Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years.
The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist.
From the Persian Queen Atossa, whose Greek slave may have cut off her diseased breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease.
Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
What were the talents that allowed certain inventors and entrepreneurs to turn their visionary ideas into disruptive realities? What led to their creative leaps? Why did some succeed and others fail?
The Innovators is a masterly saga of collaborative genius destined to be the standard history of the digital revolution—and an indispensable guide to how innovation really happens. Isaacson begins the adventure with Ada Lovelace, Lord Byron’s daughter, who pioneered computer programming in the 1840s. He explores the fascinating personalities that created our current digital revolution, such as Vannevar Bush, Alan Turing, John von Neumann, J.C.R. Licklider, Doug Engelbart, Robert Noyce, Bill Gates, Steve Wozniak, Steve Jobs, Tim Berners-Lee, and Larry Page.
This is the story of how their minds worked and what made them so inventive. It’s also a narrative of how their ability to collaborate and master the art of teamwork made them even more creative. For an era that seeks to foster innovation, creativity, and teamwork, The Innovators is “a sweeping and surprisingly tenderhearted history of the digital age” (The New York Times).
Brad Stone enjoyed unprecedented access to current and former Amazon employees and Bezos family members, and his book is the first in-depth, fly-on-the-wall account of life at Amazon. The Everything Store is the book that the business world can't stop talking about, the revealing, definitive biography of the company that placed one of the first and largest bets on the Internet and forever changed the way we shop and read.
A New York Times Notable Book
A Washington Post and Seattle Times Best Book of the Year
From the Pulitzer Prize-winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle).
“Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.
“Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome.
“A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).
Acclaimed science writer James Gleick presents an eye-opening vision of how our relationship to information has transformed the very nature of human consciousness. A fascinating intellectual journey through the history of communication and information, from the language of Africa’s talking drums to the invention of written alphabets; from the electronic transmission of code to the origins of information theory, into the new information age and the current deluge of news, tweets, images, and blogs. Along the way, Gleick profiles key innovators, including Charles Babbage, Ada Lovelace, Samuel Morse, and Claude Shannon, and reveals how our understanding of information is transforming not only how we look at the world, but how we live.
A New York Times Notable Book
A Los Angeles Times and Cleveland Plain Dealer Best Book of the Year
Winner of the PEN/E. O. Wilson Literary Science Writing Award
For more than three decades, millions of consumers have trusted The Pill Book to provide official, FDA-approved information on more than 1,800 of the most commonly prescribed drugs in the United States with guidelines from leading pharmacists. Each drug is profiled in a concise, readable, easy-to-understand entry, making The Pill Book the perfect reference when you have questions about the medications your doctor prescribes. Inside you’ll discover
• generic and brand-name listings that can help you save money
• What each drug is for, and how it works
• usual dosages, and what to do if a dose is skipped
• side effects and possible adverse reactions, highlighted for quick reference
• interactions with other drugs and food
• overdose and addiction potential
• alcohol-free and sugar-free medications
• the most popular self-injected medications and their safe handling
• information for seniors, pregnant and breast-feeding women, children, and others with special needs
• cautions and warnings, and when to call your doctor
• 32 pages of actual-size color photographs of prescription pills*
No home should be without this book!
*Not all ereading devices will show the images in color and at the exact size.
The story that inspired the major motion picture produced by Brad Pitt, directed by Steve McQueen, and starring Chiwetel Ejiofor, Michael Fassbender, and Benedict Cumberbatch, Twelve Years a Slave is a harrowing, vividly detailed, and utterly unforgettable account of slavery. This beautifully designed ebook edition of Twelve Years a Slave features an introduction by Dolen Perkins-Valdez, the bestselling author of Wench.
Solomon Northup was an entrepreneur and dedicated family man, father to three young children, Elizabeth, Margaret, and Alonzo. What little free time he had after long days of manual and farm labor, he spent reading books and playing the violin. Though his father was born into slavery, Solomon was born and lived free.
In March 1841, two strangers approached Northup, offering him employment as a violinist in a town hundreds of miles away from his home in Saratoga Springs, New York. Solomon bid his wife farewell until his return. Only after he was drugged and bound, did he realize the strangers were kidnappers—that nefarious brand of criminals in the business of capturing runaway and free blacks for profit. Thus began Northup's life as a slave. Dehumanized, beaten, and worked mercilessly, Northup suffered all the more wondering what had become of his family. One owner was savagely cruel and Northup recalls he was "indebted to him for nothing, save undeserved abuse." Just as he felt the summer of his life fade and all hope nearly lost, he met a kind-hearted stranger who changed the course of his life. With its first-hand account of this country's Peculiar Institution, this is a book no one interested in American history can afford to miss.
First published in 1970, Bury My Heart at Wounded Knee generated shockwaves with its frank and heartbreaking depiction of the systematic annihilation of American Indian tribes across the western frontier. In this nonfiction account, Dee Brown focuses on the betrayals, battles, and massacres suffered by American Indians between 1860 and 1890. He tells of the many tribes and their renowned chiefs—from Geronimo to Red Cloud, Sitting Bull to Crazy Horse—who struggled to combat the destruction of their people and culture. Forcefully written and meticulously researched, Bury My Heart at Wounded Knee inspired a generation to take a second look at how the West was won. This ebook features an illustrated biography of Dee Brown including rare photos from the author’s personal collection.
Eric Schmidt is one of Silicon Valley’s great leaders, having taken Google from a small startup to one of the world’s most influential companies. Jared Cohen is the director of Google Ideas and a former adviser to secretaries of state Condoleezza Rice and Hillary Clinton. With their combined knowledge and experiences, the authors are uniquely positioned to take on some of the toughest questions about our future: Who will be more powerful in the future, the citizen or the state? Will technology make terrorism easier or harder to carry out? What is the relationship between privacy and security, and how much will we have to give up to be part of the new digital age?
In this groundbreaking book, Schmidt and Cohen combine observation and insight to outline the promise and peril awaiting us in the coming decades. At once pragmatic and inspirational, this is a forward-thinking account of where our world is headed and what this means for people, states and businesses.
With the confidence and clarity of visionaries, Schmidt and Cohen illustrate just how much we have to look forward to—and beware of—as the greatest information and technology revolution in human history continues to evolve. On individual, community and state levels, across every geographical and socioeconomic spectrum, they reveal the dramatic developments—good and bad—that will transform both our everyday lives and our understanding of self and society, as technology advances and our virtual identities become more and more fundamentally real.
As Schmidt and Cohen’s nuanced vision of the near future unfolds, an urban professional takes his driverless car to work, attends meetings via hologram and dispenses housekeeping robots by voice; a Congolese fisherwoman uses her smart phone to monitor market demand and coordinate sales (saving on costly refrigeration and preventing overfishing); the potential arises for “virtual statehood” and “Internet asylum” to liberate political dissidents and oppressed minorities, but also for tech-savvy autocracies (and perhaps democracies) to exploit their citizens’ mobile devices for ever more ubiquitous surveillance. Along the way, we meet a cadre of international figures—including Julian Assange—who explain their own visions of our technology-saturated future.
Inspiring, provocative and absorbing, The New Digital Age is a brilliant analysis of how our hyper-connected world will soon look, from two of our most prescient and informed public thinkers.
Two men, each handsome and unusually adept at his chosen work, embodied an element of the great dynamic that characterized America’s rush toward the twentieth century. The architect was Daniel Hudson Burnham, the fair’s brilliant director of works and the builder of many of the country’s most important structures, including the Flatiron Building in New York and Union Station in Washington, D.C. The murderer was Henry H. Holmes, a young doctor who, in a malign parody of the White City, built his “World’s Fair Hotel” just west of the fairgrounds—a torture palace complete with dissection table, gas chamber, and 3,000-degree crematorium.
Burnham overcame tremendous obstacles and tragedies as he organized the talents of Frederick Law Olmsted, Charles McKim, Louis Sullivan, and others to transform swampy Jackson Park into the White City, while Holmes used the attraction of the great fair and his own satanic charms to lure scores of young women to their deaths. What makes the story all the more chilling is that Holmes really lived, walking the grounds of that dream city by the lake.
The Devil in the White City draws the reader into a time of magic and majesty, made all the more appealing by a supporting cast of real-life characters, including Buffalo Bill, Theodore Dreiser, Susan B. Anthony, Thomas Edison, Archduke Francis Ferdinand, and others. Erik Larson’s gifts as a storyteller are magnificently displayed in this rich narrative of the master builder, the killer, and the great fair that obsessed them both.
To find out more about this book, go to http://www.DevilInTheWhiteCity.com.
The atomic bomb was not the only project to occupy government scientists in the 1940s. Antigravity technology, originally spearheaded by scientists in Nazi Germany, was another high priority, one that still may be in effect today. Now for the first time, a reporter with an unprecedented access to key sources in the intelligence and military communities reveals suppressed evidence that tells the story of a quest for a discovery that could prove as powerful as the A-bomb.
The Hunt for Zero Point explores the scientific speculation that a "zero point" of gravity exists in the universe and can be replicated here on Earth. The pressure to be the first nation to harness gravity is immense, as it means having the ability to build military planes of unlimited speed and range, along with the most deadly weaponry the world has ever seen. The ideal shape for a gravity-defying vehicle happens to be a perfect disk, making antigravity tests a possible explanation for the numerous UFO sightings of the past 50 years.
Chronicling the origins of antigravity research in the world's most advanced research facility, which was operated by the Third Reich during World War II, The Hunt for Zero Point traces U.S. involvement in the project, beginning with the recruitment of former Nazi scientists after the war. Drawn from interviews with those involved with the research and who visited labs in Europe and the United States, The Hunt for Zero Point journeys to the heart of the twentieth century's most puzzling unexplained phenomena.
From the Hardcover edition.
With The Structure of Scientific Revolutions, Kuhn challenged long-standing linear notions of scientific progress, arguing that transformative ideas don’t arise from the day-to-day, gradual process of experimentation and data accumulation but that the revolutions in science, those breakthrough moments that disrupt accepted thinking and offer unanticipated ideas, occur outside of “normal science,” as he called it. Though Kuhn was writing when physics ruled the sciences, his ideas on how scientific revolutions bring order to the anomalies that amass over time in research experiments are still instructive in our biotech age.
This new edition of Kuhn’s essential work in the history of science includes an insightful introduction by Ian Hacking, which clarifies terms popularized by Kuhn, including paradigm and incommensurability, and applies Kuhn’s ideas to the science of today. Usefully keyed to the separate sections of the book, Hacking’s introduction provides important background information as well as a contemporary context. Newly designed, with an expanded index, this edition will be eagerly welcomed by the next generation of readers seeking to understand the history of our perspectives on science.
The most up-to-date information about the more than 1,800 most commonly prescribed drugs in the United States:
• Generic and brand-name listings that can help you save money
• What the drug is for, and how it works
• Usual dosages, and what to do if a dose is skipped
• Side effects and possible adverse reactions, highlighted for quick reference
• Interactions with other drugs and food
• Overdose and addiction potential
• Alcohol-free and sugar-free medications
• The most popular self-injected medications and their safe handling
• Information for seniors, pregnant and breast-feeding women, children, and others with special needs
• Cautions and warnings, and when to call your doctor
• 32 pages of actual-size color photographs of prescription pills
From the Trade Paperback edition.
In this powerful, epic biography, David McCullough unfolds the adventurous life journey of John Adams, the brilliant, fiercely independent, often irascible, always honest Yankee patriot who spared nothing in his zeal for the American Revolution; who rose to become the second president of the United States and saved the country from blundering into an unnecessary war; who was learned beyond all but a few and regarded by some as “out of his senses”; and whose marriage to the wise and valiant Abigail Adams is one of the moving love stories in American history.
This is history on a grand scale—a book about politics and war and social issues, but also about human nature, love, religious faith, virtue, ambition, friendship, and betrayal, and the far-reaching consequences of noble ideas. Above all, John Adams is an enthralling, often surprising story of one of the most important and fascinating Americans who ever lived.
But the shot didn’t kill Garfield. The drama of what happened subsequently is a powerful story of a nation in turmoil. The unhinged assassin’s half-delivered strike shattered the fragile national mood of a country so recently fractured by civil war, and left the wounded president as the object of a bitter behind-the-scenes struggle for power—over his administration, over the nation’s future, and, hauntingly, over his medical care. A team of physicians administered shockingly archaic treatments, to disastrous effect. As his condition worsened, Garfield received help: Alexander Graham Bell, the inventor of the telephone, worked around the clock to invent a new device capable of finding the bullet.
Meticulously researched, epic in scope, and pulsating with an intimate human focus and high-velocity narrative drive, The Destiny of the Republic will stand alongside The Devil in the White City and The Professor and the Madman as a classic of narrative history.
From Steven Johnson, the dynamic thinker routinely compared to James Gleick, Dava Sobel, and Malcolm Gladwell, The Ghost Map is a riveting page-turner about a real-life historical hero, Dr. John Snow. It's the summer of 1854, and London is just emerging as one of the first modern cities in the world. But lacking the infrastructure -- garbage removal, clean water, sewers -- necessary to support its rapidly expanding population, the city has become the perfect breeding ground for a terrifying disease no one knows how to cure. As the cholera outbreak takes hold, a physician and a local curate are spurred to action-and ultimately solve the most pressing medical riddle of their time.
In a triumph of multidisciplinary thinking, Johnson illuminates the intertwined histories and interconnectedness of the spread of disease, contagion theory, the rise of cities, and the nature of scientific inquiry, offering both a riveting history and a powerful explanation of how it has shaped the world we live in.
In the past decade alone, Google introduced us to driverless cars, Apple debuted a personal assistant that we keep in our pockets, and an Internet of Things connected the smaller tasks of everyday life to the farthest reaches of the internet. There is little doubt that robots are now an integral part of society, and cheap sensors and powerful computers will ensure that, in the coming years, these robots will soon act on their own. This new era offers the promise of immense computing power, but it also reframes a question first raised more than half a century ago, at the birth of the intelligent machine: Will we control these systems, or will they control us?
In Machines of Loving Grace, New York Times reporter John Markoff, the first reporter to cover the World Wide Web, offers a sweeping history of the complicated and evolving relationship between humans and computers. Over the recent years, the pace of technological change has accelerated dramatically, reintroducing this difficult ethical quandary with newer and far weightier consequences. As Markoff chronicles the history of automation, from the birth of the artificial intelligence and intelligence augmentation communities in the 1950s, to the modern day brain trusts at Google and Apple in Silicon Valley, and on to the expanding tech corridor between Boston and New York, he traces the different ways developers have addressed this fundamental problem and urges them to carefully consider the consequences of their work.
We are on the verge of a technological revolution, Markoff argues, and robots will profoundly transform the way our lives are organized. Developers must now draw a bright line between what is human and what is machine, or risk upsetting the delicate balance between them.
This book of clinical pharmacology covers the science of drugs or pharmaceutical including their origin, composition, pharmacokinetics, mechanism of action, therapeutic use, side effects and toxicology with specific description of drugs followed by short headings makes it easy to understand and point-wise explanation of information. This clinical pharmacology book will be helpful for the medical students and practicing doctors.
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Witches, Midwives, and Nurses, first published by the Feminist Press in 1973, is an essential book about the corruption of the medical establishment and its historic roots in witch hunters. In this new edition, Barbara Ehrenreich and Deirdre English have written an entirely new chapter that delves into the current fascination with and controversies about witches, exposing our fears and fantasies. They build on their classic exposé on the demonization of women healers and the political and economic monopolization of medicine. This quick history brings us up-to-date, exploring today's changing attitudes toward childbirth, alternative medicine, and modern-day witches.
This is the little-known story of how a newly independent nation was challenged by four Muslim powers and what happened when America’s third president decided to stand up to intimidation.
When Thomas Jefferson became president in 1801, America faced a crisis. The new nation was deeply in debt and needed its economy to grow quickly, but its merchant ships were under attack. Pirates from North Africa’s Barbary coast routinely captured American sailors and held them as slaves, demanding ransom and tribute payments far beyond what the new country could afford.
Over the previous fifteen years, as a diplomat and then as secretary of state, Jefferson had tried to work with the Barbary states (Tripoli, Tunis, Algiers, and Morocco). Unfortunately, he found it impossible to negotiate with people who believed their religion justified the plunder and enslavement of non-Muslims. These rogue states would show no mercy—at least not while easy money could be made by extorting the Western powers. So President Jefferson decided to move beyond diplomacy. He sent the U.S. Navy’s new warships and a detachment of Marines to blockade Tripoli—launching the Barbary Wars and beginning America’s journey toward future superpower status.
As they did in their previous bestseller, George Washington’s Secret Six, Kilmeade and Yaeger have transformed a nearly forgotten slice of history into a dramatic story that will keep you turning the pages to find out what happens next. Among the many suspenseful episodes:
·Lieutenant Andrew Sterett’s ferocious cannon battle on the high seas against the treacherous pirate ship Tripoli.
·Lieutenant Stephen Decatur’s daring night raid of an enemy harbor, with the aim of destroying an American ship that had fallen into the pirates’ hands.
·General William Eaton’s unprecedented five-hundred-mile land march from Egypt to the port of Derne, where the Marines launched a surprise attack and an American flag was raised in victory on foreign soil for the first time.
Few today remember these men and other heroes who inspired the Marine Corps hymn: “From the Halls of Montezuma to the Shores of Tripoli, we fight our country’s battles in the air, on land and sea.” Thomas Jefferson and the Tripoli Pirates recaptures this forgotten war that changed American history with a real-life drama of intrigue, bravery, and battle on the high seas.
In Killer Fat, Natalie Boero examines how and why obesity emerged as a major public health concern and national obsession in recent years. Using primary sources and in-depth interviews, Boero enters the world of bariatric surgeries, Weight Watchers, and Overeaters Anonymous to show how common expectations of what bodies are supposed to look like help to determine what sorts of interventions and policies are considered urgent in containing this new kind of disease.
Boero argues that obesity, like the traditional epidemics of biological contagion and mass death, now incites panic, a doomsday scenario that must be confronted in a struggle for social stability. The “war” on obesity, she concludes, is a form of social control. Killer Fat ultimately offers an alternate framing of the nation’s obesity problem based on the insights of the “Health at Every Size” movement.
Blending cultural studies and the history of communication technology, Sterne follows modern sound technologies back through a historical labyrinth. Along the way, he encounters capitalists and inventors, musicians and philosophers, embalmers and grave robbers, doctors and patients, deaf children and their teachers, professionals and hobbyists, folklorists and tribal singers. The Audible Past tracks the connections between the history of sound and the defining features of modernity: from developments in medicine, physics, and philosophy to the tumultuous shifts of industrial capitalism, colonialism, urbanization, modern technology, and the rise of a new middle class.
A provocative history of sound, The Audible Past challenges theoretical commonplaces such as the philosophical privilege of the speaking subject, the visual bias in theories of modernity, and static descriptions of nature. It will interest those in cultural studies, media and communication studies, the new musicology, and the history of technology.
DMSO is a natural chemical compound derived from trees as a by-product from paper manufacturing. DMSO has been called a new medical principle and a true wonder drug. It has proven effective, either by itself or in combination with other products in the treatment of nearly every ailment known.
There has been much controversy about DMSO over the last 50 years. It is one of the most studied medical products ever. Thousands of scientific articles have been written about DMSO. When used properly it is one of the safest products know. It is also very cheap to produce.
This book provides the documentation needed to show that DMSO is probably the most important product ever for the relief of human suffering.
******Archie is quite clearly a leading authorithy on DMSO. He has extensive knowledge and experience regarding the clinical benefits of DMSO treatment. For decades, Archie has studied and worked with DMSO. He understands the safety, utility and efficaciousness of DMSO. I highly recommend this book for anyone interested in health, especially for those who want to learn more about non toxic medical therapies. For individuals with certain health ailments, DMSO could prove quite benefical. -Daniel Junck, MD
When a deadly diphtheria epidemic swept through Nome, Alaska, in 1925, the local doctor knew that without a fresh batch of antitoxin, his patients would die. The lifesaving serum was a thousand miles away, the port was icebound, and planes couldn't fly in blizzard conditions—only the dogs could make it. The heroic dash of dog teams across the Alaskan wilderness to Nome inspired the annual Iditarod Trail Sled Dog Race and immortalized Balto, the lead dog of the last team whose bronze statue still stands in New York City's Central Park. This is the greatest dog story, never fully told until now.
Often hailed the “most important company in the world,” Intel remains, more than four decades after its inception, a defining company of the global digital economy. The legendary inventors of the microprocessor-the single most important product in the modern world-Intel today builds the tiny “engines” that power almost every intelligent electronic device on the planet.
But the true story of Intel is the human story of the trio of geniuses behind it. Michael S. Malone reveals how each brought different things to Intel, and at different times. Noyce, the most respected high tech figure of his generation, brought credibility (and money) to the company’s founding; Moore made Intel the world’s technological leader; and Grove, has relentlessly driven the company to ever-higher levels of success and competitiveness. Without any one of these figures, Intel would never have achieved its historic success; with them, Intel made possible the personal computer, Internet, telecommunications, and the personal electronics revolutions.
The Intel Trinity is not just the story of Intel’s legendary past; it also offers an analysis of the formidable challenges that lie ahead as the company struggles to maintain its dominance, its culture, and its legacy.
With eight pages of black-and-white photos.
In sharply argued, fast-moving chapters, Cory Doctorow’s Information Doesn’t Want to Be Free takes on the state of copyright and creative success in the digital age. Can small artists still thrive in the Internet era? Can giant record labels avoid alienating their audiences? This is a book about the pitfalls and the opportunities that creative industries (and individuals) are confronting today — about how the old models have failed or found new footing, and about what might soon replace them. An essential read for anyone with a stake in the future of the arts, Information Doesn’t Want to Be Free offers a vivid guide to the ways creativity and the Internet interact today, and to what might be coming next. This book is DRM-free.
Kratom and Other Mitragynines: The Chemistry and Pharmacology of Opioids from a Non-Opium Sourcepresents an introduction to the chemical and biological properties of alkaloids isolated from M. speciosa as well as their synthetic analogs. The book covers various topics including phytochemistry, medicinal chemistry, and pharmacology. Current research, analgesic effects, and addiction potential are also discussed. As the first extensive text on the basic science and clinical use of Kratom, the book provides readers with a concise yet comprehensive introduction to nature’s "other opioid."
Author Sebastian Enfield had it all. A loving family, an up-and-coming career at a Fortune 500 company, good friends and an active social life. He was living the proverbial American dream. Until, that is, his life was sidetracked when he became addicted to painkillers. It all started with far-too-easy online purchases of narcotic pills, and eventually Sebastian “graduated” to heroin. As with most addicts, as his opiate habit developed his life began to unravel. Family, friends and career became less and less important. Maintaining his expensive addiction became the most important priority each day. But when a winter blizzard came one December and “his guy” stopped returning his phone calls, Sebastian knew another kind of storm was heading his way. Withdrawal. He suffered in bed for a few days before his dealer finally returned his calls and delivered the goods. But this was the final turning point. After all he had gone through, Sebastian knew things couldn’t continue like this. So he made arrangements to visit a Suboxone-prescribing doctor, and very shortly thereafter, he was finally on the long road to recovery.
But while being treated with Suboxone, Sebastian had some anxieties and a lot of questions. “How long should I really be on this stuff? Should I try to taper off or not? And if so, how do you do it so as to minimize any discomfort? What other things should I be doing to aid in my recovery?” He looked to the Internet for answers, but what he found was a lot of contradictory information, posts from people claiming that “this stuff is even worse than what I was on before!”, and even disagreement among doctors and other health professionals with regard to Suboxone treatment protocols. Sebastian suspected that if he found all this confusing, there were probably many others in the same boat.
And so, he set out to investigate all of this, and to write a book that explained his findings in clear and simple terms. Sebastian spoke with various doctors, Suboxone patients and therapists, and synthesized their views and opinions, along with his own experiences, into a book of tips and suggestions that would help doctors and patients best approach buprenorphine treatment.
Sebastian begins with his own compelling story, where he details the life journey that ultimately led to drug addiction. He then presents several suggestions and tips that cover a wide range of questions he knew Suboxone patients had. The book covers a variety of topics, such as how to best select a doctor, how to approach counseling (and whether you really need counseling), how to taper off the medication with minimal discomfort (and whether you even should taper off the medication), resources that may help with paying for treatment, and a variety of “lifestyle hacks” Sebastian found to be useful while being treated. Sebastian lays all of this out clearly, and provides a positive and motivating read that will help patients understand that treatment with buprenorphine need not be a scary and uncertain thing. On the contrary, it can be a constructive part of recovery from opiate addiction. As he put it, “This is the book I wish I had when I began buprenorphine treatment.”
S.C. Gwynne’s Empire of the Summer Moon spans two astonishing stories. The first traces the rise and fall of the Comanches, the most powerful Indian tribe in American history. The second entails one of the most remarkable narratives ever to come out of the Old West: the epic saga of the pioneer woman Cynthia Ann Parker and her mixed-blood son Quanah, who became the last and greatest chief of the Comanches.
Although readers may be more familiar with the tribal names Apache and Sioux, it was in fact the legendary fighting ability of the Comanches that determined just how and when the American West opened up. Comanche boys became adept bareback riders by age six; full Comanche braves were considered the best horsemen who ever rode. They were so masterful at war and so skillful with their arrows and lances that they stopped the northern drive of colonial Spain from Mexico and halted the French expansion westward from Louisiana. White settlers arriving in Texas from the eastern United States were surprised to find the frontier being rolled backward by Comanches incensed by the invasion of their tribal lands. So effective were the Comanches that they forced the creation of the Texas Rangers and account for the advent of the new weapon specifically designed to fight them: the six-gun.
The war with the Comanches lasted four decades, in effect holding up the development of the new American nation. Gwynne’s exhilarating account delivers a sweeping narrative that encompasses Spanish colonialism, the Civil War, the destruction of the buffalo herds, and the arrival of the railroads—a historical feast for anyone interested in how the United States came into being.
Against this backdrop Gwynne presents the compelling drama of Cynthia Ann Parker, a lovely nine-year-old girl with cornflower-blue eyes who was kidnapped by Comanches from the far Texas frontier in 1836. She grew to love her captors and became infamous as the "White Squaw" who refused to return until her tragic capture by Texas Rangers in 1860. More famous still was her son Quanah, a warrior who was never defeated and whose guerrilla wars in the Texas Panhandle made him a legend.
S. C. Gwynne’s account of these events is meticulously researched, intellectually provocative, and, above all, thrillingly told. Empire of the Summer Moon announces him as a major new writer of American history.
In the late nineteenth century, people were obsessed by one of the last unmapped areas of the globe: the North Pole. No one knew what existed beyond the fortress of ice rimming the northern oceans, although theories abounded. The foremost cartographer in the world, a German named August Petermann, believed that warm currents sustained a verdant island at the top of the world. National glory would fall to whoever could plant his flag upon its shores.
James Gordon Bennett, the eccentric and stupendously wealthy owner of The New York Herald, had recently captured the world's attention by dispatching Stanley to Africa to find Dr. Livingstone. Now he was keen to re-create that sensation on an even more epic scale. So he funded an official U.S. naval expedition to reach the Pole, choosing as its captain a young officer named George Washington De Long, who had gained fame for a rescue operation off the coast of Greenland. De Long led a team of 32 men deep into uncharted Arctic waters, carrying the aspirations of a young country burning to become a world power. On July 8, 1879, the USS Jeannette set sail from San Francisco to cheering crowds in the grip of "Arctic Fever."
The ship sailed into uncharted seas, but soon was trapped in pack ice. Two years into the harrowing voyage, the hull was breached. Amid the rush of water and the shrieks of breaking wooden boards, the crew abandoned the ship. Less than an hour later, the Jeannette sank to the bottom,and the men found themselves marooned a thousand miles north of Siberia with only the barest supplies. Thus began their long march across the endless ice—a frozen hell in the most lonesome corner of the world. Facing everything from snow blindness and polar bears to ferocious storms and frosty labyrinths, the expedition battled madness and starvation as they desperately strove for survival.
With twists and turns worthy of a thriller, In The Kingdom of Ice is a spellbinding tale of heroism and determination in the most unforgiving territory on Earth.
Ebook edition includes over a dozen extra images
How did the popularity of underwear in the twelfth century lead to the invention of the printing press? How did the waterwheel evolve into the computer? How did the arrival of the cannon lead eventually to the development of movies?
In this highly acclaimed and bestselling book, James Burke brilliantly examines the ideas, inventions, and coincidences that have culminated in the major technological advances of today. With dazzling insight, he untangles the pattern of interconnecting events: the accidents of time, circumstance, and place that gave rise to the major inventions of the world.
Says Burke, "My purpose is to acquaint the reader with some of the forces that have caused change in the past, looking in particular at eight innovations—the computer, the production line, telecommunications, the airplane, the atomic bomb, plastics, the guided rocket, and television—which may be most influential in structuring our own futures....Each one of these is part of a family of similar devices, and is the result of a sequence of closely connected events extending from the ancient world until the present day. Each has enormous potential for humankind's benefit—or destruction."
Based on a popular TV documentary series, Connections is a fascinating scientific detective story of the inventions that changed history—and the surprising links that connect them.
On the evening of April 13, 1970, the three astronauts aboard Apollo 13 were just hours from the third lunar landing in history. But as they soared through space, two hundred thousand miles from Earth, an explosion badly damaged their spacecraft. With compromised engines and failing life-support systems, the crew was in incomparably grave danger. Faced with below-freezing temperatures, a seriously ill crewmember, and a dwindling water supply, a safe return seemed unlikely.
Thirteen is the shocking and miraculous true story of how the astronauts and ground crew guided Apollo 13 back to Earth. Expanding on dispatches written for the New Yorker, Henry S. F. Cooper Jr. brings readers unparalleled detail on the moment-by-moment developments of one of NASA’s most dramatic missions.
Born into a life of bondage, Frederick Douglass secretly taught himself to read and write. It was a crime punishable by death, but it resulted in one of the most eloquent indictments of slavery ever recorded. His gripping narrative takes us into the fields, cabins, and manors of pre-Civil War plantations in the South and reveals the daily terrors he suffered as a slave.
Written more than a century and a half ago by an African-American who went on to become a famous orator, U.S. minister to Haiti, and leader of his people, this timeless classic still speaks directly to our age. It is a record of savagery and inhumanity that goes far to explain why America still suffers from the great injustices of the past.
With an Introduction by Peter J. Gomes
and an Afterword by Gregory Stephens
If all measures of human advancement in the last hundred centuries were plotted on a graph, they would show an almost perfectly flat line—until the eighteenth century, when the Industrial Revolution would cause the line to shoot straight up, beginning an almost uninterrupted march of progress.
In The Most Powerful Idea in the World, William Rosen tells the story of the men responsible for the Industrial Revolution and the machine that drove it—the steam engine. In the process he tackles the question that has obsessed historians ever since: What made eighteenth-century Britain such fertile soil for inventors? Rosen’s answer focuses on a simple notion that had become enshrined in British law the century before: that people had the right to own and profit from their ideas.
The result was a period of frantic innovation revolving particularly around the promise of steam power. Rosen traces the steam engine’s history from its early days as a clumsy but sturdy machine, to its coming-of-age driving the wheels of mills and factories, to its maturity as a transporter for people and freight by rail and by sea. Along the way we enter the minds of such inventors as Thomas Newcomen and James Watt, scientists including Robert Boyle and Joseph Black, and philosophers John Locke and Adam Smith—all of whose insights, tenacity, and ideas transformed first a nation and then the world.
William Rosen is a masterly storyteller with a keen eye for the “aha!” moments of invention and a gift for clear and entertaining explanations of science. The Most Powerful Idea in the World will appeal to readers fascinated with history, science, and the hows and whys of innovation itself.
From the Hardcover edition.
From Russia to Bengal to Palm Beach, Randall Packard’s far-ranging narrative traces the natural and social forces that help malaria spread and make it deadly. He finds that war, land development, crumbling health systems, and globalization—coupled with climate change and changes in the distribution and flow of water—create conditions in which malaria's carrier mosquitoes thrive. The combination of these forces, Packard contends, makes the tropical regions today a perfect home for the disease.
Authoritative, fascinating, and eye-opening, this short history of malaria concludes with policy recommendations for improving control strategies and saving lives.
In Thunderstruck, Erik Larson tells the interwoven stories of two men—Hawley Crippen, a very unlikely murderer, and Guglielmo Marconi, the obsessive creator of a seemingly supernatural means of communication—whose lives intersect during one of the greatest criminal chases of all time.
Set in Edwardian London and on the stormy coasts of Cornwall, Cape Cod, and Nova Scotia, Thunderstruck evokes the dynamism of those years when great shipping companies competed to build the biggest, fastest ocean liners; scientific advances dazzled the public with visions of a world transformed; and the rich outdid one another with ostentatious displays of wealth. Against this background, Marconi races against incredible odds and relentless skepticism to perfect his invention: the wireless, a prime catalyst for the emergence of the world we know today. Meanwhile, Crippen, “the kindest of men,” nearly commits the perfect murder.
With his unparalleled narrative skills, Erik Larson guides us through a relentlessly suspenseful chase over the waters of the North Atlantic. Along the way, he tells of a sad and tragic love affair that was described on the front pages of newspapers around the world, a chief inspector who found himself strangely sympathetic to the killer and his lover, and a driven and compelling inventor who transformed the way we communicate.
Linking prehistoric archaeological remains with the development of language, David Anthony identifies the prehistoric peoples of central Eurasia's steppe grasslands as the original speakers of Proto-Indo-European, and shows how their innovative use of the ox wagon, horseback riding, and the warrior's chariot turned the Eurasian steppes into a thriving transcontinental corridor of communication, commerce, and cultural exchange. He explains how they spread their traditions and gave rise to important advances in copper mining, warfare, and patron-client political institutions, thereby ushering in an era of vibrant social change. Anthony also describes his fascinating discovery of how the wear from bits on ancient horse teeth reveals the origins of horseback riding.
The Horse, the Wheel, and Language solves a puzzle that has vexed scholars for two centuries--the source of the Indo-European languages and English--and recovers a magnificent and influential civilization from the past.
The plague first sailed into San Francisco on the steamer Australia, on the day after New Year’s in 1900. Though the ship passed inspection, some of her stowaways—infected rats—escaped detection and made their way into the city’s sewer system. Two months later, the first human case of bubonic plague surfaced in Chinatown.
Initially in charge of the government’s response was Quarantine Officer Dr. Joseph Kinyoun. An intellectually astute but autocratic scientist, Kinyoun lacked the diplomatic skill to manage the public health crisis successfully. He correctly diagnosed the plague, but because of his quarantine efforts, he was branded an alarmist and a racist, and was forced from his post. When a second epidemic erupted five years later, the more self-possessed and charming Dr. Rupert Blue was placed in command. He won the trust of San Franciscans by shifting the government’s attack on the plague from the cool remove of the laboratory onto the streets, among the people it affected. Blue preached sanitation to contain the disease, but it was only when he focused his attack on the newly discovered source of the plague, infected rats and their fleas, that he finally eradicated it—truly one of the great, if little known, triumphs in American public health history.
With stunning narrative immediacy fortified by rich research, Marilyn Chase transports us to the city during the late Victorian age—a roiling melting pot of races and cultures that, nearly destroyed by an earthquake, was reborn, thanks in no small part to Rupert Blue and his motley band of pied pipers.
From the Hardcover edition.
Relive the heartwarming true story of the discovery of insulin as it's never been told before. Written with authentic detail and suspense, and featuring walk-ons by William Howard Taft, Woodrow Wilson, and Eli Lilly himself, among many others.
Award-winning medical historian Victoria A. Harden approaches the AIDS virus from philosophical and intellectual perspectives in the history of medical science, discussing the process of scientific discovery, scientific evidence, and how laboratories found the cause of AIDS and developed therapeutic interventions. Similarly, her book places AIDS as the first infectious disease to be recognized simultaneously worldwide as a single phenomenon.
After years of believing that vaccines and antibiotics would keep deadly epidemics away, researchers, doctors, patients, and the public were forced to abandon the arrogant assumption that they had conquered infectious diseases. By presenting an accessible discussion of the history of HIV/AIDS and analyzing how aspects of society advanced or hindered the response to the disease, AIDS at 30 illustrates for both medical professionals and general readers how medicine identifies and evaluates new infectious diseases quickly and what political and cultural factors limit the medical community’s response.
In 1876, America was eager to celebrate its centenary, but questioned what might lie ahead. The American Republic had grown to four times its original population, and was in the midst of enormous changes. Industrialization was booming, and new energy sources were being used for fuel and power. People were suddenly less bound to agriculture, and there were revolutions in transportation and communication. It was a time of Indian wars, the first stirrings of the labor movement, and the burgeoning struggle form women’s and other civil rights. Historian Dee Brown takes the measure of America in a rare moment of reflection on the nation’s past, present, and future. The Year of the Century was one of Brown’s favorites among his works. In page-turning prose, he tells of a tumultuous era and of a young nation taking stock. This ebook features an illustrated biography of Dee Brown including rare photos from the author’s personal collection.
Every card includes:Generic and common name Class Dosage Forms Approved Dose and Indications Off-Label Use Contraindications Adverse Reactions Drug Interactions Monitoring Parameters Medication Safety Issues and Black Box Warnings Clinical pearls that help guide patient care Strong focus on patient safety
This edition is enhanced by 11 new cards, key adult and pediatric immunization vaccines, and MP3 audio download with detailed discussion of each drug.
It links the technological enthusiasms of the present day with the ancient and enduring Christian expectation of recovering humankind's lost divinity. Covering a period of a thousand years, Noble traces the evolution of the Western idea of technological development from the ninth century, when the useful arts became connected to the concept of redemption, up to the twentieth, when humans began to exercise God-like knowledge and powers.
Noble describes how technological advance accelerated at the very point when it was invested with spiritual significance. By examining the imaginings of monks, explorers, magi, scientists, Freemasons, and engineers, this historical account brings to light an other-worldly inspiration behind the apparently worldly endeavors by which we habitually define Western civilization. Thus we see that Isaac Newton devoted his lifetime to the interpretation of prophecy. Joseph Priestley was the discoverer of oxygen and a founder of Unitarianism. Freemasons were early advocates of industrialization and the fathers of the engineering profession. Wernher von Braun saw spaceflight as a millenarian new beginning for humankind.
The narrative moves into our own time through the technological enterprises of the last half of the twentieth century: nuclear weapons, manned space exploration, Artificial Intelligence, and genetic engineering. Here the book suggests that the convergence of technology and religion has outlived its usefulness, that though it once contributed to human well-being, it has now become a threat to our survival. Viewed at the dawn of the new millennium, the technological means upon which we have come to rely for the preservation and enlargement of our lives betray an increasing impatience with life and a disdainful disregard for mortal needs. David F. Noble thus contends that we must collectively strive to disabuse ourselves of the inherited religion of technology and begin rigorously to re-examine our enchantment with unregulated technological advance.
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BUT THE FIRST TO DANCE ON IT.
HE WAS THE ROCKETMAN.
For Pete Conrad, it was all about the ride. Whether he was hot-dogging at Mach 2, test-flying every supersonic jet the Navy developed (and some they shouldn’t have), orbiting the Earth at almost 20,000 mph, or redlining his Corvette, he loved pushing the envelope.
Pete wasn’t the squeaky-clean astronaut poster boy. The guy every NASA pilot wanted to happy-hour with after work—and would kill to fly with—Pete had a natural outspokenness that got him washed out of the Mercury program. But the “Comeback Kid” came roaring back—flying two Gemini missions, walking on the Moon as commander of Apollo 12, commanding the first Skylab, and logging more time in space than all the original astronauts combined.
This is a surprisingly candid insider’s view of the greatest ride in history: America’s glorious race to the stars, as seen through the eyes of a real space cowboy.
In 1803 President Thomas Jefferson selected his personal secretary, Captain Meriwether Lewis, to lead a voyage up the Missouri River to the Rockies, over the mountains, down the Columbia River to the Pacific Ocean, and back. Lewis and his partner, Captain William Clark, made the first map of the trans-Mississippi West, provided invaluable scientific data on the flora and fauna of the Louisiana Purchase territory, and established the American claim to Oregon, Washington, and Idaho.
Ambrose has pieced together previously unknown information about weather, terrain, and medical knowledge at the time to provide a vivid backdrop for the expedition. Lewis is supported by a rich variety of colorful characters, first of all Jefferson himself, whose interest in exploring and acquiring the American West went back thirty years. Next comes Clark, a rugged frontiersman whose love for Lewis matched Jefferson’s. There are numerous Indian chiefs, and Sacagawea, the Indian girl who accompanied the expedition, along with the French-Indian hunter Drouillard, the great naturalists of Philadelphia, the French and Spanish fur traders of St. Louis, John Quincy Adams, and many more leading political, scientific, and military figures of the turn of the century.
High adventure, high politics, suspense, drama, and diplomacy combine with high romance and personal tragedy to make this outstanding work of scholarship as readable as a novel.
Why did NASA managers, who not only had all the information prior to the launch but also were warned against it, decide to proceed? In retelling how the decision unfolded through the eyes of the managers and the engineers, Vaughan uncovers an incremental descent into poor judgment, supported by a culture of high-risk technology. She reveals how and why NASA insiders, when repeatedly faced with evidence that something was wrong, normalized the deviance so that it became acceptable to them. In a new preface, Vaughan reveals the ramifications for this book and for her when a similar decision-making process brought down NASA's Space Shuttle Columbia in 2003.
When Freud and Halsted began their experiments with cocaine in the 1880s, neither they, nor their colleagues, had any idea of the drug's potential to dominate and endanger their lives. An Anatomy of Addiction tells the tragic and heroic story of each man, accidentally struck down in his prime by an insidious malady: tragic because of the time, relationships, and health cocaine forced each to squander; heroic in the intense battle each man waged to overcome his affliction. Markel writes of the physical and emotional damage caused by the then-heralded wonder drug, and how each man ultimately changed the world in spite of it—or because of it. One became the father of psychoanalysis; the other, of modern surgery. Here is the full story, long overlooked, told in its rich historical context.