Volume 39 of Advances in Genetics completes the trilogy of volumes authored by Dr. Igor Zhimulev of the Institute of Cytology and Genetics in Novosibirsk, Russia. This set comprises what is perhaps the most comprehensive collection of volumes dedicated to the study of polytene chromosomes. Volume 39 picks up where the previous two volumes, 34 and 37, left off. It covers the organization of genetic material in the morphological structures of the interphase chromosome, the chromomeres and the interchromomeric regions, and the structural changes occurring during the activation of the chomomeres, the puffs.
The field of genetics is rapidly evolving and new medical breakthroughs are occurring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.
This volume of Advances in Genetics continues the series goal to present both human and molecular genetic reviews in a timely fashion. Anderson and Kay investigate CAB gene expression in the regulation of gene transcriptions in plants. Harmon and Allan offer a historical overview of apoptosis and its recent heightened interest. Developments involving four X-linked disorders and their resulting increased susceptibility to infection are presented by Smithand Notarangelo. Dickson and colleagues present research on the role of dystrophin in Duchenne muscular dystrophy and the potential feasibility of gene therapy in curing this disease as well as other diseases involving the heart and central nervous system. The relationship between mice and humans and the ways in which they help each other understand gene function and relationship is presented by Elizabeth Fisher. Timmons and Shearn summarize what information has been learned about prune, Killer of prune, and the prune/Killer of prune lethal interactions: rare genetic phenomena in Drosophila melanogaster. Meiotic recombination, via the breaking and rejoining of DNA and the subsequent reciprocal exchange and the cytological evidence of the exchange, are explored by Ross et al. Last, Coonar and McKenna discuss the four major cardiomyopathies, focusing on recent advances in hypertrophic cardiomyopathy.
In this volume, Petes and Pukkila synthesize the latest research on meiotic recombination, with specific reference to crossover and gene conversions. The "absurd size and complex" structure of the Dystrophin gene is considered in another chapter, with discussions of strategies for future diagnosis and treatment of muscular dystrophy. Two chapters also examine the molecular genetics of sex determination, including the influence of maternal age and resulting chromosomal aberrations. Volume 33 also includes a review of the PAX and HOX gene families and their links to the developmental process, cellular growth control, and forms of cancer. Case studies of thrombophilia, Menkes, and Wilson diseases are used to exemplify the genetic disorders of blood clotting, copper deficiency, and toxicity, respectively. Triman takes a genetic approach to understanding the function of ribosomal RNA using E. coli as the model best able to reveal the inherent complications of the translation process. Leach and O'Connell describe the use of radiation hybrids for constructing high-resolution maps of the human genome. With these reviews the alliance of Molecular Genetic Medicine with Advances in Genetics is completed under the banner of Advances in Genetics.
* Presents technical and historical overviews of molecular biology applied to disease detection, diagnosis, and treatment
* Chronicles the continuing explosion of knowledge in molecular genetic medicine by highlighting current approaches to understanding human illness
* Documents the revolution in human and molecular genetics leading to a new field of medicine
* This volume highlights Analysis of human chromosomes with chapters on pathology of sex determination and numerical chromosomal abnormalities Molecular and genetic bases of muscular dystrophy and Menkes and Wilson diseases Techniques including FISH, IRS-PCR, and radiation hybrids
Expression patterns of regulatory genes and the role they play in development
Hereditary ataxias and specific disease states where the genetic defect has been identified
Minute genes, their mutations, and their molecular function in Drosophila
The genetics and molecular biology of rhythm mutants and clock molecules
Double strand breaks in DNA and their repair mechanismsExpression patterns of regulatory genes and the role they play in developmentHereditary ataxias and specific disease states where the genetic defect has been identifiedMinute genes, their mutations, and their molecular function in DrosophilaThe genetics and molecular biology of rhythm mutants and clock moleculesDouble-strand breaks in DNA and their repair mechanisms and lack of repair mechanisms resulting in human disorders
In the Foreword to Volume 32, Drs. Friedmann and Giannelli suggest: "Progress toward a thorough characterization of the human genome is stunningly rapid and exceeding many of its earliest expectations. Disease-related genes will be falling from the skies faster than we can understand them, and mechanisms responsible for the pathogenesis of disease will be illuminated more quickly and readily than ever before. "With comprehensive and timely reviews, Advances in Genetics incorporating Molecular Genetic Medicine offers with every volume further insight into this expanding field of medicine, supplementing the continued expert coverage of all other areas of genetics pioneered by Advances in Genetics.
* Presents technical and historical overviews of molecular biology applied to disease detection, diagnosis, and treatment
* Chronicles the continuing explosion of knowledge in molecular genetic medicine by highlighting current approaches to understanding human illness
* Documents the revolution in human and molecular genetics leading to a new field of medicine
* Volume 32 marks new collaboration with Associate Editors Dr. Theodore Friedmann and Dr. Francesco Giannelli
The Future of the Mind brings a topic that once belonged solely to the province of science fiction into a startling new reality. This scientific tour de force unveils the astonishing research being done in top laboratories around the world—all based on the latest advancements in neuroscience and physics—including recent experiments in telepathy, mind control, avatars, telekinesis, and recording memories and dreams. The Future of the Mind is an extraordinary, mind-boggling exploration of the frontiers of neuroscience. Dr. Kaku looks toward the day when we may achieve the ability to upload the human brain to a computer, neuron for neuron; project thoughts and emotions around the world on a brain-net; take a “smart pill” to enhance cognition; send our consciousness across the universe; and push the very limits of immortality.
An instant bestseller that is poised to become a classic, Moonwalking with Einstein recounts Joshua Foer's yearlong quest to improve his memory under the tutelage of top "mental athletes." He draws on cutting-edge research, a surprising cultural history of remembering, and venerable tricks of the mentalist's trade to transform our understanding of human memory. From the United States Memory Championship to deep within the author's own mind, this is an electrifying work of journalism that reminds us that, in every way that matters, we are the sum of our memories.
From the Trade Paperback edition.
Ray Kurzweil is arguably today’s most influential—and often controversial—futurist. In How to Create a Mind, Kurzweil presents a provocative exploration of the most important project in human-machine civilization—reverse engineering the brain to understand precisely how it works and using that knowledge to create even more intelligent machines.
Kurzweil discusses how the brain functions, how the mind emerges from the brain, and the implications of vastly increasing the powers of our intelligence in addressing the world’s problems. He thoughtfully examines emotional and moral intelligence and the origins of consciousness and envisions the radical possibilities of our merging with the intelligent technology we are creating.
Certain to be one of the most widely discussed and debated science books of the year, How to Create a Mind is sure to take its place alongside Kurzweil’s previous classics which include Fantastic Voyage: Live Long Enough to Live Forever and The Age of Spiritual Machines.
From the Hardcover edition.
Jeff Hawkins, the man who created the PalmPilot, Treo smart phone, and other handheld devices, has reshaped our relationship to computers. Now he stands ready to revolutionize both neuroscience and computing in one stroke, with a new understanding of intelligence itself.
Hawkins develops a powerful theory of how the human brain works, explaining why computers are not intelligent and how, based on this new theory, we can finally build intelligent machines.
The brain is not a computer, but a memory system that stores experiences in a way that reflects the true structure of the world, remembering sequences of events and their nested relationships and making predictions based on those memories. It is this memory-prediction system that forms the basis of intelligence, perception, creativity, and even consciousness.
In an engaging style that will captivate audiences from the merely curious to the professional scientist, Hawkins shows how a clear understanding of how the brain works will make it possible for us to build intelligent machines, in silicon, that will exceed our human ability in surprising ways.
Written with acclaimed science writer Sandra Blakeslee, On Intelligence promises to completely transfigure the possibilities of the technology age. It is a landmark book in its scope and clarity.
On December 10, 1996, Jill Bolte Taylor, a thirty-seven- year-old Harvard-trained brain scientist experienced a massive stroke in the left hemisphere of her brain. As she observed her mind deteriorate to the point that she could not walk, talk, read, write, or recall any of her life-all within four hours-Taylor alternated between the euphoria of the intuitive and kinesthetic right brain, in which she felt a sense of complete well-being and peace, and the logical, sequential left brain, which recognized she was having a stroke and enabled her to seek help before she was completely lost. It would take her eight years to fully recover.
For Taylor, her stroke was a blessing and a revelation. It taught her that by "stepping to the right" of our left brains, we can uncover feelings of well-being that are often sidelined by "brain chatter." Reaching wide audiences through her talk at the Technology, Entertainment, Design (TED) conference and her appearance on Oprah's online Soul Series, Taylor provides a valuable recovery guide for those touched by brain injury and an inspiring testimony that inner peace is accessible to anyone.
When Temple Grandin was born in 1947, autism had only just been named. Today it is more prevalent than ever, with one in 88 children diagnosed on the spectrum. And our thinking about it has undergone a transformation in her lifetime: Autism studies have moved from the realm of psychology to neurology and genetics, and there is far more hope today than ever before thanks to groundbreaking new research into causes and treatments. Now Temple Grandin reports from the forefront of autism science, bringing her singular perspective to a thrilling journey into the heart of the autism revolution.
Weaving her own experience with remarkable new discoveries, Grandin introduces the neuroimaging advances and genetic research that link brain science to behavior, even sharing her own brain scan to show us which anomalies might explain common symptoms. We meet the scientists and self-advocates who are exploring innovative theories of what causes autism and how we can diagnose and best treat it. Grandin also highlights long-ignored sensory problems and the transformative effects we can have by treating autism symptom by symptom, rather than with an umbrella diagnosis. Most exciting, she argues that raising and educating kids on the spectrum isn’t just a matter of focusing on their weaknesses; in the science that reveals their long-overlooked strengths she shows us new ways to foster their unique contributions.
From the “aspies” in Silicon Valley to the five-year-old without language, Grandin understands the true meaning of the word spectrum. The Autistic Brain is essential reading from the most respected and beloved voices in the field.
In contrast to the “baseline brain” that fulfills the tasks of everyday life, Chopra and Tanzi propose that, through a person’s increased self-awareness and conscious intention, the brain can be taught to reach far beyond its present limitations. “We are living in a golden age for brain research, but is this a golden age for your brain?” they ask.
Super Brain explains how it can be, by combining cutting-edge research and spiritual insights, demolishing the five most widespread myths about the brain that limit your potential, and then showing you methods to:
-Use your brain instead of letting it use you
-Create the ideal lifestyle for a healthy brain
-Reduce the risks of aging
-Promote happiness and well-being through the mind-body connection
-Access the enlightened brain, the gateway to freedom and bliss
-Overcome the most common challenges, such as memory loss, depression, anxiety, and obesity
Your brain is capable of incredible healing and constant reshaping. Through a new relationship with your brain you can transform your life. In Super Brain, Chopra and Tanzi guide you on a fascinating journey that envisions a leap in human evolution. The brain is not just the greatest gift that Nature has given us. It’s the gateway to an unlimited future that you can begin to live today.
Growing up in the high desert of California, Jim Doty was poor, with an alcoholic father and a mother chronically depressed and paralyzed by a stroke. Today he is the director of the Center for Compassion and Altruism Research and Education (CCARE) at Stanford University, of which the Dalai Lama is a founding benefactor. But back then his life was at a dead end until at twelve he wandered into a magic shop looking for a plastic thumb. Instead he met Ruth, a woman who taught him a series of exercises to ease his own suffering and manifest his greatest desires. Her final mandate was that he keep his heart open and teach these techniques to others. She gave him his first glimpse of the unique relationship between the brain and the heart.
Doty would go on to put Ruth’s practices to work with extraordinary results—power and wealth that he could only imagine as a twelve-year-old, riding his orange Sting-Ray bike. But he neglects Ruth’s most important lesson, to keep his heart open, with disastrous results—until he has the opportunity to make a spectacular charitable contribution that will virtually ruin him. Part memoir, part science, part inspiration, and part practical instruction, Into the Magic Shop shows us how we can fundamentally change our lives by first changing our brains and our hearts.
Hallucinations don’t belong wholly to the insane. Much more commonly, they are linked to sensory deprivation, intoxication, illness, or injury. People with migraines may see shimmering arcs of light or tiny, Lilliputian figures of animals and people. People with failing eyesight, paradoxically, may become immersed in a hallucinatory visual world. Hallucinations can be brought on by a simple fever or even the act of waking or falling asleep, when people have visions ranging from luminous blobs of color to beautifully detailed faces or terrifying ogres. Those who are bereaved may receive comforting “visits” from the departed. In some conditions, hallucinations can lead to religious epiphanies or even the feeling of leaving one’s own body.
Humans have always sought such life-changing visions, and for thousands of years have used hallucinogenic compounds to achieve them. As a young doctor in California in the 1960s, Oliver Sacks had both a personal and a professional interest in psychedelics. These, along with his early migraine experiences, launched a lifelong investigation into the varieties of hallucinatory experience.
Here, with his usual elegance, curiosity, and compassion, Dr. Sacks weaves together stories of his patients and of his own mind-altering experiences to illuminate what hallucinations tell us about the organization and structure of our brains, how they have influenced every culture’s folklore and art, and why the potential for hallucination is present in us all, a vital part of the human condition.
Shortlisted for both the Guardian First Book Prize and the Costa Book Award
Longlisted for the Samuel Johnson Prize for Non-Fiction
A Finalist for the Pol Roger Duff Cooper Prize
A Finalist for the Wellcome Book Prize
A Financial Times Best Book of the Year
An Economist Best Book of the Year
A Washington Post Notable Book of the Year
What is it like to be a brain surgeon? How does it feel to hold someone's life in your hands, to cut into the stuff that creates thought, feeling, and reason? How do you live with the consequences of performing a potentially lifesaving operation when it all goes wrong?
In neurosurgery, more than in any other branch of medicine, the doctor's oath to "do no harm" holds a bitter irony. Operations on the brain carry grave risks. Every day, leading neurosurgeon Henry Marsh must make agonizing decisions, often in the face of great urgency and uncertainty.
If you believe that brain surgery is a precise and exquisite craft, practiced by calm and detached doctors, this gripping, brutally honest account will make you think again. With astonishing compassion and candor, Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets, and the moments of black humor that characterize a brain surgeon's life.
Do No Harm provides unforgettable insight into the countless human dramas that take place in a busy modern hospital. Above all, it is a lesson in the need for hope when faced with life's most difficult decisions.
With fifteen practical, easy-to-implement solutions involving nutritious foods, natural supplements and vitamins, positive-thinking habits, and, when necessary, highly targeted medications, Dr. Amen shows you how to:
* Reach and maintain your ideal weight
* Soothe and smooth your skin at any age
* Reduce the stress that can impair your immune system
* Sharpen your memory
* Increase willpower and eliminate the cravings that keep you from achieving your exercise and diet goals
* Enhance sexual desire and performance
* Lower your blood pressure without medication
* Avoid depression and elevate the enjoyment you take in life’s pleasures.
Based on the latest medical research, as well as on Dr. Amen’s two decades of clinical practice at the renowned Amen Clinics, where Dr. Amen and his associates pioneered the use of the most advanced brain imaging technology, Change Your Brain, Change Your Body shows you how to take the very best care of your brain.
Whether you’re just coming to realize that it’s time to get your body into shape, or are already fit and want to take it to the next level, Change Your Brain, Change Your Body is all you need to start putting the power of the brain-body connection to work for you today.
From the Hardcover edition.
Horowitz introduces the reader to dogs’ perceptual and cognitive abilities and then draws a picture of what it might be like to be a dog. What’s it like to be able to smell not just every bit of open food in the house but also to smell sadness in humans, or even the passage of time? How does a tiny dog manage to play successfully with a Great Dane? What is it like to hear the bodily vibrations of insects or the hum of a fluorescent light? Why must a person on a bicycle be chased? What’s it like to use your mouth as a hand? In short, what is it like for a dog to experience life from two feet off the ground, amidst the smells of the sidewalk, gazing at our ankles or knees?
Inside of a Dog explains these things and much more. The answers can be surprising—once we set aside our natural inclination to anthropomorphize dogs. Inside of a Dog also contains up-to-the-minute research—on dogs’ detection of disease, the secrets of their tails, and their skill at reading our attention—that Horowitz puts into useful context. Although not a formal training guide, Inside of a Dog has practical application for dog lovers interested in understanding why their dogs do what they do. With a light touch and the weight of science behind her, Alexandra Horowitz examines the animal we think we know best but may actually understand the least. This book is as close as you can get to knowing about dogs without being a dog yourself.
Whether eating, taking drugs, engaging in sex, or doing good deeds, the pursuit of pleasure is a central drive of the human animal. In The Compass of Pleasure Johns Hopkins neuroscientist David J. Linden explains how pleasure affects us at the most fundamental level: in our brain.
As he did in his award-winning book, The Accidental Mind, Linden combines cutting-edge science with entertaining anecdotes to illuminate the source of the behaviors that can lead us to ecstasy but that can easily become compulsive. Why are drugs like nicotine and heroin addictive while LSD is not? Why has the search for safe appetite suppressants been such a disappointment? The Compass of Pleasure concludes with a provocative consideration of pleasure in the future, when it may be possible to activate our pleasure circuits at will and in entirely novel patterns.
Why do some innocent kids grow up to become cold-blooded serial killers? Is bad biology partly to blame? For more than three decades Adrian Raine has been researching the biological roots of violence and establishing neurocriminology, a new field that applies neuroscience techniques to investigate the causes and cures of crime. In The Anatomy of Violence, Raine dissects the criminal mind with a fascinating, readable, and far-reaching scientific journey into the body of evidence that reveals the brain to be a key culprit in crime causation.
Raine documents from genetic research that the seeds of sin are sown early in life, giving rise to abnormal physiological functioning that cultivates crime. Drawing on classical case studies of well-known killers in history—including Richard Speck, Ted Kaczynski, and Henry Lee Lucas—Raine illustrates how impairments to brain areas controlling our ability to experience fear, make good decisions, and feel guilt predispose us to violence. He contends that killers can actually be coldhearted: something as simple as a low resting heart rate can give rise to violence. But arguing that biology is not destiny, he also sketches out provocative new biosocial treatment approaches that can change the brain and prevent violence.
Finally, Raine tackles the thorny legal and ethical dilemmas posed by his research, visualizing a futuristic brave new world where our increasing ability to identify violent offenders early in life might shape crime-prevention policies, for good and bad. Will we sacrifice our notions of privacy and civil rights to identify children as potential killers in the hopes of helping both offenders and victims? How should we punish individuals with little to no control over their violent behavior? And should parenting require a license? The Anatomy of Violence offers a revolutionary appraisal of our understanding of criminal offending, while also raising provocative questions that challenge our core human values of free will, responsibility, and punishment.
From the Hardcover edition.
Early studies of the human brain used a simple method: wait for misfortune to strike -- strokes, seizures, infectious diseases, horrendous accidents -- and see how victims coped. In many cases their survival was miraculous, if puzzling. Observers were amazed by the transformations that took place when different parts of the brain were destroyed, altering victims' personalities. Parents suddenly couldn't recognize their own children. Pillars of the community became pathological liars. Some people couldn't speak but could still sing.
In The Tale of the Dueling Neurosurgeons, Sam Kean travels through time with stories of neurological curiosities: phantom limbs, Siamese twin brains, viruses that eat patients' memories, blind people who see through their tongues. He weaves these narratives together with prose that makes the pages fly by, to create a story of discovery that reaches back to the 1500s and the high-profile jousting accident that inspired this book's title.* With the lucid, masterful explanations and razor-sharp wit his fans have come to expect, Kean explores the brain's secret passageways and recounts the forgotten tales of the ordinary people whose struggles, resilience, and deep humanity made neuroscience possible.
*"The Tale of the Dueling Neurosurgeons" refers to the case of French king Henri II, who in 1559 was lanced through the skull during a joust, resulting in one of the most significant cases in neuroscience history. For hundreds of years scientists have gained important lessons from traumatic accidents and illnesses, and such misfortunes still represent their greatest resource for discovery.
A General Theory of Love demonstrates that our nervous systems are not self-contained: from earliest childhood, our brains actually link with those of the people close to us, in a silent rhythm that alters the very structure of our brains, establishes life-long emotional patterns, and makes us, in large part, who we are. Explaining how relationships function, how parents shape their child’s developing self, how psychotherapy really works, and how our society dangerously flouts essential emotional laws, this is a work of rare passion and eloquence that will forever change the way you think about human intimacy.
From the Trade Paperback edition.
Why are we drawn to the ocean each summer? Why does being near water set our minds and bodies at ease? In BLUE MIND, Wallace J. Nichols revolutionizes how we think about these questions, revealing the remarkable truth about the benefits of being in, on, under, or simply near water. Combining cutting-edge neuroscience with compelling personal stories from top athletes, leading scientists, military veterans, and gifted artists, he shows how proximity to water can improve performance, increase calm, diminish anxiety, and increase professional success.
BLUE MIND not only illustrates the crucial importance of our connection to water-it provides a paradigm shifting "blueprint" for a better life on this Blue Marble we call home.
Forty-four percent of Americans will go through a major faith transition in their lives. And now, with church attendance on the decline and increasing cultural independence from Christian social norms, this trend has reached a tipping point: the fastest growing religion in America is "none."
Mike McHargue understands the pain of unraveling belief. In Finding God in the Waves, Mike tells the story of how his Evangelical faith dissolved into atheism as he studied the Bible, a crisis that threatened his identity, his friendships, and even his marriage. Years later, Mike was standing on the shores of the Pacific Ocean when a bewildering, seemingly mystical moment motivated him to take another look. But this time, it wasn't theology or scripture that led him back to God—it was science.
Full of insights about the universe, as well as deeply personal reflections on our desire for certainty and meaning, Finding God in the Waves is a vital exploration of the possibility for knowing God in an age of reason, and a signpost for where the practice of faith is headed in a secular age. Among other revelations, we learn what brain scans reveal about what happens when we pray; how fundamentalism affects the psyche; and how God is revealed not only in scripture, but in the night sky, in subatomic particles, and in us.
From the Hardcover edition.
Research into the human brain has exploded in recent years, and neuroscience has become a major program at many universities and a required course for a wide range of studies. Neuroscience For Dummies tracks to an introductory neuroscience class, giving you an understanding of the brain's structure and function, as well as a look into the relationship between memory, learning, emotions, and the brain. Providing insight into the biology of mental illness and a glimpse at future treatments and applications of neuroscience, Neuroscience For Dummies is a fascinating read for students and general interest readers alike.
The brain holds the secrets to our personalities, our use of language, our love of music, and our memories. Neuroscience For Dummies looks at how this complex structure works, according to the most recent scientific discoveries, illustrated by helpful diagrams and engaging anecdotes.Helpful diagrams and engaging anecdotes enhance material The latest scientific discoveries are sprinkled throughout Tracks to a typical introductory neuroscience class
From how the brain works to how you feel emotions, Neuroscience For Dummies offers a comprehensive overview of the fascinating study of the human brain.
Anarchy Evolution is a provocative look at the collision between religion and science, by an author with unique authority: UCLA lecturer in Paleontology, and founding member of Bad Religion, Greg Graffin. Alongside science writer Steve Olson (whose Mapping Human History was a National Book Award finalist) Graffin delivers a powerful discussion sure to strike a chord with readers of Richard Dawkins’ The God Delusion or Christopher Hitchens God Is Not Great. Bad Religion die-hards, newer fans won over during the band’s 30th Anniversary Tour, and anyone interested in this increasingly important debate should check out this treatise on science from the god of punk rock.
Incomplete Nature begins by accepting what other theories try to deny: that, although mental contents do indeed lack these material-energetic properties, they are still entirely products of physical processes and have an unprecedented kind of causal power that is unlike anything that physics and chemistry alone have so far explained. Paradoxically, it is the intrinsic incompleteness of these semiotic and teleological phenomena that is the source of their unique form of physical influence in the world. Incomplete Nature meticulously traces the emergence of this special causal capacity from simple thermodynamics to self-organizing dynamics to living and mental dynamics, and it demonstrates how specific absences (or constraints) play the critical causal role in the organization of physical processes that generate these properties.
The book's radically challenging conclusion is that we are made of these specific absenses—such stuff as dreams are made on—and that what is not immediately present can be as physically potent as that which is. It offers a figure/background shift that shows how even meanings and values can be understood as legitimate components of the physical world.
NAMED ONE OF THE BEST BOOKS OF THE YEAR BY THE WASHINGTON POST
Imagine spending the first forty years of your life in darkness, blind to the emotions and social signals of other people. Then imagine that someone suddenly switches the lights on.
It has long been assumed that people living with autism are born with the diminished ability to read the emotions of others, even as they feel emotion deeply. But what if we’ve been wrong all this time? What if that “missing” emotional insight was there all along, locked away and inaccessible in the mind?
In 2007 John Elder Robison wrote the international bestseller Look Me in the Eye, a memoir about growing up with Asperger’s syndrome. Amid the blaze of publicity that followed, he received a unique invitation: Would John like to take part in a study led by one of the world’s foremost neuroscientists, who would use an experimental new brain therapy known as TMS, or transcranial magnetic stimulation, in an effort to understand and then address the issues at the heart of autism? Switched On is the extraordinary story of what happened next.
Having spent forty years as a social outcast, misreading others’ emotions or missing them completely, John is suddenly able to sense a powerful range of feelings in other people. However, this newfound insight brings unforeseen problems and serious questions. As the emotional ground shifts beneath his feet, John struggles with the very real possibility that choosing to diminish his disability might also mean sacrificing his unique gifts and even some of his closest relationships. Switched On is a real-life Flowers for Algernon, a fascinating and intimate window into what it means to be neurologically different, and what happens when the world as you know it is upended overnight.
Praise for Switched On
“An eye-opening book with a radical message . . . The transformations [Robison] undergoes throughout the book are astonishing—as foreign and overwhelming as if he woke up one morning with the visual range of a bee or the auditory prowess of a bat.”—The New York Times
“Astonishing, brave . . . reads like a medical thriller and keeps you wondering what will happen next . . . [Robison] takes readers for a ride through the thorny thickets of neuroscience and leaves us wanting more.”—The Washington Post
“Fascinating for its insights into Asperger’s and research, this engrossing record will make readers reexamine their preconceptions about this syndrome and the future of brain manipulation.”—Booklist
“Like books by Andrew Solomon and Oliver Sacks, Switched On offers an opportunity to consider mental processes through a combination of powerful narrative and informative medical context.”—BookPage
“A mind-blowing book that will force you to ask deep questions about what is important in life. Would normalizing the brains of those who think differently reduce their motivation for great achievement?”—Temple Grandin, author of The Autistic Brain
“At the heart of Switched On are fundamental questions of who we are, of where our identity resides, of difference and disability and free will, which are brought into sharp focus by Robison’s lived experience.”—Graeme Simsion, author of The Rosie Effect
Berit Brogaard, PhD, and Kristian Marlow, MA, study people with astonishing talents—memory champions, human echolocators, musical virtuosos, math geniuses, and synesthetes who taste colors and hear faces. But as amazing as these abilities are, they are not mysterious. Our brains constantly process a huge amount of information below our awareness, and what these gifted individuals have in common is that through practice, injury, an innate brain disorder, or even more unusual circumstances, they have managed to gain a degree of conscious access to this potent processing power.
The Superhuman Mind takes us inside the lives and brains of geniuses, savants, virtuosos, and a wide variety of ordinary people who have acquired truly extraordinary talents, one way or another. Delving into the neurological underpinnings of these abilities, the authors even reveal how we can acquire some of them ourselves—from perfect pitch and lightning fast math skills to supercharged creativity.
The Superhuman Mind is a book full of the fascinating science readers look for from the likes of Oliver Sacks, combined with the exhilarating promise of Moonwalking with Einstein.
When Cathy Davidson and Duke University gave free iPods to the freshman class in 2003, critics said they were wasting their money. Yet when students in practically every discipline invented academic uses for their music players, suddenly the idea could be seen in a new light-as an innovative way to turn learning on its head.
This radical experiment is at the heart of Davidson's inspiring new book. Using cutting-edge research on the brain, she shows how "attention blindness" has produced one of our society's greatest challenges: while we've all acknowledged the great changes of the digital age, most of us still toil in schools and workplaces designed for the last century. Davidson introduces us to visionaries whose groundbreaking ideas-from schools with curriculums built around video games to companies that train workers using virtual environments-will open the doors to new ways of working and learning. A lively hybrid of Thomas Friedman and Norman Doidge, Now You See It is a refreshingly optimistic argument for a bold embrace of our connected, collaborative future.
This is the story of how your life shapes your brain, and how your brain shapes your life.
(A companion to the six-part PBS series. Color illustrations throughout.)
Addiction is costly on many levels to the individuals affected, their families and society as a whole, but science may soon be able to offer treatment options to make the road to recovery a little smoother. In this eBook, From Abuse to Recovery: Understanding Addiction, we tackle the many facets of this complex issue. First, we investigate why and how people succumb to a veritable prison of the mind as Sections 1 and 2 delve respectively into the psychology and the neurochemistry behind addiction. In "Time-Warping Temptations," David Freedman posits how "temporal discounting" can lead us to give into immediate impulse gratification rather than consider the long-term consequences. Later, two articles by Eric Nestler, "The Addicted Brain" and "Hidden Switches in the Mind," break down how both reward and pleasure circuits become overactive and sensitized to our drug of choice. Subsequent sections break out addictive substances individually: recreational drugs, prescription drugs, alcohol and nicotine. In "Bad Combo," Melinda Wenner Moyer looks at the death of Whitney Houston, who overdosed in February 2010 on a deadly mixture of alcohol and prescription drugs. "Alcoholism and Our Genes" by John Nurnberger, Jr. and Laura Jean Beirut is a lengthy story exploring genetic association studies. Since smoking is one of the hardest habits to break, another article, "Hooked from the First Cigarette," by Joseph DiFranza discusses exactly why this is the case. Finally, Section 7 examines new avenues for overcoming addiction. Michelle Solis's piece, "A Lifeline for Addicts" describes addiction as an impairment in reversal learning and a consequence of rigid synapses – an impairment that studies show could potentially be treated, thus making the recovery process easier. While rehab centers, counseling and 12-step programs are effective for many substance abusers, they're also ingrained as the only way to overcome addiction. New research such as this advances our knowledge of the physical component, knowledge that could lead to a more complete protocol that treats both the psychological and physiological aspects of addiction.
At the heart of this book is an elegant elucidation of the pivotal contribution of reductionism to modern art’s extraordinary evolution and to its role in a monumental shift in artistic perspective. Reductionism was a driving force in the transition from figurative art to the first explorations of abstract art in the works of Turner, Monet, Kandinsky, Schoenberg, and Mondrian. Kandel explains how the New York School of Pollock, de Kooning, Rothko, Louis, Turrell, and Flavin arrived at their particular forms of abstract expressionism in the postwar era, and concludes with Katz, Warhol, Close, and Sandback, who built upon the advances of the New York School to reimagine figurative and minimal art. Featuring captivating drawings of the brain alongside full-color reproductions of modern art masterpieces, this book brings science and art into closer relation.
Stephen Macknik and Susana Martinez-Conde, the founders of the exciting new discipline of neuromagic, have convinced some of the world's greatest magicians to allow scientists to study their techniques for tricking the brain. This book is the result of the authors' yearlong, world-wide exploration of magic and how its principles apply to our behavior. Magic tricks fool us because humans have hardwired processes of attention and awareness that are hackable—a good magician uses your mind's own intrinsic properties against you in a form of mental jujitsu.
Now magic can reveal how our brains work in everyday situations. For instance, if you've ever bought an expensive item you'd sworn you'd never buy, the salesperson was probably a master at creating the "illusion of choice," a core technique of magic. The implications of neuromagic go beyond illuminating our behavior; early research points to new approaches for everything from the diagnosis of autism to marketing techniques and education. Sleights of Mind makes neuroscience fun and accessible by unveiling the key connections between magic and the mind.
We all have a rage circuit we can’t fully control once it is engaged as R. Douglas Fields, PhD, reveals in this essential book for our time. The daily headlines are filled with examples of otherwise rational people with no history of violence or mental illness suddenly snapping in a domestic dispute, an altercation with police, or road rage attack. We all wish to believe that we are in control of our actions, but the fact is, in certain circumstances we are not. The sad truth is that the right trigger in the right circumstance can unleash a fit of rage in almost anyone.
But there is a twist: Essentially the same pathway in the brain that can result in a violent outburst can also enable us to act heroically and altruistically before our conscious brain knows what we are doing. Think of the stranger who dives into a frigid winter lake to save a drowning child.
Dr. Fields is an internationally recognized neurobiologist and authority on the brain and the cellular mechanisms of memory. He has spent years trying to understand the biological basis of rage and anomalous violence, and he has concluded that our culture’s understanding of the problem is based on an erroneous assumption: that rage attacks are the product of morally or mentally defective individuals, rather than a capacity that we all possess.
Fields shows that violent behavior is the result of the clash between our evolutionary hardwiring and triggers in our contemporary world. Our personal space is more crowded than ever, we get less sleep, and we just aren't as fit as our ancestors. We need to understand how the hardwiring works and how to recognize the nine triggers. With a totally new perspective, engaging narrative, and practical advice, Why We Snap uncovers the biological roots of the rage response and how we can protect ourselves—and others.
From the Hardcover edition.
This remarkable medical parallel launched Natterson-Horowitz on a journey of discovery that reshaped her entire approach to medicine. She began to search for other connections between the human and animal worlds: Do animals get breast cancer, anxiety-induced fainting spells, sexually transmitted diseases? Do they suffer from obsessive-compulsive disorder, bulimia, addiction?
The answers were astonishing. Dinosaurs suffered from brain cancer. Koalas catch chlamydia. Reindeer seek narcotic escape in hallucinogenic mushrooms. Stallions self-mutilate. Gorillas experience clinical depression.
Joining forces with science journalist Kathryn Bowers, Natterson-Horowitz employs fascinating case studies and meticulous scholarship to present a revelatory understanding of what animals can teach us about the human body and mind. “Zoobiquity” is the term the authors have coined to refer to a new, species-spanning approach to health. Delving into evolution, anthropology, sociology, biology, veterinary science, and zoology, they break down the walls between disciplines, redefining the boundaries of medicine.
Zoobiquity explores how animal and human commonality can be used to diagnose, treat, and heal patients of all species. Both authoritative and accessible, offering cutting-edge research through captivating narratives, this provocative book encourages us to see our essential connection to all living beings.
Our brains were designed for tribal life, for getting along with a select group of others (Us) and for fighting off everyone else (Them). But modern times have forced the world’s tribes into a shared space, resulting in epic clashes of values along with unprecedented opportunities. As the world shrinks, the moral lines that divide us become more salient and more puzzling. We fight over everything from tax codes to gay marriage to global warming, and we wonder where, if at all, we can find our common ground.
A grand synthesis of neuroscience, psychology, and philosophy, Moral Tribes reveals the underlying causes of modern conflict and lights the way forward. Greene compares the human brain to a dual-mode camera, with point-and-shoot automatic settings (“portrait,” “landscape”) as well as a manual mode. Our point-and-shoot settings are our emotions—efficient, automated programs honed by evolution, culture, and personal experience. The brain’s manual mode is its capacity for deliberate reasoning, which makes our thinking flexible. Point-and-shoot emotions make us social animals, turning Me into Us. But they also make us tribal animals, turning Us against Them. Our tribal emotions make us fight—sometimes with bombs, sometimes with words—often with life-and-death stakes.
A major achievement from a rising star in a new scientific field, Moral Tribes will refashion your deepest beliefs about how moral thinking works and how it can work better.
In Social, renowned psychologist Matthew Lieberman explores groundbreaking research in social neuroscience revealing that our need to connect with other people is even more fundamental, more basic, than our need for food or shelter. Because of this, our brain uses its spare time to learn about the social world--other people and our relation to them. It is believed that we must commit 10,000 hours to master a skill. According to Lieberman, each of us has spent 10,000 hours learning to make sense of people and groups by the time we are ten.
Social argues that our need to reach out to and connect with others is a primary driver behind our behavior. We believe that pain and pleasure alone guide our actions. Yet, new research using fMRI--including a great deal of original research conducted by Lieberman and his UCLA lab--shows that our brains react to social pain and pleasure in much the same way as they do to physical pain and pleasure. Fortunately, the brain has evolved sophisticated mechanisms for securing our place in the social world. We have a unique ability to read other people’s minds, to figure out their hopes, fears, and motivations, allowing us to effectively coordinate our lives with one another. And our most private sense of who we are is intimately linked to the important people and groups in our lives. This wiring often leads us to restrain our selfish impulses for the greater good. These mechanisms lead to behavior that might seem irrational, but is really just the result of our deep social wiring and necessary for our success as a species.
Based on the latest cutting edge research, the findings in Social have important real-world implications. Our schools and businesses, for example, attempt to minimalize social distractions. But this is exactly the wrong thing to do to encourage engagement and learning, and literally shuts down the social brain, leaving powerful neuro-cognitive resources untapped. The insights revealed in this pioneering book suggest ways to improve learning in schools, make the workplace more productive, and improve our overall well-being.
As development and subsequent habitat destruction accelerate, there are increasing pressures on wildlife populations. But there is an important and simple step toward reversing this alarming trend: Everyone with access to a patch of earth can make a significant contribution toward sustaining biodiversity. There is an unbreakable link between native plant species and native wildlife—native insects cannot, or will not, eat alien plants. When native plants disappear, the insects disappear, impoverishing the food source for birds and other animals. In many parts of the world, habitat destruction has been so extensive that local wildlife is in crisis and may be headed toward extinction.
Bringing Nature Home has sparked a national conversation about the link between healthy local ecosystems and human well-being, and the new paperback edition—with an expanded resource section and updated photos—will help broaden the movement. By acting on Douglas Tallamy's practical recommendations, everyone can make a difference.
This introductory text takes a unique thematic approach, guiding students along a clear path to understand the latest findings whether or not they have a background in neuroscience. It includes case studies and everyday examples designed to help students understand the more challenging aspects of the material. It is richly illustrated with carefully selected color graphics to enhance understanding. Enhanced pedagogy highlights key concepts for the student and aids in teaching. Chapter outlines, study questions, glossary, and image collection are also available on the student's companion website. Ancillary support saves instructors time and facilitates learning; test questions, image collection, and lecture slides are available on the instructor's manual website.
This book will be of interest to undergraduate students in Neuroscience, Psychology, and related disciplines that teach cognitive neuroscience.Provides a complete introduction to mind-brain science, written to be highly accessible to undergraduates with limited neuroscience trainingRichly illustrated with carefully selected color graphics to enhance understandingEnhanced pedagogy highlights key concepts for the student and aids in teaching - chapter outlines, study questions, glossary, and image collection are also available on student's companion websiteAncillary support saves instructors time and facilitates learning - test questions, image collection, and lecture slides available on instructor's manual website
Alzheimer's is a devastating and frightening disease, and as baby boomers age it's on the brink of becoming the great epidemic of the twenty-first century. Fortunately, by making proper lifestyle choices and avoiding certain risk factors, most people can prevent Alzheimer's, and it can be delayed in those who are genetically predisposed. The Anti- Alzheimer's Prescription presents a unique four-step program that includes menus, recipes, exercises, stress reduction techniques, and neurobics to lower the risk of Alzheimer's by as much as 70 percent.
Dr. Fortanasce, who witnessed his own father's painful decline from the disease, is determined to stop Alzheimer's from becoming pandemic.
Nearing forty, Dr. Wendy Suzuki was at the pinnacle of her career. An award-winning university professor and world-renowned neuroscientist, she had tenure, her own successful research lab, prestigious awards, and international renown.
That’s when to celebrate her birthday, she booked an adventure trip that forced her to wake up to a startling reality: despite her professional success, she was overweight, lonely, and tired and knew that her life had to change. Wendy started simply—by going to an exercise class. Eventually, she noticed an improvement in her memory, her energy levels, and her ability to work quickly and move from task to task easily. Not only did Wendy begin to get fit, but she also became sharper, had more energy, and her memory improved. Being a neuroscientist, she wanted to know why.
What she learned transformed her body and her life. Now, it can transform yours.
Wendy discovered that there is a biological connection between exercise, mindfulness, and action. With exercise, your body feels more alive and your brain actually performs better. Yes—you can make yourself smarter. In this fascinating book, Suzuki makes neuroscience easy to understand, interweaving her personal story with groundbreaking research, and offering practical, short exercises—4 minute Brain Hacks—to engage your mind and improve your memory, your ability to learn new skills, and function more efficiently.
Taking us on an amazing journey inside the brain as never before, Suzuki helps us unlock the keys to neuroplasticity that can change our brains, or bodies, and, ultimately, our lives.