First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on hedgehog signaling.

Contributions from leading authoritiesInforms and updates on all the latest developments in the field

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on stem cell regulators.

Longest running series published by Academic Press Contributions by leading international authorities

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on activins and inhibins.

This textbook is specifically designed for upper-division undergraduate or graduate students in life science or pre-medical majors including dentistry or pharmacology, who are required to take a biochemistry or medical biochemistry course, but who are not necessarily biochemistry majors. The book adopts a unique approach to the topic compared with other biochemistry textbooks currently available, in that each biochemical subject is introduced by a human disease relating the biochemical principles to be developed in that chapter. The goal is to make biochemistry more meaningful to the student who is not normally shown the connection between biochemistry and medicine.

* Includes an abundance of figures
* Emphasizes human biochemistry
* Introduces each chapter with a relevant disease or clinical relationship

Anxiety, the latest volume in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on the roles that hormones and other factors play in anxiety and stress.

Each volume focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances, such as transmitters, cytokines, growth factors, and others thoroughly reviewed.

Provides cutting-edge reviews concerning the molecular and cellular biology of vitamins and hormonesContains expertise from world-renowned contributors Includes coverage of a vast array of subjects Presents in-depth, current information from the molecular to clinical level

Vitamin K, one of the group of fat-soluble vitamins (A, D, E and K), has come into prominence lately because its activity as a blood coagulation factor impinges on the widespread occurrence of deep vein thrombosis in the human population especially in the older age group. This volume focuses, not only on the problem of blood coagulation and hypercoagulability, but upon the individual status of vitamin K in the human.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists.

*Focuses on the problem of blood coagulation and hypercoagulability as well as bone metabolism and vascular biology
*In the category of basic science, contributions cover: VKOR1, the quinone reductases including structure, function and mechanism, vitamin K-dependent carboxylation, the actions of Gas6, vitamin K2-mediated apoptosis and other topics
*In the category of disease-related subjects, contributions cover warfarin therapy, diabetic nephropathy, bone health, including osteoporosis and tumor cell suppression, as well as other topics

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.Reviews on the most current topics in the fieldFertilization promoting peptide--a possible regulator of sperm function in vivoCytokines and pituitary hormone secretionMechanism of GnRH receptor signaling upon gonadotropin release and gene expression in pituitary gonadotrophsLuteinizing-hormone releasing hormone (LHRH) neuronsLH pulses and the corpus luteumGranulocyte colony-stimulating factor receptorThe physiological role of the melancortin receptorsThe growth hormone-releasing hormone receptor

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on anorexia.

Contributions from leading authoritiesInforms and updates on all the latest developments in the field

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on vitamin D hormone.

Expertise of the contributorsCoverage of a vast array of subjectsIn depth current information at the molecular to the clinical levels

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. Now, new discoveries have proved that several of the vitamins function as hormones and many of the substances inferred by the title of the serial function in signal transduction processes. Accordingly, the Editor-in-Chief has expanded the scope of the serial to reflect this newer understanding of function-structure relationships in cellular communication. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.

The discovery of TRAIL (TNF Related Apoptosis Inducing Ligand), also referred to as Apo-2, is in an era of intense research because TRAIL induces many cancer cells to undergo programmed cell death (apoptosis), while having no effect on normal cells. This important protein deserves extensive review at a formative time in the devlopement of our knowledge concerning its mechanism of action and the ways in which it can be used as a cancer chemotherapeutic agent. Consequently, this voume reviews the current status of research on TRAIL.

Selected Contents:
* Crystal Structure of RANK Ligand involved in bone metabolism
* Promoter of TRAIL-R2 Gene
* Monoclonal Antibodies against TRAIL
* Modulation of TRAIL signaling complex
* TRAIL in the airways
* FLIP Protein and TRAIL-Induced Apoptosis
* TRAIL and Ceramide
* TRAIL and Viral Infection
* TRAIL and Malignant Glioma

Biochemical Actions of Hormones, Volume XII is a compendium of papers discussing aspects of molecular biology with regard to hormone action and to certain hormone receptors. One paper discusses the different approaches and strategies that are used in determining the amino acid sequence. The paper also describes the structural organization of polyprotein precursors such as the peptide chemistry approach or the nucleic acid approach. Another paper investigates the regulation of prolactin biosynthesis by peptide hormones as a model for peptidergic regulation of gene expression. The paper defines in detail which components of the biosynthetic machinery are being regulated by the polypeptide hormones. One paper also analyzes the molecular biology of the metallothioneins, focusing on the glucocorticoid regulation of metallothioneins genes. Experiments show that when the mouse MT-I gene is activated in lymphoid cells, or transferred to other cells, it still retains information needed in metal-regulated expression, though glucocorticoids can no longer regulate the same gene. Other papers discuss the purification and properties of the nerve growth factor receptor, and the thyrotropin receptor. Micro-biologists, biochemists, molecular biologists, cellular biologists, endocrinologists, and scientists involved in cell research will find this collection valuable.

Biochemical Actions of Hormones, Volume X explores the important fields of recombinant DNA technology and nuclear matrix and their impact on biochemical endocrinology.
This volume is organized into 12 chapters and begins with a presentation of an excellent model for determining the role of various receptors operating at the genetic level using cells in culture derived from the anterior pituitary. These topics are followed by a summary of conceptual advances in understanding nerve growth factor and related hormones, as well as the polypeptide hormones, which are recognized as growth factors for cells in culture. A chapter provides some insights into the pineal hormone, melatonin. The remaining chapters discuss the Ah carcinogen receptor, which seems to be analogous in many respects to a steroid receptor. These chapters also survey the various aspects of steroid receptors, including the specific acceptor sites in genes and their flanking sequences, the synthetic oligonucloetide acceptors for steroid receptor complexes, and the mechanisms of glucocorticoid resistance in leukemia.
Biochemists, biologists, and research workers who are interested in biochemical aspects of endocrinology will find this book invaluable.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.Vitamins are organic substances not naturally produced by the body that are necessary in trace amounts for normal physiologic and metabolic functioning. Hormones are biochemical substances produced in cells and tissues that cause a specific biological change or activity to occur elsewhere in the bodyStudy of both vitamins and hormones is essential to our understanding of physiology

Human Biochemistry includes clinical case studies and applications that are useful to medical, dentistry and pharmacy students. It enables users to practice for future careers as both clinicians and researchers.

The book also provides extensive online support for students to assist with further understanding and comprehension of advanced concepts, including sample questions that will help them prepare for medical exams. In addition, instructor’s ancillaries include PowerPoint presentations and testbanks.

Offering immediate application of biochemical principles into clinical terms in an updated way, this book is the unparalleled textbook for medical biochemistry courses in medical, dental and pharmacy programs.

Offers immediate application of biochemical principles into clinical terms in an updated wayContains coverage of the most current research in medical biochemistryPresents the first solution designed to reflect the needs of both research oriented and clinically oriented medical students

Klotho is the latest edition of a series first published in 1943 on Vitamins and Hormones and the longest-running serial published by Academic Press. It provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic, with volumes focusing on a single molecule or on a disease that is related to vitamins or hormones that are interpreted broadly so that related substances, such as transmitters, cytokines, growth factors, and others can be reviewed.Contains contributions from experts in the field of vitamins and hormonesCovers a vast array of subjectsIn-depth, current information at the molecular to clinical levels

Hormones provides a comprehensive treatment of human hormones viewed in the light of modern theories of hormone action and in the context of current understanding of subcellular and cellular architecture and classical organ physiology.
The book begins with discussions of the first principles of hormone action and the seven classes of steroid hormones and their chemistry, biosynthesis, and metabolism. These are followed by separate chapters that address either a classical endocrine system, e.g., hypothalamic hormones, posterior pituitary hormones, anterior pituitary hormones, ,thyroid hormones, pancreatic hormones, gastrointestinal hormones, calcium regulating hormones, adrenal corticoids, hormones of the adrenal medulla, androgens, estrogens and progestins, and pregnancy and lactation hormones; or newer domains of hormone action which are essential to a comprehensive understanding of hormone action, including prostaglandins, thymus hormones, and pineal hormones. The book concludes with a presentation of hormones of the future, i.e., cell growth factors.
This book is intended for use by first-year medical students, graduate students, and advanced undergraduates in the biological sciences. It is also hoped that this book will fill the void that exists for resource materials for teaching cellular and molecular endocrinology and that it will be employed as an equal partner with most standard biochemistry textbooks to provide a comprehensive and balanced coverage of this realm of biology.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on insulin and IGFs.

Longest running series published by Academic PressContributions by leading international authorities

Biochemical Actions of Hormones, Volume XIII is a 13-chapter text that explores the biochemical aspects of polypeptide, steroid, and insect hormones.
The opening chapters examine the control of glucose transport by insulin, the participation of nuclear poly(adenosine diphosphate-ribosyl)ation in hormonal mechanisms, and the concept of ovulation control. These topics are followed by discussions on the immunohistochemistry of human chorionic gonadotropin; the adrenocorticotropic hormone (ACTH) action on adrenal cholesterol metabolism and its interaction with adrenal receptors; the structure-activity relationships of neurohypophyseal hormones; and the interactions between different functional sites in the epidermal growth factor receptor. A chapter focuses on the juvenile hormone-binding proteins. The remaining chapters consider the actions of steroid hormones. These chapters specifically describe the androgen receptor, the interaction of the glucocorticoid receptors with specific DNA sequences, and glucocorticoid actions on fibroblasts. A discussion on the potential role of RNA in the glucocorticoid receptor mechanism is also included in these chapters.
This book will be of great benefit to endocrinologists, biochemists, biologists, and researchers who are interested in hormonal action and regulation.

First published in 1943, VITAMINS AND HORMONES is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, VITAMINS AND HORMONES continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

*Includes color illustrations
*Available on ScienceDirect
*Longest running series published by Academic Press
*Contributions by leading international authorities

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. Now, new discoveries have proved that several of the vitamins function as hormones and many of the substances inferred by the title of the Serial function in signal transduction processes. Accordingly, the Editor-in-Chief has expanded the scope of the serial to reflect this newer understanding of function-structure relationships in cellular communication. The newly modified Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.
Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This textbook is specifically designed for upper-division undergraduate or graduate students in life science or pre-medical majors including dentistry or pharmacology, who are required to take a biochemistry or medical biochemistry course, but who are not necessarily biochemistry majors. The book adopts a unique approach to the topic compared with other biochemistry textbooks currently available, in that each biochemical subject is introduced by a human disease relating the biochemical principles to be developed in that chapter. The goal is to make biochemistry more meaningful to the student who is not normally shown the connection between biochemistry and medicine.

Includes an abundance of figuresEmphasizes human biochemistryIntroduces each chapter with a relevant disease or clinical relationship

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on obesity.

Contributions from leading authoritiesInforms and updates on all the latest developments in the field

The purpose of these volumes is to provide a reference work for the methods of purifying many of the receptors we know about. This be comes increasingly important as full-length receptors are overexpressed in bacteria or in insect cell systems. A major problem for abundantly expressed proteins will be their purification. In addition to purification protocols, many other details can be found concerning an individual receptor that may not be available in standard texts or monographs. No book of this type is available as a compendium of purification procedures. Receptor Purification provides protocols for the purification of a wide variety of receptors. These include receptors that bind: neurotransmit ters, polypeptide hormones, steroid hormones, and ligands for related members of the steroid supergene family and others, including receptors involved in bacterial motion. The text of this information is substantial, so as to require its publication in two volumes. Consequently, a division was made by grouping receptors by the nature of their ligands. Thus, in Volume One there are contributions on serotonin receptors, adrenergic receptors, the purification of GTP-binding proteins, opioid receptors, neurotensin receptor, luteinizing hormone receptor, human chorionic gonadotropin receptor, follicle stimulating hormone receptor, thyro tropin receptor, prolactin receptor, epidermal growth factor receptor, platelet derived growth factor receptor, colony stimulating factor recep tor, insulin-like growth factor receptors, insulin receptor, fibronectin receptor, interferon receptor, and the cholecystokinin receptor.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on the pancreatic beta cell.

Expertise of the contributorsCoverage of a vast array of subjectsIn depth current information at the molecular to the clinical levelsThree-dimensional structures in colorElaborate signaling pathways

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

*First published in 1943, Vitamins and Hormones is AP's longest running serial
*Each volume contains cutting edge reviews by leading contributors

Neurotrophins, the latest volume in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions, and the biological actions of neurotrophins related to clinical conditions and disease. Each volume is thoroughly reviewed and focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances such as transmitters, cytokines, growth factors, and others.Provides cutting-edge reviews concerning the molecular and cellular biology of vitamins and hormonesContains expertise from world-renowned contributorsFocuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances such as transmitters, cytokines, growth factors, and othersPresents in-depth, current information from the molecular to clinical level

Erythropoietin, the latest volume in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions and the biological actions of neurotrophins related to clinical conditions and disease.

Each thoroughly reviewed volume focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances, such as transmitters, cytokines, growth factors and others.

Erythropoietin is a kidney cytokine-like hormone that is responsible for maintaining the homeostasis of oxygen in the circulation. In case of hypoxia or anemia, erythropoietin acts through a complex regulatory system involving the hypoxia-inducible factor and hypoxia-response elements in the genome to cause red blood cells to proliferate and differentiate. Although this system has been understood to account for the main activity of erythropoietin, it is currently known that erythropoietin has many other additional physiological activities. This volume documents the activities of this vital molecule and also describes the structure and function of erythropoietin and its receptor as well as newly designed small-molecule agonists.

Presents the latest information on erythropoietinProvides a long-running series that focuses on updates and advances in vitamins and hormonesCovers single molecules or diseases that are related to vitamins or hormones, with the topic broadly interpreted to include related substances

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

Contributions from leading authoritiesInforms and updates on all the latest developments in the field

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on endocrine disrupters.

Expertise of the contributorsCoverage of a vast array of subjects In depth current information at the molecular to the clinical levelsThree-dimensional structures in colorElaborate signaling pathways

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on insulin and IGFs.

Longest running series published by Academic PressContributions by leading international authorities

The longest running serial published by Academic Press continues its well-respected run with Volume 61, a special volume in which a guest editor has come on board and has assembled some well-known contributors who are international authorities in the field. Together they tackle some of the latest topics in the field such as riboflavin and folate biosynthesis, biotin and lipoic acid biosynthesis, nicotinamide adenine dinucleotide biosynthesis, biosynthesis of vitamin B6 and structurally related derivatives, pantothenic acid and coenzyme A biosynthesis, mechanistic biosynthesis of protein-derived redox cofactors, ascorbic acid biosynthesis, biosynthesis of menaquinone and ubiquinone - Vitamin B12 biosynthesis, biosynthesis of the methanogenic cofactors, and thiamin biosynthesis.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on sleep hormones.

Contributions from leading authoritiesInforms and updates on all the latest developments in the field

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

The newly revised and updated Hormones, Second Edition provides a comprehensive treatment of human hormones, viewed in light of modern theories of hormone action and in the context of current understanding of subcellular and cellular architecture and classical organ physiology. Each chapter presents a physiological description of the hormone system under consideration, followed by a listing of the mode-of-action of the hormone. This book includes significant advances in the molecular biology of receptors, hormones, and studies of hormone action that have transpired over the past five years. The text updates the material on enzymes related to steroid metabolism and new hormone systems, as well as providing a new chapter on hormones and cancer.Completely updates the material, covering new discoveries and significant advances since the First Edition was published in 1987Contains new information regarding steroid hormones, the role of hormones in cancer, and a comprehensive introductory chapterPresents an overview of virtually all important hormonesProvides detailed physiological, cellular, and molecular descriptions of classical human endocrine systemsStreamlines the presentation of the First Edition, making the book easier to use and read

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on hormones of the limbic system.

Longest running series published by Academic PressContributions by leading international authorities

Biochemical Actions of Hormones, Volume I explores the significant developments toward understanding the primary effects of hormones in cellular receptors at the molecular level. This book is composed of 12 chapters that survey the molecular and biochemical approaches bearing on the problem of hormone mechanism.
The opening chapters discuss the thyroid hormonal responses during metamorphic process in Amphibia; the primary role of hormones in biochemical differentiation; the influence of hormones on protein synthesis and the importance of protein synthesis mechanism; and the biochemical rhythms within the pineal gland and the rhythm in hepatic tyrosine transaminase activity. The subsequent chapters examine the effects of a number of hormones on transport systems in the cell membranes, the protein interaction with steroids, and the influence of insulin on protein and nucleic acid metabolism. The remaining five chapters deal with the physiology, mechanism of action, and biological effects of various hormones, such as mineralocorticoids, parathyroid hormone, calcitonin, thyrotropin, and plant hormones.
This book is an invaluable source for endocrinologists.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on insulin and IGFs.

*Longest running series published by Academic Press
*Contributions by leading international authorities

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. Now, new discoveries have proved that several of the vitamins function as hormones and many of the substances inferred by the title of the serial function in signal transduction processes. Accordingly, the Editor-in-Chief has expanded the scope of the serial to reflect this newer understanding of function-structure relationships in cellular communication. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.
This volume comprises three groups of contributors. The first three papers deal with receptors and their actions. The second group of three papers are on diabetes and specific hormones. The last three papers are presentations on various aspects of vitamins and growth factors.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume reviews recent advances in the formation of endogenous cannabinoids and their receptors, metabolism and relation to disease processes.

*Longest running series published by Academic Press *Contributions by leading international authorities

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on hormone and transport systems.

Expertise of the contributorsCoverage of a vast array of subjectsIn depth current information at the molecular to the clinical levels

Steroids is a thematic volume from the classic Academic Press series, Vitamins and Hormones. Gerald Litwack, the new editor of this prestigious serial, brings together leading contributors to the study of steroids. These structurally and functionally complex molecules are of interest to a broad cross-section of endocrinologist, cell biologists, and biochemists. Reviews include studies of structure, function, and regulation of steroid production and action. Thus, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists and biochemists. Others will increasingly turn to this continuing series for comprehensive reviews by leading researchers in this and related disciplines.

Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board reflects expertise in the fields of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Every volume contains comprehensive reviews by leading contributors.

First published in 1943, VITAMINS AND HORMONES is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, VITAMINS AND HORMONES continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

* First published in 1943, Vitamins and Hormones is AP's longest running serial
* Each volume contains cutting edge reviews by leading contributors

Biochemical Actions of Hormones, Volume III is a collection of papers that deals with steroid hormone action, hypothalamic-regulating hormones, plasma membrane receptors, thyroid hormones, hormones acting on the synthesis of proteins in liver perfusion systems, as well as on approaches using genetics and cell culture. One paper explains why cell hybridization can be a useful technique in studying both genetic control of differentiated functions and of hormonal induction. Another paper discusses the general approaches in the study of ligand-membrane interactions, and cites experiments dealing with polypeptide hormones and catecholamines. It explains in detail the physiochemical interaction between a radioactively labeled ligand and the plasma membrane, either as found in an intact cell or in an isolated membrane preparation. One paper discusses the introduction and time course of estrogen-stimulated biosynthetic events in the uterus. It analyzes the relationship of the estrogen-binding protein to the biological responses of the uterus, including the "domino" versus "sustained output" model of estrogen action. One paper explains, by using a chick oviduct, how to investigate the hypothesis that hormones can activate genes to allow transcription of new species of messenger RNA. This collection can prove beneficial to biochemists, molecular biologists, cellular biologists, micro-biologists, developmental biologists, and scientists involved in cell research.

Cell death is one of the fundamental processes by which normal development is modulated, and the importance of both necrosis and apoptosis in a number of pathologies has generated intense interest from researchers in many fields. This timely book covers both the proteins that are produced by dying cells and the proteins that signal cells to initiate cell death.
Cell Death Proteins provides an overview of the explosive interest in cellular death. Six review papers, written by researchers at the forefront of this rapidly moving field, focus on proteins that promote, signal, and inhibit cell death. Major players involved in the cell death cascade and its controls are covered, including cell cycle checkpoints, the function of interleukin-1J converting enzyme, the role of IGF-I receptor, the Bcl-2 family of proteins, viral inhibitors of apoptosis, and p53-dependent apoptosis.

General Description of Volume:
Volume 51 includes reviews papers on cyclic AMP, kinases, polypeptide hormones, steroid hormone receptors, related genes, and members of the gene family.
General Description of Series:
Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish up-to-date synthetic reviews of interest to endocrinologists and biochemists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. Now, new discoveries have proved that several of the vitamins function as hormones and many of the substances inferred by the title of the Serial function in signal transduction processes. Accordingly, the editor-in-chief has expanded the scope of the serial to reflect this newer understanding of function-structure relationships in cellular communication. The newly modified editorial board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Vitamins and Hormones continues to publish up-to-date synthetic reviews of interest to endocrinologists and biochemists. Others will increasingly turn to this series for comprehensive reviews by leading researchers in this and related disciplines.

Biochemical Actions of Hormones, Volume XI is a 12-chapter text that covers the general and specific biochemical aspects of polypeptide and steroid hormones.
The introductory chapters deal with the biochemical actions of the leukotrienes, the cyclic adenosine monophosphate, and the gonadotropin releasing hormone. The next chapters highlight detailed contributions on polypeptide hormone research. These chapters specifically tackle the insulin actions and the role of insulin in mammary gland development. The last series of chapters on steroid hormones includes X-ray crystallographic analysis of steroid structures and the significance of these studies on steroid-receptor interactions. These chapters also explore the analysis of the estrogen receptor with monoclonal antibodies; the role of estrogen receptor in responsive mammalian cells; the use of peroxidase as a marker of catechol estrogen action; and the activation and stabilization of the glucocorticoid receptor.
This volume will be of great benefit to biochemists, biologists, endocrinologists, and researchers who are interested in the hormonal action and regulation.

 

What is neuroplasticity? Is it possible to change your brain? Norman Doidge’s inspiring guide to the new brain science explains all of this and more

An astonishing new science called neuroplasticity is overthrowing the centuries-old notion that the human brain is immutable, and proving that it is, in fact, possible to change your brain. Psychoanalyst, Norman Doidge, M.D., traveled the country to meet both the brilliant scientists championing neuroplasticity, its healing powers, and the people whose lives they’ve transformed—people whose mental limitations, brain damage or brain trauma were seen as unalterable. We see a woman born with half a brain that rewired itself to work as a whole, blind people who learn to see, learning disorders cured, IQs raised, aging brains rejuvenated, stroke patients learning to speak, children with cerebral palsy learning to move with more grace, depression and anxiety disorders successfully treated, and lifelong character traits changed. Using these marvelous stories to probe mysteries of the body, emotion, love, sex, culture, and education, Dr. Doidge has written an immensely moving, inspiring book that will permanently alter the way we look at our brains, human nature, and human potential.

From the Trade Paperback edition.

The irresistible, ever-curious, and always best-selling Mary Roach returns with a new adventure to the invisible realm we carry around inside. “America’s funniest science writer” (Washington Post) takes us down the hatch on an unforgettable tour. The alimentary canal is classic Mary Roach terrain: the questions explored in Gulp are as taboo, in their way, as the cadavers in Stiff and every bit as surreal as the universe of zero gravity explored in Packing for Mars. Why is crunchy food so appealing? Why is it so hard to find words for flavors and smells? Why doesn’t the stomach digest itself? How much can you eat before your stomach bursts? Can constipation kill you? Did it kill Elvis? In Gulp we meet scientists who tackle the questions no one else thinks of—or has the courage to ask. We go on location to a pet-food taste-test lab, a fecal transplant, and into a live stomach to observe the fate of a meal. With Roach at our side, we travel the world, meeting murderers and mad scientists, Eskimos and exorcists (who have occasionally administered holy water rectally), rabbis and terrorists—who, it turns out, for practical reasons do not conceal bombs in their digestive tracts.

Like all of Roach’s books, Gulp is as much about human beings as it is about human bodies.

Neil Shubin, the paleontologist and professor of anatomy who co-discovered Tiktaalik, the “fish with hands,” tells the story of our bodies as you've never heard it before. The basis for the PBS series.

By examining fossils and DNA, he shows us that our hands actually resemble fish fins, our heads are organized like long-extinct jawless fish, and major parts of our genomes look and function like those of worms and bacteria. Your Inner Fish makes us look at ourselves and our world in an illuminating new light. This is science writing at its finest—enlightening, accessible and told with irresistible enthusiasm.

Everything you believe about how to lose weight is wrong. Weight gain and obesity are driven by hormones—in everyone—and only by understanding the effects of insulin and insulin resistance can we achieve lasting weight loss.

In this highly readable and provocative book, Dr. Jason Fung sets out an original, robust theory of obesity that provides startling insights into proper nutrition. In addition to his five basic steps, a set of lifelong habits that will improve your health and control your insulin levels, Dr. Fung explains how to use intermittent fasting to break the cycle of insulin resistance and reach a healthy weight—for good.

A New York Times / National Bestseller

"America's funniest science writer" (Washington Post) Mary Roach explores the science of keeping human beings intact, awake, sane, uninfected, and uninfested in the bizarre and extreme circumstances of war.

Grunt tackles the science behind some of a soldier's most challenging adversaries—panic, exhaustion, heat, noise—and introduces us to the scientists who seek to conquer them. Mary Roach dodges hostile fire with the U.S. Marine Corps Paintball Team as part of a study on hearing loss and survivability in combat. She visits the fashion design studio of U.S. Army Natick Labs and learns why a zipper is a problem for a sniper. She visits a repurposed movie studio where amputee actors help prepare Marine Corps medics for the shock and gore of combat wounds. At Camp Lemmonier, Djibouti, in east Africa, we learn how diarrhea can be a threat to national security. Roach samples caffeinated meat, sniffs an archival sample of a World War II stink bomb, and stays up all night with the crew tending the missiles on the nuclear submarine USS Tennessee. She answers questions not found in any other book on the military: Why is DARPA interested in ducks? How is a wedding gown like a bomb suit? Why are shrimp more dangerous to sailors than sharks? Take a tour of duty with Roach, and you’ll never see our nation’s defenders in the same way again.

“A model of scientific writing: erudite, witty, and clear.” —New York Review of Books In this Pulitzer Prize finalist and national bestseller, one of the world's leading cognitive scientists tackles the workings of the human mind. What makes us rational—and why are we so often irrational? How do we see in three dimensions? What makes us happy, afraid, angry, disgusted, or sexually aroused? Why do we fall in love? And how do we grapple with the imponderables of morality, religion, and consciousness? ?How the Mind Works? synthesizes the most satisfying explanations of our mental life from cognitive science, evolutionary biology, and other fields to explain what the mind is, how it evolved, and how it allows us to see, think, feel, laugh, interact, enjoy the arts, and contemplate the mysteries of life. This new edition of Pinker's bold and buoyant classic is updated with a new foreword by the author.

A groundbreaking workout and diet plan that replenishes a man's testosterone levels, rebuilds his body, and remakes his life

Testosterone is the most crucial hormone in the male body--and every man's T levels begin a slow, steady decline as he ages. The result? Loss of strength and muscle mass. Poor sugar metabolism. Increased body fat, especially around the waist. Loss of T also affects red blood cell production, vitality, bone density, mental acuity, and sex drive. In short: It slowly chops a man down.

Testosterone Transformation helps a man produce higher levels of T and reverse the downward spiral. By eating the right foods and adopting a new exercise approach, any man at any age can transform his life by starting a positive chain reaction: Raise T levels through the strategies in this book, improve workouts, get stronger, improve workouts even more, get even stronger, and enable the body to use muscle to process sugar--instead of storing it as fat.

Testosterone Transformation is a life-changer: a serious exercise and strategic diet plan that uses the science of a man's own body to help him recharge his sex drive, increase vitality, and reduce health risks across the board.

From one of our finest and most popular science writers, the best-selling author of Your Inner Fish, comes the answer to a scientific mystery story as big as the world itself: How have astronomical events that took place millions of years ago created the unique qualities of the human species?

In his last book, Neil Shubin delved into the amazing connections between human anatomy—our hands, our jaws—and the structures in the fish that first took over land 375 million years ago. Now, with his trademark clarity and exuberance, he takes an even more expansive approach to the question of why we are the way we are. Starting once again with fossils, Shubin turns his gaze skyward.  He shows how the entirety of the universe's 14-billion-year history can be seen in our bodies. From our very molecular composition (a result of stellar events at the origin of our solar system), he makes clear, through the working of our eyes, how the evolution of the cosmos has had profound effects on the development of human life on earth.


From the Hardcover edition.

From the author of the New York Times bestseller The Autoimmune Solution, a comprehensive, accessible overview of thyroid problems that will help you learn to identify the warning signs and finally take back your health.

Are you exhausted all the time, plagued by brain fog, and unable to lose weight? Do you struggle with insomnia, panic attacks, and tremors? But does your doctor insist that your labs are normal, and that you just need to eat less and exercise more? As anyone who has been there knows, nothing is more frustrating, stressful, and emotionally draining than feeling unwell and being told you're fine by the very person who is supposed to heal you.

The truth is, your symptoms could be caused by a thyroid disorder--the hidden cause behind a wide array of health problems that can threaten to ruin your life. Thyroid dysfunctions like Hashimoto's disease, hypothyroidism, and hyperthyroidism affect at least 20 million Americans and yet conventional medicine frequently misses the diagnosis. The scariest part? Most doctors won't even order thyroid tests unless you specifically ask.

Now, in The Thyroid Connection, Dr. Amy Myers teaches you how to take your health into your own hands. Dr. Myers, originally misdiagnosed herself, understands the struggles of thyroid dysfunction firsthand. Fortunately, she also knows how achievable recovery and well-being are, and just how to get you there. In The Thyroid Connection, you'll discover:
How to work with your doctor to get the correct diagnosisWhat blood tests to ask for, as well as what they meanHow to find the right type and dose of supplemental thyroid hormone for youThe role of gut health, diet, toxins, infections, and stress in thyroid dysfunctionA complete 28-day plan to jumpstart your health and reverse your thyroid symptoms
Complete with advice on diet and nutrition, supplements, exercise, stress relief, and sleep, The Thyroid Connection is the ultimate roadmap back to your happiest, healthiest self.

A shocking look at the link between sugar, inflammation, and a host of preventable chronic diseases—perfect for fans of bestselling author Gary Taubes’ The Case Against Sugar—from leading nerve surgeon Dr. Richard Jacoby.

 

What Grain Brain did for wheat, this book by a leading peripheral nerve surgeon now does for sugar, revealing how it causes crippling nerve damage throughout the body—in our feet, organs, and brain—why sugar and carbohydrates are harmful to the body's nerves, and how eliminating them can mitigate and even reverse the damage.

If you suffer from ailments your doctors can’t seem to diagnose or help—mysterious rashes, unpredictable digestive problems, debilitating headaches, mood and energy swings, constant tiredness—nerve compression is the likely cause. Sugar Crush exposes the shocking truth about how a diet high in sugar, processed carbohydrates, and wheat compresses and damages the peripheral nerves of the body, leading to pain, numbness, and tingling in the hands and feet, along with a host of related conditions, including migraines, gall bladder disease, and diabetes.

Over the years, Dr. Richard Jacoby has treated thousands of patients with peripheral neuropathy. Now, he shares his insights as well as the story of how he connected the dots to determine how sugar is the common denominator of many chronic diseases. In Sugar Crush, he offers a unique holistic approach to understanding the exacting toll sugar and carbs take on the body. Based on his clinical work, he breaks down his highly effective methods, showing how dietary changes reducing sugar and wheat, coinciding with an increase of good fats, can dramatically help regenerate nerves and rehabilitate their normal function.

Sugar Crush includes a quiz to assess your nerve damage, practical dietary advice, and the latest thinking on ways to prevent and reverse neuropathy. If you have diabetes, this essential guide will help you understand the dangers and give you the tools you need to make a difference beyond your doctor’s prescriptions. If you have the metabolic syndrome or prediabetes, or are just concerned about your health, it will help you reverse and prevent nerve damage.