamentals of Molecular Spectroscopy and your books represent excellent sources of spectroscopi
Reviews of the First Edition
“For anyone wishing to know what really goes on in their NMR experiments, I would highly recommend this book” – Chemistry World
“...I warmly recommend for budding NMR spectroscopists, or others who wish to deepen their understanding of elementary NMR theory or theoretical tools” – Magnetic Resonance in Chemistry
This book incorporates recent technological advances in analytical pyrolysis methods especially useful for the characterization of 163 typical synthetic polymers. The book briefly reviews the instrumentation available in advanced analytical pyrolysis, and offers guidance to perform effectually this technique combining with gas chromatography and mass spectrometry. Main contents are comprehensive sample pyrograms, thermograms, identification tables, and representative mass spectra (MS) of pyrolyzates for synthetic polymers. This edition also highlights thermally-assisted hydrolysis and methylation technique effectively applied to 33 basic condensation polymers.Coverage of Py-GC/MS data of conventional pyrograms and thermograms of basic 163 kinds of synthetic polymers together with MS and retention index data for pyrolyzates, enabling a quick identificationAdditional coverage of the pyrograms and their related data for 33 basic condensation polymers obtained by the thermally-assisted hydrolysis and methylation techniqueAll compiled data measured under the same experimental conditions for pyrolysis, gas chromatography and mass spectrometry to facilitate peak identificationSurveyable instant information on two facing pages dedicated to the whole data of a given polymer sample
Students in the physical and life sciences, and in engineering, need to know about the physics and biology of light. Recently, it has become increasingly clear that an understanding of the quantum nature of light is essential, both for the latest imaging technologies and to advance our knowledge of fundamental life processes, such as photosynthesis and human vision. From Photon to Neuron provides undergraduates with an accessible introduction to the physics of light and offers a unified view of a broad range of optical and biological phenomena. Along the way, this richly illustrated textbook builds the necessary background in neuroscience, photochemistry, and other disciplines, with applications to optogenetics, superresolution microscopy, the single-photon response of individual photoreceptor cells, and more.
With its integrated approach, From Photon to Neuron can be used as the basis for interdisciplinary courses in physics, biophysics, sensory neuroscience, biophotonics, bioengineering, or nanotechnology. The goal is always for students to gain the fluency needed to derive every result for themselves, so the book includes a wealth of exercises, including many that guide students to create computer-based solutions. Supplementary online materials include real experimental data to use with the exercises.
The section regarding GC Conditions, Derivatization, and Mass Spectral Interpretation of Specific Compound Types has the same number of compound types as the original edition, but the information in each section has been expanded to not only explain some of the spectra but to also explain why certain fragmentations take place. The number of Appendices has been increased from 12 to 17. The Appendix on Atomic Masses and Isotope Abundances has been expanded to provide tools to aid in determination of elemental composition from isotope peak intensity ratios. An appendix with examples on "Steps to follow in the determination of elemental compositions based on isotope peak intensities" has been added. Appendices on whether to use GC/MS or LC/MS, third-party software for use in data analysis, list of information required in reporting GC/MS data, X+1 and X+2 peak relative intensities based on the number of atoms of carbon in an ion, and list of available EI mass spectral databases have been added. Others such as the ones on derivatization, isotope peak patterns for ions with Cl and/or Br, terms used in GC and in mass spectrometry, and tips on setting up, maintaining and troubleshooting a GC/MS system have all been expanded and updated.Covers the practical instruction necessary for successful operation of GC/MS equipmentReviews the latest advances in instrumentation, ionization methods, and quantitationIncludes troubleshooting techniques and a variety of additional information useful for the GC/MS practitionerA true benchtop referenceA guide to a basic understanding of the components of a Gas Chromatograph-Mass Spectrometer (GC-MS)Quick References to data interpretationReady source for information on new analyses
The book assumes only a basic knowledge of complex numbers and matrices, and provides the reader with numerous worked examples and exercises to encourage understanding. With the explicit aim of carefully developing the subject from the beginning, the text starts with coverage of quarks and nucleons and progresses through to a detailed explanation of several important NMR experiments, including NMR imaging, COSY, NOESY and TROSY.
Completely revised and updated, the Second Edition features new material on the properties and distributions of isotopes, chemical shift anisotropy and quadrupolar interactions, Pake patterns, spin echoes, slice selection in NMR imaging, and a complete new chapter on the NMR spectroscopy of quadrupolar nuclei. New appendices have been included on Euler angles, and coherence selection by field gradients. As in the first edition, all material is heavily supported by graphics, much of which is new to this edition.
Written for undergraduates and postgraduate students taking a first course in NMR spectroscopy and for those needing an up-to-date account of the subject, this multi-disciplinary book will appeal to chemical, physical, material, life, medical, earth and environmental scientists. The detailed physical insights will also make the book of interest for experienced spectroscopists and NMR researchers.
• An accessible and carefully written introduction, designed to help students to fully understand this complex and dynamic subject
• Takes a multi-disciplinary approach, focusing on basic principles and concepts rather than the more practical aspects
• Presents a strong pedagogical approach throughout, with emphasis placed on individual spins to aid understanding
• Includes numerous worked examples, problems, further reading and additional notes
Praise from the reviews of the First Edition:
"This is an excellent book... that many teachers of NMR spectroscopy will cherish... It deserves to be a ‘classic’ among NMR spectroscopy texts." NMR IN BIOMEDICINE
"I strongly recommend this book to everyone...it is probably the best modern comprehensive description of the subject." ANGEWANDTE CHEMIE, INTERNATIONAL EDITION
It provides a valuable guide to assist with teaching Raman spectroscopy which is gaining attention in (analytical) chemistry, and as a consequence, teaching programs have followed. Today, education in Raman spectroscopy is often limited to theoretical aspects (e.g. selection rules), but practical aspects are usually disregarded. With these course notes, the author hopes to fill this gap and include information about Raman instrumentation and how it is interpreted.Provides a user-friendly text that tackles the theoretical background, and offers everyday tips for common practice Raman instrumentation and practical aspects, which are sometimes overlooked, are covered Appropriate for students, and includes summaries, text boxes, illustrating the ideas with examples from research literature or providing background information or links with other courses Written with an open-learning approach, this book will be ideal for use as a self-study guide or as the basis of a taught course with discussion and self-assessment questions throughout the text Includes a comprehensive bibliography to guide the reader to more specialized texts and sources.
The book includes a clear explanation of the laboratory theory behind astronomical spectrographs, and goes on to extensively cover the practical application of astronomical spectroscopy in detail. Four popular and reasonably-priced commercially available diffraction grating spectrographs are used as examples. The first is a low-resolution transmission diffraction grating, the Star Analyser spectrograph. The second is an inexpensive fiber optic coupled bench spectrograph that can be used to learn more about spectroscopy. The third is a newcomer, the ALPY 600 spectrograph. The fourth spectrograph considered is at the other end of the market both in performance and cost, the high-resolution Lhires III. While considerably more expensive, this is a popular and excellent scientific instrument, that allows more advanced amateur astronomers to produce scientifically valuable data.
With all of these tools in place, the amateur astronomer is well-prepared to forger deeper into the night sky using spectroscopy.
This multi-disciplined text covers the fundamentals as well as recent advance in this topic, providing need-to-know information for researchers in many disciplines including pharmaceutical, environmental and biomedical analysis who are utilizing mass spectrometry
In this book, you will learn the fundamental principles underpinning molecular spectroscopy and the connections between those principles and the design of spectrophotometers.
Spectroscopy, along with chromatography, mass spectrometry, and electrochemistry, is an important and widely-used analytical technique. Applications of spectroscopy include air quality monitoring, compound identification, and the analysis of paintings and culturally important artifacts. This book introduces students to the fundamentals of molecular spectroscopy – including UV-visible, infrared, fluorescence, and Raman spectroscopy – in an approachable and comprehensive way. It goes beyond the basics of the subject and provides a detailed look at the interplay between theory and practice, making it ideal for courses in quantitative analysis, instrumental analysis, and biochemistry, as well as courses focused solely on spectroscopy. It is also a valuable resource for practitioners working in laboratories who regularly perform spectroscopic analyses.
Spectroscopy: Principles and Instrumentation:Provides extensive coverage of principles, instrumentation, and applications of molecular spectroscopy Facilitates a modular approach to teaching and learning about chemical instrumentation Helps students visualize the effects that electromagnetic radiation in different regions of the spectrum has on matter Connects the fundamental theory of the effects of electromagnetic radiation on matter to the design and use of spectrophotometers Features numerous figures and diagrams to facilitate learning Includes several worked examples and companion exercises throughout each chapter so that readers can check their understanding Offers numerous problems at the end of each chapter to allow readers to apply what they have learned Includes case studies that illustrate how spectroscopy is used in practice, including analyzing works of art, studying the kinetics of enzymatic reactions, detecting explosives, and determining the DNA sequence of the human genome Complements Chromatography: Principles and Instrumentation
The book is divided into five chapters that cover the Fundamentals of Spectroscopy, UV-visible Spectroscopy, Fluorescence/Luminescence Spectroscopy, Infrared Spectroscopy, and Raman Spectroscopy. Each chapter details the theory upon which the specific techniques are based, provides ways for readers to visualize the molecular-level effects of electromagnetic radiation on matter, describes the design and components of spectrophotometers, discusses applications of each type of spectroscopy, and includes case studies that illustrate specific applications of spectroscopy.
Each chapter is divided into multiple sections using headings and subheadings, making it easy for readers to work through the book and to find specific information relevant to their interests. Numerous figures, exercises, worked examples, and end-of-chapter problems reinforce important concepts and facilitate learning.
Spectroscopy: Principles and Instrumentation is an excellent text that prepares undergraduate students and practitioners to operate in modern laboratories.
The possible applications of enzymes are enormous. Years of development have seen many enzymes brought onto the market, but they are still expensive to use. Therefore, their efficient application is a prerequisite for common usage. One of the main factors for this efficiency is the stability of the enzymes. The topics thus ranged from the extensive fundamental thermodynamic knowledge gathered in academic research to the practical applied knowledge built up in industry during the time that enzymes have been produced commercially.
The subject Stability and Stabilization of Enzymes was discussed from various points of view, as was reflected in the themes of the symposium sessions. In the session on Fundamentals of Enzyme Stabilisation the thermodynamic background of the phenomenon was highlighted. In yet another session, the recently developed analytical tools to measure enzyme stability and stabilisation were discussed. Further sessions comprised the physical, chemical and biological ways to obtain enzyme stabilisation and finally, the industrial practice of enzyme stabilisation was treated by representatives of the world's most important enzyme producers. The book will be of interest to researchers in universities and industry in the fields of biochemistry, enzymology and biotechnology.
Andreas Manz received the 2015 Inventor Award for "Lifetime Achievement" from the European Patent Office.
Petra S Dittrich will be presented with the Heinrich-Emanuel-Merck Award 2015 at EuroAnalysis2015 Conference.
Theory and Applications of Heat Transfer in Humans 2V Set offers a reference to the field of heating and cooling of tissue, and associated damage. The author—a noted expert in the field—presents, in this book, the fundamental physics and physiology related to the field, along with some of the recent applications, all in one place, in such a way as to enable and enrich both beginner and advanced readers. The book provides a basic framework that can be used to obtain ‘decent’ estimates of tissue temperatures for various applications involving tissue heating and/or cooling, and also presents ways to further develop more complex methods, if needed, to obtain more accurate results. The book is arranged in three sections: The first section, named ‘Physics’, presents fundamental mathematical frameworks that can be used as is or combined together forming more complex tools to determine tissue temperatures; the second section, named ‘Physiology’, presents ideas and data that provide the basis for the physiological assumptions needed to develop successful mathematical tools; and finally, the third section, named ‘Applications’, presents examples of how the marriage of the first two sections are used to solve problems of today and tomorrow.
This important text is the vital resource that:Offers a reference book in the field of heating and cooling of tissue, and associated damage. Provides a comprehensive theoretical and experimental basis with biomedical applications Shows how to develop and implement both, simple and complex mathematical models to predict tissue temperatures Includes simple examples and results so readers can use those results directly or adapt them for their applications
Designed for students, engineers, and other professionals, a comprehensive text to the field of heating and cooling of tissue that includes proven theories with applications. The author reveals how to develop simple and complex mathematical models, to predict tissue heating and/or cooling, and associated damage.
Emphasizing practical applications and real-world case studies, Materials Characterization Techniques presents the principles of widely used, advanced surface and structural characterization techniques for quality assurance, contamination control, and process improvement.
This useful volume:
Explores scientific processes to characterize materials using modern technologies Provides analysis of materials’ performance under specific use conditions Focuses on the interrelationships and interdependence between processing, structure, properties, and performance Details the sophisticated instruments involved in an interdisciplinary approach to understanding the wide range of mutually interacting processes, mechanisms, and materials Covers electron, X-ray-photoelectron, and UV spectroscopy; scanning-electron, atomic-force, transmission-electron, and laser-confocal-scanning-florescent microscopy, and gel electrophoresis chromatography Presents the fundamentals of vacuum, as well as X-ray diffraction principles
Explaining appropriate uses and related technical requirements for characterization techniques, the authors omit lengthy and often intimidating derivations and formulations. Instead, they emphasize useful basic principles and applications of modern technologies used to characterize engineering materials, helping readers grasp micro- and nanoscale properties. This text will serve as a valuable guide for scientists and engineers involved in characterization and also as a powerful introduction to the field for advanced undergraduate and graduate students.
This new edition has been thoroughly revised and updated and has been redesigned to give the book a more contemporary look. As with previous editions it contains numerous examples, references and a series of exercises of increasing difficulty to encourage student understanding. Updates include: Increased coverage of MALDI and ESI, more detailed description of time of flight spectrometers, new material on isotope ratio mass spectrometry, and an expanded range of applications.
Mass Spectrometry, Third Edition is an invaluable resource for all undergraduate and postgraduate students using this technique in departments of chemistry, biochemistry, medicine, pharmacology, agriculture, material science and food science. It is also of interest for researchers looking for an overview of the latest techniques and developments.
On the threshold of the new millennium when plasma emission and mass spectrometry are so important and popular, the editor considered it timely to produce a book which covers all present atomic detectors and techniques where FA has been or can be advantageously employed. The book has been conceived in three separate parts: Part I gives the fundamental, instrumentation and potential of FIA as a most versatile sample presentation/introduction system for atomic spectrometry. Part II provides a modern account of fundamentals, possibilities and applications offered by flow analysis to atomic spectrometry for on-line sample pretreatments, separations and preconcentrations. Part III deals with applications of FA-ASD combinations to analytical problem-solving in most varied fields and situations.
This monograph integrates the most popular aspects of FIA, its new developments for sample on-line treatments and on-line non-chromatographic and chromatographic separations (all typical 'flow analysis') in connection with all branches of analytical atomic spectrometry. Thus, academics, researchers and routine users of analytical atomic spectrometry will find this book invaluable.
Principle, experimental set ups, parameters and interpretation rules of several advanced IR-based techniques; application to biointerface characterisation through the presentation of recent examples, will be given in this book. It will describe how to characterise amino acids, protein or bacterial strain interactions with metal and oxide surfaces, by using infrared spectroscopy, in vacuum, in the air or in an aqueous medium. Results will highlight the performances and perspectives of the technique.Description of the principles, expermental setups and parameter interpretation, and the theory for several advanced IR-based techniques for interface characterisationContains examples which demonstrate the capacity, potential and limits of the IR techniquesHelps finding the most adequate mode of analysisContains examplesContains a glossary by techniques and by keywords
This book is an easy-to-use compendium of problems encountered when using various commonly used analytical techniques. Emphasis is on impurities, by-products, contaminants and other artifacts. A separate entry is provided for each artifact. For specific chemicals, this entry provides the common name, mass spectrum, gas chromatographic data, CAS name and registry number, synonyms and a narrative discussion. More than 1100 entries are included. Mass spectral data are indexed in a 6-peak index (molecular ion, base peak, second peak, third peak) and there are also formula, author and subject indexes. An extensive bibliography contains complete literature citations.
The book is designed to be used. It will not only allow experienced analysts to profit from the mistakes of others, but it will also be invaluable to other scientists who use analytical instruments in their work.
A discussion is then presented on carbon-13 NMR, detailing its pros and cons and showing how it can be used in conjunction with proton NMR via the pivotal 2-D techniques (HSQC and HMBC) to yield vital structural information. Some of the more specialist techniques available are then discussed, i.e. flow NMR, solvent suppression, Magic Angle Spinning, etc. Other important nuclei are then discussed and useful data supplied. This is followed by a discussion of the neglected use of NMR as a tool for quantification and new techniques for this explained. The book then considers the safety aspects of NMR spectroscopy, reviewing NMR software for spectral prediction and data handling and concludes with a set of worked Q&As.
Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing.
The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab.Provides readers with the keys to choosing, installing, and validating a mass spectrometry platformOffers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labsExplains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab
The aim of the book is twofold. Firstly, to reveal to the reader the combined use of different spectroscopic data, to facilitate an insight into the structure and conformational properties of any new piperidine derivative. Secondly, to establish a consistent link between conformation and reactivity for a variety of piperidine derivatives. Such a bridge is a key step for stereocontrol when dealing with the application of piperidine derivatives as synthetic intermediates. The book is conceived so that most of the information comes from visual inspection of the very abundant graphic material. An exhaustive subject index of more than 450 entries is also included.
New Advances And Development In Mass Spectrometry, Mass Spectrometry Applications, Mass Spectrometry In Pharmaceutical Industry, Spectroscopy, Mass Spectrometry Applications In Clinical Diagnostics, Capillary Electrophoresis, Tandem Mass Spectrometry, Environmental Analysis, Protein Mass Spectrometry, Ionization Techniques Mass Spectrometry, Forensic Analysis, Mass Spectrometry In Medicine, Imaging Mass Spectrometry, Analytical Chemistry, Molecular Mass Spectrometry
This is presented in a concise yet comprehensive manner and each section is prepared such that they can be read independently of each other, and all equations are presented using the most commonly used units. Greater emphasis has been placed on spectral understanding/interpretation. For completeness sake, a description of commonly used instrumentation is also presented. Finally, some complementary surface analytical techniques and associated concepts are reviewed for comparative purposes in stand-alone appendix sections.
This book summarizes the major advances and relevant applications of GC-MS techniques over the last 10 years, with chapters by leading authors in the field of environmental chemistry. The authors are drawn from academia, industry and government.
The book is organized in three main parts. Part I covers applications of basic GC-MS to solve environmental-related problems. Part II focuses on GC-MS-MS instrumentation for the analyses of a broad range of analysis in environmental samples (pesticides, persistent organic pollutants, endocrine disruptors, etc.). Part III covers the use of more advanced GC-MS techniques using low- and high-resolution mass spectrometry for many applications related to the environment, food and industry.Summarizes the major advances of GC-MS techniques in the last decadePresents relevant applications of GC-MS techniquesCovers academic, industrial and governmental sectors
This workbook:Features exercises to help develop the student's understanding of how structures are determined from spectra and to promote the student's own interpretation of different spectra. Covers a large range of spectroscopic data, including mass spectrometry, infrared and 1H and 13C nuclear magnetic resonance, typically used in the routine analysis of small-sized organic molecules. Presents in full-color, in a workbook-friendly format the spectra for interpretation with explanations and analyses on the facing page.