Chairman: Dennis Murphy, 1986
Depression is a common and often debilitating affective disorder. Attempts to develop effective antidepressants have a long history, but many questions remain about the mechanisms of action of such treatments and about the aetiology and pathophysiology of depression itself. Early observations centred attention on central monoamine systems, and animal studies suggested that changes in beta-adrenoceptor responsiveness were a common effect of antidepressant therapies. More recent research has encompassed many different central and peripheral receptors, time-dependent adaptational events at synapses, and the functional significance of changes in neurotransmitter systems in both humans and experimental animals. Such pharmacological studies aimed ultimately at elucidating the neurochemical basis of depression and of promoting new therapeutic approaches, provide the focus of this symposium volume. Many different methods of investigating the links between monoamine systems, depression and antidepressant treatments are described. Recent studies of receptors and of monoamine uptake sites in the brain and the periphery (e.g. in platelets and fibroblasts) are reviewed, with emphasis on alpha and beta adrenoceptors, [3H]imipramine-binding sites and serotonin receptors. The results of monitoring amine metabolites in cerebrospinal fluid and of measuring neuroendocrine, physiological and behavioural responses to pharmacological challenge are presented, providing information on monoaminergic function in depressed patients and experimental animals before, during and after treatment with antidepressant drugs or electroconvulsive shock. Genetic influences on receptor density are also discussed, as is the relevance to human depressive illness of animal models, including stress-induced behavioural depression in rats and responses to social stressors in rhesus monkeys.
This book should be of interest to neuropharmacologists, psychopharmacologists, clinical pharmacologists, behavioural scientists, psychiatrists and neuroscientists.
Chairman: Stuart B. Levy, 1997
Over the last 50 years, the rapid increase in the use of antibiotics, not only in people, but also in animal husbandry and agriculture, has delivered a selection unprecedented in the history of evolution. Consequently, society is facing one of its gravest public health problems-the emergence of infectious bacteria with resistance to many, and in some cases all, available antibiotics. This book brings together a multidisciplinary group of experts to discuss this problem. It begins by examining the origins of resistance and goes on to look at how the use of antibiotics in human medicine and farming/agriculture has selected for resistant bacteria. Separate chapters describe the evolution of resistance determinants and how these are spread both within and between bacterial species. Finally, the book contains discussions on strategies for countering the threat of antibiotic resistance. A major re-thinking of our approach to the treatment of infectious diseases is proposed-that antibiotic resistance should be seen as a problem created by the disruption of normal microbial ecology. To restore efficacy to earlier antibiotics, and to maintain the success of new antibiotics that are introduced, we need to use these drugs in a way that ensures an ecological balance that favours the predominance of susceptible bacteria.
Dr. Fuhrman doesn’t believe the secret to staying healthy lies in medical care—rather, the solution is to change the way we eat. With more than 85 plant-based recipes, a two-week menu plan, and lists of super foods that boost immunity, Dr. Fuhrman’s proven strategies combine the latest data from clinical tests, nutritional research, and results from thousands of patients .
Fans of Alejandro Junger’s Clean, Mark Hyman’s Ultraprevention, and T. Colin Campbell’s The China Study will appreciate Dr. Fuhrman’s practical plan to prevent and reverse disease—no shots, drugs or sick days required.
At last, a breakthrough program to combat the rising diabetes epidemic and help millions of diabetics, as well as those suffering with high blood pressure and heart disease. Joel Fuhrman, M.D. Research director of the Nutritional Research Foundation, shows you how to live a long, healthy, and happy life—disease free. He offers a complete health transformation, starting with a diet with a high nutrient-per-calorie ratio that can be adapted for individual needs.
Dr. Fuhrman makes clear that we don’t have to “control” diabetes. Patients can choose to follow better nutritional guidelines that will control it for them, even before they have lost excess weight. The end result is a medical breakthrough—a comprehensive reversal of the disease.
Paleo for Beginners will show you how to adopt a paleo lifestyle in order to feel healthy, lose weight, and increase your energy level. With Paleo for Beginners, start enjoying the best health of your life today--all while losing weight and decreasing your odds of diabetes, hypertension, heart disease, cancer, osteoporosis, and many other modern health maladies.
Paleo for Beginners is a comprehensive yet concise guide to embracing the Paleo lifestyle, walking readers through a successful Paleo diet in a straightforward, easy-to-read format.
Successfully make the transition to a Paleo lifestyle with a 7-day, step-by-step plan for beginnersSet yourself up for success with the Paleo shopping guide and a list of 117 Paleo-recommended foods (and an extensive list of what food items you should avoid).Enjoy Paleo-friendly versions of 99 mouthwatering recipes for every meal. Recipes include Eggs Benedict Paleo Style, High-Protein Grain-Free Burgers, Chicken Avocado Wraps, and Paleo Waffles. Starting a new diet can be difficult, but with Paleo for Beginners learning how to do so shouldn't be.
The next big human pandemic—the next disease cataclysm, perhaps on the scale of AIDS or the 1918 influenza—is likely to be caused by a new virus coming to humans from wildlife. Experts call such an event “spillover” and they warn us to brace ourselves. David Quammen has tracked this subject from the jungles of Central Africa, the rooftops of Bangladesh, and the caves of southern China to the laboratories where researchers work in space suits to study lethal viruses. He illuminates the dynamics of Ebola, SARS, bird flu, Lyme disease, and other emerging threats and tells the story of AIDS and its origins as it has never before been told. Spillover reads like a mystery tale, full of mayhem and clues and questions. When the Next Big One arrives, what will it look like? From which innocent host animal will it emerge? Will we be ready?
After visits to world-renowned researchers at the Salk Institute, in La Jolla, California, and the National Institute on Aging, in Baltimore, and completing interviews with a dozen other clinical experts—plus poring over the copious amounts of new research in the fascinating field of intermittent fasting, Zinczenko and Moore came up with a plan that they themselves tried, and they engaged 2,000 people for a test panel. Based on their interviews, research, and test panel results, they determined that readers can lose remarkable amounts of weight eating the foods they like best—as long as they eat within a set 8-hour time period. Fasting is, of course, an ancient spiritual and health practice, but it's also a way to sidestep many of the ills of the modern world—including diabetes, heart disease, and cognitive impairment.
Zinczenko and Moore demonstrate how simply observing this timed-eating strategy, even just three days a week, will reset a dieter's metabolism so that he or she can enter fat-burning mode first thing in the morning—and stay there all day long. And by focusing on eight critical, nutrient-rich Powerfoods, readers build in a second layer of protection against Alzheimer's, heart disease, and even the common cold.
In the book, readers will find motivating strategies, delicious recipes, and an 8-minute workout routine to maximize calorie burn. The 8-Hour Diet promises to strip away unwanted pounds and give readers the focus and willpower they need to reach their goals for weight loss and life.
Whether you are seeing a doctor, nutritionist, or a trainer, all of them advise to eat more protein. Foods, drinks, and supplements are loaded with extra protein. Many people use protein for weight control, to gain or lose pounds, while others believe it gives them more energy and is essential for a longer, healthier life. Now, Dr. Garth Davis, an expert in weight loss asks, “Is all this protein making us healthier?”
The answer, he emphatically argues, is NO. Too much protein is actually making us sick, fat, and tired, according to Dr. Davis. If you are getting adequate calories in your diet, there is no such thing as protein deficiency. The healthiest countries in the world eat far less protein than we do and yet we have an entire nation on a protein binge getting sicker by the day.
As a surgeon treating obese patients, Dr. Davis was frustrated by the ever-increasing number of sick and overweight patients, but it wasn't until his own health scare that he realized he could do something about it. Combining cutting-edge research, with his hands-on patient experience and his years dedicated to analyzing studies of the world’s longest-lived populations, this explosive, groundbreaking book reveals the truth about the dangers of protein and shares a proven approach to weight loss, health, and longevity.
The EAT FAT GET THIN diet will allow you to do just that: the emphasis being on what you eat rather than how many calories the food contains. The rules are simple: keep your carbohydrates to a minimum by cutting out bread, potatoes and cereals, leave out the sugar, eat only the good fats and concentrate on protein rich foods.
The beauty of the EAT FAT GET THIN diet is that you will never go hungry. EAT FAT GET THIN proves that the diet on which it is most difficult to lose weight is a low-fat high carbohydrate diet. In fact, a century of studies and medical trials has consistently demonstrated that for safe wight loss a high fat diet is best.
EAT FAT GET THIN is the diet on which you can reach your desired weight easily and maintain it - for life.
No matter what kind of lifestyle you lead, no matter what your bad habits, whether you’re a smoker, a couch potato, or a marshmallow addict, it’s never too late to start living a healthy life. You do not have to be destined to a certain health outcome because your parents were on the same path, or because you think you’ve already done the damage. And you can even change the function of your genes through your lifestyle choices.
Bestselling author and renowned chief wellness officer of the Cleveland Clinic gives readers the tools they need to change their habits and get a new start. Dr. Roizen addresses all the areas that contribute to total-body wellness—including nutrition, exercise, sex, stress, sleep, and the brain. He shares his seven simple secrets—grounded in cutting-edge scientific research and culled from experience coaching thousands—to healthy living and provides concrete strategies that anyone can implement, regardless of age or health. “If you ever wanted a second chance at redoing your life, reimagining the areas that don’t work—body, mind, relationships, and more—This Is Your Do-Over is your guide” (Mark Hyman, MD, #1 New York Times bestselling author).
The DASH diet has been named by U.S. News & World Report year after year as its #1 choice in Best Diets Overall, Best Diets for Healthy Eating, and Best Diabetes Diets.
Based on research by the National Institutes of Health, and endorsed by top-tier medical institutions like the Mayo Clinic and the American Heart Association, the DASH diet is a scientifically proven method to lose weight, lower blood pressure, lower cholesterol levels, and a reduce your risk of diabetes.
In The DASH Diet Health Plan, best-selling health and nutrition author John Chatham compiles the findings of the medical and scientific community, alongside dozens of DASH diet recipes, to make it easy to put the DASH diet into action.
With The DASH Diet Health Plan you will get:
· 99 DASH diet recipes for every meal, including hearty breakfasts and satisfying dinners
· A guide to 147 Dash diet foods, ranging from meats and seafood to sweets
· Tips for navigating the grocery store and choosing the right DASH diet foods for you and your family
· 28-day DASH to Fitness workout plan, which provides step-by-step exercise routines to accelerate your weight loss and jump-start your health regimen
· 14-day Menu Planner to help you easily get started on the DASH diet
Developed by pioneering British MD Dr. Natasha Campbell-McBride, who provides the book’s Foreword, Gut and Psychology Syndrome (GAPS) refers to disorders, including ADD/ADHD, autism, addictions, depression, and obsessive-compulsive disorder, stemming from or exacerbated by leaky gut and dysbiosis. GAPS also refers to chronic gut-related physical conditions, including celiac disease, rheumatoid arthritis, diabetes type one, and Crohn’s disease, as well as asthma, eczema, allergies, thyroid disorders, and more. An evolution of the Specific Carbohydrate Diet, the GAPS Diet will appeal to followers of the Paleo Diet, who are still struggling for optimum health, as well as anyone interested in the health benefits of fermentation or the Weston A. Price approach to nutrition.
In The Heal Your Gut Cookbook, readers will learn about the key cooking techniques and ingredients that form the backbone of the GAPS Diet: working with stocks and broths, soaking nuts and seeds, using coconut, and culturing raw dairy. The authors offer encouraging, real-life perspectives on the life-changing improvements to the health of their families by following this challenging, but powerful, diet.
The GAPS Diet is designed to restore the balance between beneficial and pathogenic intestinal bacteria and seal the gut through the elimination of grains, processed foods, and refined sugars and the carefully sequenced reintroduction of nutrient-dense foods, including bone broths, raw cultured dairy, certain fermented vegetables, organic pastured eggs, organ meats, and more.
The Heal Your Gut Cookbook is a must-have if you are following the GAPS Diet, considering the GAPS Diet, or simply looking to improve your digestive health and—by extension—your physical and mental well-being.