The AJCC Cancer Staging Atlas, 2nd Edition, is an official publication of the American Joint Committee on Cancer, the recognized international leader in state-of-the-art information on cancer staging. This Atlas has been created as a companion to the updated 7th Edition of the AJCC Cancer Staging Manual, which continues to disseminate the importance of anatomical and pathological staging in the management of cancer. This state-of-the-art, invaluable 2nd Edition includes a CD containing PowerPoint slides of all illustrations, additional color, and a user-friendly, easy-to-read layout. The AJCC Cancer Staging Atlas, 2nd Edition will serve as an indispensable reference for clinicians, registrars, students, trainees, and patients.
Introduces cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancerCovers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicineSummarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities
A Doody's Core Title for 2017!
Featuring a superb compilation of chapters related to hematology and oncology derived from Harrison’s Principles of Internal Medicine, Nineteenth Edition (including content from the acclaimed Harrison’s DVD, now available here in print), this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s. You will find 57 chapters from more than 75 renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation.
• Each chapter contains relevant information on the genetics, cell biology, pathophysiology, and treatment of specific disease entities
• Chapters on hematopoiesis, cancer cell biology, and cancer prevention reflect the rapidly growing knowledge in these areas
• Integration of pathophysiology with clinical management
• High-yield board review questions make this text ideal for keeping current or preparing for the boards
• Valuable appendix of laboratory values of clinical importance
Presented in a handy, easy-to-read format, Dx/Rx: Liver Cancer is a must-have resource for oncologists, internists, primary care physicians, and other health care professionals on the ward or in the clinic.
Written in joint collaboration by residents and staff radiation oncologists at the Department of Radiation Oncology at the Cleveland Clinic Taussig Cancer Institute, the book contains more than 900 questions addressing the full gamut of the science and practice of radiation oncology today.
Radiation Oncology Self-Assessment Guide Features: Comprehensive coverage of radiation oncologyFlash-card" format facilitates recall of key data, treatment assessment and patient management, and important original studiesOrganized by the major subject areas in radiation oncology, the question sets feature structured questions and nswers designed to test recall and sharpen skillsAuthors are from the Department of Radiation Oncology at the Cleveland Clinic Taussig Cancer Institute
Each chapter is concise but highlights the basic tenets health care professionals working with cancer patients need to know to understand the diseases and current treatment options. To facilitate review, Key Points are boxed in each chapter to summarize important clinical information and concepts at a glance. This book represents a synthesis of information from some of the top physicians in oncology that is not as easily accessed anywhere else.
Features of Synopsis of Clinical Oncology include:Multi-specialty expert authorshipFocus on therapeutics management of cancerKey Points boxed in each chapter for quick review
The Guide is comprised of 14 chapters that lead the reader through the radiation oncology physics field, from basic physics to current practice and latest innovations. Aspects of basic physics covered include fundamentals, photon and particle interactions, and dose measurement. A section on current practice covers treatment planning, safety, regulations, quality assurance, and SBRT, SRS, TBI, IMRT, and IGRT techniques. A chapter unique to this volume is dedicated to those topics in diagnostic imaging most relevant to radiology, including MRI, ultrasound, fluoroscopy, mammography, PET, SPECT, and CT. New technologies such as VMAT, novel IGRT devices, proton therapy, and MRI-guided therapy are also incorporated. Focused and authoritative, this must-have review combines the expertise of clinical radiation oncology and radiation physics faculty from the Cleveland Clinic Taussig Cancer Institute.
Includes more than 800 questions with detailed answers and rationales
A one-stop guide for those studying the physics of radiation oncology including those wishing to reinforce their current knowledge of medical physics
Delivered in a ìflash cardî format to facilitate recall of key concepts and data
Presents a unique chapter on diagnostic imaging topics most relevant to radiation oncology
Content provided by a vast array of contributors, including physicists, radiation oncology residents, dosimetrists, and physicians
About the Editors:
Andrew Godley, PhD, is Staff Physicist, Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland OH
Ping Xia, PhD, is Head of Medical Physics and Professor of Molecular Medicine, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
The book covers basic concepts such as anatomy, physiology, pharmacology, and mathematical models of drug transport as well as practical clinical applications, highlighted with results from clinical trials and promising novel preclinical developments.
The book is a state-of-the-art reference for surgical and medical oncologists interested in the treatment of carcinomatosis. It also establishes and promotes basic and translational research interest in the field of intraperitoneal drug delivery, which has the potential to improve the outcome for this dreaded condition. Edited by two renowned surgical oncologists, it represents the definitive reference in the field of intraperitoneal cancer therapy.
Presented in an easy-to-read format, Dx/Rx: Lung Cancer, Second Edition is a must-have resource for oncologists, internists, primary care physicians, and other health care professionals on the ward or in the clinic.
More than 500 treatment regimens
Hematology-Oncology Therapy, Second Edition is an up-to-date, comprehensive therapy guide that delivers more than 500 treatment regimens in a succinct, uniform manner. The unique tabular design allows you to instantly locate and implement the proper treatment regimen. Supported by the latest practice guidelines, peer-reviewed literature, and the opinion of experts, Hematology-Oncology Therapy integrates extensive information that is critical to both office- and hospital-based practice of hematology and oncology.
Hematology-Oncology Therapy is divided into three sections:
Provides detailed information about the administration, supportive care, toxicity, dose modification, monitoring, and efficacy of commonly used and recently approved chemotherapeutic regimens, drugs, and biological agents
Supportive Care, Drug Preparation, Complications, and Screening:
Consists of topics commonly encountered in clinical hematology-oncology practice, such as chemotherapy-induced nausea, oncologic emergencies, radiation complications, cancer pain management, cancer screening, and much more
Selected Hematologic Diseases:
Delivers an authoritative guide to therapy for the principal diseases in consultative hematology
This edition of Hematology-Oncology Therapy is enriched by the updating of all chapters as well as the addition of several new chapters; the new "Expert Opinion," which provides recommendations and guidance from experts on the use of treatment regimens; and inclusion of the latest regimens.
Written by two expert oncologists specializing in pancreatic cancer, Dx/Rx: Pancreatic Cancer is a concise pocket reference for all professional caregivers of patients with pancreatic cancer. This handy guide provides comprehensive, up-to-date information on the epidemiology, symptoms, diagnosis, and management of malignancies of the pancreas. Topics include detailed outline of the diagnosis process and staging, molecular pathogenesis, localized diseases and advanced cases, metastatic pancreatic cancer, uncommon pancreatic malignancies, and information on supportive care. Presented in a quick-reference format, Dx/Rx: Pancreatic Cancer is an essential guide for on the ward or in the clinic.
Key features include:
* Up-to-date review of major topics in neuro-oncology, presented in a concise, easy-to-read format
* In-depth discussion of tumors affecting the central and peripheral nervous systems, such as gliomas, meningiomas, brain metastases and neoplastic meningitis
* Treatment strategies for the most common tumors
* Essential information about neurologic complications of cancer and cancer therapies, including cognitive impairment from chemotherapy and radiation, peripheral neuropathy, paraneoplastic disorders, strokes and seizures
Key features include:
Written by a medical oncologist with a thorough discussion of systemic therapy of melanoma
In-depth look at novel treatments being developed for advanced melanoma, including a discussion of all major recent studies
Discussion of the molecular biology of melanoma and the treatment implications
Cancer Biology Review is a useful tool for any oncology clinician in training or preparing for boards, and for the oncology practitioner preparing for recertification or who sees the need to be more fully conversant in the current science of the field as clinically applied.Features of Cancer Biology Review include:Presents principles of cancer biology through clinical translations and therapeutic perspective Clinical cases illustrate scientific principles as the clinician will observe them in practice Emphasis on scientific basis of current and emerging therapeutics Leading translational scientists/clinicians provide current, authoritative discussions
This issue of Radiation Medicine Rounds discusses the more salient topics surrounding the role of radiation therapy for malignant gliomas. The specialty of radiation therapy has increased in complexity over the years, yet as technology improves, the goal of improving outcomes while decreasing toxicity remains critical. Malignant gliomas remain among the most devastating of all malignancies, yet as conventional treatments (surgery, radiation, and chemotherapy) have become optimized overall survival has improved. The underlying molecular and genetic mechanisms of these tumors are becoming better understood, with one of the most important realizations being that histopathologically identical malignant gliomas often demonstrate very distinct clinical behaviors. Malignant Gliomas provides the practitioner with a current overview of best practices, recent research, and future directions in the management of this complex and challenging cancer.
Traumatized and terrified of cancer? Perhaps you have been diagnosed yourself, or you have a friend or family member who is battling with the disease. You know you must face it—but you do not have to face it alone. Praying Through Cancer is a collection of stories by women who have faced cancer and, with triumphant spirits, found comfort and sometimes even joy in the midst of it.
For these women, cancer was a comma, not a period, in the sentences of their lives. Why? Because they put their faith in the Lord and He strengthened them beyond comprehension. You will laugh and you will cry, but best of all, you will know . . . you are not alone.
Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may have implications for developing new treatments. The current volume provides an overview of the field and how various cell biology techniques are used to better understand cancer on a cellular level. This easily accessible reference volume offers a comprehensive look at the field of cancer cell signaling. Edited by a researcher from Florida Atlantic University, Cancer Cell Signaling: Targeting Signaling Pathways Towards Therapeutic Approaches to Cancer is an authoritative and easy-to-use reference.
A masterful synchronization of history and cutting-edge science shines new light on humanity's darkest diagnosis.
In the wake of the Cancer Genome Atlas project's failure to provide a legible roadmap to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease. Tripping over the Truth follows the story of cancer’s proposed metabolic origin from the vaunted halls of the German scientific golden age to modern laboratories around the world. The reader is taken on a journey through time and science that results in an unlikely connecting of the dots with profound therapeutic implications.
Transporting us on a rich narrative of humanity’s struggle to understand the cellular events that conspire to form malignancy, Tripping over the Truth reads like a detective novel, full of twists and cover-ups, blind-alleys and striking moments of discovery by men and women with uncommon vision, grit, and fortitude. Ultimately, Christofferson arrives at a conclusion that challenges everything we thought we knew about the disease, suggesting the reason for the failed war against cancer stems from a flawed paradigm that categorizes cancer as an exclusively genetic disease.
For anyone affected by this terrifying disease and the physicians who struggle to treat it, this book provides a fresh and hopeful perspective. It explores the new and exciting non-toxic therapies born from the emerging metabolic theory of cancer. These therapies may one day prove to be a turning point in the struggle against our ancient enemy. We are shown how the metabolic theory redraws the battle map, directing researchers to approach cancer treatment from a different angle, framing it more like a gentle rehabilitation rather than all-out combat. In a sharp departure from the current “targeted” revolution occurring in cancer pharmaceuticals, the metabolic therapies highlighted have one striking feature that sets them apart—the potential to treat all types of cancer because they exploit the one weakness that is common to every cancer cell: dysfunctional metabolism.
With contributions from Thomas Seyfried, PhD, author of Cancer as a Metabolic Disease; Miriam Kalamian, EdM, MS, CNS, author of Keto for Cancer; and Beth Zupec Kania, consultant nutritionist of The Charlie Foundation.
For more than two decades, readers faced with a diagnosis of breast cancer have relied on Dr. Susan Love's Breast Book to guide them through the frightening thicket of research and opinion to find the best options for their particular situations. This sixth edition explains advances in targeted treatments, hormonal therapies, safer chemotherapy, and immunologic approaches as well as new forms of surgery and radiation. There is extensive guidance for the many women now living for years with metastatic breast cancer. With Dr. Love's warm support, readers can sort the facts from the fads, ask the right questions, and recognize when a second opinion might be wise.
Lanzkowsky’s Manual of Pediatric Hematology and Oncology, Sixth Edition,is a comprehensive book on patient management, replete with algorithms and flow diagrams on diagnosis and management. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the sixth edition of this successful clinical manual has been entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format will enable readers to make accurate diagnoses and permit them to treat patients without having to reference larger medical textbooks.
Based on the new standards of genetic classification and prognostic information that have arisen in the past five years, the sixth edition includes two new chapters (Diagnostic, Molecular, and Genomic Methodologies for the Hematologist, Transfusion Medicine) and several new expanded chapters that were previously sections in consolidated chapters (Myelodysplasia, Myeloid Leukemias, Lymphoid Leukemias, Hemolytic Anemia, and Disorders of Coagulation).Presents a concise, systematic approach to all pediatric hematologic and oncologic disorders in one manualOffers an alternative to bigger references which only cover either oncologic or hematologic disorders in twice as many pagesPresents an easy-to-read format: multiple tables, charts, and flow-diagrams for diagnosis and management of pediatric hematologic and oncologic disordersIncludes 2 new chapters and several expanded chapters: Diagnostic, Molecular and Genomic Methodologies for the Hematologist, Transfusion Medicine, Myelodysplasia, Myeloid Leukemias, and Lymphoid Leukemias
In this groundbreaking book, Gary Null debunks the commonly accepted belief that drugs and chemotherapy are the only cures for cancer and explores the alternative treatments that most mainstream doctors will never discuss with their patients. Dr. Null asserts that there are foods and supplements that boost the body’s immune system and can actually prevent and reverse cancer. Did you know that eating lemons and melons can help balance your body’s pH, which will help prevent and treat cancer? You knew that fiber is important for a healthy diet, but did you know that it lowers the risk of breast, colorectal, uterine, and prostate cancers? Have you heard of maitake mushrooms, which kill cancer cells by enhancing the activity of T-helper cells? In addition to diet, Dr. Null discusses important supplements and herbs and cutting-edge therapies you may never have heard of. With twenty-five cancer-fighting recipes and testimonials from individuals who have found health through Dr. Null’s methods, this book could save your life.
These therapies notably include:
Targeted agents of immune checkpoints
Stem cell inhibitors
Tumor profiling for drug development
The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world.
Cancer is not randomly distributed in the United States. Its incidence varies by race, ethnicity, socioeconomic status, and other geographic and demographic factors. This volume, co-published with the American Cancer Society, is the first to examine the biological, racial, and socioeconomic factors that influence cancer incidence and survival. In addition, it presents 15 previously unpublished, evidence-based interventions to reduce and eliminate cancer disparities.
The book explains the nature, scope, and causes of cancer disparities across different populations and then presents unique programs proven to reduce such inequalities in the areas of cancer prevention, screening and early detection, treatment, and survivorship. They represent a variety of cancers, populations, and communities across the U.S. Descriptions of each intervention include tests of effectiveness and are written in sufficient detail for readers to replicate them within their own communities.Key Features:
Offers an in-depth look at the latest research behind cancer disparitiesWritten by highly respected and published cancer researchersIncludes 15 never-before published, evidence-based interventions that readers can replicateDiscusses breast, colorectal, cervical, and other pernicious cancersIncludes interventions for African-American, Hispanic, Native American, and other populations
Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers.
With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.
Contains practical information for immediate clinical applicationCovers topics such as patient safety, error prevention, quality improvement, errors disclosure and apology, and the impact of errors on patients and doctorsEach chapter contains special "take home" points that highlight issues of particular clinical relevance and applicationPrepared by an expert, multidisciplinary, international team of physicians, nurses, researchers, hospital administrators, bioethicists, patients and patient advocates
Dr. Surbone shared with ASCO Connection her insights about patient safety and medical errors and offered a glimpse into the history that led to this new book:
Essentials of Clinical Radiation Oncology has been designed to replicate a "house manual" created and used by residents in training and is a "one-stop" resource for practicing radiation oncologists, related practitioners, and radiation oncology residents entering the field.
Key Features:Offers digestible information as a learning guide for general practice Examines essential clinical questions which are answered with evidence-based data from important clinical studies Places clinical trials and data into historical context and points out relevance in current practice Provides quick reference tables on treatment options and patient selection, workup, and prognostic factors by disease site
Rancour has an honest, humane, funny, and poetic style. She sweeps you along with her compassion, her wit, and her unerring ability to see into the truth of the matter. This book is for anyone who has an interest in what goes on in the patient rooms, hallways, stairwells, and elevators of a cancer hospital. You wont be able to put it down.
Over the past half century, deaths from heart disease, stroke, and so many other killers have fallen dramatically. But cancer continues to kill with abandon. In 2013, despite a four-decade “war” against the disease that has cost hundreds of billions of dollars, more than 1.6 million Americans will be diagnosed with cancer and nearly six hundred thousand will die from it.
A decade ago, Clifton Leaf, a celebrated journalist and a cancer survivor himself, began to investigate why we had made such limited progress fighting this terrifying disease. The result is a gripping narrative that reveals why the public’s immense investment in research has been badly misspent, why scientists seldom collaborate and share their data, why new drugs are so expensive yet routinely fail, and why our best hope for progress—brilliant young scientists—are now abandoning the search for a cure. “Through flowing prose Leaf delivers, alongside facts and data, stories on personalities involved in research, the fascinating process of solving an unusual and highly deadly cancer in Africa, and the heartbreaking realities of cancer treatment in children today. Leaf’s extensively investigated treatise will resonate with researchers and patients frustrated by the bureaucratic woes he delineates. Public policy makers, grant reviewers, and pharmaceutical researchers alike must consider Leaf’s indictment and proposed solutions” (Publishers Weekly). The Truth in Small Doses is that rare tale that will both outrage readers and inspire conversation and change.
Co-written by a former radiation oncology residency program director and a team of radiation oncology residents, the book is organized in concise sections and is amply illustrated to highlight key points and help the reader understand and retain major concepts. Treatment approaches consistent with published clinical trial protocols that define control/standard of care/consensus radiation treatment are included. In addition to serving as a primary introduction to the field, the book also offers a short review of fundamental concepts for the senior resident prior to written or oral examinations, and is a useful resource for the radiation oncology educator to develop teaching plans and quizzes. Chapter organization is based on the International Atomic Energy Agency Syllabus for the Education and Training of Radiation Oncologists, the syllabus endorsed by both the American Society for Radiation Oncology and the European Society for Therapeutic Radiology and Oncology.
Features of Radiation Oncology Primer and Review:
Integrates basic science, clinical science and technical concepts to provide the trainee with a complete introduction to the field of radiation oncologyIs consistent with accepted training syllabus for radiation oncology professionalsOffers a concise presentation with illustrations highlighting key poiintsProvides key points for study and reviewsIncludes treatment approaches consistent with published clinical trial protocols that define control/standard of care/consensus radiation treatmentIs a valuable review resource for board review
Oncology Board Review: Blueprint Study Guide and Q&A is a concise, outline-based study guide covering the topics that appear on the Medical Oncology Certification Exam. This second edition has been thoroughly revised to include new treatment regimens, clinical guidelines, and other updates impacting the field and reflected on the test.
The book includes all topics listed in the American Board of Internal Medicine (ABIM) blueprint as essential material for the Medical Oncology Certification Exam. The coverage spans all hematologic malignancies and solid tumors, beginning with the epidemiology, and followed by the etiology and risk factors of the disease, staging, signs and symptoms, diagnostic criteria, indications for treatment, prognostic factors, treatment recommendations, and special considerations. Later chapters review other major subspecialty areas found on the exam including cancer genetics and tumor biology, supportive and palliative care, bone marrow transplantation, and biostatistics. Each chapter includes key points summarized in digestible bullets for easy recall and self-assessment. And, now containing over 230 board style questions with answers and detailed rationales, Oncology Board Review, Second Edition is the go-to, quick review for any trainee preparing for initial certification and for oncologists preparing for recertification.New to this Edition:Includes over 230 board style questions and answers with rationalesNew chapter on Bone Marrow TransplantationThoroughly updated and revised chapters with all new treatment recommendations and FDA approvals for solid tumors and hematologic malignancies included.
As the pharmacology section continues to represent a major portion of the medical oncology exam and a key component on oncology MOC exams, this portable study guide will help prepare anyone looking to fine-tune their knowledge on cancer drugs before the test. Not to mention, with recent advancements in the field of cancer treatment, it has become more cumbersome to recall and maintain essential knowledge of every cancer therapeutic—making this book not only an exam resource but also a handy quick reference for oncologists and pharmacists alike.
KEY FEATURESConveniently organized and arranged by drug class and subtypes for easier recall and classification Includes proper dosage adjustments to account for liver and kidney dysfunction Features tables throughout that provide quick reference regarding FDA-approved medications Simplified diagrams and illustrations facilitate the pharmacokinetic processes
An empathetic resource full of relatable patient stories, this book teaches patients and caregivers how to ask the right questions to get the best possible care--beginning at the moment of diagnosis. Drs. Jackson and Ryan explain how to work with a team of doctors and nurse practitioners to minimize symptoms and side effects while living as fully as possible in the face of cancer. They relay important information about understanding prognosis, and they translate what doctors mean when they describe tests, treatments, and medical procedures. Finally, they discuss hospice care and answer questions about continuing treatment and managing the final phase of life.
Based on new research and a groundbreaking program in which patients are treated with palliative care--along with the best cancer care--during the course of their illness, this honest and caring book provides the right advice to use at the right time throughout a journey with cancer. It allows a person with cancer to concentrate on living the best life possible, despite an uncertain future. Patients at every stage will find Living with Cancer a comprehensive, thoughtful, and accessible guide for navigating the illness and its treatment.
With its high processing power, cost-effectiveness, and easy deployment, access, and maintenance, the graphics processing unit (GPU) has increasingly been used to tackle problems in the medical physics field, ranging from computed tomography reconstruction to Monte Carlo radiation transport simulation. Graphics Processing Unit-Based High Performance Computing in Radiation Therapy collects state-of-the-art research on GPU computing and its applications to medical physics problems in radiation therapy.
Tackle Problems in Medical Imaging and Radiotherapy
The book first offers an introduction to the GPU technology and its current applications in radiotherapy. Most of the remaining chapters discuss a specific application of a GPU in a key radiotherapy problem. These chapters summarize advances and present technical details and insightful discussions on the use of GPU in addressing the problems. The book also examines two real systems developed with GPU as a core component to accomplish important clinical tasks in modern radiotherapy.
Translate Research Developments to Clinical Practice
Written by a team of international experts in radiation oncology, biomedical imaging, computing, and physics, this book gets clinical and research physicists, graduate students, and other scientists up to date on the latest in GPU computing for radiotherapy. It encourages you to bring this novel technology to routine clinical radiotherapy practice.
In the field of radiobiology, the linear-quadratic (LQ) equation has become the standard for defining radiation-induced cell killing. Radiotherapy Treatment Planning: Linear-Quadratic Radiobiology describes tumor cell inactivation from a radiation physics perspective and offers appropriate LQ parameters for modeling tumor and normal tissue responses.
Explore the Latest Cell Killing Numbers for Defining Iso-Effective Cancer Treatments
The book compiles radiation mechanism information from biophysical publications of the past 50 years, addressing how ionizing radiation produces the killing of stem cells in human tumors. It presents several physical and chemical parameters that can modulate the radiation response of clonogenic cells in tumors. The authors describe the use of the LQ model in basic radiation mechanism studies with cells of relatively homogeneous radiation response and then extend the model to the fitting of survival data generated with heterogeneous cell populations (tumors). They briefly discuss how to use the LQ model for predicting tumor (local) control probability (TCP) and normal tissue complication probability (NTCP). The book also examines potential molecular targets related to alpha- and beta-inactivation and gives suggestions for further molecular characterizations of these two independent processes.
Develop Efficacious, Patient-Friendly Treatments at Reduced Costs
Focusing on quantitative radiobiology in LQ formulation, this book assists medical physicists and radiation oncologists in identifying improved cancer treatments. It also encourages investigators to translate potentially improved radiotherapy schedules based on TCP and NTCP modeling into actual patient benefit.
Since the first edition was published in 2006, Phillip M. Devlinís Brachytherapy has been acknowledged as the essential book on the practice. Inthis updated new edition, all chapters covering cancer sites have been significantly revised. Organized for specialists in several fields, Brachytherapy contains site-specific chapters that discuss how the evolving role of advanced image guidance has demonstrated greater efficacy and less toxicity. Clinical vignettes with images now accompany all site-specific chapters. The chapter on prostate brachytherapy has been expanded to include other indications in the genitourinary system, and there are two entirely new chaptersóone chronicling the history of brachytherapy and the other detailing the emergence of skin brachytherapy.
Dr. Devlin, a leading world authority on brachytherapy, has assembled other leaders in the field from world-renowned radiation oncology programs to enrichthis comprehensive text. From new data on medical outcomes to the costs and benefits of running a brachytherapy practice, Brachytherapy, Second Edition is the first and last word on what still is considered the most conformal radiotherapy technique in the field.
In the new edition:
Over 300 images accompany the chapter text and clinical vignettes
Essential tables and spreadsheets enhance the chapter on running a brachytherapy practice
Ten years of technological advancements are assimilated and reviewed in each site-specific chapter
Includes access to the fully-searchable downloadable ebook
From the Foreword:
ìAs education is essential to advance awareness of and proficiency in the full spectrum of brachytherapy applications, the appearance of the second edition of this highly regarded text is both a timely and most welcome event. The distinguished list of contributors to this work reads like a veritable ìWhoís Whoî of international brachytherapy expertise making this an indispensable resource for students and practitioners of this complex and challenging modality[Ö]A particularly welcome feature is the clinical vignettes at the close of every chapter that bring seemingly remote concepts to life in real world practical applications[Ö]With the second edition of Brachytherapy: Applications and Techniques, Dr. Devlin and colleagues give us a text that instills a profound appreciation for the critical value of this essential modality. This book makes it clear that brachytherapy not only works, it is an irreplaceable component of contemporary cancer care.î
--David Wazer, MD, FACRO, FACR, FASTRO, Professor and Chairman, Departments of Radiation Oncology, Alpert Medical School of Brown University, Providence, RI
New information on developments in the molecular pathogenesis of this disease impacts how physicians approach and treat patients with CLL. The various predisposing factors for the disease are addressed along with current and future treatment modalities and recommended standards of care.
Key features include:introduction by Kanti Rai, MD who developed the Rai Classification and Staging system used in CLL diagnosis CLL in relationship to gene expression profiling and molecular abnormalities familial clustering and gene predisposition targeted therapy trials clinical patient management based upon stage and progression of disease