In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group.
Key features include:
• Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups.
• How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism.
• Numerous examples and expanded discussions for complex concepts.
• Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice.
• An overview of structure activity relationships (SARs) and concepts that govern drug design.
• Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix.
Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry.
About the Authors
Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy.
Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.
NEW TO THIS EDITION:Three new chapters including new information on men’s health, women’s health, and pharmacogenomics and laboratory tests.Mini-cases embedded in each chapter provide therapy-related examples and reinforce important points made in the text.Quickview Charts give an overview of important clinical information including reference ranges and critical values.Learning Points focus on a clinical application of a major concept present in the chapter.
Government Is Us 2.0 picks up where the previous edition left off. It addresses the bigger questions that are being asked and discussed about the relationships among and between citizens and their governments, how individuals and agencies govern, and the institutional elements that keep us from engendering long-term, socially just participatory change.
The central argument of Government Is Us 2.0 is that much can be done to bridge the gulf between citizens and their governments. The chapter authors offer practical suggestions on how public administrators can productively involve citizens in government work, with steps that will increase citizens' trust in government through opportunities for direct connection and collaboration.
TechPrep™ contains more than 1,000 review questions to help readers prepare for national technician certification exams. A robust Practice Session feature allows users to create custom quizzes by setting topic area, time, and number of questions. The Simulated Exam function lets readers practice their test skills by providing a 90 question, 120 minute test, with questions weighted to mimic national certification exams. Students using TechPrep™ receive instant, automated scoring, and can quickly identify areas they’ve mastered, or practice subjects where they need improvement. Alone or with the new edition of the Manual for Pharmacy Technicians, 4th Edition andall-new Workbook for the Manual for Pharmacy Technicians, the Pharmacy Technician Review Guide and Practice Exam offers the most comprehensive review to help you achieve certification!
Although rotations are crucial to the development of skills needed to practice pharmacy, there has been little available to guide students in the best way to prepare and make the most of these experiences—until now.
Maximize Your Rotations: ASHP’s Student Guide to IPPEs, APPEs, and Beyond breaks down everything you need to know into easy-to-navigate chapters. Inside you will find the skills required to excel while on IPPE or APPE rotations, along with competencies that may be unique to one type of rotation or another.
Each chapter is written by an experienced preceptor, lending a valuable perspective.
By using this text, you will gain an appreciation of the general expectations and typical activities of each rotation experience before you begin. Better preparation means better performance. Maximize Your Rotations will also be a resource throughout the experiential year, offering everything from reminders of clinical issues and statistical reviews to advice on interviewing, CV writing, professional organizations, and more.
Maximize Your Rotations means less time getting up to speed—and more time getting ahead in your career. Your rotation experience can be the launching pad for your career, and there’s no better guide than Maximize Your Rotations.
Each chapter contains learning objectives, case studies, bibliographies, and charts that summarize the causes of high and low test results.
New for this edition: Updated and expanded Quick View tables in each chapter now match those in the popular quick-reference, Interpreting Laboratory Data: A Point-of-Care Guide New glossary of acronyms is right up front for a streamlined reference Normal value ranges of all tests have been standardized by an expert pathologist New and updated cases in each chapter apply your Basic Skills in clinical situations Reorganized to highlight the application of concepts by body system, and in special populationsBasic Skills in Interpreting Laboratory Data offers features that will help pharmacy students not only understand and engage with the material but also will streamline the transition from classroom to practice setting. After studying with this trusted text, students and pharmacists will more effectively monitor patient therapy, evaluate test results, and improve outcomes through optimal and focused pharmacotherapy.
From Abilify to Zyrtec and nearly every drug in between, Mosby's Drug Reference for Health Professions, 3rd Edition is the must-have item for every aspiring health professional. In fact, it's the only drug book on the market written specifically for health professionals! Filled with vital details your students need to know about patient medications, this updated edition features concise, reliable information that is easy to navigate and simple to follow. Key details are presented in short monographs for 1,000 generic drugs (including 4,500 trade-name drugs) that are listed alphabetically. Precautions and considerations sections are tailored to circumstances your students will face on the job. Make certain they have the most relevant information on hand for their studies and for clinical practice with Mosby's Drug Reference for Health Professions, 3rd Edition!
Decision making based on personal experience alone, without knowledge from well-designed, controlled, randomized trials with adequate sample size, often overestimates the efficacy and underestimates the safety risks associated with drugs. This book provides a roadmap that is instructional and, most importantly, practical for the pharmacist so these new skills can be applied immediately in practice.
Based on a five-step process perfected over ten years at the University of Missouri, Kansas City, School of Pharmacy, this exciting new approach will:
· Reduce complexity
· Shorten time for decision making support
· Maintain rigor
· Categorize quality of the evidence in a simple, straightforward, and logical manner
· Provide a process designed specifically for pharmacists making drug therapy decisions
Use of examples, tables, diagrams, and key points highlighted throughout the book and summarized at the end of each chapter provide the pharmacist with skills they can implement the next day to begin applying EBM principles to their practice.
Generic/trade names Route of administration Common dosage Side effects Auxiliary labelMedication Safety and Error Prevention chapter helps you confidently address growing concerns related to patient safety and prevent medication-related errors. Revised Math Calculations chapter incorporates helpful information to clarify complex pharmaceutical calculations. Updated content prepares you for the Pharmacy Technician Certification (PTC) exam and highlights current concerns you'll encounter in the workforce:
HIPAA regulationsThe Medicare Modernization Act Legal parameters for the sale of pseudoephedrine productsThe issuance of multiple Schedule II prescriptionsPending legislation requirements for Medicaid prescriptionsThe United States Pharmacopeia (USP) New full-color photographs familiarize you with current practice settings. Learning games and certification review quizzes on the companion Evolve website reinforce your understanding and challenge you to apply what you've learned.
If you are a patient, gain a better understanding of how a pharmacy functions; if you are a health care provider, learn how to better communicate with retail pharmacists. A Prescription for Retail Pharmacy provides helpful advice for those already working behind the counter, as well. Explore what is expected of pharmacy technicians and new techniques for pharmacists to use in handling the typical problems they encounter.
Whether your problems are in front of the counter or behind it, A Prescription for Retail Pharmacy provides the cure!
The book provides an overview of the function of the pharmaceutical microbiologist and what they need to know, from regulatory filing and GMP, to laboratory design and management, and compendia tests and risk assessment tools and techniques. These key aspects are discussed through a series of dedicated chapters, with topics covering auditing, validation, data analysis, bioburden, toxins, microbial identification, culture media, and contamination control.Contains the applications of pharmaceutical microbiology in sterile and non-sterile productsPresents the practical aspects of pharmaceutical microbiology testingProvides contamination control risks and remediation strategies, along with rapid microbiological methodsIncludes bioburden, endotoxin, and specific microbial risksHighlights relevant case studies and risk assessment scenarios
Mastering Pharmacy Technician Math: A Certification Review is a super-effective way for students preparing for the Pharmacy Technician Certification Board Examination to improve their ability to perform basic math and pharmacy-specific calculations. The book includes powerful learning aids such as practice exercises in each chapter, end-of-chapter Q&A, a 50-question pretest that reviews key concepts, and three 100-question practice tests to prepare you for the board exam. All questions are correlated to the learning outcomes found in the book so you know exactly what to review should you answer a question incorrectly.
Mastering Pharmacy Technician Math: A Certification Review is logically divided into ten chapters:
Chapter 1: Mathematical Concepts -- reviews the basic mathematical building blocks needed to master advanced pharmacy calculations, including fractions, decimals, percents, ratios, proportions, conversions, and cross-multiplication.
Chapter 2: Numbering Systems -- reviews the different systems of measurement and how to convert within and between them, including working with temperatures and time.
Chapter 3: Understanding Drugs and Drug Orders -- identifies drug strengths, doses, drug forms, and routes of administration and explains how to identify and interpret information on drug labels, package inserts, prescriptions, and medication orders.
Chapter 4: Methods of Dosage Calculations -- presents methods to perform dosage calculations correctly, including fraction proportion, ratio proportion, dimensional analysis, and formulas.
Chapter 5: Oral Dosages -- describes the processes for calculating dosages, amount to dispense, and estimated days' supply for oral medications.
Chapter 6: Parenteral Dosages (Excluding Intravenous) -- describes parenteral medications, including those given by injection; inhalants; transdermal, ophthalmic, and otic drugs; and drugs placed in the rectum or vagina.
Chapter 7: Intravenous Calculations -- describes how to calculate IV concentrations and how to prepare medications for continuous and intermittent IV infusion.
Chapter 8: Special Preparations Calculations -- describes the processes to calculate concentrations, ratio strengths, final volume/final strength, and dilutions, as well as how to write recipes to prepare compound drug orders and perform alligation calculations.
Chapter 9: Medication Safety and Calculations -- discusses pharmacokinetics, high-alert medications, look-alike/sound-alike medications, how to calculate drug half-life values, pediatric and geriatric calculations, DEA controlled substance requirements related to prescriber DEA numbers, and how to perform the calculation needed to verify DEA number validity.
Chapter 10: Business, Inventory, and Reimbursement Calculations -- discusses reimbursements and patient payments, and describes how to calculate overhead costs, profits and losses, markups, turnover rates, and correct costs and change.
This book offers a complete review of the basic mathematics concepts and skills, which provide a foundation for more advanced understanding of pharmacy-related topics. The guide provides students with the pharmacy basics necessary for correctly interpreting prescriptions and drug orders, and for performing dosing calculations that technicians face every day.
The chapters are broken down into four units and are organized to complement most pharmacy technician training curricula and to support the ASHP model curriculum:
· Review of Mathematics
· Systems of Measurement
· Preparing for Problem Solving in Pharmacy
· Dosing Calculations and Other Pharmacy Problems
Key features throughout the book include:
· Chapter objectives
· Key terms and definitions
· Examples of problem scenarios or calculations questions and solutions
· “Tech Note!” —provides a highlight of key points within the chapters
· “Numbers at Work” —illustrates why key concepts are important to know and skills are critical to master
· Practice problems
· A test bank
· Appendices that include the parts of a prescription, a glossary of terms, conversions, and abbreviations tables.
For additional resources related to this book, visit www.ashp.org/techcalculations.
For more than three decades, millions of consumers have trusted The Pill Book to provide official, FDA-approved information on more than 1,800 of the most commonly prescribed drugs in the United States with guidelines from leading pharmacists. Each drug is profiled in a concise, readable, easy-to-understand entry, making The Pill Book the perfect reference when you have questions about the medications your doctor prescribes. Inside you’ll discover
• generic and brand-name listings that can help you save money
• What each drug is for, and how it works
• usual dosages, and what to do if a dose is skipped
• side effects and possible adverse reactions, highlighted for quick reference
• interactions with other drugs and food
• overdose and addiction potential
• alcohol-free and sugar-free medications
• the most popular self-injected medications and their safe handling
• information for seniors, pregnant and breast-feeding women, children, and others with special needs
• cautions and warnings, and when to call your doctor
• 32 pages of actual-size color photographs of prescription pills*
No home should be without this book!
*Not all ereading devices will show the images in color and at the exact size.
Development and use of robust analytical methods is critical for the ability to generate accurate analytical data. Sample preparation is an integral part of the analytical method. In a survey conducted by LC-GC1, responses indicated that approximately two-thirds of the time spent testing and analyzing samples was spent on the sample preparation portion of the method. In addition, issues related to sample preparation accounted for one-third of the errors generated while performing an analytical method.
A number of challenges exist in the sample preparation/extraction of pharmaceutical dosage forms for potency and purity analysis as well as isolation and identification of impurities and degradants. These challenges increase for complex dosage forms such as some controlled release formulations and other challenging formulations such as suspensions, ointments, transdermal patches, etc. Challenges in developing rapid and rugged sample preparation methods include complete dispersion of the dosage form to facilitate extraction and solubilization of the analytes of interest, dealing with extracted interfering components and addressing drug-excipient interactions. A number of factors must be considered and addressed in each of these areas.
The objective of Sample Preparation of Pharmaceutical Dosage Forms is to provide an overview of the various sample preparation and extraction techniques available for pharmaceutical dosage forms. In addition to the review and discussion of specific techniques, sample preparation method development and trouble shooting strategies are discussed. Multiple examples and case studies are presented to highlight various potential issues and solutions.
Why medicines often fail to produce the desired result and how such failures can be avoided
How to think about drug product safety and effectiveness
How the main participants in a medications use system can improve outcomes and how professional and personal values, attitudes, and ethical reasoning fit into drug therapy
What a properly designed and managed medications use system would look like — specific components, how the components fit together into a system, and how the system can be maintained and improved
Ways to evaluate medications use systems, how to recognize ineffective systems operations, how to identify missing system components and how to correct them
How the environment of medications use affects systems operations and patient outcomes, and why standards must change to improve drug safety and effectiveness
Drug-related illnesses and complications cost the health care system billions of dollars each year. Medical errors account for approximately 100,000 deaths each year, and drugs are the most common cause of medical errors in hospitals. Synthesizing research studies from seven nations, Preventing Medication Errors and Improving Drug Therapy Outcomes: A Management Systems Approach explores medications use from a social perspective. It identifies and describes the preventable adverse outcomes of drug therapy, discusses the safety, cost-effectiveness, and quality of medications use from a management systems perspective, and proposes systematic solutions.
Now in its fourth edition, this best-selling textbook in pharmaceutics has been brought completely up to date to reflect the rapid advances in delivery methodologies by eye and injection, advances in drug formulations and delivery methods for special groups (such as children and the elderly), nanomedicine, and pharmacognosy. At the same time the editors have striven to maintain the accessibility of the text for students of pharmacy, preserving the balance between being a suitably pitched introductory text and a clear reflection of the state of the art.
New to this editionNew editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London. Twenty-two new contributors. Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals. Thoroughly revised and updated throughout. provides a logical, comprehensive account of drug design and manufactureincludes the science of formulation and drug deliverydesigned and written for newcomers to the design of dosage forms
New to this editionNew editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London. Twenty-two new contributors. Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals. Thoroughly revised and updated throughout.
The role of pharmacy technicians is rapidly expanding, and demand for well-trained technicians has never been higher! Technicians are assuming more responsibilities and are taking on greater leadership roles. Quality training material is increasingly important for new technicians entering the field, and current technicians looking to advance.
Look no further than the new 4th edition of the best-selling Manual for Pharmacy Technicians to master the practical skills and gain the foundational knowledge all technicians need to be successful.
NEW chapters cover the latest essentials:Specialty Pharmacy Practice Communication and Teamwork Billing and Reimbursement Durable and Nondurable Medical Equipment, Devices, and Supplies
NEW features include:Full color design, photos and illustrations enhance learning Rx for Success boxes share tips to help techs excel on the job Technology Topics highlight the latest in automation & technical areas Safety First features provide critical advice for enhancing safety & reducing errors Bolded key terms defined in chapter-level glossaries Streamlined contents divide book into 4 simple parts: introduction to pharmacy practice, foundation knowledge and skills, practice basics, and business applications Expanded self-assessment questions and calculations content
Alone or with the new edition of the Pharmacy Technician Certification Review and Practice Exam, the Manual for Pharmacy Technicians, 4th Edition offers pharmacy technicians the most relevant, authoritative, easy-to-use guide in the field.
Want more exercises and practice? Look for the NEW Workbook for the Manual for Pharmacy Technicians.
Fundamentals of Geriatric Pharmacotherapy, Second Edition gives practitioners the information they need to improve outcomes and personalize care for elderly patients. New to this edition are new chapters on “Palliative and Hospice Care” and “Infections and Antimicrobial Stewardship”. Additional enhancements in this edition include added links to new guidelines, assessment tools, and videos. Additional cases and a study guide will match the content map for certified geriatric pharmacists examination.
Useful features throughout the book guide practitioners in navigating the maze of information required when caring for the older patient. These include:
Summarized treatment guidelinesReviews of the evidence baseSpecial focus on recommendations for the frail elderlyFull case studies in each chapterClinical PearlsKey Points and Key Terms (with definitions) in each chapterThe demands of an aging population mean that a greater understanding of geriatric pharmacotherapy I now essential for all health care providers. Fundamentals of geriatric Pharmacotherapy, Second Edition ensures had the information to allow providers to respond appropriately
Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants.
This volume provides essential information for experienced development professionals but was also written to be useful for scientists just beginning work in the field and for others who need an understanding of long acting injections and implants. This book will also be ideal as a graduate textbook.
The present report, in contrast, offers a differentiated evaluation of the practice of homoeopathy in health care. It confirms homoeopathy as a valuable addition to the conventional medical landscape – a status it has been holding for a long time in practical health care.
The book has been conceived to fill the void in existing physician reference materials, and provides a comprehensive review of the theoretical knowledge and scope of pharmacotherapy in individuals who are hooked on a psychoactive substance.
While detailed scientific information is obtainable in other major articles, the book's straightforward format and style, along with its illustrations, will make for easy reading as emphasis is put on information specifically related to drugs that occur most abused in today’s society. The information provided is based on clinical practice rather than pure experimental data, which will give the physician more effective tools useful in their daily practice. Many mechanisms of action of abuse are described in detail and references are provided to direct the reader to further sources for additional information.
As a special feature, the book incorporates uncluttered tables and charts, which result in immediate clarification of the mode of action on the central nervous system and the reason for misuse, thus avoiding usual long and fatiguing text in common reference books. The book aims to give the reader a clear and concise plan on what to do when being faced with an overdose situation.
A well-organized Table of Contents rapidly leads the reader from general pharmacological issues to the specific overdose syndrome and its management. Additionally, significant emphasis is placed on the practical do's and don’ts for physicians, with special reference to the predictive signs of aberrant drug-related behavior and the identification of the drug diverter by using urine drug screening.
This accessible, real-world guide gets you ready for the practice of pharmacy, while giving you the proper training to be compliant with the law. To that end, the book expertly covers relevant laws, rules, and regulations, and it highlights the distinctions between state and federal law where appropriate. In no other reference can you find such a succinct, yet thorough, review of the full range of federal pharmacy laws, including the Controlled Substances Act; the Food, Drug, and Cosmetics Act; the new Dietary Supplement Health Education Act; the FDA Modernization Act; and the Medicare Modernization Act.
Features:Opening chapter on drug regulation and standards provides you with a practical legal framework for subsequent chapter material Overview of the drug approval process and federal reporting programs Chapter on internet sales and FDA authority to act Coverage of opioid addiction treatment and narcotic treatment programs Comprehensive set of 450+ MPJE(R)-format practice questions and answers A CD-ROM that reprises the practice questions to provide a board-simulating interface
Multiple Choice Questionswith answers have been included at the end of each chapter.
Conveniently listed alphabetically by generic drug name, each drug has its own face page featuring typical dosing ranges, alternative dosing adjustments by strata of renal function, specific dosing for dialysis and other dosing schemes.
This work will satisfy the dosing information needs of busy physicians involved in pharmacotherapy for patients with kidney disease, as well as pharmacists, nurses and students.
This user-friendly text is a compilation and commentary of selected federal laws and regulations pertaining to the general practice of pharmacy in the United States. It covers topics in a simple and concise format. Furthermore, case studies and review questions and a bulleted summary of key points make for easy reading and aid in comprehension.
Essentials of Pharmacy Law will be extremely useful to senior pharmacy students preparing for the Multi-State Jurisprudence Exam (NABLEX MJPE). as well as the voluntary Pharmacist Competency Exam offered to practicing pharmacists. It alsoalso serves as a valuable reference for pharmacy students, practicing pharmacists seeking licensure by reciprocity and/or preparing for the MJPE, pharmacy technicians who are in need of a comprehensive update, and other interested healthcare professionals.
The most up-to-date information about the more than 1,800 most commonly prescribed drugs in the United States:
• Generic and brand-name listings that can help you save money
• What the drug is for, and how it works
• Usual dosages, and what to do if a dose is skipped
• Side effects and possible adverse reactions, highlighted for quick reference
• Interactions with other drugs and food
• Overdose and addiction potential
• Alcohol-free and sugar-free medications
• The most popular self-injected medications and their safe handling
• Information for seniors, pregnant and breast-feeding women, children, and others with special needs
• Cautions and warnings, and when to call your doctor
• 32 pages of actual-size color photographs of prescription pills
From the Trade Paperback edition.
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1. Introduction to Medicinal Chemistry
3. Physicochemical Parameters
4. Drug Metabolism
6. General Anaesthetics
7. Local Anaesthetics
8. Sedative and Hypnotics
9. Central Nervous System
11. Antihistamines II
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This book of clinical pharmacology covers the science of drugs or pharmaceutical including their origin, composition, pharmacokinetics, mechanism of action, therapeutic use, side effects and toxicology with specific description of drugs followed by short headings makes it easy to understand and point-wise explanation of information. This clinical pharmacology book will be helpful for the medical students and practicing doctors.
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The Pharmacist's Guide to Antimicrobial Therapy and Stewardship puts all the necessary information in one place, including:
Evaluating potentially infected patientsIdentifying the infection's suspected source and related organismsComparing the range of anti-infectivesKnowing the factors that impact treatmentDeveloping an antimicrobial stewardship programA step-wise approach walks logically from overall key concepts to disease- and drug-specific information. Disease states are summarized for easy reference. Tables make it easy to evaluate recommended treatment options.
In infectious disease management, when answers are seldom black and white, this guide helps pharmacists make confident decisions.
DMSO is a natural chemical compound derived from trees as a by-product from paper manufacturing. DMSO has been called a new medical principle and a true wonder drug. It has proven effective, either by itself or in combination with other products in the treatment of nearly every ailment known.
There has been much controversy about DMSO over the last 50 years. It is one of the most studied medical products ever. Thousands of scientific articles have been written about DMSO. When used properly it is one of the safest products know. It is also very cheap to produce.
This book provides the documentation needed to show that DMSO is probably the most important product ever for the relief of human suffering.
******Archie is quite clearly a leading authorithy on DMSO. He has extensive knowledge and experience regarding the clinical benefits of DMSO treatment. For decades, Archie has studied and worked with DMSO. He understands the safety, utility and efficaciousness of DMSO. I highly recommend this book for anyone interested in health, especially for those who want to learn more about non toxic medical therapies. For individuals with certain health ailments, DMSO could prove quite benefical. -Daniel Junck, MD