This new edition has been thoroughly revised and updated and hasbeen redesigned to give the book a more contemporary look. As withprevious editions it contains numerous examples, references and aseries of exercises of increasing difficulty to encourage studentunderstanding. Updates include: Increased coverage of MALDI andESI, more detailed description of time of flight spectrometers, newmaterial on isotope ratio mass spectrometry, and an expanded rangeof applications.
Mass Spectrometry, Third Edition is an invaluableresource for all undergraduate and postgraduate students using thistechnique in departments of chemistry, biochemistry, medicine,pharmacology, agriculture, material science and food science. It isalso of interest for researchers looking for an overview of thelatest techniques and developments.
This book incorporates recent technological advances in analytical pyrolysis methods especially useful for the characterization of 163 typical synthetic polymers. The book briefly reviews the instrumentation available in advanced analytical pyrolysis, and offers guidance to perform effectually this technique combining with gas chromatography and mass spectrometry. Main contents are comprehensive sample pyrograms, thermograms, identification tables, and representative mass spectra (MS) of pyrolyzates for synthetic polymers. This edition also highlights thermally-assisted hydrolysis and methylation technique effectively applied to 33 basic condensation polymers.Coverage of Py-GC/MS data of conventional pyrograms and thermograms of basic 163 kinds of synthetic polymers together with MS and retention index data for pyrolyzates, enabling a quick identificationAdditional coverage of the pyrograms and their related data for 33 basic condensation polymers obtained by the thermally-assisted hydrolysis and methylation techniqueAll compiled data measured under the same experimental conditions for pyrolysis, gas chromatography and mass spectrometry to facilitate peak identificationSurveyable instant information on two facing pages dedicated to the whole data of a given polymer sample
Reviews of the First Edition
“For anyone wishing to know what really goes on in theirNMR experiments, I would highly recommend this book” –Chemistry World
“…I warmly recommend for budding NMRspectroscopists, or others who wish to deepen their understandingof elementary NMR theory or theoretical tools” –Magnetic Resonance in Chemistry
This book guides the reader through the mathematics, physics and practical techniques needed to use telescopes (from small amateur models to the larger instruments installed in many colleges) and to observe objects in the sky. Mathematics to around Advanced Placement standard (US) or A level (UK) is assumed, although High School Diploma (US) or GCSE-level (UK) mathematics plus some basic trigonometry will suffice most of the time. Most of the physics and engineering involved is described fully and requires no prior knowledge or experience.
This is a ‘how to’ book that provides the knowledge and background required to understand how and why telescopes work. Equipped with the techniques discussed in this book, the observer will be able to operate with confidence his or her telescope and to optimize its performance for a particular purpose. In principle the observer could calculate his or her own predictions of planetary positions (ephemerides), but more realistically the observer will be able to understand the published data lists properly instead of just treating them as ‘recipes.’ When the observer has obtained measurements, he/she will be able to analyze them in a scientific manner and to understand the significance and meaning of the results.
“Telescopes and Techniques, 3rd Edition” fills a niche at the start of an undergraduate astronomer’s university studies, as shown by it having been widely adopted as a set textbook. This third edition is now needed to update its material with the many new observing developments and study areas that have come into prominence since it was published. The book concentrates on the knowledge needed to understand how small(ish) optical telescopes function, their main designs and how to set them up, plus introducing the reader to the many ways in which objects in the sky change their positions and how they may be observed. Both visual and electronic imaging techniques are covered, together with an introduction to how data (measurements) should be processed and analyzed. A simple introduction to radio telescopes is also included. Brief coverage of the most advanced topics of photometry and spectroscopy are included, but mainly to enable the reader to see some of the developments possible from the basic observing techniques covered in the main parts of the book.
Organic Structures from Spectra, Fifth Edition is acarefully chosen set of more than 280 structural problems employingthe major modern spectroscopic techniques, a selection of 27problems using 2D-NMR spectroscopy, more than 20 problemsspecifically dealing with the interpretation of spin-spin couplingin proton NMR spectra and 8 problems based on the quantitativeanalysis of mixtures using proton and carbon NMRspectroscopy. All of the problems are graded to develop andconsolidate the student’s understanding of organicspectroscopy. The accompanying text is descriptive and onlyexplains the underlying theory at a level which is sufficient totackle the problems. The text includes condensed tables ofcharacteristic spectral properties covering the frequentlyencountered functional groups.
The examples themselves have been selected to include allimportant common structural features found in organic compounds andto emphasise connectivity arguments. Many of the compoundswere synthesised specifically for this purpose. There aremany more easy problems, to build confidence and demonstrate basicprinciples, than in other collections.
The fifth edition of this popular textbook:
• includes more than 250 new spectra and more than 25completely new problems;
• now incorporates an expanded suite of new problemsdealing with the analysis of 2D NMR spectra (COSY, C H Correlationspectroscopy, HMBC, NOESY and TOCSY);
• has been expanded and updated to reflect the newdevelopments in NMR and to retire older techniques that are nolonger in common use;
• provides a set of problems dealing specifically withthe quantitative analysis of mixtures using NMR spectroscopy;
• features proton NMR spectra obtained at 200, 400 and600 MHz and 13C NMR spectra include DEPT experiments as well asproton-coupled experiments;
• contains 6 problems in the style of the experimentalsection of a research paper and two examples of fully workedsolutions.
Organic Structures from Spectra, Fifth Edition will proveinvaluable for students of Chemistry, Pharmacy and Biochemistrytaking a first course in Organic Chemistry.
Nuclear Magnetic Resonance Spectroscopy
Reviews from earlier editions
“Your book is becoming one of the “go to”books for teaching structure determination here in theStates. Great work!”
“…I would definitely state that this book is themost useful aid to basic organic spectroscopy teaching in existenceand I would strongly recommend every instructor in this area to useit either as a source of examples or as a classtextbook”.
Magnetic Resonance in Chemistry
“Over the past year I have trained many students usingproblems in your book - they initially find it as a task. Butafter doing 3-4 problems with all their brains activities...working out the rest of the problems become a mania. They getaddicted to the problem solving and every time they solve a problemby themselves, their confident level also increases.”
“I am teaching the fundamentals of MolecularSpectroscopy and your books represent excellent sources ofspectroscopic problems for students.”
In the expanded second edition of Practical Guide and Spectral Atlas for Interpretive Near-Infrared Spectroscopy, the authors include new research, editorials, supplements, and molecular structural formulas, along with updated references and information on NIR spectra. The thoroughly updated and revised second edition offers a full library of color spectra in a larger format to ensure clarity and reader comprehension.
Providing a rich set of reference information required to interpret NIR spectra for research and industrial applications, this book:
Offers more than 300 figures representing all the major functional groups and their NIR frequency ranges Contains over 120 pages of tables and charts illustrating overlapping spectra Covers NIR spectra for organic compounds, including alkanes, carboxylic acids, amines, dienes, alkynes, heterocyclic compounds, amino acids, and aldehydes Provides comprehensive appendices with spectra-structure correlations, example spectra, and other useful data for interpreting NIR spectra
*Completely revised and updated throughout
*The definative guide for process engineers and designers
*Covers a complete range of basic day-to-day operation topics
The authors provide an introduction to the field of newcomers and a reference to those involved in the various aspects of industrial crystallization. It is a complete volume covering all aspects of industrial crystallization, including material related to both fundamentals and applications. This new edition presents detailed material on crystallization of biomolecules, precipitation, impurity-crystal interactions, solubility, and design.
Provides an ideal introduction for industrial crystallization newcomers
Serves as a worthwhile reference to anyone involved in the field
Covers all aspects of industrial crystallization in a single, complete volume
Compiling information from the available literature and supplementing gaps with private communications and personal observations and research, Chemical Analysis of Firearms, Ammunition, and Gunshot Residue summarizes the history of firearms and ammunition as it relates to the development of modern weapons. It details chemical aspects of forensic firearms casework with particular emphasis on the detection of gunshot residues (GSR) on a suspect’s skin and clothing surfaces.
Drawing on the extensive experience of the Northern Ireland Forensic Science Laboratory (NIFSL) which processed a large firearms caseload during the region’s recent violent past, this book records the statistics gathered and the scientific methods developed to meet the demands of law enforcement and courts of law. It describes the analysis and methodology developed to routinely examine samples from terrorist suspects for both firearms and explosives residues.
Providing crucial, hard-to-find data for forensic laboratories and forensic chemists with little or no prior knowledge of firearms, this seminal work presents a wide range of firearms chemistry information and outlines the creation of a statistical database to aid investigations.
Dr. James Smyth Wallace is a retired U.K. forensic scientist and a 25 year veteran of the Northern Ireland Forensic Science Laboratory. He is the author/co-author of 14 scientific papers, as well as a forensic science textbook. He is a member of the Forensic Science Society and retains an active interest in forensic chemistry, particularly in the area of trace evidence detection.
"...this is an excellent book which is both instructive and amusing to read. Its true value is neatly summarised in one of the closing sentences: 'We have supplied you with the guidelines and criteria which you can now apply when considering supercritical fluids for your own needs.'' - Chemistry in Britain, February 1995
* The first reference work on named reactions to present colored schemes for easier understanding
* 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples
* An opening list of abbreviations includes both structures and chemical names
* Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works
* Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools
* Extensive index quickly locates information using words found in text and drawings
The book assumes only a basic knowledge of complex numbers andmatrices, and provides the reader with numerous worked examples andexercises to encourage understanding. With the explicit aim ofcarefully developing the subject from the beginning, the textstarts with coverage of quarks and nucleons and progresses throughto a detailed explanation of several important NMR experiments,including NMR imaging, COSY, NOESY and TROSY.
Completely revised and updated, the Second Edition features newmaterial on the properties and distributions of isotopes, chemicalshift anisotropy and quadrupolar interactions, Pake patterns, spinechoes, slice selection in NMR imaging, and a complete new chapteron the NMR spectroscopy of quadrupolar nuclei. New appendices havebeen included on Euler angles, and coherence selection by fieldgradients. As in the first edition, all material is heavilysupported by graphics, much of which is new to thisedition.
Written for undergraduates and postgraduate students taking afirst course in NMR spectroscopy and for those needing anup-to-date account of the subject, this multi-disciplinary bookwill appeal to chemical, physical, material, life, medical, earthand environmental scientists. The detailed physical insights willalso make the book of interest for experienced spectroscopists andNMR researchers.
• An accessible and carefully written introduction,designed to help students to fully understand this complex anddynamic subject
• Takes a multi-disciplinary approach, focusing on basicprinciples and concepts rather than the more practical aspects
• Presents a strong pedagogical approach throughout, withemphasis placed on individual spins to aid understanding
• Includes numerous worked examples, problems, furtherreading and additional notes
Praise from the reviews of the First Edition:
"This is an excellent book... that many teachers of NMRspectroscopy will cherish... It deserves to be a‘classic’ among NMR spectroscopy texts." NMRIN BIOMEDICINE
"I strongly recommend this book to everyone…it isprobably the best modern comprehensive description of thesubject." ANGEWANDTE CHEMIE, INTERNATIONAL EDITION
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Students in the physical and life sciences, and in engineering, need to know about the physics and biology of light. Recently, it has become increasingly clear that an understanding of the quantum nature of light is essential, both for the latest imaging technologies and to advance our knowledge of fundamental life processes, such as photosynthesis and human vision. From Photon to Neuron provides undergraduates with an accessible introduction to the physics of light and offers a unified view of a broad range of optical and biological phenomena. Along the way, this richly illustrated textbook builds the necessary background in neuroscience, photochemistry, and other disciplines, with applications to optogenetics, superresolution microscopy, the single-photon response of individual photoreceptor cells, and more.
With its integrated approach, From Photon to Neuron can be used as the basis for interdisciplinary courses in physics, biophysics, sensory neuroscience, biophotonics, bioengineering, or nanotechnology. The goal is always for students to gain the fluency needed to derive every result for themselves, so the book includes a wealth of exercises, including many that guide students to create computer-based solutions. Supplementary online materials include real experimental data to use with the exercises.
Assumes familiarity with first-year undergraduate physics and the corresponding math
Overlaps the goals of the MCAT, which now includes data-based and statistical reasoning
Advanced chapters and sections also make the book suitable for graduate courses
An Instructor's Guide and illustration package is available to professors
The possible applications of enzymes are enormous. Years of development have seen many enzymes brought onto the market, but they are still expensive to use. Therefore, their efficient application is a prerequisite for common usage. One of the main factors for this efficiency is the stability of the enzymes. The topics thus ranged from the extensive fundamental thermodynamic knowledge gathered in academic research to the practical applied knowledge built up in industry during the time that enzymes have been produced commercially.
The subject Stability and Stabilization of Enzymes was discussed from various points of view, as was reflected in the themes of the symposium sessions. In the session on Fundamentals of Enzyme Stabilisation the thermodynamic background of the phenomenon was highlighted. In yet another session, the recently developed analytical tools to measure enzyme stability and stabilisation were discussed. Further sessions comprised the physical, chemical and biological ways to obtain enzyme stabilisation and finally, the industrial practice of enzyme stabilisation was treated by representatives of the world's most important enzyme producers. The book will be of interest to researchers in universities and industry in the fields of biochemistry, enzymology and biotechnology.
important for determining the 3D-structure of molecules.
This new edition of the popular classic has a clear style and a highly practical, mostly non-mathematical approach. Many examples are taken from organic and organometallic chemistry, making this book an invaluable guide to undergraduate and graduate students of organic chemistry, biochemistry, spectroscopy or physical chemistry, and to researchers using this well-established and extremely important technique. Problems and solutions are included.
In addition, readers get a close look at the hydrothermal synthesis of zeolites, fluorides, sulfides, tungstates, and molybdates, as well as native elements and simple oxides. Delving into the commercial production of various types, the authors clarify the effects of temperature, pressure, solvents, and various other chemical components on the hydrothermal processes.Gives an overview of the evolution of Hydrothermal Technology from geology to widespread industrial useDescribes the equipment used in the process and how it worksDiscusses problems involved with the growth of crystals, processing of technological materials, and environmental and safety issues
Dried blood spot (DBS) sampling involves the collection of asmall volume of blood, via a simple prick or other means, from astudy subject onto a cellulose or polymer paper card, which isfollowed by drying and transfer to the laboratory for analysis. Formany years, this method of blood sample collection has beenextensively utilized in some important areas of human healthcare(for example, newborn screening for inherited metabolic disordersand HIV-related epidemiological studies). Because of its advantagesover conventional blood, plasma, or serum sample collection, DBSsampling has been valued by the pharmaceutical industry in drugresearch and development.
Dried Blood Spots: Applications and Techniques featurescontributions from an international team of leading scientists inthe field. Their contributions present a unique resource on thehistory, principles, procedures, methodologies, applications, andemerging technologies related to DBS.
Presented in three parts, the book thoroughly examines:Applications of DBS sampling and associated procedures andmethodologies in various human healthcare studiesApplications and perspectives of DBS sampling in drug researchand development, and therapeutic drug monitoringNew technologies and emerging applications related to DBSsampling and analysis
Dried Blood Spots: Applications and Techniques is avaluable working guide for researchers, professionals, and studentsin healthcare, medical science, diagnostics, clinical chemistry,and pharmaceuticals, etc.
Compared to conventional Raman microscopy, coherent Raman scattering (CRS) allows label-free imaging of living cells and tissues at video rate by enhancing the weak Raman signal through nonlinear excitation. Edited by pioneers in the field and with contributions from a distinguished team of experts, Coherent Raman Scattering Microscopy explains how CRS can be used to obtain a point-by-point chemical map of live cells and tissues.
In color throughout, the book starts by establishing the foundation of CRS microscopy. It discusses the principles of nonlinear optical spectroscopy, particularly coherent Raman spectroscopy, and presents the theories of contrast mechanisms pertinent to CRS microscopy. The text then provides important technical aspects of CRS microscopy, including microscope construction, detection schemes, and data analyses. It concludes with a survey of applications that demonstrate how CRS microscopy has become a valuable tool in biomedicine.
Due to its label-free, noninvasive examinations of living cells and organisms, CRS microscopy has opened up exciting prospects in biology and medicine—from the mapping of 3D distributions of small drug molecules to identifying tumors in tissues. An in-depth exploration of the theories, technology, and applications, this book shows how CRS microscopy has impacted human health and will deepen our understanding of life processes in the future.
Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.
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Beginning with simple theoretical models and experimental techniques, the book develops the complete repertoire of theoretical principles and experimental techniques necessary for understanding and implementing the most sophisticated NMR experiments.
Important new techniques and applications of NMR spectroscopy have emerged since the first edition of this extremely successful book was published in 1996. This updated version includes new sections describing measurement and use of residual dipolar coupling constants for structure determination, TROSY and deuterium labeling for application to large macromolecules, and experimental techniques for characterizing conformational dynamics. In addition, the treatments of instrumentation and signal acquisition, field gradients, multidimensional spectroscopy, and structure calculation are updated and enhanced.
The book is written as a graduate-level textbook and will be of interest to biochemists, chemists, biophysicists, and structural biologists who utilize NMR spectroscopy or wish to understand the latest developments in this field.Provides an understanding of the theoretical principles important for biological NMR spectroscopyDemonstrates how to implement, optimize and troubleshoot modern multi-dimensional NMR experimentsAllows for the capability of designing effective experimental protocols for investigations of protein structures and dynamicsIncludes a comprehensive set of example NMR spectra of ubiquitin provides a reference for validation of experimental methods
This volume is comprised of 10 chapters and begins with a brief history of indicators, including the contribution of Robert Boyle in the field. The different kinds of indicators are also described, along with developments in indicators in the nineteenth century. The next chapter deals with the theory and principles of visual indicators, followed by a discussion on acid-base indicators such as organic dyes, inorganic substances, compounds capable of fluorescence, and chemiluminescent systems. Subsequent chapters explore other varieties of indicators, including indicators for non-aqueous acid-base titrations, metallochromic indicators, and adsorption indicators, as well as oxidation-reduction indicators and fluorescent and chemiluminescent indicators.
This book will be of interest to chemists.
Each chapter provides a discussion of the fundamental principles underlying the techniques, descriptions of the instrumentation, and numerous applications. The chapters also contain updated bibliographies and problems, and most have suggested experiments appropriate to the techniques. This completely revised and updated edition covers subjects in more detail, such as a completely revised x-ray chapter, expanded coverage of electroanalytical techniques, and expansion of chromatography and mass spectrometry topics to reflect the predominance of these instruments in laboratories. This includes state-of-the-art sample introduction and mass analyzers, and the latest developments in UPLC and hyphenated techniques. The book also contains new graphics and addresses several new topics:
Ion mobility spectrometry Time domain NMR (relaxometry) Electron spin resonance spectroscopy (ESR, EPR) Forensic science and bioanalytical applications Microcalorimetry and optical thermal instruments Laser-induced breakdown spectroscopy (LIBS)
This text uniquely combines instrumental analysis with organic spectral interpretation (IR, NMR, and MS). It provides detailed coverage of sampling, sample handling, sample storage, and sample preparation. In addition, the authors have included many instrument manufacturers’ websites, which contain extensive resources.
This comprehensive, textbook includes in-depth coverage of the major topics in forensic chemistry including: illicit drugs, fibers, fire and explosive residues, soils, glass and paints, the chemistry of fingerprint recovery on porous surfaces, the chemistry of firearms analysis, as well as two chapters on the key tools of forensic science, microscopy and chemometrics. Each topic is explored at an advanced college level, with an emphasis, throughout the text, on the use of chemical tools in evidence analysis.
Forensic Chemistry: Fundamentals and Applications is essential reading for advanced students of forensic science and analytical chemistry, as well as forensic science practitioners, researchers and faculty, and anyone who wants to learn about the fascinating subject of forensic chemistry in some depth.
This book is published as part of the AAFS series ‘Forensic Science in Focus’.
• Helps readers understand amorphous solid dispersionsand apply techniques to particular pharmaceutical systems
• Covers physical and chemical properties, screening,scale-up, formulation, drug product manufacture, intellectualproperty, and regulatory considerations
• Has an appendix with structure and propertyinformation for polymers commonly used in drug development and withmarketed drugs developed using the amorphous sold dispersionapproach
• Addresses global regulatory issues including USAregulations, ICH guidelines, and patent concerns around theworld
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