Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years.
The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist.
From the Persian Queen Atossa, whose Greek slave may have cut off her diseased breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease.
Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
A New York Times Notable Book
A Washington Post and Seattle Times Best Book of the Year
From the Pulitzer Prize-winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle).
“Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.
“Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome.
“A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).
The book explains in clear terms the theory that underpins magnetic resonance so that the capabilities and operation of MRI systems can be fully appreciated and maximised. This fourth edition captures recent advances, and coverage includes: parallel imaging techniques and new sequences such as balanced gradient echo.
Building on the success of the first three editions, the fourth edition has been fully revised and updated. The book now comes with a companion website at www.wiley.com/go/mriinpractice which hosts animated versions of a selection of illustrations in the book that are used on the MRI in Practice Course. These animations and accompanying text are aimed at helping the reader’s comprehension of some of the more difficult concepts. The website also hosts over 200 interactive self-assessment exercises to help the reader test their understanding.
MRI in Practice features:Full color illustrations Logical presentation of the theory and applications of MRI A new page design A companion website at www.wiley.com/go/mriinpractice featuring interactive multiple choice questions, short answer questions PLUS animations of more complex concepts from the book
For more information on the MRI in Practice Course and other learning resources by Westbrook and Talbot, please visit www.mrieducation.com
Witches, Midwives, and Nurses, first published by the Feminist Press in 1973, is an essential book about the corruption of the medical establishment and its historic roots in witch hunters. In this new edition, Barbara Ehrenreich and Deirdre English have written an entirely new chapter that delves into the current fascination with and controversies about witches, exposing our fears and fantasies. They build on their classic exposé on the demonization of women healers and the political and economic monopolization of medicine. This quick history brings us up-to-date, exploring today's changing attitudes toward childbirth, alternative medicine, and modern-day witches.
Imaging Informatics Professionals (IIPs) have come to play an indispensable role in modern medicine, and the scope of this profession has grown far beyond the boundaries of the PACS. A successful IIP must not only understand the PACS itself, but also have knowledge of clinical workflow, a base in several medical specialties, and a solid IT capability regarding software interactions and networking. With the introduction of a certification test for the IIP position, a single source was needed to explain the fundamentals of imaging informatics and to demonstrate how those fundamentals are applied in everyday practice. Practical Imaging Informatics describes the foundations of information technology and clinical image management, details typical daily operations, and discusses rarer complications and issues.
In Killer Fat, Natalie Boero examines how and why obesity emerged as a major public health concern and national obsession in recent years. Using primary sources and in-depth interviews, Boero enters the world of bariatric surgeries, Weight Watchers, and Overeaters Anonymous to show how common expectations of what bodies are supposed to look like help to determine what sorts of interventions and policies are considered urgent in containing this new kind of disease.
Boero argues that obesity, like the traditional epidemics of biological contagion and mass death, now incites panic, a doomsday scenario that must be confronted in a struggle for social stability. The “war” on obesity, she concludes, is a form of social control. Killer Fat ultimately offers an alternate framing of the nation’s obesity problem based on the insights of the “Health at Every Size” movement.
When a deadly diphtheria epidemic swept through Nome, Alaska, in 1925, the local doctor knew that without a fresh batch of antitoxin, his patients would die. The lifesaving serum was a thousand miles away, the port was icebound, and planes couldn't fly in blizzard conditions—only the dogs could make it. The heroic dash of dog teams across the Alaskan wilderness to Nome inspired the annual Iditarod Trail Sled Dog Race and immortalized Balto, the lead dog of the last team whose bronze statue still stands in New York City's Central Park. This is the greatest dog story, never fully told until now.
Easily review and visualize important facts with more than 1,000 high-quality pictures, charts, lists, boxes, tables, differential diagnoses and suggested readings.
Get all you need for daily reference with a concise, yet comprehensive format.Interpret the findings generated from each high-tech imaging modality used to study the brain, spine, head, and neck, including diffusion weighted imaging, perfusion weighted imaging, CT angiography, MR angiography, and MR spectroscopy.
Carry and consult this resource easily with its new, more compact book size.
Handy, pocket size offers easy, immediate access right at the console.
600 images provide multiple views and superb anatomic detail.
Suggested technical parameters are provided in convenient tables for quick reference with space to write in site-specific protocols or equipment variations.
From Russia to Bengal to Palm Beach, Randall Packard’s far-ranging narrative traces the natural and social forces that help malaria spread and make it deadly. He finds that war, land development, crumbling health systems, and globalization—coupled with climate change and changes in the distribution and flow of water—create conditions in which malaria's carrier mosquitoes thrive. The combination of these forces, Packard contends, makes the tropical regions today a perfect home for the disease.
Authoritative, fascinating, and eye-opening, this short history of malaria concludes with policy recommendations for improving control strategies and saving lives.
Image-Guided Interventions, a title in the Expert Radiology Series, brings you in-depth and advanced guidance on all of today’s imaging and procedural techniques. Whether you are a seasoned interventionalist or trainee, this single-volume medical reference book offers the up-to-the-minute therapeutic methods necessary to help you formulate the best treatment strategies for your patients. The combined knowledge of radiology experts from around the globe provides a broad range of treatment options and perspectives, equipping you to avoid complications and put today's best approaches to work in your practice.
"... the authors and editors have succeeded in providing a book that is both useful, instructive and practical" Reviewed by RAD Magazine, March 2015Formulate the best treatment plans for your patients with step-by-step instructions on important therapeutic radiology techniques, as well as discussions on equipment, contrast agents, pharmacologic agents, antiplatelet agents, and protocols.Make effective clinical decisions with the help of detailed protocols, classic signs, algorithms, and SIR guidelines.Make optimal use of the latest interventional radiology techniques with new chapters covering ablation involving microwave and irreversible electroporation; aortic endografts with fenestrated grafts and branch fenestrations; thoracic endografting (TEVAR); catheter-based cancer therapies involving drug-eluting beads; sacroiliac joint injections; bipedal lymphangiography; pediatric gastrostomy and gastrojejunostomy; and peripartum hemorrhage. Know what to look for and how to proceed with the aid of over 2,650 state-of-the-art images demonstrating interventional procedures, in addition to full-color illustrations emphasizing key anatomical structures and landmarks. Quickly reference the information you need through a functional organization highlighting indications and contraindications for interventional procedures, as well as tables listing the materials and instruments required for each. Access the fully searchable contents, online-only material, and all of the images online at Expert Consult.
The plague first sailed into San Francisco on the steamer Australia, on the day after New Year’s in 1900. Though the ship passed inspection, some of her stowaways—infected rats—escaped detection and made their way into the city’s sewer system. Two months later, the first human case of bubonic plague surfaced in Chinatown.
Initially in charge of the government’s response was Quarantine Officer Dr. Joseph Kinyoun. An intellectually astute but autocratic scientist, Kinyoun lacked the diplomatic skill to manage the public health crisis successfully. He correctly diagnosed the plague, but because of his quarantine efforts, he was branded an alarmist and a racist, and was forced from his post. When a second epidemic erupted five years later, the more self-possessed and charming Dr. Rupert Blue was placed in command. He won the trust of San Franciscans by shifting the government’s attack on the plague from the cool remove of the laboratory onto the streets, among the people it affected. Blue preached sanitation to contain the disease, but it was only when he focused his attack on the newly discovered source of the plague, infected rats and their fleas, that he finally eradicated it—truly one of the great, if little known, triumphs in American public health history.
With stunning narrative immediacy fortified by rich research, Marilyn Chase transports us to the city during the late Victorian age—a roiling melting pot of races and cultures that, nearly destroyed by an earthquake, was reborn, thanks in no small part to Rupert Blue and his motley band of pied pipers.
From the Hardcover edition.
Relive the heartwarming true story of the discovery of insulin as it's never been told before. Written with authentic detail and suspense, and featuring walk-ons by William Howard Taft, Woodrow Wilson, and Eli Lilly himself, among many others.
Award-winning medical historian Victoria A. Harden approaches the AIDS virus from philosophical and intellectual perspectives in the history of medical science, discussing the process of scientific discovery, scientific evidence, and how laboratories found the cause of AIDS and developed therapeutic interventions. Similarly, her book places AIDS as the first infectious disease to be recognized simultaneously worldwide as a single phenomenon.
After years of believing that vaccines and antibiotics would keep deadly epidemics away, researchers, doctors, patients, and the public were forced to abandon the arrogant assumption that they had conquered infectious diseases. By presenting an accessible discussion of the history of HIV/AIDS and analyzing how aspects of society advanced or hindered the response to the disease, AIDS at 30 illustrates for both medical professionals and general readers how medicine identifies and evaluates new infectious diseases quickly and what political and cultural factors limit the medical community’s response.
The manual is organised by body region and provides valuable insight into -
Patient pathology on MRI. Considerations when positioning both the patient and coil.Imaging planes. Anatomical image alignment.
This manual is a comprehensive highly visual reference to the planning and positioning of patients and coils in MR imaging. High quality imaging specific to patient pathology is encouraged through the focus on ‘considerations’ specific to coil and patient placement and imaging plane selection.Over 200 MR imagesFormulaic internal design assist use as clinical manual to MRI planningEvidence base provided where appropriate (cranial neurology)Image selection – assist learning principles that underpin good positioning and anatomical coverageExplores positioning of patient and coils specific to individual treatment requirementsEvolve website – image collection (over 200 MR images) and additional case studies
When Freud and Halsted began their experiments with cocaine in the 1880s, neither they, nor their colleagues, had any idea of the drug's potential to dominate and endanger their lives. An Anatomy of Addiction tells the tragic and heroic story of each man, accidentally struck down in his prime by an insidious malady: tragic because of the time, relationships, and health cocaine forced each to squander; heroic in the intense battle each man waged to overcome his affliction. Markel writes of the physical and emotional damage caused by the then-heralded wonder drug, and how each man ultimately changed the world in spite of it—or because of it. One became the father of psychoanalysis; the other, of modern surgery. Here is the full story, long overlooked, told in its rich historical context.
"The definitive social history of the medical profession in America....A monumental achievement."—H. Jack Geiger, M.D., New York Times Book Review
PKU (phenylketonuria) is a genetic disorder that causes severe cognitive impairment if it is not detected and treated with a strict and difficult diet. Programs to detect PKU and start treatment early are deservedly considered a public health success story. Some have traded on this success to urge expanded newborn screening, defend basic research in genetics, and confront proponents of genetic determinism. In this context, treatment for PKU is typically represented as a simple matter of adhering to a low-phenylalanine diet. In reality, the challenges of living with PKU are daunting.
In this first general history of PKU, a historian and a pediatrician explore how a rare genetic disease became the object of an unprecedented system for routine testing. The PKU Paradox is informed by interviews with scientists, clinicians, policymakers, and individuals who live with the disease. The questions it raises touch on ongoing controversies about newborn screening and what happens to blood samples collected at birth. -- M. Susan Lindee, University of Pennsylvania
Quickly grasp the radiology fundamentals you need to know—including basic science, image interpretation, and terminology—with the popular "programmed learning" approach, which promotes fast learning and reference.
Discern the nuances between modalitiesby comparing CT and MR images as well as traditional radiographs. View detailed clinical images covering all the image types you'll see on the boards including digital quality radiographs and an introduction of PET imaging, plus more advanced imaging such as CT and MRI than ever before.
Test your skills and simulate the exam experiencewith updated content aligned with the new MCQ-format Board exam for easy preparation and review.
Benefit the from more robust interactive offeringsin an e-book format.
Reference key information quickly and easily thanks to a consistent, user-friendly format and a unique two-part organization (radiologic approaches to specific joints and full description of the individual common arthritides) that facilitates finding the exact information you need for any joint in the body.Improve the accuracy of your diagnoses by interpreting radiographs and comparing them with correlating MRI images.
Benefit from the latest advancements and techniques found in completely revised and rewritten chapters.
Understand the nuances and subtleties of how arthritides present through over 350 high-quality digital images.
Several themes explored in the book illustrate ways in which non-medical factors influence our views of a disease and our reaction to it. One of these themes is the tendency to focus blame for the spread of a disease on a particular group (e.g., women, blacks, sinners). The balance between protecting the rights of individuals and protecting the public health, in issues such as whether to quarantine the infected and whether to require mandatory testing for the disease, is another theme. A third theme is the persistent reluctance of many Americans to discuss venereal disease openly because it involves sex, a subject that we are often not comfortable talking about.
The Handbook of MRI Technique has proved highly successful in guiding the uninitiated through scanning techniques and helping more experienced technologists to improve image quality. The third edition of this highly successful book has been fully revised and updated to consider new technologies and developments essential to good practice.
The book is split into two parts. Part 1 considers the main aspects of theory that relate to scanning and also includes practical tips on gating, equipment use, patient care and safety, and information on contrast media. Part 2 provides step by step instruction for examining each anatomical area, beginning with a basic anatomy section, followed by sections on indications, patient positioning, equipment, artefacts and tips on optimizing image quality. A section of problem-solving exercises completes the book.
Now in full color throughout with over 200 illustrations this book will continue to appeal to radiographers new to MRI and regular users who are looking for information on alternative techniques and suggestions on protocol modifications.
Completely revised and updated
Over 100 brand new photographs and line drawings
Written by technologists for technologists
With contributions from MRI technologists in the USA and Australia
Suitable for users of all types of MRI systems
"...the book does give a good overview of quality in imaging and to physicists performing controls it will be a valuable handbook." Reviewed by Jonn Terje Geitung on behalf of Journal of Acta Radiologica, April 2015Special icon identifies federal standards throughout the text to alert you to government regulations important to quality management.Updated material reflects content changes in the ARRT Quality Management Examination and better prepares you to pass the ARRT Advanced Level Examination in Quality Management.Includes QM for all imaging sciences so you can access QM information for all imaging modalities with just one resource.Step-by-step QM procedures offer instructions on how to evaluate equipment, and full-sized sample evaluation forms offer practice in documenting results. Strong pedagogy aids in comprehension.A practice exam on Evolve includes 200 randomizable practice exam questions for the ARRT advanced certification examination in QM, and includes answers with rationales. Student experiments on Evolve let you complete lab assignments and print out answers on a computer, and save instructors time because they do not have to create their own lab assignments. Instructor resources on Evolve make the text easier than ever for instructors to use. NEW! Updated quality management tools and procedures offer current practice guidelines and information.NEW! Coverage of new technologies, like cassette-based and cassette-less digital systems and wireless DR systems, helps improve familiarity with technological advances in radiography.UPDATED! Renovated Digital Image Receptors and Advanced Imaging Equipment chapter presents material more efficiently and includes the most current technology and practices.EXPANDED! Digital artifacts content increases familiarity with technological advances and adherence to necessary accreditation standards. UPDATED! Renovated Mammographic Quality Standard chapter reflects changes in technology and provides an overview of the latest technological practices.NEW! Content on CT exposure and the Image Gently program emphasizes safe and necessary imaging practices.NEW! Legislative content on Centers for Medicare and Medicaid Services (CMS), ICD-10 Coding, Health Information Exchanges, the Affordable Care Act, and MIPPA provides updates for legislative and relevant industry practices and concerns.NEW! Updated ACR accreditation requirements in CT and MRI improve practice compliance and understanding of necessary ACR accreditation requirement changes.
In this highly original account, Stepan sheds new light on the role of science in reformulating issues of race, gender, reproduction, and public health in an era when the focus on national identity was particularly intense. Drawing upon a rich body of evidence concerning the technical publications and professional meetings of Latin American eugenicists, she examines how they adapted eugenic principles to local contexts between the world wars. Stepan shows that Latin American eugenicists diverged considerably from their counterparts in Europe and the United States in their ideological approach and their interpretations of key texts concerning heredity.
Rosen, writing in the 1950s, may have had good reason to believe that infectious diseases would soon be conquered. But as Dr. Pascal James Imperato writes in the new foreword to this edition, infectious disease remains a grave threat. Globalization, antibiotic resistance, and the emergence of new pathogens and the reemergence of old ones, have returned public health efforts to the basics: preventing and controlling chronic and communicable diseases and shoring up public health infrastructures that provide potable water, sewage disposal, sanitary environments, and safe food and drug supplies to populations around the globe.
A revised introduction by Elizabeth Fee frames the book within the context of the historiography of public health past, present, and future, and an updated bibliography by Edward T. Morman includes significant books on public health history published between 1958 and 2014. For seasoned professionals as well as students, A History of Public Health is visionary and essential reading.