Drawn to the tiny Pacific atoll of Pingelap by intriguing reports of an isolated community of islanders born totally color-blind, Sacks finds himself setting up a clinic in a one-room island dispensary, where he listens to these achromatopic islanders describe their colorless world in rich terms of pattern and tone, luminance and shadow. And on Guam, where he goes to investigate the puzzling neurodegenerative paralysis endemic there for a century, he becomes, for a brief time, an island neurologist, making house calls with his colleague John Steele, amid crowing cockerels, cycad jungles, and the remains of a colonial culture.
The islands reawaken Sacks's lifelong passion for botany--in particular, for the primitive cycad trees, whose existence dates back to the Paleozoic--and the cycads are the starting point for an intensely personal reflection on the meaning of islands, the dissemination of species, the genesis of disease, and the nature of deep geologic time. Out of an unexpected journey, Sacks has woven an unforgettable narrative which immerses us in the romance of island life, and shares his own compelling vision of the complexities of being human.
From the Hardcover edition.
Quickly grasp the radiology fundamentals you need to know—including basic science, image interpretation, and terminology—with the popular "programmed learning" approach, which promotes fast learning and reference.
Discern the nuances between modalitiesby comparing CT and MR images as well as traditional radiographs. View detailed clinical images covering all the image types you'll see on the boards including digital quality radiographs and an introduction of PET imaging, plus more advanced imaging such as CT and MRI than ever before.
Test your skills and simulate the exam experiencewith updated content aligned with the new MCQ-format Board exam for easy preparation and review.
Benefit the from more robust interactive offeringsin an e-book format.
Reviews of the First Edition
“For anyone wishing to know what really goes on in their NMR experiments, I would highly recommend this book” – Chemistry World
“…I warmly recommend for budding NMR spectroscopists, or others who wish to deepen their understanding of elementary NMR theory or theoretical tools” – Magnetic Resonance in Chemistry
This new edition has been thoroughly revised and updated and has been redesigned to give the book a more contemporary look. As with previous editions it contains numerous examples, references and a series of exercises of increasing difficulty to encourage student understanding. Updates include: Increased coverage of MALDI and ESI, more detailed description of time of flight spectrometers, new material on isotope ratio mass spectrometry, and an expanded range of applications.
Mass Spectrometry, Third Edition is an invaluable resource for all undergraduate and postgraduate students using this technique in departments of chemistry, biochemistry, medicine, pharmacology, agriculture, material science and food science. It is also of interest for researchers looking for an overview of the latest techniques and developments.
This book guides the reader through the mathematics, physics and practical techniques needed to use telescopes (from small amateur models to the larger instruments installed in many colleges) and to observe objects in the sky. Mathematics to around Advanced Placement standard (US) or A level (UK) is assumed, although High School Diploma (US) or GCSE-level (UK) mathematics plus some basic trigonometry will suffice most of the time. Most of the physics and engineering involved is described fully and requires no prior knowledge or experience.
This is a ‘how to’ book that provides the knowledge and background required to understand how and why telescopes work. Equipped with the techniques discussed in this book, the observer will be able to operate with confidence his or her telescope and to optimize its performance for a particular purpose. In principle the observer could calculate his or her own predictions of planetary positions (ephemerides), but more realistically the observer will be able to understand the published data lists properly instead of just treating them as ‘recipes.’ When the observer has obtained measurements, he/she will be able to analyze them in a scientific manner and to understand the significance and meaning of the results.
“Telescopes and Techniques, 3rd Edition” fills a niche at the start of an undergraduate astronomer’s university studies, as shown by it having been widely adopted as a set textbook. This third edition is now needed to update its material with the many new observing developments and study areas that have come into prominence since it was published. The book concentrates on the knowledge needed to understand how small(ish) optical telescopes function, their main designs and how to set them up, plus introducing the reader to the many ways in which objects in the sky change their positions and how they may be observed. Both visual and electronic imaging techniques are covered, together with an introduction to how data (measurements) should be processed and analyzed. A simple introduction to radio telescopes is also included. Brief coverage of the most advanced topics of photometry and spectroscopy are included, but mainly to enable the reader to see some of the developments possible from the basic observing techniques covered in the main parts of the book.
Characterize abdominal masses and adenopathywith the aid of diffusion-weighted MR imaging.
See how gastrointestinal conditions presentwith more than 2,500 multi-modality, high-quality digital images that mirror the findings you're likely to encounter in practice. Make optimal use of the latest abdominal and gastrointestinal imaging techniques with new chapters on diffusion weighted MRI, perfusion MDCT and MRI, CT colonography, CT enterography and MR enterography—sophisticated cross-sectional imaging techniques that have dramatically improved the utility of CT and MR for detecting a host of pathologic conditions in the gastrointestinal tract.
Expert guidanceis right at your fingertips. Now optimized for use on mobile devices, this edition is perfect as an on-the-go resource for all abdominal imaging needs.
Effectively apply MR and CT perfusion, diffusion weighted imaging, PET/CT and PET/MRin evaluating tumor response to therapy.
Organic Structures from Spectra, Fifth Edition is a carefully chosen set of more than 280 structural problems employing the major modern spectroscopic techniques, a selection of 27 problems using 2D-NMR spectroscopy, more than 20 problems specifically dealing with the interpretation of spin-spin coupling in proton NMR spectra and 8 problems based on the quantitative analysis of mixtures using proton and carbon NMR spectroscopy. All of the problems are graded to develop and consolidate the student’s understanding of organic spectroscopy. The accompanying text is descriptive and only explains the underlying theory at a level which is sufficient to tackle the problems. The text includes condensed tables of characteristic spectral properties covering the frequently encountered functional groups.
The examples themselves have been selected to include all important common structural features found in organic compounds and to emphasise connectivity arguments. Many of the compounds were synthesised specifically for this purpose. There are many more easy problems, to build confidence and demonstrate basic principles, than in other collections.
The fifth edition of this popular textbook:
• includes more than 250 new spectra and more than 25 completely new problems;
• now incorporates an expanded suite of new problems dealing with the analysis of 2D NMR spectra (COSY, C H Correlation spectroscopy, HMBC, NOESY and TOCSY);
• has been expanded and updated to reflect the new developments in NMR and to retire older techniques that are no longer in common use;
• provides a set of problems dealing specifically with the quantitative analysis of mixtures using NMR spectroscopy;
• features proton NMR spectra obtained at 200, 400 and 600 MHz and 13C NMR spectra include DEPT experiments as well as proton-coupled experiments;
• contains 6 problems in the style of the experimental section of a research paper and two examples of fully worked solutions.
Organic Structures from Spectra, Fifth Edition will prove invaluable for students of Chemistry, Pharmacy and Biochemistry taking a first course in Organic Chemistry.
Nuclear Magnetic Resonance Spectroscopy
Reviews from earlier editions
“Your book is becoming one of the “go to” books for teaching structure determination here in the States. Great work!”
“…I would definitely state that this book is the most useful aid to basic organic spectroscopy teaching in existence and I would strongly recommend every instructor in this area to use it either as a source of examples or as a class textbook”.
Magnetic Resonance in Chemistry
“Over the past year I have trained many students using problems in your book - they initially find it as a task. But after doing 3-4 problems with all their brains activities... working out the rest of the problems become a mania. They get addicted to the problem solving and every time they solve a problem by themselves, their confident level also increases.”
“I am teaching the fundamentals of Molecular Spectroscopy and your books represent excellent sources of spectroscopic problems for students.”
This book incorporates recent technological advances in analytical pyrolysis methods especially useful for the characterization of 163 typical synthetic polymers. The book briefly reviews the instrumentation available in advanced analytical pyrolysis, and offers guidance to perform effectually this technique combining with gas chromatography and mass spectrometry. Main contents are comprehensive sample pyrograms, thermograms, identification tables, and representative mass spectra (MS) of pyrolyzates for synthetic polymers. This edition also highlights thermally-assisted hydrolysis and methylation technique effectively applied to 33 basic condensation polymers.Coverage of Py-GC/MS data of conventional pyrograms and thermograms of basic 163 kinds of synthetic polymers together with MS and retention index data for pyrolyzates, enabling a quick identificationAdditional coverage of the pyrograms and their related data for 33 basic condensation polymers obtained by the thermally-assisted hydrolysis and methylation techniqueAll compiled data measured under the same experimental conditions for pyrolysis, gas chromatography and mass spectrometry to facilitate peak identificationSurveyable instant information on two facing pages dedicated to the whole data of a given polymer sample
In the expanded second edition of Practical Guide and Spectral Atlas for Interpretive Near-Infrared Spectroscopy, the authors include new research, editorials, supplements, and molecular structural formulas, along with updated references and information on NIR spectra. The thoroughly updated and revised second edition offers a full library of color spectra in a larger format to ensure clarity and reader comprehension.
Providing a rich set of reference information required to interpret NIR spectra for research and industrial applications, this book:
Offers more than 300 figures representing all the major functional groups and their NIR frequency ranges Contains over 120 pages of tables and charts illustrating overlapping spectra Covers NIR spectra for organic compounds, including alkanes, carboxylic acids, amines, dienes, alkynes, heterocyclic compounds, amino acids, and aldehydes Provides comprehensive appendices with spectra-structure correlations, example spectra, and other useful data for interpreting NIR spectra
This unique book is organized into fifteen chapters covering all major areas of neurology including stroke, hemorrhage, neoplasms, epilepsy, trauma,neurodegenerative conditions, infectious diseases, pediatric syndromes, and much more. Each topic is introduced with a brief case scenario and image-baseddiagnosis, followed by bulleted introduction, clinical presentation, radiographic appearance and diagnostic hallmarks, differential diagnosis, andtreatment. Numerous examples throughout foster familiarity with key imaging findings and confidence interpreting MRI, CT, MRA, angiography, EEG, gross, andmicroscopic neuropathology images. Selected references for further study follow each topic.
Neurology Image-Based Clinical Reviewis an essential reference for medical students, practicing neurologists, residents looking to hone their knowledge, or anyone sharpening clinical andinterpretive skills for board or MOC review.
Key Features:Comes with free access to the fully-searchable downloadable e-book, including an image gallery Covers the full spectrum of neurologic disease with over 170 topics and more than 1500 images Includes chapters on commonly encountered problems and rare syndromes that may be missed in the clinic Presents the latest information on clinical presentation, diagnosis, treatment, and differential diagnoses of various neurological disorders Consistent format for easy readability and targeted review
Saunders’s analyses are informed by strands of cultural history and theory including art historical critiques of realist representation, Walter Benjamin’s concerns about violence in “mechanical reproduction,” and tropes of detective fiction such as intrigue, the case, and the culprit. Saunders analyzes the diagnostic “gaze” of medical personnel reading images at the viewbox, the two-dimensional images or slices of the human body rendered by the scanner, methods of archiving images, and the use of scans as pedagogical tools in clinical conferences. Bringing cloistered diagnostic practices into public view, he reveals the customs and the social and professional hierarchies that are formulated and negotiated around the weighty presence of the CT scanner. At the same time, by returning throughout to the nineteenth-century ideas of detection and scientific authority that inform contemporary medical diagnosis, Saunders highlights the specters of the past in what appears to be a preeminently modern machine.
Core interventional skills;Essential equipment; Principles of Vascular intervention and Principles of Non-vascular intervention.
Increased emphasison Interventional Oncology including the management of cancer and its complications.
Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Nearly 300 line diagrams and photos illustrate procedures, including anatomical and technical points.
Tip boxeshighlight key facts and technical recommendations.
Troubleshooting guideshelp get you back on track when things don’t go exactly as planned.
Warning boxeshighlight common and important pitfalls.
This book offers a comprehensive guide to the theory and practice of analyzing electrical brain signals. It explains the conceptual, mathematical, and implementational (via Matlab programming) aspects of time-, time-frequency- and synchronization-based analyses of magnetoencephalography (MEG), electroencephalography (EEG), and local field potential (LFP) recordings from humans and nonhuman animals. It is the only book on the topic that covers both the theoretical background and the implementation in language that can be understood by readers without extensive formal training in mathematics, including cognitive scientists, neuroscientists, and psychologists.
Readers who go through the book chapter by chapter and implement the examples in Matlab will develop an understanding of why and how analyses are performed, how to interpret results, what the methodological issues are, and how to perform single-subject-level and group-level analyses. Researchers who are familiar with using automated programs to perform advanced analyses will learn what happens when they click the “analyze now” button.
The book provides sample data and downloadable Matlab code. Each of the 38 chapters covers one analysis topic, and these topics progress from simple to advanced. Most chapters conclude with exercises that further develop the material covered in the chapter. Many of the methods presented (including convolution, the Fourier transform, and Euler's formula) are fundamental and form the groundwork for other advanced data analysis methods. Readers who master the methods in the book will be well prepared to learn other approaches.
* The first reference work on named reactions to present colored schemes for easier understanding
* 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples
* An opening list of abbreviations includes both structures and chemical names
* Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works
* Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools
* Extensive index quickly locates information using words found in text and drawings
Designed for those new to FTIR, but with enough reference material to appeal to journeyman and expert spectroscopists, this book does not demand any extensive familiarity with chemistry or physics. Specializing in concise and comprehensible explanations of FTIR topics, the author introduces the field of infrared spectroscopy, including the strengths and weaknesses of FTIR as a chemical analysis technique. He then describes the instrument itself and explores topics such as how an interferometer generates a spectrum, optimization of spectral quality, and which tests are used to monitor instrument health.
The book discusses how to properly use spectral processing to increase the information of a spectrum without damaging the data and takes considerable care in instructing on sample preparation, as good sample preparation constitutes half the battle in extracting good data. The final chapters examine single analyte quantitative analysis and conclude with an overview of infrared microscopy.
Drawing on the experience and knowledge of the author as both a professor and practitioner, Fundamentals of Fourier Transform Infrared Spectroscopy offers up-to-date information given in clear, easily understood language to appeal to beginner and expert spectroscopists alike. The author maintains a website and blog with supplemental material. His training course schedule is also available online.
The book assumes only a basic knowledge of complex numbers and matrices, and provides the reader with numerous worked examples and exercises to encourage understanding. With the explicit aim of carefully developing the subject from the beginning, the text starts with coverage of quarks and nucleons and progresses through to a detailed explanation of several important NMR experiments, including NMR imaging, COSY, NOESY and TROSY.
Completely revised and updated, the Second Edition features new material on the properties and distributions of isotopes, chemical shift anisotropy and quadrupolar interactions, Pake patterns, spin echoes, slice selection in NMR imaging, and a complete new chapter on the NMR spectroscopy of quadrupolar nuclei. New appendices have been included on Euler angles, and coherence selection by field gradients. As in the first edition, all material is heavily supported by graphics, much of which is new to this edition.
Written for undergraduates and postgraduate students taking a first course in NMR spectroscopy and for those needing an up-to-date account of the subject, this multi-disciplinary book will appeal to chemical, physical, material, life, medical, earth and environmental scientists. The detailed physical insights will also make the book of interest for experienced spectroscopists and NMR researchers.
• An accessible and carefully written introduction, designed to help students to fully understand this complex and dynamic subject
• Takes a multi-disciplinary approach, focusing on basic principles and concepts rather than the more practical aspects
• Presents a strong pedagogical approach throughout, with emphasis placed on individual spins to aid understanding
• Includes numerous worked examples, problems, further reading and additional notes
Praise from the reviews of the First Edition:
"This is an excellent book... that many teachers of NMR spectroscopy will cherish... It deserves to be a ‘classic’ among NMR spectroscopy texts." NMR IN BIOMEDICINE
"I strongly recommend this book to everyone…it is probably the best modern comprehensive description of the subject." ANGEWANDTE CHEMIE, INTERNATIONAL EDITION
The field of Cardiovascular CT has experienced continued rapid evolution due to: 1) advances in technology, 2) expanded spectrum of cardiovascular applications and 3) significant growth in published data including large prospective multicenter studies.
As increasing numbers have access to cardiac CT scanners, this book provides all the relevant information on this modality. This is an extensive update of the previous edition bringing the reader up-to-date with the immense amount of updated content in the discipline.
All common body MR imaging content is covered, along with discussion of how physics, techniques, hardware, and artifacts affect results.
Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Newly streamlined format helps you retrieve important information more quickly.
Extensively revised contenton the liver, including new MRI contrast agents; new coverage of the spleen; and new safety tips and guidelines keep you up to date.
New chapterson GI imaging, the prostate, and the male genitourinary system make this a one-stop reference to address the full range of body MRI.
The Fourth Edition includes new or expanded sections and information for:
* PET/MR, including the attenuation correction method and its quality control tests;
* accreditation of nuclear medicine and PET facilities;
* solid state digital cameras;
* time of flight and scatter correction techniques;
* CT scanners and attenuation correction in SPECT/CT;
* partial volume effects;
* quality control of CT scanners;
* ion chamber survey meters, proportional counters, and G-M counters.
Includes new Take-Home-Points at the end of each chapter for easy recall and review.
Theory and Applications of Heat Transfer in Humans 2V Set offers a reference to the field of heating and cooling of tissue, and associated damage. The author—a noted expert in the field—presents, in this book, the fundamental physics and physiology related to the field, along with some of the recent applications, all in one place, in such a way as to enable and enrich both beginner and advanced readers. The book provides a basic framework that can be used to obtain ‘decent’ estimates of tissue temperatures for various applications involving tissue heating and/or cooling, and also presents ways to further develop more complex methods, if needed, to obtain more accurate results. The book is arranged in three sections: The first section, named ‘Physics’, presents fundamental mathematical frameworks that can be used as is or combined together forming more complex tools to determine tissue temperatures; the second section, named ‘Physiology’, presents ideas and data that provide the basis for the physiological assumptions needed to develop successful mathematical tools; and finally, the third section, named ‘Applications’, presents examples of how the marriage of the first two sections are used to solve problems of today and tomorrow.
This important text is the vital resource that:Offers a reference book in the field of heating and cooling of tissue, and associated damage. Provides a comprehensive theoretical and experimental basis with biomedical applications Shows how to develop and implement both, simple and complex mathematical models to predict tissue temperatures Includes simple examples and results so readers can use those results directly or adapt them for their applications
Designed for students, engineers, and other professionals, a comprehensive text to the field of heating and cooling of tissue that includes proven theories with applications. The author reveals how to develop simple and complex mathematical models, to predict tissue heating and/or cooling, and associated damage.
The possible applications of enzymes are enormous. Years of development have seen many enzymes brought onto the market, but they are still expensive to use. Therefore, their efficient application is a prerequisite for common usage. One of the main factors for this efficiency is the stability of the enzymes. The topics thus ranged from the extensive fundamental thermodynamic knowledge gathered in academic research to the practical applied knowledge built up in industry during the time that enzymes have been produced commercially.
The subject Stability and Stabilization of Enzymes was discussed from various points of view, as was reflected in the themes of the symposium sessions. In the session on Fundamentals of Enzyme Stabilisation the thermodynamic background of the phenomenon was highlighted. In yet another session, the recently developed analytical tools to measure enzyme stability and stabilisation were discussed. Further sessions comprised the physical, chemical and biological ways to obtain enzyme stabilisation and finally, the industrial practice of enzyme stabilisation was treated by representatives of the world's most important enzyme producers. The book will be of interest to researchers in universities and industry in the fields of biochemistry, enzymology and biotechnology.
The atlas is organized into five chapters. In Chapters one, cases received closure of congenital and acquired cardiac defects are described. Transcatheter aortic valve implantation and its complications are discussed in Chapter two and three. Chapter four details the valve-in-valve therapy. Chapter five covers MitraClip therapy. It offers readers an insider’s view of 3D transesophageal echocardiography in structural heart disease interventions and to refresh their clinical work.
important for determining the 3D-structure of molecules.
This new edition of the popular classic has a clear style and a highly practical, mostly non-mathematical approach. Many examples are taken from organic and organometallic chemistry, making this book an invaluable guide to undergraduate and graduate students of organic chemistry, biochemistry, spectroscopy or physical chemistry, and to researchers using this well-established and extremely important technique. Problems and solutions are included.
The novelty of this book relates to its intended practical use and focus on state-of-the-art cardiac MRI techniques that span both the clinical and basic science fields. In comparison and contrast to other pre-existing books, this book will distinguish from others for its practical usefulness and conciseness. Correspondingly, the book will be used as a handbook (quick reference) for new starters or people who would like to establish state-of-the-art cardiac MRI techniques in their institutions. Given the historical evolution of technique development in MRI, the clinical and basic science topics will be described separately. However, in instances where basic science development complemented (or is envisaged to complement) clinical development (e.g., Diffusion MRI and tractography), every effort will be made to allow a comprehensive review and associations of the clinical/basic science subfields.
The fifth edition is thoroughly updated and includes new or expanded chapters on nuclear medicine, pediatric radiology, and emerging imaging techniques. A comprehensive question bank, which functions as a valuable self-assessment tool, concludes the book.
Compared to conventional Raman microscopy, coherent Raman scattering (CRS) allows label-free imaging of living cells and tissues at video rate by enhancing the weak Raman signal through nonlinear excitation. Edited by pioneers in the field and with contributions from a distinguished team of experts, Coherent Raman Scattering Microscopy explains how CRS can be used to obtain a point-by-point chemical map of live cells and tissues.
In color throughout, the book starts by establishing the foundation of CRS microscopy. It discusses the principles of nonlinear optical spectroscopy, particularly coherent Raman spectroscopy, and presents the theories of contrast mechanisms pertinent to CRS microscopy. The text then provides important technical aspects of CRS microscopy, including microscope construction, detection schemes, and data analyses. It concludes with a survey of applications that demonstrate how CRS microscopy has become a valuable tool in biomedicine.
Due to its label-free, noninvasive examinations of living cells and organisms, CRS microscopy has opened up exciting prospects in biology and medicine—from the mapping of 3D distributions of small drug molecules to identifying tumors in tissues. An in-depth exploration of the theories, technology, and applications, this book shows how CRS microscopy has impacted human health and will deepen our understanding of life processes in the future.