With contributions from leading international experts inevidence-based medicine, this book is an indispensable guide on howto conduct and interpret studies in clinical diagnosis. It willserve as a valuable resource for all investigators who want toembark on diagnostic research and for clinicians, practitioners andstudents who want to learn more about its principles and therelevant methodological options available.
The inclusion of the latest observational and epidemiologicaldata, as well as randomized controlled trial evidence ensures thatthe book properly reflects the current state of evidence availablefor nephrological practice. It will be a useful aid to allclinicians, including those caring for transplant and pediatricpatients, as it covers the major clinical questions encountered bynephrologists.
This reference is an invaluable source of evidence-basedinformation distilled into guidance for clinical practice whichwill be welcomed by practitioners, trainees and associated healthprofessionals.
This new third edition, written by the world’s leadingcardiologists, provides graded evidence-based reviews of the majortrials together with recommendations for optimum management, andnow includes new grading and recommendation methodology.
This is a unique book in the field of cardiology, and thelargest evidence based clinical cardiology text.
Emergency Care and the Public's Health explores the complex role of emergency care in the context of these changes and as an increasingly vital component of health care systems both within and outside the US.
From an expert emergency medicine team, this new title is a reference for emergency care and critical care providers, allied health professionals and hospital administrators. It is also for relevant for public policy and healthcare policy professionals.
A unique feature is the grading of both the evidence (randomized controlled trials, systematic reviews, or lower quality trials) and the treatment recommendations. This structure provides the reader with valuable guidance on implementation.
The third edition has been fully revised, providing the latest reviews of the evidence. It is also enhanced with new topics that have significant evidence for treatment, including;Esinophilic esophagitis Acute dysenteries Prevention and treatment of travellers’ diarrhoea Frequency of adverse drug effects on bowel function Management of hepatitis B Management of Hepatitis C Vascular disorder of the liver Non invasive diagnosis of liver fibrosis Drug induced liver disease
This book is an essential read for all public healthpractitioners, early childhood professionals, health care providersand clinicians working to reduce the prevalence of childhoodobesity in their communities.
Evidence-based Emergency Medicine is the first book ofits kind in emergency medicine to tackle the problems practicingphysicians encounter in the emergency setting using anevidence-based approach. It summarizes the published evidenceavailable for the diagnosis and treatment of common emergencyhealth care problems in adults. Each chapter contextualizes a topicarea using a clinical vignette and generates a series of keyclinically important diagnostic and treatment questions. Bycompleting detailed reviews of diagnostic and treatment research,using evidence from systematic reviews, RCTs, and prospectiveobservational studies, the authors provide conclusions andpractical recommendations.
Focusing primarily on diagnosis in areas where evidence fortreatment is well accepted (e.g. DVTs), and treatment in otherdiseases where diagnosis is not complex (e.g. asthma), this text iswritten by leading emergency physicians at the forefront ofevidence-based medicine. Evidence-based Emergency Medicineis ideal for emergency physicians and trainees, emergencydepartment staff, and family physicians specialising in the acutecare of medical and injured patients.
Edited and written by the world’s leading infectiousdisease specialists, Evidence-Based Infectious Diseasescontains thoroughly revised clinical chapters, reporting on all newmajor trials and is ideal for; trainees and clinical instructors ininfectious diseases and microbiology, internal medicine physiciansand public health physicians.
In a clear and engaging style, How to Read a Paper demystifies evidence-based medicine and explains how to critically appraise published research and also put the findings into practice.
An ideal introduction to evidence-based medicine, How to Read a Paper explains what to look for in different types of papers and how best to evaluate the literature and then implement the findings in an evidence-based, patient-centred way. Helpful checklist summaries of the key points in each chapter provide a useful framework for applying the principles of evidence-based medicine in everyday practice.
This fifth edition has been fully updated with new examples and references to reflect recent developments and current practice. It also includes two new chapters on applying evidence-based medicine with patients and on the common criticisms of evidence-based medicine and responses.
How to Read a Paper is a standard text for medical and nursing schools as well as a friendly guide for everyone wanting to teach or learn the basics of evidence-based medicine.
Contributes an important advance in the practice of painmanagement providing the information on which to build morecoherent and standardised strategies for relief of patientsuffering
Answers questions about which are the most effective methods,AND those which are not effective yet continue to be used
Includes discussion of the positive and the negative evidence,and addresses the grey areas where evidence is ambivalent
Written by the world's leading experts in evidence-based painmanagement this is a seminal text in the field of pain
Improve your family healthcare practice’s efficiencywith cost-effective referral and consultation guidelines.Identify and treat a broader range of disorders, including diabetic foot infections, hypergonadism, and acute liver failure, with 22 new topics in the Diseases & Disorders section.Improve your interpretation of presenting symptoms with 38 new topics and 40 new images in the Differential Diagnosis section, and optimize patient care with more than 250 new figures and tables.Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets, tables, boxes, and algorithms to expedite your search.Expedite insurance reimbursements with current ICD-9 and future ICD-10 insurance billing codes.Access full-color images and more than 90 online-only topics at Expert Consult, as well as EBMs, Suggested Reading, Patient Teaching Guides, and additional algorithms.
asking clinical questions
searching for answers
discriminating good from poor information and research
using the answers to make clinical decisions.
This attractive, colour workbook provides a clear explanation ofEBP skills and concepts. Written by internationally respectedauthors, this expanded and updated edition has been developed fromevidence-based practice workshops run by the Centre forEvidence-Based Medicine at the University of Queensland and Oxford,and contains information and exercises to help health professionalslearn how to use EBP in their clinical practice.
This book begins with a clinical illustration of the distinction between the patient’s experience and the psycho-analyst’s experience. The succeeding chapters cover the influence of verbal expression, emotional experience, state of mind, and consciousness in psycho-analysis and transformation. These topics are followed by discussion on the relationship of the “no-thing and the thing, wherein the personality that is capable of tolerating a no-thing can make use of the no-thing, and so is able to make use of the so-called thoughts. The remaining chapters describe a clinical system that would represent the chief clinical systems that can be seen to exist in the analytic situation. These chapters also examine the gap between reality and the personality, which are aspects of life with which analysts are familiar under the guise of resistance. Resistance operates because it is feared that the reality of the object is imminent.
This book will be of value to psycho-analysts, psychologists, and psychiatrists.
Comprised of 16 chapters, this book begins with a historical background on bacteriology, followed by a discussion on the biology of bacteria. A classification of bacteria is then presented, and infections caused by bacteria are described. Subsequent chapters focus on body defenses against bacterial infections; killing of bacteria through disinfection and sterilization; antibacterial therapy; and collection of bacteriological specimens as part of bacteriological diagnosis. Infections of the respiratory tract, gastrointestinal tract, and the nervous system are also analyzed. The final chapter is devoted to elementary parasitology.
This monograph is intended for nurses interested in learning more about microbiology and bacteriology.
From the author of the bestselling introduction to evidence-based medicine, this brand new title makes sense of the complex and confusing landscape of implementation science, the role of research impact, and how to avoid research waste.
How to Implement Evidence-Based Healthcare clearly and succinctly demystifies the implementation process, and explains how to successfully apply evidence-based healthcare to practice in order to ensure safe and effective practice. Written in an engaging and practical style, it includes frameworks, tools and techniques for successful implementation and behavioural change, as well as in-depth coverage and analysis of key themes and topics with a focus on:
Groups and teams Organisations Patients Technology Policy Networks and systems
How to Implement Evidence-Based Healthcare is essential reading for students, clinicians and researchers focused on evidence-based medicine and healthcare, implementation science, applied healthcare research, and those working in public health, public policy, and management.
This text discusses:
undertaking an initial diagnosis of the context and reaching a consensus on the evidence to be implemented;
how to link the research evidence with clinical and patients’ experience and local information in the form of audit data or patient and staff feedback;
the range of diagnostic, consensus building and stakeholder consultation methods that can be helpful;
a description of facilitator roles and facilitation methods, tools and techniques;
some of theories that underpin the PARIHS framework and how these have been integrated to inform a revised version of PARIHS
Including internationally-sourced case study examples to illustrate how the facilitation role and facilitation skills have been applied in a range of different health care settings, this is the ideal text for those interested in leading or facilitating evidence based implementation projects, from the planning stage through to evaluation.
We then review the history of communal living for recovering addicts and alcoholics and provide concrete examples of the Oxford House model, which is a widespread communal living option for over 10,000 recovering persons in the US. The structure and philosophy of Oxford Houses are presented along with recent outcome studies providing support for their effectiveness.
This book was published as a special issue in the Journal of Groups in Addiction and Recovery.
Organized into 15 chapters, this book begins with an overview of the aspects of the study of malignant disease and the experience needed by the radiotherapist to function fully as a clinical oncologist. This text then describes briefly the experiments and discoveries of Marie Curie and Wilhelm Konrad Roentgen. Other chapters consider the fundamental physical principles underlying the use of ionizing radiations. This book discusses as well the aspects of treatment using external beam therapy, the machines used, the method of planning treatment, as well as special features of the treatment. The final chapter deals with the effects of radiation on tumor, the normal cell, the tissue or organ, and on the whole body.
This book is a valuable resource for radiotherapists, epidemiologists, pathologists, clinical oncologists, nurses, and medical students.
Focuses on automation of immunoassay for the clinical laboratory
Emphasizes principles, method evaluation, and the systems approach
Aids system selection by evaluation of technical, clinical, operational, and economical parameters
Contains complete descriptions by experts on the latest automated immunoassay systems
Based upon the editor's well-received workshops on automated immunoassay
Organized into three sections encompassing four parts, this book begins with an overview of the size, extent, and progress of peripheral nerve lesions. This text then discusses the nature of the simple movement pattern seen in muscle function testing. Other chapters consider the conditions for analytical physiotherapy and determination of the work capacity of the part of the body being tested. This book discusses as well the possible errors and mistakes that might occur during testing and might decrease the validity of the assessment. The final chapter deals with the demand for a better and a more rational method to therapeutic exercise.
This book is a valuable resource for physiotherapists, orthopedic surgeons, physiologists, neurologists, and rheumatologists.
Some of the topics covered in the book are the ethanol-related liver problem; definition of hyperprolactinaemia; explanation of abnormal plasma magnesium presence in the blood; enzyme defect in acute intermittent porphyria; causes of elevated ketones in a patient’s blood and urine; and description of androgen insensitivity syndrome. The classification and clinical diagnoses of hypercalcaemia are fully covered. The definition and symptoms of Conn’s syndrome are discussed in detail. The text describes in depth the causes of euthyroid hyperthyroxinaemia. The causes of hypermagnesaemia are completely presented. A chapter is devoted to the origins of respiratory alkalosis and hyponatraemia.
The book can provide useful information to doctors, students, and researchers.
This second edition of the book is organized into nine chapters. Several chapters from the first edition were extensive revised. These include Chapter 2 which deals with the tendency to consider all adverse reactions to foods as allergic reactions; Chapter 4 which present additions to the classification of food allergens listed in the first edition; Chapter 5 which focuses on the management of food allergy; and Chapter 9 which examines food allergy in infants.
This book will be interest to medical professionals and others interested in understanding food allergy.
Organized into six chapters, this book begins with an overview of the emotional impact made through scopophilic–exhibitionistic modalities. This text then explains that the social, fighting, and mating rituals of many species involve looking and showing. Other chapters consider the typical connection between the screen function of a memory or remembered fantasy and the screen function of compulsive scopophilic–exhibitionistic reenactment in reducing current anxiety. This book discusses as well the partial instincts of scopophilia and exhibitionism that are present in everyone. The final chapter deals with the concept of psychic masochism that predominates in scopophilic–exhibitionistic suffering.
This book is a valuable resource for psychiatrists, psychoanalysts, and behavioral scientists.
The opening chapter traces the short developmental history and describes the current professional environment of the cognitive-behavioral movement. The chapters that follow represent major contributions by the leading investigators across a number of areas of intervention. Each chapter describes a summary of research in the respective area, a description of the actual intervention procedures with supporting empirical data, and a consideration of the theoretical foundations and potential implications associated with the intervention. The chapter contents vary across three dimensions. First, the interventions range from those that focus on the acquisition of new capacities to those that deal with the control and modification of existing processes. Second, several chapters focus on adult populations, several on child populations, and some on both. Finally, whereas a number of the chapters deal with problems that have been areas of traditional clinical concern, several others explore new and interesting applications for cognitive-behavioral interventions.
The first text of its kind, Translation of Evidence into Nursing and Health Care Practice helps graduate students in Doctor of Nursing Practice (DNP) courses meet the core competency requirements, content, and knowledge of the DNP curriculum. This revolutionary guide focuses particularly on the challenges of translating evidence into practice, one of the DNP course competencies.
Written by nursing faculty who are currently involved in clinical practice and who translate evidence as part of their practice activities, this textbook presents an interdisciplinary application that provides readers with content for both clinical-based and non-clinical based DNP courses. Divided into three main sections, it discusses theoretical and practical challenges to translation of evidence into practice; methods and translation techniques to employ this translation across settings; and related evaluation strategies to demonstrate improvement in practice and clinical care outcomes.Key Topics:
Integration and application of knowledge into practice Leading and evaluating change Leadership strategies for translation Interdisciplinary application across settings Outcomes management for improvement of direct and indirect care Other important features include case studies, suggested activities for application of the content for learning, and an extensive list of references, current web links, and other applicable resources for enhancing graduate student learning.
The book first offers information on the nature of parasitism, characteristics of parasites, relationship of parasites to hosts, physiology and ecology of parasites, infection, transmission and dissemination of parasites, and resistance and immunity to parasitic infections. The text then examines protozoology and helminthology. Discussions focus on the nature and classification of parasitic worms, biology of parasitic worms, pathogenic effects of parasitic worms, and nature and classification of Protozoa.
The manuscript ponders on entomology, malacology, and diagnosis, treatment, and prevention. Topics include classification of mollusks, bionomics and control, nature and classification of Arthropoda of medical and veterinary importance, mosquitoes, bugs, fleas, and mites and ticks.
The publication is a vital reference for researchers interested in parasitology.
The text first covers the multiple contexts of chronic pain, and then proceeds to tackling the biomedical context. Next, the selection talks about the subjective pain experience, along with the measures of psychological status. Chapter 5 discusses the biophysical measurement, while Chapter 6 covers the behavioral observation methods. The text also details clinical pain interview and the selection and integration of pain measures.
The book will be of great use to students of therapeutics related degrees. The text will also serve health professionals as a reference.
Accompanying the book is the Exploratory Software for Confidence Intervals (ESCI) package, free software that runs under Excel and is accessible at www.thenewstatistics.com. The book’s exercises use ESCI's simulations, which are highly visual and interactive, to engage users and encourage exploration. Working with the simulations strengthens understanding of key statistical ideas. There are also many examples, and detailed guidance to show readers how to analyze their own data using the new statistics, and practical strategies for interpreting the results. A particular strength of the book is its explanation of meta-analysis, using simple diagrams and examples. Understanding meta-analysis is increasingly important, even at undergraduate levels, because medicine, psychology and many other disciplines now use meta-analysis to assemble the evidence needed for evidence-based practice.
The book’s pedagogical program, built on cognitive science principles, reinforces learning:
Boxes provide "evidence-based" advice on the most effective statistical techniques. Numerous examples reinforce learning, and show that many disciplines are using the new statistics. Graphs are tied in with ESCI to make important concepts vividly clear and memorable. Opening overviews and end of chapter take-home messages summarize key points. Exercises encourage exploration, deep understanding, and practical applications.
This highly accessible book is intended as the core text for any course that emphasizes the new statistics, or as a supplementary text for graduate and/or advanced undergraduate courses in statistics and research methods in departments of psychology, education, human development , nursing, and natural, social, and life sciences. Researchers and practitioners interested in understanding the new statistics, and future published research, will also appreciate this book. A basic familiarity with introductory statistics is assumed.
Get expert advice from Dr. Steven McGee, an internationally respected authority in physical examination and assessment, pain management, and education in general internal medicine.
See exactly which studies document the significance of various findings thanks to thousands of up-to-date references.Apply the latest knowledge on hot topics such as the value of physical examination in taking care of the ICU patient, accurately diagnosing the etiology of systolic murmurs, diagnosing osteoarthritis and acute vertigo in the dizzy patient, diagnosing hemorrhagic stroke, and diagnosing pleural effusions.
Implement the most current evidence-based approaches for evaluating stance and gait, Schamroth’s sign (for clubbing), dementia, prediction of falls, hepatopulmonary syndrome, atrial fibrillation, relative bradycardia, tourniquet test (for dengue infections), acute stroke, and pleural effusion.
Assess the pretest probability of disease, given particular signs or symptoms, with new at-a-glance tables.
Make effective decisions thanks to updated content throughout, including new EBM boxes covering over 250 recent studies on physical diagnosis—ensuring that all diagnostic information (i.e., sensitivity, specificity, and likelihood ratios) is up to date.
Diagnoses are often just educated guesses, and prognoses less certain still. There is a significant amount of uncertainty in the daily practice of medicine, resulting in confusion and potentially deadly complications. Dr. Steven Hatch argues that instead of ignoring this uncertainty, we should embrace it. By digging deeply into a number of rancorous controversies, from breast cancer screening to blood pressure management, Hatch shows us how medicine can fail-sometimes spectacularly-when patients and doctors alike place too much faith in modern medical technology. The key to good health might lie in the ability to recognize the hype created by so many medical reports, sense when to push a physician for more testing, or resist a physician's enthusiasm when unnecessary tests or treatments are being offered.
Both humbling and empowering, Snowball in a Blizzard lays bare the inescapable murkiness that permeates the theory and practice of modern medicine. Essential reading for physicians and patients alike, this book shows how, by recognizing rather than denying that uncertainty, we can all make better health decisions.
Some of the topics covered in the book are the concept of heterostasis; stressors and conditioning agents; morphology of frostbite; characteristics manifestations of stress; catecholamines and their derivatives; various hormones and hormone-like substances; FFA, triglycerides and lipoproteins; morphologic changes; and hypothalamo-hypophyseal system . The gastrointestinal diseases of adaptation are covered. The schizophrenia and related psychoses is discussed. The text describes the manic-depressive disease and senile psychosis. A study of the experimental cardiovascular diseases and neuropsychiatric diseases is presented. A chapter is devoted to the diseases of adaptation in animals. Another section focuses on the shift in adenohypophyseal activity and catatoxic hormones.
The book can provide useful information to scientists, doctors, students, and researchers.
The book begins with an overview of the humoral immune system and of antibody structure, function, and biosynthesis, which sets the stage for the subsequent discussions of developments in antibody technology. The remaining chapters discuss the making of monoclonal antibodies; the design of antibodies for human therapy; the connection of antibodies (either chemically or genetically) to other potentially therapeutic effector molecules such as toxins, enzymes, or even an antibody of another specificity; idiotypes and anti-idiotypic antibodies; and the ability of antibodies to functionally mimic enzymes and mediate catalysis.
It is hoped that, in addition to illustrating the progress of research in antibody design, the various creative and innovative approaches reviewed in this book will be modified or will stimulate new ideas that will spur the research and application of designer antibodies.
This book discusses immunoglobulins, monoclonal immunoglobulins, IgE and atopic disease, and immune complexes. The antibody deficiency, defects of cell-mediated immunity, disorders of neutrophil function, and overview of autoimmune disease are also covered.
This publication is recommended for junior doctors in training, but is also valuable to senior clinical investigators in all disciplines who find themselves reluctantly obliged to acquire the rudiments of immunology in order to interpret important developments in their own fields.
Some of the topics covered in the book are the pyramidal and extrapyramidal pathways, principles of motor control; effects of lesions in the motor system; muscle spindles and motor control; signals from skin mechanoreceptors in the human hand; afferent c fiber signals and pain; and sympathetic activity in human peripheral nerves. The definition and description of baroreflex control of vasoconstrictor outflow to skeletal muscles are fully covered. An in-depth account of the activity of a motoneuron pool and the muscle activity spectrum is provided. The mechanism of long-latency stretch reflexes and critical exploration of the pyramidal syndrome are completely presented. A chapter is devoted to description of monosynaptic excitability curves after activation of myotatic arc. Another section focuses on the practical applications of pathophysiological analysis.
The text is further divided into five major sections according to the sequence of the workshop sessions. A separate chapter from the sections has been included at the beginning of the book. The introductory chapter clarifies some points in the subject area of NK cells, particularly its definition. The heterogeneity of NK cells is also discussed in this chapter. Then, the book presents the major topics, including the purification and characterization of NK cells and NK target structures and recognition sites. The mechanisms of postrecognition interactions between NK cells and targets; regulation of NK activity and NK cells; and cultured cells with NK-like activity are also discussed.
This book will serve as a helpful guide to students and professionals (scientists, researchers, and professors) in the fields of immunology, biology, microbiology, biochemistry, among others.
The text first introduces the speech-language neurology, and then proceeds to discussing the organization and neural function of the nervous system. Next, the book relates the nervous anatomic systems to language, speech, and hearing. The text also covers clinical speech syndromes and disorders.
The book will be most useful to speech pathologists and therapists. Neurologists and neurosurgeons will also greatly benefit from the text.
The book enumerates the different endocrine glands of the endocrine system, and then details how each gland functions and the parts they play in the metabolism and normal function of the human body. The book also cited disorders of the endocrine system and their treatments.
Physicians, nurses, pathologists, endocrinologists, and students of medicine will find this book a good reference.