Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years.
The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist.
From the Persian Queen Atossa, whose Greek slave may have cut off her diseased breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease.
Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
A New York Times Notable Book
A Washington Post and Seattle Times Best Book of the Year
From the Pulitzer Prize-winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle).
“Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.
“Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome.
“A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).
History is about so much more than memorizing facts. It is, as more than half of the word suggests, about the story. And, told in the right way, it is the greatest one ever written: Good and evil, triumph and tragedy, despicable acts of barbarism and courageous acts of heroism.
The things you’ve never learned about our past will shock you. The reason why gun control is so important to government elites can be found in a story about Athens that no one dares teach. Not the city in ancient Greece, but the one in 1946 Tennessee. The power of an individual who trusts his gut can be found in the story of the man who stopped the twentieth hijacker from being part of 9/11. And a lesson on what happens when an all-powerful president is in need of positive headlines is revealed in a story about eight saboteurs who invaded America during World War II.
Miracles and Massacres is history as you’ve never heard it told. It’s incredible events that you never knew existed. And it’s stories so important and relevant to today that you won’t have to ask, Why didn’t they teach me this? You will instantly know. If the truth shall set you free, then your freedom begins on page one of this book. By the end, your understanding of the lies and half-truths you’ve been taught may change, but your perception of who we are as Americans and where our country is headed definitely will.
“A thrilling account of the modern material world.” —Wall Street Journal
"Miodownik, a materials scientist, explains the history and science behind things such as paper, glass, chocolate, and concrete with an infectious enthusiasm." —Scientific American
Why is glass see-through? What makes elastic stretchy? Why does any material look and behave the way it does? These are the sorts of questions that renowned materials scientist Mark Miodownik constantly asks himself. Miodownik studies objects as ordinary as an envelope and as unexpected as concrete cloth, uncovering the fascinating secrets that hold together our physical world. In Stuff Matters, Miodownik explores the materials he encounters in a typical morning, from the steel in his razor to the foam in his sneakers. Full of enthralling tales of the miracles of engineering that permeate our lives, Stuff Matters will make you see stuff in a whole new way.
"Stuff Matters is about hidden wonders, the astonishing properties of materials we think boring, banal, and unworthy of attention...It's possible this science and these stories have been told elsewhere, but like the best chocolatiers, Miodownik gets the blend right." —New York Times Book Review
"The tragedies keep coming. As we reel from the latest horror . . ."
So begins a new epilogue, illustrating how Columbine became the template for nearly two decades of "spectacle murders." It is a false script, seized upon by a generation of new killers. In the wake of Newtown, Aurora, and Virginia Tech, the imperative to understand the crime that sparked this plague grows more urgent every year.
What really happened April 20, 1999? The horror left an indelible stamp on the American psyche, but most of what we "know" is wrong. It wasn't about jocks, Goths, or the Trench Coat Mafia. Dave Cullen was one of the first reporters on scene, and spent ten years on this book-widely recognized as the definitive account. With a keen investigative eye and psychological acumen, he draws on mountains of evidence, insight from the world's leading forensic psychologists, and the killers' own words and drawings-several reproduced in a new appendix. Cullen paints raw portraits of two polar opposite killers. They contrast starkly with the flashes of resilience and redemption among the survivors.
When a deadly diphtheria epidemic swept through Nome, Alaska, in 1925, the local doctor knew that without a fresh batch of antitoxin, his patients would die. The lifesaving serum was a thousand miles away, the port was icebound, and planes couldn't fly in blizzard conditions—only the dogs could make it. The heroic dash of dog teams across the Alaskan wilderness to Nome inspired the annual Iditarod Trail Sled Dog Race and immortalized Balto, the lead dog of the last team whose bronze statue still stands in New York City's Central Park. This is the greatest dog story, never fully told until now.
Witches, Midwives, and Nurses, first published by the Feminist Press in 1973, is an essential book about the corruption of the medical establishment and its historic roots in witch hunters. In this new edition, Barbara Ehrenreich and Deirdre English have written an entirely new chapter that delves into the current fascination with and controversies about witches, exposing our fears and fantasies. They build on their classic exposé on the demonization of women healers and the political and economic monopolization of medicine. This quick history brings us up-to-date, exploring today's changing attitudes toward childbirth, alternative medicine, and modern-day witches.
Bellevue Hospital, on New York City's East Side, occupies a colorful and horrifying place in the public imagination: a den of mangled crime victims, vicious psychopaths, assorted derelicts, lunatics, and exotic-disease sufferers. In its two and a half centuries of service, there was hardly an epidemic or social catastrophe—or groundbreaking scientific advance—that did not touch Bellevue.
David Oshinsky, whose last book, Polio: An American Story, was awarded a Pulitzer Prize, chronicles the history of America's oldest hospital and in so doing also charts the rise of New York to the nation's preeminent city, the path of American medicine from butchery and quackery to a professional and scientific endeavor, and the growth of a civic institution. From its origins in 1738 as an almshouse and pesthouse, Bellevue today is a revered public hospital bringing first-class care to anyone in need. With its diverse, ailing, and unprotesting patient population, the hospital was a natural laboratory for the nation's first clinical research. It treated tens of thousands of Civil War soldiers, launched the first civilian ambulance corps and the first nursing school for women, pioneered medical photography and psychiatric treatment, and spurred New York City to establish the country's first official Board of Health.
As medical technology advanced, "voluntary" hospitals began to seek out patients willing to pay for their care. For charity cases, it was left to Bellevue to fill the void. The latter decades of the twentieth century brought rampant crime, drug addiction, and homelessness to the nation's struggling cities—problems that called a public hospital's very survival into question. It took the AIDS crisis to cement Bellevue's enduring place as New York's ultimate safety net, the iconic hospital of last resort. Lively, page-turning, fascinating, Bellevue is essential American history.
In Killer Fat, Natalie Boero examines how and why obesity emerged as a major public health concern and national obsession in recent years. Using primary sources and in-depth interviews, Boero enters the world of bariatric surgeries, Weight Watchers, and Overeaters Anonymous to show how common expectations of what bodies are supposed to look like help to determine what sorts of interventions and policies are considered urgent in containing this new kind of disease.
Boero argues that obesity, like the traditional epidemics of biological contagion and mass death, now incites panic, a doomsday scenario that must be confronted in a struggle for social stability. The “war” on obesity, she concludes, is a form of social control. Killer Fat ultimately offers an alternate framing of the nation’s obesity problem based on the insights of the “Health at Every Size” movement.
Short-listed for the 2018 Wellcome Book Prize
A Top 10 Science Book of Fall 2017, Publishers Weekly
A Best History Book of 2017, The Guardian
"Warning: She spares no detail!" —Erik Larson, bestselling author of Dead Wake
In The Butchering Art, the historian Lindsey Fitzharris reveals the shocking world of nineteenth-century surgery and shows how it was transformed by advances made in germ theory and antiseptics between 1860 and 1875. She conjures up early operating theaters—no place for the squeamish—and surgeons, who, working before anesthesia, were lauded for their speed and brute strength. These pioneers knew that the aftermath of surgery was often more dangerous than patients’ afflictions, and they were baffled by the persistent infections that kept mortality rates stubbornly high. At a time when surgery couldn’t have been more hazardous, an unlikely figure stepped forward: a young, melancholy Quaker surgeon named Joseph Lister, who would solve the riddle and change the course of history.
Fitzharris dramatically reconstructs Lister’s career path to his audacious claim that germs were the source of all infection and could be countered by a sterilizing agent applied to wounds. She introduces us to Lister’s contemporaries—some of them brilliant, some outright criminal—and leads us through the grimy schools and squalid hospitals where they learned their art, the dead houses where they studied, and the cemeteries they ransacked for cadavers.
Eerie and illuminating, The Butchering Art celebrates the triumph of a visionary surgeon whose quest to unite science and medicine delivered us into the modern world.
Updated with a new preface and an epilogue analyzing developments since the early 1980s, this new edition of The Social Transformation of American Medicine is a must-read for anyone concerned about the future of our fraught healthcare system.
When Freud and Halsted began their experiments with cocaine in the 1880s, neither they, nor their colleagues, had any idea of the drug's potential to dominate and endanger their lives. An Anatomy of Addiction tells the tragic and heroic story of each man, accidentally struck down in his prime by an insidious malady: tragic because of the time, relationships, and health cocaine forced each to squander; heroic in the intense battle each man waged to overcome his affliction. Markel writes of the physical and emotional damage caused by the then-heralded wonder drug, and how each man ultimately changed the world in spite of it—or because of it. One became the father of psychoanalysis; the other, of modern surgery. Here is the full story, long overlooked, told in its rich historical context.
From Russia to Bengal to Palm Beach, Randall Packard’s far-ranging narrative traces the natural and social forces that help malaria spread and make it deadly. He finds that war, land development, crumbling health systems, and globalization—coupled with climate change and changes in the distribution and flow of water—create conditions in which malaria's carrier mosquitoes thrive. The combination of these forces, Packard contends, makes the tropical regions today a perfect home for the disease.
Authoritative, fascinating, and eye-opening, this short history of malaria concludes with policy recommendations for improving control strategies and saving lives.
Award-winning medical historian Victoria A. Harden approaches the AIDS virus from philosophical and intellectual perspectives in the history of medical science, discussing the process of scientific discovery, scientific evidence, and how laboratories found the cause of AIDS and developed therapeutic interventions. Similarly, her book places AIDS as the first infectious disease to be recognized simultaneously worldwide as a single phenomenon.
After years of believing that vaccines and antibiotics would keep deadly epidemics away, researchers, doctors, patients, and the public were forced to abandon the arrogant assumption that they had conquered infectious diseases. By presenting an accessible discussion of the history of HIV/AIDS and analyzing how aspects of society advanced or hindered the response to the disease, AIDS at 30 illustrates for both medical professionals and general readers how medicine identifies and evaluates new infectious diseases quickly and what political and cultural factors limit the medical community’s response.
The plague first sailed into San Francisco on the steamer Australia, on the day after New Year’s in 1900. Though the ship passed inspection, some of her stowaways—infected rats—escaped detection and made their way into the city’s sewer system. Two months later, the first human case of bubonic plague surfaced in Chinatown.
Initially in charge of the government’s response was Quarantine Officer Dr. Joseph Kinyoun. An intellectually astute but autocratic scientist, Kinyoun lacked the diplomatic skill to manage the public health crisis successfully. He correctly diagnosed the plague, but because of his quarantine efforts, he was branded an alarmist and a racist, and was forced from his post. When a second epidemic erupted five years later, the more self-possessed and charming Dr. Rupert Blue was placed in command. He won the trust of San Franciscans by shifting the government’s attack on the plague from the cool remove of the laboratory onto the streets, among the people it affected. Blue preached sanitation to contain the disease, but it was only when he focused his attack on the newly discovered source of the plague, infected rats and their fleas, that he finally eradicated it—truly one of the great, if little known, triumphs in American public health history.
With stunning narrative immediacy fortified by rich research, Marilyn Chase transports us to the city during the late Victorian age—a roiling melting pot of races and cultures that, nearly destroyed by an earthquake, was reborn, thanks in no small part to Rupert Blue and his motley band of pied pipers.
From the Hardcover edition.
Relive the heartwarming true story of the discovery of insulin as it's never been told before. Written with authentic detail and suspense, and featuring walk-ons by William Howard Taft, Woodrow Wilson, and Eli Lilly himself, among many others.
In this highly original account, Stepan sheds new light on the role of science in reformulating issues of race, gender, reproduction, and public health in an era when the focus on national identity was particularly intense. Drawing upon a rich body of evidence concerning the technical publications and professional meetings of Latin American eugenicists, she examines how they adapted eugenic principles to local contexts between the world wars. Stepan shows that Latin American eugenicists diverged considerably from their counterparts in Europe and the United States in their ideological approach and their interpretations of key texts concerning heredity.
These are the words of Roberto Escobar-the top accountant for the notorious and deadly Medell?n Cartel, and brother of Pablo Escobar, the most famous drug lord in history. At the height of his reign, Pablo's multibillion-dollar operation smuggled tons of cocaine each week into countries all over the world. Roberto and his ten accountants kept track of all the money. Only Pablo and Roberto knew where it was stashed-and what it bought.
And the amounts of money were simply staggering. According to Roberto, it cost $2,500 every month just to purchase the rubber bands needed to wrap the stacks of cash. The biggest problem was finding a place to store it: from secret compartments in walls and beneath swimming pools to banks and warehouses everywhere. There was so much money that Roberto would sometimes write off ten percent as "spoilage," meaning either rats had chewed up the bills or dampness had ruined the cash.
Roberto writes about the incredible violence of the cartel, but he also writes of the humanitarian side of his brother. Pablo built entire towns, gave away thousands of houses, paid people's medical expenses, and built schools and hospitals. Yet he was responsible for the horrible deaths of thousands of people.
In short, this is the story of a world of riches almost beyond mortal imagination, and in his own words, Roberto Escobar tells all: building a magnificent zoo at Pablo's opulent home, the brothers' many escapes into the jungles of Colombia, devising ingenious methods to smuggle tons of cocaine into the United States, bribing officials with literally millions of dollars-and building a personal army to protect the Escobar family against an array of enemies sworn to kill them.
Few men in history have been more beloved-or despised-than Pablo Escobar. Now, for the first time, his story is told by the man who knew him best: his brother, Roberto.
Rosen, writing in the 1950s, may have had good reason to believe that infectious diseases would soon be conquered. But as Dr. Pascal James Imperato writes in the new foreword to this edition, infectious disease remains a grave threat. Globalization, antibiotic resistance, and the emergence of new pathogens and the reemergence of old ones, have returned public health efforts to the basics: preventing and controlling chronic and communicable diseases and shoring up public health infrastructures that provide potable water, sewage disposal, sanitary environments, and safe food and drug supplies to populations around the globe.
A revised introduction by Elizabeth Fee frames the book within the context of the historiography of public health past, present, and future, and an updated bibliography by Edward T. Morman includes significant books on public health history published between 1958 and 2014. For seasoned professionals as well as students, A History of Public Health is visionary and essential reading.
What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world.
In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future. Through exclusive interviews and original archival research, Max explains this story’s connection to human greed and ambition–from the Prussian chemist Justus von Liebig, who made cattle meatier by feeding them the flesh of other cows, to New Guinean natives whose custom of eating the brains of the dead nearly wiped them out. The biologists who have investigated these afflictions are just as extraordinary–for example, Daniel Carleton Gajdusek, a self-described “pedagogic pedophiliac pediatrician” who cracked kuru and won the Nobel Prize, and another Nobel winner, Stanley Prusiner, a driven, feared self-promoter who identified the key protein that revolutionized prion study.
With remarkable precision, grace, and sympathy, Max–who himself suffers from an inherited neurological illness–explores maladies that have tormented humanity for centuries and gives reason to hope that someday cures will be found. And he eloquently demonstrates that in our relationship to nature and these ailments, we have been our own worst enemy.
Several themes explored in the book illustrate ways in which non-medical factors influence our views of a disease and our reaction to it. One of these themes is the tendency to focus blame for the spread of a disease on a particular group (e.g., women, blacks, sinners). The balance between protecting the rights of individuals and protecting the public health, in issues such as whether to quarantine the infected and whether to require mandatory testing for the disease, is another theme. A third theme is the persistent reluctance of many Americans to discuss venereal disease openly because it involves sex, a subject that we are often not comfortable talking about.
Did you know...
- Medical interventions have become the third leading cause of death in America.
- An estimated 10 percent of Americans are implanted with medical devices -- like pacemakers, artificial hips, cardiac stents, etc.
- The overwhelming majority of high-risk implanted devices have never undergone a single clinical trial.
In THE DANGER WITHIN US, award-winning journalist Jeanne Lenzer brings these horrifying statistics to life through the story of one working class man who, after his "cure" nearly kills him, ends up in a battle for justice against the medical establishment.
His crusade leads Lenzer on a journey through the dark underbelly of the medical device industry, a fascinating and disturbing world that hasn't been written about before. What Lenzer exposes will shock readers: rampant corruption, elaborate cover-ups, shameless profiteering, and astonishing lack of oversight, all of which leads to dangerous devices (from artificial hips to pacemakers) going to market and into our bodies.
In the vein of America's Bitter Pill and A Civil Action, THE DANGER WITHIN US is a stirring call for reform and a must-read for anyone who cares about the future of American healthcare. span
PKU (phenylketonuria) is a genetic disorder that causes severe cognitive impairment if it is not detected and treated with a strict and difficult diet. Programs to detect PKU and start treatment early are deservedly considered a public health success story. Some have traded on this success to urge expanded newborn screening, defend basic research in genetics, and confront proponents of genetic determinism. In this context, treatment for PKU is typically represented as a simple matter of adhering to a low-phenylalanine diet. In reality, the challenges of living with PKU are daunting.
In this first general history of PKU, a historian and a pediatrician explore how a rare genetic disease became the object of an unprecedented system for routine testing. The PKU Paradox is informed by interviews with scientists, clinicians, policymakers, and individuals who live with the disease. The questions it raises touch on ongoing controversies about newborn screening and what happens to blood samples collected at birth. -- M. Susan Lindee, University of Pennsylvania
In the summer of 1623, ten cardinals and hundreds of their attendants, engaged in electing a new Pope, died from the 'mal'aria' or 'bad air' of the Roman marshes. Their choice, Pope Urban VIII, determined that a cure should be found for the fever that was the scourge of the Mediterranean, northern Europe and America, and in 1631 a young Jesuit apothecarist in Peru sent to the Old World a cure that had been found in the New – where the disease was unknown.
The cure was quinine, an alkaloid made of the bitter red bark of the cinchona tree, which grows in the Andes. Both disease and cure have an extraordinary history. Malaria badly weakened the Roman Empire. It killed thousands of British troops fighting Napoleon during the Walcheren raid on Holland in 1809 and many soldiers on both sides of the American Civil War. It turned back many of the travellers who explored west Africa and brought the building of the Panama Canal to a standstill. When, after a thousand years, a cure was finally found, Europe's Protestants, among them Oliver Cromwell, who suffered badly from malaria, feared it was nothing more than a Popish poison. More than any previous medicine, though, quinine forced physicians to change their ideas about treating illness. Before long, it would change the face of Western medicine.
Using fresh research from the Vatican and the Indian Archives in Seville, as well as hitherto undiscovered documents in Peru, Fiammetta Rocco describes the ravages of the disease, the quest of the three Englishmen who smuggled cinchona seeds out of South America, the way quinine opened the door to Western imperial adventure in Asia, Africa and beyond, and why, even today, quinine grown in the eastern Congo still saves so many people suffering from malaria.
Note that it has not been possible to include the same picture content that appeared in the original print version.
Eric Schmidt is one of Silicon Valley’s great leaders, having taken Google from a small startup to one of the world’s most influential companies. Jared Cohen is the director of Google Ideas and a former adviser to secretaries of state Condoleezza Rice and Hillary Clinton. With their combined knowledge and experiences, the authors are uniquely positioned to take on some of the toughest questions about our future: Who will be more powerful in the future, the citizen or the state? Will technology make terrorism easier or harder to carry out? What is the relationship between privacy and security, and how much will we have to give up to be part of the new digital age?
In this groundbreaking book, Schmidt and Cohen combine observation and insight to outline the promise and peril awaiting us in the coming decades. At once pragmatic and inspirational, this is a forward-thinking account of where our world is headed and what this means for people, states and businesses.
With the confidence and clarity of visionaries, Schmidt and Cohen illustrate just how much we have to look forward to—and beware of—as the greatest information and technology revolution in human history continues to evolve. On individual, community and state levels, across every geographical and socioeconomic spectrum, they reveal the dramatic developments—good and bad—that will transform both our everyday lives and our understanding of self and society, as technology advances and our virtual identities become more and more fundamentally real.
As Schmidt and Cohen’s nuanced vision of the near future unfolds, an urban professional takes his driverless car to work, attends meetings via hologram and dispenses housekeeping robots by voice; a Congolese fisherwoman uses her smart phone to monitor market demand and coordinate sales (saving on costly refrigeration and preventing overfishing); the potential arises for “virtual statehood” and “Internet asylum” to liberate political dissidents and oppressed minorities, but also for tech-savvy autocracies (and perhaps democracies) to exploit their citizens’ mobile devices for ever more ubiquitous surveillance. Along the way, we meet a cadre of international figures—including Julian Assange—who explain their own visions of our technology-saturated future.
Inspiring, provocative and absorbing, The New Digital Age is a brilliant analysis of how our hyper-connected world will soon look, from two of our most prescient and informed public thinkers.
Updated with a new preface and an epilogue analyzing developments since the early 1980s, this new edition of The Social Transformation of American Medicine is a must-read for anyone concerned about the future of our fraught healthcare system.
With The Structure of Scientific Revolutions, Kuhn challenged long-standing linear notions of scientific progress, arguing that transformative ideas don’t arise from the day-to-day, gradual process of experimentation and data accumulation but that the revolutions in science, those breakthrough moments that disrupt accepted thinking and offer unanticipated ideas, occur outside of “normal science,” as he called it. Though Kuhn was writing when physics ruled the sciences, his ideas on how scientific revolutions bring order to the anomalies that amass over time in research experiments are still instructive in our biotech age.
This new edition of Kuhn’s essential work in the history of science includes an insightful introduction by Ian Hacking, which clarifies terms popularized by Kuhn, including paradigm and incommensurability, and applies Kuhn’s ideas to the science of today. Usefully keyed to the separate sections of the book, Hacking’s introduction provides important background information as well as a contemporary context. Newly designed, with an expanded index, this edition will be eagerly welcomed by the next generation of readers seeking to understand the history of our perspectives on science.
Winner of the PEN/E.O. Wilson Literary Science Writing Award • Los Angeles Times Book Prize Winner
NAMED ONE OF THE BEST BOOKS OF THE YEAR BY
The Washington Post • New York Post • NPR • The Economist • New York • Wired • Kirkus Reviews • BookPage
In 1953, a twenty-seven-year-old factory worker named Henry Molaison—who suffered from severe epilepsy—received a radical new version of the then-common lobotomy, targeting the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry was left profoundly amnesic, unable to create long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.
Patient H.M. is, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.
Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons, as they called themselves, conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world.
Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.
“An exciting, artful blend of family and medical history.”—The New York Times
*Kirkus Reviews (starred review)
Soldiers on both sides frequently complained about the annoying pests that fed on their blood, buzzed in their ears, invaded their tents, and generally contributed to the misery of army life. Little did they suspect that the South's large mosquito population operated as a sort of mercenary force, a third army, one that could work for or against either side depending on the circumstances. Malaria and yellow fever not only sickened thousands of Union and Confederate soldiers but also affected the timing and success of certain key military operations. Some commanders took seriously the threat posed by the southern disease environment and planned accordingly; others reacted only after large numbers of their men had already fallen ill. African American soldiers were ordered into areas deemed unhealthy for whites, and Confederate quartermasters watched helplessly as yellow fever plagued important port cities, disrupting critical supply chains and creating public panics.
Bell also chronicles the effects of disease on the civilian population, describing how shortages of malarial medicine helped erode traditional gender roles by turning genteel southern women into smugglers. Southern urbanites learned the value of sanitation during the Union occupation only to endure the horror of new yellow fever outbreaks once it ended, and federal soldiers reintroduced malaria into non-immune northern areas after the war. Throughout his lively narrative, Bell reinterprets familiar Civil War battles and events from an epidemiological standpoint, providing a fascinating medical perspective on the war.
By focusing on two specific diseases rather than a broad array of Civil War medical topics, Bell offers a clear understanding of how environmental factors serve as agents of change in history. Indeed, with Mosquito Soldiers, he proves that the course of the Civil War would have been far different had mosquito-borne illness not been part of the South's landscape in the 1860s.
In Influenza, George Dehner examines the wide disparity in national and international responses to influenza pandemics, from the Russian flu of 1889 to the swine flu outbreak in 2009. He chronicles the technological and institutional progress made along the way and shows how these developments can shape an effective future policy.
Early pandemic response relied on methods of quarantine and individual scientific research. In the aftermath of World War II, a consensus for cooperation and shared resources led to the creation of the WHO, under the auspices of the United Nations. Today, the WHO maintains a large and proactive role in responding to influenza outbreaks. International pandemic response, however, is only as strong as its weakest national link--most recently evidenced in the failed early detection of the 2009 swine flu in Mexico and the delayed reporting of the 2002 SARS outbreak in China.
As Dehner's study contends, the hard lessons of the past highlight the need for a coordinated early warning system with full disclosure, shared technologies, and robust manufacturing capabilities. Until the "national" aspect can be removed from the international equation, responses will be hampered, and a threat to an individual remains a threat to all.
Anxiety is rooted in an ancient part of the brain, and our ability to be anxious is inherited from species far more ancient than humans. Anxiety is often adaptive: it enables us to respond to threats. But when normal fear yields to what psychiatry categorizes as anxiety disorders, it becomes maladaptive. As Horwitz explores the history and multiple identities of anxiety—melancholia, nerves, neuroses, phobias, and so on—it becomes clear that every age has had its own anxieties and that culture plays a role in shaping how anxiety is expressed.-- Peter Conrad, Brandeis University
Dr. Forrester tells the story of these rebels and the risks they took with their own lives and the lives of others to heal the most elemental of human organs - the heart. The result is a compelling chronicle of a disease and its cure, a disease that is still with us, but one that is slowly being worn away by "The Heart Healers".
Little more than one hundred years ago, maps of the world still boasted white space: places where no human had ever trod. Within a few short decades the most hostile of the world’s environments had all been conquered. Likewise, in the twentieth century, medicine transformed human life. Doctors took what was routinely fatal and made it survivable. As modernity brought us ever more into different kinds of extremis, doctors pushed the bounds of medical advances and human endurance. Extreme exploration challenged the body in ways that only the vanguard of science could answer. Doctors, scientists, and explorers all share a defining trait: they push on in the face of grim odds. Because of their extreme exploration we not only understand our physiology better; we have also made enormous strides in the science of healing.
Drawing on his own experience as an anesthesiologist, intensive care expert, and NASA adviser, Dr. Kevin Fong examines how cuttingedge medicine pushes the envelope of human survival by studying the human body’s response when tested by physical extremes. Extreme Medicine explores different limits of endurance and the lens each offers on one of the systems of the body. The challenges of Arctic exploration created opportunities for breakthroughs in open heart surgery; battlefield doctors pioneered techniques for skin grafts, heart surgery, and trauma care; underwater and outer space exploration have revolutionized our understanding of breathing, gravity, and much more. Avant-garde medicine is fundamentally changing our ideas about the nature of life and death.
Through astonishing accounts of extraordinary events and pioneering medicine, Fong illustrates the sheer audacity of medical practice at extreme limits, where human life is balanced on a knife’s edge. Extreme Medicine is a gripping debut about the science of healing, but also about exploration in its broadest sense—and about how, by probing the very limits of our biology, we may ultimately return with a better appreciation of how our bodies work, of what life is, and what it means to be human.
David Herzberg addresses these questions by tracing the rise of psychiatric medicines, from Miltown in the 1950s to Valium in the 1970s to Prozac in the 1990s. The result is more than a story of doctors and patients. From bare-knuckled marketing campaigns to political activism by feminists and antidrug warriors, the fate of psychopharmacology has been intimately wrapped up in the broader currents of modern American history. Beginning with the emergence of a medical marketplace for psychoactive drugs in the postwar consumer culture, Herzberg traces how "happy pills" became embroiled in Cold War gender battles and the explosive politics of the "war against drugs"—and how feminists brought the two issues together in a dramatic campaign against Valium addiction in the 1970s. A final look at antidepressants shows that even the Prozac phenomenon owed as much to commerce and culture as to scientific wizardry.
With a barrage of "ask your doctor about" advertisements competing for attention with shocking news of drug company malfeasance, Happy Pills is an invaluable look at how the commercialization of medicine has transformed American culture since the end of World War II.-- Lizabeth Cohen, author of A Consumers' Republic: The Politics of Mass Consumption in Postwar America
Pioneer Doctor: The Story of a Woman's Work is the true story of Dr. Mary (Mollie) Babcock Atwater, a medicine woman who found freedom and opportunity in the wide-open spaces of America's frontier west. This remarkable tale has been creatively retold here by her granddaughter, award-winning author Mari Grana. Blending information from historical records as well as interviews with family and friends, the author has reconstructed Mollie's steps into a dramatic narrative that brings to life the doctor's struggles, her accomplishments, and the times in which she lived.
Beautifully written and thoroughly researched, this is not just the biography of a fascinating woman. It is also the story of an era when daring women ventured forth and changed history for the rest of us.
Ferngren first describes how early Christians understood disease. He examines the relationship of early Christian medicine to the natural and supernatural modes of healing found in the Bible. Despite biblical accounts of demonic possession and miraculous healing, Ferngren argues that early Christians generally accepted naturalistic assumptions about disease and cared for the sick with medical knowledge gleaned from the Greeks and Romans.
Ferngren also explores the origins of medical philanthropy in the early Christian church. Rather than viewing illness as punishment for sins, early Christians believed that the sick deserved both medical assistance and compassion. Even as they were being persecuted, Christians cared for the sick within and outside of their community. Their long experience in medical charity led to the creation of the first hospitals, a singular Christian contribution to health care.
This book cuts through Money’s talent for polemic and self-promotion by digging into the substance of Money’s theories and achievements. It offers, for the first time, a balanced and probing textual analysis of this pioneering scholar’s writing to assess Money’s profound impact on the debates and research on sexuality and gender that dominated the last half of the twentieth century. Through his analysis, Goldie recovers Money’s brilliance and insight from simplistic dismissals of his work due to his involvement in the tragic David Reimer case, while never losing sight of his flaws.
During the post–World War II "wonder drug" revolution, antibiotics were viewed as a panacea for mastering infectious disease. But from the beginning, critics raised concerns about irrational usage and overprescription. The first generation of antibiotic reformers focused on regulating the drug industry. The reforms they set in motion included the adoption of controlled clinical trials as the ultimate arbiters of therapeutic efficacy, the passage of the Kefauver-Harris amendments mandating proof of drug efficacy via well-controlled studies, and the empowering of the Food and Drug Administration to remove inefficacious drugs from the market. Despite such victories, no entity was empowered to rein in physicians who inappropriately prescribed, or overly prescribed, approved drugs.
Now, in an era of emerging bugs and receding drugs, discussions of antibiotic resistance focus on the need to develop novel antibiotics and the need for more appropriate prescription practices in the face of pharmaceutical marketing, pressure from patients, and the structural constraints that impede rational delivery of antibiotics worldwide. Concerns about the enduring utility of antibiotics—indeed, about a post-antibiotic era—are widespread, as evidenced by reports from the Centers for Disease Control and Prevention, academia, and popular media alike. Only by understanding the historical forces that have shaped our current situation, Podolsky argues, can we properly understand and frame our choices moving forward.-- John E. Lesch, University of California